Magnetic particle separation device

Abstract

The present application proposes a magnetic particle separation device, comprising: a magnet fixing part, which is cylindrical and provided with a plurality of magnet mounting grooves; and a plurality of magnets, which are mounted in the plurality of magnet mounting grooves, and the plurality of magnets are arranged along the circumference of the magnet fixing part to form a magnet ring, and the magnet ring forms a uniformly changing magnetic field which gradually increases from the center to the surroundings on its radial inner side, and the magnet ring comprises a radial magnetization magnet group and a circumferential magnetization magnet group, and the magnetization direction of the plurality of magnets in the radial magnetization magnet group is radial, and the magnetization direction of the plurality of magnets in the circumferential magnetization magnet group is a tangential direction of the circumferential direction corresponding to the position of the magnet in the magnet ring, and the radial magnetization magnet group and the circumferential magnetization magnet group are arranged alternately, and each group of radial magnetization magnet groups and each group of circumferential magnetization magnet groups include a plurality of magnets, and the radial size of at least some of the magnets in the radial magnetization magnet group is smaller than the radial size of the magnets in the circumferential magnetization magnet group.

Description

Technical Field

[0001] The present application belongs to the field of biophysical therapy diagnosis technology, and in particular relates to a magnetic particle separation device. Background Art

[0002] In the field of biomedical diagnosis, magnetic particle separation devices can be used to separate magnetic particles from other components in a sample.

[0003] Chinese patent CN101208153B discloses a device and method for separating magnetic particles, which forms a non-uniform magnetic field through a magnet, but has the following disadvantages.

[0004] Parts with the same radial position in the working area have different magnetic field strengths at different locations in the circumferential direction, which affects the separation effect. Summary of the invention

[0005] The present application aims to provide a magnetic particle separation device.

[0006] The embodiment of the present application provides a magnetic particle separation device, comprising:

[0007] A magnet fixing member, wherein the magnet fixing member is cylindrical and is provided with a plurality of magnet mounting grooves; and

[0008] A plurality of magnets are installed in the plurality of magnet installation grooves, the plurality of magnets are arranged along the circumference of the magnet fixing member to form a magnet ring, the radial inner side of the magnet ring is used to place the container, and the magnet ring forms a uniform changing magnetic field on its radial inner side that gradually increases from the center to the surroundings,

[0009] The magnet ring comprises a radial magnetization magnet group and a circumferential magnetization magnet group. The magnetization direction of the plurality of magnets in the radial magnetization magnet group is radial, and the magnetization direction of the plurality of magnets in the circumferential magnetization magnet group is a tangential direction of the circumference corresponding to the position of the magnet in the magnet ring. The radial magnetization magnet group and the circumferential magnetization magnet group are arranged alternately.

[0010] Each of the radially magnetized magnet groups and each of the circumferentially magnetized magnet groups includes a plurality of magnets, and radial dimensions of at least some of the magnets in the radially magnetized magnet group are smaller than radial dimensions of the magnets in the circumferentially magnetized magnet group.

[0011] In at least one possible implementation, the radial size of the magnets located at the edge of each radial magnetization magnet group and adjacent to the circumferential magnetization magnet group is smaller than the radial size of the magnets in the circumferential magnetization magnet group.

[0012] In at least one possible implementation, in each group of the radially magnetized magnet groups, the radially inner ends of the magnets located at the edge and adjacent to the circumferentially magnetized magnet group are located radially outward of the radially inner ends of the remaining magnets.

[0013] In at least one possible implementation, the radial size of the magnets in each radial magnetization magnet group that are located in the middle and not adjacent to the circumferential magnetization magnet group is smaller than the radial size of the magnets in the circumferential magnetization magnet group.

[0014] In at least one possible implementation, in each group of the radially magnetized magnet groups, the radially outer end of the magnet that is located in the middle and not adjacent to the circumferentially magnetized magnet group is located radially inward of the radially outer ends of the remaining magnets.

[0015] In at least one possible implementation, the magnets of the radial magnetization magnet group have the same size, the magnets of the circumferential magnetization magnet group have the same size, and the radial size of each magnet of the circumferential magnetization magnet group is larger than the radial size of each magnet of the radial magnetization magnet group.

[0016] In at least one possible implementation, the radial magnetization magnet group includes a first radial magnetization magnet group, a second radial magnetization magnet group, a third radial magnetization magnet group, and a fourth radial magnetization magnet group.

[0017] The circumferential magnetization magnet group includes a first circumferential magnetization magnet group, a second circumferential magnetization magnet group, a third circumferential magnetization magnet group and a fourth circumferential magnetization magnet group.

[0018] In the clockwise direction, the first radial magnetization magnet group, the first circumferential magnetization magnet group, the second radial magnetization magnet group, the second circumferential magnetization magnet group, the third radial magnetization magnet group, the third circumferential magnetization magnet group, the fourth radial magnetization magnet group and the fourth circumferential magnetization magnet group are arranged in sequence to form a magnet ring.

[0019] The internal magnetic flux lines of the first radial magnetization magnet group and the third radial magnetization magnet group point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group and the fourth radial magnetization magnet group point radially outward,

[0020] The internal magnetic flux lines of the first circumferential magnetization magnet group and the fourth circumferential magnetization magnet group point to the first radial magnetization magnet group, and the internal magnetic flux lines of the second circumferential magnetization magnet group and the third circumferential magnetization magnet group point to the third radial magnetization magnet group.

[0021] In at least one possible implementation, the number of magnetic pole pairs of the magnet ring is 4.

[0022] Each of the radial magnetization magnet groups includes a plurality of magnets of the same number, and each of the circumferential magnetization magnet groups includes a plurality of magnets of the same number,

[0023] The radial magnetization magnet group and the circumferential magnetization magnet group may have the same or different numbers of magnets.

[0024] In at least one possible embodiment, the magnetic particle separation device also includes a sleeve, which is located radially inside the magnet, and the peripheral wall of the magnet fixing is provided with a plurality of threaded holes penetrating the peripheral wall, and the threaded holes are aligned with the bottom of the magnet mounting groove. The fasteners are screwed into the threaded holes to press the magnet radially inward, so that the radial inner side of the magnet abuts against the outer peripheral surface of the sleeve, so that the magnet is radially positioned in the magnet mounting groove.

[0025] In at least one possible implementation, the magnetic particle separation device further includes a shielding cover, and the shielding cover is sleeved on the outside of the magnet ring.

[0026] By adopting the above technical solution, the magnetic particle separation device of the present application can make the magnetic field strength at the parts with the same radial position in the working area consistent at various locations in the circumferential direction, so that the separation effect of the magnetic particles is better. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 A schematic structural diagram of a magnetic particle separation device according to an embodiment of the present application is shown.

[0028] Figure 2 A cross-sectional view of a magnetic particle separation device according to an embodiment of the present application is shown.

[0029] Figure 3 A schematic structural diagram of a magnetic particle separation device (without showing the upper cover) according to an embodiment of the present application is shown.

[0030] Figure 4 A schematic diagram of the internal structure of a magnetic particle separation device according to an embodiment of the present application is shown.

[0031] Figure 5 A schematic structural diagram of a magnet fixing device for separating magnetic particles according to an embodiment of the present application is shown.

[0032] Figure 6 A schematic structural diagram of a magnet ring of a magnetic particle separation device according to an embodiment of the present application is shown.

[0033] Figure 7 The figure shows a curve of magnetic field variation along the X-axis or Y-axis direction in the working area of ​​the magnetic particle separation device according to the embodiment of the present application.

[0034] Figure 8 The figure shows a curve of magnetic field variation in the working area of ​​the magnetic particle separation device according to an embodiment of the present application along a direction with an angle of 45 degrees with both the X-axis and the Y-axis.

[0035] Description of Reference Numerals

[0036] 1 Magnet

[0037] 11 radial magnetization magnet group 111 first radial magnetization magnet group 112 second radial magnetization magnet group 113 third radial magnetization magnet group 114 fourth radial magnetization magnet group

[0038] 12 Circumferential magnetization magnet group 121 First circumferential magnetization magnet group 122 Second circumferential magnetization magnet group 123 Third circumferential magnetization magnet group 124 Fourth circumferential magnetization magnet group

[0039] 2 magnet fixing piece 21 magnet mounting groove 22 threaded hole

[0040] 3 shielding cover 31 shielding cover peripheral wall 32 shielding cover top wall

[0041] 4 end cover 41 upper end cover 42 lower end cover

[0042] 5 sleeve

[0043] 6 housing 61 housing peripheral wall 62 housing bottom wall

[0044] 7 Upper cover

[0045] 8 Base

[0046] A axial direction C circumferential direction DETAILED DESCRIPTION

[0047] In order to more clearly explain the above-mentioned purposes, features and advantages of the present application, the specific implementation methods of the present application are described in detail in this section in conjunction with the accompanying drawings. In addition to the various implementation methods described in this section, the present application can also be implemented in other different ways. Without violating the spirit of the present application, those skilled in the art can make corresponding improvements, deformations and substitutions, so the present application is not limited by the specific embodiments disclosed in this section. The scope of protection of the present application shall be subject to the claims.

[0048] like Figures 1 to 8 As shown, an embodiment of the present application proposes a magnetic particle separation device, which includes a plurality of magnets 1, a magnet fixing member 2, a shielding cover 3, an end cover 4, a sleeve 5, a shell 6, an upper cover 7 and a base 8.

[0049] like Figures 2 to 5As shown, the magnet fixing part 2 may be cylindrical, and the magnet fixing part 2 is provided with a magnet mounting groove 21, and the magnet mounting groove 21 may be provided at the inner circumference of the magnet fixing part 2, and the magnet mounting groove 21 forms an opening at the inner circumference of the magnet fixing part 2. A plurality of magnet mounting grooves 21 may be provided along the circumferential direction C of the magnet fixing part 2.

[0050] A plurality of magnets 1 can be embedded in the magnet mounting groove 21, and the plurality of magnets 1 are arranged along the circumferential direction C of the magnet fixing member 2 to form a magnet ring. A uniformly changing magnetic field can be formed on the radial inner side of the magnet ring, and the plurality of magnets 1 are arranged in a Halbach array, so that the magnet ring forms a uniformly changing magnetic field on its radial inner side that gradually increases from the center to the surroundings.

[0051] Figure 6 The one-way arrow in the figure indicates the magnetization direction of the magnet 1 (the direction of the internal magnetic flux lines), and the magnetic flux lines point from the S pole to the N pole inside the magnet.

[0052] like Figure 6 As shown, the number of magnetic pole pairs P of the magnet ring may be an integer greater than or equal to 2. In this embodiment, the number of magnetic pole pairs P of the magnet ring may be 4. The magnet ring has 8 groups of magnets 1 in total.

[0053] Optionally, in other possible implementations, the number P of magnetic pole pairs of the magnet ring may also be 8.

[0054] The magnet ring includes a radial magnetization magnet group 11 and a circumferential magnetization magnet group 12. The radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 are alternately arranged to form a strong uniformly changing magnetic field.

[0055] The magnetization directions of the multiple magnets in the radial magnetization magnet group 11 are substantially the same, but not completely the same, and the magnetization direction of each magnet 1 in the radial magnetization magnet group 11 is radial. The magnetization directions of the multiple magnets in the circumferential magnetization magnet group 12 are substantially the same, but not completely the same, and the magnetization direction of each magnet 1 in the circumferential magnetization magnet group 12 is the circumferential direction (or the tangential direction of the circumferential direction) of the position of the magnet in the magnet ring.

[0056] The radial magnetization magnet group 11 includes a first radial magnetization magnet group 111 , a second radial magnetization magnet group 112 , a third radial magnetization magnet group 113 and a fourth radial magnetization magnet group 114 .

[0057] The circumferentially magnetized magnet group 12 includes a first circumferentially magnetized magnet group 121 , a second circumferentially magnetized magnet group 122 , a third circumferentially magnetized magnet group 123 and a fourth circumferentially magnetized magnet group 124 .

[0058] In the clockwise direction, the first radial magnetization magnet group 111, the first circumferential magnetization magnet group 121, the second radial magnetization magnet group 112, the second circumferential magnetization magnet group 122, the third radial magnetization magnet group 113, the third circumferential magnetization magnet group 123, the fourth radial magnetization magnet group 114 and the fourth circumferential magnetization magnet group 124 are arranged in sequence to form a magnet ring.

[0059] In this embodiment, the internal magnetic flux lines of the first radial magnetization magnet group 111 and the third radial magnetization magnet group 113 point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group 112 and the fourth radial magnetization magnet group 114 point radially outward. The internal magnetic flux lines of the first circumferential magnetization magnet group 121 and the fourth circumferential magnetization magnet group 124 point to the first radial magnetization magnet group 111, and the internal magnetic flux lines of the second circumferential magnetization magnet group 122 and the third circumferential magnetization magnet group 123 point to the third radial magnetization magnet group 113.

[0060] Each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 includes multiple magnets. The multiple magnets can make the magnetization direction of each part of the radial magnetization magnet group 11 as radial as possible, and the multiple magnets can make the overall magnetization direction of the circumferential magnetization magnet group 12 as close to an arc as possible rather than a straight line.

[0061] The width of the magnet 1 along the radial direction may be greater than the thickness along the circumferential direction C. For example, the width of the magnet 1 may be greater than or equal to 1.5 times the thickness and less than 5 times the thickness. The greater the width of the magnet 1 along the radial direction, the higher the magnetic field strength formed, and the smaller the thickness of the magnet 1 along the circumferential direction C, the better the uniformity of the magnetic field formed along the circumferential direction C. The ratio of the width and thickness of the magnet can be adjusted according to specific design requirements.

[0062] The number of magnets in each radial magnetization magnet group 11 and the number of magnets in each circumferential magnetization magnet group 12 may be the same, for example, the number of magnets in each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 is 5. That is, the magnetic particle separation device may have 8 groups, each with 5 magnets 1, for a total of 40 magnets 1.

[0063] The magnet ring formed by the above magnet arrangement only needs one circle to obtain sufficient magnetic field strength, so that the magnetic field of the magnetic particle separation device is easy to set, the number of magnets used is small, and the cost is low.

[0064] It can be understood that in other possible embodiments, the number of magnets in the radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 may be different. For example, each radial magnetization magnet group 11 may include 5 magnets, and each circumferential magnetization magnet group 12 may include 4 magnets, so the magnetic particle separation device may have 36 magnets 1. Of course, each radial magnetization magnet group 11 may include 4 magnets, and each circumferential magnetization magnet group 12 may include 5 magnets.

[0065] like Figures 2 to 4 As shown, the end caps 4 are mounted at both axial ends of the magnet fixture 2, and the end caps 4 include an upper end cap 41 and a lower end cap 42. The upper end cap 41 can be connected to the upper end of the magnet fixture 2 by a fastener such as a bolt, and the lower end cap 42 can be connected to the lower end of the magnet fixture 2 by a fastener such as a bolt. The lower end cap 42 can be used to place a container, and the container is located radially inside the sleeve 5. The space for placing the container can be called a working area, and the sample to be separated can be placed in the container.

[0066] The sleeve 5 can be cylindrical and can be arranged in the hollow area of ​​the magnet fixing part 2. The axial ends of the sleeve 5 can be connected to the end covers 4, the upper end of the sleeve 5 can be connected to the upper end cover 41, and the lower end of the sleeve 5 can be connected to the lower end cover 42.

[0067] The sleeve 5 is located radially inside the magnet 1, and the peripheral wall of the magnet fixing member 2 may be provided with a plurality of threaded holes 22, which penetrate the peripheral wall of the sleeve 5, and the threaded holes 22 may be aligned with the bottom (i.e., the radially outer portion) of the magnet mounting groove 21. For the same magnet mounting groove 21, a plurality of threaded holes 22 may be provided along the axial direction of the sleeve 5. By screwing a fastener such as a stud into the threaded hole 22 to press the magnet 1 radially inward, the radial inner portion of the magnet 1 may be brought into contact with the outer peripheral surface of the sleeve 5, so that the magnet 1 is radially positioned in the magnet mounting groove 21 and will not fall out.

[0068] The upper cover 7 can be connected to the upper end cover 41. The outer periphery of the upper cover 7 can be provided with a handle protruding radially outward. The handle can be provided with a groove or a hollow to facilitate fingers to extend into the groove or the hollow to hook the handle, thereby facilitating the movement of the magnetic particle separation device.

[0069] A light source such as an LED light strip may be provided on the inner periphery of the sleeve 5. Optionally, the light source is located at the lower end of the sleeve 5, and the working area can be illuminated by the light source, so as to facilitate observation of the liquid sample (such as blood) in the container.

[0070] like Figures 2 to 4As shown, the shielding cover 3 is sleeved on the outside of the magnet ring, and the shielding cover 3 may include a shielding cover peripheral wall 31 and a shielding cover top wall 32. The shielding cover peripheral wall 31 may be sleeved on the outer periphery of the magnet fixing part 2, and the shielding cover top wall 32 may be connected to the upper end cover 41. The shielding cover top wall 32 is located above the magnet ring.

[0071] The shielding cover 3 can be made of ferromagnetic materials such as iron. The shielding cover 3 can prevent the magnetic field from escaping from the upper side and surrounding sides of the magnetic particle separation device and affecting the space outside the working area of ​​the magnetic particle separation device. For example, the shielding cover can prevent the operator and his / her watches, mobile phones, etc. from being affected by the magnetic field of the magnetic particle separation device.

[0072] It is understood that in other possible implementations, the shielding cover 3 may further include a shielding cover bottom wall (not shown in the figure), which may be connected to the lower end cover and may shield the magnetic field from escaping downward from the working area.

[0073] The base 8 can be connected to the lower end cover 42, and the base 8 can be provided with a battery compartment and a control board. The battery compartment can accommodate batteries, and the batteries can power the light source. The battery compartment can be provided with a pole piece, and the positive and negative poles of the battery installed in the battery compartment can contact the pole piece, and the light source and the pole piece can be electrically connected to the control board. The control board can be connected to the switch button through a cable, and the upper cover 7 can be provided with a switch mounting hole, and the switch button can be installed in the switch mounting hole. The light source can be turned on or off by operating the switch button.

[0074] like Figure 2 As shown, the shell 6 may include a shell peripheral wall 61 and a shell bottom wall 62 . The shell peripheral wall 61 may be disposed on the outer periphery of the shielding cover peripheral wall 31 , and the shell bottom wall 62 may be disposed below the base 8 .

[0075] like Figure 6 As shown, the radial dimensions of at least some of the magnets 1 of the radially magnetized magnet group 11 may be smaller than the radial dimensions of the magnets 1 of the circumferentially magnetized magnet group 12, so that the magnetic field strengths of parts with the same radial position in the working area at various locations in the circumferential direction may be substantially the same.

[0076] In the illustrated example, the magnets of the circumferential magnetization magnet group 12 can have the same size, and the magnets of the radial magnetization magnet group 11 can have the same size. The radial size of each magnet of the radial magnetization magnet group 11 is smaller than the radial size of each magnet of the circumferential magnetization magnet group 12. In each radial magnetization magnet group 11, the magnet 1 located at the edge and adjacent to the circumferential magnetization magnet group 12 is arranged radially outward compared to the magnet 1 located in the middle and not adjacent to the circumferential magnetization magnet group 12. In this way, by reducing the types of magnets of different specifications (two types in this example), the number of components can be reduced, the assembly process can be simplified, and the cost can be reduced.

[0077] In other possible implementations, the magnets of the circumferential magnetization magnet group 12 may have different sizes, and / or the magnets of the radial magnetization magnet group 11 may have different sizes. In particular, the magnets of the radial magnetization magnet group 11 may have different sizes.

[0078] exist Figure 7 and Figure 8 In the figure, the horizontal axis represents the coordinate position of the working area (in millimeters), and the vertical axis represents the magnetic field strength (in Tesla).

[0079] like Figure 7 As shown, in the X-axis direction and the Y-axis direction, from one end to the other end of the working area, the magnetic field strength gradually weakens and then gradually increases, and there is no sudden change. The magnetic field strength at the center of the working area is close to 0.

[0080] like Figure 8 As shown, in the direction where the angles with the X-axis and the Y-axis are both 45 degrees, from one end to the other end of the working area, the magnetic field strength gradually weakens and then gradually increases, and there is no sudden change. The magnetic field strength at the center of the working area is close to 0.

[0081] Reference Figure 7 and Figure 8 The curves of magnetic field intensity changing with position along the X-axis direction, along the Y-axis direction, and along the direction with an angle of 45 degrees with the X-axis and the Y-axis are basically the same. It can be considered that the magnetic field intensity at various locations in the circumferential direction of the parts with the same radial position in the working area is consistent, which makes the separation effect of magnetic particles better.

[0082] Specifically, the radial size of the magnet 1 located at the edge position and adjacent to the circumferential magnet group 12 in each radial magnetization magnet group 11 may be smaller than the radial size of the magnet 1 in the circumferential magnetization magnet group 12. It can be understood that the magnet 1 with a smaller radial size located at the edge position in each radial magnetization magnet group 11 may be a magnet at the most edge position or multiple magnets close to the edge position. For example, it may be two or four magnets located at the two end edges respectively among the five magnets, or it may be two or four magnets located at the two end edges respectively among the six magnets.

[0083] The radially inner end of the magnet 1 located at the edge and adjacent to the circumferentially magnetized magnet group 12 in each radially magnetized magnet group 11 may be located radially outward of the radially inner ends of the remaining magnets 1 .

[0084] It can be understood that the magnets 1 located at the edge of each radial magnetization magnet group 11 and adjacent to the circumferential magnetization magnet group 12 can be provided with pads on the radial inner side, and the magnets 1 can be abutted against the outer wall surface of the sleeve 5 through the pads. The pads can be made of aluminum or aluminum alloy.

[0085] The radial dimension of the magnet 1 located in the middle position of each radial magnetization magnet group 11 and not adjacent to the circumferential magnetization magnet group 12 may be smaller than the radial dimension of the magnet 1 of the circumferential magnetization magnet group 12. The multiple magnets 1 in a radial magnetization magnet group 11 may be symmetrical along the center line of the radial magnetization magnet group 11. It can be understood that the magnet 1 with a smaller radial dimension located in the middle position of each radial magnetization magnet group 11 may be a magnet in the middle position or multiple magnets relative to the middle position. For example, it may be one magnet or three magnets located in the middle of five magnets, or it may be two magnets or four magnets located in the middle of six magnets.

[0086] The radially outer end of the magnet 1 located in the middle position of each radially magnetized magnet group 11 and not adjacent to the circumferentially magnetized magnet group 12 may be located radially inward of the radially outer ends of the remaining magnets 1 .

[0087] It can be understood that the magnets 1 with smaller radial dimensions that are located in the middle of each radial magnetization magnet group 11 and are not adjacent to the circumferential magnetization magnet group 12 can be squeezed with longer fasteners such as studs. Alternatively, the size of the magnet mounting slots 21 that accommodate these magnets 1 with smaller radial dimensions can be correspondingly smaller than the depth of the remaining magnet mounting slots 21.

[0088] like Figure 6 As shown, the cross section of the magnet can be rectangular, and the manufacturing cost of the magnet with a rectangular cross section is low. In other possible implementations, the cross section of the magnet can also be fan-shaped or trapezoidal.

[0089] The magnetic particle separation device of the present application can achieve the following beneficial effects.

[0090] (1) The magnetic field strength at the same radial position in the working area is consistent at all locations in the circumferential direction, resulting in a better separation effect for magnetic particles.

[0091] (2) The shielding cover can prevent magnetic field leakage, so that the operator and the equipment he carries with him are not affected by the magnetic field.

[0092] (3) Sufficient magnetic field strength can be obtained by a circle of magnets, making it easy to set the magnetic field of the magnetic particle separation device, using fewer magnets and lowering the cost.

[0093] (4) The radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 are simply arranged and easily assembled.

[0094] It should be understood that at least some aspects or features of the above-mentioned implementation modes, embodiments or examples may be appropriately combined.

[0095] It is understood that in the present application, when the number of parts or components is not particularly limited, the number may be one or more, and the multiple here means two or more. For the case where the number of parts or components shown in the drawings and / or described in the specification is a specific number such as two, three, four, etc., the specific number is usually exemplary and not restrictive, and it can be understood as multiple, that is, two or more, but this does not mean that the present application excludes the case of one.

[0096] In the present application, unless otherwise clearly stated or limited, the terms such as "install", "assemble", "assemble", "connect", "connect", "couple", "link", "abut", "connect", "interconnect", "intercommunication", "conduction", "fixation", "fastening" and the like should be understood in a broad sense, for example, they can be direct or indirect. For example, regarding connection, it can be a fixed connection, a detachable connection, or an integral one; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly stated or limited. For example, regarding connectivity / conduction, it can be direct connectivity / conduction, or it can be indirect connectivity / conduction via an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0097] In the present application, unless otherwise clearly stated or limited, a component disposed on / installed on / located on / accommodated on / placed in, within, inside, etc. another component may be any of the following two situations: a part or most of the one component is located in the other component; and the one component is completely accommodated in the other component.

[0098] Although the present application is described in detail using the above-mentioned embodiments, it is obvious to those skilled in the art that the present application is not limited to the embodiments described in this specification. The present application can be modified and implemented as a modified embodiment without departing from the subject matter and scope of the present application as determined by the claims. Therefore, the description in this specification is for the purpose of illustration and does not have any restrictive meaning for the present application.

Claims

1. A magnetic particle separation device, characterized in that: include: A magnet fixing member (2), the magnet fixing member (2) being cylindrical and provided with a plurality of magnet mounting grooves (21); as well as A plurality of magnets (1), the plurality of magnets (1) being mounted in the plurality of magnet mounting grooves (21), the plurality of magnets (1) being arranged along the circumferential direction (C) of the magnet fixing member (2) to form a magnet ring, the radial inner side of the magnet ring being used to place a container, the magnet ring forming a uniformly changing magnetic field on its radial inner side that gradually increases from the center to the periphery, The magnet ring comprises a radial magnetization magnet group (11) and a circumferential magnetization magnet group (12); the magnetization direction of the plurality of magnets (1) of the radial magnetization magnet group (11) is radial, and the magnetization direction of the plurality of magnets (1) of the circumferential magnetization magnet group (12) is a tangential direction of the circumference corresponding to the position of the magnet in the magnet ring; the radial magnetization magnet group (11) and the circumferential magnetization magnet group (12) are arranged alternately. Each group of the radially magnetized magnet groups (11) and each group of the circumferentially magnetized magnet groups (12) comprises a plurality of the magnets (1), and the radial dimensions of at least some of the magnets (1) in the radially magnetized magnet group (11) are smaller than the radial dimensions of the magnets (1) in the circumferentially magnetized magnet group (12).

2. The magnetic particle separation device according to claim 1, characterized in that: The radial dimensions of the magnets (1) located at the edge of each radial magnetization magnet group (11) and adjacent to the circumferential magnetization magnet group (12) are smaller than the radial dimensions of the magnets (1) of the circumferential magnetization magnet group (12).

3. The magnetic particle separation device according to claim 2, characterized in that: The radial inner end of the magnet (1) located at the edge of each radial magnetization magnet group (11) and adjacent to the circumferential magnetization magnet group (12) is located radially outside the radial inner end of the remaining magnets (1).

4. The magnetic particle separation device according to claim 1, characterized in that: The radial size of the magnet (1) located in the middle position of each group of radially magnetized magnet groups (11) and not adjacent to the circumferentially magnetized magnet group (12) is smaller than the radial size of the magnet (1) of the circumferentially magnetized magnet group (12).

5. The magnetic particle separation device according to claim 4, characterized in that: The radially outer end of the magnet (1) located in the middle position of each radially magnetized magnet group (11) and not adjacent to the circumferentially magnetized magnet group (12) is located radially inward of the radially outer ends of the remaining magnets (1).

6. The magnetic particle separation device according to claim 1, characterized in that: The sizes of the magnets in the radial magnetization magnet group (11) are the same, the sizes of the magnets in the circumferential magnetization magnet group (12) are the same, and the radial size of the magnets in the circumferential magnetization magnet group (12) is greater than the radial size of the magnets in the radial magnetization magnet group (11).

7. The magnetic particle separation device according to claim 1, characterized in that: The radial magnetization magnet group (11) comprises a first radial magnetization magnet group (111), a second radial magnetization magnet group (112), a third radial magnetization magnet group (113) and a fourth radial magnetization magnet group (114). The circumferentially magnetized magnet group (12) comprises a first circumferentially magnetized magnet group (121), a second circumferentially magnetized magnet group (122), a third circumferentially magnetized magnet group (123) and a fourth circumferentially magnetized magnet group (124). In a clockwise direction, the first radial magnetization magnet group (111), the first circumferential magnetization magnet group (121), the second radial magnetization magnet group (112), the second circumferential magnetization magnet group (122), the third radial magnetization magnet group (113), the third circumferential magnetization magnet group (123), the fourth radial magnetization magnet group (114) and the fourth circumferential magnetization magnet group (124) are arranged in sequence to form a magnet ring. The internal magnetic flux lines of the first radial magnetization magnet group (111) and the third radial magnetization magnet group (113) point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group (112) and the fourth radial magnetization magnet group (114) point radially outward. The internal magnetic flux lines of the first circumferential magnetizing magnet group (121) and the fourth circumferential magnetizing magnet group (124) point toward the first radial magnetizing magnet group (111), and the internal magnetic flux lines of the second circumferential magnetizing magnet group (122) and the third circumferential magnetizing magnet group (123) point toward the third radial magnetizing magnet group (113).

8. The magnetic particle separation device according to claim 1, characterized in that: The number of magnetic pole pairs of the magnet ring is 4. Each of the radial magnetization magnet groups (11) includes a plurality of magnets of the same number, and each of the circumferential magnetization magnet groups (12) includes a plurality of magnets of the same number, The number of magnets in the radial magnetization magnet group (11) and the number of magnets in the circumferential magnetization magnet group (12) are the same or different.

9. The magnetic particle separation device according to claim 1, characterized in that: The magnetic particle separation device also includes a sleeve (5), the sleeve (5) is located radially inside the magnet (1), the peripheral wall of the magnet fixing member (2) is provided with a plurality of threaded holes (22) penetrating the peripheral wall, the threaded holes (22) are aligned with the bottom of the magnet mounting groove (21), and the fastener is screwed into the threaded holes (22) to press the magnet (1) radially inward, so that the radial inner side of the magnet (1) abuts against the outer peripheral surface of the sleeve (5), so that the magnet (1) is radially positioned in the magnet mounting groove (21).

10. The magnetic particle separation device according to claim 1, characterized in that: The magnetic particle separation device further comprises a shielding cover (3), wherein the shielding cover (3) is sleeved on the outside of the magnetic ring.

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