Traditional Chinese medicine for treating spleen and stomach deficiency syndrome

Abstract

The invention relates to a traditional Chinese medicine for treating spleen and stomach deficiency syndrome, which can effectively solve the medication problem of spleen and stomach deficiency syndrome. The technical solution is that the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-30 parts of ginseng, 20-30 parts of trifoliate radish, 40-60 parts of citron, 80-120 parts of radish seeds, 20-30 parts of daisy flower, 40-60 parts of galangal, 20-30 parts of piper longum, 20-30 parts of alkyl oxyphylla, 20-30 parts of burdock seeds and 10-30 parts of vitamin B1. The traditional Chinese medicine can quickly relieve or release pain, eliminate abdominal distension, improve spleen and stomach function, utilize the mutual synergy of medicinal properties between multiple traditional Chinese medicinal materials, fundamentally treat the symptoms of spleen and stomach deficiency, is not easy to recur, has good use effect, and is an innovation in medicine for treating spleen and stomach deficiency syndrome.

Description

1. Technical Field

[0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine for treating spleen and stomach deficiency syndrome. 2. Background Technology

[0002] "Improper diet, overwork, long-term worry, insufficient endowment, old age, recovery from a serious illness, and improper care can all lead to weak spleen and stomach. The symptoms of spleen and stomach deficiency are: reduced appetite, abdominal distension after eating, limb edema, loose stools, fatigue, shortness of breath, laziness, sallow complexion, dry mouth and throat, low fever, night sweats, hot hands and feet, dry stools, watery mouth, cold pain in the abdomen, preference for warmth and desire for pressure, cold limbs, chronic diarrhea, and chronic dysentery. Women may have thin leucorrhea and cold pain in the lower abdomen.

[0003] Spleen and stomach weakness is a very common disease in real life. The course of the disease is long, which brings a lot of pain and inconvenience to patients in life and work. There are various kinds of medicines on the market, including Western medicine and Chinese patent medicine. Western medicine has a single ingredient and a single efficacy, and cannot fundamentally solve the problem of treating comprehensive diseases. It is also expensive and has great side effects. Most chemical drugs are harmful to the kidneys and are not suitable for the weak and the elderly. Some patients will experience worsening of their condition, which is not satisfactory in terms of treatment effect and treatment cost. Traditional Chinese medicine has significant advantages in treating spleen and stomach weakness, dampness in the spleen and stomach, spleen and stomach disharmony, abdominal distension, loss of appetite, tasteless mouth, vomiting and nausea, belching and acid regurgitation, and heaviness of limbs. The main prescriptions include Liujunzi Decoction and Shenling Baizhu Powder, both of which are traditional Chinese medicines. There are many deficiencies in taking and transporting. Other Chinese patent medicines on the market either have precious medicinal materials or limited efficacy, and are prone to relapse after treatment. Therefore, it is imperative to develop a drug preparation with small side effects, quick effect, short treatment course, high cure rate, small dosage, low price, and convenient use. III. Summary of the invention

[0004] In view of the above situation, in order to solve the defects of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine for treating spleen and stomach deficiency syndrome, which can effectively solve the medication problem of spleen and stomach deficiency syndrome.

[0005] The technical solution solved by the present invention is that the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 20-30 parts of ginseng, 20-30 parts of trifoliate radish, 40-60 parts of citron, 80-120 parts of radish seeds, 20-30 parts of daisy flower, 40-60 parts of galangal, 20-30 parts of piper longum, 20-30 parts of alkyl oxyphylla, 20-30 parts of burdock seeds and 10-30 parts of vitamin B1.

[0006] The preparation method of the traditional Chinese medicine comprises the following steps:

[0007] 1) Ginseng is placed in a grinder and crushed into Chinese medicinal powder and passed through a sieve with an inner diameter of 75 μm, mixed evenly, and sterilized at 115-130° C. for 20-40 minutes to obtain sterilized ginseng powder for later use;

[0008] 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils;

[0009] 3) Boil the residues of citron, radish seed, and burdock seed with three-edged sword, daidaihua, galangal, yiqi, and longpiper in water twice, add 9-11 times the weight of the eight raw materials of water for the first time, extract for 1.5-2.5 hours; filter, add 7-9 times the weight of the eight raw materials of water to the residues, extract for 1-2 hours, filter, combine the two filtrates; decompress and concentrate to a thick paste with a relative density of 1.35-1.40 at 70° C.-90° C.;

[0010] 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

[0011] The Chinese medicine of the present invention can quickly relieve or eliminate pain, eliminate abdominal distension, improve spleen and stomach function, and utilizes the mutual synergy of medicinal properties among multiple Chinese medicinal materials to fundamentally treat the symptoms of spleen and stomach deficiency. It is not easy to recur and has a good use effect. It is an innovation in medicine for treating spleen and stomach deficiency syndrome. 4. Specific implementation methods

[0012] The specific implementation modes of the present invention are further described in detail below in conjunction with the embodiments.

[0013] Example 1

[0014] The present invention can be prepared from the following raw materials in parts by weight: 20 parts of ginseng, 20 parts of trifoliate radish, 40 parts of citron, 80 parts of radish seeds, 20 parts of daidai hua, 40 parts of galangal, 20 parts of longan, 20 parts of yiqi, 20 parts of burdock seeds and 10 parts of vitamin B1;

[0015] The method comprises the following steps: 1) placing ginseng in a grinder and crushing the ginseng into a Chinese medicinal powder and passing the powder through a sieve with an inner diameter of 75 μm, mixing the powder evenly, and sterilizing the powder at 115° C. for 30 minutes to obtain a sterilized ginseng powder for later use;

[0016] 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils;

[0017] 3) Boil the residues of citron, radish seeds, and burdock seeds with three-edged sword, daidaihua, galangal, yiqi, and longpiper in water twice, add 11 times the weight of the eight raw materials of water for the first time, extract for 1.5 hours; filter, add 7 times the weight of the eight raw materials of water to the residues, extract for 2 hours, filter, combine the two filtrates; concentrate under reduced pressure to 80° C. to measure a thick paste with a relative density of 1.35 to 1.40;

[0018] 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

[0019] Example 2

[0020] In the specific implementation of the present invention, it can also be made from the following raw materials in parts by weight: 25 parts of ginseng, 25 parts of trifoliate radish, 50 parts of citron, 100 parts of radish seeds, 25 parts of galangal, 50 parts of galangal, 25 parts of piper longum, 25 parts of alkyl oxyphylla, 25 parts of burdock seeds and 20 parts of vitamin B1.

[0021] 1) pulverizing ginseng in a grinder to form Chinese medicinal powder and passing the powder through a sieve with an inner diameter of 75 μm, mixing the powder evenly, and sterilizing the powder at 120° C. for 30 minutes to obtain sterilized ginseng powder for later use;

[0022] 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils;

[0023] 3) Boil the residues of Citron, Radish Seed, Arctium Lappa with Trillium, Daidaihua, Kaempferia galanga, Alpinia oxyphylla, and Piper longum in water twice, add 10 times the weight of the eight raw materials of water for the first time, extract for 2 hours; filter, add 8 times the weight of the eight raw materials of water to the residues, extract for 1.5 hours, filter, combine the two filtrates; concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 at 80°C;

[0024] 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

[0025] Example 3

[0026] When the present invention is implemented, it can also be made from the following raw materials in parts by weight: 30 parts of ginseng, 30 parts of trifoliate radish, 60 parts of citron, 120 parts of radish seeds, 30 parts of daidai hua, 60 parts of kaempferia galanga, 30 parts of longan, 30 parts of yiqi, 30 parts of burdock seeds and 30 parts of vitamin B1;

[0027] The method comprises the following steps: 1) placing ginseng in a grinder and crushing the ginseng into a Chinese medicine powder and passing the powder through a sieve with an inner diameter of 75 μm, mixing the mixture evenly, and sterilizing the mixture at 125° C. for 20 minutes to obtain a sterilized ginseng powder for later use;

[0028] 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils;

[0029] 3) Boil the residues of citron, radish seeds, and burdock seeds with Trillium, daidaihua, galangal, yiqi, and longpiper in water twice, add 9 times the weight of the eight raw materials of water for the first time, and extract for 2.5 hours; filter, add 9 times the weight of the eight raw materials of water to the residues, extract for 1 hour, filter, combine the two filtrates; concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 at 90°C;

[0030] 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

[0031] Among the above medicines, ginseng is sweet, slightly bitter, and slightly warm. It enters the spleen, lung, heart, and kidney meridians. It greatly replenishes vital energy, restores the pulse and consolidates the body, replenishes the spleen and strengthens the menstrual period, promotes the production of body fluid and nourishes blood, and calms the mind and improves intelligence. It is used for physical weakness and weakness, cold limbs and weak pulse, spleen deficiency and poor appetite, lung deficiency and wheezing and coughing, thirst due to loss of body fluid, internal heat and thirst, qi and blood deficiency, long-term illness and weakness, palpitations and insomnia, impotence and cold uterus.

[0032] Pharmacological studies have shown that ginseng has the following effects:

[0033] 1. Ginseng has a stimulating effect on the nervous system, especially the higher central nervous system. It can enhance the analytical function of the brain and improve sleep and mood. It has a significant therapeutic effect on patients with mental illness. Regular consumption can significantly enhance intelligence.

[0034] 2. Ginseng can enhance the body's defense against various harmful stimuli.

[0035] 3. Ginseng can stimulate the secretion efficiency of the endocrine system, lower blood sugar, and has a certain inhibitory effect on diabetes.

[0036] 4. Appropriate doses of ginseng can increase the contractility and frequency of the heart, excite the heart, speed up blood circulation, promote metabolism in the body, and thus adjust the body's nutritional status and physical decline.

[0037] Trigonum multiflorum: pungent, bitter, neutral. Enters the liver and spleen meridians. Breaks blood and promotes qi circulation, eliminates stagnation and relieves pain. Used for symptomatic lumps, dysmenorrhea, amenorrhea due to blood stasis, chest pain, and bloating and pain due to food stagnation.

[0038] Pharmacological studies have shown that Tripterygium wilfordii has the following effects:

[0039] 1. Breaking up blood and promoting qi circulation: Sanleng can break up qi in the blood and belongs to the blood part of the liver meridian. It can eliminate bad blood, replenish labor, regulate menstruation, and treat flatulence. It is often used to treat women's blood disorders and menstrual retention. The medicinal properties are not very strong and the effect is small and fast.

[0040] 2. Analgesia: Trillium is often used clinically to treat postpartum abdominal pain and bloating in parturient women. It mainly utilizes the blood circulation, blood stasis and analgesic effects of Trillium. It can also promote the disappearance of postpartum lumps and accelerate the absorption of blood clots in the abdominal cavity. It is one of the commonly used gynecological medicines.

[0041] 3. Digestion: Trigonella ternata tastes bitter, pungent and sweet. In traditional Chinese medicine, bitterness is used for purgation, pungentness can disperse, and sweetness can harmonize and enter the spleen. Many endocrine disorders are caused by blood stasis, qi stagnation, and food stagnation. Therefore, Trigonella ternata has the effect of digestion and can treat all stagnation symptoms.

[0042] 4. Anti-cancer: In clinical practice, Trillium is often used to treat primary liver cancer, mainly because the extract of Trillium has a strong inhibitory effect on sarcoma cancer cells, and can also strengthen the stomach and relieve pain, and has a good comprehensive therapeutic effect on cancer patients.

[0043] Citron: pungent, bitter, sour, warm. Enters the liver, spleen, stomach, and lung meridians. Soothes the liver and regulates qi, harmonizes the stomach and relieves pain, dries dampness and resolves phlegm. Used for liver and stomach qi stagnation, chest and flank pain, stomach fullness, loss of appetite and vomiting, and cough with phlegm.

[0044] Pharmacological studies have shown that bergamot has the following effects:

[0045] 1. Antiasthmatic and expectorant effects: Buddha's hand decoction can counteract the contraction of the isolated guinea pig trachea caused by histamine.

[0046] 2. Effect on gastric and intestinal smooth muscle: The alcohol extract of this product has a significant inhibitory effect on the isolated intestine of rats and rabbits.

[0047] 3. The central nervous system inhibitory effect can also significantly prolong the sleeping time of mice induced by sodium pentobarbital, and prolong the lethal time of strychnine convulsions and the occurrence time and lethal time of convulsions caused by pentylenetetrazol or caffeine, and can reduce their mortality rate.

[0048] 4. Effect on the cardiovascular system: Bergamot alcohol extract has the effect of dilating coronary blood vessels and increasing coronary blood flow. At high concentrations, it inhibits myocardial contraction, slows heart rate, lowers blood pressure, prolongs the survival time of mice under hypoxia, and protects experimental myocardial ischemia.

[0049] 5. Anti-inflammatory and antiviral effects.

[0050] 6. Promote the secretion of digestive juice.

[0051] Radish seeds: pungent, sweet, neutral. Enters the lung, spleen, and stomach meridians. Helps digestion and relieves bloating, lowers qi and resolves phlegm. Used for food stagnation, abdominal distension and pain, constipation, stagnation of stool, diarrhea, phlegm-congested wheezing and coughing.

[0052] Pharmacological studies have shown that radish seeds have the following effects: helping digestion and relieving bloating, lowering qi and resolving phlegm, resisting pathogenic microorganisms, detoxifying, lowering blood pressure, affecting gastrointestinal motility, and treating senile constipate , used raw to induce sputum, and fried to resolve phlegm and relieve asthma.

[0053] Daidaihua: sweet, slightly bitter, neutral. Regulates qi, relieves chest tightness, and stimulates appetite. Used for chest and abdominal distension, nausea, and loss of appetite.

[0054] Pharmacological studies have shown that Daidaihua has the following effects:

[0055] 1. Daidaihua is rich in Flavonoids Flavonoid components, hesperidin and naringin have anti-inflammatory effects

[0056] 2. Limonene and other ingredients in the volatile oil of Daidaihua inhibit Trichophyton rubrum At the same time as skin pathogens and molds, Candida albicans , Pseudomonas aeruginosa , Escherichia coli , Staphylococcus aureus It also has an inhibitory effect on bacteria such as chlorella. Essential Oils for Gram-negative bacteria It also has an inhibitory effect on Gram-positive bacteria, and at the same time, flavonoids from the herb also have a good inhibitory effect on Gram-negative bacteria.

[0057] 3. Flavonoids Many of them have anti-tumor activity, and the total flavonoids in the herb show selective cytotoxic effects, anti-proliferation and induction of apoptosis.

[0058] 4. The synephrine contained in the herb can promote gastrointestinal motility in mice. It has no effect on gastric emptying in normal mice, but can accelerate the small intestinal motility of normal mice.

[0059] Kaempferia galanga: pungent, warm. Enters the stomach meridian. Promotes qi and warms the middle, helps digestion, relieves pain. Used for chest distension, cold pain in the bladder and abdomen, and indigestion.

[0060] Pharmacological studies have shown that Kaempferia galanga has the following effects:

[0061] 1. Warming the middle and aiding food is one of the important functions of galangal. It has a good effect on human chest fullness and abdominal cold pain. It has a mild nature and can regulate the spleen and stomach, improve the digestive ability of the body, and reduce the occurrence of symptoms.

[0062] 2. Kaempferia galanga can reduce swelling and relieve pain. It also has obvious effects on human joint swelling and pain and rheumatism. It can be used together with other Chinese medicinal materials to make the effect more outstanding. In addition, Kaempferia galanga can also relieve toothache. When people have toothache, they can directly grind Kaempferia galanga into powder and apply it externally to relieve pain.

[0063] 3. The root decoction has different degrees of inhibitory effect on 10 common pathogenic fungi in test tubes, including Trichophyton schrenkiana and its Mongolian variant, Trichophyton concentricum, and Trichophyton violaceum.

[0064] Piper longum: pungent, hot. Enters the stomach and large intestine meridians. Warms the middle and dispels cold, relieves qi and relieves pain. Used for cold pain in the abdomen, vomiting, diarrhea, cold stagnation, chest pain, headache, and toothache.

[0065] Pharmacological studies have shown that Piper longum has the following effects:

[0066] 1. The effects of Piper longum on myocardial nutritional blood flow in mice at different doses are very different.

[0067] 2. The volatile oil contained in Piper longum has inhibitory effects on Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Shigella dysenteriae, Salmonella typhi T and B, Sarcoma vulgaris, influenza virus, etc.

[0068] 3. Intraperitoneal injection of Piper longum into rats can significantly counteract convulsions, electric convulsions and "audiogenic seizures" caused by pentylenetetrazol. The number of activities of mice decreased 5 minutes after injection of Piper longum, which has a synergistic effect with sodium thiopental and can counteract the depressive effect of morphine and sodium pentobarbital on respiration.

[0069] 4. The unsaponifiable matter of Piper longum volatile oil (OPUM) can significantly reduce the serum TC and liver Ch content of endogenous and exogenous hypercholesterolemia mice, and the Ch-lowering effect is proportional to the dose.

[0070] 5. Piper longum can inhibit the tension and contraction of the ileum of rabbits and rats. Its ethanol extract has a significant protective effect on experimental gastric ulcers and also has a significant inhibitory effect on the amount of gastric juice and the total acidity of gastric juice.

[0071] Yizhi: pungent, warm. Enters the spleen and kidney meridians. Warms the kidney, consolidates the essence, reduces urine, warms the spleen, stops diarrhea, and controls saliva. Used for kidney deficiency, enuresis, frequent urination, turbid spermatorrhea, spleen cold diarrhea, cold pain in the abdomen, and excessive saliva in the mouth.

[0072] Pharmacological studies have shown that Nootropics has the following effects:

[0073] 1. It has the effect of antagonizing calcium activity.

[0074] 2. It has a cardiotonic effect.

[0075] 3. It has anti-cancer and ileum contraction control effects.

[0076] 4. The alcohol extract of Alpinia oxyphylla fruit has the effect of inhibiting prostaglandins.

[0077] 5. For rats Gastric ulcer It has a significant inhibitory effect.

[0078] Burdock seeds: pungent, bitter, cold. Enter the lung and stomach meridians. Disperse wind-heat, clear the lungs and relieve rashes, detoxify and relieve sore throat. Used for wind-heat colds, coughs with sputum, measles, rubella, sore throat, mumps, erysipelas, carbuncles, sores and ulcers.

[0079] Pharmacological studies have shown that burdock has the following effects:

[0080] 1. Antibacterial and antiviral effects: The water extract of burdock seeds (1:2) had an in vitro effect on Trichophyton cocoon, Trichophyton concentricum, Trichophyton spp., Microspore tinea audouinensis, Microspore tinea woolly, Epidermophyton inguinale, Epidermophyton rubrum, Nocardia asteroides, rust It has antibacterial effect on 9 pathogenic fungi such as Trichophyton microsporum.

[0081] 2. Burdock extract can significantly and long-term lower blood sugar in rats and improve their tolerance to carbohydrates.

[0082] 3. The guinea pig colon strip test proved that trachelospermum parkii aglycone has a significant calcium antagonist effect and can inhibit the contraction caused by high potassium.

[0083] Vitamin B1: White crystals or crystalline powder; has a slight peculiar odor and tastes bitter.

[0084] Pharmacological studies have shown that vitamin B1 has the following effects: Vitamin B1 is a cofactor of key enzymes in glucose metabolism and plays an important role in maintaining the balance of oxidative metabolism in the brain. Vitamin B1 is an important biologically active substance that maintains the normal function of the nervous, cardiac and digestive systems.

[0085] The raw material components of the Chinese medicine of the present invention are an organic whole, and none of them can be missing. In the process of prescription screening research, it was found that reducing any raw material component in the above-mentioned composition, or replacing the raw material component of the pharmaceutical composition of the present invention with a raw material drug with similar medicinal properties, the effect of the drug combination was significantly reduced; adding other raw material components on the basis of the composition did not significantly improve the overall effect of the composition.

[0086] The present invention is directed to a Chinese medicine composition for spleen and stomach deficiency syndrome, i.e., poor appetite, fatigue, abdominal distension after eating or in the afternoon, abnormal stool (loose, rotten, first hard then loose, sometimes hard and sometimes loose) as the main symptoms, and fatigue, bland mouth without thirst, persistent abdominal pain, nausea and vomiting, abdominal distension, intestinal rumbling, sallow complexion, edema, weak defecation, thin white fur, weak pulse, etc. as the secondary symptoms, with ginseng as the main drug, by greatly replenishing vital energy, tonifying the spleen and lungs, improving the symptoms of spleen and stomach deficiency and indigestion; with ginseng as the main drug, the Chinese medicine composition is used for improving the symptoms of spleen and stomach deficiency and indigestion by greatly replenishing vital energy, tonifying the spleen and lungs, and improving the symptoms of food indigestion; with ginseng as the main drug, the Chinese medicine composition is used for improving the symptoms of spleen and stomach deficiency and ... Hand and Daidaihua are the assistant drugs, which can relieve chest tightness, nausea and vomiting by soothing the liver and regulating qi, widening the chest and stimulating appetite; Radish seeds, Trillium and Sannai are the adjuvant drugs, which can eliminate accumulation and swelling, promote qi and lower qi, relieve abdominal pain, loose stools, and loss of appetite; Piper longum, Alpinia oxyphylla and Arctium are the guiding drugs, which can warm the spleen and stop diarrhea, relieve qi and stop pain, and play the role of strengthening the spleen and stomach, with the advantages of high efficacy and no toxic side effects. The relevant clinical data are as follows:

[0087] 1. Case selection

[0088] 1. Case selection criteria:

[0089] The inclusion criteria include meeting two main symptoms, or one main symptom plus two secondary symptoms.

[0090] 2. A total of 136 patients who met the inclusion criteria and obtained informed consent were selected for this efficacy observation, of which 59% were male patients. They were randomly divided into a treatment group of 66 cases, including 40 males and 26 females, aged 20-60 years old, and a control group of 70 cases, including 40 males and 30 females, aged 20-60 years old. There was no significant difference between the two groups of patients in terms of gender, age, etc.

[0091] 2. Treatment Plan

[0092] Control group: Ginseng Jianpi Pills: Oral administration, with warm water, 8g each time, twice a day. 7 days as a course of treatment, 2 courses of treatment for statistical efficacy;

[0093] Treatment group: taking the Chinese medicine composition pills prepared in Example 2 of the present invention, taken with boiled water, 10 pills at a time (each 10 pills is equivalent to 4g of the decoction piece), 3 times a day, 7 days as a course of treatment, and the therapeutic effect was statistically analyzed after 2 courses of treatment.

[0094] III. Efficacy evaluation criteria

[0095] Cure: The clinical symptoms and signs of spleen and stomach deficiency syndrome disappear or basically disappear, and the syndrome score decreases by ≥95%.

[0096] Markedly effective: The clinical symptoms and signs of spleen and stomach deficiency syndrome were significantly improved, and the syndrome score was reduced by ≥70%.

[0097] Effective: The clinical symptoms and signs of spleen and stomach deficiency syndrome are improved, and the syndrome score is reduced by ≥30%.

[0098] Ineffective: The clinical symptoms and signs of spleen and stomach deficiency syndrome were not significantly improved, or even aggravated, and the syndrome score decreased by less than 30%.

[0099] Calculation formula (nimodipine method): [(score before treatment - score after treatment) ÷ score before treatment] × 100%.

[0100] 4. Statistical Processing

[0101] After treatment, the efficacy results showed that among the 66 cases in the treatment group, 37 patients were cured, 18 were significantly effective, 6 were effective, and the total effective rate was 92.42%; among the 70 cases in the control group, 33 patients were cured, 19 were significantly effective, 9 were effective, and the total effective rate was 87.14%. There was a significant difference in the treatment effects between the two groups, and the treatment effect of the treatment group was significantly better than that of the control group (p<0,05), as shown in Table 1 for details.

[0102] Table 1: Comparison of treatment effects between the two groups of patients (n, %)

[0103]

[0104] 5. Typical Cases

[0105] 1. Mr. Wang, male, 50 years old, civil servant, suffered from abdominal distension, fatigue, loose stools and occasional abdominal pain due to eating unclean food. He was given the above-mentioned treatment group of drugs for 3 days, and his symptoms improved significantly. After taking it for 5 days, all symptoms disappeared and he was cured.

[0106] 2. Zhang, female, 47 years old, suffered from chronic gastritis, fatigue, abdominal pain, accompanied by nausea, vomiting, and persistent intestinal rumbling. After taking the above-mentioned treatment group for 7 days, the symptoms improved significantly, and the clinical symptoms and signs improved significantly after 14 days of taking the medicine.

[0107] 3. Mr. Li, male, 21 years old, student, had abdominal distension after lunch, abnormal stool that was first hard and then loose, persistent abdominal pain, and sallow complexion. He was given the above-mentioned treatment group drugs for 2 days, and his symptoms improved significantly. After 6 days of taking the drugs, all symptoms disappeared and he was cured.

[0108] While conducting the above experiment on Example 2, the same experiment was also conducted on other examples, and the same or similar results were obtained, indicating that the product quality is good and the therapeutic effect is stable and reliable, which will not be listed one by one here.

[0109] VI. Adverse Reactions

[0110] No adverse reactions were found in all observed cases, and there were no abnormal changes in blood, urine, stool routine and electrocardiogram before and after medication, indicating that the clinical medication is safe.

[0111] VII. Conclusion

[0112] To sum up, the present invention targets the etiology of spleen and stomach deficiency syndrome, focuses on strengthening the spleen and stomach, scientifically and rationally formulates the drug components, supports and cooperates with each other, exerts the therapeutic effect of the drug while reducing side effects on the body, adopts different technical processes according to the properties of the effective ingredients of different medicinal materials, and greatly improves the content of effective ingredients compared with similar products, fully exerts the role of the effective ingredients of the drug, has scientific and reasonable compatibility, the components support each other, the medication is safe, the efficacy is stable and reliable, and it is easy to produce and prepare. It is an innovation in the drug for treating spleen and stomach deficiency syndrome, has practical clinical significance and promotion and application value, and has huge economic and social benefits.

[0113] It should be pointed out that the above is only a preferred embodiment of the present invention and does not limit the present invention in any form. Any technician familiar with the profession can make changes or modify the technical contents disclosed above into equivalent embodiments with equivalent changes without departing from the scope of the technical solution of the present invention, which all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine for treating spleen and stomach deficiency syndrome, characterized in that: The Chinese medicine is prepared from the following raw materials in parts by weight: 20-30 parts of ginseng, 20-30 parts of trifoliate radish, 40-60 parts of citron, 80-120 parts of radish seeds, 20-30 parts of daisy flower, 40-60 parts of galangal, 20-30 parts of piper longum, 20-30 parts of oxyphylla, 20-30 parts of burdock seeds and 10-30 parts of vitamin B1; The preparation method of the traditional Chinese medicine comprises the following steps: 1) Grind ginseng in a grinder to make Chinese medicinal powder and pass it through a sieve with an inner diameter of 75µm. Mix well and sterilize at 115-130℃ for 20-40 minutes to obtain sterilized ginseng powder for later use. 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils; 3) Boil the residues of citron, radish seed, burdock seed, Trillium, daidaihua, galangal, yiqi and longpiper with water twice, add 9-11 times the weight of the eight raw materials of water for the first time, extract for 1.5-2.5 hours; filter, add 7-9 times the weight of the eight raw materials of water to the residues, extract for 1-2 hours, filter, combine the two filtrates; concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 at 70°C-90°C; 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

2. The Chinese medicine for treating spleen and stomach deficiency syndrome according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 20 parts of ginseng, 20 parts of trifoliate radish, 40 parts of citron, 80 parts of radish seeds, 20 parts of daisy flower, 40 parts of galangal, 20 parts of piper longum, 20 parts of alkyl oxyphylla, 20 parts of burdock seeds and 10 parts of vitamin B1; Among them, 1) pulverizing ginseng in a pulverizer to grind into Chinese medicinal powder and passing through a sieve with an inner diameter of 75 µm, mixing evenly, and sterilizing at 115°C for 30 minutes to obtain sterilized ginseng powder for later use; 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils; 3) Boil the residues of Citron, Radish Seed, and Arctium Lappa with Trillium, Daidaihua, Kaempferia galanga, Alpinia oxyphylla, and Piper longum in water twice. For the first decoction, add 11 times the weight of the eight raw materials of water and extract for 1.5 hours; filter, add 7 times the weight of the eight raw materials of water to the residues and extract for 2 hours, filter, combine the two filtrates, and concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 at 80°C; 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

3. The Chinese medicine for treating spleen and stomach deficiency syndrome according to claim 1, characterized in that, The medicine is prepared from the following raw materials in parts by weight: 25 parts of ginseng, 25 parts of trifoliate radish, 50 parts of citron, 100 parts of radish seeds, 25 parts of daidai hua, 50 parts of galangal, 25 parts of piper longum, 25 parts of alkyl oxyphylla, 25 parts of burdock seeds and 20 parts of vitamin B1; Among them, 1) pulverizing ginseng in a pulverizer to grind into Chinese medicine powder and passing through a sieve with an inner diameter of 75 µm, mixing evenly, sterilizing at 120° C. for 30 minutes to obtain sterilized ginseng powder for later use; 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils; 3) Boil the residues of Citron, Radish Seed, and Arctium Lappa with Trillium, Daidaihua, Kaempferia galanga, Alpinia oxyphylla, and Piper longum in water twice, add 10 times the weight of the eight raw materials of water for the first time, extract for 2 hours; filter, add 8 times the weight of the eight raw materials of water to the residues, extract for 1.5 hours, filter, combine the two filtrates; concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 at 80°C; 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

4. The Chinese medicine for treating spleen and stomach deficiency syndrome according to claim 1, characterized in that: The invention is prepared from the following raw materials in parts by weight: 30 parts of ginseng, 30 parts of trifoliate radish, 60 parts of citron, 120 parts of radish seeds, 30 parts of daisy flower, 60 parts of galangal, 30 parts of piper longum, 30 parts of alkyl oxyphylla, 30 parts of burdock seeds and 30 parts of vitamin B1; Among them, 1) pulverizing ginseng in a pulverizer to grind into Chinese medicinal powder and passing through a sieve with an inner diameter of 75 µm, mixing evenly, and sterilizing at 125° C. for 20 minutes to obtain sterilized ginseng powder for later use; 2) extracting volatile oil components from bergamot, radish seeds and burdock seeds by steam distillation to obtain bergamot, radish seeds and burdock seeds volatile oils; 3) Boil the residues of Citron, Radish Seed, and Arctium Lappa with Trillium, Daidaihua, Kaempferia galanga, Alpinia oxyphylla, and Piper longum in water twice, add 9 times the weight of the eight raw materials of water for the first time, extract for 2.5 hours; filter, add 9 times the weight of the eight raw materials of water to the residues, extract for 1 hour, filter, combine the two filtrates; concentrate under reduced pressure to a thick paste with a relative density of 1.35-1.40 at 90°C; 4) Add the thick paste obtained in step 3) to the sterilized ginseng powder obtained in step 1) and the volatile oils of citron, radish seeds and burdock seeds obtained in step 2), and finally add vitamin B1, mix well, make pills, and polish to obtain the product.

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