Modeling device for automatically and integrally constructing depression of rats and mice

Abstract

The invention relates to an automatic integrated rat and mouse depression modeling device, which belongs to the technical field of medical instruments and comprises a spliced basic experiment cage, a water control function part, a precise mouse trapping and tail clamping function part, an oscillation rotating mechanism, a spliced mouse activity plate, an electric telescopic column and a central controller. By combining a module structure capable of realizing sealed splicing with an existing basic experiment cage, the emergency stimulation function modules are flexibly added and replaced, and the standardized emergency stimulation modules are matched; therefore, one basic experiment cage can be matched with various standard emergency stimulation modules with different functions to form convenient compatible replacement of different experiment items. Through the combination of the position signal transmitter and the position signal recognizer, the tail area can be accurately recognized when the tail is clamped, flexible and stable clamping is matched, the tail is accurately and stably clamped, and the accuracy of an experimental result is improved.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, and in particular to an automated integrated depression modeling device for mice and rats. Background Art

[0002] In the experiment of exploring the pathogenesis of depression, the animal model of depression using stress as the stressor of depression has been widely recognized at home and abroad. Among them, the chronic unpredictable mild stress model (CUMS) is widely used in depression research. This modeling method is closer to the pathogenesis of depression and is currently a commonly used depression modeling method.

[0003] At present, the experimental method of CUMS is mainly as follows: first, the healthy mice of the same species are divided into an experimental group and a control group. The control group is not treated, and the mice in the experimental group are placed in a depression modeling device. Then, a stress stimulation program that can combine different types of stress stimulation in random order and time is used, and different basic parameters of stress stimulation are set. Then, random emergency stimulation is performed on the mice in the experimental group under the control of the stress stimulation program. After the stress stimulation is completed, both groups of mice are subjected to behavioral tests, including forced swimming test, tail suspension test, open field test, etc. to reflect the emotional state and motor ability of the mice. Finally, the results are combined to determine whether the mice are depressed, so as to explore the pathogenesis of depression.

[0004] At present, the depression modeling device used in the prior art generally uses a box of fixed volume as the experimental cage and then fixes each pre-determined emergency stimulus functional structure on the box to form a whole fixed device. However, since the device is an integral fixed device, it is impossible to flexibly add and replace new emergency stimulus functional structures to the device, resulting in few stimulation items, incomplete experiments, and the experimental cage cannot be replaced for compatibility and practicality under different models. A complete set of configuration is required, resulting in increased equipment costs. Because CUMS involves many types of stress and emphasizes "randomness", the CUMS operating procedures and experimental devices of each laboratory are almost different, which seriously affects the standardization of depression model construction and the accurate replication of depression models. In the behavioral test after stress stimulation, the tail clamping device lacks precise positioning and a firm clamping structure, which makes it impossible to stably complete the behavioral test, ultimately resulting in inaccurate experimental results. Summary of the invention

[0005] In view of this, the purpose of the present invention is to propose an automated integrated depression modeling device for rats and mice, by providing a depression modeling device for rats and mice that is equipped with a standardized emergency stimulation module, a module-adaptive basic experimental cage and a high-precision stable tail clamp, thereby solving the problem in the prior art that there is no standardized and flexible emergency stimulation function module and an experimental cage used with the module, resulting in the inability to replace the experimental cage under different models for compatibility and practicality and the inability to unify standards, as well as the inability to accurately and stably clamp the tail during behavioral testing, resulting in inaccurate experimental results or even experimental failure.

[0006] The present invention is achieved through the following technical solutions:

[0007] An automated integrated device for constructing a depression model for mice and rats is characterized in that it includes a spliced ​​basic experimental cage, a water control function part is fixedly arranged on the left side of the spliced ​​basic experimental cage, a precise mouse tail clamp function part is fixedly arranged on the right side of the spliced ​​basic experimental cage, a spliced ​​mouse activity board is connected to the middle of the spliced ​​basic experimental cage through an oscillating rotation mechanism, the left and right sides of the spliced ​​basic experimental cage are fixedly connected by an electric telescopic column, and a central controller is arranged on the outside of the spliced ​​basic experimental cage through a wireless signal connection.

[0008] Furthermore, the water control function part includes a water supply bottle, which is fixedly arranged on the outside of the left side wall of the splicing type basic experimental cage through a water supply bottle fixing part, and a control valve is provided on the water supply bottle fixing part. The input end of the control valve is connected with the output end of the water supply bottle, and the output end of the control valve is provided with a water supply pipe. The water supply bottle is connected with the interior of the splicing type basic experimental cage through the water supply pipe, and a water pumping and sewage discharge liquid storage tank is fixedly arranged below the water supply bottle, and a two-way water pump is fixedly arranged inside the water pumping and sewage discharge liquid storage tank, and the two-way water pump is connected with the interior of the splicing type basic experimental cage through a liquid flow pipe.

[0009] Furthermore, the precise mousetrap tail functional part includes an electric telescopic magnetic mousetrap rod and a flexible limit-position identification mousetrap device, the electric telescopic magnetic mousetrap rod is composed of an electric telescopic rod, a flexible fishing rope and a magnetic ring block, and the flexible limit-position identification mousetrap device is composed of a magnetic base, a surrounding clamp, a flexible pad and a position signal identifier fixedly arranged on the surface of the flexible pad.

[0010] Furthermore, the oscillating and rotating mechanism includes a left and right electric rotating sleeve fixedly arranged on the top of the spliced ​​basic experimental cage, an electric telescopic plate fixedly arranged on the bottom of the left and right electric rotating sleeve, a front and rear electric rotating sleeve fixedly arranged on the bottom of the electric telescopic plate, and the spliced ​​mouse activity plate fixedly arranged on the bottom of the front and rear electric rotating sleeve.

[0011] Furthermore, a temperature regulating device is fixedly provided at the rear end of the left side of the spliced ​​basic experimental cage, an LED light strip is fixedly provided on the right side of the temperature regulating device, and a feeding device is fixedly provided at the rear end of the right side of the spliced ​​basic experimental cage.

[0012] Furthermore, the spliced ​​basic experimental cage includes a left-side basic experimental cage and a right-side basic experimental cage, and the left-side basic experimental cage and the right-side basic experimental cage are sealed and connected by a sealing clamping part, and the sealing clamping part includes a sealing clamping inverted head and a sealing clamping guide groove, and the surfaces of the sealing clamping inverted head and the sealing clamping guide groove are provided with a sealing rubber coating, and the sizes of the sealing clamping inverted head and the sealing clamping guide groove match each other.

[0013] Furthermore, the spliced ​​basic experimental cage is provided with a position signal transmitter and a tail clamping magnetic ring for being worn on the experimental mouse.

[0014] Furthermore, the outer side walls of the spliced ​​basic experimental cage are made of intelligent dimming glass.

[0015] The beneficial effects of the present invention are:

[0016] The present invention provides a mouse and rat depression modeling device that is equipped with a standardized emergency stimulation module, a module-matching basic experimental cage, and a high-precision stable tail clamp. The modular structure that can be sealed and spliced ​​is combined with the existing basic experimental cage, which is conducive to the flexible addition and replacement of emergency stimulation function modules. The electric telescopic column is combined with the experimental cage with basic functions on the left and right sides of the foundation, so that the volume of the experimental cage can be changed by adjusting the length of the telescopic column at will, so that it can be compatible with the new insertion module. With a standardized emergency stimulation module, a basic experimental cage can be matched with a variety of different standard emergency stimulation modules to form convenient compatible replacement of different experimental projects. The combination of the position signal transmitter and the position signal identifier can ensure that the tail area is accurately identified when the tail is clamped, and with flexible and stable support, the tail can be clamped accurately and stably, thereby improving the accuracy of the experimental results. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is the appearance diagram of the overall structure of the assembly;

[0018] Figure 2 This is the internal structure diagram of the overall structure;

[0019] Figure 3 This is the front view of the internal structure of the overall structure;

[0020] Figure 4 It is a top view of the internal structure of the overall structure;

[0021] Figure 5 It is the rear view of the overall structure;

[0022] Figure 6 It is a card connection structure diagram;

[0023] Figure 7 To control the relationship diagram.

[0024] Description of reference numerals:

[0025] 1. Spliced ​​basic experimental cage; 2. Water supply bottle; 3. Water supply bottle fixings; 4. Control valve; 5. Water supply pipe; 6. Pumping and sewage storage tank; 7. Two-way water pump; 8. Liquid flow pipe; 9. Precision mousetrap tail function part; 10. Electric telescopic magnetic mousetrap rod; 11. Flexible limit recognition mousetrap device; 12. Electric telescopic rod; 13. Flexible fishing rope; 14. Magnetic ring block; 15. Magnetic base; 16. Surrounding claws; 17. Flexible pad; 18. Position signal identifier; 19. Position Signal transmitter; 20. Tail clamping magnetic ring; 21. Oscillating rotation mechanism; 22. Spliced ​​mouse activity board; 23. Left and right electric rotating sleeves; 24. Electric telescopic plate; 25. Front and rear electric rotating sleeves; 26. Electric telescopic column; 27. Left basic experimental cage; 28. Right basic experimental cage; 29. ​​Sealed clamping part; 30. Sealed clamping inverted head; 31. Sealed clamping guide groove; 32. Temperature regulating device; 33. LED light strip; 34. Feeding device; 35. Central controller. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0027] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0029] In the above description of the present invention, it should be noted that the terms "one side", "the other side", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of the invention is usually placed when in use, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0030] In addition, the term "same" does not mean that the parts must be absolutely the same, but slight differences are allowed. The term "vertical" only means that the positional relationship between the parts is more vertical than "parallel", and does not mean that the structure must be completely vertical, but can be slightly tilted.

[0031] like Figure 1-7 As shown, an embodiment of the present invention is: an automated integrated device for constructing a depression model for mice and rats, comprising a spliced ​​basic experimental cage 1, a water control function part is fixedly arranged on the left side of the spliced ​​basic experimental cage, the water control function part comprises a water supply bottle 2, the water supply bottle is fixedly arranged on the outside of the left side wall of the spliced ​​basic experimental cage through a water supply bottle fixing part 3, a control valve 4 is arranged on the water supply bottle fixing part, the input end of the control valve is connected with the output end of the water supply bottle, a water supply pipe 5 is arranged at the output end of the control valve, the water supply bottle is connected with the inside of the spliced ​​basic experimental cage through the water supply pipe, a water pumping and sewage storage tank 6 is fixedly arranged below the water supply bottle, and a two-way water pump 7 is fixedly arranged inside the water pumping and sewage storage tank, so that the inside of the spliced ​​basic experimental cage can be perfused with constant temperature water to enable the mice to complete the swimming experiment, and the residual waste liquid inside the spliced ​​basic experimental cage can be pumped out, wherein the two-way water pump is connected with the inside of the spliced ​​basic experimental cage through a liquid flow tube 8, so as to realize the above operation.

[0032] A precise mousetrap tail function part 9 is fixedly arranged on the right side of the spliced ​​basic experimental cage, and the precise mousetrap tail function part includes an electric telescopic magnetic mousetrap rod 10 and a flexible limit position identification mousetrap device 11, wherein the electric telescopic magnetic mousetrap rod is composed of an electric telescopic rod 12, a flexible fishing rope 13 and a magnetic ring block 14, and the flexible limit position identification mousetrap device is composed of a magnetic base 15, a surrounding clamping claw 16, a flexible pad 17 and a position signal identifier 18 fixedly arranged on the surface of the flexible pad. A position signal transmitter 19 and a tail clamping magnetic ring 20 for wearing on the experimental mouse are arranged inside the spliced ​​basic experimental cage, and the position signal transmitter cooperates with the position signal identifier, and the tail clamping magnetic ring is a permanent magnet. The position signal transmitter is a component worn around the waist of the mouse, and the tail clamping magnetic ring is fixedly connected to the position signal transmitter through a rope, and the tail clamping magnetic ring is firmly clamped and worn on the tail of the mouse.

[0033] A spliced ​​mouse activity board 22 is connected to the middle of the spliced ​​basic experimental cage through an oscillating and rotating mechanism 21. The oscillating and rotating mechanism includes a left and right electric rotating sleeve 23 fixedly arranged on the top of the spliced ​​basic experimental cage, an electric telescopic plate 24 is fixedly arranged at the bottom of the left and right electric rotating sleeves, and a front and rear electric rotating sleeve 25 is fixedly arranged at the bottom of the electric telescopic plate. The spliced ​​mouse activity board is fixedly arranged at the bottom of the front and rear electric rotating sleeves. This structure can realize the movement of the spliced ​​mouse activity board in various directions such as front and back, left and right, up and down through the cooperation of the left and right electric rotating sleeves, the electric telescopic plate and the front and rear electric rotating sleeves, and can also realize tilt oscillation by controlling different amplitudes.

[0034] The left and right sides of the spliced ​​basic experimental cage are fixedly connected by an electric telescopic column 26. The spliced ​​basic experimental cage includes a left basic experimental cage 27 and a right basic experimental cage 28. The left basic experimental cage and the right basic experimental cage are connected by a sealing clamping part 29. The sealing clamping part includes a sealing clamping inverted head 30 and a sealing clamping guide groove 31. The surface of the sealing clamping inverted head and the sealing clamping guide groove is provided with a sealing rubber coating, which is conducive to better sealing and tight assembly. The size of the sealing clamping inverted head and the sealing clamping guide groove matches. Therefore, when a new functional module needs to be added to the middle of the spliced ​​basic experimental cage, it is only necessary to extend the electric telescopic column to lengthen the main support of the spliced ​​basic experimental cage, and then the sealing clamping inverted head and the sealing clamping guide groove of the functional module to be added are respectively inserted into the sealing clamping inverted head and the sealing clamping guide groove of the original basic experimental cage, and then the electric telescopic column is retracted to drive it to be fastened and assembled to the main body of the spliced ​​basic experimental cage to achieve the addition of the new functional module. The spliced ​​mouse activity board inside the spliced ​​basic experimental cage is also connected to increase or decrease in this way.

[0035] A temperature regulating device 32 is fixedly installed at the rear end of the left basic experimental cage, an LED light strip 33 is fixedly installed at the right basic experimental cage, a feeding device 34 is fixedly installed at the right basic experimental cage, and a central controller 35 is installed outside the spliced ​​basic experimental cage through a wireless signal connection.

[0036] When implementing this embodiment, first, put the mice wearing the position signal transmitter and the magnetic ring on the tail into the spliced ​​basic experimental cage, and then start the experiment on the mice entering the spliced ​​basic experimental cage through the central controller. The control valve can be controlled to conduct a water deprivation experiment on the mice.

[0037] The central controller can also be used to control the pumping and sewage storage tank to cooperate with the two-way water pump to pump the liquid in the pumping and sewage storage tank into the spliced ​​basic experimental cage. The pumping and sewage storage tank is provided with a drainage hole at the bottom, and a temperature regulator is also provided inside, which is connected to the central controller to control the temperature of the cold water discharged into the spliced ​​basic experimental cage to 4°C. The central controller controls the oscillating rotation mechanism to put the mice into the pool for 5 minutes, and the rest of the conditions remain the same as normal breeding to achieve the cold water swimming experiment.

[0038] The central controller controls the combined movement of the left and right electric rotating sleeves, the electric telescopic plate, and the front and rear electric rotating sleeves, thereby adjusting the spliced ​​mouse activity board so that the board body tilts at an angle of 45° and maintains stimulation for 24 hours to complete the tilting experiment.

[0039] After the central controller issues the command to capture the suspended tail, the central controller will control the position signal identifier to sense the position signal sent by the mouse, and then control the electric telescopic rod in the electric telescopic magnetic mousetrap to extend and retract it to the position where the mouse position signal is sent, and then the central controller controls the rotating base at the bottom of the electric telescopic rod to rotate, thereby driving the electric telescopic rod to deflect, so that the flexible fishing line approaches the experimental mouse. At this time, the central controller is used to control the magnetic suction ring block to energize it to generate magnetism, and then the magnetic suction ring block will strongly absorb the tail clamping magnetic ring, thereby achieving the goal of capturing the mouse, and then the central controller controls the rotating base to rotate and the electric telescopic rod to retract, so as to suspend the mouse, and then set the corresponding suspension value to realize the suspension experiment.

[0040] The central controller controls the position signal sensor to sense the position signal emitted by the mouse, and then controls the electric telescopic magnetic mousetrap rod to complete the capture of the mouse as in the above process. Then, under the control of the central controller, the mouse is slowly pulled close to the flexible limit identification mousetrap device. In this process, due to the signal induction of the position signal identifier and the position signal transmitter, combined with the central controller, automatic slow approach can be achieved. When it is detected that the position signal emitted by the position signal transmitter on the mouse has entered the target area, the central controller controls the surrounding clamp to clamp the mouse's tail, and then controls the magnetic ring block to demagnetize, thereby releasing the grip on the mouse. Then the central controller turns on the magnetic base to give it a magnetic adsorption force to magnetically fix the mouse's tail, and once again ensures that the surrounding clamp firmly clamps the mouse's tail, thereby achieving the goal of flexibly capturing the mouse and accurately clamping the mouse's tail for firm fixation.

[0041] The temperature regulating device, LED light strip and feeding device can also be controlled separately by the central controller to conduct light and dark experiments, heat baking experiments and fasting experiments.

[0042] The above are all corresponding functional experiments carried out according to the functional modules. Other standardized functional modules can also be adopted according to the needs, and the method of inserting the spliced ​​basic experimental cage can realize standardized functional experiments under various functional conditions.

[0043] This embodiment provides a mouse and rat depression modeling device that is equipped with a standardized emergency stimulation module, a module-adaptable basic experimental cage, and a high-precision stable tail clamp. The modular structure that can be sealed and spliced ​​is combined with the existing basic experimental cage, which is conducive to the flexible addition and replacement of emergency stimulation function modules. The electric telescopic column is combined with the experimental cage with basic functions on the left and right sides of the foundation, so that the volume of the experimental cage can be changed by adjusting the length of the telescopic column at will, so that it can be compatible with the new insertion module. With a standardized emergency stimulation module, a basic experimental cage can be matched with a variety of different standard emergency stimulation modules to form convenient compatible replacement of different experimental projects. The combination of the position signal transmitter and the position signal identifier can ensure that the tail area is accurately identified when clamping the tail, and with flexible and stable support, the tail can be clamped accurately and stably, improving the accuracy of the experimental results.

[0044] In this embodiment, the outer side walls of the spliced ​​basic experimental cage are made of intelligent dimming glass, which is conducive to direct observation of the interior. When a dark experiment is required, the glass can be directly adjusted to pure black through the intelligent dimming glass, thereby forming a pure black space within the space for dark experiments.

[0045] In the present embodiment, a variety of standardized functional modules with other external environment adjustment functions (such as noise and electric shock, etc.) are used in conjunction with the spliced ​​basic experimental cage. The standardized functional modules are all provided with sealed snap-fit ​​inverted heads and sealed snap-fit ​​guide grooves on the left and right edges that match the sealed snap-fit ​​inverted heads and sealed snap-fit ​​guide grooves on the spliced ​​basic experimental cage. The external frames of these standardized functional modules can be assembled to the spliced ​​basic experimental cage in a sealing and fitting manner by snapping, thereby adding new experimental functions to the spliced ​​basic experimental cage in a standardized manner.

[0046] In this embodiment, an infrared monitor is fixedly installed inside the spliced ​​basic experimental cage, which is helpful for real-time monitoring and observation of the mice. In addition, the infrared monitor can also clearly observe the mice in the cage during dark experiments.

[0047] In this embodiment, a mouse entry door can be opened at any position on the top of the left basic experimental cage or the right basic experimental cage, or the mouse can be placed in the left basic experimental cage or the right basic experimental cage, and then the left basic experimental cage;

[0048] Press and splice it with the basic experimental cage on the right, so as to place the mice into the spliced ​​basic experimental cage for experiment.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the purpose and scope of the technical solution of the present invention, which should be included in the scope of the claims of the present invention.

Claims

1. Automated integrated construction of depression modeling device for rats and mice, Features: The invention comprises a spliced ​​basic experimental cage, wherein a water control function part is fixedly arranged on the left side of the spliced ​​basic experimental cage, a precise mouse tail clamp function part is fixedly arranged on the right side of the spliced ​​basic experimental cage, a spliced ​​mouse activity board is connected to the middle part of the spliced ​​basic experimental cage through an oscillating rotation mechanism, the left and right sides of the spliced ​​basic experimental cage are fixedly connected through an electric telescopic column, and a central controller is arranged on the outside of the spliced ​​basic experimental cage through a wireless signal connection.

2. The automated integrated device for constructing depression models in mice and rats according to claim 1, Features: The water control function part includes a water supply bottle, which is fixedly arranged on the outside of the left side wall of the spliced ​​basic experimental cage through a water supply bottle fixing part. A control valve is provided on the water supply bottle fixing part. The input end of the control valve is connected with the output end of the water supply bottle. The output end of the control valve is provided with a water supply pipe. The water supply bottle is connected with the interior of the spliced ​​basic experimental cage through the water supply pipe. A water pumping and sewage discharge liquid storage tank is fixedly arranged below the water supply bottle. A two-way water pump is fixedly arranged inside the water pumping and sewage discharge liquid storage tank. The two-way water pump is connected with the interior of the spliced ​​basic experimental cage through a liquid flow pipe.

3. The automated integrated device for constructing depression modeling in rats and mice according to claim 1, Features: The precise mousetrap tail functional part includes an electric telescopic magnetic mousetrap rod and a flexible limit-position identification mousetrap device. The electric telescopic magnetic mousetrap rod is composed of an electric telescopic rod, a flexible fishing rope and a magnetic ring block. The flexible limit-position identification mousetrap device is composed of a magnetic base, a surrounding clamping claw, a flexible pad and a position signal identifier fixedly arranged on the surface of the flexible pad.

4. The automated integrated device for constructing depression modeling in mice and rats according to claim 1, Features: The oscillating rotation mechanism includes a left and right electric rotating sleeve fixedly arranged on the top of the spliced ​​basic experimental cage, an electric telescopic plate fixedly arranged at the bottom of the left and right electric rotating sleeve, a front and rear electric rotating sleeve fixedly arranged at the bottom of the electric telescopic plate, and the spliced ​​mouse activity plate fixedly arranged at the bottom of the front and rear electric rotating sleeve.

5. The automated integrated device for constructing depression model for rats and mice according to claim 1, Features: A temperature regulating device is fixedly arranged at the rear end of the left side of the spliced ​​basic experimental cage, an LED light strip is fixedly arranged on the right side of the temperature regulating device, and a feeding device is fixedly arranged at the rear end of the right side of the spliced ​​basic experimental cage.

6. The automated integrated device for constructing depression models in mice and rats according to claim 1, Features: The spliced ​​basic experimental cage includes a left-side basic experimental cage and a right-side basic experimental cage, and the left-side basic experimental cage and the right-side basic experimental cage are connected by a sealing clamping part. The sealing clamping part includes a sealing clamping inverted head and a sealing clamping guide groove. The surfaces of the sealing clamping inverted head and the sealing clamping guide groove are provided with a sealing rubber coating, and the sizes of the sealing clamping inverted head and the sealing clamping guide groove match each other.

7. The automated integrated device for constructing depression models in mice and rats according to claim 1, Features The spliced ​​basic experimental cage is provided with a position signal transmitter and a tail clamping magnetic ring for wearing on the experimental mouse.

8. The automated integrated device for constructing depression models in mice and rats according to claim 1, Features The outer side walls of the spliced ​​basic experimental cage are made of intelligent dimming glass.

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