A multi-channel liquid path incubation detection and drainage integrated measurement chamber

Abstract

The present invention discloses a multi-channel liquid circuit incubation detection and drainage integrated measurement chamber. It includes a darkroom lower shell, a darkroom upper shell arranged on the upper side of the darkroom lower shell, a rotating shaft connected to the darkroom lower shell by a bearing, and a heating module arranged on the lower side of the darkroom lower shell, one side of the darkroom lower shell is provided with a through hole, the upper side of the darkroom upper shell is provided with a darkroom flip cover, the upper end of the rotating shaft is provided with a rotor, the lower end of the rotating shaft is provided with a driven wheel, the rotor is provided with a reaction cup placement groove and a detection port, the heating module is provided with a heating groove for accommodating a substrate tube and a reconstitution solution tube, and the upper ends of the substrate tube and the reconstitution solution tube are respectively arranged on the upper side of the reaction cup placement groove. The present invention integrates liquid in the liquid circuit, heating reaction, heating liquid, constant temperature detection, and drainage, and has the advantages of simple structure and easy installation.

Description

Technical Field

[0001] The invention relates to the technical field of homogeneous chemiluminescence detectors, and in particular to a multi-channel liquid path incubation detection and liquid discharge integrated measuring chamber. Background Art

[0002] Homogeneous chemiluminescence detector is a commonly used detection instrument. During the detection, two substances, substrate and reconstitution solution, generally need to be added to the reaction cup. In order to ensure the detection accuracy, the detection darkroom needs to be heated and kept at 37°C. At the same time, before adding the substrate and reconstitution solution, the substrate and reconstitution solution need to be heated by incubation. After heating, the substrate and reconstitution solution are supplied to the detection darkroom through the substrate pump and reconstitution solution pump. After replacing the substrate container and the reconstitution solution container, there will be some air bubbles in the substrate tube and the reconstitution solution tube. In order to discharge the air bubbles, the substrate tube and the reconstitution solution tube need to be cleaned to discharge the air bubbles. The existing homogeneous chemiluminescence detector generally makes the incubation and cleaning into one device, and then makes the detection into one device. In this way, the instrument is not only complex in structure, relatively bulky, and troublesome to install, but also relatively cumbersome to use and prone to problems. The incubated substrate and reconstitution solution will reduce a certain temperature before being transferred to the detection darkroom, which will have a certain impact on the detection results. Summary of the invention

[0003] The purpose of the present invention is to provide a multi-channel liquid path incubation detection and liquid discharge integrated measurement chamber in view of the deficiencies in the prior art.

[0004] To achieve the above-mentioned purpose, the present invention provides a multi-channel liquid circuit incubation, detection and discharge integrated measuring chamber, comprising a darkroom lower shell, a darkroom upper shell arranged on the upper side of the darkroom lower shell, a bearing connected to a rotating shaft in the darkroom lower shell, and a heating module arranged on the lower side of the darkroom lower shell, one side of the darkroom lower shell is provided with a through hole, the upper side of the darkroom upper shell is provided with a darkroom flip cover, the upper end of the rotating shaft is provided with a rotor, the lower end of the rotating shaft is provided with a driven wheel, the rotor is provided with a reaction cup placement groove and a detection port, the heating module is provided with a heating groove for accommodating a substrate tube and a rehydration solution tube, and the upper ends of the substrate tube and the rehydration solution tube are respectively arranged on the upper side of the reaction cup placement groove.

[0005] Furthermore, the heating module includes a heating plate arranged on the lower side of the darkroom lower shell and a temperature sensor arranged on the darkroom lower shell, a preheating disk is arranged at intervals on the lower side of the heating plate, an insulation plate is connected to the lower side of the preheating disk, and the heating groove is arranged on the lower side of the preheating disk.

[0006] Furthermore, the cross-section of the lower shell of the darkroom is square, and a notch is vertically provided at one corner. Two transition grooves are provided in the notch for accommodating the substrate tube and the rehydration solution tube respectively. The lower end of the transition groove is arranged opposite to the outlet of the heating groove, and the upper end thereof is arranged flush with the upper surface of the lower shell of the darkroom, and a pressing block is connected to the outer side of the notch.

[0007] Furthermore, a liquid injection pillar is fixed on the upper side of the lower shell of the darkroom, the liquid injection pillar is L-shaped, and two grooves are provided on the outer side thereof, each groove is n-shaped, one end of which is arranged opposite to the upper end of one of the transition grooves, and the other end is arranged downwardly on the upper side of the reaction cup placement slot, a tube pressing block is fixed on the outer side of the liquid injection pillar, and a accommodating cavity is provided at the corresponding position of the upper shell of the darkroom and the liquid injection pillar.

[0008] Furthermore, the reaction cup placement groove runs through the rotor, a liquid collecting groove is provided on the upper bottom side of the darkroom lower shell, and a discharge port connected to the liquid collecting groove is provided on the darkroom lower shell, and the discharge port is used to be connected to a discharge pump through a discharge pipe.

[0009] Furthermore, the liquid collecting tank is in a ring shape, and its depth is gradually reduced from one side of the discharge port to the other side of the discharge port.

[0010] Furthermore, the liquid collecting tank is arranged directly below the reaction cup placement tank.

[0011] Furthermore, a mounting plate is bolted to one side of the lower shell of the darkroom, an infrared transmitting and receiving module is arranged on the mounting plate, and the infrared transmitting and receiving module is arranged opposite to the detection port.

[0012] Furthermore, the heating groove is arranged in a winding manner.

[0013] Furthermore, the gap between the heating plate and the pre-heating disk is 0.5 mm to 1 mm.

[0014] Beneficial effects: The heating module of the present invention can heat the substrate, the rehydration solution and the detection darkroom at the same time, ensuring that the detection darkroom is in a constant temperature state. At the same time, the substrate and the rehydration solution are heated before entering the darkroom. The substrate tube and the rehydration solution tube coming out of the heating module enter the darkroom through the side wall of the lower shell of the darkroom, which has a good thermal insulation effect. When the substrate tube and the rehydration solution tube are cleaned, they can be directly discharged into the liquid collecting tank of the lower shell of the darkroom, and the waste liquid can be discharged through the discharge pump. The present invention integrates liquid path liquid, heating reaction, heating liquid, constant temperature detection and liquid discharge, and has the advantages of simple structure and easy installation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural schematic diagram of a multi-channel liquid circuit incubation, detection and drainage integrated measurement chamber;

[0016] Figure 2 yes Figure 1 A schematic diagram of the local enlarged structure of the middle A area;

[0017] Figure 3 It is a schematic diagram of the exploded structure of a multi-channel liquid path incubation detection and drainage integrated measurement chamber;

[0018] Figure 4 1 is a schematic diagram of a top view of the structure of a darkroom lower shell according to an embodiment of the present invention;

[0019] Figure 5 is a bottom view structural schematic diagram of a preheating plate according to an embodiment of the present invention;

[0020] Figure 6 It is a schematic diagram of the installation of the induction block according to an embodiment of the present invention. DETAILED DESCRIPTION

[0021] The present invention is further explained below in conjunction with the accompanying drawings and specific embodiments. The embodiments are implemented based on the technical solution of the present invention. It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention.

[0022] like Figures 1 to 6As shown, the embodiment of the present invention provides a darkroom lower shell 1, a darkroom upper shell 2 arranged on the upper side of the darkroom lower shell 1, a rotating shaft 3 connected to the darkroom lower shell 1 by a bearing, and a heating module arranged on the lower side of the darkroom lower shell 1. Among them, two bearings are preferably arranged between the rotating shaft 3 and the darkroom lower shell 1, and the two bearings are respectively a bearing 241 and a bearing 242. The darkroom lower shell 1 is preferably connected to the darkroom upper shell 2 and the heating module by bolts. A through hole 4 is provided on one side of the darkroom lower shell 1, and the through hole 4 is used to communicate with the photomultiplier tube. A darkroom flip cover 5 is provided on the upper side of the darkroom upper shell 2, and a rotor 6 is provided at the upper end of the rotating shaft 3. The rotor 6 is arranged in the cavity inside the darkroom lower shell 1, and the rotor 6 can rotate with the rotating shaft 3. A driven wheel 7 is provided at the lower end of the rotating shaft 3, and the driven wheel 7 is preferably a pulley, which is used to connect with the motor, and the rotating shaft 3 is driven by the motor to rotate. A stopper 25 can be provided on the upper side of the driven wheel 7 to prevent the rotating shaft 3 from moving upward and escaping from the upper side of the lower shell 1 of the darkroom. A reaction cup placement groove 8 and a detection port 9 are provided on the rotor 6. The detection port 9 is used to expose the middle part of the reaction cup placement groove 8. The position of the detection port 9 corresponds to the position of the through hole 4. When the darkroom flip cover 5 is opened, the reaction cup to be detected can be placed in the reaction cup placement groove 8 or the detected reaction cup can be taken out from the reaction cup placement groove 8. A heating groove 30 for accommodating a substrate tube and a reconstitution solution tube is provided in the heating module. The upper ends of the substrate tube and the reconstitution solution tube are respectively arranged on the upper side of the reaction cup placement groove 8. The substrate tube and the reconstitution solution tube enter the heating module from the outside respectively and are arranged along the heating groove 30. The upper side of the heating module can heat the air in the upper shell 1 of the darkroom, so that the temperature in the upper shell 1 of the darkroom can be maintained at the set temperature. The lower side of the heating module can heat the substrate and the reconstitution solution in the substrate tube and the reconstitution solution tube in the heating groove 30 to the set temperature (37°C).

[0023] The heating module of the embodiment of the present invention includes a heating plate 10 arranged on the lower side of the darkroom lower shell 1 and a temperature sensor arranged on the darkroom lower shell 1. A sensor mounting hole 26 is provided on the darkroom lower shell 1. The temperature sensor is arranged in the sensor mounting hole 26. The heater 10 is controlled to work according to the signal fed back by the temperature sensor to control the temperature within the set range. A preheating disk 11 is provided at intervals on the lower side of the heating plate 10. The gap between the heating plate 10 and the preheating disk 11 is preferably 0.5mm to 1mm. In this way, the preheating disk 11 and the detection darkroom are ensured to be at the same constant temperature to avoid being too high due to being close to the heating plate 10. The bottom of the darkroom lower shell 1 and the preheating disk 11 are preferably made of aluminum, which has a good thermal conductivity. A heat insulation board 12 is connected to the lower side of the preheating disk 11. The heat insulation board 12 is preferably an engineering plastic board. Avoidance holes are provided in the middle of the heating plate 10, the preheating disk 11 and the heat insulation board 12, which do not affect the rotation of the shaft 3. The heating groove 30 is preferably arranged on the lower side of the preheating plate 11, and a temperature switch mounting hole 27 is preferably provided on one side of the sensor mounting hole 26, and a temperature switch is provided in the temperature switch mounting hole 27. When the temperature sensor fails, if the temperature reaches the temperature switch action temperature, the temperature switch can provide a switch protection signal to prevent the temperature from being too high. The heating groove 30 is preferably arranged in a winding manner to improve the heating effect.

[0024] The cross-section of the darkroom lower shell 1 of the embodiment of the present invention is square-shaped, and a notch is vertically provided at one corner of the darkroom lower shell 1. Two transition grooves 13 for accommodating the substrate tube and the recovery solution tube are provided in the notch, and the lower end of the transition groove 13 is arranged opposite to the outlet of the heating groove 30, so that the substrate tube and the recovery solution tube directly enter the transition groove 13 after coming out of the heating groove 30, and the upper end of the transition groove 13 is arranged flush with the upper surface of the darkroom lower shell 1, so that the substrate tube and the recovery solution tube directly enter the upper side of the darkroom lower shell 106 through the notch, and a pressing block 14 is connected to the outer side of the notch, and the pressing block 14 is preferably bolted to the darkroom lower shell 1. Under the action of the pressing block 14, on the one hand, the substrate tube and the recovery solution tube can be prevented from escaping from the transition groove 13, and on the other hand, it can have a certain heat preservation effect to prevent the substrate and the recovery solution in the substrate tube and the recovery solution tube from lowering their temperature before entering the upper side of the darkroom lower shell 1.

[0025] A liquid injection pillar 15 is fixed on the upper side of the darkroom lower shell 106. The liquid injection pillar 15 is L-shaped, and two grooves 16 are arranged on the outside. Each groove 16 is arranged in an n-shaped shape. Both ends of the two grooves 16 are arranged downward, and one end of each groove 16 is arranged opposite to the upper end of one of the transition grooves 13. Then, the substrate tube and the reconstitution solution tube can enter the groove 16 from the transition groove 13 respectively. The other end of the groove 16 is arranged downward on the upper side of the reaction cup placement groove 8, and a tube pressing block 19 is fixed on the outside of the liquid injection pillar 15. The tube pressing block 19 is preferably fixed to the liquid injection pillar 15 by bolts, and the tube pressing block 19 can stably limit the substrate tube and the reconstitution solution tube in the groove 16. A accommodating cavity is provided at a position corresponding to the liquid injection pillar 15 on the darkroom upper shell 2, and the size and shape of the accommodating cavity are adapted to the liquid injection pillar 15.

[0026] The cuvette placement slot 8 of the embodiment of the present invention is preferably arranged through the rotor 6, and a liquid collecting slot 20 is provided on the upper side of the bottom of the darkroom lower shell 1, and the liquid collecting slot 20 is preferably arranged directly below the cuvette placement slot 8. A discharge port 21 connected to the liquid collecting slot 20 is provided on the darkroom lower shell 1, and the discharge port 21 is used to connect to a discharge pump through a discharge pipe. When air appears in the substrate tube and the reconstitution solution tube, the substrate pump and the reconstitution solution pump can be controlled to operate, and the substrate and reconstitution solution containing air are directly discharged into the darkroom lower shell 1, and then the waste liquid in the liquid collecting slot 20 is discharged through the discharge pump.

[0027] Since the cavity in the lower shell 1 of the darkroom is cylindrical, the liquid collecting tank 20 of the embodiment of the present invention is preferably arranged in a ring shape. In order to facilitate the discharge of waste liquid in the liquid collecting tank 20, the depth of the liquid collecting tank 20 is a smooth gradient structure, and the depth of the liquid collecting tank 20 is arranged from deep to shallow from one side of the discharge port 21 to the opposite side of the discharge port 21.

[0028] In order to facilitate the detection of whether there is a reaction cup in the reaction cup placement slot 8 under the darkroom flip cover 1, a mounting plate 22 is bolted to the middle of the darkroom lower shell 1 on one side of the darkroom flip cover 5, and an infrared transmitting and receiving module 23 is provided on the mounting plate 22. The infrared transmitting and receiving module 23 is arranged opposite to the detection port 9. When the infrared transmitting and receiving module 23 is working, if a reaction cup is placed in the reaction cup placement slot 8 under the darkroom flip cover 5, the infrared light emitted by the infrared transmitting and receiving module 23 will be irradiated on the reaction cup through the detection port 9 and will be returned, and then received by the infrared transmitting and receiving module 23, thereby sensing that a reaction cup is currently placed.

[0029] One end of the darkroom flap 5 of the embodiment of the present invention is hinged to the darkroom upper shell 2, and the other end of the darkroom flap 5 is provided with a sensing block 17, which is preferably a magnetic block. The sensing block 17 is preferably pressed on the darkroom flap 5 through a pull block 29, and the pull block 29 is bolted to the darkroom flap 5. A proximity switch 18 cooperating with the sensing block 17 is provided on the darkroom lower shell 1. When the darkroom flap 5 is in an open state, the sensing block 17 will not trigger the proximity switch 18 to operate. When the darkroom flap 5 is in a closed state, the proximity switch 18 can be triggered to operate. The proximity switch 18 can feed back the state of the darkroom flap 5 to the control panel to avoid invalid detection when the darkroom flap 5 is in an open state.

[0030] In order to facilitate the positioning of the rotor 6, an optical coupling baffle 28 is also provided at the lower end of the rotating shaft 3. The optical coupling baffle 28 is provided with a groove, and photoelectric corresponding switches are provided on the upper and lower sides of the optical coupling baffle 28. The part of the optical coupling baffle 28 other than the groove is blocked between the photoelectric corresponding switches. When the groove rotates to between the photoelectric corresponding switches, a transient signal is generated, and the current position of the rotor 6 is judged by the signal.

[0031] The above is only a preferred embodiment of the present invention. It should be noted that for ordinary technicians in this technical field, other parts not specifically described belong to the prior art or common knowledge. Several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered as the protection scope of the present invention.

Claims

1. A multi-channel liquid path incubation detection and drainage integrated measurement chamber, characterized in that: The invention comprises a darkroom lower shell (1), a darkroom upper shell (2) arranged on the upper side of the darkroom lower shell (1), a rotating shaft (3) connected to the darkroom lower shell (1) by a bearing, and a heating module arranged on the lower side of the darkroom lower shell (1); a through hole (4) is provided on one side of the darkroom lower shell (1); the through hole (4) is used to communicate with a photomultiplier tube; a darkroom flip cover (5) is provided on the upper side of the darkroom upper shell (2); a rotor (6) is provided at the upper end of the rotating shaft (3); a driven wheel (7) is provided at the lower end of the rotating shaft (3); a reaction cup placement groove (8) and a detection port (9) are provided on the rotor (6); a heating groove (30) for accommodating a substrate tube and a rehydration solution tube is provided in the heating module; the upper ends of the substrate tube and the rehydration solution tube are respectively arranged on the upper side of the reaction cup placement groove (8); the substrate tube and the rehydration solution tube respectively enter the heating module from the outside and are arranged along the heating groove (30); The heating module comprises a heating plate (10) arranged on the lower side of the darkroom lower shell (1) and a temperature sensor arranged on the darkroom lower shell (1); a preheating disk (11) is arranged at intervals on the lower side of the heating plate (10); a heat insulation plate (12) is connected to the lower side of the preheating disk (11); and the heating groove (30) is arranged on the lower side of the preheating disk (11); The cross section of the lower shell of the darkroom (1) is square, and a notch is vertically arranged at one corner. Two transition grooves (13) are arranged in the notch for accommodating a substrate tube and a rehydration solution tube respectively. The lower end of the transition groove (13) is arranged opposite to the outlet of the heating groove (30), and the upper end is arranged flush with the upper surface of the lower shell of the darkroom (1). A pressing block (14) is connected to the outer side of the notch; The reaction cup placement groove (8) is arranged through the rotor (6); a liquid collecting groove (20) is arranged on the upper side of the bottom of the darkroom lower shell (1); a discharge port (21) connected to the liquid collecting groove (20) is arranged on the darkroom lower shell (1); and the discharge port (21) is used to be connected to a discharge pump through a discharge pipe.

2. The multi-channel liquid circuit incubation detection and drainage integrated measurement chamber according to claim 1, characterized in that: A liquid injection pillar (15) is fixed on the upper side of the darkroom lower shell (1), the liquid injection pillar (15) is L-shaped, and two grooves (16) are provided on the outer side thereof, each groove (16) is n-shaped, one end of which is arranged opposite to the upper end of one of the transition grooves (13), and the other end of which is arranged downwardly on the upper side of the reaction cup placement groove (8), a tube pressing block (19) is fixed on the outer side of the liquid injection pillar (15), and a receiving cavity is provided at a position corresponding to the liquid injection pillar (15) on the darkroom upper shell (2).

3. The multi-channel liquid circuit incubation detection and drainage integrated measurement chamber according to claim 1, characterized in that: The liquid collecting tank (20) is in a ring shape, and its depth is arranged to gradually decrease from one side of the discharge port (21) to the opposite side of the discharge port (21).

4. The multi-channel liquid circuit incubation detection and drainage integrated measurement chamber according to claim 1, characterized in that: The liquid collecting tank (20) is arranged directly below the reaction cup placement tank (8).

5. The multi-channel liquid circuit incubation detection and drainage integrated measurement chamber according to claim 1, characterized in that: A mounting plate (22) is bolted to one side of the darkroom lower shell (1), and an infrared transmitting and receiving module (23) is provided on the mounting plate (22). The infrared transmitting and receiving module (23) is arranged opposite to the detection port (9).

6. The multi-channel liquid circuit incubation, detection and drainage integrated measurement chamber according to claim 1, characterized in that: The heating groove (30) is arranged in a winding manner.

7. The multi-channel liquid circuit incubation, detection and drainage integrated measurement chamber according to claim 1, characterized in that: The gap between the heating plate (10) and the pre-heating plate (11) is 0.5 mm to 1 mm.

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