A pulverizing device for producing and processing amorolfine hydrochloride liniment

Abstract

The present invention belongs to the technical field of drug pulverization, and specifically is a pulverizing device for the production and processing of amorolfine hydrochloride ointment, comprising a base frame, a stirring structure is provided on the upper surface of the base frame, a connecting structure is provided on one end of the upper surface of the base frame close to the stirring structure, and a crushing structure is provided on one side of the connecting structure; the crushing structure comprises: a crushing frame. By setting an extrusion frame, when the acrylic resin is pulverized, the auxiliary steel balls arranged below the first crushing roller and the second crushing roller can fully pulverize the acrylic resin. Since a plurality of small holes are provided on the side wall of the extrusion frame, and the holes are inclined, the higher end is close to the inside of the extrusion frame, and the lighter dust will not pass through the holes. At this time, the upper adjustment cover above the extrusion frame can not only suppress the dust when the acrylic resin is pulverized, but the small holes on the side wall of the extrusion frame can also make the extrusion frame have good heat dissipation.

Description

Technical Field

[0001] The invention belongs to the technical field of drug pulverization, in particular to a pulverizing device for the production and processing of amorolfine hydrochloride ointment. Background Art

[0002] Amorolfine hydrochloride ointment is a drug used to treat various dermatophytosis. It is mainly prepared from anhydrous ethanol, acrylic resin, ethyl acetate and other raw materials. When preparing amorolfine hydrochloride ointment, the acrylic resin will be dissolved in the solvent to form a uniform solution or suspension. Therefore, when preparing amorolfine hydrochloride ointment, the acrylic resin will be crushed into resin powder.

[0003] A patent application with publication number CN210449299U discloses a drug crusher, including a chopping chamber and a crushing chamber, wherein a chopping motor is installed at the bottom end of the chopping chamber, and the output shaft of the chopping motor is fixed to a chopping rod, the chopping rod is arranged inside the chopping chamber, and the crushing chamber is installed at the middle of the top end of the chopping chamber, and a filter plate is arranged at the bottom end of the crushing chamber, the disc is driven to rotate by the crushing motor, the disc drives the protrusion to rotate, the protrusion drives the fixed block by driving the connecting rod, so that the fixed block drives the slider to slide up and down on the slide groove on the slide rail, so that the slider drives the impact block to crush the impact chamber through the fixed rod, so that large drugs can be crushed for pre-treatment, thereby improving the efficiency of drug crushing.

[0004] There are still some problems in the actual application of the above scheme. When the drug is crushed, the drug is crushed by the up and down reciprocating motion of the impact block. In the process of crushing, the interaction between the drugs will generate shear force. These shear forces act on the tiny particles on the surface of the drug, separating them from the larger particles and suspending them in the air, forming dust. These dusts will reduce the visibility of the working environment and even enter the crushing equipment, affecting the normal operation and service life of the equipment. In order to solve this problem, a sealing cover will be set inside the crushing device to isolate the crushing environment from the external environment. However, the installation of a sealing cover will limit the flow of air around the equipment, thereby affecting the heat dissipation effect of the equipment, and will also limit the operator's line of sight and operating space.

[0005] To this end, the present invention provides a pulverizing device for the production and processing of amorolfine hydrochloride ointment. Summary of the invention

[0006] In order to make up for the deficiencies of the prior art, at least one technical problem raised in the background technology is solved.

[0007] The technical solution adopted by the present invention to solve the technical problem is as follows: a pulverizing device for the production and processing of amorolfine hydrochloride ointment described in the present invention comprises a base frame, a stirring structure is arranged on the upper surface of the base frame, a connecting structure is arranged on one end of the upper surface of the base frame close to the stirring structure, and a crushing structure is arranged on one side of the connecting structure; the crushing structure comprises: a crushing frame, the crushing frame is rotatably connected to one end of the connecting structure; an extrusion frame, the extrusion frame is arranged on the surface of the crushing frame, and a plurality of holes are opened on the side wall of the extrusion frame, and the surface of the crushing frame at the bottom of the extrusion frame is inclined; a driving shaft, the driving shaft is rotatably connected to the inside of the crushing frame; A first crushing roller, the first crushing roller is arranged inside the extrusion frame, and the first crushing roller is connected to the driving shaft; a second crushing roller, the second crushing roller is arranged inside the extrusion frame; auxiliary steel balls, the lower ends of the first crushing roller and the second crushing roller are both provided with auxiliary steel balls; a scraping plate, the scraping plate is arranged between the crushing frame and the extrusion frame, the scraping plate is in contact with the outer wall of the extrusion frame, and the scraping plate is connected to the connecting structure; a feeding pipe, the feeding pipe is arranged at the lower end of the crushing frame; the stirring structure includes: a stirring frame, the stirring frame is arranged on the upper surface of the base frame; a connecting arm, the connecting arm is arranged on the arc surface of the driving shaft; a stirring rod, the stirring rod is connected to the connecting arm.

[0008] Preferably, the connecting structure includes: a connecting frame, which is arranged at the upper end of the base frame, and the crushing frame is rotatably connected to the surface of the connecting frame, and the scraping plate is connected to the connecting frame; the stirring structure also includes: a hidden half ring, which is arranged at the upper end of the stirring frame, and the material passing pipe passes through the surface of the hidden half ring; the crushing structure also includes: a lower adjusting cover, which is arranged at the upper end of the extrusion frame.

[0009] Preferably, an upper adjusting cover is provided above the lower adjusting cover, and the upper adjusting cover is in contact with the lower adjusting cover.

[0010] Preferably, the upper adjustment cover and the lower adjustment cover are internally slidably connected with a sliding rod, the arc surface of the sliding rod is sleeved with a tension spring, and the tension spring is in contact with the upper adjustment cover, one end of the sliding rod is provided with a rotating shaft, the arc surface of the rotating shaft is rotatably connected with a contact bar, and the contact bar is inclined in an initial state, and an adjustment block is provided at one end of the abutment bar close to the tension spring, and the adjustment block is in contact with the tension spring.

[0011] Preferably, a pressing spring is provided at one end of the adjusting block, and one end of the pressing spring is connected to the abutting strip.

[0012] Preferably, an abutment block is provided at the upper end of the driving shaft, and the inclined surface of the abutment block is in contact with the abutment strip.

[0013] Preferably, a feeding port is provided on the surface of the upper adjustment cover and the lower adjustment cover, a sliding groove is provided on one end of the surface of the upper adjustment cover close to the sliding rod, and the sliding rod slides on the inner wall of the sliding groove.

[0014] Preferably, a fixing buckle is provided on the inner wall of the slide groove, and the fixing buckle is in contact with the sliding rod.

[0015] Preferably, an adjusting spring is provided between the connecting arm and the stirring rod, and a scraping knife is provided at one end of the stirring rod close to the stirring frame, and the scraping knife is in contact with the inner wall of the stirring frame.

[0016] Preferably, a sliding groove is provided at one end of the side wall of the connection frame close to the stirring frame, and an adjusting clip is slidably connected to the inner wall of the sliding groove, and the adjusting clip is in contact with the stirring frame.

[0017] The beneficial effects of the present invention are as follows:

[0018] 1. A pulverizing device for the production and processing of amorolfine hydrochloride ointment according to the present invention is provided with an extrusion frame. When pulverizing acrylic resin, the acrylic resin is first placed inside the extrusion frame, and then the driving shaft is started. The first crushing roller and the second crushing roller on the arc surface of the driving shaft will pulverize the acrylic resin inside the extrusion frame, and the auxiliary steel balls arranged below the first crushing roller and the second crushing roller can fully pulverize the acrylic resin. Since a plurality of small holes are provided on the side wall of the extrusion frame, and the holes are provided at an angle, and the higher end is close to the inside of the extrusion frame, lighter dust will not pass through the holes. At this time, the upper adjustment cover above the extrusion frame can not only suppress dust when the acrylic resin is pulverized, but the small holes provided on the side wall of the extrusion frame can also make the extrusion frame have good heat dissipation.

[0019] 2. The pulverizing device for the production and processing of amorolfine hydrochloride ointment described in the present invention has a scraping knife. When the pulverized acrylic resin enters the interior of the stirring frame and is stirred with anhydrous ethanol, the scraping knife arranged at one end of the stirring rod can cyclically scrape the inner wall of the stirring frame, thereby scraping some resins that are clumped and adhered to the inner wall of the stirring frame as particles. The length of the scraping knife is just enough to fit completely with the inner wall of the stirring frame, and the adjustment spring arranged at the other end of the stirring rod can also make the scraping of the scraping knife adaptively adjusted to achieve precise scraping. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The present invention will be further described below in conjunction with the accompanying drawings.

[0021] Figure 1 is a three-dimensional diagram of the first embodiment of the present invention;

[0022] Figure 2 is a front view of the first embodiment of the present invention;

[0023] Figure 3 is an internal view of the crushing frame of the present invention;

[0024] Figure 4 is a three-dimensional diagram of the first crushing roller and the second crushing roller of the present invention;

[0025] Figure 5 It is a position diagram of the extrusion frame and the scraping plate of the present invention;

[0026] Figure 6 It is a position diagram of the upper adjustment cover and the lower adjustment cover of the present invention;

[0027] Figure 7 yes Figure 6 A partial enlarged view of the middle part;

[0028] Figure 8 It is a position diagram of the upper adjustment cover and the slide slot of the present invention;

[0029] Fig. 9 is a position diagram of the upper adjustment cover and the abutment strip of the present invention;

[0030] Fig.10 yes Fig. 9 A partial enlarged view of point B in the middle;

[0031] Fig.11 is an internal view of the stirring frame of the present invention;

[0032] In the figure: 1. base frame; 2. connecting structure; 21. connecting frame; 22. sliding groove; 3. stirring structure; 31. stirring frame; 32. adjusting card strip; 33. hidden half ring; 34. connecting arm; 35. adjusting spring; 36. stirring rod; 37. scraping knife; 4. crushing structure; 401. driving shaft; 402. crushing frame; 403. extrusion frame; 404. upper adjusting cover; 405. lower adjusting cover; 406. first crushing roller; 407. second crushing roller; 408. auxiliary steel ball; 409. feeding pipe; 410. abutment block; 411. scraping plate; 412. feeding port; 413. stretching spring; 414. sliding rod; 415. rotating shaft; 416. abutment strip; 417. pressing spring; 418. sliding groove; 419. fixing buckle; 420. adjusting block. DETAILED DESCRIPTION

[0033] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0034] Embodiment 1

[0035] like Figures 1 to 11As shown, a pulverizing device for the production and processing of amorolfine hydrochloride ointment according to an embodiment of the present invention comprises a base frame 1, a stirring structure 3 is provided on the upper surface of the base frame 1, a connecting structure 2 is provided on one end of the upper surface of the base frame 1 close to the stirring structure 3, and a crushing structure 4 is provided on one side of the connecting structure 2; the crushing structure 4 comprises: a crushing frame 402, the crushing frame 402 is rotatably connected to one end of the connecting structure 2; an extrusion frame 403, the extrusion frame 403 is arranged on the surface of the crushing frame 402, and a plurality of holes are opened on the side wall of the extrusion frame 403, and the surface of the crushing frame 402 at the bottom of the extrusion frame 403 is inclined; a driving shaft 401, the driving shaft 401 is rotatably connected to the inside of the crushing frame 402; a first crushing roller 406, the first crushing roller 406 is arranged inside the extrusion frame 403 , and the first crushing roller 406 is connected to the driving shaft 401; the second crushing roller 407, the second crushing roller 407 is arranged inside the extrusion frame 403; the auxiliary steel ball 408, the lower ends of the first crushing roller 406 and the second crushing roller 407 are both provided with auxiliary steel balls 408; the scraping plate 411, the scraping plate 411 is arranged between the crushing frame 402 and the extrusion frame 403, and the scraping plate 411 is in contact with the outer wall of the extrusion frame 403, and the scraping plate 411 is connected to the connecting structure 2; the feeding pipe 409, the feeding pipe 409 is arranged at the lower end of the crushing frame 402; the stirring structure 3 includes: a stirring frame 31, the stirring frame 31 is arranged on the upper surface of the base frame 1; the connecting arm 34, the connecting arm 34 is arranged on the arc surface of the driving shaft 401; the stirring rod 36, the stirring rod 36 is connected to the connecting arm 34.

[0036] Specifically, a pulverizing device for the production and processing of amorolfine hydrochloride ointment in the scheme is used for producing and preparing amorolfine hydrochloride ointment. When producing amorolfine hydrochloride ointment, it is first necessary to prepare anhydrous ethanol, acrylic resin, ethyl acetate and other raw materials for preparing amorolfine hydrochloride ointment, and then pour the anhydrous ethanol into the interior of the stirring frame 31. After a period of time, a certain amount of amorolfine hydrochloride raw material is dissolved in the anhydrous ethanol. The amorolfine hydrochloride raw material is an antifungal drug. The driving shaft 401 is started, and the driving shaft 401 will drive the stirring rod 36 to stir the anhydrous ethanol and the amorolfine hydrochloride raw material, and stir until they are completely dissolved. During the stirring process, auxiliary materials such as acrylic resin are gradually added to the solution, and stirring is continued until uniform, and then added. Ethyl acetate, butyl acetate, triacetin and other solvents are added to adjust the volume to the required volume, and filtered to remove insoluble matter or impurities to prepare amorolfine hydrochloride liniment. However, since the acrylic resin will be dissolved in the solvent to form a uniform solution or suspension when preparing the amorolfine hydrochloride liniment, the acrylic resin will be crushed into resin powder when preparing the amorolfine hydrochloride liniment. However, since the weight of the resin powder is relatively light, it is very difficult to transport the resin powder. For this reason, a feed pipe 409 is provided above the stirring frame 31, and an acrylic resin crushing device is provided above the feed pipe 409. After the acrylic resin is crushed, it directly enters the interior of the stirring frame 31 through the feed pipe 409, so that the transportation is more convenient. The acrylic resin is crushed by mechanical grinding, ball milling, etc., and the acrylic resin is refined by friction and impact. This crushing method will generate shear force between the acrylic resins. These shear forces act on the tiny particles on the surface of the acrylic resin, so that they are separated from the larger particles and suspended in the air, forming dust. These dusts will reduce the visibility of the working environment. In order to solve this problem, a sealing cover is placed at the position of the crushing device. However, the installation of the sealing cover will limit the flow of air around the crushing device, thereby affecting the heat dissipation effect of the crushing device, and will also limit the operator's line of sight and operating space. For this purpose, a crushing structure 4 is designed. When it is necessary to produce amorolfine hydrochloride paste, the solid acrylic resin is first placed in the extrusion frame 403. The interior of the extrusion frame 403 is then closed, and the driving shaft 401 and the crushing frame 402 are started. The crushing frame 402 will drive the extrusion frame 403 to rotate, and the driving shaft 401 will rotate in the opposite direction to the crushing frame 402. The driving shaft 401 will drive the first crushing roller 406 and the second crushing roller 407 to rotate during the rotation. The first crushing roller 406 and the second crushing roller 407 will crush the acrylic resin inside the extrusion frame 403, and the auxiliary steel balls 408 under the first crushing roller 406 and the second crushing roller 407 will also crush the acrylic resin at the bottom of the extrusion frame 403, so that the solid acrylic resin is crushed into resin powder. When the acrylic resin is crushed into the required size,The first crushing roller 406 and the second crushing roller 407 will squeeze out the resin powder from the holes on the side wall of the extrusion frame 403, and some resin powder stuck in the holes will be scraped by the scraping plate 411 due to the rotation of the crushing frame 402. Since the holes on the side wall of the extrusion frame 403 are inclined, dust will not pass through the holes, which not only achieves the effect of dust suppression, but also does not affect heat dissipation. Finally, the crushed resin powder will enter the interior of the stirring frame 31 through the feeding pipe 409 for stirring.

[0037] like Figures 1 to 11 As shown, the connection structure 2 includes: a connection frame 21, which is arranged at the upper end of the base frame 1, and the crushing frame 402 is rotatably connected to the surface of the connection frame 21, and the scraping plate 411 is connected to the connection frame 21; the stirring structure 3 also includes: a hidden half ring 33, which is arranged at the upper end of the stirring frame 31, and the material passing pipe 409 passes through the surface of the hidden half ring 33; the crushing structure 4 also includes: a lower adjustment cover 405, which is arranged at the upper end of the extrusion frame 403.

[0038] Specifically, when it is necessary to produce amorolfine hydrochloride cream, firstly, solid acrylic resin is placed into the interior of the extrusion frame 403, and then the lower adjustment cover 405 is placed on the upper end of the extrusion frame 403 to close the top of the extrusion frame 403, and the crushing frame 402 is started, and the crushing frame 402 will drive the extrusion frame 403 to rotate on the surface of the connecting frame 21.

[0039] like Figures 1 to 6 As shown, an upper adjusting cover 404 is provided above the lower adjusting cover 405 , and the upper adjusting cover 404 is in contact with the lower adjusting cover 405 .

[0040] Specifically, during the acrylic resin crushing process, some dust generated by the crushing will stick to the lower surface of the lower adjusting cover 405. When the dust accumulates, it will form acrylic resin blocks. Moreover, these acrylic resin blocks are still useful. For this reason, an upper adjusting cover 404 is provided. When the acrylic resin is crushed, the upper adjusting cover 404 is started, and the upper adjusting cover 404 will perform a lifting movement above the lower adjusting cover 405, and will continuously contact the lower adjusting cover 405 during the movement, causing the lower adjusting cover 405 to vibrate, thereby preventing the acrylic resin blocks from sticking to the lower surface of the lower adjusting cover 405 and being difficult to remove.

[0041] like Figures 1 to 7As shown, the upper adjustment cover 404 and the lower adjustment cover 405 are internally slidably connected by a sliding rod 414, the arc surface of the sliding rod 414 is covered with a tension spring 413, and the tension spring 413 is in contact with the upper adjustment cover 404, a rotating shaft 415 is provided at one end of the sliding rod 414, the arc surface of the rotating shaft 415 is rotatably connected with a contact bar 416, and the contact bar 416 is inclined in the initial state, and an adjustment block 420 is provided at one end of the contact bar 416 close to the tension spring 413, and the adjustment block 420 is in contact with the tension spring 413.

[0042] Specifically, when the acrylic resin is crushed, the abutment bar 416 is started, and the abutment bar 416 will drive the adjustment block 420 to move upward, and the adjustment block 420 will contact the tension spring 413 during the upward movement, so that the tension spring 413 moves upward together. When it moves to a certain distance, the compression force of the tension spring 413 is too large. At this time, the tension spring 413 will release the elastic force, and finally the tension spring 413 will abut against the upper adjustment cover 404 and the lower adjustment cover 405, thereby realizing the vibration of the lower adjustment cover 405.

[0043] like Figure 6 to Figure 7 As shown, a pressing spring 417 is provided at one end of the adjusting block 420 , and one end of the pressing spring 417 is connected to the abutting strip 416 .

[0044] Specifically, by setting the pressing spring 417, since the adjusting block 420 needs to drive the stretching spring 413 to move upward, but at this time the abutting bar 416 drives the adjusting block 420 to perform a circular motion, the stretching spring 413 is set, and the distance between the adjusting block 420 and the stretching spring 413 can be adaptively adjusted during the process in which the abutting bar 416 drives the adjusting block 420 to move.

[0045] like Figure 3 As shown, an abutment block 410 is disposed at the upper end of the driving shaft 401 , and the inclined surface of the abutment block 410 is in contact with the abutment bar 416 .

[0046] Specifically, by setting the abutment block 410, since the active shaft 401 will rotate in the opposite direction to the extrusion frame 403 during the rotation of the extrusion frame 403, the inclined surface of the abutment block 410 will contact the abutment bar 416 during the rotation, thereby slowly pressing the abutment bar 416 downward, and when the abutment block 410 is not in contact with the abutment bar 416, the tension spring 413 will release the elastic force, thereby realizing automatic vibration of the lower adjustment cover 405.

[0047] like Figures 6 to 9 As shown, a feeding port 412 is provided on the surface of the upper adjustment cover 404 and the lower adjustment cover 405 . A sliding groove 418 is provided on one end of the surface of the upper adjustment cover 404 close to the sliding rod 414 , and the sliding rod 414 slides on the inner wall of the sliding groove 418 .

[0048] Specifically, by opening a slide groove 418 and a feed port 412 on the surface of the upper adjusting cover 404, when solid acrylic resin needs to be added to the inside of the extrusion frame 403, it only needs to be put in from the feed port 412, and then the upper adjusting cover 404 is rotated. The upper adjusting cover 404 will seal the feed port 412 during the rotation process, thereby achieving the closure of the upper end of the extrusion frame 403.

[0049] like Fig.10 As shown, a fixing buckle 419 is provided on the inner wall of the slide slot 418 , and the fixing buckle 419 is in contact with the sliding rod 414 .

[0050] Specifically, by setting a fixed buckle 419, when the upper adjustment cover 404 rotates, the sliding rod 414 will slide on the inner wall of the slide groove 418. When sliding to the target position, the sliding rod 414 will contact the fixed buckle 419, thereby limiting the upper adjustment cover 404.

[0051] Embodiment 2

[0052] like Fig.11 As shown, compared with Example 1, another embodiment of the present invention is: an adjustment spring 35 is provided between the connecting arm 34 and the stirring rod 36, a scraper 37 is provided at one end of the stirring rod 36 close to the stirring frame 31, and the scraper 37 is in contact with the inner wall of the stirring frame 31.

[0053] Specifically, by providing a scraper 37, when the stirring rod 36 stirs the anhydrous ethanol and the amorolfine hydrochloride raw material, the scraper 37 located at one end of the stirring rod 36 will contact the inner wall of the stirring frame 31, so that some resins that are clumped and adhered to the inner wall of the stirring frame 31 are scraped as particles, and the adjustment spring 35 provided at the other end of the stirring rod 36 can also make the scraping of the scraper 37 adaptively adjusted to achieve precise scraping.

[0054] like Figure 2 As shown, a sliding groove 22 is provided at one end of the side wall of the connecting frame 21 close to the stirring frame 31 , and an adjusting clip 32 is slidably connected to the inner wall of the sliding groove 22 , and the adjusting clip 32 is in contact with the stirring frame 31 .

[0055] Specifically, by setting the adjustment strip 32, after the production of amorolfine hydrochloride ointment is completed, the stirring frame 31 needs to be removed from the upper surface of the base frame 1. At this time, the adjustment strip 32 is started, and the adjustment strip 32 will move in the direction away from the stirring frame 31 to facilitate the removal of the stirring frame 31. When the amorolfine hydrochloride ointment is produced, the adjustment strip 32 is started again, and the adjustment strip 32 will move in the direction close to the stirring frame 31, thereby fixing the stirring frame 31 and making the stirring frame 31 more stable during stirring.

[0056] Working principle: When producing amorolfine hydrochloride liniment, firstly, it is necessary to prepare the raw materials for preparing amorolfine hydrochloride liniment such as anhydrous ethanol, acrylic resin, ethyl acetate, etc., and then pour the anhydrous ethanol into the interior of the stirring frame 31. After a period of time, a certain amount of amorolfine hydrochloride raw material is dissolved in the anhydrous ethanol. The amorolfine hydrochloride raw material is an antifungal drug. Start the driving shaft 401, and the driving shaft 401 will drive the stirring rod 36 to stir the anhydrous ethanol and the amorolfine hydrochloride raw material until they are completely dissolved. During the stirring process, Put the solid acrylic resin into the feeding port 412, and then rotate the upper adjusting cover 404. The upper adjusting cover 404 will seal the feeding port 412 during the rotation process, so that the upper end of the extrusion frame 403 is closed. At this time, the crushing frame 402 is started to rotate, and the crushing frame 402 will drive the extrusion frame 403 to rotate, and the rotation direction of the crushing frame 402 is opposite to that of the driving shaft 401. The driving shaft 401 will drive the first crushing roller 406 and the second crushing roller 407 to rotate during the rotation process. The crushing roller 407 will crush the acrylic resin inside the extrusion frame 403, and the auxiliary steel balls 408 under the first crushing roller 406 and the second crushing roller 407 will also crush the acrylic resin at the bottom of the extrusion frame 403, so that the solid acrylic resin is crushed into resin powder. When the acrylic resin is crushed into a required size, it will be squeezed out from the holes opened in the side wall of the extrusion frame 403 by the first crushing roller 406 and the second crushing roller 407, and some resin powder stuck in the holes will also be squeezed out due to the rotation of the crushing frame 402. The scraping plate 411 scrapes, and because the holes on the side wall of the extrusion frame 403 are inclined, dust will not pass through the holes, which not only achieves the effect of dust suppression, but also does not affect heat dissipation. The crushed resin powder will then pass through the feed pipe 409 into the interior of the stirring frame 31 for stirring. When auxiliary materials such as resin powder are gradually added to the solution, stirring is continued until it is uniform, and then solvents such as ethyl acetate, butyl acetate, and triacetin are added to adjust the volume to the required volume, and filtered to remove insoluble matter or impurities, thereby preparing amorolfine hydrochloride ointment.

[0057] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A pulverizing device for the production and processing of amorolfine hydrochloride liniment, characterized in that: It comprises a base frame (1), a stirring structure (3) is provided on the upper surface of the base frame (1), a connecting structure (2) is provided at one end of the upper surface of the base frame (1) close to the stirring structure (3), and a crushing structure (4) is provided on one side of the connecting structure (2); The crushing structure (4) comprises: A crushing frame (402), wherein the crushing frame (402) is rotatably connected to one end of the connecting structure (2); An extrusion frame (403), the extrusion frame (403) being arranged on the surface of the crushing frame (402), and a plurality of holes being opened on the side wall of the extrusion frame (403), and the holes being opened at an angle, with the higher end being close to the interior of the extrusion frame (403); A driving shaft (401), the driving shaft (401) being rotatably connected to the interior of the crushing frame (402); A first crushing roller (406), the first crushing roller (406) being arranged inside the extrusion frame (403), and the first crushing roller (406) being connected to the driving shaft (401); a second crushing roller (407), the second crushing roller (407) being arranged inside the extrusion frame (403); Auxiliary steel balls (408), the lower ends of the first crushing roller (406) and the second crushing roller (407) are both provided with auxiliary steel balls (408); A scraping plate (411), the scraping plate (411) being arranged between the crushing frame (402) and the extrusion frame (403), the scraping plate (411) being in contact with an outer wall of the extrusion frame (403), and the scraping plate (411) being connected to the connection structure (2); A material passage pipe (409), wherein the material passage pipe (409) is arranged at the lower end of the crushing frame (402); The stirring structure (3) comprises: A stirring frame (31), wherein the stirring frame (31) is arranged on the upper surface of the base frame (1); A connecting arm (34), wherein the connecting arm (34) is arranged on the arc surface of the driving shaft (401); A stirring rod (36), wherein the stirring rod (36) is connected to the connecting arm (34).

2. A pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 1, characterized in that: The connection structure (2) comprises: A connecting frame (21), wherein the connecting frame (21) is arranged at the upper end of the base frame (1), and the crushing frame (402) is rotatably connected to the surface of the connecting frame (21), and the scraping plate (411) is connected to the connecting frame (21); The stirring structure (3) further comprises: A hidden half ring (33), wherein the hidden half ring (33) is arranged at the upper end of the stirring frame (31), and the material passage pipe (409) passes through the surface of the hidden half ring (33); The crushing structure (4) further comprises: A lower adjustment cover (405) is arranged at the upper end of the extrusion frame (403).

3. A pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 2, characterized in that: An upper adjustment cover (404) is provided above the lower adjustment cover (405), and the upper adjustment cover (404) is in contact with the lower adjustment cover (405).

4. A pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 3, characterized in that: The upper adjustment cover (404) and the lower adjustment cover (405) are internally slidably connected to each other by a sliding rod (414); a tension spring (413) is sleeved on the circular arc surface of the sliding rod (414), and the tension spring (413) is in contact with the upper adjustment cover (404); a rotating shaft (415) is provided at one end of the sliding rod (414); a contact bar (416) is rotatably connected to the circular arc surface of the rotating shaft (415), and the contact bar (416) is inclined in an initial state; an adjustment block (420) is provided at one end of the contact bar (416) close to the tension spring (413), and the adjustment block (420) is in contact with the tension spring (413).

5. A pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 4, characterized in that: A pressing spring (417) is provided at one end of the adjusting block (420), and one end of the pressing spring (417) is connected to the abutting strip (416).

6. A pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 5, characterized in that: An abutment block (410) is provided at the upper end of the driving shaft (401), and the inclined surface of the abutment block (410) is in contact with the abutment bar (416).

7. The pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 4, characterized in that: The surfaces of the upper adjustment cover (404) and the lower adjustment cover (405) are both provided with a feeding port (412), and a sliding groove (418) is provided at one end of the surface of the upper adjustment cover (404) close to the sliding rod (414), and the sliding rod (414) slides on the inner wall of the sliding groove (418).

8. The pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 7, characterized in that: A fixing buckle (419) is provided on the inner wall of the slide groove (418), and the fixing buckle (419) is in contact with the sliding rod (414).

9. The pulverizing device for producing and processing amorolfine hydrochloride liniment according to claim 1, characterized in that: An adjusting spring (35) is provided between the connecting arm (34) and the stirring rod (36); a scraping knife (37) is provided at one end of the stirring rod (36) close to the stirring frame (31); and the scraping knife (37) is in contact with the inner wall of the stirring frame (31).

10. The pulverizing device for the production and processing of amorolfine hydrochloride liniment according to claim 2, characterized in that: A sliding groove (22) is provided at one end of the side wall of the connection frame (21) close to the stirring frame (31), and an adjusting clip (32) is slidably connected to the inner wall of the sliding groove (22), and the adjusting clip (32) is in contact with the stirring frame (31).

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