Implantable closed-loop stimulation method and device

Abstract

One or more embodiments of this specification disclose an implantable closed-loop stimulation method and device, the method comprising: determining the target frequency of this diagnosis and treatment, judging whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds a threshold; if the judgment result is yes, randomly generating a stimulation signal, and forming a random stimulation sequence based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; and stimulating the target part based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, a stimulation signal can be randomly generated flexibly according to the contacts and stimulation parameters tolerated by the patient. The stimulation signal is randomly generated, and the location and intensity of the stimulation are within the tolerance range of the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect.

Description

Technical Field

[0001] This document relates to the field of medical device technology, and more particularly to an implantable closed-loop stimulation method and apparatus. Background Art

[0002] At present, implantable medical devices have been widely used in clinical medicine to help patients diagnose and treat their conditions. Among them, the implantable electrical stimulation system mainly includes an implantable electrical pulse generator implanted in the body, a stimulation electrode, and an external controller. The electrical stimulation pulses generated by the implantable electrical pulse generator are transmitted to the stimulation electrode, which then electrically stimulates specific neural targets, thereby diagnosing and treating Parkinson's disease, epilepsy and other diseases.

[0003] However, if any abnormal EEG signal is detected with indiscriminate electrical stimulation intervention, it is very easy to cause damage to the functional area of ​​the patient's lesion due to overstimulation. Therefore, it is urgent to find a new diagnostic and treatment stimulation scheme to improve the above defects. Summary of the invention

[0004] The purpose of one or more embodiments of this specification is to provide an implantable closed-loop stimulation method and device to break abnormal EEG loops through randomly generated stimulation signals, reduce excessive stimulation of abnormal EEG, and ensure that implantable diagnosis and treatment plans are safer and more reliable.

[0005] To solve the above technical problems, one or more embodiments of this specification are implemented as follows:

[0006] In the first aspect, an implantable closed-loop stimulation method is proposed, comprising:

[0007] Determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal;

[0008] Determine whether the frequency of the collected bioelectric signal reaches the target frequency and whether the energy of the bioelectric signal exceeds a threshold;

[0009] If the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period;

[0010] A stimulation intervention is performed on the target site based on the stimulation sequence.

[0011] In a second aspect, an implantable closed-loop stimulation device is proposed, comprising:

[0012] A determination module, used to determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal;

[0013] A judgment module, used to judge whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds a threshold;

[0014] a processing module, configured to randomly generate a stimulation signal if the judgment result is yes, and form a random stimulation sequence based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period;

[0015] A stimulation module is used to perform stimulation intervention on the target site based on the stimulation sequence.

[0016] In a third aspect, an implantable closed-loop stimulation system is proposed, comprising the implantable closed-loop stimulation device.

[0017] It can be seen from the technical solutions provided by one or more embodiments of the above specification that the target frequency of this diagnosis and treatment is determined, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; it is judged whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds a threshold; if the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; stimulation intervention is performed on the target part based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, a stimulation signal can be randomly generated flexibly according to the contacts and stimulation parameters tolerated by the patient. The stimulation signal is randomly generated, and the stimulation site and intensity are within the tolerance range of the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate one or more embodiments of this specification or the technical solutions in the prior art, the drawings required for use in the description of one or more embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this specification. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0019] Figure 1 It is a schematic diagram of the steps of an implantable closed-loop stimulation method provided in an embodiment of this specification.

[0020] Figure 2 It is a flow chart of the implantable closed-loop stimulation method provided in the embodiments of this specification.

[0021] Figure 3It is a structural schematic diagram of an implantable closed-loop stimulation device provided in an embodiment of this specification.

[0022] Figure 4 It is a schematic diagram of the structure of an electronic device provided by an embodiment of this specification. DETAILED DESCRIPTION

[0023] In order to enable those skilled in the art to better understand the technical solutions in this specification, the technical solutions in one or more embodiments of this specification will be clearly and completely described below in conjunction with the drawings in one or more embodiments of this specification. Obviously, the one or more embodiments described are only part of the embodiments of this specification, not all of the embodiments. Based on one or more embodiments in this specification, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of this document.

[0024] Embodiment 1

[0025] Reference Figure 1 FIG. 1 is a schematic diagram of the steps of an implantable closed-loop stimulation method provided in an embodiment of the present specification. The implantable closed-loop stimulation method is applicable to an implantable closed-loop system comprising at least an implantable device and an external device. The method may include the following steps:

[0026] Step 102: Determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal.

[0027] It should be understood that in the embodiments of this specification, in order to accurately and reasonably trigger stimulation, it is necessary to determine the reference value used in the diagnosis and treatment process before diagnosis and treatment, that is, the target frequency. The target frequency can be determined by the doctor user based on empirical data, or it can be obtained by learning historical data through a specific algorithm, and the embodiments of this specification are not limited to this.

[0028] Step 104: Determine whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds a threshold.

[0029] In fact, when judging whether the abnormality of the collected bioelectric signal reaches the condition that can trigger stimulation, it is necessary not only to pay attention to the frequency of the current bioelectric signal, but also to pay attention to whether the energy of the current bioelectric signal exceeds the standard. In this way, the accuracy of triggering stimulation can be further improved. The setting of the threshold is similar to the setting of the target frequency, and can refer to the above step 102.

[0030] Step 106: If the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period.

[0031] Only when the frequency of the current bioelectric signal reaches the target frequency and the energy exceeds the threshold, can the random stimulation be triggered. Otherwise, it is regarded as a normal signal and no intervention is performed.

[0032] It should be understood that the stimulation signal described in this specification carries contact information and waveform information; therefore, when randomly generating the stimulation signal, step 106 is specifically performed as follows: based on a preset contact set and a preset waveform parameter set, a random number generator is used to randomly generate the stimulation signal.

[0033] The preset contact set is determined in the following manner:

[0034] It is determined whether the contacts included in the stimulation electrodes in the current implantable device are tolerable to the biological body; if so, all the tolerable contacts are grouped into a preset contact set; otherwise, no processing is performed.

[0035] Considering that the implantable device may have one or more stimulation electrodes, and each stimulation electrode may include one or more contacts, each contact corresponds to a different position of the lesion site of the organism (i.e., the patient). When a stimulation signal is applied to all contacts on all stimulation electrodes, some parts may not need to be stimulated, but this indifferent stimulation will affect the functional areas around the lesion, for example, causing side effects or complications. Therefore, it is necessary to select the contacts that the patient tolerates from the contacts of these stimulation electrodes and organize them into a preset contact set. It should be understood that the number and degree of stimulation that the contacts in this preset contact set can withstand are higher than those of intolerant contacts, thereby reducing the harm caused by excessive stimulation.

[0036] The preset waveform parameter set is determined in the following manner:

[0037] Determine whether the stimulation waveform corresponding to the waveform parameters that can be used by the stimulation electrode in the current implantable device is tolerable to the biological body; if it is tolerable, the waveform parameters corresponding to the tolerable stimulation waveform are aggregated into a preset waveform parameter set; otherwise, no processing is performed.

[0038] The waveform parameters may include information such as amplitude, frequency, pulse width, duration, etc. When judging whether the stimulation waveform corresponding to the waveform parameters that can be used by the stimulation electrode in the current implantable device is tolerable to the organism, the following aspects may be referred to:

[0039] the range of stimulation parameters that the implantable device can withstand;

[0040] The range of stimulation parameters routinely used in clinical medicine;

[0041] Empirical data from physician groups;

[0042] Historical stimulus data;

[0043] Factory-set parameter values ​​for implantable devices.

[0044] Generally, the above five aspects are comprehensively considered, and after weighing and comparing, a set of waveform parameters corresponding to the stimulation signal tolerated by the patient is determined. It should be understood that these sets contain different value ranges of different waveform parameters.

[0045] After the preset contact point set and preset waveform parameter set that the patient can tolerate are determined, they can be sent to a random number generator to generate a random stimulation signal. In fact, the contact points and waveform parameters are randomly combined together, and then a random stimulation signal is generated according to the randomly combined parameters.

[0046] When forming a random stimulation sequence based on the target frequency and the preset stimulation ratio, step 106 can be specifically performed as follows: determining the duration of this random stimulation sequence based on the target frequency; forming a random stimulation sequence according to the preset stimulation ratio within the duration. After determining that the frequency of the collected bioelectric signal reaches the target frequency, the target frequency can be used to determine the duration of this random stimulation sequence. That is, the reciprocal of the target frequency is the duration. At the same time, the ratio of the stimulation signal in the entire random stimulation sequence is determined according to the threshold stimulation ratio, and then the determined stimulation signal is combined with a blank stimulation (which can be no stimulation or a signal that does not cause stimulation) to obtain a random stimulation sequence.

[0047] Step 108: Perform stimulation intervention on the target site based on the stimulation sequence.

[0048] Specifically, when a stimulation signal in the random stimulation sequence arrives, stimulation intervention is performed on the target part corresponding to the contact point selected when the stimulation signal is randomly generated.

[0049] Through the above technical solution, the target frequency of this diagnosis and treatment is determined, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; it is determined whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds the threshold; if the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; stimulation intervention is performed on the target site based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, the patient-tolerant contacts and stimulation waveforms can be flexibly used to randomly generate stimulation signals. The stimulation signal is randomly generated, and the stimulation site and signal are tolerated by the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect.

[0050] Taking EEG signals as an example, the embodiments of this specification are described in detail through a specific flowchart.

[0051] Reference Figure 2 The figure is a flow chart of the implantable closed-loop stimulation method provided in the embodiment of this specification.

[0052] First, the target EEG frequency f can be set, and when the collected EEG signal frequency is greater than or equal to the target EEG frequency f, it is further determined whether the EEG signal energy exceeds the threshold, and if so, a random stimulation sequence is generated, otherwise, no processing is performed.

[0053] In fact, before this, the contact set C = {C1_1, ..., Cn_m} can be predetermined, where Cn_m represents the mth contact on the nth electrode. The patient's tolerable contacts are determined, and the tolerable contacts are selected to be included in the contact set C, while the intolerant contacts are rejected.

[0054] Similarly, the stimulation waveform P={P1, ...Pn} is predetermined, where Pn represents the stimulation parameters tolerated by the patient. The stimulation parameters tolerated by the patient are determined, and the tolerated stimulation parameters are selected and included in the parameter group W. The stimulation parameters that are not tolerated are rejected.

[0055] Afterwards, the contacts in the contact group C and the stimulation parameters in the parameter group W are sent to a random number generator to generate a random stimulation signal S. The random stimulation signal S includes not only a stimulation waveform but also corresponding contact information.

[0056] Finally, in combination with the preset stimulation ratio K, the random stimulation signal S is used to generate a random stimulation sequence Seq=f(f,K), and random stimulation intervention is performed on the contact corresponding to the random stimulation signal S.

[0057] The duration of the random stimulation signal and the total number of random stimulation signals in the random stimulation sequence are determined by the target frequency f.

[0058] Embodiment 2

[0059] Reference Figure 3 As shown, an implantable closed-loop stimulation device provided in an embodiment of this specification may include:

[0060] A determination module 302 is used to determine a target frequency for this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal;

[0061] A judgment module 304 is used to judge whether the frequency of the collected bioelectric signal reaches the target frequency and whether the energy of the bioelectric signal exceeds a threshold;

[0062] The processing module 306 is used to randomly generate a stimulation signal if the judgment result is yes, and form a random stimulation sequence based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period;

[0063] The stimulation module 308 is used to perform stimulation intervention on the target part based on the stimulation sequence.

[0064] Optionally, as an embodiment, the stimulation signal carries contact information and waveform information;

[0065] When randomly generating the stimulation signal, the processing module 306 is specifically used to:

[0066] Based on a preset contact point set and a preset waveform parameter set, a random number generator is used to randomly generate a stimulation signal.

[0067] In a specific implementation of the embodiment of this specification, when the processing module 306 forms a random stimulation sequence based on the target frequency and the preset stimulation ratio, it is specifically used to:

[0068] Determining the duration of the random stimulation sequence based on the target frequency;

[0069] During the duration, a random stimulation sequence is formed according to the preset stimulation proportions.

[0070] In another specific implementation of the embodiment of this specification, the preset contact set is determined in the following manner:

[0071] Determine whether the contacts included in the stimulation electrodes in the current implantable device are tolerable to the biological body;

[0072] If it is tolerated, all the tolerated contacts are grouped into a preset contact set;

[0073] Otherwise, no processing is done.

[0074] In another specific implementation of the embodiment of this specification, the preset waveform parameter set is determined by:

[0075] Determine whether the stimulation waveform corresponding to the waveform parameters that can be used by the stimulation electrode in the current implantable device is tolerable to the biological body;

[0076] If it is tolerated, the waveform parameters corresponding to the tolerated stimulation waveform are organized into a preset waveform parameter set;

[0077] Otherwise, no processing is done.

[0078] In another specific implementation of the embodiment of this specification, when the stimulation module performs stimulation intervention on the target part based on the random stimulation sequence, it is specifically used to:

[0079] When a stimulation signal in the random stimulation sequence arrives, stimulation intervention is performed on the target part corresponding to the contact point selected when the stimulation signal is randomly generated.

[0080] Through the above technical solution, the target frequency of this diagnosis and treatment is determined, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; it is determined whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds the threshold; if the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; stimulation intervention is performed on the target site based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, the patient-tolerant contacts and stimulation waveforms can be flexibly used to randomly generate stimulation signals. The stimulation signal is randomly generated, and the stimulation site and signal are tolerated by the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect.

[0081] Embodiment 3

[0082] The embodiment of this specification also provides an implantable closed-loop stimulation system, including the implantable closed-loop stimulation device. In addition, the system may also include an external device, and other existing accessories or modules.

[0083] Through the above technical solution, the target frequency of this diagnosis and treatment is determined, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; it is determined whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds the threshold; if the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; stimulation intervention is performed on the target site based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, the patient-tolerant contacts and stimulation waveforms can be flexibly used to randomly generate stimulation signals. The stimulation signal is randomly generated, and the stimulation site and signal are tolerated by the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect.

[0084] Embodiment 4

[0085] Figure 4 This is a schematic diagram of the structure of an electronic device according to an embodiment of this specification. Figure 4 At the hardware level, the electronic device includes a processor, and optionally also includes an internal bus, a network interface, and a memory. The memory may include a memory, such as a high-speed random access memory (RAM), and may also include a non-volatile memory (non-volatile memory), such as at least one disk storage. Of course, the electronic device may also include hardware required for other services.

[0086] The processor, network interface and memory can be interconnected through an internal bus, which can be an ISA (Industry Standard Architecture) bus, a PCI (Peripheral Component Interconnect) bus or an EISA (Extended Industry Standard Architecture) bus. The bus can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, Figure 4 Only one bidirectional arrow is used in the diagram, but this does not mean that there is only one bus or only one type of bus.

[0087] The memory is used to store the program. Specifically, the program may include a program code, and the program code includes a computer operation instruction. The memory may include a memory and a non-volatile memory, and provides instructions and data to the processor.

[0088] The processor reads the corresponding computer program from the non-volatile memory into the memory and then runs it, forming an implantable closed-loop stimulation device at the logical level. The processor executes the program stored in the memory and is specifically used to perform the following operations:

[0089] Determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal;

[0090] Determine whether the frequency of the collected bioelectric signal reaches the target frequency and whether the energy of the bioelectric signal exceeds a threshold;

[0091] If the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period;

[0092] A stimulation intervention is performed on the target site based on the stimulation sequence.

[0093] The above is as in this manual Figure 1 The method performed by the device disclosed in the illustrated embodiment can be applied to a processor or implemented by a processor. The processor may be an integrated circuit chip with signal processing capabilities. In the implementation process, each step of the above method can be completed by an integrated logic circuit of hardware in the processor or an instruction in the form of software. The above processor can be a general-purpose processor, including a central processing unit (CPU), a network processor (NP), etc.; it can also be a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field-programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. The methods, steps and logic block diagrams disclosed in one or more embodiments of this specification can be implemented or executed. The general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc. The steps of the method disclosed in one or more embodiments of this specification can be directly embodied as a hardware decoding processor for execution, or a combination of hardware and software modules in the decoding processor for execution. The software module can be located in a storage medium mature in the art such as a random access memory, a flash memory, a read-only memory, a programmable read-only memory, or an electrically erasable programmable memory, a register, etc. The storage medium is located in the memory, and the processor reads the information in the memory and completes the steps of the above method in combination with its hardware.

[0094] The electronic device may also perform Figure 1 The method and the corresponding device are implemented in Figure 1 The functions of the illustrated embodiments will not be described in detail in the embodiments of this specification.

[0095] Of course, in addition to software implementation, the electronic device of the embodiments of this specification does not exclude other implementation methods, such as logic devices or a combination of software and hardware, etc., that is to say, the execution subject of the following processing flow is not limited to each logic unit, but can also be hardware or logic devices.

[0096] Through the above technical solution, the target frequency of this diagnosis and treatment is determined, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; it is determined whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds the threshold; if the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; stimulation intervention is performed on the target site based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, the patient-tolerant contacts and stimulation waveforms can be flexibly used to randomly generate stimulation signals. The stimulation signal is randomly generated, and the stimulation site and signal are tolerated by the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect.

[0097] Embodiment 5

[0098] The embodiment of the present specification also provides a computer-readable storage medium, which stores one or more programs, wherein the one or more programs include instructions, which, when executed by a portable electronic device including a plurality of application programs, enable the portable electronic device to execute Figure 1 The method of the embodiment shown is specifically used to perform the following method:

[0099] Determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal;

[0100] Determine whether the frequency of the collected bioelectric signal reaches the target frequency and whether the energy of the bioelectric signal exceeds a threshold;

[0101] If the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period;

[0102] A stimulation intervention is performed on the target site based on the stimulation sequence.

[0103] Through the above technical solution, the target frequency of this diagnosis and treatment is determined, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; it is determined whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds the threshold; if the judgment result is yes, a stimulation signal is randomly generated, and a random stimulation sequence is formed based on the target frequency and the preset stimulation ratio, wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; stimulation intervention is performed on the target site based on the stimulation sequence. In this way, when it is detected that the bioelectric signal reaches the preset random stimulation condition, the patient-tolerant contacts and stimulation waveforms can be flexibly used to randomly generate stimulation signals. The stimulation signal is randomly generated, and the stimulation site and signal are tolerated by the patient, which significantly reduces the adverse effects on the patient due to excessive stimulation and improves the diagnosis and treatment effect.

[0104] In short, the above description is only a preferred embodiment of this specification and is not intended to limit the protection scope of this specification. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this specification shall be included in the protection scope of this specification.

[0105] The systems, devices, modules or units described in one or more of the above embodiments may be implemented by a computer chip or entity, or by a product having a certain function. A typical implementation device is a computer. Specifically, the computer may be, for example, a personal computer, a laptop computer, a cellular phone, a camera phone, a smart phone, a personal digital assistant, a media player, a navigation device, an email device, a game console, a tablet computer, a wearable device, or a combination of any of these devices.

[0106] Computer readable media include permanent and non-permanent, removable and non-removable media that can be implemented by any method or technology to store information. Information can be computer readable instructions, data structures, program modules or other data. Examples of computer storage media include, but are not limited to, phase change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read-only memory (ROM), electrically erasable programmable read-only memory (EEPROM), flash memory or other memory technology, compact disk read-only memory (CD-ROM), digital versatile disk (DVD) or other optical storage, magnetic cassettes, magnetic tape magnetic disk storage or other magnetic storage devices or any other non-transmission media that can be used to store information that can be accessed by a computing device. As defined herein, computer readable media does not include temporary computer readable media (transitory media), such as modulated data signals and carrier waves.

[0107] It should also be noted that the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprises a ..." do not exclude the existence of other identical elements in the process, method, commodity or device including the elements.

[0108] Each embodiment in this specification is described in a progressive manner, and the same or similar parts between the embodiments can be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, for the system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the relevant parts can be referred to the partial description of the method embodiment.

[0109] The above is a description of a specific embodiment of the specification. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recorded in the claims can be performed in an order different from that in the embodiments and still achieve the desired results. In addition, the processes depicted in the drawings do not necessarily require the specific order or continuous order shown to achieve the desired results. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.

Claims

1. An implantable closed-loop stimulation method, characterized in that: include: Determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; Determine whether the frequency of the collected bioelectric signal reaches the target frequency and whether the energy of the bioelectric signal exceeds a threshold; If the judgment result is yes, a stimulation signal is randomly generated, the stimulation signal carries contact information and waveform information, and forms a random stimulation sequence based on the target frequency and the preset stimulation ratio to reduce overstimulation; wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period, and the randomly generated stimulation signal is generated by a random number generator based on a preset contact set and a preset waveform parameter set, and the preset contact set includes all contacts contained in the stimulation electrode in the current implantable device that are tolerated by the biological body; Based on the random stimulation sequence, when a stimulation signal in the random stimulation sequence arrives, stimulation intervention is performed on a target part corresponding to a contact point selected when the stimulation signal is randomly generated.

2. The implantable closed-loop stimulation method according to claim 1, characterized in that: The preset contact set is determined in the following manner: Determine whether the contacts included in the stimulation electrodes in the current implantable device are tolerable to the biological body; If it is tolerated, all the tolerated contacts are grouped into a preset contact set; Otherwise, no processing is done.

3. The implantable closed-loop stimulation method according to claim 1, characterized in that: The preset waveform parameter set is determined in the following manner: Determine whether the stimulation waveform corresponding to the waveform parameters that can be used by the stimulation electrode in the current implantable device is tolerable to the biological body; If it is tolerated, the waveform parameters corresponding to the tolerated stimulation waveform are organized into a preset waveform parameter set; Otherwise, no processing is done.

4. The implantable closed-loop stimulation method according to any one of claims 1 to 3, characterized in that: Based on the target frequency and the preset stimulation ratio, a random stimulation sequence is formed, specifically including: Determining the duration of the random stimulation sequence based on the target frequency; During the duration, a random stimulation sequence is formed according to the preset stimulation proportions.

5. An implantable closed-loop stimulation device, characterized in that: include: A determination module, used to determine the target frequency of this diagnosis and treatment, wherein the target frequency is a bioelectric signal frequency reference that can trigger a stimulation signal; A judgment module, used to judge whether the frequency of the collected bioelectric signal reaches the target frequency, and whether the energy of the bioelectric signal exceeds a threshold; A processing module, for randomly generating a stimulation signal if the judgment result is yes, the stimulation signal carries contact information and waveform information, and forms a random stimulation sequence based on the target frequency and the preset stimulation ratio to reduce overstimulation; wherein the preset stimulation ratio is the ratio of the stimulation period to the non-stimulation period; when randomly generating the stimulation signal, the processing module uses a random number generator based on a preset contact set and a preset waveform parameter set to randomly generate the stimulation signal, wherein the preset contact set includes all contacts contained in the stimulation electrode in the current implantable device that are tolerated by the biological body; The stimulation module is used to perform stimulation intervention on the target part corresponding to the contact point selected when the stimulation signal is randomly generated based on the random stimulation sequence when the stimulation signal in the random stimulation sequence arrives.

6. The implantable closed-loop stimulation device according to claim 5, characterized in that: When the processing module forms a random stimulation sequence based on the target frequency and the preset stimulation ratio, it is specifically used to: Determining the duration of the random stimulation sequence based on the target frequency; During the duration, a random stimulation sequence is formed according to the preset stimulation proportions.

7. An implantable closed-loop stimulation system, characterized in that: Comprising the implantable closed-loop stimulation device as described in claim 5 or 6.

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