Composition with penetration-promoting effect and preparation method thereof

Abstract

The present invention discloses a composition with a penetration-promoting effect and a preparation method thereof, wherein the composition with a penetration-promoting effect comprises a solvent, a phase A moisturizer, a phase B moisturizer, a phase C moisturizer, a pH regulator, a thickener, a solubilizing agent, a skin conditioner, and a plant extract; wherein the skin conditioner is a compound of a bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, a yeast fermentation product extract, and ergothioneine; wherein the plant extract comprises an baobab seed extract, an echinacea extract, and a wood apple extract. A preparation method of a composition with a penetration-promoting effect is to uniformly stir the components of the composition with a penetration-promoting effect to obtain a composition with a penetration-promoting effect. The present application has the effect of significantly improving skin permeability, promoting effective moisturizing ingredients to penetrate into the stratum corneum of the skin, replenishing moisture for the skin from an endogenous source, and lastingly moisturizing.

Description

Technical Field

[0001] The invention relates to the field of daily cosmetics, in particular to a composition with penetration-promoting effect and a preparation method thereof. Background Art

[0002] With the improvement of living standards, people pay more and more attention to daily skin cleaning and maintenance. In daily skin care, it is inevitable to use facial cleansers and other cleaning products to clean the face. When using facial cleansing products, not only the metabolic products and dirt remaining on the skin surface are taken away, but also the sebum naturally secreted by the skin, etc., which leads to the destruction of the sebum layer on the skin surface and the loss of skin moisture. Therefore, after cleaning the face, the face often feels tight and dry. At this time, it is necessary to replenish facial moisture with skin care products.

[0003] However, most skin care products on the market tend to only act on the surface of the skin and have a good immediate moisturizing effect, but the effective moisturizing ingredients contained in them are difficult to penetrate into the stratum corneum of the skin, resulting in the skin becoming dehydrated again after the moisturizing ingredients of the skin care products evaporate on the surface of the skin, and the long-term moisturizing effect cannot be achieved. Therefore, a skin care product with high permeability and long-lasting moisturizing is urgently needed. Summary of the invention

[0004] In order to further improve the moisturizing performance of skin care products, the present application provides a composition with a penetration-promoting effect. In the process of developing a composition with a penetration-promoting effect, it is found that the skin conditioner formed by compounding a bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, a yeast fermentation product extract, and ergothioneine has the effect of significantly improving skin permeability, and can promote the effective moisturizing ingredients in the composition with a penetration-promoting effect to penetrate into the stratum corneum of the skin, replenish moisture for the skin from an endogenous source, greatly reduce the loss rate of the moisturizing ingredients in the composition with a penetration-promoting effect, and further improve the lasting moisturizing effect of the composition with a penetration-promoting effect.

[0005] In the first aspect, the present application provides a composition with penetration-promoting effect using the following technical solution:

[0006] A composition with penetration-promoting effect, comprising the following components in percentage by weight:

[0007] Phase A moisturizer: 0.24% to 32%;

[0008] Phase B moisturizer: 0.21% to 23%;

[0009] Phase C moisturizer: 0.2% to 30%;

[0010] pH regulator: 0.02% to 6%;

[0011] Thickener: 0.01%~3%;

[0012] Solubilizer: 0.01%~3%;

[0013] Skin conditioning agent: 0.121% to 21%;

[0014] Plant extracts: 0.0121% to 9%;

[0015] Water is the balance;

[0016] The skin conditioning agent is a compound of bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine;

[0017] Among them, plant extracts include baobab seed extract, echinacea extract, and wood apple extract.

[0018] In the above technical scheme, the filtrate of the bifid yeast fermentation product mainly contains amino acid organic acid cytoplasm, and is rich in B vitamins, and has the effect of repairing the skin barrier; decarboxylated carnosine hydrochloride can inhibit the glycosylation of structural proteins, scavenge free radicals, and has obvious anti-aging effects; the yeast fermentation product extract has the effect of diluting melanin and enhancing the elasticity and vitality of skin cells; ergothioneine, as a natural antioxidant, has the effects of tightening pores and anti-oxidation.

[0019] Baobab seed extract is rich in protein and mineral nutrients. It can moisturize dry areas, reduce redness and swelling, and eliminate constant itching caused by eczema. It has strong antioxidant and anti-inflammatory effects. Purple coneflower extract can eliminate free radicals, play a certain auxiliary role in the repair of the skin barrier, has antioxidant properties, and has the effect of alleviating aging. Wood apple extract has a strong ability to scavenge free radicals and has excellent antioxidant and sunscreen effects.

[0020] The skin conditioning agent prepared by compounding bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract and ergothioneine has the effect of significantly improving skin permeability, can promote the effective moisturizing ingredients in the composition with a penetration-promoting effect to penetrate into the stratum corneum of the skin, replenish moisture for the skin from the endogenous source, greatly reduces the loss rate of the moisturizing ingredients in the composition with a penetration-promoting effect, and further improves the long-lasting moisturizing effect of the composition with a penetration-promoting effect.

[0021] The plant extract formed by the compound of baobab seed extract, purple coneflower extract and wood apple extract has the ability to significantly promote the combination of skin keratin and water, significantly improves the hydration of the skin's epidermis, and enables the skin's epidermis to quickly replenish moisture. It is supplemented with the effect of bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergot thiourea to enhance the skin's permeability, allowing the skin to quickly replenish moisture from both the epidermis and dermis. It is supplemented with the effective ingredients for repairing the skin barrier in the composition with the effect of promoting penetration, further improving the skin's water-locking effect, and can effectively improve dry and sensitive skin due to damaged skin barrier, achieving the effect of soothing and moisturizing the skin.

[0022] Preferably, the weight percentage of the filtrate of the bifid yeast fermentation product in the composition having the effect of promoting penetration is: 0.1% to 10%;

[0023] The weight percentage of the decarboxylated carnosine hydrochloride in the composition having the effect of promoting penetration is: 0.01% to 5%;

[0024] The weight percentage of the yeast fermentation product extract in the composition having the effect of promoting penetration is: 0.01% to 5%;

[0025] The weight percentage of the ergothioneine in the composition with the effect of promoting penetration is 0.001% to 1%.

[0026] In the above technical scheme, the skin conditioner compounded according to the above ratio can make the bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine better synergistically compounded, maximize the penetration-promoting effect, and further promote the effective moisturizing ingredients in the composition with the penetration-promoting effect to penetrate into the stratum corneum of the skin.

[0027] Preferably, the weight percentage of the baobab seed extract in the composition having the effect of promoting penetration is: 0.01% to 3%;

[0028] The weight percentage of the purple coneflower extract in the composition with the effect of promoting penetration is: 0.001% to 1%;

[0029] The weight percentage of the wood apple extract in the composition with the effect of promoting penetration is 0.01% to 3%.

[0030] In the above technical scheme, compounding baobab seed extract, purple coneflower extract and wood apple extract according to the above proportion can better promote the synergistic effect among the three, further promote the ability of skin keratin to combine with water, and further improve the hydration of the skin epidermis.

[0031] Preferably, the phase A moisturizer includes betaine, panthenol, 1,2-hexanediol, 1,2-pentanediol, sodium polyglutamate, and dipotassium glycyrrhizinate.

[0032] Preferably, the phase B moisturizer includes glycerin, ethylhexylglycerin, and dipropylene glycol.

[0033] In the above technical scheme, the phase A moisturizer and the phase B moisturizer prepared according to the above formula have a more moisturizing effect on the skin, and are supplemented by the hydration of the skin epidermis promoted by the compound of baobab seed extract, purple echinacea extract, and wood apple extract, and the penetration-promoting effect of the compound of bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine, which further improves the skin rejuvenation effect of the composition with the effect of promoting penetration.

[0034] Preferably, the phase C moisturizer is a compound of butylene glycol and bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate.

[0035] Preferably, the preparation method of the C-phase moisturizing agent is: adding butanediol to bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate and mixing them evenly to obtain the C-phase moisturizing agent.

[0036] In the above technical scheme, the C-phase moisturizing agent compounded according to the above scheme has a more transparent appearance. When the C-phase moisturizing agent configured according to this method is used to prepare a composition with a penetration-promoting effect, the composition with a penetration-promoting effect has a more transparent appearance, further improving the aesthetics of the composition with a penetration-promoting effect.

[0037] Preferably, the plant extract also includes passion fruit extract and kangaroo paw extract.

[0038] In the above technical scheme, passion fruit extract is rich in amino acids and has obvious anti-aging effects; kangaroo paw is an endemic plant species unique to southwestern Australia. Kangaroo paw extract is extracted from the flowers, leaves and stems of the above-ground parts of kangaroo paw. It contains multiple anti-aging ingredients, which can increase the production of tenascin-X, stimulate collagen and elastin synthesis, increase the contractility of fibroblasts, enhance skin firmness and have anti-wrinkle effects.

[0039] The synergistic combination of passion fruit extract and kangaroo paw extract can promote the filling effect of the composition with pro-penetration efficacy on the sebum layer on the surface of the skin, and has the effect of significantly reducing the loss of transepidermal water in the skin in a short period of time, further improving the skin's water-locking ability, and promoting the long-term moisturizing effect of the composition with pro-penetration efficacy.

[0040] In a second aspect, the present application provides a method for preparing a composition having a penetration-promoting effect, using the following technical solution:

[0041] A method for preparing a composition having a penetration-promoting effect comprises the following steps:

[0042] Step 1: Mix water and phase A moisturizer to obtain a first mixture; mix phase B moisturizer and thickener to obtain a second mixture;

[0043] Step 2: Mix the first mixture and the second mixture at 75-78° C., cool to 40-45° C., add phase C moisturizer, pH adjuster, solubilizer, skin conditioner, and plant extract, and stir evenly at 40-45° C. to obtain a composition with penetration-promoting effect.

[0044] Preferably, in the step 2, a C-phase moisturizer, a pH adjuster, a solubilizer, a skin conditioner, and a plant extract are added, stirred evenly at 40 to 45° C., and filtered through a 500 to 800 mesh filter to obtain a composition with a penetration-promoting effect.

[0045] By adopting the above technical scheme, the components of the composition with penetration-promoting effect prepared by adding the components in sequence according to the above steps are dispersed more evenly, the system of the composition with penetration-promoting effect is more stable, and it is less likely to produce separation and precipitation.

[0046] In summary, the present application includes at least one of the following beneficial technical effects:

[0047] 1. The skin conditioning agent prepared by compounding bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract and ergothioneine has the effect of significantly improving skin permeability, can promote the effective moisturizing ingredients in the composition with a penetration-promoting effect to penetrate into the stratum corneum of the skin, replenish moisture for the skin from the endogenous source, greatly reduces the loss rate of the moisturizing ingredients in the composition with a penetration-promoting effect, and further improves the long-lasting moisturizing effect of the composition with a penetration-promoting effect.

[0048] 2. The plant extract composed of baobab seed extract, purple echinacea extract and wood apple extract has the ability to significantly promote the combination of skin keratin and water, significantly improves the hydration of the skin's epidermis, and enables the skin's epidermis to quickly replenish moisture. It is supplemented with bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergot thiourea to enhance the skin's permeability, allowing the skin to quickly replenish moisture from both the epidermis and dermis. It is supplemented with the effective ingredients for repairing the skin barrier in the composition with the effect of promoting penetration, further improving the skin's water-locking effect, and can effectively improve dry and sensitive skin due to damaged skin barrier, and achieve the effect of soothing and moisturizing the skin.

[0049] 3. The synergistic combination of passion fruit extract and kangaroo paw extract can promote the filling effect of the composition with a penetration-promoting effect on the sebum layer on the surface of the skin, and has the effect of significantly reducing the loss of transepidermal water in the skin in a short period of time, further improving the skin's water-locking ability, and promoting the long-term moisturizing effect of the composition with a penetration-promoting effect. DETAILED DESCRIPTION

[0050] Examples 1-3

[0051] A composition with penetration-promoting effect comprises a solvent, a phase A moisturizer, a phase B moisturizer, a phase C moisturizer, an antioxidant, a pH regulator, a thickener, a solubilizer, a skin conditioner, a plant extract and a fragrance.

[0052] Wherein, the solvent is water.

[0053] Among them, phase A moisturizer is a compound of betaine, panthenol, 1,2-hexanediol, 1,2-pentanediol, sodium polyglutamate, and dipotassium glycyrrhizinate.

[0054] Among them, phase B moisturizer is a compound of glycerin, ethylhexylglycerin and dipropylene glycol.

[0055] Among them, the C phase moisturizer is a compound of butanediol and bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate.

[0056] Among them, the antioxidant is p-hydroxyacetophenone.

[0057] Among them, the pH adjuster is a compound of citric acid and sodium citrate.

[0058] Among them, the thickener is xanthan gum.

[0059] Among them, the solubilizer is polyglyceryl-6 caprylate.

[0060] The skin conditioning agent is a compound of bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract and ergothioneine.

[0061] Among them, the plant extract is a compound of baobab seed extract, echinacea extract and wood apple extract.

[0062] Among them, fragrances are essences.

[0063] The filtrate of bifid yeast fermentation product was purchased from Angel Yeast Co., Ltd.

[0064] Among them, yeast fermentation product extract was purchased from Shanghai Huiwen Biotechnology Co., Ltd.

[0065] Among them, baobab seed extract was purchased from Ashland (China) Investment Co., Ltd.

[0066] Among them, the purple coneflower extract was purchased from LipoTrue, SL.

[0067] Among them, the wood apple extract was purchased from Guangzhou Luojie Biotechnology Co., Ltd.

[0068] Among them, the flavors were purchased from Dezhixin Flavors and Fragrances (Nantong) Co., Ltd.

[0069] The dosage of each component in Examples 1-3 is shown in Table 1:

[0070] Table 1:

[0071]

[0072]

[0073] The preparation method of Examples 1-3 comprises the following steps:

[0074] Step 1: Stir water and phase A moisturizer at 78° C. and 200 r / min for 5 min to obtain a first mixture;

[0075] Step 2: Stir the phase B moisturizer and thickener at 78°C and 200 r / min for 5 minutes to obtain a second mixture;

[0076] Step 3: Add butanediol to bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate and stir at 200 r / min for 5 minutes to obtain a phase C moisturizer.

[0077] Step 4: Stir the first mixture and the second mixture at 78°C and 200 r / min for 5 minutes, cool to 45°C, add phase C moisturizer, pH adjuster, solubilizer, skin conditioner, and plant extract, stir at 45°C and 200 r / min for 5 minutes, and filter through an 800-mesh filter to obtain a composition with a penetration-promoting effect.

[0078] Example 4

[0079] A composition with a penetration-promoting effect, which is different from Example 2 in that the plant extract is a compound of baobab seed extract, purple coneflower extract, wood apple extract, passion fruit extract, and kangaroo paw extract. The added amount of passion fruit extract is 0.01 kg, the added amount of kangaroo paw extract is 1 kg, and the added amount of water is adjusted to 41.729 kg.

[0080] Among them, passion fruit extract was purchased from ICHIMARU PHARCOS CO., LTD.

[0081] Among them, kangaroo paw extract was purchased from Guangzhou Luojie Biotechnology Co., Ltd.

[0082] Example 5

[0083] A composition with a penetration-promoting effect, which is different from Example 4 in that the added amount of passion fruit extract is 0.5 kg, the added amount of kangaroo paw extract is 0.1 kg, and the added amount of water is adjusted to 42.139 kg.

[0084] Example 6

[0085] A composition with penetration-promoting effect, which is different from Example 4 in that the added amount of passion fruit extract is 1 kg, the added amount of kangaroo paw extract is 0.01 kg, and the added amount of water is adjusted to 42.729 kg.

[0086] Example 7

[0087] A composition with penetration-promoting effect, which is different from Example 5 in that an equal amount of passion fruit extract is replaced by grape seed extract.

[0088] Among them, grape seed extract is commercially available and extracted using ethanol extraction method with an extraction ratio of 10:1.

[0089] Example 8

[0090] A composition with penetration-promoting effect, which is different from Example 5 in that an equal amount of kangaroo paw extract is replaced by witch hazel extract.

[0091] Among them, witch hazel extract is commercially available and is prepared by water extraction with an extraction ratio of 10:1.

[0092] Comparative Example 1

[0093] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of the filtrate of the bifid yeast fermentation product is replaced by sodium hyaluronate.

[0094] Comparative Example 2

[0095] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of decarboxylated carnosine hydrochloride is replaced by sodium hyaluronate.

[0096] Comparative Example 3

[0097] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of yeast fermentation product extract is replaced by sodium hyaluronate.

[0098] Comparative Example 4

[0099] A composition with penetration-promoting effect, which is different from Example 2 in that ergothioneine is replaced by sodium hyaluronate in equal amounts.

[0100] Comparative Example 5

[0101] A composition with penetration-promoting effect, which is different from Example 2 in that equal amounts of bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine are replaced by water.

[0102] Comparative Example 6

[0103] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of an extract of baobab seeds is replaced by an extract of Centella asiatica.

[0104] Among them, Centella asiatica extract is commercially available and is prepared by water extraction with an extraction ratio of 10:1.

[0105] Comparative Example 7

[0106] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of Echinacea purpurea extract is replaced by a Portulaca oleracea extract.

[0107] Among them, the purslane extract is commercially available and is prepared by water extraction with an extraction ratio of 10:1.

[0108] Comparative Example 8

[0109] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of the wood apple extract is replaced by an aloe extract.

[0110] Among them, aloe vera extract is commercially available and is obtained by water extraction with an extraction ratio of 10:1.

[0111] Comparative Example 9

[0112] A composition with penetration-promoting effect, which is different from Example 2 in that an equal amount of an baobab seed extract, an echinacea extract, and an apple extract are replaced by water.

[0113] Test 1

[0114] Moisture test

[0115] Tested using German Courage+Khazaka's skin moisture tester CM825-MDD.

[0116] 170 volunteers were selected. The volunteers were required to be between 40 and 50 years old, without skin diseases, with no significant difference in skin quality, and the cheek moisture content test was between 40 and 45 without using any skin care products. The volunteers were randomly divided into 17 groups, with 10 people in each group.

[0117] The test was conducted in a room with a constant temperature of 25°C and a relative humidity of 50%. In the first step, the volunteers cleaned their faces and dried them naturally. Then, a skin moisture tester was used to test the basic value of skin moisture content in the middle of the left cheek of the volunteers. The average value of each group of experimental results was taken and recorded as the basic value.

[0118] In the second step, the composition with penetration-promoting effect of the above-mentioned embodiments and comparative examples is applied on the face of the volunteer, and the face is massaged for 1 minute to promote absorption. After that, the volunteer sits quietly in the room for 0.25 hours, during which time he cannot drink water or eat; the skin moisture content at this time is tested in the middle of the left cheek of the volunteer with a skin moisture tester, and the skin moisture content increase value at this time is calculated, which is recorded as the hydration value, and the hydration value = the skin moisture content measured at a fixed time point - the basic value, and the average value of each group of test results is taken. In the third step, the volunteer is free to move indoors, eat and drink water, and the skin moisture content is tested in the middle of the left cheek of the volunteer with a skin moisture tester at 2h, 4h, and 6h, and the skin moisture content growth rate (%) at 2h, 4h, and 6h is calculated respectively, and the skin moisture content increase rate (%) = [(skin moisture content measured at a fixed time point - basic value) / basic value] * 100%, respectively recorded as T1, T2, and T3, and the average value of each group of experimental results is taken. The test results are shown in Table 2.

[0119]

[0120] The above test results show that the water replenishment values ​​of Examples 1-8 and Comparative Examples 1-5 are significantly higher than those of Comparative Examples 6-9, which indicates that Examples 1-8 and Comparative Examples 1-5 have good instant water replenishment effects; the fluctuation range of the water content growth rate of Examples 1-8 and Comparative Examples 6-9 is significantly smaller than that of Comparative Examples 1-5, which proves that Examples 1-8 and Comparative Examples 6-9 have better long-lasting moisturizing effects.

[0121] The difference between comparative examples 1-4 and embodiment 2 is that comparative examples 1-4 respectively use sodium hyaluronate to replace bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, thioneine, and the water content growth rate fluctuation range of comparative examples 1-4 is significantly higher than that of embodiment 2, which proves that the lasting moisture retention of comparative examples 1-4 is lower than that of embodiment 2; the difference between comparative example 5 and embodiment 2 is that comparative example 5 does not contain bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, thioneine, and the water content growth rate fluctuation range of comparative example 5 is significantly higher than that of embodiment 2, which proves that the lasting moisture retention of comparative example 5 is significantly lower than that of embodiment 2; thus, only bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and thioneine are composited to form a skin conditioning agent with the effect of significantly improving skin permeability, and can make moisturizing substances penetrate into the dermis of the skin, replenish moisture for the skin from the skin endogenous source, reduce the loss rate of moisture in the skin, and make the composition with a penetration-promoting effect have a better lasting moisture retention effect.

[0122] The difference between Comparative Examples 6-8 and Example 2 is that Comparative Examples 6-8 use other substances to replace the baobab seed extract, purple echinacea extract, and wood apple extract in equal amounts, and the instant skin moisturizing effect of Comparative Examples 6-8 is significantly lower than that of Example 2; the difference between Comparative Example 9 and Example 2 is that Comparative Example 9 does not contain plant extracts, and the instant moisturizing effect of Comparative Example 9 is significantly lower than that of Example 2; it can be concluded that only the plant extract composed of the compound of the baobab seed extract, the purple echinacea extract, and the wood apple extract has the ability to significantly promote the combination of skin keratin and water, can significantly improve the hydration of the skin epidermis, and enable the skin epidermis to quickly replenish moisture.

[0123] The difference between Example 4-6 and Example 2 is that Example 4-6 newly adds passion fruit extract and kangaroo paw extract, and the instant hydrating effect and lasting moisturizing effect of Example 4-6 are better than those of Example 2; the difference between Example 7-8 and Example 5 is that Example 7-8 replaces passion fruit extract and kangaroo paw extract with other substances in equal amounts, and the instant hydrating effect and lasting moisturizing effect of Example 7-8 are lower than those of Example 5; thus, the compounding of passion fruit extract and kangaroo paw extract can promote the filling effect of the composition with penetration-promoting effect on the skin surface sebum layer, and has the effect of significantly reducing the loss of transepidermal water of the skin in a short time, and can further improve the skin's water-locking ability, and promote the long-lasting moisturizing effect of the composition with penetration-promoting effect.

[0124] Test 2

[0125] 170 healthy female volunteers aged 25 to 35 with dry and allergic facial redness were selected and randomly divided into 17 groups, with 10 people in each group.

[0126] The volunteers used the compositions with penetration-promoting effects of the above-mentioned embodiments and comparative examples respectively in the morning and evening every day for four consecutive weeks.

[0127] Test 1: Transepidermal Water Loss

[0128] The test was performed using the VAPOSCAN AS-VT100RS transepidermal water loss meter.

[0129] The TEWL value of the skin on the middle of the left cheek of the volunteers was measured with a transepidermal water loss meter before the first use, after the first use, after two weeks of use, and after four weeks of use. The lower the TEWL value, the better the skin barrier effect. The TEWL value before the first use was recorded as the basic value, and the TEWL value after the first use, after two weeks of use, and after four weeks of use was recorded as the TEWL value after use. The TEWL value reduction rate (%) after the first use, after two weeks of use, and after four weeks of use was calculated. The TEWL value reduction rate (%) = [(basic value-TEWL value after use) / basic value]*100%, and the test results were averaged. The test results are shown in Table 3.

[0130] Test 2: Skin erythema index EI value

[0131] Tested using the German Courage+Khazaka MX18 skin melanin and hemoglobin tester.

[0132] The skin erythema index (EI) value of the middle of the left cheek of the volunteers was measured with a skin melanin and hemoglobin tester before use and four weeks after use. The lower the measured value, the better the product's skin soothing effect. The test results are shown in Table 3.

[0133] Table 3:

[0134]

[0135]

[0136] The above test results show that the fluctuation range of the TEWL value reduction rate (%) of Examples 1-8 is greater than that of Comparative Examples 1-9, which proves that Examples 1-8 have a good effect of repairing the skin barrier. The skin erythema index EI value of Examples 1-8 after four weeks is significantly lower than that of Comparative Examples 1-9, which proves that Examples 1-8 have a good skin soothing effect.

[0137] The difference between Comparative Examples 1-4 and Example 2 is that Comparative Examples 1-4 respectively use sodium hyaluronate to replace the bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine, and the TEWL value reduction rate (%) of Comparative Examples 1-4 after two weeks and four weeks is significantly smaller than that of Example 2, and the skin erythema index EI value after four weeks is significantly smaller than that of Example 2; The difference between Comparative Example 5 and Example 2 is that Comparative Example 5 does not contain bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine, and the TEWL value reduction rate (%) of Comparative Example 5 after two weeks and four weeks is significantly smaller than that of Example 2, and the skin erythema index EI value after four weeks is significantly smaller than that of Example 2; The difference between Comparative Examples 6-8 and Example 2 is that Comparative Examples 6-8 respectively use other substances in equal amounts to replace the baobab seed extract, purple Echinacea extract and wood apple extract, the TEWL value reduction rate (%) of Comparative Examples 6-8 after two weeks and four weeks is significantly smaller than that of Example 2, and the skin erythema index EI value after four weeks is significantly smaller than that of Example 2; the difference between Comparative Example 9 and Example 2 is that Comparative Example 9 does not contain plant extract, and the TEWL value reduction rate (%) of Comparative Example 9 after two weeks and four weeks is significantly smaller than that of Example 2, and the skin erythema index EI value after four weeks is significantly smaller than that of Example 2; thus, it can be obtained that the plant extract compounded by baobab seed extract, purple echinacea extract and wood apple extract improves the hydration of the epidermis of the skin, and is supplemented by the filtrate of bifid yeast fermentation product, decarboxylated carnosine hydrochloride, yeast fermentation product extract and ergot thiourea to enhance the effect of skin permeability, which can effectively improve the dry and sensitive skin due to damaged skin barrier, and achieve the effect of soothing and moisturizing the skin.

[0138] The difference between Example 4-6 and Example 2 is that Example 4-6 newly adds passion fruit extract and kangaroo paw extract, and the TEWL value reduction rate (%) of Example 4-6 after the first use is significantly higher than that of Example 2; the difference between Example 7-8 and Example 5 is that Example 7-8 replaces passion fruit extract and kangaroo paw extract with other substances in equal amounts, respectively, and the TEWL value reduction rate (%) of Example 7-8 after the first use is significantly lower than that of Example 5; it can be concluded that the compounding of passion fruit extract and kangaroo paw extract has a particularity, which can synergistically promote the filling effect of the composition with penetration-promoting effect on the skin surface sebum layer, and has the effect of significantly reducing the loss of transepidermal water of the skin in a short time.

[0139] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A composition having a penetration-promoting effect, characterized in that: The composition includes the following weight percentages: Phase A moisturizer: 0.24%~32%; Phase B moisturizer: 0.21%~23%; Phase C moisturizer: 0.2%~30%; pH adjuster: 0.02%~6%; Thickener: 0.01%~3%; Solubilizer: 0.01%~3%; Skin conditioning agent: 0.121%~21%; Plant extracts: 0.0121%~9%; Water is the balance; The skin conditioning agent is a compound of bifid yeast fermentation product filtrate, decarboxylated carnosine hydrochloride, yeast fermentation product extract, and ergothioneine; Among them, plant extracts include baobab seed extract, echinacea extract, and wood apple extract; The weight percentage of the filtrate of the bifid yeast fermentation product in the composition with the effect of promoting penetration is: 0.1% to 10%; The weight percentage of the decarboxylated carnosine hydrochloride in the composition having the effect of promoting penetration is: 0.01% to 5%; The weight percentage of the yeast fermentation product extract in the composition having the effect of promoting penetration is: 0.01% to 5%; The weight percentage of the ergothioneine in the composition having the effect of promoting penetration is: 0.001% to 1%; The weight percentage of the baobab seed extract in the composition having the effect of promoting penetration is: 0.01% to 3%; The weight percentage of the purple coneflower extract in the composition with the effect of promoting penetration is: 0.001% to 1%; The weight percentage of the wood apple extract in the composition with penetration-promoting effect is 0.01% to 3%.

2. A composition with penetration-promoting effect according to claim 1, characterized in that: The phase A moisturizing agent includes betaine, panthenol, 1,2-hexanediol, 1,2-pentanediol, sodium polyglutamate and dipotassium glycyrrhizinate.

3. A composition with penetration-promoting effect according to claim 1, characterized in that: The phase B moisturizer includes glycerin, ethylhexylglycerin and dipropylene glycol.

4. A composition with penetration-promoting effect according to claim 1, characterized in that: The phase C moisturizing agent is a compound of butanediol and bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate.

5. A composition having a penetration-promoting effect according to claim 4, characterized in that: The preparation method of the C phase moisturizing agent is as follows: butanediol is added into bis-diethoxydiglycol cyclohexane 1,4-dicarboxylate and mixed evenly to obtain the C phase moisturizing agent.

6. A composition with penetration-promoting effect according to claim 1, characterized in that: The plant extracts also include passion fruit extract and kangaroo paw extract.

7. A method for preparing a composition having a penetration-promoting effect as claimed in any one of claims 1 to 6, characterized in that: The steps include: Step 1: Mix water and phase A moisturizer to obtain a first mixture; mix phase B moisturizer and thickener to obtain a second mixture; Step 2: Mix the first mixture and the second mixture at 75-78°C, cool to 40-45°C, add phase C moisturizer, pH adjuster, solubilizer, skin conditioner, and plant extract, and stir evenly at 40-45°C to obtain a composition with penetration-promoting effect.

8. The method for preparing the composition having the effect of promoting penetration according to claim 7, characterized in that: In the step 2, the C-phase moisturizer, pH adjuster, solubilizer, skin conditioner, and plant extract are added, stirred evenly at 40-45° C., and filtered through a 500-800 mesh filter to obtain a composition with a penetration-promoting effect.

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