Sanitary insecticidal compound composition and application thereof

Abstract

The invention discloses a sanitary insecticidal compound composition and application thereof, the effective component of the compound insecticide is composed of an active component A and an active component B, the active component A is a piperic acid derivative compound, the active component B is an organophosphorus insecticide, and the organophosphorus insecticide is any one of dithiophosphos, fenthion, fenitrothion and pirimiphos-methyl. The total weight of the active component A and the organophosphorus insecticide accounts for 2-50% of the insecticidal composition, and the compounding weight ratio is (20: 1)-(1: 10). The binary composition solves the problem of resistance of sanitary pests to organophosphorus, improves the control effect, reduces the pesticide application amount, reduces the pesticide application irritation, and prolongs the persistence. The active component A is used as a lethal agent, has no cross resistance with organic phosphorus, has a good lethal effect, has no repellency to sanitary pests, is widely applied to places such as hotels, schools, factories and farms, and has a special effect on prevention and treatment of the sanitary pests.

Description

Technical Field

[0001] The invention relates to a sanitary insecticide compound composition, in particular to a sanitary insecticide composition containing an active component A and an active component B, wherein the active component A is selected from piperic acid derivative compounds, and the active component B is selected from any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos, and belongs to the technical field of sanitary insecticide. Background Art

[0002] In recent years, the field of residual spraying has seen pain points such as difficulty in completely killing mosquitoes and flies, short or no lasting effect of the pesticide, and other problems. When applying pesticides, the applicators can only increase the dosage and frequency of application, which leads to a significant increase in mosquito and fly resistance, a multiple increase in the cost of application, and an increase in the irritation of the pesticide to the applicators. Therefore, the market is in urgent need of a new generation of residual spraying agents to solve these pain points.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has contact and stomach poison activity and good conduction activity, can cause pests to become overexcited and convulse, causing them to die, has the characteristics of high efficiency, broad spectrum, and long lasting effect, and can be used to control a variety of Lepidoptera, Hemiptera, Thysanoptera, Coleoptera and other pests. The registered dosage form of compound I-72 has not yet been applied to sanitary pests. The structural formula of the compound is as follows:

[0004]

[0005] For a long time, organophosphorus insecticides have been widely used in the prevention and control of public health pests. The long-term use of these agents will inevitably make health pests such as mosquitoes, flies, cockroaches, etc. resistant to some organophosphorus agents, which will greatly reduce the control effect of the agents. Especially in southern China, the resistance increases rapidly, which greatly reduces the control effect of health pests.

[0006] To address this dilemma, we considered combining the new piperic acid derivative insecticide compound I-72 with organophosphorus insecticides. On the one hand, the two have different mechanisms of action and there is no cross-resistance when combined, which can solve the problem of organophosphorus resistance of sanitary pests and reduce the amount of pesticides applied. On the other hand, compound I-72 has low irritation, which improves the safety of pesticide applicators. Furthermore, research has found that combining the two can improve the control effect of sanitary pests, and is a combined drug application technology with good market prospects. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a sanitary insecticide compound composition and its application in view of the deficiencies in the prior art. The present invention compounds compound I-72 with organophosphorus to obtain a sanitary insecticide compound composition. The sanitary insecticide compound composition of the present invention has good insecticidal effect and low medication cost. The compound has synergistic effect, is not easy to produce drug resistance, and has a long lasting effect.

[0008] In order to achieve the above object, the present invention adopts the following technical solution:

[0009] The present invention first provides a sanitary insecticide compound composition, wherein the active ingredients are composed of active ingredient A and active ingredient B, the total weight of active ingredient A and active ingredient B accounts for 2% to 50% of the weight of the entire composition, and the remainder is auxiliary materials;

[0010] The active ingredient A is a piperic acid derivative compound represented by formula I (referred to as compound I-72);

[0011] The active ingredient B is an organophosphorus insecticide selected from any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos;

[0012]

[0013] In the above technical solution, the compounding weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:10, preferably 10:1 to 1:6.

[0014] In the above technical solution, the auxiliary material can be a mixture of any five or more of dispersant, wetting agent, defoamer, antifreeze, preservative, disintegrant, thickener, binder, attractant, stabilizer, filler and water in any proportion.

[0015] In the above technical solution, the sanitary insecticide compound composition is in the form of wettable powder, water dispersible granules, suspension or dry suspension.

[0016] In the above technical scheme, the sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 2%-50% of active ingredient, 1%-10% of dispersant, 1%-5% of wetting agent, 5%-10% of stabilizer, 5%-15% of attractant, and filler is supplemented to 100%.

[0017] In the above technical scheme, the sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10 disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

[0018] In the above technical scheme, the sanitary insecticide composition, when in the form of a suspension, comprises the following materials in weight percentage: 2%-50% of active ingredient, 1%-10% of dispersant, 1%-5% of wetting agent, 0.3%-0.5% of preservative, 0.5%-1.5% of thickener, 0.1-0.3% of defoaming agent, 3%-5% of antifreeze agent, 5%-10% of stabilizer, 5%-15% of attractant, and water is supplemented to 100%.

[0019] In the above scheme, the dispersant is selected from: any one of polycarboxylates (for example, TERSPERSE 2500, produced by Huntsman Corporation of the United States), lignin sulfonates, alkylbenzene sulfonates, naphthalenesulfonic acid formaldehyde condensate salts, alkylphenol polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, and glycerol fatty acid ester polyoxyethylene ethers, or a mixture of two or more of them in any proportion.

[0020] In the above scheme, the wetting agent is selected from: alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, Huntsman), naphthalene sulfonate (such as NNO), opening powder BX, wetting penetrant F, sodium dodecylbenzene sulfonate, detergent LS, any one of them, or a mixture of two or more in any proportion.

[0021] In the above scheme, the defoaming agent can be any one of polydimethylsiloxane, diethylene glycol ester, tributyl phosphate, and dipalmitoylethylenediamine, or a mixture of two or more of them in any proportion.

[0022] In the above scheme, the antifreeze agent can be any one of ethylene glycol, propylene glycol, glycerol, and urea, or a mixture of two or more of them in any proportion.

[0023] In the above scheme, the preservative is selected from any one of potassium sorbate and sodium benzoate or a mixture of the two in any proportion.

[0024] In the above scheme, the disintegrant is selected from: any one of ammonium sulfate, sodium sulfate, sodium bicarbonate, and sodium carbonate, or a mixture of two or more of them in any proportion.

[0025] In the above scheme, the thickener is selected from: any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of them in any proportion.

[0026] In the above technical solution, the stabilizer is selected from: any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and a mixture of two or more of them in any proportion. After the stabilizer is added to the composite composition, the lethality rate on the semi-absorbent surface or the absorbent surface within 30 days is greater than 60%.

[0027] In the above scheme, the binder is selected from: any one of dextrin, polyvinyl pyrrolidone, sodium alginate, or a mixture of two or more of them in any proportion.

[0028] In the above scheme, the attractant is selected from: any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, milk flavor, or a mixture of two or more in any proportion. After the attractant is added to the composite composition, the application area can be 20% to 40% of the conventional application area, and the application location is selected from the four corners of the indoor room wall, the top or bottom corner line.

[0029] In the above scheme, the filler is selected from: any one of kaolin, clay, diatomaceous earth, bentonite, white carbon black, attapulgite, corn starch, and light calcium carbonate, or a mixture of two or more of them in any proportion.

[0030] In the above technical scheme, when the sanitary insecticide composition is in the form of wettable powder, water dispersible granules, suspension concentrate or dry suspension concentrate, it can be prepared according to conventional methods or existing methods in the art.

[0031] The present invention also provides an application of the sanitary insecticide compound composition in preventing and controlling sanitary pests in application fields by local application.

[0032] In the above technical solution, the local application method refers to a residual spraying method or a brushing method.

[0033] In the above technical solution, the application fields include hotels, schools, factories, farms and other places.

[0034] In the above technical scheme, the sanitary pests refer to one or more of housefly, city fly, big-headed golden fly, silk-light green fly, copper green fly, bright green fly, summer toilet fly, original toilet fly, red-headed blowfly, and trap fly.

[0035] In the above technical scheme, when the sanitary insecticide composite composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on the surfaces of walls, floors, doors and windows, ceilings and homes in the application field, so that the sanitary pests are knocked down and killed when they contact the surface.

[0036] Compared with the existing technology, it has the following characteristics:

[0037] (1) The present invention has found through experiments that compound I-72 and some organophosphorus insecticides have a synergistic effect when combined. On the one hand, the environmental compatibility is good, which reduces the amount of pesticide used. On the other hand, from the perspective of the mechanism of action, compound I-72 has a different mechanism of action from organophosphorus sanitary insecticides and does not have cross-resistance, which solves the problem of sanitary pests' resistance to organophosphorus and improves the prevention effect. The combination of insecticides with different mechanisms of action can also delay pest resistance, which is beneficial to pest resistance control.

[0038] (2) In order to solve the problems of long-lasting efficacy and poor lethality to targets such as houseflies, we solved the problem of long-lasting efficacy through formulation technology. By studying the feeding habits of houseflies, we added attractants to increase the frequency of licking by houseflies, thereby increasing the amount of medicine ingested by houseflies; we also added stabilizers to increase the long-lasting effect of the composition, and the 30-day lethality rate was greater than 60%. DETAILED DESCRIPTION

[0039] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0040] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0041] The laboratory preparation method of wettable powder is: weigh the effective ingredient, wetting agent, dispersant, stabilizer, attractant and filler in proportion, add them into a mixer and mix them evenly, and then grind them with a jet mill to obtain the wettable powder.

[0042] The laboratory preparation method of water-dispersible granules is as follows: weigh the active ingredient, wetting agent, dispersant, attractant, disintegrant, stabilizer and filler in proportion, add them into a mixer and mix them evenly, grind them with a jet mill, use the mixer again, add water and a mixture of a binder, extrude and granulate them with a granulator, and dry them by boiling drying to obtain water-dispersible granules.

[0043] The laboratory preparation method of the suspension is: weigh water, dispersant, wetting agent, antifreeze, thickener, preservative, attractant, defoamer, and stabilizer in proportion, mix them evenly, add the effective ingredient, shear them with a high-speed shearing machine for 5 minutes, and then transfer them to a sand mill for sand grinding for 2-3 hours to control the particle size D90 below 5μm to obtain the suspension.

[0044] The present invention is described below in conjunction with specific embodiments:

[0045] Formulation Example 1: 20% Compound I-72·Dimethophos Wettable Powder

[0046] Compound I-72 10g, dimethoate 10g, sodium dodecylbenzene sulfonate 5g, calcium lignin sulfonate 10g, dimethyl disulfide 15g, urea-formaldehyde resin 5g, kaolin is supplemented to 100%.

[0047] Formulation Example 2: 30% Compound I-72·Dimethophos Water Dispersible Granules

[0048] Compound I-7220g, dimethoate 10g, lakai powder BX 0.5g, sodium dodecyl sulfate 0.5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 1g, ammonium sulfate 5g, dextrin 1g, polyalkylene glycol 5g, fatty acid dimethyl disulfide ester 5g, kaolin is supplemented to 100%.

[0049] Formulation Example 3: 15% Compound I-72·Dimethophos Suspension

[0050] Compound I-725g, dimethoate 10g, sodium hexadecyl sulfonate 0.5g, sodium dodecyl sulfate 0.5g, potassium polycarboxylate 1g, calcium lignin sulfonate 4g, potassium sorbate 0.5g, magnesium aluminum silicate 1g, xanthan gum 0.5g, polydimethylsiloxane 0.3g, propylene glycol 5g, polyacrylic acid 5g, tilapia meal 5g, and make up to 100% with water.

[0051] Formulation Example 4: 50% Compound I-72·Dimethophos Water Dispersible Granules

[0052] Compound I-7230g, dimethoate 20g, lakai powder BX 2g, sodium dodecyl sulfate 2g, sodium hexadecylbenzenesulfonate 2g, calcium lignin sulfonate 8g, ammonium sulfate 1g, sodium sulfate 3g, polyvinyl pyrrolidone 1g, ethylene oxide-propylene oxide block polyether 6g, brown sugar 12g, kaolin is supplemented to 100%.

[0053] Formulation Example 5: 2% Compound I-72·Dimethophos Suspension

[0054] Compound I-721g, dimethoate 1g, sodium dodecyl sulfate 0.5g, sodium hexadecyl sulfonate 0.5g, potassium polycarboxylate 0.5g, sodium naphthalenesulfonate formaldehyde condensate 0.5g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol 0.2g, ethylene glycol 4g, ethyl acrylate 6g, tilapia meal 5g, and make up to 100% with water.

[0055] Formulation Example 6: 14% Compound I-72·Fenthion Wettable Powder

[0056] Compound I-7212g, fenthion 2g, sodium lauryl sulfate 2g, calcium lignin sulfonate 6g, brown sugar 10g, vinyl acetate 6g, white carbon black 10g, diatomaceous earth is supplemented to 100%.

[0057] Formulation Example 7: 22% Compound I-72·Fenthion Water Dispersible Granules

[0058] Compound I-7220g, fenthion 2g, sodium dodecyl sulfate 3g, pull open powder BX 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium sulfate 5g, sodium bicarbonate 5g, polyvinyl pyrrolidone 0.5g, dextrin 0.5g, tetramethylpiperidinamine 7g, N-methylacetamide 10g, white carbon black 6g, kaolin is supplemented to 100%.

[0059] Formulation Example 8: 12% Compound I-72·Fenthion Suspension

[0060] Compound I-7210g, fenthion 2g, sodium hexadecyl sulfonate 2g, sodium dodecyl sulfate 1g, potassium polycarboxylate 4g, calcium lignin sulfonate 6g, potassium sorbate 0.5g, xanthan gum 0.5g, tributyl phosphate 0.3g, glycerol 3g, sodium alginate propylene glycol 7g, maltose 15g, water is supplemented to 100%.

[0061] Formulation Example 9: 15% Compound I-72·Fenthion Suspension

[0062] Compound I-7215g, dimethoate 5g, sodium lauryl sulfate 3g, polyoxyethylene fatty acid ester 1.5g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, tributyl phosphate 0.2g, dipalmitoyl ethylenediamine 0.1g, ethylene glycol 4g, methyl ethyl sulfonate 8g, honey 6g, water is supplemented to 100%.

[0063] Formulation Example 10: 18% Compound I-72·Fenthion Wettable Powder

[0064] Compound I-726g, fenthion 12g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate sodium salt 2g, naphthalenesulfonic acid sodium salt 2g, sodium dodecyl sulfate 1g, fatty acid dimethyl disulfide ester 5g, n-acylated alkyl alcohol amine 7g, attapulgite 10g, light calcium carbonate is supplemented to 100%.

[0065] Formulation Example 11: 50% Compound I-72·Fenthion Wettable Powder

[0066] Compound I-7225g, fenthion 25g, fatty alcohol polyoxyethylene ether 2g, lignin sulfonate calcium salt 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, phenethylphenol polyoxyethylene ether phosphate 2g, dimethyl disulfide 5g, milk flavor 10g, urea-formaldehyde resin 4g, polyalkylene glycol 4g, white carbon black 3g, diatomaceous earth is supplemented to 100%.

[0067] Formulation Example 12: 24% Compound I-72·Methylpirimiphos wettable powder

[0068] Compound I-7216g, methyl pirimiphos 8g, sodium dodecyl sulfate 0.5g, alkylbenzene polyoxyethylene ether phosphate 0.5g, lignin sulfonate calcium salt 6g, anisaldehyde 10g, N-methylacetamide 5g, n-acylated alkyl alcoholamine 9g, clay is supplemented to 100%.

[0069] Formulation Example 13: 40% Compound I-72·Methylpirimiphos Water Dispersible Granules

[0070] Compound I-7230g, methyl pirimiphos 10g, detergent LS 3g, sodium dodecyl sulfate 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, lignin sulfonate calcium salt 6g, sodium carbonate 5g, dextrin 1g, sodium alginate propylene glycol 8g, furanone 10g, bentonite 20g, corn starch is supplemented to 100%.

[0071] Formulation Example 14: 50% Compound I-72·Methylpirimiphos Suspension

[0072] Compound I-7240g, methyl pirimiphos 10g, sodium hexadecyl sulfonate 2g, wetting and penetrating agent F2g, glycerol fatty acid ester polyoxyethylene ether 1g, potassium polycarboxylate 4g, lignin sulfonate calcium salt 4g, sodium benzoate 0.3g, magnesium aluminum silicate 0.2g, methyl cellulose 0.3g, tributyl phosphate 0.1g, propylene glycol 5g, sodium alginate propylene glycol 9g, milk flavor 5g, water is supplemented to 100%.

[0073] Formulation Example 15: 16% Compound·Methyl Pirimiphos Water Dispersible Granules

[0074] Compound I-728g, methyl pirimiphos 8g, pull open powder BX 2g, sodium dodecyl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, lignin sulfonate calcium salt 5g, sodium sulfate 8g, sodium bicarbonate 2g, polyvinyl pyrrolidone 0.3g, sodium alginate 0.5g sodium alginate propylene glycol 9g, anisaldehyde 10g, clay 10g, kaolin is supplemented to 100%.

[0075] Formulation Example 16: 12% Compound I-72·Methylpirimiphos Suspension

[0076] Compound I-724g, methyl pirimiphos 8g, sodium lauryl sulfate 2g, alkylbenzene polyvinyl ether phosphate 2g, fatty amine polyoxyethylene ether 3g, polycarboxylic acid potassium salt 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, hydroxyethyl cellulose 0.3g, xanthan gum 0.2g, polydimethylsiloxane 0.3g, propylene glycol 4g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, honey 5g, water is supplemented to 100%.

[0077] Formulation Example 17: 30% Compound I-72·Methylpirimiphos wettable powder

[0078] Compound I-7215g, methyl pirimiphos 15g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, ligninsulfonic acid calcium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, N-methylacetamide 12g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol 5g, clay is supplemented to 100%.

[0079] Formulation Example 18: 12% Compound I-72·Fenthion Wettable Powder

[0080] Compound I-728g, 4g of chlorpyrifos, 2g of sodium lauryl sulfate, 1g of detergent LS, 5g of sodium naphthalenesulfonic acid formaldehyde condensate, 5g of calcium ligninsulfonate, 8g of N-methylacetamide, 7g of furanone, 5g of tetramethylpiperidinamine, and clay is added to 100%.

[0081] Formulation Example 19: 30% Compound I-72·Fenthion Water Dispersible Granules

[0082] Compound I-7225g, 5g of chlorpyrifos, 2g of phenethylphenol polyoxyethylene ether phosphate, 3g of sodium dodecyl sulfate, 3g of naphthalenesulfonic acid formaldehyde condensate sodium salt, 5g of ligninsulfonic acid calcium salt, 3g of sodium sulfate, 0.5g of sodium alginate, 5g of tetramethylpiperidinamine, 5g of sodium alginate propylene glycol ester, 8g of dimethyl disulfide, and kaolin is supplemented to 100%.

[0083] Formulation Example 20: 2% Compound I-72·Methylpirimiphos wettable powder

[0084] Compound I-721g, methyl pirimiphos 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, lignin sulfonate calcium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, N-methylacetamide 12g, sodium alginate propylene glycol 4g, tetramethylpiperidinamine 4g, clay is supplemented to 100%.

[0085] Formulation Example 21: 16% Compound I-72·Fenthion Suspension Concentrate

[0086] Compound I-728g, cypermethrin 8g, wetting and penetrating agent F 4g, fatty alcohol polyoxyethylene ether 1g, potassium polycarboxylate 4g, lignin sulfonate calcium salt 4g, sodium benzoate 0.5g, methyl cellulose 0.5g, polydimethylsiloxane 0.3g, urea 4g, sodium alginate propylene glycol 5g, N-methylacetamide 5g, water is supplemented to 100%.

[0087] Formulation Example 22: 45% Compound I-72·Fenthion Water Dispersible Granules

[0088] Compound I-7230g, 15g of chlorpyrifos, 3g of detergent LS, 1g of sodium dodecyl sulfate, 3g of sodium naphthalenesulfonic acid formaldehyde condensate, 6g of calcium ligninsulfonate, 5g of sodium sulfate, 0.1g of polyvinyl pyrrolidone, 5g of sodium alginate propylene glycol, 5g of dimethyl disulfide, and kaolin is supplemented to 100%.

[0089] Formulation Example 23: 18% Compound I-72·Fenthion Suspension Concentrate

[0090] Compound I-726g, 12g of cypermethrin, 2g of sodium lauryl sulfate, 4g of potassium polycarboxylate, 2g of sodium naphthalenesulfonate formaldehyde condensate, 0.5g of potassium sorbate, 1.2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.3g of diethylene glycol ester, 5g of propylene glycol, 5g of sodium alginate propylene glycol ester, 5g of n-acylated alkyl alcoholamine, 5g of milk flavor, and make up to 100% with water.

[0091] Formulation Example 24: 2% Compound I-72·Fenthion Water Dispersible Granules

[0092] Compound I-721g, fenthion 1g, sodium dodecyl sulfate 2g, pull open powder BX 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium sulfate 1g, sodium bicarbonate 2g, polyvinyl pyrrolidone 0.5g, dextrin 0.5g, n-acylated alkyl alcoholamine 5g, tetramethylpiperidinamine 5g, N-methylacetamide 5g, white carbon black 6g, kaolin is supplemented to 100%.

[0093] Formulation Example 25: 5% Compound I-72·Dimethophos Suspension

[0094] Compound I-724g, dimethoate 1g, sodium lauryl sulfate 3g, alkylphenol polyoxyethylene ether 1.5g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol ester 0.2g, ethylene glycol 2g, propylene glycol 3g, sodium alginate propylene glycol 5g, tilapia meal 6g, water is supplemented to 100%.

[0095] Application Example 1: Determination of the Co-toxicity Coefficient of Compound I-72 and Organophosphorus

[0096] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0097] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0098] Table 1 Determination of the co-toxicity coefficient of compound I-72 and dimethoate (for houseflies)

[0099]

[0100]

[0101] As shown in Table 1, when the compound I-72 and dimethoate are mixed in a ratio of 10:1 to 1:6, the co-toxicity coefficient against houseflies is greater than 120, and there is a synergistic effect, especially when the mixing ratio is 1:1, the synergistic effect is most obvious.

[0102] Table 2 Determination of the co-toxicity coefficient of compound I-72 and fenthion (for houseflies)

[0103]

[0104] As shown in Table 2, when the compound I-72 and fenthion were mixed in a ratio of 10:1 to 1:6, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the mixing ratio was 6:1, the synergistic effect was most obvious.

[0105] Table 3 Optimal co-toxicity coefficient of compound I-72 and other organophosphorus compounds (for houseflies)

[0106]

[0107] As can be seen from Table 3, the optimal ratios of compound I-72 and other organophosphorus compounds are all in the range of 10:1 to 1:6, which has a significant synergistic effect.

[0108] Application Example 2: Indoor efficacy test on three different surfaces for preventing and controlling mosquitoes and flies

[0109] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0110] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0111] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0112] Test surface: glass board, varnished wood board, gypsum board;

[0113] Dosage setting: The total concentration of active ingredients in the preparation examples is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0114] Control sample 1: prepared according to the formulation of Formulation Example 1 except for the stabilizer;

[0115] Control sample 2: prepared according to the formulation of Formulation Example 4 except for the stabilizer;

[0116] Control sample 3: prepared according to the formulation of Formulation Example 5 except for the stabilizer;

[0117] Commercial sample 1: 50% dimethoate EC (Jiangsu Gongcheng Biotechnology Co., Ltd.) diluted to 200 mg / l;

[0118] Commercial sample 2: 500 g / L pirimiphos-methyl emulsifiable concentrate (Syngenta Ltd., UK) diluted to 200 mg / L;

[0119] Test results:

[0120] Table 4: Efficacy test of formulation examples against mosquitoes and flies (glass plate)

[0121]

[0122]

[0123] Table 5: Efficacy test of formulation examples against mosquitoes and flies (varnished wooden board)

[0124]

[0125] Table 6: Efficacy test of formulation examples against mosquitoes and flies (gypsum board)

[0126]

[0127]

[0128] The test results show that when the dosage is reduced by half, the difference in efficacy between the drugs can be clearly seen on the glass surface. The efficacy of formulation examples 1, 4, 8, 11, 14, 17, and 20 are better than commercial samples 1 and 2 (see Table 4);

[0129] On semi-absorbent surface varnished wood boards and absorbent surface gypsum boards, the efficacy of the preparation examples decreased, mainly because part of the agent was absorbed by the material, resulting in less surface agent components. However, from the efficacy data, the preparation examples have good persistence, and the efficacy lethality of the varnish surface can reach more than 75% after 30 days, and the efficacy lethality of the gypsum surface can reach more than 60% after 30 days, which is better than the control samples 1, 2, 3 and the commercial samples 1 and 2. (See Table 5 and Table 6).

[0130] Application Example 3: Application of Appetite Inducing Agent in Preparation Example for Drug Efficacy Determination

[0131] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0132] Test method: Use a 1.2m*1.2**1.2m glass box, dilute the agent, soak it with 20cm*20cm filter paper, dry it and spread it on the glass box, put 30 houseflies in it, and observe the longest stay time and contact frequency of houseflies on the filter paper surface;

[0133] Test agents: Preparation Example 10, Preparation Example 20,

[0134] Control sample 4: prepared according to the formulation of formulation example 10 without milk flavor.

[0135] Control sample 5: prepared according to the formulation of formulation example 20 except for N-methylacetamide:

[0136] Dosage setting: The total concentration of active ingredients is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0137] Table 7 Effect of attractants on the efficacy of houseflies

[0138] name Maximum stay time Contact frequency (10min) KT50 24h mortality rate Preparation Example 10 15s 75 30.6min 86.7％ Control sample 4 7s 22 62.7min 70％ Preparation Example 20 25s 42 18.5min 100％ Control sample 5 8s 30 58.5min 73.3％

[0139] The test results show that the addition of milk flavor to Preparation Example 10 increases the frequency of houseflies contacting the agent, and the efficacy is relatively good; the addition of N-methylacetamide to Preparation Example 20 increases the residence time of houseflies on the filter paper surface, increases the frequency of houseflies licking, and causes houseflies to ingest more agents, so the final efficacy performance is better (see Table 7).

[0140] Application Example 4: Comparative Test on the Efficacy of Houseflies

[0141] Target: Housefly

[0142] Experimental method: Select the walls of the breeding farm building as the test objects and divide them into areas, spray the pesticide on the wall surface, and record the fly density reduction rate of each treatment group after 1 day, 2 days, and 3 days; the area of ​​the breeding farm room is about 50m2, and the area of ​​each wall is about 20m2.

[0143] Test treatment: Preparation examples 2, 9, 17, and 24 were diluted 100 times and sprayed on the four corners of the wall and the ground, accounting for 40% of the total area, with a dosage of 20 mg active ingredient / m2;

[0144] Control sample 6: Prepared according to the formulation of Preparation Example 2 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0145] Control sample 7: Prepared according to the formulation of Preparation Example 9 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0146] Control sample 8: Prepared according to the formulation of Preparation Example 17 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0147] Control sample 9: Prepared according to the formulation of Preparation Example 24 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0148] When applying the control samples 6, 7, 8, and 9, the pesticide was sprayed on the entire surface of the wall and the ground;

[0149] Table 8 Treatment of Formulation Examples 2, 9, 17, 24

[0150]

[0151]

[0152] Test results:

[0153] Table 9 Comparative test of the efficacy of formulation examples 2, 9, 17, and 24 against flies

[0154] deal with 1d density decrease rate 2d density decrease rate 3d density reduction rate Formulation Example 2 66.1％ 85.9％ 95.8％ Preparation Example 9 67.3％ 89.9％ 96.7％ Preparation Example 17 68.9％ 89.2％ 94.7％ Preparation Example 24 68.6％ 90.2％ 99.8％ Control sample 6 56.5％ 79.4％ 89.5％ Control sample 7 52.9％ 79.9％ 89.3％ Control sample 8 58.5％ 78.3％ 88.8％ Control sample 9 58.3％ 80.1％ 89.2％

[0155] As shown in Table 9, the present invention has strong attractant properties by adding attractant components, and converts conventional passive control into active attractant attraction. The application area is 20% and 40% of the conventional application area, and the application location is selected at the four corners of the wall. Formulation Examples 2, 9, 17, and 24 have obvious fly control effects, with a 1-day density reduction rate of more than 80%, and a 3-day density reduction rate of more than 94%, which are better than the control samples 6, 7, 8, and 9. Formulation Examples 2, 9, 17, and 24 add attractant components, and flies are killed after gathering around the attractant components and contacting the liquid; it can be seen that the compound I-72 and organophosphorus insecticide compound with the addition of attractant components has a better effect on controlling flies than the compound I-72 and organophosphorus insecticide compound without the addition of attractant components, and the dosage is less than that of the composition without the addition of attractant components.

[0156] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A sanitary insecticide composite composition, characterized in that: The active ingredients are composed of active component A and active component B, and the total weight of active component A and active component B accounts for 2% to 50% of the weight of the entire composition, and the remainder is excipients; The active component A is a piperic acid derivative compound shown in formula I; The active ingredient B is an organophosphorus insecticide selected from any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos; 2. The sanitary insecticide composite composition according to claim 1, characterized in that: The compounding weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:

10.

3. The sanitary insecticide composite composition according to claim 1, characterized in that: The sanitary insecticide composition is in the form of wettable powder, water-dispersible granules, and suspension; the auxiliary materials are a mixture of any five or more of dispersant, wetting agent, defoamer, antifreeze, preservative, disintegrant, thickener, binder, attractant, stabilizer, filler, and water in any proportion.

4. The sanitary insecticide composite composition according to claim 3, characterized in that: The sanitary insecticide compound composition, when in the form of a wettable powder, comprises the following raw materials in percentage by weight: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 5%-10% stabilizer, 5%-15% attractant, and filler to make up to 100%.

5. The sanitary insecticide composite composition according to claim 3, characterized in that: The sanitary insecticide compound composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10 disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

6. The sanitary insecticide composite composition according to claim 3, characterized in that: The sanitary insecticide compound composition, when in the form of a suspension, comprises the following materials in weight percentage: 2%-50% of active ingredients, 1%-10% of dispersants, 1%-5% of wetting agents, 0.3%-0.5% of preservatives, 0.5%-1.5% of thickeners, 0.1-0.3% of defoaming agents, 3%-5% of antifreeze agents, 5%-10% of stabilizers, 5%-15% of attractants, and water is added to 100%.

7. The sanitary insecticidal composition according to any one of claims 4 to 6, characterized in that: The attractant is selected from: any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, and milk flavor, or a mixture of two or more of them in any proportion.

8. The sanitary insecticide composition according to any one of claims 4 to 6, characterized in that: The stabilizer is selected from: any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and n-acylated alkyl alcohol amine, or a mixture of two or more in any proportion.

9. Use of the sanitary insecticide composite composition according to any one of claims 4 to 6 in controlling sanitary pests in an application field by topical application, characterized in that: The local application method refers to a residual spraying method or a brushing method; the application fields include hotels, schools, factories, farms and other places; the sanitary pests refer to one or more of houseflies, city flies, big-headed golden flies, silky green flies, copper green flies, bright green flies, summer toilet flies, toilet flies, red-headed blowflies, and ground flies.

10. The use according to claim 9, characterized in that: When the sanitary insecticide composite composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on the surfaces of walls, floors, doors and windows, ceilings and homes in the application field, so that the sanitary pests are knocked down and killed when they contact the surface.

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