Method, device and equipment for measuring QTc interval in flat movement test process

Abstract

The invention relates to a method, a device and equipment for measuring a QTc interval in a flat movement test process, a storage medium and a program product. The method comprises the steps of collecting electrocardiogram data according to a preset mode in a flat plate exercise test process; respectively determining a QRS wave group starting point and a T wave end point from the electrocardiogram data; determining a measured QT interval according to the QRS wave group starting point and the T wave end point; the measured QT interval is corrected for the first time through the time limit of the QRS wave group, and the corrected QT interval is obtained; automatically correcting the corrected QT interval for the second time according to the heart rate change of the testee in the tablet exercise test process to obtain a QTc interval; and drawing a real-time change trend chart of the QTc interval according to different stages of the flat plate motion test. Therefore, the QTc interval measurement of each stage in the plate motion test process can be automatically completed, the real-time measurement value of the QTc interval is obtained, the test efficiency is high, and the result is more accurate.

Description

Technical Field

[0001] The present application relates to the field of data processing technology, and in particular to a method, device, computer equipment, computer-readable storage medium and computer program product for measuring the QTc interval during a treadmill exercise test. Background Art

[0002] Long QT syndrome (LQTS) refers to a group of syndromes characterized by prolonged QT interval on the electrocardiogram, which is prone to malignant ventricular arrhythmias (especially torsade de pointes, TdP), syncope and sudden death. Treadmill exercise test equipment is of great significance in the diagnosis and risk stratification of LQTS patients. LQTS patients often show poor frequency adaptation, that is, after exercise, as the heart rate increases, the QTc interval (QT interval corrected for heart rate) prolongs more significantly.

[0003] At present, the treadmill exercise test examination equipment used in clinical applications needs to print a paper version of the electrocardiogram of the treadmill exercise process every 3 minutes, manually measure the QT interval through the split track, and then calculate the QTc interval through the heart rate correction formula.

[0004] However, this method requires high operator experience, and the manually calculated QTc interval has large errors and poor real-time performance. Summary of the invention

[0005] Based on this, it is necessary to provide a method, device, computer equipment, computer-readable storage medium and computer program product for measuring the QTc interval during a treadmill exercise test, which can automatically complete the entire measurement process and has high accuracy, in order to address the above technical problems.

[0006] In a first aspect, the present application provides a method for measuring the QTc interval during a treadmill exercise test, comprising:

[0007] During the treadmill exercise test, electrocardiogram data were collected according to the preset method;

[0008] From the electrocardiogram data, respectively determine the starting point of the QRS complex and the end point of the T wave;

[0009] Determine the measured QT interval according to the QRS complex start point and the T wave end point;

[0010] Performing a first correction on the measured QT interval by the duration of the QRS complex to obtain a corrected QT interval;

[0011] According to the change of the subject's heart rate during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval;

[0012] According to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval was drawn.

[0013] In one embodiment, during the treadmill exercise test, the electrocardiogram data is collected according to a preset method, including any of the following methods:

[0014] If manual measurement is adopted, at least three sinus rhythms are measured continuously, and the average value of the measured sinus rhythms is calculated to obtain the electrocardiogram data;

[0015] If the measurement is performed automatically, a target electrocardiogram device is selected to collect electrocardiogram data; the target electrocardiogram device includes any one of 12 leads, II leads, V2 leads, V5 leads, and V6 leads.

[0016] In one embodiment, determining the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data respectively includes:

[0017] Determining whether a double T wave peak appears in the electrocardiogram data;

[0018] If no T wave double peaks appear in the electrocardiogram data, the end point of the T wave is determined at the end position of the descending section of the first peak of the T wave;

[0019] If a double peak of T wave appears in the electrocardiogram data, determining whether the double peak of T wave overlaps with the U wave;

[0020] If the double peak of the T wave does not overlap with the U wave, the end point of the T wave is determined at the end of the descending segment of the second peak of the T wave;

[0021] If the double peak of the T wave overlaps with the U wave, and the amplitude of the U wave is lower than the isoelectric line, the end point of the T wave is determined at the end of the descending segment of the second peak of the T wave;

[0022] If the double peak of the T wave overlaps with the U wave, and the amplitude of the U wave is not lower than the isoelectric line, then start from the second peak of the T wave to find a tangent with the largest slope along the direction of the end of the T wave, and take the intersection of the tangent and the baseline as the end point of the T wave.

[0023] In one embodiment, determining whether a double T wave peak appears in the electrocardiogram data includes:

[0024] Obtaining the interval between two wave peaks that appear after the QRS wave group; if the interval is greater than a preset value, it is considered that no T wave double peaks appear; if the interval is not greater than a first preset value, it is considered that a T wave double peak appears;

[0025] The determining whether the T wave double peak and the U wave overlap comprises:

[0026] The notches of the two peaks that appear after the QRS complex are obtained. If the notches of the two peaks are both above the second preset value, it is considered that the T wave double peak does not overlap with the U wave; if the notch of one of the peaks is below the second preset value, it is considered that the T wave double peak overlaps with the U wave.

[0027] In one embodiment, the first correction of the measured QT interval by the duration of the QRS complex to obtain the corrected QT interval includes any of the following methods:

[0028] Method 1: subtracting a preset percentage of the QRS complex duration from the measured QT interval to obtain a corrected QT interval;

[0029] Method 2: Measure the interval from the end point of the QRS wave to the end point of the T wave to obtain the JT interval, and add the JT interval to the corresponding correction value according to different genders to obtain the corrected QT interval.

[0030] In one embodiment, the second correction of the corrected QT interval is automatically performed according to the change of the subject's heart rate during the treadmill exercise test to obtain the QTc interval, including:

[0031] If the heart rate of the subject during the treadmill exercise test is not greater than the third preset value, the corrected QT interval is corrected for the second time according to the square root of the RR interval to obtain the QTc interval;

[0032] If the heart rate of the subject during the treadmill exercise test is greater than the third preset value, the corrected QT interval is corrected for the second time according to the cube root of the RR interval to obtain the QTc interval.

[0033] In one embodiment, after drawing a real-time trend graph of the QTc interval according to different stages of the treadmill exercise test, the method further includes:

[0034] Extracting the maximum value of the QTc interval from the real-time change trend graph of the QTc interval;

[0035] The maximum value of the QTc interval is fed back to the test terminal.

[0036] In a second aspect, the present application also provides a device for measuring the QTc interval during a treadmill exercise test, comprising:

[0037] The acquisition module is used to collect electrocardiogram data according to a preset method during the treadmill exercise test;

[0038] A determination module, used to determine the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data;

[0039] A QT interval measurement module, used to determine the measured QT interval according to the starting point of the QRS complex and the end point of the T wave;

[0040] A first correction module, used for performing a first correction on the measured QT interval by the time limit of the QRS complex to obtain a corrected QT interval;

[0041] A second correction module is used to automatically perform a second correction on the corrected QT interval according to the heart rate change of the subject during the treadmill exercise test to obtain a QTc interval;

[0042] The trend graph drawing module is used to draw a real-time change trend graph of the QTc interval according to different stages of the treadmill exercise test.

[0043] In a third aspect, the present application further provides a computer device, including a memory and a processor, wherein the memory stores a computer program, and when the processor executes the computer program, the following steps are implemented:

[0044] During the treadmill exercise test, electrocardiogram data were collected according to the preset method;

[0045] From the electrocardiogram data, respectively determine the starting point of the QRS complex and the end point of the T wave;

[0046] Determine the measured QT interval according to the QRS complex start point and the T wave end point;

[0047] Performing a first correction on the measured QT interval by the duration of the QRS complex to obtain a corrected QT interval;

[0048] According to the change of the subject's heart rate during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval;

[0049] According to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval was drawn.

[0050] In a fourth aspect, the present application further provides a computer-readable storage medium having a computer program stored thereon, wherein when the computer program is executed by a processor, the following steps are implemented:

[0051] During the treadmill exercise test, electrocardiogram data were collected according to the preset method;

[0052] From the electrocardiogram data, respectively determine the starting point of the QRS complex and the end point of the T wave;

[0053] Determine the measured QT interval according to the QRS complex start point and the T wave end point;

[0054] Performing a first correction on the measured QT interval by the duration of the QRS complex to obtain a corrected QT interval;

[0055] According to the change of the subject's heart rate during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval;

[0056] According to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval was drawn.

[0057] In a fifth aspect, the present application further provides a computer program product, including a computer program, which implements the following steps when executed by a processor:

[0058] During the treadmill exercise test, electrocardiogram data were collected according to the preset method;

[0059] From the electrocardiogram data, respectively determine the starting point of the QRS complex and the end point of the T wave;

[0060] Determine the measured QT interval according to the QRS complex start point and the T wave end point;

[0061] Performing a first correction on the measured QT interval by the duration of the QRS complex to obtain a corrected QT interval;

[0062] According to the change of the subject's heart rate during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval;

[0063] According to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval was drawn.

[0064] The above-mentioned QTc interval measurement method, device, computer equipment, computer-readable storage medium and computer program product during the treadmill exercise test collect electrocardiogram data according to a preset method during the treadmill exercise test; thereby, electrocardiogram data containing a clear QRS wave group starting point and T wave peak can be obtained. From the electrocardiogram data, the QRS wave group starting point and the T wave end point are determined respectively; thereby, the measured QT interval can be determined according to the QRS wave group starting point and the T wave end point. The measured QT interval is first corrected by the time limit of the QRS wave group to obtain the corrected QT interval; thereby, the QT interval measurement error caused by bundle branch block can be eliminated, making the measurement result more accurate. According to the heart rate change of the subject during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval; thereby, the measurement interference caused by the absolute unequal RR interval of atrial fibrillation patients can be corrected, making the measurement result more accurate. According to the different stages of the treadmill exercise test, a real-time change trend chart of the QTc interval is drawn. Therefore, the QTc interval measurement at each stage of the treadmill exercise test can be automatically completed, and the real-time measurement value of the QTc interval can be obtained, with high test efficiency and more accurate results. BRIEF DESCRIPTION OF THE DRAWINGS

[0065] In order to more clearly illustrate the technical solutions in the embodiments of the present application or related technologies, the drawings required for use in the embodiments of the present application or related technical descriptions will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0066] Figure 1 is a schematic diagram of electrocardiogram measurement results in one embodiment;

[0067] Figure 2 A schematic diagram of a process for measuring the QTc interval during a treadmill exercise test in one embodiment;

[0068] Figure 3 A schematic diagram of a process for measuring the QTc interval during a treadmill exercise test in another embodiment;

[0069] Figure 4 A structural block diagram of a device for measuring the QTc interval during a treadmill exercise test in one embodiment;

[0070] Figure 5 A structural block diagram of a device for measuring the QTc interval during a treadmill exercise test in one embodiment;

[0071] Figure 6 FIG. 4 is a diagram showing the internal structure of a computer device in one embodiment. DETAILED DESCRIPTION

[0072] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0073] Figure 1 FIG. 1 is a schematic diagram of an electrocardiogram measurement result in an embodiment, Figure 1 As shown in the figure, general hospitals use 12-lead ECG monitoring methods to monitor heart patients, that is, 12 ECG data from different positions of the body are collected at the same time, and each heartbeat is a heartbeat, that is, an ECG cycle. An ECG cycle is composed of the main waveforms of P wave, QRS complex (Q wave, R wave, S wave), T wave, and U wave. Doctors need to find the position changes of abnormal waveforms in abnormal cycles during ECG reading, and then roughly calculate the PR interval (from the starting point of the P wave to the starting point of the QRS complex), QT interval (from the starting point of the QRS complex to the end point of the T wave), heart rate, etc. by manual calculation. Treadmill exercise test is of great significance in the diagnosis and risk stratification of LQTS patients. The treadmill exercise test equipment currently used in clinical practice needs to print a paper version of the ECG of the treadmill exercise process every 3 minutes, manually measure the QT interval through the split track, and then calculate the QTc interval through the heart rate correction formula. This method has large errors and cannot measure the QT interval in real time or calculate the QTc interval after correcting the heart rate. In view of the defects of the prior art, the present application provides a device that can collect electrocardiogram data according to a preset method during a treadmill exercise test; determine the starting point of the QRS wave group and the end point of the T wave from the electrocardiogram data; determine the measured QT interval according to the starting point of the QRS wave group and the end point of the T wave; perform a first correction on the measured QT interval by the time limit of the QRS wave group to obtain a corrected QT interval; automatically perform a second correction on the corrected QT interval according to the heart rate change of the subject during the treadmill exercise test to obtain a QTc interval; and draw a real-time change trend chart of the QTc interval (QT interval corrected for heart rate) according to different stages of the treadmill exercise test. In this way, the QTc interval measurement at each stage of the treadmill exercise test can be automatically completed to obtain a real-time measurement value of the QTc interval.

[0074] In an exemplary embodiment, Figure 2 As shown, a method for measuring the QTc interval during a treadmill exercise test is provided, and the method may include the following steps 201 to 206. Among them:

[0075] Step 201, during the treadmill exercise test, electrocardiogram data is collected according to a preset method.

[0076] In this embodiment, it is necessary to select a suitable lead for collecting electrocardiogram data. For example, the lead with the longest QT interval can be selected for measurement. The QT interval refers to the time limit from the start of the QRS complex to the end of the T wave, that is, the time from the start of ventricular depolarization to the end of ventricular repolarization, which represents the total time required from the start of ventricular muscle depolarization to the end of repolarization.

[0077] Exemplarily, if manual measurement is adopted, at least three sinus rhythms are measured continuously, and the average value of the measured sinus rhythms is calculated to obtain the electrocardiogram data.

[0078] Exemplarily, if the automatic measurement is adopted, a target electrocardiogram device is selected to collect electrocardiogram data; the target electrocardiogram device includes: any one of 12 leads, II leads, V2 leads, V5 leads, and V6 leads. When the automatic measurement is adopted, the appropriate lead is selected according to whether the starting point of the QRS complex is clear and the ST-T morphology.

[0079] Optionally, a standard 12-lead ECG is selected with a T wave amplitude ≥ 2 mm (millimeter) to make the T wave endpoint easier to discern.

[0080] Step 202, determining the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data.

[0081] In this embodiment, combined with Figure 1 As shown in Figure 1, the time period from the start of the QRS complex to the end of the T wave is defined as the QT interval. Since the QRS complex is significantly different from other waves, the start of the QRS complex is usually easy to identify. Therefore, it is important to be able to quickly and accurately identify the end of the T wave.

[0082] For example, the standard 12-lead ECG paper feed speed is 25mm / s and the amplitude is 10mm / mV (millimeter / millivolt). An increase in the paper feed speed (such as 50mm / s, millimeters per second) may deform the low-amplitude U wave. The starting point of the QRS wave is usually easy to identify, but the end point of the T wave is sometimes difficult to identify, especially when the T wave amplitude is low or the T wave and U wave are deformed when the drug causes QT interval prolongation. When the T wave end point is difficult to identify (for example, T wave bidirectional or notched, T-U wave overlap, etc.), it is also necessary to distinguish between T wave double peaks and T wave and U wave overlap.

[0083] Exemplarily, first determine whether a double T wave peak appears in the electrocardiogram data; if no double T wave peak appears in the electrocardiogram data, determine the end point of the T wave at the end of the descending section of the first peak of the T wave; if a double T wave peak appears in the electrocardiogram data, determine whether the double T wave peak overlaps with the U wave; if the double T wave peak does not overlap with the U wave, determine the end point of the T wave at the end of the descending section of the second peak of the T wave; if the double T wave peak overlaps with the U wave, and the amplitude of the U wave is lower than the isoelectric line, determine the end point of the T wave at the end of the descending section of the second peak of the T wave; if the double T wave peak overlaps with the U wave, and the amplitude of the U wave is not lower than the isoelectric line, start from the second peak of the T wave and search for a tangent with the largest slope along the direction of the end of the T wave, and take the intersection of the tangent and the baseline as the end point of the T wave.

[0084] In this embodiment, when there are double peaks of T waves, the second peak of T waves is easily mistaken for U waves, but T waves rarely show double peaks in lead 12, so the T wave endpoint can be directly determined in the lead without double peaks of T waves (such as aVL lead). When measuring with lead II, aVL lead, and aVR lead, since the amplitude of U waves is low, even lower than the isoelectric line, the T wave endpoint can also be determined more accurately.

[0085] Exemplarily, determining whether a T wave double peak appears in the electrocardiogram data may include: obtaining the interval between two peaks that appear after the QRS complex; if the interval is greater than a preset value, it is considered that a T wave double peak does not appear; if the interval is not greater than a first preset value, it is considered that a T wave double peak appears.

[0086] In this embodiment, the interval between the double peaks of the T wave is often less than 170 ms (some scholars believe that it is less than 150 ms, milliseconds). If the interval between the double peaks of the T wave is not greater than 150 ms, it is considered that a double peak of the T wave occurs.

[0087] Exemplarily, determining whether the T wave double peak and the U wave overlap may include: obtaining the notches of the two peaks that appear after the QRS complex; if the notches of the two peaks are both above a second preset value, it is considered that the T wave double peak and the U wave do not overlap; if the notch of one of the peaks is below the second preset value, it is considered that the T wave double peak and the U wave overlap.

[0088] In this embodiment, if the interval of the double peak of the T wave is greater than 150ms, the T wave and the U wave are considered to overlap. Optionally, since the notch of the double peak of the T wave (the notch refers to the pause that appears in the continuous cardiac line segment) is often above the baseline 2mm, and the height of the junction of T and U is often below the baseline 2mm, when the notch of both peaks is greater than 2mm, it is considered that the double peak of the T wave does not overlap with the U wave. If the notch of one of the peaks is not greater than 2mm, it is considered that the double peak of the T wave overlaps with the U wave.

[0089] Exemplarily, the T wave endpoint can also be determined by the tangent method. For example, a tangent is drawn from the T wave apex along the steepest point (the point with the largest slope) of the T wave terminal, and the intersection of the tangent and the baseline is defined as the T wave endpoint. When the T wave morphology is bimodal and the amplitude is similar, the QT interval is the time period from the start of the QRS wave to the intersection of the maximum tangent of the second peak of the T wave and the baseline.

[0090] Step 203, determining the measured QT interval according to the starting point of the QRS complex and the end point of the T wave.

[0091] In this embodiment, after the start point of the QRS complex and the end point of the T wave are determined, the start point of the QRS complex is subtracted from the end point of the T wave to obtain the measured QT interval.

[0092] Step 204, performing a first correction on the measured QT interval using the duration of the QRS complex to obtain a corrected QT interval.

[0093] In this embodiment, when measuring the QT interval, the following special situations may occur:

[0094] 1) Bundle branch block: When bundle branch block causes QRS wave widening, the QT interval may also be prolonged. This QT interval prolongation does not indicate abnormal ventricular repolarization, but is due to abnormal depolarization. At this time, the measured QT interval needs to be corrected for the first time.

[0095] Exemplary methods include any of the following:

[0096] Method 1: subtracting a preset percentage of the QRS complex duration from the measured QT interval to obtain a corrected QT interval;

[0097] Method 2: Measure the interval from the end of the QRS wave to the end of the T wave to obtain the JT interval (see Figure 1 As shown, it refers to the time segment from the J point to the end point of the T wave), and according to different genders, the JT interval is added to the corresponding correction value to obtain the corrected QT interval.

[0098] Exemplarily, when using method 1, the actual value of the QT interval (corrected QT interval) can be set to be equal to the measured value of the QT interval minus 48.5% of the QRS complex duration.

[0099] Exemplarily, measuring the JT interval can eliminate the influence caused by the widening of the QRS complex and correct the heart rate. For example, let the actual QTc value = JTc (JT interval after correcting the heart rate) + 95ms (male) or 88ms (female).

[0100] Step 205, automatically performing a second correction on the corrected QT interval according to the change in the subject's heart rate during the treadmill exercise test to obtain the QTc interval.

[0101] In this embodiment, if the subject's heart rate during the treadmill exercise test is not greater than the third preset value, the corrected QT interval is corrected for the second time according to the square root of the RR interval to obtain the QTc interval; if the subject's heart rate during the treadmill exercise test is greater than the third preset value, the corrected QT interval is corrected for the second time according to the cube root of the RR interval to obtain the QTc interval.

[0102] In this embodiment, the RR interval refers to the time between two R waves on the electrocardiogram. The normal RR interval should be between 0.6 and 1.0 seconds. A time less than 0.6 seconds indicates tachycardia, and a time greater than 1.0 seconds indicates bradycardia. The RR intervals of patients with atrial fibrillation are definitely different, so the longest and shortest RR intervals can be used to calculate QTc respectively and then take the average value, which is used as the final QTc interval.

[0103] For example, the definition of QTc interval: the normal QT interval shortens as the heart rate increases, so the determination of whether the QT interval is prolonged should be determined according to the heart rate. In clinical practice, the QTc interval is often used instead of the QT interval as an indicator for evaluating ventricular repolarization and depolarization, and the prolongation of the QTc interval is closely related to the occurrence of sudden cardiac death (SCD).

[0104] Exemplarily, during a treadmill exercise test, when the heart rate is no more than 100 beats / minute, the QTc calculation formula is: When the heart rate is too fast (especially >100 beats / min), the QTc interval calculated by the above formula is overestimated.

[0105] Step 206, drawing a real-time change trend graph of the QTc interval according to different stages of the treadmill exercise test.

[0106] In this embodiment, drawing the treadmill exercise test includes: an exercise phase and a recovery phase, and drawing real-time QTc interval change trend graphs in the exercise phase and the recovery phase respectively.

[0107] The above-mentioned QTc interval measurement method, device, computer equipment, computer-readable storage medium and computer program product during the treadmill exercise test collect electrocardiogram data according to a preset method during the treadmill exercise test; thereby, electrocardiogram data containing a clear QRS wave group starting point and T wave peak can be obtained. From the electrocardiogram data, the QRS wave group starting point and the T wave end point are determined respectively; thereby, the measured QT interval can be determined according to the QRS wave group starting point and the T wave end point. The measured QT interval is first corrected by the time limit of the QRS wave group to obtain the corrected QT interval; thereby, the QT interval measurement error caused by bundle branch block can be eliminated, making the measurement result more accurate. According to the heart rate change of the subject during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval; thereby, the measurement interference caused by the absolute unequal RR interval of atrial fibrillation patients can be corrected, making the measurement result more accurate. According to the different stages of the treadmill exercise test, a real-time change trend chart of the QTc interval is drawn. Therefore, the QTc interval measurement at each stage of the treadmill exercise test can be automatically completed, and the real-time measurement value of the QTc interval can be obtained, with high test efficiency and more accurate results.

[0108] In another exemplary embodiment, Figure 3 As shown, a method for measuring the QTc interval during a treadmill exercise test is provided, and the method may include the following steps 301 to 307. Among them:

[0109] Step 301, during the treadmill exercise test, electrocardiogram data is collected according to a preset method.

[0110] Step 302, determining the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data.

[0111] Step 303, determining the measured QT interval according to the starting point of the QRS complex and the end point of the T wave.

[0112] Step 304, performing a first correction on the measured QT interval using the duration of the QRS complex to obtain a corrected QT interval.

[0113] Step 305, automatically performing a second correction on the corrected QT interval according to the change in the subject's heart rate during the treadmill exercise test to obtain the QTc interval.

[0114] Step 306, drawing a real-time change trend graph of the QTc interval according to different stages of the treadmill exercise test.

[0115] For the specific implementation process and technical effects of steps 301 to 306 in this embodiment, please refer to Figure 2 The detailed description of steps 201 to 206 will not be repeated here.

[0116] Step 306: extract the maximum value of the QTc interval from the real-time change trend graph of the QTc interval.

[0117] In this embodiment, a real-time variation trend graph of the QTc interval at different stages of the treadmill exercise test is automatically generated, and the maximum value in each stage of the real-time variation trend graph of the QTc interval is obtained.

[0118] Step 307: Feedback the maximum value of the QTc interval to the test terminal.

[0119] In this embodiment, after the maximum value of the QTc interval is obtained, it is fed back to the test terminal, which can be a medical device or a target terminal where an embedded application is installed (for example, a personal computer, an image processing device, a mobile phone, etc.).

[0120] In this embodiment, by extracting the maximum value of the QTc interval from the real-time change trend diagram of the QTc interval and feeding back the maximum value of the QTc interval to the test terminal, it is not necessary for primary care physicians to manually calculate the QTc interval, the test accuracy is higher, and the efficiency of obtaining test data is greatly improved. In addition, the experience requirements for medical staff are greatly reduced, which is conducive to primary care physicians or non-arrhythmia physicians to quickly obtain QTc interval data.

[0121] It should be understood that, although the various steps in the flowcharts involved in the above-mentioned embodiments are displayed in sequence according to the indication of the arrows, these steps are not necessarily executed in sequence according to the order indicated by the arrows. Unless there is a clear explanation in this article, the execution of these steps does not have a strict order restriction, and these steps can be executed in other orders. Moreover, at least a part of the steps in the flowcharts involved in the above-mentioned embodiments can include multiple steps or multiple stages, and these steps or stages are not necessarily executed at the same time, but can be executed at different times, and the execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a part of the steps or stages in other steps.

[0122] Based on the same inventive concept, the embodiment of the present application also provides a device for measuring the QTc interval during a treadmill exercise test for realizing the method for measuring the QTc interval during a treadmill exercise test involved above. The implementation scheme for solving the problem provided by the device is similar to the implementation scheme recorded in the above method, so the specific limitations in the embodiments of the device for measuring the QTc interval during a treadmill exercise test provided below can refer to the limitations of the method for measuring the QTc interval during a treadmill exercise test above, and will not be repeated here.

[0123] In an exemplary embodiment, Figure 4 As shown, a device for measuring the QTc interval during a treadmill exercise test is provided, comprising: an acquisition module 401, a determination module 402, a QT interval measurement module 403, a first correction module 404, a second correction module 405 and a trend graph drawing module 406, wherein:

[0124] The acquisition module 401 is used to acquire electrocardiogram data according to a preset method during the treadmill exercise test;

[0125] A determination module 402, for determining the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data;

[0126] A QT interval measurement module 403, used to determine the measured QT interval according to the QRS complex start point and the T wave end point;

[0127] A first correction module 404 is used to perform a first correction on the measured QT interval according to the time limit of the QRS complex to obtain a corrected QT interval;

[0128] The second correction module 405 is used to automatically perform a second correction on the corrected QT interval according to the heart rate change of the subject during the treadmill exercise test to obtain the QTc interval;

[0129] The trend graph drawing module 406 is used to draw a real-time change trend graph of the QTc interval according to different stages of the treadmill exercise test.

[0130] Exemplarily, the acquisition module 401 is specifically used to: if the measurement is performed manually, at least three sinus rhythms are measured continuously, and an average value of the measured sinus rhythms is calculated to obtain electrocardiogram data;

[0131] If the measurement is performed automatically, a target electrocardiogram device is selected to collect electrocardiogram data; the target electrocardiogram device includes any one of 12 leads, II leads, V2 leads, V5 leads, and V6 leads.

[0132] Exemplarily, the determination module 402 is specifically used to: determine whether a double peak of T wave appears in the electrocardiogram data;

[0133] If no T wave double peaks appear in the electrocardiogram data, the end point of the T wave is determined at the end position of the descending section of the first peak of the T wave;

[0134] If a double peak of T wave appears in the electrocardiogram data, determining whether the double peak of T wave overlaps with the U wave;

[0135] If the double peak of the T wave does not overlap with the U wave, the end point of the T wave is determined at the end of the descending segment of the second peak of the T wave;

[0136] If the double peak of the T wave overlaps with the U wave, and the amplitude of the U wave is lower than the isoelectric line, the end point of the T wave is determined at the end of the descending segment of the second peak of the T wave;

[0137] If the double peak of the T wave overlaps with the U wave, and the amplitude of the U wave is not lower than the isoelectric line, then start from the second peak of the T wave to find a tangent with the largest slope along the direction of the end of the T wave, and take the intersection of the tangent and the baseline as the end point of the T wave.

[0138] Exemplarily, the determining whether a double T wave peak appears in the electrocardiogram data includes:

[0139] Obtaining the interval between two wave peaks that appear after the QRS wave group; if the interval is greater than a preset value, it is considered that no T wave double peaks appear; if the interval is not greater than a first preset value, it is considered that a T wave double peak appears;

[0140] The determining whether the T wave double peak and the U wave overlap comprises:

[0141] The notches of the two peaks that appear after the QRS complex are obtained. If the notches of the two peaks are both above the second preset value, it is considered that the T wave double peak does not overlap with the U wave; if the notch of one of the peaks is below the second preset value, it is considered that the T wave double peak overlaps with the U wave.

[0142] Exemplarily, the first correction module 404 is specifically configured to perform any of the following methods:

[0143] Method 1: subtracting a preset percentage of the QRS complex duration from the measured QT interval to obtain a corrected QT interval;

[0144] Method 2: Measure the interval from the end point of the QRS wave to the end point of the T wave to obtain the JT interval, and add the JT interval to the corresponding correction value according to different genders to obtain the corrected QT interval.

[0145] Exemplarily, the second correction module 405 is specifically used to: if the heart rate of the subject during the treadmill exercise test is not greater than the third preset value, perform a second correction on the corrected QT interval according to the square root of the RR interval to obtain the QTc interval;

[0146] If the heart rate of the subject during the treadmill exercise test is greater than the third preset value, the corrected QT interval is corrected for the second time according to the cube root of the RR interval to obtain the QTc interval.

[0147] In this embodiment, electrocardiogram data is collected according to a preset method during the treadmill exercise test; thus, electrocardiogram data containing a clear QRS wave group starting point and T wave peak can be obtained. From the electrocardiogram data, the QRS wave group starting point and T wave end point are determined respectively; thus, the measured QT interval can be determined according to the QRS wave group starting point and T wave end point. The measured QT interval is first corrected by the time limit of the QRS wave group to obtain the corrected QT interval; thus, the QT interval measurement error caused by bundle branch block can be eliminated, making the measurement result more accurate. According to the heart rate change of the subject during the treadmill exercise test, the corrected QT interval is automatically corrected for the second time to obtain the QTc interval; thus, the measurement interference caused by the absolute unequal RR interval of atrial fibrillation patients can be corrected, making the measurement result more accurate. According to the different stages of the treadmill exercise test, a real-time change trend chart of the QTc interval is drawn. Thus, the QTc interval measurement at each stage during the treadmill exercise test can be automatically completed, and the real-time measurement value of the QTc interval can be obtained, the test efficiency is high, and the result is more accurate.

[0148] In another exemplary embodiment, Figure 5 As shown, a device for measuring the QTc interval during a treadmill exercise test is provided. Figure 4 Based on the device shown, it can also include: a maximum value extraction module 407, which is used to extract the maximum value of the QTc interval from the real-time change trend diagram of the QTc interval; and feed back the maximum value of the QTc interval to the test terminal.

[0149] In this embodiment, by extracting the maximum value of the QTc interval from the real-time change trend diagram of the QTc interval and feeding back the maximum value of the QTc interval to the test terminal, it is not necessary for primary care physicians to manually calculate the QTc interval, the test accuracy is higher, and the efficiency of obtaining test data is greatly improved. In addition, the experience requirements for medical staff are greatly reduced, which is conducive to primary care physicians or non-arrhythmia physicians to quickly obtain QTc interval data.

[0150] Each module in the device for measuring the QTc interval during the treadmill exercise test can be implemented in whole or in part by software, hardware, or a combination thereof. Each module can be embedded in or independent of a processor in a computer device in the form of hardware, or can be stored in a memory in a computer device in the form of software, so that the processor can call and execute operations corresponding to each module.

[0151] In an exemplary embodiment, a computer device is provided. The computer device may be a terminal, and its internal structure diagram may be as shown in FIG. Figure 6As shown. The computer device includes a processor, a memory, an input / output interface, a communication interface, a display unit and an input device. Wherein, the processor, the memory and the input / output interface are connected through a system bus, and the communication interface, the display unit and the input device are connected to the system bus through the input / output interface. Wherein, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The input / output interface of the computer device is used to exchange information between the processor and the external device. The communication interface of the computer device is used to communicate with an external terminal in a wired or wireless manner, and the wireless manner can be implemented through WIFI, a mobile cellular network, near field communication (Near Field Communication, NFC) or other technologies. When the computer program is executed by the processor, a method for measuring the QTc interval during a flat exercise test is implemented. The display unit of the computer device is used to form a visually visible picture, which can be a display screen, a projection device or a virtual reality imaging device. The display screen can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device can be a touch layer covering the display screen, or a button, trackball or touchpad set on the computer device shell, or an external keyboard, touchpad or mouse.

[0152] Those skilled in the art will understand that Figure 6 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0153] In an exemplary embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and when the processor executes the computer program, the following steps are implemented:

[0154] During the treadmill exercise test, electrocardiogram data is collected according to a preset method; the starting point of the QRS complex and the end point of the T wave are respectively determined from the electrocardiogram data; the measured QT interval is determined according to the starting point of the QRS complex and the end point of the T wave; the measured QT interval is first corrected by the time limit of the QRS complex to obtain a corrected QT interval; according to the change in the heart rate of the subject during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain a QTc interval; according to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval is drawn.

[0155] In one embodiment, a computer readable storage medium is provided, on which a computer program is stored, and when the computer program is executed by a processor, the following steps are implemented:

[0156] During the treadmill exercise test, electrocardiogram data is collected according to a preset method; the starting point of the QRS complex and the end point of the T wave are respectively determined from the electrocardiogram data; the measured QT interval is determined according to the starting point of the QRS complex and the end point of the T wave; the measured QT interval is first corrected by the time limit of the QRS complex to obtain a corrected QT interval; according to the change in the heart rate of the subject during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain a QTc interval; according to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval is drawn.

[0157] In one embodiment, a computer program product is provided, comprising a computer program, which, when executed by a processor, implements the following steps:

[0158] During the treadmill exercise test, electrocardiogram data is collected according to a preset method; the starting point of the QRS complex and the end point of the T wave are respectively determined from the electrocardiogram data; the measured QT interval is determined according to the starting point of the QRS complex and the end point of the T wave; the measured QT interval is first corrected by the time limit of the QRS complex to obtain a corrected QT interval; according to the change in the heart rate of the subject during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain a QTc interval; according to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval is drawn.

[0159] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, stored data, displayed data, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of relevant data must comply with relevant regulations.

[0160] Those of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to the memory, database or other medium used in the embodiments provided in the present application can include at least one of non-volatile memory and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM). The database involved in each embodiment provided in this application may include at least one of a relational database and a non-relational database. Non-relational databases may include distributed databases based on blockchains, etc., but are not limited to this. The processor involved in each embodiment provided in this application may be a general-purpose processor, a central processing unit, a graphics processor, a digital signal processor, a programmable logic device, a data processing logic device based on quantum computing, an artificial intelligence (AI) processor, etc., but are not limited to this.

[0161] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this application.

[0162] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the present application shall be subject to the attached claims.

Claims

1. A method for measuring the QTc interval during a treadmill exercise test, characterized in that: The method comprises: During the treadmill exercise test, electrocardiogram data were collected according to the preset method; From the electrocardiogram data, respectively determine the QRS complex start point and the T wave end point; Determine the measured QT interval according to the QRS complex start point and the T wave end point; Performing a first correction on the measured QT interval by the duration of the QRS complex to obtain a corrected QT interval; According to the change of the subject's heart rate during the treadmill exercise test, the corrected QT interval is automatically corrected for a second time to obtain the QTc interval; According to the different stages of the treadmill exercise test, a real-time change trend graph of the QTc interval was drawn.

2. The method according to claim 1, characterized in that During the treadmill exercise test, the electrocardiogram data is collected according to a preset method, including any of the following methods: If manual measurement is adopted, at least three sinus rhythms are measured continuously, and the average value of the measured sinus rhythms is calculated to obtain the electrocardiogram data; If the measurement is performed automatically, a target electrocardiogram device is selected to collect electrocardiogram data; the target electrocardiogram device includes any one of 12 leads, II leads, V2 leads, V5 leads, and V6 leads.

3. The method according to claim 1, characterized in that: Determining the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data respectively includes: Determining whether a double T wave peak appears in the electrocardiogram data; If no T wave double peaks appear in the electrocardiogram data, the end point of the T wave is determined at the end position of the descending section of the first peak of the T wave; If a double peak of T wave appears in the electrocardiogram data, determining whether the double peak of T wave overlaps with the U wave; If the double peak of the T wave does not overlap with the U wave, the end point of the T wave is determined at the end of the descending segment of the second peak of the T wave; If the double peak of the T wave overlaps with the U wave, and the amplitude of the U wave is lower than the isoelectric line, the end point of the T wave is determined at the end of the descending segment of the second peak of the T wave; If the double peak of the T wave overlaps with the U wave, and the amplitude of the U wave is not lower than the isoelectric line, then start from the second peak of the T wave to find a tangent with the largest slope along the direction of the end of the T wave, and take the intersection of the tangent and the baseline as the end point of the T wave.

4. The method according to claim 3, characterized in that The determining whether a double T wave peak appears in the electrocardiogram data comprises: Obtaining the interval between two wave peaks that appear after the QRS wave group; if the interval is greater than a preset value, it is considered that no T wave double peaks appear; if the interval is not greater than a first preset value, it is considered that a T wave double peak appears; The determining whether the T wave double peak and the U wave overlap comprises: The notches of the two peaks that appear after the QRS complex are obtained. If the notches of the two peaks are both above the second preset value, it is considered that the T wave double peak does not overlap with the U wave; if the notch of one of the peaks is below the second preset value, it is considered that the T wave double peak overlaps with the U wave.

5. The method according to any one of claims 1 to 4, characterized in that: The first correction of the measured QT interval by the duration of the QRS complex to obtain the corrected QT interval includes any of the following methods: Method 1: subtracting a preset percentage of the QRS complex duration from the measured QT interval to obtain a corrected QT interval; Method 2: Measure the interval from the end point of the QRS wave to the end point of the T wave to obtain the JT interval, and add the JT interval to the corresponding correction value according to different genders to obtain the corrected QT interval.

6. The method according to any one of claims 1 to 4, characterized in that: The method of automatically performing a second correction on the corrected QT interval according to the change in the heart rate of the subject during the treadmill exercise test to obtain the QTc interval comprises: If the heart rate of the subject during the treadmill exercise test is not greater than the third preset value, the corrected QT interval is corrected for the second time according to the square root of the RR interval to obtain the QTc interval; If the heart rate of the subject during the treadmill exercise test is greater than the third preset value, the corrected QT interval is corrected for the second time according to the cube root of the RR interval to obtain the QTc interval.

7. The method according to any one of claims 1 to 4, characterized in that: After drawing a real-time change trend graph of the QTc interval according to different stages of the treadmill exercise test, the method further includes: Extracting the maximum value of the QTc interval from the real-time change trend graph of the QTc interval; The maximum value of the QTc interval is fed back to the test terminal.

8. A device for measuring the QTc interval during a treadmill exercise test, characterized in that: The device comprises: The acquisition module is used to collect electrocardiogram data according to a preset method during the treadmill exercise test; A determination module, used to determine the starting point of the QRS complex and the end point of the T wave from the electrocardiogram data; A QT interval measurement module, used to determine the measured QT interval according to the starting point of the QRS complex and the end point of the T wave; A first correction module, used for performing a first correction on the measured QT interval by the time limit of the QRS complex to obtain a corrected QT interval; A second correction module is used to automatically perform a second correction on the corrected QT interval according to the heart rate change of the subject during the treadmill exercise test to obtain a QTc interval; The trend graph drawing module is used to draw a real-time change trend graph of the QTc interval according to different stages of the treadmill exercise test.

9. A computer device comprising a memory and a processor, wherein the memory stores a computer program, wherein: When the processor executes the computer program, the steps of the method according to any one of claims 1 to 7 are implemented.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 7 are implemented.

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