A whole-pipeline automatic sterilization process for traditional Chinese veterinary medicine extraction

Abstract

This invention belongs to the technical field of traditional Chinese medicine extraction equipment, specifically relating to an automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction. This application modifies the entire pipeline of traditional Chinese veterinary medicine extraction to meet the requirements of high-temperature and high-pressure steam sterilization. Before the extraction of traditional Chinese veterinary medicine, high-temperature and high-pressure steam is used to sterilize the entire pipeline. Then, the extraction temperature in the extraction tank is controlled to ensure the sterilization of the extract, thereby ensuring that the final oral liquid meets the sterilization requirements. This saves on the terminal sterilization process and allows for direct filling with non-high-temperature resistant packaging, greatly saving manufacturing costs.

Description

Technical Field

[0001] This invention belongs to the technical field of traditional Chinese medicine extraction equipment, specifically relating to an automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction. Background Technology

[0002] The solutions extracted from traditional Chinese veterinary medicines are easily contaminated with bacteria during pipeline transportation, storage, and bottling, especially ubiquitous yeasts, molds, and Bacillus subtilis. This can lead to losses such as gas buildup, rancidity, shortened shelf life, and product defects in the finished product. To ensure the quality stability of the products, current production processes mostly use terminal sterilization to kill microorganisms.

[0003] Current processes for traditional Chinese medicine oral liquid products often employ moist heat sterilization for terminal sterilization. Moist heat sterilization includes autoclaving, flowing steam sterilization, and boiling sterilization, and is commonly used for final sterilization. This involves sterilizing the packaging material containing the oral liquid at high temperatures after filling. This method has a significant sterilization effect, but requires the packaging material to be heat-resistant. For example, Chinese patent document CN103550310A (CN201310524220.X) discloses a method for preparing a hypoglycemic extract oral liquid from Polygonum capitatum, which includes the following process steps: 1) extraction of the hypoglycemic extract from Polygonum capitatum; 2) preparation; 3) filling; 4) sterilization. In this preparation method, the prepared liquid is first filled into a pre-sterilized oral liquid bottle and sealed; then the bottle is boiled in boiling water for 30 minutes, removed, and allowed to stand. The aforementioned terminal sterilization methods require packaging materials to withstand high temperatures, resulting in higher packaging material costs. Furthermore, the oral liquid production process requires a dedicated step for sterilizing the oral liquid products, which not only increases the cost of sterilization equipment but also affects production efficiency.

[0004] Chinese patent document CN110101881A (201910353928.0) discloses a sterilization method in the production of veterinary traditional Chinese medicine oral liquid. The method involves extracting the veterinary traditional Chinese medicine oral liquid according to the formula, concentrating the extract, filtering the concentrate to remove impurities, preparing the filtrate, subjecting the prepared solution to secondary terminal sterilization, and then adjusting the volume of the sterilized solution to the specified amount according to the process, followed by bottling. This patent employs a secondary terminal sterilization method, introducing clean steam at different points in the prepared solution and controlling the solution to a specific temperature and time for sterilization. After sterilization, purified water is added to the prepared solution to adjust the volume to the specified production amount, and after thorough mixing, it is bottled, effectively killing microorganisms in the production materials and ensuring stable product quality. Compared to terminal sterilization, secondary terminal sterilization is not limited by the requirements of product packaging materials, making it more widely applicable in production. However, the aforementioned secondary sterilization method directly uses steam to heat and sterilize the prepared liquid. Since existing equipment cannot maintain stable high pressure, the sterilization temperature can only be maintained below 100 degrees Celsius. However, the inactivation temperature and other conditions vary greatly among different types of bacteria. Directly introducing steam for sterilization during the production process cannot achieve the purpose of inactivation for some heat-resistant bacteria (such as Bacillus subtilis), and fails to meet the corresponding sterilization standards. Furthermore, using high-temperature steam to directly sterilize the prepared liquid can easily affect the efficacy, nutritional components, color, aroma, and taste of the oral liquid. Summary of the Invention

[0005] The purpose of this invention is to solve the above-mentioned problems and provide an automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction. By modifying the entire pipeline of traditional Chinese veterinary medicine extraction to meet the requirements of high-temperature and high-pressure steam sterilization, the entire pipeline is sterilized using high-temperature and high-pressure steam before extraction. Then, the extraction temperature in the extraction tank is controlled to ensure the sterilization of the extract, thereby ensuring that the final oral liquid meets the sterilization requirements. This saves on the terminal sterilization process and allows for direct filling using non-high-temperature resistant packaging, greatly saving manufacturing costs.

[0006] The technical problem to be solved by the present invention is achieved by the following technical solution: an automatic sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction, wherein pneumatic control valves are installed at the inlet and outlet of the tanks in the entire pipeline, pressure balance pipelines communicating with the outside are respectively installed on the tanks in the entire pipeline, and pneumatic valves and sterilization breathing valves are installed on the pressure balance pipelines, wherein the sterilization breathing valves are located at the outlet of the pressure balance pipelines, and temperature sensors and pressure sensors are installed on the tanks in the entire pipeline;

[0007] The fully automated pipeline sterilization process includes the following steps:

[0008] S1. Before the extraction and preparation of traditional Chinese veterinary medicine, the entire pipeline is sterilized by high-temperature and high-pressure steam from one side of the extraction tank according to the preparation process using a steam system. The high-temperature and high-pressure steam temperature is above 120°C and the pressure is above 2 atmospheres.

[0009] S2. After sterilization, the traditional Chinese veterinary medicine is heated and extracted in the extraction tank. The extraction temperature ensures that the extract meets the sterility requirements. After extraction, subsequent separation and concentration are carried out to finally obtain a cooled oral liquid.

[0010] S3. The cooled oral liquid is sent to the aseptic filling workshop through a sterile pipeline for aseptic filling. Aseptic filling is carried out using non-heat-resistant packaging.

[0011] The technical solution of the present invention also includes: the high temperature and high pressure sterilization method in step S1 includes the following steps:

[0012] The high-temperature and high-pressure sterilization method in step S1 includes the following steps:

[0013] S1.1. Close the pneumatic valves on each tank. First, open the pneumatic control valve at the inlet of the first tank to fill it with high-temperature and high-pressure steam. When the temperature and pressure inside the first tank reach the set threshold, open the pneumatic control valve at the outlet of the first tank to allow the high-temperature and high-pressure steam to enter the pipeline and equipment between the next tank and the first tank for sterilization.

[0014] S1.2. Following the method in step S1.1, open the pneumatic control valves corresponding to the inlet and outlet of the tank in sequence to sterilize the subsequent pipelines.

[0015] S1.3 After high-temperature and high-pressure sterilization is completed, close the pneumatic control valves corresponding to the inlet and outlet of each tank in the opposite direction of steam flow, and open the pneumatic valves on each tank. After the pressure in each tank reaches atmospheric pressure, close the pneumatic valves to complete sterilization.

[0016] The technical solution of the present invention also includes: in step S3, the non-heat-resistant packaging is sterilized before entering the aseptic filling workshop.

[0017] The technical solution of this invention also includes: in step S3, the aseptic treatment of non-heat-resistant packaging is carried out by fumigation. A fumigation workshop connected to the aseptic filling workshop is set up, and the non-heat-resistant packaging is directly sent to the aseptic filling workshop after aseptic treatment in the fumigation workshop. The aseptic treatment of non-heat-resistant packaging is carried out directly in the fumigation workshop connected to the aseptic filling workshop using the fumigation method, which can effectively reduce sterilization costs. Furthermore, the fact that the non-heat-resistant packaging can be directly sent to the aseptic filling workshop after aseptic treatment in the fumigation workshop effectively improves production efficiency.

[0018] The technical solution of the present invention also includes: the entire pipeline for the extraction of traditional Chinese veterinary medicine includes an extraction tank, a filter, a centrifuge, a storage tank and a concentrator connected in sequence by pipelines, the concentrator being connected to a receiving storage tank or a sterile receiving room by pipelines, the receiving storage tank or the sterile receiving room being connected to a sterile filling workshop by pipelines, and the concentrator being a vacuum concentrator;

[0019] The inlet of the extraction tank is connected to the steam system, and pneumatic control valves are installed at the inlet and outlet of the extraction tank, the storage tank, the concentrator, the paste collection tank, and the sterile paste collection room.

[0020] The extraction tank, storage tank, concentrator, and paste collection tank are all equipped with pressure balance pipelines that communicate with the outside. The pressure balance pipelines are equipped with pneumatic valves and sterilization breathing valves. The extraction tank, storage tank, concentrator, and paste collection tank are all equipped with temperature sensors and pressure sensors.

[0021] A circulation pump is installed between the filter and the centrifuge, and a concentrate pump is installed on the pipeline between the concentrator and the collection tank or aseptic collection room. The circulation pump pumps the extract filtered by the filter to the centrifuge for separation and purification. The concentrate pump, installed on the pipeline between the concentrator and the collection tank / aseptic collection room, is used to draw the oral liquid from the concentrator into the collection tank or aseptic collection room for aseptic storage. In this invention, the concentrator is a vacuum concentrator. Because the material is concentrated under negative pressure in a vacuum state, the boiling point of the material can be lowered by utilizing ambient pressure, achieving low-temperature depressurization concentration. The equipment operates at a temperature of 45-65℃ throughout the process, and the evaporation temperature can be adjusted at any time according to the different characteristics of the material. Since the heat source of the vacuum concentrator does not exceed 80℃, the temperature of the prepared oral liquid directly meets the filling requirements of non-high-temperature resistant packaging.

[0022] The technical solution of the present invention also includes: the entire pipeline for the extraction of traditional Chinese veterinary medicine also includes a controller;

[0023] The controller is connected to a temperature sensor, a pressure sensor, a pneumatic valve, and a pneumatic control valve, respectively. The pneumatic control valve and the pneumatic valve are both connected to a compressed gas pipeline.

[0024] The controller is used to control the opening and closing of pneumatic valves and pneumatic control valves. By connecting the controller to a temperature sensor, a pressure sensor, a pneumatic valve, and a pneumatic control valve respectively, the controller can control the opening and closing of the pneumatic valves and pneumatic control valves based on whether the values ​​of the temperature sensor and the pressure sensor reach a set threshold. By connecting the pneumatic control valve and the pneumatic valve to a compressed gas pipeline, compressed gas can be used to provide the power for the opening and closing of the pneumatic control valve and the pneumatic valve.

[0025] The technical solution of this invention also includes: pressure check valves are installed on the extraction tank, storage tank, concentrator, and paste collection tank. By installing pressure check valves on the extraction tank, storage tank, concentrator, and paste collection tank, excessive pressure inside the tank can be prevented from causing danger, and excess gas can be discharged to ensure production safety. The technical solution of this invention also includes: the steam system includes a steam generator or a high-pressure boiler. High-pressure, high-temperature steam can be prepared using a steam generator or a high-pressure boiler, preferably a high-pressure boiler, as the extraction of traditional Chinese veterinary medicine itself requires steam, and existing factories generally have high-pressure boilers.

[0026] The technical solution of the present invention also includes: the fumigation workshop includes a fumigation room connected to the aseptic filling workshop, an ultrasonic atomizer, a circulating fan and a temperature control module installed in the fumigation room;

[0027] The fumigation chamber is equipped with an air inlet pipe and an air outlet pipe. The air inlet pipe is equipped with a sterilization filter, and the air outlet pipe is equipped with an exhaust fan and a one-way air outlet valve.

[0028] The fumigation room is equipped with a material inlet sealed door on the side away from the aseptic filling workshop, and the fumigation room is equipped with a material outlet sealed door on the side adjacent to the aseptic filling workshop, which is connected to the clean area of ​​the filling workshop.

[0029] The temperature control module is used to control the temperature of the fumigation chamber. An ultrasonic atomizer is installed inside the fumigation chamber to sterilize non-heat-resistant packaging. The air inside the fumigation chamber is then replaced through inlet and outlet ducts to ensure a sterile environment. The sterilized non-heat-resistant packaging is then delivered to the aseptic filling workshop for use through a sealed outlet door that connects to the clean area of ​​the filling workshop.

[0030] The inventive concept of this invention: Autoclaving can kill all microorganisms, including spores, and is currently the most effective and widely used sterilization method. Typically, oral liquid preparations are sterilized using autoclaving, which kills microorganisms in the oral liquid under high temperature and pressure conditions through moist steam heating. However, existing production processes require autoclaving after the oral liquid is filled, thus placing certain high-temperature resistance requirements on the packaging material, increasing packaging costs. Furthermore, to ensure the production requirements of aseptic workshops, the packaging must be sterile before filling, which is equivalent to requiring two sterilization processes, significantly increasing production costs.

[0031] This application modifies the oral liquid production line to meet the requirements for high-pressure steam sterilization. Before the oral liquid is produced, the entire pipeline for oral liquid production is sterilized by high-pressure steam at high temperature, ensuring that the entire pipeline is in a sterile state before oral liquid production. This ensures that the produced oral liquid meets sterilization standards and can be directly aseptically filled, optimizing the production process. Non-heat-resistant packaging can be used for filling, reducing packaging costs. Furthermore, the subsequent aseptic treatment of non-heat-resistant packaging is more convenient than that of heat-resistant packaging. Sterilization can be carried out by fumigation with disinfectant before entering the aseptic filling workshop, improving production efficiency and reducing the investment in high-temperature sterilization equipment.

[0032] Compared with the prior art, the beneficial effects of the present invention are as follows: By setting pneumatic control valves at the inlet and outlet of the tank in the entire pipeline for the extraction of traditional Chinese veterinary medicine, and by setting temperature and pressure sensors on the tank in the entire pipeline, the present invention can ensure that the tank and pipeline are in a sealed state during the steam filling process, thereby achieving control of the pressure and temperature inside the tank and pipeline; moreover, by setting a pressure balancing pipeline connected to the outside on the tank in the entire pipeline, and by setting pneumatic valves and sterilization breathing valves on the pressure balancing pipeline, aseptic cooling can be achieved after sterilization, avoiding the generation of negative pressure inside the tank while preventing the re-entry of bacteria-containing air into the tank or pipeline.

[0033] Before the extraction and preparation of traditional Chinese veterinary medicine, this invention utilizes a steam system to sequentially sterilize the entire pipeline from one side of the extraction tank using high-temperature and high-pressure steam according to the preparation process. This ensures that the high-temperature and high-pressure steam temperature is above 120°C and the pressure is above 2 atmospheres, effectively killing heat-resistant bacteria. Furthermore, after sterilization, during the heating and extraction of traditional Chinese veterinary medicine in the extraction tank, the extraction temperature is controlled to ensure that the extract meets the sterility requirements, thereby obtaining a sterile oral liquid. This eliminates the need for terminal sterilization, and the prepared oral liquid has already cooled down, allowing it to be directly packaged using non-heat-resistant packaging, effectively reducing preparation costs. Attached Figure Description

[0034] Figure 1 This is a schematic diagram of the entire pipeline for the extraction of traditional Chinese veterinary drugs as described in this invention;

[0035] Figure 2 This is a schematic diagram of the structure of the fumigation room described in this invention;

[0036] In the diagram, 100 is a pneumatic control valve, 200 is a pneumatic valve, and 300 is a sterilizing breathing valve.

[0037] 1 Extraction tank, 2 Filter, 3 Centrifuge, 4 Storage tank, 5 Concentrator, 6 Collection tank, 7 Collection room, 8 Circulation pump, 9 Concentrate pump, 10 Controller;

[0038] 11. Fumigation room; 12. Ultrasonic atomizer; 13. Circulating fan;

[0039] 1101 Air inlet duct, 1102 Air outlet duct;

[0040] 14. Sterilization filter, 15. Exhaust fan, 16. One-way exhaust valve, 17. Feed sealing door, 18. Discharge sealing door. Detailed Implementation

[0041] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0042] An automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction, such as Figure 1 As shown, pneumatic control valves 100 are installed at the inlet and outlet of the tank in the entire pipeline. Pressure balance pipelines communicating with the outside are installed on the tank in the entire pipeline. Pneumatic valves 200 and sterilization breathing valves 300 are installed on the pressure balance pipelines. The sterilization breathing valve 300 is located at the outlet of the pressure balance pipeline. Temperature sensors and pressure sensors are installed on the tank in the entire pipeline.

[0043] The fully automated pipeline sterilization process includes the following steps:

[0044] S1. Before the extraction and preparation of traditional Chinese veterinary medicine, the entire pipeline is sterilized by high temperature and high pressure steam from one side of the extraction tank 1 according to the preparation process using a steam system. The temperature of the high temperature and high pressure steam is above 120°C and the pressure is above 2 atmospheres.

[0045] S2. After sterilization, the traditional Chinese veterinary medicine is heated and extracted in extraction tank 1. The heating of extraction tank 1 is also carried out using high-pressure and high-temperature steam from the steam system. The extraction temperature ensures that the extract meets the sterility requirements. After extraction, subsequent separation and concentration are carried out to finally obtain a cooled oral liquid.

[0046] S3. The cooled oral liquid is sent to the aseptic filling workshop through a sterile pipeline for aseptic filling. Aseptic filling is carried out using non-heat-resistant packaging.

[0047] The high-temperature and high-pressure sterilization method in step S1 includes the following steps:

[0048] S1.1. Close the pneumatic valves 200 on each tank. First, open the pneumatic control valve 100 at the inlet of the first tank to fill it with high-temperature and high-pressure steam. When the temperature and pressure inside the first tank reach the set threshold, open the pneumatic control valve 100 at the outlet of the first tank to allow the high-temperature and high-pressure steam to enter the pipeline and equipment between the next tank and the first tank for sterilization.

[0049] S1.2. Following the method in step S1.1, open the pneumatic control valves 100 corresponding to the inlet and outlet of the tank in sequence to sterilize the subsequent pipelines.

[0050] S1.3 After high-temperature and high-pressure sterilization is completed, close the pneumatic control valves 100 corresponding to the inlet and outlet of each tank in the opposite direction of steam flow, and open the pneumatic valves 200 on each tank. After the pressure in each tank reaches atmospheric pressure, close the pneumatic valves 200 to complete sterilization.

[0051] In step S3, non-heat-resistant packaging undergoes aseptic treatment before entering the aseptic filling workshop.

[0052] In step S3, the aseptic treatment of non-heat-resistant packaging is carried out by fumigation. A fumigation workshop connected to the aseptic filling workshop is set up. After aseptic treatment in the fumigation workshop, the non-heat-resistant packaging is directly sent to the aseptic filling workshop.

[0053] like Figure 1 As shown, the entire pipeline for extracting traditional Chinese veterinary medicine includes an extraction tank 1, a filter 2, a centrifuge 3, a storage tank 4, and a concentrator 5, connected sequentially by pipelines. The concentrator 5 is connected to a collection tank 6 or a sterile collection room 7 via pipelines. The collection tank 6 or the sterile collection room 7 is connected to a sterile filling workshop via pipelines. The concentrator 5 is a vacuum concentrator. The sterile collection room 7 and the collection tank 6 are respectively connected to the sterile filling workshop via pressure pumps to deliver the prepared oral liquid to the sterile filling workshop.

[0054] The inlet of the extraction tank 1 is connected to the steam system, and pneumatic control valves 100 are installed at the inlet and outlet of the extraction tank 1, the liquid storage tank 4, the concentrator 5, the paste collection storage tank 6, and the sterile paste collection room 7.

[0055] The extraction tank 1, storage tank 4, concentrator 5, and paste collection tank 6 are all equipped with pressure balancing pipelines connecting to the outside environment. These pressure balancing pipelines are equipped with pneumatic valves 200 and sterile breathing valves 300. Temperature sensors and pressure sensors are also installed on each of these components. The sterile breathing valve 300 is a clean breathing apparatus, the pneumatic valve 200 is a clean stainless steel pneumatic ball valve, and the pneumatic control valve 100 is a pneumatic ball valve.

[0056] A circulation pump 8 is installed between the filter 2 and the centrifuge 3, and a concentrate pump 9 is installed on the pipeline between the concentrator 5 and the paste collection tank 6 or the aseptic paste collection room 7.

[0057] The entire pipeline for extracting traditional Chinese veterinary medicine also includes a controller 10.

[0058] The controller 10 is connected to a temperature sensor, a pressure sensor, a pneumatic valve 200, and a pneumatic control valve 100, respectively. Both the pneumatic control valve 100 and the pneumatic valve 200 are connected to a compressed gas pipeline.

[0059] The controller 10 is used to control the opening and closing of the pneumatic valve 200 and the pneumatic control valve 100. The control valve 10 is also connected to the circulating pump 8 and the concentrate pump 9, and is used to control the start and stop of the circulating pump 8 and the concentrate pump 9 and the delivery flow rate.

[0060] Each of the extraction tank 1, storage tank 4, concentrator 5, and paste collection tank 6 is equipped with a pressure check valve.

[0061] The steam system includes a steam generator or a high-pressure boiler.

[0062] like Figure 2 As shown, the fumigation workshop includes a fumigation room 11 connected to the aseptic filling workshop, an ultrasonic atomizer 12, a circulating fan 13 and a temperature control module installed in the fumigation room 11.

[0063] The fumigation chamber 11 is equipped with an air inlet duct 1101 and an air outlet duct 1102. The air inlet duct 1101 is equipped with a sterilization filter 14, and the air outlet duct 1102 is equipped with an exhaust fan 15 and a one-way air outlet valve 16.

[0064] The fumigation room 11 is provided with a material inlet sealing door 17 on the side away from the aseptic filling workshop, and the fumigation room 11 is provided with a material outlet sealing door 18 on the side adjacent to the aseptic filling workshop, which is connected to the clean area of ​​the filling workshop.

[0065] The temperature control module is used to control the temperature of the fumigation room 11.

[0066] Working principle:

[0067] 1. The top of the Chinese medicine extraction and cooking tank (extraction tank 1) is equipped with a sterilization breathing valve 300. The sterilization breathing valve 300 is connected to the tank body with a clean stainless steel pneumatic ball valve to ensure that it remains closed during the Chinese medicine extraction process. After high-temperature sterilization, it will automatically open to prevent negative pressure inside the tank after cooling and environmental bacterial contamination.

[0068] Clean steam enters through the pneumatic ball valve at the bottom of the extraction tank and forms a high-temperature steam environment with a certain pressure inside the tank.

[0069] 2. When the steam pressure in the extraction tank 1 reaches the set threshold, the pneumatic ball valve at the outlet of the extraction tank 1 used to control the pumping opens, and the steam enters the circulation pump 8 in reverse, and then enters the tubular centrifuge 3 in reverse. The pneumatic valve on the pipeline connecting the outlet of the centrifuge 3 to the storage tank 4 opens, and the steam enters the storage tank 4.

[0070] 4. A sterilization breathing valve 300, a pneumatic valve and a temperature sensor are installed at the top of the storage tank 4. After the steam temperature and pressure in the storage tank 4 reach the set threshold or the set time, the pneumatic ball valve on the feed pipe at the bottom of the storage tank 4 is opened, and the high-temperature steam enters the concentrate pump 9 and the single-effect or double-effect thin film concentrator 5 in reverse.

[0071] 5. Once the temperature and pressure in the concentrator 5 reach the set threshold, the pneumatic ball valve of the pipeline connecting the concentrator 5 to the receiving chamber 7 or the receiving tank 6 will be automatically opened. At the same time, the valve at the end of the receiving chamber 7 or the pneumatic ball valve at the end of the receiving tank 6 will be opened, so that all pipelines are in a steam flow state and the reverse steam flow will be used for sterilization for 10 to 30 minutes.

[0072] 6. After the set time is reached, the controller 10 will sequentially close the valves of the steam flow pipeline, and open the sterilization breathing valve 300 and the pneumatic valve 200. After the pressure in the tank and pipeline returns to normal, the pneumatic valve 200 will close, and the steam sterilization process will end.

[0073] According to the microbial limit standards for non-sterile veterinary drug preparations in the 2020 edition of the Pharmacopoeia of Veterinary Medicine, as shown in Table 1.

[0074] Table 1

[0075]

[0076] Qingwen Jiedu oral liquid was prepared using the process of this invention: prepared according to the 2020 edition of the Veterinary Pharmacopoeia, 500L / batch. Microbiological testing was performed on the oral liquid prepared using the method of this invention, and the results are shown in Table 2.

[0077] Table 2

[0078] Test results Detection value: cfu / ml Candida albicans 0 yeast 1 mold 1 Bacillus 0 E. coli 0 salmonella 0

[0079] Mulberry Seed Lung-Clearing Oral Liquid was prepared using the process of this invention: prepared according to the 2020 edition of the Veterinary Pharmacopoeia, 500L / batch. Microbiological testing was performed on the oral liquid prepared using the method of this invention, and the results are shown in Table 3.

[0080] Table 3

[0081]

[0082]

[0083] Based on the test data in Tables 2 and 3, it can be concluded that, using the process of the present invention, the aerobic Bacillus spp. in the final oral liquid is completely eliminated, while mold and yeast are effectively controlled below the standard, effectively avoiding the problems of bloating and mold growth in the oral liquid.

[0084] Cost comparison:

[0085] Compared with existing extraction and preparation processes for traditional Chinese veterinary medicines, the cost savings are analyzed as follows:

[0086] 1) Packaging bottles (standard 250ml / bottle):

[0087] The existing preparation process requires the use of high-temperature resistant PE bottles: cost 1.5 yuan.

[0088] The preparation process of this application uses ordinary polyethylene bottles: cost 0.5 yuan.

[0089] 2) This application saves labor and energy costs (based on 1000L): It eliminates the terminal sterilization process, saving 100 kWh of electricity, approximately 80 yuan; and saves labor costs of approximately 100 yuan.

[0090] 3) Simplified process:

[0091] This application eliminates the need for sterilization equipment and cleanrooms after oral liquid filling: 300,000 to 1,000,000 yuan.

[0092] In summary, excluding fixed costs such as equipment and workshops, each 1000L of oral liquid can save approximately 4180 yuan in direct costs, demonstrating significant economic value.

Claims

1. An automated sterilization process for the entire pipeline of traditional Chinese veterinary medicine extraction, characterized in that: Pneumatic control valves (100) are installed at the inlet and outlet of the tank in the entire pipeline. Pressure balance pipelines connected to the outside are installed on the tank in the entire pipeline. Pneumatic valves (200) and sterilization breathing valves (300) are installed on the pressure balance pipelines. The sterilization breathing valves (300) are located at the outlet of the pressure balance pipelines. Temperature sensors and pressure sensors are installed on the tank in the entire pipeline. A controller (10) is also included. The controller (10) is connected to the temperature sensor, pressure sensor, pneumatic valve (200) and pneumatic control valve (100) respectively. The fully automated pipeline sterilization process includes the following steps: S1. Before the preparation of the traditional Chinese veterinary medicine, the controller (10) controls the steam system to sterilize the entire pipeline with high temperature and high pressure from one side of the extraction tank (1) according to the preparation process. The high temperature and high pressure steam temperature is above 120°C and the pressure is above 2 atmospheres. The sterilization steps are as follows: close the pneumatic valves (200) on each tank, open the pneumatic control valve (100) at the inlet of the first tank, and when the controller (10) reaches the set threshold according to the temperature and pressure in the first tank, open the pneumatic control valve (100) at the outlet of the first tank, and perform the same threshold judgment and sequential sterilization on the subsequent pipelines and tanks in sequence. After the high temperature and high pressure sterilization is completed, close the pneumatic control valves (100) corresponding to the inlet and outlet of each tank in the opposite direction of the steam flow, and open the pneumatic valves (200) on each tank. After the pressure in each tank reaches the normal pressure, close the pneumatic valves (200) to complete the sterilization. S2. After sterilization, the traditional Chinese veterinary medicine is heated and extracted in the extraction tank (1). The extraction temperature ensures that the extract meets the sterility requirements. After extraction, subsequent separation and concentration are carried out to finally obtain a cooled oral liquid. S3. The cooled oral liquid is sent to the aseptic filling workshop through a sterile pipeline for aseptic filling. Aseptic filling is carried out using non-heat-resistant packaging.

2. The fully automated pipeline sterilization process for extracting traditional Chinese veterinary medicine according to claim 1, characterized in that: In step S3, non-heat-resistant packaging undergoes aseptic treatment before entering the aseptic filling workshop.

3. The fully automated sterilization process for the extraction of traditional Chinese veterinary medicines according to claim 2, characterized in that: In step S3, the aseptic treatment of non-heat-resistant packaging is carried out by fumigation. A fumigation workshop connected to the aseptic filling workshop is set up. After aseptic treatment in the fumigation workshop, the non-heat-resistant packaging is directly sent to the aseptic filling workshop.

4. The fully automated pipeline sterilization process for extracting traditional Chinese veterinary medicine according to claim 1, characterized in that: The entire pipeline for extracting traditional Chinese veterinary medicine includes an extraction tank (1), a filter (2), a centrifuge (3), a storage tank (4), and a concentrator, which are connected in sequence by pipelines. (5), the concentrator (5) is connected to the receiving tank (6) or the aseptic receiving room (7) through a pipeline, the receiving tank (6) or the aseptic receiving room (7) is connected to the aseptic filling workshop through a pipeline, and the concentrator (5) is a vacuum concentrator; The inlet of the extraction tank (1) is connected to the steam system. The inlet and outlet of the extraction tank (1), the liquid storage tank (4), the concentrator (5), the paste collection tank (6) and the sterile paste collection room (7) are all equipped with pneumatic control valves (100). The extraction tank (1), the liquid storage tank (4), the concentrator (5), and the paste collection tank (6) are all equipped with pressure balance pipelines that communicate with the outside. The pressure balance pipelines are equipped with pneumatic valves (200) and sterile breathing valves (300). The extraction tank (1), the liquid storage tank (4), the concentrator (5), and the paste collection tank (6) are all equipped with temperature sensors and pressure sensors. A circulation pump (8) is provided between the filter (2) and the centrifuge (3), and a concentrate pump (9) is provided on the pipeline between the concentrator (5) and the paste collection tank (6) or the aseptic paste collection room (7).

5. The fully automated pipeline sterilization process for extracting traditional Chinese veterinary medicine according to claim 4, characterized in that: Both the pneumatic control valve (100) and the pneumatic valve (200) are connected to the compressed gas pipeline; The controller (10) is used to control the opening and closing of the pneumatic valve (200) and the pneumatic control valve (100).

6. The fully automated pipeline sterilization process for extracting traditional Chinese veterinary medicine according to claim 4, characterized in that: Each of the extraction tank (1), liquid storage tank (4), concentrator (5), and paste collection tank (6) is equipped with a pressure check valve.

7. The fully automated pipeline sterilization process for extracting traditional Chinese veterinary medicine according to claim 1, characterized in that: The steam system includes a steam generator or a high-pressure boiler.

8. The fully automated pipeline sterilization process for extracting traditional Chinese veterinary medicine according to claim 3, characterized in that: The fumigation workshop includes a fumigation room (11) connected to the aseptic filling workshop, an ultrasonic atomizer (12), a circulating fan (13) and a temperature control module installed in the fumigation room (11); The fumigation chamber (11) is equipped with an air inlet pipe (1101) and an air outlet pipe (1102). The air inlet pipe (1101) is equipped with a sterilization filter (14), and the air outlet pipe (1102) is equipped with an exhaust fan (15) and a one-way air outlet valve (16). The fumigation room (11) is provided with a material inlet sealing door (17) on the side away from the aseptic filling workshop, and the fumigation room (11) is provided with a material outlet sealing door (18) on the side adjacent to the aseptic filling workshop, which is connected to the clean area of ​​the filling workshop. The temperature control module is used to control the temperature of the fumigation room (11).

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