A Chinese medicine preparation for eyes and a method for extracting active ingredients thereof

Abstract

The present invention relates to the technical field of preparation of Chinese herbal medicines, and in particular to a method for extracting active ingredients of ophthalmic Chinese herbal medicines. The method comprises the following steps: step S1, raw material processing; step S2, soaking; step S3, heating extraction; and step S4, finished product preparation. The present invention soaks Chinese herbal medicine raw materials so that dry medicinal materials fully absorb solvents, promotes the release of effective ingredients in medicinal materials by heating, automatically and intelligently monitors the soaking process, analyzes the solvent content of medicinal materials, and detects the water absorption capacity of specific medicinal materials in real time to improve the soaking efficiency. At the same time, the quality of medicinal materials is also guaranteed. By detecting the heating extraction process, the inactivation of active ingredients due to excessive temperature is avoided. At the same time, the extraction rate is intelligently calculated, which improves the real-time nature of the detection and the extraction efficiency, so as to ensure that the active substances in the prepared Chinese herbal medicine preparations are effective, thereby alleviating eye fatigue and dry eyes and achieving the effect of preventing and delaying vision growth.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of Chinese herbal medicine preparations, and in particular to an ophthalmic Chinese herbal medicine preparation and a method for extracting active ingredients thereof. Background Art

[0002] Dry eyes, sore eyes, sore eyes, blurred vision and even decreased vision directly affect people's work and life. Eye fatigue is mainly caused by the fact that when people concentrate on watching the screens of electronic products such as TV, computer or mobile phone, the number of times they blink decreases, resulting in a corresponding decrease in tear secretion. At the same time, the flashing screen strongly stimulates the eyes. Therefore, how to improve eye fatigue and dry eyes to avoid myopia or delay vision growth has become a topic of concern. At the same time, in the preparation process of Chinese herbal eye drops, how to ensure the quality and efficiency of drug extraction has become a research direction for relevant researchers.

[0003] Chinese patent publication number: CN111544468B, its technical point is to provide an eye wash for eye care, including Chinese herbal extracts, hydroxypropyl methylcellulose, vitamin E acetate and vitamin B6, which can effectively relieve and prevent the occurrence of dry eyes; however, in the existing preparation technology of Chinese herbal eye drops, there is little disclosure of intelligent monitoring of the soaking and extraction process to avoid long-term soaking of medicinal materials in solvents, which causes inactivation and weakening of the medicinal efficacy of the medicinal materials, and causes the latent microorganisms and molds in the medicinal materials to spread more in the solvent, thereby affecting the safety of the medicine, and the phenomenon that the texture of the medicinal materials becomes soft and the quality is reduced. At the same time, it is difficult to ensure that the medicinal materials absorb the solvent to a saturated state to ensure the extraction effect. Summary of the invention

[0004] To this end, the present invention provides an ophthalmic Chinese medicine preparation and a method for extracting active ingredients thereof, so as to overcome the problem in the prior art that the release quality of the effective ingredients in the medicinal materials is difficult to ensure due to the lack of real-time detection of the medicinal material immersion and extraction process, resulting in low medicinal material extraction efficiency.

[0005] To achieve the above object, the present invention provides an ophthalmic Chinese medicine preparation and a method for extracting active ingredients thereof, comprising:

[0006] Step S1, raw material processing, chopping, weighing and mixing the Chinese herbal raw materials respectively to form a mixed raw material, adding the mixed raw material to the intelligent leaching device, adding the immersion liquid to the intelligent leaching device to form a solid-liquid mixture, and stirring and mixing the solid-liquid mixture;

[0007] Step S2, soaking, sampling and testing the soaking process of the mixed raw material, determining the real-time soaking amount of the mixed raw material and the standard soaking amount range according to the weight of the raw material to be tested before and after squeezing, and when it is determined that the real-time soaking amount is less than the first standard soaking amount, the current soaking time is determined according to the preset time range to determine whether to determine the preset material-liquid ratio, and when it is determined that the real-time soaking amount is greater than the second standard soaking amount, the first preset time is adjusted;

[0008] Step S3, temperature-raising extraction, when it is determined that the real-time infiltration amount is within the standard infiltration amount range, the solid-liquid mixture is subjected to temperature-raising extraction, a real-time solution image of the solution during the extraction process is obtained, and a real-time brightness difference and a real-time extraction rate are calculated according to the real-time solution image. When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time extraction rate is compared with the standard extraction rate, and when it is determined that the real-time extraction rate is greater than or equal to the standard extraction rate and the real-time extraction time is greater than the standard extraction time, the standard extraction time is adjusted, and when it is determined that the real-time brightness difference is less than or equal to the standard brightness difference and the real-time extraction rate is less than the standard extraction rate, the preset extraction temperature is adjusted;

[0009] Step S4, finished product preparation, filtering the solid-liquid mixture, collecting the filtrate and concentrating and drying it to form Chinese herbal medicine powder.

[0010] Furthermore, in the step S2, a standard infiltration amount range is set, the humidity of the mixed raw material is detected and determined at a plurality of sampling points, the raw material to be detected is taken from the solid-liquid mixture to the humidity detection layer for squeezing by a grabbing mechanism, the weight value of the raw material to be detected before squeezing is obtained and recorded as the real-time infiltration amount, and the real-time infiltration amount is compared with the standard infiltration amount range,

[0011] If the real-time infiltration amount is within the standard infiltration amount range, the real-time brightness difference value is compared with the standard brightness difference value to determine whether the extraction state of the mixed raw material is normal;

[0012] If the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively to determine whether to adjust the immersion state.

[0013] Furthermore, in step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively.

[0014] If the real-time infiltration amount is less than the first standard infiltration amount, the current infiltration time of the mixed raw material is obtained, and the current infiltration time is compared with the preset time range to determine whether to adjust the first preset time.

[0015] Furthermore, in step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively.

[0016] If the real-time infiltration amount is greater than the second standard infiltration amount, the current soaking time of the mixed raw material is obtained, and the first preset time is adjusted according to the real-time infiltration amount and the second standard infiltration amount.

[0017] Furthermore, in step S2, a preset material-liquid ratio of the solid-liquid mixture is set, and when it is determined that the real-time infiltration amount of the raw material to be detected is less than the first standard infiltration amount, the current immersion time of the mixed raw material is obtained, and the current immersion time is compared with the preset time range.

[0018] If the current soaking time is longer than the second preset time, the preset material-liquid ratio is adjusted according to the current soaking time and the second preset time;

[0019] Among them, Gc'=Gc×[1+(Ts-Tc2) / Ts], Gc represents the set preset material-liquid ratio, Gc' represents the adjusted preset material-liquid ratio, Ts represents the current soaking time of the mixed raw materials, Tc2 represents the set second preset time, the preset time range is a fixed value, the second preset time is the maximum value of the preset time range, and changes with the first preset time.

[0020] Furthermore, when it is determined that the real-time infiltration amount of the mixed raw material is within the standard infiltration amount range, the solid-liquid mixture is heated, and two real-time solution images corresponding to the two end points of the preset detection time period are obtained by a camera mechanism, and the real-time brightness difference is calculated based on the two real-time solution images, and the real-time brightness difference is compared with the standard brightness difference. When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time extraction rate of the mixed raw material is calculated, and the real-time extraction rate is compared with the standard extraction rate to determine whether to adjust the preset extraction temperature.

[0021] Further, when it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time brightness difference calculated in the previous preset detection period is obtained, and the real-time brightness difference in the current preset detection period is subtracted from the real-time brightness difference in the previous preset detection period and then divided by the preset detection time to obtain the real-time extraction rate of the mixed raw material, and the real-time extraction rate is compared with the standard extraction rate.

[0022] If the real-time extraction rate is greater than or equal to the standard extraction rate, the real-time extraction duration will be judged according to the standard extraction duration to determine whether to adjust the standard extraction duration;

[0023] If the real-time extraction rate is less than the standard extraction rate, the preset extraction temperature is adjusted, and the above-mentioned calculation of the real-time brightness difference and the determination operation of comparing the real-time brightness difference with the standard brightness difference are continued, until it is determined again that the real-time brightness difference is less than or equal to the standard brightness difference, and the real-time extraction rate is less than the standard extraction rate, the extraction process of the mixed raw material is completed;

[0024] Among them, Qs'=Qs×[1+(Vb-Vs) / Vs], Qs represents the set preset extraction temperature, Qs' represents the adjusted preset extraction temperature, Vb represents the set standard extraction rate, and Vs represents the calculated real-time extraction rate.

[0025] Furthermore, in step S3, a standard extraction time of the mixed raw material is set. When it is determined that the real-time extraction rate is greater than or equal to the standard extraction rate, the real-time extraction time corresponding to the current moment is obtained, and the real-time extraction time is determined according to the standard extraction time.

[0026] If the real-time extraction time is longer than the standard extraction time, the standard extraction time will be adjusted;

[0027] Among them, Mb'=Mb×[1+(Vs-Vb) / Vs], Mb represents the set standard extraction time, Mb' represents the adjusted standard extraction time, Vs represents the calculated real-time extraction rate, and Vb represents the set standard extraction rate.

[0028] Further, the weight of the raw material to be tested after the squeezing process is obtained and recorded as the initial raw material weight, and the standard infiltration amount, the first standard infiltration amount, the second standard infiltration amount and the standard infiltration amount range are determined according to the initial raw material weight, the water absorption strength, the current soaking time, the second preset time and the water content difference;

[0029] Among them, Hb=Zs×Pb×Ts / Tc2, Hb1=Hb-ΔS, Hb2=Hb+ΔS, Hb represents the calculated standard infiltration amount, Zs represents the initial raw material weight after the raw material to be tested is squeezed, Pb represents the water absorption strength of the mixed raw material, Ts represents the current soaking time, Tc2 represents the set second preset time, ΔS represents the set moisture content difference, Hb1 represents the calculated first standard infiltration amount, Hb2 represents the calculated second standard infiltration amount, and the first standard infiltration amount and the second standard infiltration amount constitute the standard infiltration amount range.

[0030] On the other hand, the present invention also provides an ophthalmic Chinese medicine preparation, based on the above-mentioned ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof, the preparation is prepared by extracting, concentrating and drying the effective ingredients of the Chinese herbal raw material composition to prepare Chinese herbal powder, and then dissolving the Chinese herbal powder in hydrogen-rich water;

[0031] Among them, the components of the Chinese herbal raw material composition include 10-15 weight parts of astragalus, 5-10 weight parts of salvia miltiorrhiza, 5-10 weight parts of liquorice, 5-10 weight parts of vitex rotundus, 5-10 weight parts of white peony root, 3-5 weight parts of glutinous rice, 10-15 weight parts of wolfberry, 10-15 weight parts of cassia seed, 3-5 weight parts of dodder seed, 5-10 weight parts of selfheal, 1-5 weight parts of mint, and 1-5 weight parts of chrysanthemum.

[0032] Compared with the prior art, the beneficial effect of the present invention lies in that, by soaking the Chinese herbal raw materials, the dry medicinal materials can fully absorb the solvent, and then the temperature is increased to promote the release of the effective ingredients in each medicinal material, and the soaking process is automatically and intelligently monitored, that is, part of the medicinal materials are periodically grabbed for water content detection, and pressure is applied to them and the quality of the squeezed solution is analyzed, that is, by detecting the mass change of the medicinal materials from a dry state to a wet state, and then the solvent content of the medicinal materials is analyzed. Since the water absorption capacity of specific medicinal materials is limited, that is, when the medicinal materials reach a saturated state, they cannot continue to absorb more solvent, the soaking efficiency is improved by real-time detection of the soaking process. At the same time, the quality of the medicinal materials is also guaranteed. By detecting the temperature increase extraction process, the inactivation of the active ingredients due to excessive temperature is avoided. At the same time, the extraction rate is intelligently calculated, thereby improving the real-time detection and extraction efficiency.

[0033] Furthermore, by setting a standard infiltration amount range, the real-time infiltration amount is compared with the standard infiltration amount range to detect the degree of water absorption of the mixed raw materials in real time. The larger the real-time infiltration amount value, the greater the water absorption degree of the corresponding mixed raw materials. If the real-time infiltration amount is determined to be within the standard infiltration amount range, it means that the moisture content of the mixed raw materials has reached the preset standard, that is, each medicinal material has been completely moistened, and heating extraction will be carried out to accelerate the release rate of effective substances in the medicinal materials.

[0034] Furthermore, by determining that the real-time infiltration amount is less than the first standard infiltration amount, it means that the mixed raw material is still in a relatively dry state at this time, and has not reached the water absorption level required to absorb the soaking liquid to complete the soaking of the mixed raw material. The soaking time of the mixed raw material will be determined to determine whether it is necessary to adjust the soaking liquid ratio to improve the soaking quality and soaking efficiency of the mixed raw material.

[0035] Furthermore, by determining that the real-time infiltration amount is greater than the second standard infiltration amount, the water absorption capacity of the mixed raw materials is very strong at this time, and the purpose of soaking has been achieved. It is necessary to adjust the soaking time in time to avoid the medicinal materials being soaked in the solvent for a long time, which will cause inactivation and weaken the efficacy of the medicinal materials. The microorganisms and molds hidden in the medicinal materials will spread more in the solvent, affecting the safety of the drugs, and the texture of the medicinal materials will become soft, reducing the quality. At the same time, it is ensured that the medicinal materials absorb the solvent to a saturated state to ensure the extraction effect.

[0036] Furthermore, by judging the soaking time of the mixed raw materials that are still in a relatively dry state, that is, comparing the current soaking time with the preset time range, if it is judged that the current soaking time has not reached the preset soaking time, the soaking process continues; if it is judged that the current soaking time has reached the preset soaking time, the mixed raw materials are not completely soaked due to the low proportion of the soaking liquid, and the proportion of the soaking liquid needs to be increased, and the increment increases with the increase of the difference between the current soaking time and the standard soaking time, thereby increasing the accuracy and real-time performance of the adjustment.

[0037] Furthermore, by periodically acquiring images of the solid-liquid mixture, the extraction status of the mixed raw material is characterized according to the color change of the image, thereby increasing the intelligence and real-time performance of the detection. If the real-time brightness difference is determined to be less than or equal to the standard brightness difference, indicating that the color change of the solid-liquid mixture is not obvious, the color change rate of the solid-liquid mixture is determined to monitor the extraction process to determine whether the extraction process of the mixed raw material is completed. If the real-time brightness difference is determined to be greater than the standard brightness difference, indicating that the color change of the solid-liquid mixture is obvious, this is a normal phenomenon caused by the chemical components in the mixed raw material dissolving in the ethanol solution and the dissolution rate being relatively fast.

[0038] Furthermore, the real-time extraction rate is compared with the standard extraction rate to characterize the color change. If the real-time extraction rate is determined to be less than the standard extraction rate, it means that the color change of the solution is slow. In this case, the extraction rate is increased by appropriately changing the temperature. If the real-time extraction rate is determined to be greater than or equal to the standard extraction rate, it means that the color change of the solution is fast. In this case, the extraction efficiency is higher. By detecting the color change of the solution, the intelligence and real-time performance of the detection are improved.

[0039] Furthermore, when it is determined that the color of the solution changes rapidly, the real-time extraction time is determined according to the standard extraction time to determine the extraction progress. If the real-time extraction time is determined to be greater than the standard extraction time, since the active ingredients in the mixed raw materials are still being released and the release rate is high, it is necessary to increase the preset standard extraction time so that the mixed raw materials continue to dissolve in the solution, thereby improving the extraction efficiency and quality.

[0040] Furthermore, through simple calculations, the standard infiltration volume range of the raw materials to be tested can be obtained. As the soaking time increases, the water content of the raw materials to be tested also increases until the raw materials to be tested reach a saturated state. The raw materials cannot absorb more solvent and reach a saturated state. The standard infiltration volume range tends to a constant value. The water absorption of the medicinal materials during the soaking process is analyzed, which increases the real-time nature of the detection, improves the soaking efficiency, and ensures the quality of the medicinal materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1The flowchart of the ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to the embodiment of the present invention;

[0042] Figure 2 It is a structural schematic diagram of an intelligent leaching device according to an embodiment of the present invention;

[0043] Figure 3 It is a logic flow chart of the soaking process of an embodiment of the present invention;

[0044] Figure 4 The figure is a logic flow chart of the extraction process according to an embodiment of the present invention. DETAILED DESCRIPTION

[0045] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0046] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0047] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0048] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0049] See also Figure 1 and Figure 2 As shown, Figure 1 The flowchart of the ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to the embodiment of the present invention is as follows: Figure 2The structural schematic diagram of the intelligent leaching device 1 of the embodiment of the present invention comprises a gripping mechanism 2, a camera mechanism 3, a humidity detection layer 4, a pressing mechanism 5, a pressure sensor 6, and a control mechanism (not shown in the figure), wherein the humidity detection layer 4 is provided with a multi-layer filter screen for filtering the soaking liquid generated by the pressing treatment; the pressure sensor 6 is used to detect the weight of the raw material to be detected before and after the pressing treatment; the control mechanism is used to obtain the pressure detected by the pressure sensor 6 and calculate the weight difference before and after the pressing treatment; the pressing mechanism 5 is used to press the raw material to be detected; the camera mechanism 3 is used to obtain a real-time solution image of the solution of the solid-liquid mixture inside the intelligent leaching device 1; the gripping mechanism 2 is used to grab the mixed raw material inside the intelligent leaching device 1 to the upper surface of the humidity detection layer 4; the present invention provides an ophthalmic Chinese medicine preparation and a method for extracting active ingredients thereof, comprising,

[0050] Step S1, raw material processing, chopping, weighing and mixing the Chinese herbal raw materials respectively to form a mixed raw material, adding the mixed raw material to the intelligent leaching device 1, adding the soaking liquid to the intelligent leaching device 1 to form a solid-liquid mixture, and stirring and mixing the solid-liquid mixture;

[0051] Step S2, soaking, sampling and testing the soaking process of the mixed raw material, determining the real-time soaking amount of the mixed raw material and the standard soaking amount range according to the weight of the raw material to be tested before and after squeezing, and when it is determined that the real-time soaking amount is less than the first standard soaking amount, the current soaking time is determined according to the preset time range to determine whether to determine the preset material-liquid ratio, and when it is determined that the real-time soaking amount is greater than the second standard soaking amount, the first preset time is adjusted;

[0052] Step S3, temperature-raising extraction, when it is determined that the real-time infiltration amount is within the standard infiltration amount range, the solid-liquid mixture is subjected to temperature-raising extraction, a real-time solution image of the solution during the extraction process is obtained, and a real-time brightness difference and a real-time extraction rate are calculated according to the real-time solution image. When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time extraction rate is compared with the standard extraction rate, and when it is determined that the real-time extraction rate is greater than or equal to the standard extraction rate and the real-time extraction time is greater than the standard extraction time, the standard extraction time is adjusted, and when it is determined that the real-time brightness difference is less than or equal to the standard brightness difference and the real-time extraction rate is less than the standard extraction rate, the preset extraction temperature is adjusted;

[0053] Step S4, finished product preparation: filtering the solid-liquid mixture, collecting the filtrate and concentrating it under vacuum to a solid content of 20%-50%, and drying it at low temperature to form Chinese herbal medicine powder.

[0054] By soaking the Chinese herbal raw materials, the dry medicinal materials can fully absorb the solvent, and then the temperature is increased to promote the release of the effective ingredients in each medicinal material. The soaking process is automatically and intelligently monitored, that is, part of the medicinal materials are periodically grabbed for water content detection, and pressure is applied to them and the quality of the squeezed solution is analyzed, that is, by detecting the change in the quality of the medicinal materials from dry state to wet state, the solvent content of the medicinal materials is analyzed. Since the water absorption capacity of certain medicinal materials is limited, that is, when the medicinal materials reach the saturated state, they cannot continue to absorb more solvent. The soaking process is detected in real time to improve the soaking efficiency. At the same time, the quality of the medicinal materials is also guaranteed. By detecting the temperature increase extraction process, the inactivation of active ingredients due to excessive temperature is avoided. At the same time, the extraction rate is intelligently calculated to improve the real-time detection and extraction efficiency.

[0055] See also Figure 3 As shown, it is a logic flow chart of the soaking process of an embodiment of the present invention;

[0056] Specifically, in step S2, a standard infiltration amount range is set, the humidity of the mixed raw material is detected and determined at a number of sampling points, the raw material to be detected is taken from the solid-liquid mixture to the humidity detection layer 4 for squeezing by the grabbing mechanism 2, the weight value of the raw material to be detected before squeezing is obtained and recorded as the real-time infiltration amount, and the real-time infiltration amount is compared with the standard infiltration amount range,

[0057] If the real-time infiltration amount is within the standard infiltration amount range, the real-time brightness difference value is compared with the standard brightness difference value to determine whether the extraction state of the mixed raw material is normal;

[0058] If the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively to determine whether to adjust the immersion state.

[0059] The standard infiltration amount range set in this embodiment represents the mass of the soaking liquid required to infiltrate the mixed raw material to saturation. The set value is related to the water absorption degree of the mixed raw material. Generally, it is set at 1-5 times the weight of the mixed raw material. For example, if the grabbing mechanism 2 grabs 50 grams of the raw material to be tested at a time for weighing, the standard infiltration amount range can be set between 10-50 grams, that is, the weight change of the raw material to be tested before and after pressing is 10-50 grams;

[0060] Several sampling points are the moments when the mixed raw materials are sampled at certain time intervals after the soaking begins, and sampling and judgment can be performed every 10 minutes.

[0061] By setting the standard infiltration amount range, the real-time infiltration amount is compared with the standard infiltration amount range to detect the water absorption degree of the mixed raw materials in real time. The larger the real-time infiltration amount value, the greater the water absorption degree of the corresponding mixed raw materials. If the real-time infiltration amount is determined to be within the standard infiltration amount range, it means that the moisture content of the mixed raw materials has reached the preset standard, that is, each medicinal material has been completely moistened, and heating extraction will be carried out to accelerate the release rate of the effective substances in the medicinal materials.

[0062] Specifically, in step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively.

[0063] If the real-time infiltration amount is less than the first standard infiltration amount, the current infiltration time of the mixed raw material is obtained, and the current infiltration time is compared with the preset time range to determine whether to adjust the first preset time.

[0064] By determining that the real-time infiltration amount is less than the first standard infiltration amount, it means that the mixed raw material is still in a relatively dry state at this time, and has not reached the water absorption level required to absorb the soaking liquid to complete the soaking of the mixed raw material. The soaking time of the mixed raw material will be determined to determine whether it is necessary to adjust the soaking liquid ratio to improve the soaking quality and efficiency of the mixed raw material.

[0065] Specifically, in step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively.

[0066] If the real-time infiltration amount Hs is greater than the second standard infiltration amount Hb2, the current infiltration time of the mixed raw material is obtained, and the first preset time Tc1 is adjusted according to the real-time infiltration amount Hs and the second standard infiltration amount Hb2 to Tc1'=Tc1×[1-(Hb2-Hs) / Hs];

[0067] The first standard infiltration amount Hb1 and the second standard infiltration amount Hb2 constitute a standard infiltration amount range ΔHb, Hb1<Hb2, the first preset time length Tc1 and the second preset time length Tc2 constitute a preset time length range ΔTc, Tc1<Tc2, and the preset time length range is a fixed value;

[0068] The preset time range set in this embodiment indicates the time range required for the mixed raw material to be completely soaked, which is related to the type and shape of the mixed raw material. Generally, it is set between 1-2 hours and is selected according to the actual air-drying degree of the mixed raw material and the extraction requirements;

[0069] By judging that the real-time infiltration amount is greater than the second standard infiltration amount, the water absorption capacity of the mixed raw materials is very strong at this time, and the purpose of soaking has been achieved. It is necessary to adjust the soaking time in time to avoid the medicinal materials being soaked in the solvent for a long time, which will cause inactivation and weaken the efficacy of the medicinal materials. The microorganisms and molds hidden in the medicinal materials will spread more in the solvent, affecting the safety of the drugs, and the texture of the medicinal materials will become soft, reducing the quality. At the same time, it is ensured that the medicinal materials absorb the solvent to a saturated state to ensure the extraction effect.

[0070] Specifically, in step S2, a preset material-liquid ratio of the solid-liquid mixture is set. When it is determined that the real-time infiltration amount of the raw material to be detected is less than the first standard infiltration amount, the current immersion time of the mixed raw material is obtained, and the current immersion time is compared with the preset time range.

[0071] If the current soaking time is less than or equal to the first preset time, the preset material-liquid ratio is not adjusted;

[0072] If the current soaking time Ts is greater than the second preset time Tc2, the preset material-liquid ratio Gc is adjusted according to the current soaking time Ts and the second preset time Tc2, and is adjusted to Gc'=Gc×[1+(Ts-Tc2) / Ts];

[0073] The preset material-liquid ratio set in this embodiment represents the mass ratio of the mixed raw material to the soaking liquid, and is set to 1:8, and is adjusted according to the type and characteristics of the actual mixed raw material, and is selected in the range of 1:7-1:10, and the soaking liquid is an ethanol solution;

[0074] By judging the soaking time of the mixed raw materials that are still in a relatively dry state, that is, comparing the current soaking time with the preset time range, if it is judged that the current soaking time has not reached the preset soaking time, the soaking process continues; if it is judged that the current soaking time has reached the preset soaking time, the mixed raw materials are not completely soaked due to the low proportion of the soaking liquid, and the proportion of the soaking liquid needs to be increased, and the increase increases with the increase of the difference between the current soaking time and the standard soaking time, thereby increasing the accuracy and real-time performance of the adjustment.

[0075] See also Figure 4 As shown, it is a logic flow chart of the extraction process of an embodiment of the present invention;

[0076] Specifically, in step S3, a standard brightness difference value of the solid-liquid mixture is set. When it is determined that the real-time infiltration amount of the mixed raw material is within the standard infiltration amount range, the solid-liquid mixture is heated, and two real-time solution images corresponding to the two end points of the preset detection period are obtained by the camera device 3. The real-time brightness difference value is calculated based on the two real-time solution images, and the real-time brightness difference value is compared with the standard brightness difference value.

[0077] If the real-time brightness difference is less than or equal to the standard brightness difference, the real-time extraction rate of the mixed raw material will be calculated, and the real-time extraction rate will be compared with the standard extraction rate to determine whether to adjust the preset extraction temperature;

[0078] If the real-time brightness difference is greater than the standard brightness difference, it is determined that the extraction state of the mixed raw material is normal.

[0079] The standard brightness difference value set in this embodiment indicates that the color of the solid-liquid mixture solution tends to be unchanged, that is, the color state of the solid-liquid mixture solution reaches the state that the chemical components in the mixed raw materials are completely dissolved in the ethanol solution. The set value is related to the type and composition of the mixed raw materials, and theoretically approaches zero. It is represented by the gray value. Generally, it is set between 0.1-1, and is selected according to the type of the actual mixed raw materials and the performance of the camera mechanism 3. The preset detection period indicates the set extraction detection time of the mixed raw materials. Generally, it is set between 3 minutes and 10 minutes, and is selected according to the actual extraction requirements.

[0080] The real-time brightness difference is calculated by taking the grayscale values ​​of the two images and making the difference. The grayscale value of any image is the average grayscale value of each pixel.

[0081] By periodically acquiring images of the solid-liquid mixture, the extraction status of the mixed raw material is characterized according to the color change of the image, thereby increasing the intelligence and real-time performance of the detection. If the real-time brightness difference is determined to be less than or equal to the standard brightness difference, it means that the color change of the solid-liquid mixture is not obvious. Then, the color change rate of the solid-liquid mixture is determined to monitor the extraction process to determine whether the extraction process of the mixed raw material is completed. If the real-time brightness difference is determined to be greater than the standard brightness difference, it means that the color change of the solid-liquid mixture is obvious. This is a normal phenomenon caused by the chemical components in the mixed raw material dissolving in the ethanol solution and the dissolution rate being relatively fast.

[0082] Specifically, in step S3, a preset extraction temperature and a standard extraction rate for extracting the mixed raw material are set. When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time brightness difference calculated in the previous preset detection period is obtained, and the real-time brightness difference in the current preset detection period is subtracted from the real-time brightness difference in the previous preset detection period and then divided by the preset detection time to obtain the real-time extraction rate of the mixed raw material, and the real-time extraction rate is compared with the standard extraction rate.

[0083] If the real-time extraction rate Vs is less than the standard extraction rate Vb, the preset extraction temperature Qs is adjusted to Qs'=Qs×[1+(Vb-Vs) / Vs],

[0084] Continue to perform the above-mentioned calculation of the real-time brightness difference and the determination operation of comparing the real-time brightness difference with the standard brightness difference until it is determined again that the real-time brightness difference is less than or equal to the standard brightness difference and the real-time extraction rate is less than the standard extraction rate, and the extraction process of the mixed raw material is completed;

[0085] If the real-time extraction rate is greater than or equal to the standard extraction rate, the real-time extraction duration will be judged according to the standard extraction duration to determine whether to adjust the standard extraction duration;

[0086] Among them, Qs'≤50℃;

[0087] The preset extraction temperature set in this embodiment is set to 45°C. Since the appropriate temperature will promote the dissolution of the active ingredients in the mixed raw materials, increasing the temperature is beneficial to the release rate of the active ingredients. However, too high a temperature will cause the active ingredients to be inactivated, resulting in the denaturation of the medicinal materials, thereby affecting the extraction quality and efficiency. Therefore, the setting value of the preset extraction temperature is generally between 45°C and 50°C, and is selected according to the actual type of medicinal materials; the set standard extraction rate indicates how fast the solution color changes, and can be set in the range of 0.4-1.1;

[0088] The color change is characterized by comparing the real-time extraction rate with the standard extraction rate. If the real-time extraction rate is determined to be less than the standard extraction rate, it means that the color change of the solution is slow. In this case, the extraction rate is increased by appropriately changing the temperature. If the real-time extraction rate is determined to be greater than or equal to the standard extraction rate, it means that the color change of the solution is fast. At this time, the extraction efficiency is higher. By detecting the color change of the solution, the intelligence and real-time performance of the detection are improved.

[0089] Specifically, in step S3, a standard extraction time of the mixed raw material is set. When it is determined that the real-time extraction rate Vs is greater than or equal to the standard extraction rate Vb, the real-time extraction time corresponding to the current moment is obtained, and the real-time extraction time is determined according to the standard extraction time.

[0090] If the real-time extraction time is less than or equal to the standard extraction time, the standard extraction time will not be adjusted;

[0091] If the real-time extraction time is longer than the standard extraction time, the standard extraction time Mb is adjusted to Mb'=Mb×[1+(Vs-Vb) / Vs].

[0092] The standard extraction time set in this embodiment is 2 hours;

[0093] When it is determined that the color of the solution changes quickly, the real-time extraction time is determined according to the standard extraction time to determine the extraction progress. If the real-time extraction time is determined to be longer than the standard extraction time, since the active ingredients in the mixed raw materials are still being released and the release rate is high, it is necessary to increase the preset standard extraction time so that the mixed raw materials continue to dissolve in the solution, thereby improving the extraction efficiency and quality.

[0094] Specifically, the weight of the raw material to be tested after the squeezing process is obtained and recorded as the initial raw material weight, and the standard infiltration amount, the first standard infiltration amount, the second standard infiltration amount and the standard infiltration amount range are determined according to the initial raw material weight, the water absorption strength, the current soaking time, the second preset time and the water content difference;

[0095] Among them, Hb=Zs×Pb×Ts / Tc2, Hb1=Hb-ΔS, Hb2=Hb+ΔS, ΔS=0.03×Hb, Hb represents the calculated standard infiltration amount, Zs represents the initial raw material weight after the raw material to be tested is squeezed, Pb represents the water absorption strength of the mixed raw material, Ts represents the current soaking time, Tc2 represents the set second preset time, ΔS represents the set moisture content difference, Hb1 represents the calculated first standard infiltration amount, Hb2 represents the calculated second standard infiltration amount, and the first standard infiltration amount and the second standard infiltration amount constitute the standard infiltration amount range.

[0096] In this embodiment, the water absorption strength is set to 2.5, and the water content difference is the allowable error, which is set to 3% of the standard infiltration amount.

[0097] The standard infiltration volume range of the raw materials to be tested can be obtained through simple calculations. As the soaking time increases, the water content of the raw materials to be tested also increases until the raw materials to be tested reach a saturated state. The raw materials cannot absorb more solvent and reach a saturated state. The standard infiltration volume range tends to a constant value. The water absorption of the medicinal materials during the soaking process is analyzed, which increases the real-time nature of the detection, improves the soaking efficiency, and ensures the quality of the medicinal materials.

[0098] The present invention also provides a Chinese herbal medicine raw material composition, which comprises 10-15 parts by weight of astragalus, 5-10 parts by weight of salvia miltiorrhiza, 5-10 parts by weight of liquorice, 5-10 parts by weight of vitex rotundus, 5-10 parts by weight of white peony root, 3-5 parts by weight of glutinous rice, 10-15 parts by weight of wolfberry, 10-15 parts by weight of cassia seed, 3-5 parts by weight of dodder seed, 5-10 parts by weight of selfheal, 1-5 parts by weight of mint, and 1-5 parts by weight of chrysanthemum.

[0099] Example 1: The components are matched by weight as 10 parts of Astragalus, 10 parts of Salvia miltiorrhiza, 5 parts of Licorice, 5 parts of Vitex rotundifolia, 5 parts of White Peony Root, 3 parts of Gastrodia elata, 12 parts of Lycium barbarum, 13 parts of Cassia seed, 5 parts of Cuscuta seed, 5 parts of Prunella vulgaris, 5 parts of Mentha, and 2 parts of Chrysanthemum.

[0100] Example 2: The components are matched by weight as 13 parts of Astragalus, 10 parts of Salvia miltiorrhiza, 8 parts of Licorice, 5 parts of Vitex rotundifolia, 5 parts of White Peony Root, 5 parts of Gastrodia elata, 10 parts of Lycium barbarum, 12 parts of Cassia seed, 3 parts of Cuscuta seed, 3 parts of Prunella vulgaris, 5 parts of Mentha, and 2 parts of Chrysanthemum.

[0101] The present invention also provides an ophthalmic Chinese medicine preparation, which is obtained by dissolving the prepared Chinese herbal medicine powder in hydrogen-rich water, and adding boric acid or sodium chloride to adjust the pH value to between 6.5 and 7;

[0102] The Chinese herbal medicine preparation of the present invention was used to test the test group, and the use method, experimental data, and experimental results are as follows:

[0103] When using the product, volunteers with visual fatigue should tilt their heads back slightly and look toward the top of their heads. Use the index finger to pull down the lower eyelid to expose the conjunctival sac. Drop the Chinese herbal medicine into the conjunctival sac 1-2 cm above the eyes and gently close the eyes for 5 minutes. Use the product twice a day for one week.

[0104] The test population selected adult volunteers with visual fatigue, ranging in age from 18 to 65 years old, regardless of gender. The test was randomly divided into two groups, the experimental group and the control group, with 60 people in each group.

[0105] Test group: Volunteers with visual fatigue tilted their heads back slightly and looked toward the top of their heads. Pull down the lower eyelid with your index finger to expose the conjunctival sac. Drop hydrogen-rich water into the conjunctival sac 1-2 cm above the eyes and gently close your eyes for 5 minutes. Use twice a day for one week.

[0106] Control Group: The control group did not use any product.

[0107] Before the trial begins, each patient's fatigue, dry eyes, and red bloodshot eyes are recorded; after the trial period, each participant's feelings are assessed, including the above characteristics; a final survey of patients' feelings of improvement is conducted; and any adverse events related to product use, such as allergic reactions or skin irritation, are monitored during the trial.

[0108] The experimental results are shown in Table 1 and Table 2, wherein Table 1 shows the test indicators and results of the Chinese herbal medicine preparation prepared by the medicinal material formula of Example 1 of the present invention, and Table 2 shows the test indicators and results of the Chinese herbal medicine preparation prepared by the medicinal material formula of Example 2 of the present invention;

[0109] Table 1

[0110] index Experimental Group Control group Fatigue relief 89.2％ No improvement Red blood situation 88.3％ No improvement Dry eyes 90.8％ No improvement Patient satisfaction rating 90.5％ No improvement Allergic reaction or skin irritation none none

[0111] Table 2

[0112] index Experimental Group Control group Fatigue relief 91.2％ No improvement Red blood situation 89.3％ No improvement Dry eyes 92.8％ No improvement Patient satisfaction rating 93.6％ No improvement Allergic reaction or skin irritation none none

[0113] The Chinese herbal medicine preparation prepared in this embodiment achieves the effect of preventing and delaying vision growth by relieving eye fatigue and dry eyes, and provides efficacy experimental data that can confirm that the above-mentioned Chinese herbal medicine formula can relieve eye fatigue and dry eyes, and also provides a medicinal material control screening experiment.

[0114] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0115] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine preparation for eyes and a method for extracting active ingredients thereof, characterized in that: include, Step S1, raw material processing, chopping, weighing and mixing the Chinese herbal raw materials respectively to form a mixed raw material, adding the mixed raw material to the intelligent leaching device, adding the immersion liquid to the intelligent leaching device to form a solid-liquid mixture, and stirring and mixing the solid-liquid mixture; Step S2, soaking, sampling and testing the soaking process of the mixed raw material, determining the real-time soaking amount of the mixed raw material and the standard soaking amount range according to the weight of the raw material to be tested before and after squeezing, and when it is determined that the real-time soaking amount is less than the first standard soaking amount, the current soaking time is determined according to the preset time range to determine whether to determine the preset material-liquid ratio, and when it is determined that the real-time soaking amount is greater than the second standard soaking amount, the first preset time is adjusted; Wherein, in the step S2, a standard infiltration amount range is set, the humidity of the mixed raw material is detected and determined at a plurality of sampling points, the raw material to be detected is taken from the solid-liquid mixture to the humidity detection layer for squeezing by a grabbing mechanism, the weight value of the raw material to be detected before squeezing is obtained and recorded as the real-time infiltration amount, and the real-time infiltration amount is compared with the standard infiltration amount range, If the real-time infiltration amount is within the standard infiltration amount range, the real-time brightness difference value is compared with the standard brightness difference value to determine whether the extraction state of the mixed raw material is normal; If the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively to determine whether to adjust the immersion state; If the real-time infiltration amount is less than the first standard infiltration amount, obtaining the current infiltration time of the mixed raw material, and comparing the current infiltration time with the preset time range to determine whether to adjust the preset material-liquid ratio; A preset material-liquid ratio of the solid-liquid mixture is set, and when it is determined that the real-time infiltration amount of the raw material to be detected is less than the first standard infiltration amount, the current immersion time of the mixed raw material is obtained, and the current immersion time is compared with the preset time range, If the current soaking time is longer than the second preset time, the preset material-liquid ratio is adjusted according to the current soaking time and the second preset time; Wherein, Gc'=Gc×[1+(Ts-Tc2) / Ts], Gc represents the preset material-liquid ratio, Gc' represents the adjusted preset material-liquid ratio, Ts represents the current soaking time of the mixed raw material, Tc2 represents the set second preset time, the preset time range is a fixed value, the second preset time is the maximum value of the preset time range, and changes with the first preset time; Step S3, temperature-raising extraction, when it is determined that the real-time infiltration amount is within the standard infiltration amount range, the solid-liquid mixture is subjected to temperature-raising extraction, a real-time solution image of the solution during the extraction process is obtained, and a real-time brightness difference and a real-time extraction rate are calculated according to the real-time solution image. When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time extraction rate is compared with the standard extraction rate, and when it is determined that the real-time extraction rate is greater than or equal to the standard extraction rate and the real-time extraction time is greater than the standard extraction time, the standard extraction time is adjusted, and when it is determined that the real-time brightness difference is less than or equal to the standard brightness difference and the real-time extraction rate is less than the standard extraction rate, the preset extraction temperature is adjusted; Step S4, finished product preparation, filtering the solid-liquid mixture, collecting the filtrate and concentrating and drying it to form Chinese herbal medicine powder; wherein, the first preset time length is the minimum value of the preset time length range, the preset time length range is a fixed value, and the preset time length range is set between 1-2 hours; the first standard infiltration amount is the minimum value of the standard infiltration amount range, and the second standard infiltration amount is the maximum value of the standard infiltration amount range.

2. The ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to claim 1, characterized in that: In step S2, when it is determined that the real-time infiltration amount is not within the standard infiltration amount range, the real-time infiltration amount is compared with the first standard infiltration amount and the second standard infiltration amount respectively. If the real-time infiltration amount is greater than the second standard infiltration amount, obtaining the current infiltration time of the mixed raw material, and adjusting the first preset time according to the real-time infiltration amount and the second standard infiltration amount; Wherein, Tc1'= Tc1×[1-(Hb2-Hs) / Hs], Tc1 represents the set first preset time length, Tc1' represents the adjusted first preset time length, Hb2 represents the set second standard infiltration amount, and Hs represents the calculated real-time infiltration amount of the raw material to be tested.

3. The ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to claim 1, characterized in that: When it is determined that the real-time infiltration amount of the mixed raw material is within the standard infiltration amount range, the solid-liquid mixture is heated, and two real-time solution images corresponding to the two end points of the preset detection time period are obtained by a camera mechanism, and the real-time brightness difference is calculated based on the two real-time solution images, and the real-time brightness difference is compared with the standard brightness difference. When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time extraction rate of the mixed raw material is calculated, and the real-time extraction rate is compared with the standard extraction rate to determine whether to adjust the preset extraction temperature.

4. The ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to claim 3, characterized in that: When it is determined that the real-time brightness difference is less than or equal to the standard brightness difference, the real-time brightness difference calculated in the previous preset detection period is obtained, and the real-time brightness difference in the current preset detection period is subtracted from the real-time brightness difference in the previous preset detection period and then divided by the preset detection time to obtain the real-time extraction rate of the mixed raw material, and the real-time extraction rate is compared with the standard extraction rate. If the real-time extraction rate is greater than or equal to the standard extraction rate, the real-time extraction duration will be judged according to the standard extraction duration to determine whether to adjust the standard extraction duration; If the real-time extraction rate is less than the standard extraction rate, the preset extraction temperature is adjusted, and the above-mentioned calculation of the real-time brightness difference and the determination operation of comparing the real-time brightness difference with the standard brightness difference are continued, until it is determined again that the real-time brightness difference is less than or equal to the standard brightness difference, and the real-time extraction rate is less than the standard extraction rate, the extraction process of the mixed raw material is completed; Wherein, Qs'=Qs×[1+(Vb-Vs) / Vs], Qs represents the set preset extraction temperature, Qs' represents the adjusted preset extraction temperature, Vb represents the set standard extraction rate, and Vs represents the calculated real-time extraction rate.

5. The ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to claim 4, characterized in that: In step S3, a standard extraction time of the mixed raw material is set. When it is determined that the real-time extraction rate is greater than or equal to the standard extraction rate, the real-time extraction time corresponding to the current moment is obtained, and the real-time extraction time is determined according to the standard extraction time. If the real-time extraction time is longer than the standard extraction time, the standard extraction time will be adjusted; Among them, Mb'=Mb×[1+(Vs-Vb) / Vs], Mb represents the set standard extraction time, Mb' represents the adjusted standard extraction time, Vs represents the calculated real-time extraction rate, and Vb represents the set standard extraction rate.

6. The ophthalmic Chinese medicine preparation and the method for extracting the active ingredients thereof according to claim 1, characterized in that: The weight of the raw material to be tested after the squeezing process is obtained and recorded as the initial raw material weight, and the standard infiltration amount, the first standard infiltration amount, the second standard infiltration amount and the standard infiltration amount range are determined according to the initial raw material weight, the water absorption strength, the current soaking time, the second preset time and the water content difference; Among them, Hb=Zs×Pb×Ts / Tc2, Hb1= Hb-ΔS, Hb2= Hb+ΔS, Hb represents the calculated standard infiltration amount, Zs represents the initial raw material weight after the raw material to be tested is squeezed, Pb represents the water absorption strength of the mixed raw material, Ts represents the current soaking time, Tc2 represents the set second preset time, ΔS represents the set moisture content difference, Hb1 represents the calculated first standard infiltration amount, Hb2 represents the calculated second standard infiltration amount, and the first standard infiltration amount and the second standard infiltration amount constitute the standard infiltration amount range.

7. An ophthalmic Chinese medicine preparation, based on the ophthalmic Chinese medicine preparation and the method for extracting active ingredients thereof according to claims 1-6, characterized in that: The preparation is prepared by extracting, concentrating and drying the effective components of the Chinese herbal raw material composition to prepare Chinese herbal powder, and then dissolving the Chinese herbal powder in hydrogen-rich water; Among them, the components of the Chinese herbal raw material composition include 10-15 weight parts of astragalus, 5-10 weight parts of salvia miltiorrhiza, 5-10 weight parts of liquorice, 5-10 weight parts of vitex rotundus, 5-10 weight parts of white peony root, 3-5 weight parts of glutinous rice, 10-15 weight parts of wolfberry, 10-15 weight parts of cassia seed, 3-5 weight parts of dodder seed, 5-10 weight parts of selfheal, 1-5 weight parts of mint, and 1-5 weight parts of chrysanthemum.

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