Composition, hawthorn dandelion microbubble tablet and preparation method thereof

Hawthorn dandelion micro bubble sheets were prepared through the combination of hawthorn, tangerine peel, fried malt and epizoon, which solved the limitations of the existing technology's inability to completely solve the oral sub-health problems, and achieved effective swelling, pain, bleeding and odor of the gums Relieve and have good taste and industrial adaptability.

CN116548612BActive Publication Date: 2025-01-10JIANGZHONG PHARMA CO LTD
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Patent Information

Application Number
CN202310643300.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-06-01
Publication Date
2025-01-10
Estimated Expiration
2043-06-01

AI Technical Summary

Technical Problem

Existing oral microeffervescent tablets cannot completely solve oral sub-health problems and have application limitations.

Method used

The hawthorn dandelion microbubble sheets formed by combining hawthorn, tangerine peel, fried malt and epibiotics (such as Lactobacillus plantarum L-137, Probio-MT, Lactobacillus curly KT-11) are prepared through reasonable proportioning and tableting process. Compositions with the effects of clearing heat and detoxifying, anti-inflammatory, digesting food and strengthening the stomach are produced, and are used to relieve symptoms such as swelling and painful gums, bleeding and odor of breath.

Benefits of technology

Effectively alleviate oral sub-health problems, enhance oral antibacterial ability and immune response, provide a good taste and experience, and is suitable for industrial production.

✦ Generated by Eureka AI based on patent content.

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Abstract

The present invention relates to the technical field of functional foods, and in particular to a composition, a hawthorn dandelion microbubble tablet and a preparation method thereof. In parts by mass, the active raw materials forming the composition capable of improving oral sub-health include 10-20 parts of hawthorn malt powder, 1-5 parts of dandelion and 3-8 parts of postbiotics; wherein the hawthorn malt powder is composed of hawthorn, tangerine peel and fried malt. The composition can safely and effectively alleviate oral sub-health problems, and has a good taste and a good experience.
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Description

Technical Field

[0001] The invention relates to the technical field of functional foods, and in particular to a composition, a hawthorn and dandelion microbubble tablet and a preparation method thereof. Background Art

[0002] With the accelerated pace of modern life, various factors such as poor oral hygiene habits and living habits have led to a high incidence of oral micro-injuries. According to research, bleeding gums and bad breath are the most common oral problems.

[0003] At present, oral micro-damage repair products are increasingly abundant, including electric toothbrushes, toothpaste, water flossers, oral cleaning tools, mouthwashes, oral fresheners and tooth powders, etc. Among them, the micro-effervescent tablets in oral fresheners are popular among consumers due to their unique dosage form and rich experience. For example, Chinese patent application CN 109303334B discloses an oral micro-effervescent tablet and a preparation method thereof, which includes nutrients, sugar alcohols, acid sources, alkali sources, magnesium stearate, flavors and sweeteners; sugar alcohols are one or a combination of lactose, maltitol, sorbitol, isomalt, mannitol, and erythritol; sweeteners are one or a combination of sucralose, aspartame, stevioside, fructose, white sugar, and mogroside. This invention adds appropriate amounts of acid, alkali, sweeteners and flavors to nutrients, which, under the action of saliva in the mouth, produce micro-effervescence, good taste and strong experience. At the same time, this invented product solves the problem of serious moisture absorption of effervescent tablets during the production process or accelerated testing, and has a certain effect of freshening breath. However, it cannot completely solve the problem of oral sub-health and has certain application limitations.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] The purpose of the present invention is to provide a composition, a hawthorn dandelion microbubble tablet and a preparation method thereof. The composition provided by the embodiment of the present invention can safely and effectively alleviate oral sub-health problems, and has a good taste and a good experience.

[0006] The present invention is achieved in that:

[0007] In a first aspect, the present invention provides a composition capable of improving oral sub-health, wherein the active raw materials forming the composition include, by weight, 10-20 parts of hawthorn malt powder, 1-5 parts of dandelion and 3-8 parts of postbiotics; wherein the hawthorn malt powder consists of hawthorn, tangerine peel and roasted malt.

[0008] In an optional embodiment, the mass ratio of the hawthorn, the tangerine peel and the roasted malt is 1:1.2-1.8:0.15-0.25.

[0009] In an alternative embodiment, the postbiotic comprises at least one of Lactobacillus plantarum L-137, Probio-MT and Lactobacillus crispatus KT-11.

[0010] In a second aspect, the present invention provides a hawthorn and dandelion microbubble tablet, the raw materials of which include the composition capable of improving oral sub-health as described in any one of the aforementioned embodiments.

[0011] In an optional embodiment, every 100 g of the hawthorn dandelion microbubble tablets comprises the following raw materials in mass fractions: 10-20% hawthorn malt powder, 1-5% dandelion, 40-50% diluent, 15-25% acid source disintegrant, 10-20% alkali source disintegrant, 1-4% lubricant, 0.1-1% sweetener, 1-5% flavor and 3-8% postbiotics.

[0012] In an optional embodiment, every 100 g of hawthorn dandelion microbubble tablets includes the following raw materials in percentage by mass: 13.33% hawthorn malt powder, 2.67% dandelion, 41.5% diluent, 18% acid source disintegrant, 15% alkali source disintegrant, 1.67% lubricant, 0.5% sweetener, 3.33% flavor and 4% postbiotics.

[0013] In an optional embodiment, the diluent includes sorbitol; the acid source disintegrant includes anhydrous citric acid; the alkali source disintegrant includes sodium bicarbonate; the lubricant includes magnesium stearate; and the sweetener includes sucralose.

[0014] In a third aspect, the present invention provides a method for preparing the hawthorn and dandelion microbubble tablets described in the aforementioned embodiment, comprising: mixing the raw materials and then pressing them into tablets.

[0015] In an optional embodiment, it includes:

[0016] (1) Raw material pretreatment: The diluent and the acid source disintegrant are crushed and sieved, and then dried until the moisture content is less than 4% to obtain material A;

[0017] Drying the alkaline source disintegrant until the moisture content is less than 4% to obtain material B;

[0018] (2) Mixing: Mixing the material A, the material B, hawthorn malt powder, dandelion powder, flavor, sweetener, lubricant and postbiotics in a machine until the material is visually uniform in color and free of lumps;

[0019] (3) Dry direct compression tableting is adopted.

[0020] In an optional embodiment, the method comprises: (1) the sieve has a pore size of 60-100 mesh;

[0021] (2) The mixing conditions are: mixing speed is 15-25 rpm, and mixing time is 15-25 minutes;

[0022] (3) The hardness of the tablets after medium compression is 150-200N.

[0023] The present invention has the following beneficial effects: the present invention forms a composite by reasonably combining hawthorn malt powder, postbiotics and dandelion. Since traditional Chinese medicine believes that oral sub-health, such as gingival swelling and pain, bleeding, decay and other symptoms, is related to gastrointestinal fire, and belongs to the disease of blazing stomach fire, the reasonable combination of the three can help digestion and anti-inflammatory, and can well alleviate oral sub-health. At the same time, the form of oral micro-effervescent tablets can also well alleviate oral sub-health, and give the product a rich taste and experience. At the same time, the present invention adopts the product form of micro-effervescent tablets, and the prepared hawthorn dandelion micro-bubble tablets have good taste, good industrial and production adaptability, and are suitable for industrialization and large-scale production. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0025] The embodiment of the present invention provides a composition capable of improving oral sub-health. The active raw materials forming the composition include 10-20 parts of hawthorn malt powder, 1-5 parts of dandelion and 3-8 parts of postbiotics, based on weight.

[0026] The composition capable of improving oral sub-health provided by the embodiment of the present invention adopts a reasonable combination of hawthorn, tangerine peel and fried malt, wherein hawthorn can help digestion and invigorate the stomach, and is used for meat stagnation and stomach distension; fried malt can promote qi and digestion, invigorate the spleen and stimulate the appetite, and is used for indigestion and abdominal distension; tangerine peel can regulate qi and invigorate the spleen, and is used for abdominal distension, anorexia and vomiting and diarrhea. The hawthorn malt powder has good effects of invigorating the stomach and digestion; dandelion has bitter, sweet and cold properties, enters the liver and stomach meridians, has the effects of clearing away heat and detoxifying and anti-inflammatory, and has good effects on alleviating oral halitosis and gum health. In addition, postbiotics - oral inactivated probiotics are added in the embodiments of the present invention, which can increase the antibacterial ability of the human oral cavity on the one hand, specifically by increasing the expression of human defensin-2 (HBD-2) in the muscle epithelial cells of the teeth, thereby enhancing the antibacterial ability of the oral cavity; on the other hand, they can enhance the immune response of the human oral cavity, specifically by the antibodies (IgG and specific antibodies IgG) in the plasma being transmitted to the gingival sulcus through the capillaries, thereby promoting the secretion of IgA in saliva, inhibiting the excessive reproduction of bacteria, and enhancing local immunity of the oral cavity.

[0027] Among them, the hawthorn malt powder is composed of hawthorn, tangerine peel and fried malt. Specifically, the hawthorn malt powder is obtained by hot water extraction of hawthorn, tangerine peel and fried malt and spray drying, and the mass ratio of the hawthorn, the tangerine peel and the fried malt is 1:1.2-1.8:0.15-0.25. For example, the mass ratio is 1:1.2:0.25; 1:1.5:0.2; 1:1.8:0.25; 1:1.2:0.15 and 1:1.3:0.18, etc., and the preferred mass ratio is 1:1.5:0.2. The hawthorn malt powder composed of hawthorn, tangerine peel and fried malt provided by the embodiment of the present invention has a good effect of strengthening the stomach and digestion, and reduces the formation of bad breath.

[0028] Further, the postbiotics include at least one of Lactobacillus plantarum L-137, Probio-MT and Lactobacillus crispatus KT-11.

[0029] In a second aspect, the present invention provides a hawthorn and dandelion microbubble tablet, the raw materials of which include the composition capable of improving oral sub-health as described in any one of the aforementioned embodiments.

[0030] Specifically, every 100 g of the hawthorn and dandelion microbubble tablets includes the following raw materials in different mass fractions: 10-20% hawthorn malt powder, 1-5% dandelion, 40-50% diluent, 15-25% acid source disintegrant, 10-20% alkali source disintegrant, 1-4% lubricant, 0.1-1% sweetener, 1-5% flavor and 3-8% postbiotics.

[0031] For example, the amount of hawthorn malt powder is any value between 10-20%, such as 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, and 20%. The amount of dandelion is any value between 1-5%, such as 1%, 2%, 3%, 4%, and 5%. The amount of diluent is any value between 40-50%, such as 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, and 50%. The amount of acid source disintegrant is any value between 15-25%, such as 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, and 25%. The amount of alkaline source disintegrant is any value between 10-20%, such as 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19% and 2%. The amount of lubricant is any value between 1-4%, such as 1%, 2%, 3% and 4%. The amount of sweetener is any value between 0.1-1.0%, such as 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9% and 1.0%. The amount of flavor is any value between 1-5%, such as 1%, 2%, 3%, 4% and 5%. The amount of postbiotics is any value between 3-8%, such as 3%, 4%, 5%, 6%, 7% and 8%.

[0032] Preferably, every 100 g of hawthorn and dandelion microbubble tablets comprises the following raw materials in percentage by mass: 13.33% hawthorn malt powder, 2.67% dandelion, 41.5% diluent, 18% acid source disintegrant, 15% alkali source disintegrant, 1.67% lubricant, 0.5% sweetener, 3.33% flavor and 4% postbiotics.

[0033] The oral microbubble tablet used in the embodiment of the present invention is micro-bubbled by adding appropriate amounts of acid, alkali, sweetener and flavor under the action of saliva in the mouth, with good taste and strong experience. It is no longer a nutrient that is difficult to swallow or gets stuck in the throat or smells bad, but a nutrient that is delicious and fun. It has good adaptability to the population, industry and production, and is suitable for industrialization and large-scale production.

[0034] Furthermore, the diluent includes sorbitol; the acid source disintegrant includes anhydrous citric acid; the alkali source disintegrant includes sodium bicarbonate; the lubricant includes magnesium stearate; and the sweetener includes sucralose. The flavor can be an existing flavor, such as tangerine peel flavor.

[0035] In a third aspect, the present invention provides a method for preparing the hawthorn and dandelion microbubble tablets described in the aforementioned embodiment, comprising: mixing the raw materials and then tableting. The specific process is as follows:

[0036] (1) Raw material pretreatment: The diluent and the acid source disintegrant are crushed and sieved, and then dried until the moisture content is less than 4% to obtain material A; wherein the sieve aperture is 60-100 mesh.

[0037] The alkali source disintegrant is dried until the moisture content is less than 4% to obtain material B.

[0038] (2) Mixing: The material A, the material B, hawthorn malt powder, dandelion powder, flavor, sweetener, lubricant and postbiotics are mixed in a machine until the material is visually uniform in color and free of lumps; wherein the mixing conditions are: a mixing speed of 15-25 rpm and a mixing time of 15-25 minutes; preferably, a mixing speed of 20 rpm and a mixing time of 20 minutes.

[0039] (3) Tableting by dry direct compression. Specifically, a circular mold with a diameter of 12 mm was used to prepare the sample by dry direct compression, and the tablet weight was controlled to be 0.6 g to obtain a microbubble tablet, ensuring that the tablet shape was complete, the surface was smooth, and the tablet weight was stable. The hardness of the tablet after tableting was 150-200N.

[0040] (4) Bottling: The microbubble tablets are sieved to remove fine powder on the surface and packed into customized packaging bottles, 30 tablets / bottle, to obtain the finished product.

[0041] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0042] Example 1

[0043] The embodiment of the present invention provides a hawthorn dandelion microbubble tablet, wherein each 1000g of the hawthorn dandelion microbubble tablet comprises the following raw materials: 100g of hawthorn malt powder, 50g of dandelion powder, 446g of sorbitol, 250g of anhydrous citric acid, 100g of sodium bicarbonate, 10g of magnesium stearate, 4g of sucralose, 10g of tangerine peel essence and 30g of postbiotics. The hawthorn malt powder is composed of hawthorn, tangerine peel and fried malt, and the mass ratio of the hawthorn, the tangerine peel and the fried malt is 1:1.2:0.15.

[0044] The present invention also provides a method for preparing the hawthorn dandelion microbubble tablet:

[0045] S1. Raw material pretreatment: Take the formula amount of sorbitol and anhydrous citric acid, crush them into fine powder, pass through an 80-mesh sieve, and dry at 55° C. until the moisture content of the material is less than 4%, thereby obtaining material A; take the formula amount of sodium bicarbonate powder, dry at 55° C. until the moisture content of the material is less than 4%, thereby obtaining material B.

[0046] S2, mixing: the pretreated material A and material B are mixed with the formula amount of hawthorn malt powder, dandelion powder, essence, sucralose, magnesium stearate and Lactobacillus crispatus KT-11 on a machine until the material has a uniform color and no lumps.

[0047] S3. Tablet pressing: Use a circular mold with a diameter of 12 mm to prepare the sample by dry direct pressing method, control the tablet weight to 0.6 g, and obtain a microbubble tablet. The hardness of the sample needs to be controlled within the range of 150-200N to ensure that the tablet shape is complete, the surface is smooth, and the tablet weight is stable.

[0048] S4. Bottling: The above-mentioned microbubble tablets are sieved to remove the fine powder on the surface and packed into customized packaging bottles, 30 tablets / bottle, to obtain the finished product.

[0049] Example 2

[0050] The present embodiment provides a hawthorn dandelion microbubble tablet, wherein each 1000g of the hawthorn dandelion microbubble tablet comprises the following raw materials: 133.3g of hawthorn malt powder, 26.7g of dandelion powder, 415g of sorbitol, 180g of anhydrous citric acid, 150g of sodium bicarbonate, 16.7g of magnesium stearate, 5g of sucralose, 33.3g of tangerine peel essence, and 40g of postbiotics. The hawthorn malt powder is composed of hawthorn, tangerine peel, and fried malt, and the mass ratio of the hawthorn, the tangerine peel, and the fried malt is 1:1.5:0.2.

[0051] The present invention also provides a method for preparing the hawthorn dandelion microbubble tablet:

[0052] S1. Raw material pretreatment: Take the formula amount of sorbitol and anhydrous citric acid, crush them into fine powder, pass through an 80-mesh sieve, and dry at 55° C. until the moisture content of the material is less than 4%, thereby obtaining material A; take the formula amount of sodium bicarbonate powder, dry at 55° C. until the moisture content of the material is less than 4%, thereby obtaining material B.

[0053] S2, mixing: the pretreated material A and material B are mixed with the formula amount of hawthorn malt powder, dandelion powder, essence, sucralose, magnesium stearate and Lactobacillus crispatus KT-11 on a machine until the material has a uniform color and no lumps.

[0054] S3. Tablet pressing: Use a circular mold with a diameter of 12 mm to prepare the sample by dry direct pressing method, control the tablet weight to 0.6 g, and obtain a microbubble tablet. The hardness of the sample needs to be controlled within the range of 150-200N to ensure that the tablet shape is complete, the surface is smooth, and the tablet weight is stable.

[0055] S4. Bottling: The above-mentioned microbubble tablets are sieved to remove the fine powder on the surface and packed into customized packaging bottles, 30 tablets / bottle, to obtain the finished product.

[0056] Example 3

[0057] The present embodiment provides a hawthorn dandelion microbubble tablet, wherein each 1000g of the hawthorn dandelion microbubble tablet comprises the following raw materials: 200g of hawthorn malt powder, 50g of dandelion powder, 400g of sorbitol, 150g of anhydrous citric acid, 100g of sodium bicarbonate, 10g of magnesium stearate, 1g of sucralose, 10g of tangerine peel essence, and 79g of postbiotics. The hawthorn malt powder is composed of hawthorn, tangerine peel, and fried malt, and the mass ratio of the hawthorn, the tangerine peel, and the fried malt is 1:1.8:0.25.

[0058] The present invention also provides a method for preparing the hawthorn dandelion microbubble tablet:

[0059] S1. Raw material pretreatment: Take the formula amount of sorbitol and anhydrous citric acid, crush them into fine powder, pass through a 100-mesh sieve, and dry at 55° C. until the moisture content of the material is less than 4%, thereby obtaining material A; take the formula amount of sodium bicarbonate powder, dry at 55° C. until the moisture content of the material is less than 4%, thereby obtaining material B.

[0060] S2, mixing: the pretreated material A and material B are mixed with the formula amount of hawthorn malt powder, dandelion powder, essence, sucralose, magnesium stearate and Lactobacillus crispatus KT-11 on a machine until the material has a uniform color and no lumps.

[0061] S3. Tablet pressing: Use a circular mold with a diameter of 12 mm to prepare the sample by dry direct pressing method, control the tablet weight to 0.6 g, and obtain a microbubble tablet. The hardness of the sample needs to be controlled within the range of 150-200N to ensure that the tablet shape is complete, the surface is smooth, and the tablet weight is stable.

[0062] S4. Bottling: The above-mentioned microbubble tablets are sieved to remove the fine powder on the surface and packed into customized packaging bottles, 30 tablets / bottle, to obtain the finished product.

[0063] Comparative Example 1

[0064] Compared with Example 2, the only difference of this comparative example is that the ratio of hawthorn, tangerine peel and roasted malt in the hawthorn malt powder is 1:1:0.2.

[0065] Comparative Example 2

[0066] Compared with Example 2, the difference of this comparative example is that the ratio of hawthorn, tangerine peel and roasted malt in the hawthorn malt powder is 0.5:1.5:0.2.

[0067] Comparative Example 3

[0068] Compared with Example 2, the difference of this comparative example is that no postbiotics are added, and the amount of postbiotics is changed to the amount of hawthorn malt powder and dandelion powder corresponding to the ratio of hawthorn malt powder and dandelion powder in Example 2.

[0069] Comparative Example 4

[0070] Compared with Example 2, the difference of this comparative example is only that the added amount of postbiotics is 10g, and according to the ratio of hawthorn malt powder and dandelion powder in Example 2, the missing amount of postbiotics is changed to the corresponding amount of hawthorn malt powder and dandelion powder.

[0071] Comparative Example 5

[0072] Compared with Example 2, the only difference of this comparative example is that Lactobacillus plantarum lp226 is used instead of postbiotics.

[0073] Comparative Example 6

[0074] Compared with Example 2, the difference of this comparative example is that the added amount of dandelion powder is 5 g, and the missing amount of dandelion is replaced by a corresponding amount of hawthorn malt powder.

[0075] Comparative Example 7

[0076] Compared with Example 2, the only difference of this comparative example is that yam powder is used instead of dandelion powder.

[0077] Experimental example

[0078] Population efficacy testing experiment

[0079] After obtaining informed consent from the patients, 220 adults were observed using the hawthorn dandelion microbubble tablets of Examples 1 to 3 of the present invention and Comparative Examples 1 to 7 (the 220 patients were evenly divided into 11 groups, with 20 people in each group), of which 220 patients were healthy, free of any chronic diseases, aged between 18 and 45 years old, used specific toothbrushes and toothpastes for two weeks before the test, and fasted and did not brush their teeth within 12 hours. The method was as follows: a group of blanks was set up, and the blank group did not use any products. The other groups of patients took three hawthorn dandelion microbubble tablets of Examples 1 to 3 of the present invention and Comparative Examples 1 to 7, respectively, and bad breath measurement (OI) was performed 5 minutes and 2 hours after use, respectively. The relevant indicators and test results are shown in Tables 1 and 2 below. No adverse reactions related to the product were observed during the use of the product, and the results are as follows:

[0080] Table 1 Bad breath related indicators

[0081]

[0082] Table 2 Hawthorn dandelion microbubble tablets efficacy test results

[0083] project 5 minutes later 2h later Example 1 0 1 Example 2 0 0 Example 3 0 1 Comparative Example 1 3 4 Comparative Example 2 3 4 Comparative Example 3 2 3 Comparative Example 4 2 3 Comparative Example 5 1 2 Comparative Example 6 1 2 Comparative Example 7 2 3

[0084] According to the above table, compared with Example 2, Comparative Examples 1 and 2 change the ratio of hawthorn, tangerine peel and fried malt in tangerine peel malt powder, and the prepared hawthorn dandelion microbubble tablets have a significantly reduced effect on removing bad breath; Comparative Examples 3 to 4 do not add or reduce the amount of postbiotics added, and the prepared hawthorn dandelion microbubble tablets have a slightly reduced effect on removing bad breath; Comparative Example 5 uses other postbiotics instead of the postbiotics of the present invention, and the prepared hawthorn dandelion microbubble tablets have a slightly reduced effect on removing bad breath; Comparative Example 6 reduces the amount of dandelion powder added, and the prepared hawthorn dandelion microbubble tablets have a slightly reduced effect on removing bad breath; Comparative Example 7 uses yam powder instead of dandelion powder, and the prepared hawthorn dandelion microbubble tablets have a slightly reduced effect on removing bad breath, indicating that the embodiment of the present invention selects hawthorn, fried malt, tangerine peel in a suitable proportion and a combination of postbiotics, and the prepared hawthorn dandelion microbubble tablets have a good effect on removing bad breath.

[0085] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A composition capable of improving oral sub-health, characterized in that: The active raw materials forming the composition are made of 10-20 parts of hawthorn malt powder, 1-5 parts of dandelion and 3-8 parts of postbiotics in parts by mass; wherein the hawthorn malt powder is composed of hawthorn, tangerine peel and fried malt; the mass ratio of the hawthorn, the tangerine peel and the fried malt is 1:1.2-1.8:0.15-0.25; and the postbiotic is Lactobacillus crispatus KT-11.

2. A hawthorn dandelion microbubble tablet, characterized in that: The raw materials include the composition capable of improving oral sub-health as claimed in claim 1.

3. The hawthorn dandelion microbubble sheet according to claim 2, characterized in that: Every 100g of the hawthorn and dandelion microbubble tablets comprises the following raw materials in different mass fractions: 10-20% hawthorn malt powder, 1-5% dandelion, 40-50% diluent, 15-25% acid source disintegrant, 10-20% alkaline source disintegrant, 1-4% lubricant, 0.1-1% sweetener, 1-5% flavor and 3-8% postbiotics.

4. The hawthorn dandelion microbubble sheet according to claim 2, characterized in that: Every 100g of hawthorn and dandelion microbubble tablets includes the following raw materials in different mass fractions: 13.33% hawthorn malt powder, 2.67% dandelion, 41.5% diluent, 18% acid source disintegrant, 15% alkali source disintegrant, 1.67% lubricant, 0.5% sweetener, 3.33% flavor and 4% postbiotics.

5. The hawthorn dandelion microbubble sheet according to claim 3 or 4, characterized in that: The diluent includes sorbitol; the acid source disintegrant includes anhydrous citric acid; the alkali source disintegrant includes sodium bicarbonate; the lubricant includes magnesium stearate; and the sweetener includes sucralose.

6. A method for preparing the hawthorn dandelion microbubble tablet according to claim 2, characterized in that: include: The raw materials are mixed and then tableted.

7. The preparation method according to claim 6, characterized in that: include: (1) Raw material pretreatment: The diluent and the acid source disintegrant are crushed and sieved, and then dried until the moisture content is less than 4% to obtain material A; Drying the alkaline source disintegrant until the moisture content is less than 4% to obtain material B; (2) Mixing: Mix the material A, the material B, hawthorn malt powder, dandelion powder, flavor, sweetener, lubricant and postbiotics in a machine until the material is visually uniform in color and free of lumps; (3) Dry direct compression tableting is used.

8. The preparation method according to claim 7, characterized in that: include: (1) The aperture of the medium sieve is 60-100 mesh; (2) The mixing conditions are: mixing speed is 15-25 rpm, and mixing time is 15-25 minutes; (3) The hardness of the tablets after medium compression is 150-200N.

Citation Information

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