Oral liquid for alleviating premature ovarian failure and preventing cervical cancer and preparation method thereof

Abstract

The oral liquid is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-7 parts of colla corii asini, 5-9 parts of radix polygonati officinalis, 3-7 parts of endothelium corneum gigeriae galli, 12-20 parts of cuttlefish, 7-13 parts of rhizoma polygonati, 6-11 parts of ginseng, 5-11 parts of poria cocos, 1-4 parts of angelica sinensis, 3-10 parts of radix ophiopogonis, 2-7 parts of chrysanthemum, 1-4 parts of radix puerariae, 2-5 parts of loofah sponge, 2-5 parts of clove, 3-6 parts of rice wine and 0-2 parts of white granulated sugar. Various traditional Chinese medicines contain various beneficial components, follow the medication principle of a traditional Chinese medicine prescription, are reasonable in formula, safe in medication, good in curative effect and convenient to use, and have obvious effects of regulating qi and blood of women, relieving premature ovarian failure, improving sleep, delaying climacteric and preventing cervical cancer.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to an oral liquid for slowing down premature ovarian failure and preventing cervical cancer and a preparation method thereof. Background Art

[0002] Premature ovarian failure refers to the failure of ovarian function in women before the age of 40, a type of gynecological disease characterized by increased serum follicle-stimulating hormone and luteinizing hormone concentrations and decreased estradiol concentrations, manifested as prolonged menstrual cycles or even amenorrhea, decreased reproductive function leading to infertility. In recent years, the incidence of POF has gradually increased and has a trend of younger development, with the incidence rate of women under 40 years old being 1-3% and the incidence rate of women under 30 years old being 0.1%.

[0003] Menopause is a period of transition from the beginning of the decline of female gonadal function to complete loss of function. Menopause usually occurs between the ages of 45 and 55.

[0004] At present, POF is believed to be the result of the combined effects of multiple factors and pathways, including oxidative stress, autoimmune diseases, changes in telomere length and telomerase activity, and neuro-endocrine system disorders. The main causes of menopausal syndrome are ovarian aging and estrogen reduction. Menopause is a transitional period in which ovarian function gradually declines from a vigorous state to complete disappearance. In response to premature ovarian failure, aging, and estrogen reduction, Western medicine often uses hormone replacement therapy. Although the effect is good, long-term high-dose use of estrogen can cause serious complications such as uterine bleeding, endometrial cancer, and breast cancer.

[0005] Therefore, in view of the technical problems described above, there is an urgent need for a drug that can slow down premature ovarian failure and prevent cervical cancer. Summary of the invention

[0006] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide an oral liquid which is easy to use and has few complications and can slow down premature ovarian failure and prevent cervical cancer.

[0007] According to the theory of traditional Chinese medicine, Chinese medicine believes that premature ovarian failure is mainly caused by kidney essence deficiency, spleen deficiency and blood deficiency, and the treatment is to tonify the kidney and replenish essence, strengthen the spleen and nourish the blood. The present invention is made of the following Chinese medicinal raw materials in parts by weight: 4-7 parts of donkey-hide gelatin, 5-9 parts of polygonatum, 3-7 parts of chicken's gizzard lining, 12-20 parts of cuttlefish, 7-13 parts of polygonatum, 6-11 parts of ginseng, 5-11 parts of tuckahoe, 1-4 parts of angelica, 3-10 parts of ophiopogon, 2-7 parts of chrysanthemum, 1-4 parts of kudzu root, 2-5 parts of loofah, 2-5 parts of cloves, 3-6 parts of rice wine and 0-2 parts of white granulated sugar.

[0008] Preferably, the present invention is made of the following Chinese medicinal raw materials in parts by weight: 4 parts of donkey-hide gelatin, 5 parts of polygonatum, 3 parts of chicken's gizzard lining, 12 parts of cuttlefish, 7 parts of polygonatum, 6 parts of ginseng, 5 parts of poria, 1 part of angelica, 3 parts of ophiopogon, 2 parts of chrysanthemum, 1 part of kudzu root, 2 parts of loofah, 2 parts of cloves, 3 parts of rice wine, and 1 part of white granulated sugar.

[0009] Preferably, the present invention is prepared from the following Chinese medicinal raw materials in parts by weight: 7 parts of donkey-hide gelatin, 9 parts of polygonatum odoratum, 7 parts of chicken's gizzard lining, 20 parts of cuttlefish, 13 parts of polygonatum, 11 parts of ginseng, 11 parts of poria, 4 parts of angelica, 10 parts of ophiopogon, 7 parts of chrysanthemum, 4 parts of kudzu root, 5 parts of loofah, 5 parts of cloves, 6 parts of rice wine, and 2 parts of white granulated sugar.

[0010] In the present invention, donkey-hide gelatin has a sweet taste, a neutral nature, and is in the lung, liver, and kidney meridians. It has the effects of nourishing blood, nourishing yin, moistening the lungs, and stopping bleeding; it is mainly used to treat various blood deficiency syndromes, bleeding syndromes, dry cough due to lung yin deficiency, yin damage due to fever, restlessness and insomnia, wind movement due to yin deficiency, and obstruction and convulsions;

[0011] Polygonatum odoratum: sweet in taste, neutral in nature, enters the lung and kidney meridians, and has the effects of nourishing yin and dryness, promoting body fluid and quenching thirst; it is mainly used to treat dryness and heat cough, thirst due to loss of body fluid, yin deficiency and exogenous infection, headache and fever, etc.

[0012] Chicken gizzard lining, sweet in taste, neutral in nature, enters the spleen, stomach, small intestine, and bladder meridians, has the effects of digesting food, strengthening the stomach, astringing sperm and stopping nocturnal emission; it is mainly used to treat food stagnation, infantile malnutrition, spermatorrhea due to kidney deficiency, nocturnal emission, sandstone stranguria, and gallstones;

[0013] Cuttlefish is sweet in taste and cold in nature. It enters the spleen and stomach meridians and has the effects of replenishing essence and qi, strengthening the spleen and promoting water, nourishing blood and yin, and astringing and stopping bleeding.

[0014] Polygonatum sibiricum: sweet in taste, neutral in nature, enters the spleen, lung and kidney meridians, has the effects of nourishing yin and moistening the lungs, tonifying the spleen and replenishing qi, nourishing the kidneys and replenishing essence; mainly treats yin deficiency and fatigue cough, dry lung cough, spleen deficiency and fatigue, poor appetite and dry mouth, thirst, kidney deficiency and soreness of waist and knees, impotence and spermatorrhea, tinnitus and dark eyes, premature graying of hair and beard, physical weakness and emaciation, wind leprosy and tinea;

[0015] Ginseng: sweet, slightly bitter, slightly warm in nature, enters the spleen, lung, and heart meridians, has the effects of greatly replenishing vital energy, tonifying the spleen and lungs, promoting the production of body fluids, calming the mind and improving intelligence; mainly treats qi deficiency, spleen deficiency, sinking of middle qi, shortness of breath and fatigue, thirst due to loss of body fluids, thirst due to deficiency heat, insomnia and forgetfulness, palpitations, stagnation of blood, impotence and cold uterus, etc.

[0016] Poria: sweet, light, neutral in nature, enters the heart, lung, spleen, and kidney meridians, has the effects of promoting diuresis and reducing swelling, dispelling dampness, strengthening the spleen, and calming the mind; mainly used to treat edema, phlegm and fluid retention, spleen deficiency diarrhea, palpitations, and insomnia;

[0017] Angelica: sweet and pungent in taste, warm in nature, enters the liver, heart and spleen meridians, has the effects of nourishing blood and regulating menstruation, promoting blood circulation and relieving pain, and moistening the intestines and relieving constipation; mainly treats blood deficiency and sallow complexion, irregular menstruation, amenorrhea and dysmenorrhea, blood deficiency, blood stasis, blood cold and various pains, traumatic injuries, rheumatic arthralgia, carbuncle sores, dry intestines and constipation;

[0018] Ophiopogon japonicus: sweet, slightly bitter, slightly cold in nature, enters the heart, lung, and stomach meridians, has the effects of promoting fluid production and quenching thirst, moistening the lungs and relieving cough; mainly used to treat dry cough due to lung dryness, tuberculosis due to yin deficiency, sore throat due to throat numbness, thirst due to fluid loss, internal heat and thirst, restlessness and insomnia, and constipation due to dry intestines;

[0019] Chrysanthemum: bitter and sweet, slightly cold in nature, enters the lung and liver meridians, has the effects of dispersing wind-heat, calming liver yang, clearing the liver and improving eyesight, clearing away heat and detoxifying; mainly treats wind-heat cold, initial stage of febrile disease, dizziness caused by liver yang, liver wind syndrome, red and blurred eyes, sores, carbuncle and swelling;

[0020] Pueraria root: sweet and pungent in taste, cool in nature, enters the spleen and stomach meridians, has the effects of relieving muscle and reducing fever, clearing rashes, promoting fluid and relieving thirst, and raising yang and stopping diarrhea; mainly used to treat fever due to superficial symptoms, stiff neck and back pain, measles that does not clear up, thirst due to febrile disease, thirst due to yin deficiency, hot diarrhea and dysentery, and diarrhea due to spleen deficiency;

[0021] Luffa: sweet in taste, neutral in nature, enters the lung, stomach, and liver meridians, has the effects of dispelling wind, unblocking meridians, and activating blood circulation; mainly treats rheumatic arthralgia, chest and flank pain, milk obstruction, mastitis, traumatic injury, chest pain, etc.

[0022] Clove: spicy, warm in nature, enters the spleen, stomach, and kidney meridians, has the effects of warming the middle and lowering adverse reactions, warming the kidney and supporting yang; mainly treats stomach cold hiccups, cold pain in the abdomen, poor appetite, vomiting and diarrhea, kidney deficiency and impotence, soreness and coldness of the waist and knees, and yin carbuncle;

[0023] From the above analysis, it can be seen that the effective combination of the above-mentioned drugs and their mutual support can restore the ovarian wet weight and ovarian index of ovarian damage to normal, effectively improve body disorders, and restore the normal development of follicles; at the same time, it can regulate female qi and blood, restore various female hormones to normal, improve sleep, delay the onset of menopause, and has a good effect on preventing cervical cancer.

[0024] The present invention also discloses a method for preparing an oral liquid for slowing down premature ovarian failure and preventing cervical cancer, comprising the following steps:

[0025] 1) Weighing: Weigh each raw material component according to the proportion, clean it, and grind all the raw materials except donkey-hide gelatin, sugar and rice wine into coarse powder and mix them for later use;

[0026] 2) Soaking: Soak the Chinese medicine mixture obtained in step (1) in water 6 times its weight for 2-2.5 hours;

[0027] 3) Boiling: Heat the soaked Chinese medicine mixture with water, boil it for 5-7 hours, and then simmer for another 5-7 hours;

[0028] 4) Secondary boiling: Take out the liquid medicine from the boiled Chinese medicine mixture, add 5 times the weight of water again and heat, heat to boil, then boil for 5-7 hours, and then simmer for another 5-7 hours;

[0029] 5) taking out the medicinal liquid from the mixture of traditional Chinese medicines obtained by the second boiling, mixing the two medicinal liquids, heating the weighed donkey-hide gelatin in step 1), stirring evenly, and then heating into a viscous state;

[0030] 6) After the liquid medicine obtained in step 5) is cooled to room temperature, the weighed sugar and rice wine in step 1) are added and stirred evenly.

[0031] Preferably, the concentration of the heated liquid medicine obtained in step 5) is 90-95%. When using, drink one bottle directly before going to bed every night, each bottle is about 50 ml.

[0032] The present invention follows the principles of Chinese medicine, has a reasonable formula, safe medication, good efficacy, and is easy to use. It has obvious effects on regulating female qi and blood, slowing down premature ovarian failure, improving sleep, delaying menopause, and preventing cervical cancer. The inventor of the present invention has integrated a variety of sciences and developed a method of adding white sugar and rice wine as medicine guides to make it more effectively absorbed by the human body, which is a major innovation of the present invention. DETAILED DESCRIPTION

[0033] Embodiment 1:

[0034] An oral liquid for slowing down premature ovarian failure and preventing cervical cancer is prepared from the following Chinese medicinal raw materials in parts by weight: 4 parts of donkey-hide gelatin, 5 parts of polygonatum odoratum, 3 parts of chicken's gizzard lining, 12 parts of cuttlefish, 7 parts of polygonatum sibiricum, 6 parts of ginseng, 5 parts of poria, 1 part of angelica sinensis, 3 parts of ophiopogon japonicus, 2 parts of chrysanthemum, 1 part of kudzu root, 2 parts of loofah, 2 parts of cloves, 3 parts of rice wine and 1 part of white granulated sugar.

[0035] The preparation method thereof comprises the following steps:

[0036] 1) Weighing: Weigh each raw material component according to the proportion, clean it, and grind all the raw materials except donkey-hide gelatin, sugar and rice wine into coarse powder and mix them for later use;

[0037] 2) Soaking: Soak the Chinese medicine mixture obtained in step (1) in water 6 times its weight for 2 hours;

[0038] 3) Boiling: Heat the soaked Chinese medicine mixture with water, boil it for 6 hours, and then simmer for another 6 hours;

[0039] 4) Secondary boiling: Take out the liquid from the boiled Chinese medicine mixture, add 5 times the weight of water again and heat, heat to boil, then boil for 6 hours, and then simmer for another 6 hours;

[0040] 5) taking out the medicinal liquid from the mixture of traditional Chinese medicines obtained by the second boiling, mixing the two medicinal liquids, heating the weighed donkey-hide gelatin in step 1), stirring evenly, and then heating into a viscous state;

[0041] 6) After the liquid medicine obtained in step 5) is cooled to room temperature, the weighed sugar and rice wine in step 1) are added and stirred evenly.

[0042] Preferably, the concentration of the heated liquid medicine obtained in step 5) is about 95%. When using, drink one bottle directly before going to bed every night, each bottle is 50 ml.

[0043] Embodiment 2:

[0044] An oral liquid for slowing down premature ovarian failure and preventing cervical cancer is prepared from the following Chinese medicinal raw materials in parts by weight: 7 parts of donkey-hide gelatin, 9 parts of polygonatum odoratum, 7 parts of chicken's gizzard lining, 20 parts of cuttlefish, 13 parts of polygonatum sibiricum, 11 parts of ginseng, 11 parts of poria, 4 parts of angelica sinensis, 10 parts of ophiopogon japonicus, 7 parts of chrysanthemum, 4 parts of kudzu root, 5 parts of loofah, 5 parts of cloves, 6 parts of rice wine and 2 parts of white granulated sugar.

[0045] The preparation method thereof comprises the following steps:

[0046] 1) Weighing: Weigh each raw material component according to the proportion, clean it, and grind all the raw materials except donkey-hide gelatin, sugar and rice wine into coarse powder and mix them for later use;

[0047] 2) Soaking: Soak the Chinese medicine mixture obtained in step (1) in water 6 times its weight for 2 hours;

[0048] 3) Boiling: Heat the soaked Chinese medicine mixture with water, boil it for 6 hours, and then simmer for another 6 hours;

[0049] 4) Secondary boiling: Take out the liquid from the boiled Chinese medicine mixture, add 5 times the weight of water again and heat, heat to boil, then boil for 6 hours, and then simmer for another 6 hours;

[0050] 5) taking out the medicinal liquid from the mixture of traditional Chinese medicines obtained by the second boiling, mixing the two medicinal liquids, heating the weighed donkey-hide gelatin in step 1), stirring evenly, and then heating into a viscous state;

[0051] 6) After the liquid medicine obtained in step 5) is cooled to room temperature, the weighed sugar and rice wine in step 1) are added and stirred evenly.

[0052] Preferably, the concentration of the heated liquid medicine obtained in step 5) is about 95%. When using, drink one bottle directly before going to bed every night, each bottle is 50 ml.

[0053] Embodiment three:

[0054] An oral liquid for slowing down premature ovarian failure and preventing cervical cancer is prepared from the following Chinese medicinal raw materials in parts by weight: 5 parts of donkey-hide gelatin, 7 parts of polygonatum odoratum, 5 parts of chicken's gizzard lining, 16 parts of cuttlefish, 10 parts of polygonatum sibiricum, 9 parts of ginseng, 8 parts of poria, 3 parts of angelica sinensis, 6 parts of ophiopogon japonicus, 4 parts of chrysanthemum, 3 parts of kudzu root, 3 parts of loofah, 3 parts of cloves, 4 parts of rice wine and 1 part of white granulated sugar.

[0055] The preparation method thereof comprises the following steps:

[0056] 1) Weighing: Weigh each raw material component according to the proportion, clean it, and grind all the raw materials except donkey-hide gelatin, sugar and rice wine into coarse powder and mix them for later use;

[0057] 2) Soaking: Soak the Chinese medicine mixture obtained in step (1) in water 6 times its weight for 2 hours;

[0058] 3) Boiling: Heat the soaked Chinese medicine mixture with water, boil it for 6 hours, and then simmer for another 6 hours;

[0059] 4) Secondary boiling: Take out the liquid from the boiled Chinese medicine mixture, add 5 times the weight of water again and heat, heat to boil, then boil for 6 hours, and then simmer for another 6 hours;

[0060] 5) taking out the medicinal liquid from the mixture of traditional Chinese medicines obtained by the second boiling, mixing the two medicinal liquids, heating the weighed donkey-hide gelatin in step 1), stirring evenly, and then heating into a viscous state;

[0061] 6) After the liquid medicine obtained in step 5) is cooled to room temperature, the weighed sugar and rice wine in step 1) are added and stirred evenly.

[0062] Preferably, the concentration of the heated liquid medicine obtained in step 5) is about 95%. When using, drink one bottle directly before going to bed every night, each bottle is 50 ml.

[0063] Diagnostic criteria for the disease: 1) Age of onset before 40 years old; 2) Oligomenorrhea or amenorrhea for at least 4 months; 3) Repeated measurements of serum follicle-stimulating hormone at menopausal levels; accompanied by symptoms such as anemia, anemia, and infertility.

[0064] Control experiment:

[0065] 96 purebred female SD rats, SPF grade, weighing 200-250 g, 7-8 weeks old were selected;

[0066] Experimental group 1: 24 mice were selected and the oral solution prepared in Example 1 of the present invention was taken orally once every night, 0.2-0.3 ml each time, for 30 days per course, for a total of 3 courses;

[0067] Experimental group 2: 24 mice were selected and the oral solution prepared in Example 2 of the present invention was taken orally once every night, 0.2-0.3 ml each time, for 30 days per course, for a total of 3 courses;

[0068] Experimental group 3: 24 mice were selected and the oral solution prepared in Example 3 of the present invention was taken orally once every night, 0.2-0.3 ml each time, for 30 days per course, for a total of 3 courses;

[0069] Control group: no drug treatment was used.

[0070] Comparison table:

[0071] Group efficient invalid Experimental Group 1 21 3 Experimental Group 2 20 4 Experimental Group 3 23 1 Control group 0 24

[0072] It can be seen from the comparison table that the formula of the present invention has significant effects in treating premature ovarian failure, regulating female qi and blood, improving sleep, and delaying menopause.

[0073] Typical cases:

[0074] 1 Yang Moumou, female, 38 years old, had oligomenorrhea 3 years ago. The serum follicle stimulating hormone was at the menopausal level. At the same time, she had insufficient Qi and blood. After diagnosis, she was determined to have premature ovarian failure. After using the oral liquid of the Chinese medicine composition of the present invention, after 3 courses of treatment, her menstruation returned to normal, her Qi and blood were sufficient, her sleep was sufficient, and her physical condition improved.

[0075] 2 Li, female, 36 years old, had oligomenorrhea 1 year ago. The serum follicle stimulating hormone was at the menopausal level. At the same time, she had insufficient qi and blood. She was diagnosed with premature ovarian failure. After using the oral liquid of the Chinese medicine composition of the present invention, her menstruation returned to normal after 3 courses of treatment, her sleep was adequate, and her physical condition improved.

[0076] 3 Wang, female, 37 years old, had oligomenorrhea 2 years ago. The serum follicle stimulating hormone was at the menopausal level. At the same time, she had insufficient qi and blood. She was diagnosed with premature ovarian failure. After using the oral liquid of the Chinese medicine composition of the present invention, her menstruation returned to normal after 3 courses of treatment and her sleep quality was good.

[0077] The present invention and its implementation methods are described above, and such description is not restrictive, and the above implementation methods are not intended to limit the patent scope of the present invention. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. An oral liquid for slowing down premature ovarian failure and preventing cervical cancer, characterized in that: The oral liquid is prepared from the following Chinese medicinal raw materials in parts by weight: 4-7 parts of donkey-hide gelatin, 5-9 parts of polygonatum odoratum, 3-7 parts of chicken's gizzard lining, 12-20 parts of cuttlefish, 7-13 parts of polygonatum sibiricum, 6-11 parts of ginseng, 5-11 parts of tuckahoe, 1-4 parts of angelica sinensis, 3-10 parts of ophiopogon japonicus, 2-7 parts of chrysanthemum, 1-4 parts of kudzu root, 2-5 parts of loofah, 2-5 parts of cloves, 3-6 parts of rice wine, and 0-2 parts of white granulated sugar.

2. The oral liquid for slowing down premature ovarian failure and preventing cervical cancer according to claim 1, characterized in that: The oral liquid is prepared from the following Chinese medicinal raw materials in parts by weight: 4 parts of donkey-hide gelatin, 5 parts of polygonatum odoratum, 3 parts of chicken's gizzard lining, 12 parts of cuttlefish, 7 parts of polygonatum sibiricum, 6 parts of ginseng, 5 parts of poria, 1 part of angelica sinensis, 3 parts of ophiopogon japonicus, 2 parts of chrysanthemum, 1 part of kudzu root, 2 parts of loofah, 2 parts of cloves, 3 parts of rice wine, and 1 part of white granulated sugar.

3. The oral liquid for slowing down premature ovarian failure and preventing cervical cancer according to claim 1, characterized in that: The oral liquid is prepared from the following Chinese medicinal raw materials in parts by weight: 7 parts of donkey-hide gelatin, 9 parts of polygonatum odoratum, 7 parts of chicken's gizzard lining, 20 parts of cuttlefish, 13 parts of polygonatum sibiricum, 11 parts of ginseng, 11 parts of poria, 4 parts of angelica sinensis, 10 parts of ophiopogon japonicus, 7 parts of chrysanthemum, 4 parts of kudzu root, 5 parts of loofah, 5 parts of cloves, 6 parts of rice wine, and 2 parts of white granulated sugar.

4. The oral liquid for preventing premature ovarian failure and cervical cancer according to claim 1, characterized in that: The alcohol content of the rice wine is 1.5-3%.

5. The method for preparing an oral liquid for slowing down premature ovarian failure and preventing cervical cancer according to any one of claims 1 to 4, characterized in that: The following steps are involved: 1) Weighing: Weigh each raw material component in proportion, clean it, and grind all the raw materials except donkey-hide gelatin, sugar, and rice wine into coarse powder and mix them for later use; 2) Soaking: Soak the Chinese medicine mixture obtained in step (1) in water 6 times its weight for 2-2.5 hours; 3) Boiling: Heat the soaked Chinese medicine mixture with water, boil it for 5-7 hours, and then simmer for another 5-7 hours; 4) Secondary boiling: Take out the liquid medicine from the boiled Chinese medicine mixture, add 5 times the weight of water again and heat, heat to boil, then boil for 5-7 hours, and then simmer for another 5-7 hours; 5) taking out the medicinal liquid from the mixture of traditional Chinese medicines obtained by the second boiling, mixing the two medicinal liquids, heating the weighed donkey-hide gelatin in step 1), stirring evenly, and then heating into a viscous state; 6) After the liquid medicine obtained in step 5) is cooled to room temperature, the weighed sugar and rice wine in step 1) are added and stirred evenly.

6. The method for preparing an oral liquid for slowing down premature ovarian failure and preventing cervical cancer according to claim 5, characterized in that: The concentration of the heated drug solution obtained in step 5) is 90-95%.