Antibacterial liquid for diapers, preparation method and application thereof

Abstract

The present invention discloses an antibacterial liquid for diapers and a preparation method and application thereof, and belongs to the technical field of daily necessities. In parts by weight, the raw materials for preparing the antibacterial liquid include 1 to 10 parts of glycerol, 0.01 to 1 part of dipotassium glycyrrhizinate, 0.01 to 0.5 parts of sodium hyaluronate, 1 to 3 parts of polyglycerol-6 stearate, 0.5 to 2 parts of polyglycerol-6 behenate, 0.5 to 2 parts of tocopherol acetate, 0.01 to 0.05 parts of menthol, 0.5 to 1.5 parts of zinc carbonate hydroxide, 0.01 to 0.1 parts of amber powder, 0.01 to 0.1 parts of pearl powder, 0.5 to 2 parts of Artemisia capillaris extract, 0.1 to 1 parts of glycerol glucoside, 0.01 to 0.5 parts of ammonium acryloyldimethyltaurate / VP copolymer, 1 to 10 parts of butanediol, 0.1 to 1 parts of 1,2-hexanediol, and 70 to 90 parts of deionized water. The invention selects various antibacterial ingredients and scientifically formulates them, so that the prepared product has outstanding antibacterial effect, has good therapeutic effect on baby diaper rash and other buttocks skin problems, and has good market application prospects when applied to diapers.

Description

Technical Field

[0001] The present invention relates to the technical field of daily necessities, and in particular to an antibacterial liquid for diapers, a preparation method thereof and an application thereof. Background Art

[0002] The skin of infants and young children has different physiological characteristics from those of adults. Its structure, composition and function are significantly different from those of adults. Most people believe that the skin structure and function of infants and young children are still in the process of continuous improvement for at least one year after birth. The stratum corneum of infants and young children is thinner than that of adults, the keratinocytes are smaller, the hydration capacity of the skin is not perfect, the stratum corneum contains more water and less natural moisturizing factors, etc. These characteristics make infants and young children more prone to various skin problems. Therefore, within one year after birth, it is also the outbreak period of various skin problems, such as eczema, diaper rash, atopic dermatitis, etc. Understanding the particularity of the structure and physiological characteristics of infant skin is an important basis for skin care and treatment of skin diseases.

[0003] Diaper rash is caused by redness of the skin on the baby's buttocks after being irritated and rubbed by urine, feces and unclean diapers. In severe cases, skin erosion and epidermal exfoliation may occur. It is a contact dermatitis that occurs on the diaper-covered areas around the baby's anus and buttocks. The main causes of diaper rash are damp, rough or unclean diapers, ammonia-producing Bacillus in the stool releases ammonia that irritates the skin, and common Proteus, diphtheroid bacteria and other microorganisms in the stool induce it.

[0004] In response to this type of infant buttocks care problem, major manufacturers are also actively looking for innovative products, such as antibacterial diapers, antibacterial wipes and other products have also emerged. However, many diapers and wipes for infants disclosed in the prior art have defects such as insufficient antibacterial effect, high irritation, and unsuitable for infant skin. For example, patent document CN107670090A provides a method for preparing breathable antibacterial diapers, which has relatively complex ingredients and cumbersome preparation steps; patent document CN115558263A uses metal ions, etc., which has good antibacterial effect, but the safety of using it for infants needs further testing.

[0005] Based on this, it is urgent to develop a diaper that has good antibacterial effect, is suitable for use on infant skin, and is safe and non-irritating. Summary of the invention

[0006] In view of the deficiencies in the prior art, one of the purposes of the present invention is to provide an antibacterial liquid for diapers. Various antibacterial components work synergistically to make the prepared product have outstanding antibacterial effect and have a good therapeutic effect on diaper rash in infants and young children.

[0007] The second object of the present invention is to provide a method for preparing the above-mentioned antibacterial liquid, which is simple, efficient and suitable for industrial production and application.

[0008] The third object of the present invention is to provide an application of the antibacterial liquid in the preparation of antibacterial diapers. The diapers have good antibacterial effect, are suitable for infant skin, are safe and non-irritating, and have a good improvement effect on infant buttocks skin problems.

[0009] In order to achieve the above object, the present invention adopts the following technical solution:

[0010] In a first aspect, the present invention provides an antibacterial liquid for diapers, which is prepared from the following components in parts by weight:

[0011]

[0012] In the above technical scheme, zinc carbonate hydroxide has the effects of detoxification, improving eyesight and removing cataracts, absorbing moisture, relieving itching and healing sores, can partially absorb wound secretions, and can also inhibit the growth of local staphylococci. It has good antiseptic, astringent and protective effects on skin inflammation and surface trauma; pearls have the effects of calming the mind and tranquilizing the nerves, clearing away heat and nourishing yin, removing cataracts and improving eyesight, detoxifying and promoting tissue regeneration, and can be used to resolve toxins, resolve malignant sores, and heal internal ulcers; amber is a hydrocarbon formed by the resin of ancient pine plants buried underground for a long time and condensed, and has the effects of calming the nerves, dispersing blood stasis and stopping bleeding, treating carbuncles, sores, and trauma, and stopping bleeding and promoting tissue regeneration.

[0013] Artemisia capillaris extract is extracted from Artemisia capillaris, which is a plant of the genus Artemisia in the Asteraceae family. Its chemical composition is relatively complex, and its main components include coumarins, chromones, flavonoids, and coumaric acids. It has high medical application value and has liver protection, anti-inflammatory, antioxidant, anti-tumor and antibacterial effects. At present, there are many studies on the agricultural activity of Artemisia capillaris extract, which has a good bactericidal effect on various bacterial pests and diseases. Artemisia capillaris extract is used in cosmetic formulas to inhibit the activity of tyrosinase and reduce the production of melanin, thereby achieving the effect of whitening.

[0014] Menthol is produced in the leaves and is the main component of peppermint oil. It is a type of cyclic monoterpenoid and a highly volatile essential oil produced by plants. Its components are mostly hemiterpenoids, monoterpenoids and sesquiterpenoids. Menthol can give fibers better antibacterial activity and shows inhibitory effects on Staphylococcus aureus and Escherichia coli.

[0015] Sodium hyaluronate is not only a good moisturizer, but also has the function of promoting the proliferation and differentiation of epidermal cells and scavenging oxygen free radicals. It can accelerate the regeneration of epidermal cells, promote the repair of damaged skin, and make the skin delicate, smooth and elastic.

[0016] Dipotassium glycyrrhizinate is a skin conditioner, which is mainly composed of glycyrrhizin (glycyrrhizic acid) in the roots and stems of licorice. It can effectively prevent sensitive inflammation when the skin is irritated, has anti-inflammatory and sedative effects on inflammation caused by sunlight, and has good anti-allergic and repair effects.

[0017] Glyceryl glucoside is a glycoside compound formed by connecting glucose and glycerol through glycosidic bonds. It has good biocompatibility and contributes to the stability of macromolecules. In addition, glyceryl glucoside can inhibit the growth of microorganisms, promote the expression of cell active factors, and penetrate into the dermis, with long-lasting moisturizing, repairing, and soothing effects, thereby enhancing skin elasticity and collagen and promoting skin barrier repair. Glyceryl glucoside can also significantly reduce the release of inflammatory factors such as IL-1β and IL-1α, significantly improve the cell healing rate, and has good repair and soothing effects.

[0018] As a preferred embodiment of the technical solution of the present invention, the antibacterial liquid is prepared from the following components in parts by weight:

[0019]

[0020]

[0021] As a preferred embodiment of the technical solution of the present invention, the antibacterial liquid is prepared from the following components in parts by weight:

[0022]

[0023]

[0024] In a second aspect, the present invention provides a method for preparing the above-mentioned antibacterial solution, comprising the following steps:

[0025] S1, after mixing the first part of deionized water, glycerin, sodium hyaluronate and dipotassium glycyrrhizinate, stirring and heating to T1, homogenizing and dispersing evenly to obtain mixture 1, which is set aside;

[0026] S2, crushing amber powder and pearl powder, sieving and mixing with zinc carbonate hydroxide, then grinding and sieving to obtain a mixed powder; then adding the mixed powder to a mixture of polyglycerol-6 stearate, polyglycerol-6 behenate, tocopherol acetate and menthol, stirring and heating to T2, homogenizing and dispersing uniformly to obtain a mixture 2, which is set aside;

[0027] S3, adding mixture 2 to mixture 1, stirring and mixing, homogeneously dispersing, and then sequentially adding a mixture of ammonium acryloyldimethyltaurate / VP copolymer, butanediol, and the second portion of deionized water, glycerol glucoside, and a mixture of Artemisia capillaris extract, stirring and mixing, and then cooling to T3 to obtain mixture 3;

[0028] S4. Add 1,2-hexanediol to the mixture 3, stir evenly, and then cool to room temperature to obtain the antibacterial solution.

[0029] As a preferred embodiment of the technical solution of the present invention, in step S1, T1 is 78-83°C.

[0030] As a preferred embodiment of the technical solution of the present invention, in step S2, the amber powder and pearl powder are sieved to a mesh number of 100 after being crushed; and are sieved to a mesh number of 160 after being mixed with zinc carbonate hydroxide.

[0031] As a preferred embodiment of the technical solution of the present invention, in step S2, T2 is 78-83°C.

[0032] As a preferred embodiment of the technical solution of the present invention, in step S3, T3 is 40-45°C.

[0033] In a third aspect, the present invention further provides an antibacterial diaper prepared using the antibacterial liquid.

[0034] As a preferred embodiment of the technical solution of the present invention, the preparation method of the antibacterial diaper includes: soaking the non-woven fabric in the antibacterial liquid for 30 to 60 seconds, drying it to form a surface coating layer, and then combining the surface coating layer, the absorbent core layer and the waterproof bottom layer and pressing them into the antibacterial diaper.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] (1) The antibacterial liquid of the present invention contains zinc carbonate hydroxide, pearl powder, and amber powder, which have the effects of absorbing moisture, relieving itching, and healing sores, and can partially absorb wound secretions and inhibit the growth of local staphylococci. These components are commonly used in anorectal disease care and eye care, and are relatively safe and widely used. The inventor unexpectedly discovered that the above three components supplemented with the plant antibacterial agent Artemisia capillaris extract to make diapers have a good therapeutic effect on infant diaper rash.

[0037] (2) The antibacterial liquid of the present invention further adds menthol to enhance the antibacterial effect of the product, and is supplemented with sodium hyaluronate and dipotassium glycyrrhizinate to make the prepared product have a better soothing and moisturizing effect, and then stabilizes the macromolecular components through glycerol glucoside and allows the active ingredients to reach the deep layer of the skin wound surface, so as to better exert the efficacy of the product. The various functional ingredients of the present invention are not simply superimposed combinations, but are scientifically and rigorously formulated in terms of type and dosage, and the various ingredients act synergistically and complement each other.

[0038] (3) The antibacterial liquid of the present invention is safe, non-irritating, and non-addictive, and is suitable for use by infants and young children. After being prepared into diapers, it is particularly suitable for use by infants and young children with skin problems such as diaper rash.

[0039] (4) The preparation method of the antibacterial liquid of the present invention is simple to operate, has strong universality, and is suitable for large-scale production.

[0040] In summary, the present invention selects various antibacterial ingredients and scientifically formulates them, so that the product has outstanding antibacterial effect, has good therapeutic effect on baby diaper rash and other buttocks skin problems, and has good market application prospects when applied to diapers. DETAILED DESCRIPTION

[0041] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Example 1

[0043] This embodiment provides an antibacterial liquid for diapers, which is prepared from the following components by mass:

[0044] Table 1 Raw material composition in Example 1

[0045]

[0046]

[0047] In this embodiment, a method for preparing the above-mentioned antibacterial solution is also provided, comprising the following steps:

[0048] S1. Mix the first part of deionized water, glycerin, sodium hyaluronate and dipotassium glycyrrhizinate in phase A, stir and heat to 80° C., and homogenize and disperse evenly to obtain mixture 1, which is set aside;

[0049] S2, crushing the amber powder and pearl powder in phase B, passing through a 100-mesh sieve, and mixing with zinc carbonate hydroxide, then grinding and passing through a 160-mesh sieve to obtain a mixed powder; then adding the mixed powder to a mixture of polyglycerol-6 stearate, polyglycerol-6 behenate, tocopherol acetate, and menthol, stirring and heating to 80° C., homogenizing and dispersing uniformly to obtain a mixture 2, which is set aside;

[0050] S3, adding mixture 2 to mixture 1, stirring and mixing, homogeneously dispersing, and then sequentially adding the mixture of ammonium acryloyldimethyltaurate / VP copolymer and butanediol in phase C and the second part of the deionized water, glycerol glucoside, and Artemisia capillaris extract in phase D, stirring and mixing, and cooling to 40° C. to obtain mixture 3;

[0051] S4. Add 1,2-hexanediol in phase E to mixture 3, stir evenly, and then cool to room temperature to obtain the antibacterial solution.

[0052] Example 2

[0053] This embodiment provides an antibacterial liquid for diapers, which is prepared from the following components by mass:

[0054] Table 2 Raw material composition in Example 2

[0055]

[0056]

[0057] In this embodiment, a method for preparing the above-mentioned antibacterial solution is also provided, comprising the following steps:

[0058] S1. Mix the first part of deionized water, glycerin, sodium hyaluronate and dipotassium glycyrrhizinate in phase A, stir and heat to 80° C., and homogenize and disperse evenly to obtain mixture 1, which is set aside;

[0059] S2, crushing the amber powder and pearl powder in phase B, passing through a 100-mesh sieve, and mixing with zinc carbonate hydroxide, then grinding and passing through a 160-mesh sieve to obtain a mixed powder; then adding the mixed powder to a mixture of polyglycerol-6 stearate, polyglycerol-6 behenate, tocopherol acetate, and menthol, stirring and heating to 80° C., homogenizing and dispersing uniformly to obtain a mixture 2, which is set aside;

[0060] S3, adding mixture 2 to mixture 1, stirring and mixing, homogeneously dispersing, and then sequentially adding the mixture of ammonium acryloyldimethyltaurate / VP copolymer and butanediol in phase C and the second part of the deionized water, glycerol glucoside, and Artemisia capillaris extract in phase D, stirring and mixing, and cooling to 40° C. to obtain mixture 3;

[0061] S4. Add 1,2-hexanediol in phase E to mixture 3, stir evenly, and then cool to room temperature to obtain the antibacterial solution.

[0062] Example 3

[0063] This embodiment provides an antibacterial liquid for diapers, which is prepared from the following components by mass:

[0064] Table 3 Raw material composition in Example 3

[0065]

[0066] In this embodiment, a method for preparing the above-mentioned antibacterial solution is also provided, comprising the following steps:

[0067] S1. Mix the first part of deionized water, glycerin, sodium hyaluronate and dipotassium glycyrrhizinate in phase A, stir and heat to 80° C., and homogenize and disperse evenly to obtain mixture 1, which is set aside;

[0068] S2, crushing the amber powder and pearl powder in phase B, passing through a 100-mesh sieve, and mixing with zinc carbonate hydroxide, then grinding and passing through a 160-mesh sieve to obtain a mixed powder; then adding the mixed powder to a mixture of polyglycerol-6 stearate, polyglycerol-6 behenate, tocopherol acetate, and menthol, stirring and heating to 80° C., homogenizing and dispersing uniformly to obtain a mixture 2, which is set aside;

[0069] S3, adding mixture 2 to mixture 1, stirring and mixing, homogeneously dispersing, and then sequentially adding the mixture of ammonium acryloyldimethyltaurate / VP copolymer and butanediol in phase C and the second part of the deionized water, glycerol glucoside, and Artemisia capillaris extract in phase D, stirring and mixing, and cooling to 40° C. to obtain mixture 3;

[0070] S4. Add 1,2-hexanediol in phase E to mixture 3, stir evenly, and then cool to room temperature to obtain the antibacterial solution.

[0071] Comparative Example 1

[0072] Except that zinc carbonate hydroxide is not added to phase B, the remaining raw materials and steps are the same as those in Example 1 to prepare an antibacterial solution.

[0073] Comparative Example 2

[0074] Except that glycerol glucoside was not added to phase D, the remaining materials and steps were the same as those in Example 1 to prepare an antibacterial solution.

[0075] Comparative Example 3

[0076] Except that the Artemisia capillaris extract in phase D was replaced by Magnolia officinalis bark extract, the remaining raw materials and steps were the same as those in Example 1 to prepare an antibacterial solution.

[0077] Application Examples

[0078] The non-woven fabric was immersed in the antibacterial liquid prepared in Example 1 and Comparative Examples 1 to 3 for 40 seconds to prepare antibacterial non-woven fabrics, the antibacterial non-woven fabrics were dried at 55°C, and the dried antibacterial non-woven fabrics were used to prepare a surface coating layer, and then the surface coating layer, the absorbent core layer and the waterproof bottom layer were combined and pressed into antibacterial diapers.

[0079] Performance evaluation:

[0080] (1) Antibacterial efficacy test of antibacterial solution

[0081] The antibacterial effect of the antibacterial solution prepared in Examples 1 to 3 was tested according to the method described in Appendix C4 of GB 15979-2002 "Sanitary Standards for Disposable Sanitary Products", the test environment temperature was 19 to 21°C, the relative humidity was 45 to 60%, and the test was repeated three times. The antibacterial rate data of the antibacterial solution prepared in Examples 1 to 3 against Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa are listed respectively, as shown in Tables 4 to 7.

[0082] Table 4 Antibacterial effect of the products in the examples on Escherichia coli

[0083] product Colony count of control group (CFU / mL) Inhibition rate after 2 minutes of action (%) Example 1 <![CDATA[2.69*10 4 ]]> >99.84 Example 2 <![CDATA[2.78*10 4 ]]> >99.39 Example 3 <![CDATA[2.85*10 4 ]]> >99.44

[0084] Table 5 Antibacterial effect of the products in the examples on Staphylococcus aureus

[0085] product Colony count of control group (CFU / mL) Inhibition rate after 2 minutes of action (%) Example 1 <![CDATA[3.08*10 4 ]]> >99.38 Example 2 <![CDATA[3.16*10 4 ]]> >99.39 Example 3 <![CDATA[2.99*10 4 ]]> >99.38

[0086] Table 6 Antibacterial effect of the products in the examples on Candida albicans

[0087] product Colony count of control group (CFU / mL) Inhibition rate after 2 minutes of action (%) Example 1 <![CDATA[5.35*10 4 ]]> >96.35 Example 2 <![CDATA[5.31*10 4 ]]> >95.21 Example 3 <![CDATA[5.47*10 4 ]]> >95.55

[0088] Table 7 Antibacterial effect of the products in the examples on Pseudomonas aeruginosa

[0089] product Colony count of control group (CFU / mL) Inhibition rate after 2 minutes of action (%) Example 1 <![CDATA[3.49*10 4 ]]> >99.41 Example 2 <![CDATA[3.36*10 4 ]]> >99.44 Example 3 <![CDATA[3.68*10 4 ]]> >99.56

[0090] Experiments show that the products prepared in Examples 1 to 3 of the present invention have good antibacterial effects on Escherichia coli, Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa, and the antibacterial rate of the products after 2 minutes of action is substantially greater than 99%.

[0091] (2) Sensory evaluation of human trials

[0092] 40 infants aged 0 to 2 years with erythema and eczema on the buttocks were selected and divided into four groups. The diapers prepared in Example 1 and Comparative Examples 1-3 were distributed free of charge. The diapers were tried for 10 consecutive days as required. The erythema and eczema on the buttocks of each group of infants and adverse reactions were observed on the 5th and 10th days of the trial, and questionnaire reports were filled out. The following efficacy judgment criteria were formulated:

[0093] Significantly effective: All erythema and eczema disappeared.

[0094] Effective: Erythema and eczema are significantly improved.

[0095] Ineffective: There is no significant improvement in erythema and eczema, or the condition may even get worse.

[0096] The therapeutic effects are shown in Tables 8 and 9.

[0097] Table 8 Results of clinical trial after 5 days

[0098] Group Total number of cases Number of effective cases Number of effective cases Invalid cases Efficiency Example 1 10 4 6 0 100％ Comparative Example 1 10 1 4 5 50％ Comparative Example 2 10 2 4 4 60％ Comparative Example 3 10 3 4 3 70％

[0099] Table 9 Results of clinical trial after 10 days

[0100] Group Total number of cases Number of effective cases Number of effective cases Invalid cases Efficiency Example 1 10 8 2 0 100％ Comparative Example 1 10 2 5 5 70％ Comparative Example 2 10 4 4 2 80％ Comparative Example 3 10 4 5 1 90％

[0101] Result analysis: All infants had no allergic and uncomfortable adverse reactions during the trial, and the product safety was relatively high. In addition, the trial efficacy observation results showed that the diapers prepared by the present invention were effective quickly, with an effective rate of up to 100% after 5 days of use, which was significantly higher than the diapers prepared by the comparative example. This shows that the diapers prepared by the antibacterial liquid of the present invention have a very significant improvement effect on the erythema and eczema of the baby's buttocks skin, with an effective rate of up to 100%, and no adverse reactions were observed during the treatment process, which is worthy of clinical promotion and application.

[0102] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate the antibacterial liquid for diapers with antibacterial efficacy and the preparation method thereof, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of individual raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. An antibacterial liquid for diapers, characterized in that: In parts by weight, it is prepared from the following ingredients: The method for preparing the antibacterial solution comprises the following steps: S1, after mixing the first part of deionized water, glycerin, sodium hyaluronate and dipotassium glycyrrhizinate, stirring and heating to T1, homogenizing and dispersing evenly to obtain mixture 1, which is set aside; S2, crushing amber powder and pearl powder, sieving and mixing with zinc carbonate hydroxide, then grinding and sieving to obtain a mixed powder; then adding the mixed powder to a mixture of polyglycerol-6 stearate, polyglycerol-6 behenate, tocopherol acetate and menthol, stirring and heating to T2, homogenizing and dispersing uniformly to obtain a mixture 2, which is set aside; S3, adding mixture 2 to mixture 1, stirring and mixing, homogeneously dispersing, and then sequentially adding a mixture of ammonium acryloyldimethyltaurate / VP copolymer, butanediol, and the second portion of deionized water, glycerol glucoside, and a mixture of Artemisia capillaris extract, stirring and mixing, and then cooling to T3 to obtain mixture 3; S4, adding 1,2-hexanediol to the mixture 3, stirring evenly, and then cooling to room temperature to obtain the antibacterial solution; Wherein, in step S1, T1 is 78-83°C; Wherein, in step S2, the amber powder and pearl powder are sieved to a mesh number of 100 after being crushed; and are sieved to a mesh number of 160 after being mixed with zinc carbonate hydroxide; Wherein, in step S2, T2 is 78-83°C; Wherein, in step S3, T3 is 40-45°C.

2. The antibacterial liquid for diapers according to claim 1, characterized in that: In parts by weight, it is prepared from the following ingredients:

3. The antibacterial liquid for diapers according to claim 1, characterized in that: In parts by weight, it is prepared from the following ingredients:

4. An antibacterial diaper, characterized in that: The antibacterial liquid is prepared by using the antibacterial liquid according to any one of claims 1 to 3.

5. A method for preparing the antibacterial diaper according to claim 4, characterized in that: include: The nonwoven fabric is soaked in the antibacterial liquid for 30 to 60 seconds, dried to form a surface coating layer, and then the surface coating layer, the absorbent core layer and the waterproof bottom layer are combined and pressed to form an antibacterial diaper.

Images