Fat-soluble traditional Chinese medicine lip balm for regulating menstrual cycle and preparation method of fat-soluble traditional Chinese medicine lip balm

Abstract

The invention discloses a fat-soluble traditional Chinese medicine lip balm for regulating the menstrual cycle and a preparation method thereof. The fat-soluble traditional Chinese medicine lip balm comprises a traditional Chinese medicine extract, and the traditional Chinese medicine extract is prepared from, by weight, 240-280 parts of radix angelicae sinensis, 60-80 parts of radix adenophorae, 160-200 parts of fructus alpiniae oxyphyllae, 60-80 parts of rhizoma atractylodis macrocephalae and 60-80 parts of rhizoma chuanxiong. The traditional Chinese medicine composition can enrich and activate blood, nourish yin and clear away lung-heat, tonify stomach and promote salivation, reduce phlegm and tonify qi, can safely and continuously prolong the menstrual cycle, is free of toxic and side effects, has a certain relieving effect on dysmenorrhea, is absorbed through lip mucosa to avoid damage of gastrointestinal tracts, livers and the like to effective components of traditional Chinese medicines, is convenient to use, and can achieve a good menstrual cycle improving effect even if the dosage of the traditional Chinese medicines is small.

Description

Technical Field

[0001] The invention relates to a preparation method of a fat-soluble Chinese medicine lip balm for regulating menstrual cycle, and belongs to the technical field of Chinese medicines. Background Art

[0002] The menstrual cycle is an important part of the female physiological cycle. Statistics show that women with relatively short menstrual cycles (21-27 days) have significantly lower ovarian reserve function, fertility and pregnancy after embryo transfer than women with menstrual cycles (28-35 days). Short menstrual cycles will lead to more menstruation each year, relatively more blood loss, and easily lead to dizziness, anemia, etc. At the same time, women ovulate once every menstruation, and ovulate about 400 times in their lifetime. If the menstrual cycle is short, the number of ovulations will increase each year, and the egg cells will be discharged in a relatively short time, entering menopause early. Calculated from the beginning of menstruation at the age of 12, with a cycle of 25 days, menopause will occur around the age of 40, and menopause will occur around the age of 50 with a menstrual cycle of 35 days. 2-4% of women worldwide will menopause before the age of 40, 12% of women will menopause at the age of 40-44, and 80% will menopause at the age of 44-54. After menopause, ovarian function declines, and the secretion of estrogen and progesterone decreases, leading to skin aging, increased wrinkles, etc. The body's metabolic system, urinary system, cardiovascular system, etc. will gradually become abnormal and aged. Therefore, effectively extending the menstrual cycle and reducing the rate of egg cell release can postpone menopause and effectively slow down the aging process of women.

[0003] Currently, there are two main methods on the market for extending the menstrual cycle. The first is to take oral progestin drugs, such as progesterone, dydrogesterone, etc., in the second half of the menstrual cycle. The second is oral short-acting contraceptives. Oral hormone western medicine only treats the symptoms and not the root cause. It has great side effects and may disrupt the body's endocrine system and cause menstrual disorders. Long-term use may also lead to obesity, osteoporosis, etc. Summary of the invention

[0004] In view of the above problems, the first purpose of the present invention is to provide a fat-soluble Chinese medicine lip balm for regulating the menstrual cycle, and the second purpose is to provide a preparation method of the fat-soluble Chinese medicine lip balm for regulating the menstrual cycle. It can safely and continuously extend the menstrual cycle, has no toxic side effects, and also has a certain effect on relieving dysmenorrhea.

[0005] In order to achieve the above-mentioned first purpose, the technical solution of the present invention is: a fat-soluble Chinese medicine lip balm for regulating menstrual cycle, characterized in that it contains Chinese medicine extracts, which are made of 240-280 parts by weight of Angelica sinensis, 60-80 parts of Adenophora australis, 160-200 parts of Alpinia oxyphylla, 60-80 parts of Atractylodes macrocephala, and 60-80 parts of Ligusticum chuanxiong.

[0006] In the above scheme: it also contains an oily liquid, which is made of 22-30 parts by weight of olive oil, 11-15 parts of jojoba oil, 11-15 parts of lanolin, 7-9 parts of beeswax, 11-13 parts of sweet almond oil, 4-7 parts of castor oil, 9-11 parts of palm wax, 18-20 parts of glycerol, and 9-12 parts of glyceryl monostearate.

[0007] The second object of the present invention is achieved by: a method for preparing a fat-soluble Chinese medicine lip balm for regulating the menstrual cycle, characterized in that the method is prepared according to the following steps:

[0008] (1) All the Chinese medicines are ground into powder, soaked in ethyl acetate solvent overnight, then subjected to ultrasonic extraction, filtered with cotton, the filter residue is ultrasonically extracted again with ethyl acetate, filtered with cotton, the filtrate is combined, the filtrate is filtered again with filter paper, allowed to stand, filtered with filter paper until the filtrate is clear, the filtrate is evaporated to dryness, ethanol is added and ultrasonicated, and then evaporated to dryness to obtain a Chinese medicine extract;

[0009] (2) olive oil, jojoba oil, lanolin, beeswax, sweet almond oil, castor oil, palm wax, glycerin, and glyceryl monostearate are mixed in a container, stirred, and heated to obtain an oily liquid;

[0010] (3) dissolving the Chinese herbal extract in anhydrous ethanol, adding the mixture dropwise to the above oily liquid, mixing well, and cooling to room temperature;

[0011] (4) After observing that the lipstick paste is uniform, heat it to 75°C-80°C to volatilize some of the alcohol, adjust the hardness of the lipstick, and cool it to room temperature again;

[0012] (5) Finally, the paste is melted, poured into a mold, and demoulded to obtain a finished product.

[0013] In the above scheme: in terms of weight parts, in step (1), during the soaking extraction, the amount of ethyl acetate added is 1500-1700 parts, and the amount of ethyl acetate added to the filter residue is 500-700 parts.

[0014] In the above scheme: in step (1), the time of the first ultrasonic extraction is 1-1.5 hours, the time of ultrasonic extraction of the filter residue is 30-40 minutes, and the ultrasonic extraction is carried out for 10-20 minutes after adding ethanol.

[0015] In the above scheme: in step (1), ethanol is added in an amount of 30-50 parts by weight each time, and the ethanol is added 1-2 times.

[0016] In the present invention:

[0017] Angelica sinensis has the effects of nourishing blood, activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is sweet, pungent and warm in nature. It enters the liver, heart and spleen meridians. Its chemical components mainly include volatile oils (including phthalide lactones), organic acids, polysaccharides, amino acids and flavonoids. It is mainly used to treat irregular menstruation, amenorrhea and abdominal pain, mass accumulation, metrorrhagia; headache due to blood deficiency, dizziness, paralysis; dry bowel and constipation, heaviness after dysentery; carbuncle, sore, and injury from falls.

[0018] Adenophora australis has the effects of nourishing yin and clearing lungs, benefiting stomach and promoting fluid, resolving phlegm, and invigorating qi. It is sweet and slightly cold in nature. It enters the lung meridian and stomach meridian. It mainly contains polysaccharides, β-sitosterol and its derivatives, triterpenes, phospholipids and other ingredients, and has multiple pharmacological effects such as immunomodulation, anti-radiation, anti-aging, scavenging free radicals, and liver protection. It is mainly used to treat lung heat and dry cough, chronic cough due to consumptive tuberculosis, and dry throat and sore throat due to yin damage.

[0019] Alpinia oxyphylla has the effects of warming the spleen and stopping diarrhea, warming the kidney, consolidating essence and reducing urine. It is pungent and warm in nature. It enters the spleen meridian and kidney meridian. It mainly contains diarylheptanes, sesquiterpenes, flavonoids, steroids and organic acids. It has antioxidant and neuroprotective, cardiotonic and analgesic effects. It is mainly used to treat cold abdominal pain, vomiting and diarrhea caused by cold, excessive salivation, spermatorrhea, residual urine and frequent urination at night.

[0020] Atractylodes macrocephala has the effects of invigorating qi and strengthening the spleen, drying dampness and promoting diuresis. It is bitter, sweet and warm in nature. It enters the spleen and stomach meridians. It is sweet and nourishing, bitter, warm and dry. It mainly warms and strengthens the body, and can also remove dampness. It mainly contains semiterpenes such as atractylodesone and β-eudesyl alcohol, atractylodes lactones I to IV and di-atractylodes lactone. It is mainly used to treat weak spleen and stomach qi, loss of appetite, fatigue and shortness of breath, bloating, diarrhea, phlegm and fluid, edema, jaundice, dampness and arthralgia, urinary incontinence, dizziness, spontaneous sweating, and fetal restlessness.

[0021] Chuanxiong Qixiangshengsan has the effects of promoting blood circulation and qi, dispelling wind and relieving pain, and has a pungent and warm nature. It enters the liver, gallbladder, and heart meridians. Its chemical components mainly include chuanxiongzine, sodium ferulate, chuanxiong lactone, etc. It is mainly used to treat irregular menstruation, dysmenorrhea, amenorrhea, dystocia, retained placenta, postpartum lochia and abdominal pain, lumps, heart and chest pain, swelling and pain caused by falls, headache, dizziness, blurred vision, wind-cold-dampness arthralgia, limb numbness, carbuncle and ulcer.

[0022] Since oral Chinese medicine has a stimulating taste and poor patient compliance, the present invention extracts effective ingredients of Chinese medicine to prepare Chinese medicine lip balm. The lips are rich in blood vessels and are absorbed through the lip mucosa, avoiding the gastrointestinal tract, liver, etc. from damaging the effective ingredients of Chinese medicine. It is portable and can achieve a good menstrual cycle improvement effect with a smaller dose of Chinese medicine. DETAILED DESCRIPTION

[0023] The present invention will be further described below by way of examples:

[0024] Example 1

[0025] The fat-soluble Chinese medicine lip balm for regulating menstrual cycle is characterized by comprising Chinese medicine extract and oily liquid. The Chinese medicine extract is prepared by weight of 240 parts of angelica sinensis, 80 parts of Adenophora australis, 160 parts of Alpinia oxyphylla, 80 parts of Atractylodes macrocephala, and 80 parts of Ligusticum chuanxiong.

[0026] The oily liquid is prepared from 22 parts of olive oil, 11 parts of jojoba oil, 11 parts of lanolin, 7 parts of beeswax, 11 parts of sweet almond oil, 4 parts of castor oil, 9 parts of palm wax, 18 parts of glycerol and 9 parts of glyceryl monostearate in parts by weight.

[0027] Prepare according to the following steps:

[0028] (1) All the Chinese medicines were ground into powder, soaked in 1500 parts of ethyl acetate solvent overnight, and then ultrasonically extracted for 1 hour. The residue was filtered with cotton, and the residue was ultrasonically extracted again with 500 parts of ethyl acetate for 30 minutes. The residue was filtered with cotton, and the filtrate was combined. The filtrate was filtered again with filter paper, left to stand overnight, and filtered with filter paper until the filtrate was clear. The filtrate was evaporated to dryness, 50 parts of ethanol was added and ultrasonicated for 10 minutes, and then evaporated to dryness. The ethanol treatment was repeated twice to obtain the Chinese medicine extract.

[0029] (2) Mix olive oil, jojoba oil, lanolin, beeswax, sweet almond oil, castor oil, palm wax, glycerin and glyceryl monostearate in a container, stir, and heat to 75° C. to obtain an oily liquid.

[0030] (3) Dissolve the Chinese herbal medicine extract in 25 parts of anhydrous ethanol, add it dropwise to the above oily liquid, mix well, and cool to room temperature.

[0031] (4) After observing that the lipstick paste is uniform, heat it to 75℃-80℃ to volatilize part of the alcohol, adjust the hardness of the lipstick (too high ethanol content will make the lipstick softer), and cool it to room temperature again.

[0032] (5) Finally, the paste is melted, poured into a mold, and demoulded to obtain a finished product.

[0033] Example 2

[0034] The fat-soluble Chinese medicine lip balm for regulating menstrual cycle is characterized by comprising Chinese medicine extract and oily liquid. The Chinese medicine extract is prepared by weight of 280 parts of angelica sinensis, 60 parts of Adenophora australis, 200 parts of Alpinia oxyphylla, 60 parts of Atractylodes macrocephala, and 60 parts of Ligusticum chuanxiong.

[0035] The oily liquid is prepared from 30 parts of olive oil, 15 parts of jojoba oil, 15 parts of lanolin, 9 parts of beeswax, 13 parts of sweet almond oil, 7 parts of castor oil, 11 parts of palm wax, 20 parts of glycerol and 12 parts of glyceryl monostearate in parts by weight.

[0036] Prepare according to the following steps:

[0037] (1) All the Chinese medicines were ground into powder, soaked in 1700 parts of ethyl acetate solvent overnight, and then ultrasonically extracted for 1.5 hours. The residue was filtered with cotton, and the residue was ultrasonically extracted again with 700 parts of ethyl acetate for 40 minutes. The residue was filtered with cotton, and the filtrate was combined. The filtrate was filtered again with filter paper, left to stand overnight, and filtered with filter paper until the filtrate was clear. The filtrate was evaporated to dryness, 30 parts of ethanol was added and ultrasonicated for 20 minutes, and then evaporated to dryness. The ethanol treatment was repeated twice to obtain the Chinese medicine extract.

[0038] (2) Mix olive oil, jojoba oil, lanolin, beeswax, sweet almond oil, castor oil, palm wax, glycerin and glyceryl monostearate in a container, stir, and heat to 75° C. to obtain an oily liquid.

[0039] (3) Dissolve the Chinese herbal medicine extract in 30 parts of anhydrous ethanol, add it dropwise to the above oily liquid, mix well, and cool to room temperature.

[0040] (4) After observing that the lipstick paste is uniform, heat it to 75℃-80℃ to volatilize part of the alcohol, adjust the hardness of the lipstick (too high ethanol content will make the lipstick softer), and cool it to room temperature again.

[0041] (5) Finally, the paste is melted, poured into a mold, and demoulded to obtain a finished product.

[0042] Efficacy results:

[0043] 200 subjects with relatively stable menstrual cycles in the past three months were selected, with or without dysmenorrhea. The 200 subjects were divided into two groups, one with 50 subjects and the other with 150 subjects.

[0044] In the first group of 50 people, 8 people had a menstrual cycle of 21-27 days, and the remaining menstrual cycle was 28-35 days. After the menstruation, they started to use the lipstick prepared in any of Example 1 or 2 on the second day, and used the lip balm 3-4 times a day for 10-19 days in a row, which was less than one menstrual cycle. After stopping use, the users' menstrual cycle was extended by 0-3 days, of which 0-2 days of extension was considered normal and was not counted as a cycle extension. Among the 50 people, 92% had normal cycles and 8% had an extension of 3 days.

[0045] The second group of 150 people, 35 of whom had menstrual cycles of 21-27 days, and the rest of whom had menstrual cycles of 28-35 days. The people in this group started to use the lipstick prepared by any of Example 1 or 2 on the second day after their menstruation, and used the lipstick 3-4 times a day.

[0046] For 58% of the people, after using it for the first month, their menstrual cycle was extended by 3-8 days based on the initial menstrual cycle (the menstrual cycle before using the lipstick). After 3-8 days, their menstruation came normally. After the menstruation, they continued to use it until the menstruation came again. After using it for 4 consecutive months, the extension of the menstrual cycle was stable, extending by 3-8 days compared to the initial cycle.

[0047] 42% of people had their menstruation extended by 3-10 days in the first month, and continued to use lip balm after the menstruation. In the second month, the menstrual cycle was extended by about 10-20 days, and continued to use lip balm after the menstruation. In the third month, the menstrual cycle exceeded the initial menstrual cycle by 20-25 days, and if the menstruation did not come, they stopped using lip balm. The menstruation came within 5 days after stopping use, and the cycle was extended by 20-30 days. The menstrual cycle showed a trend of increasing month by month.

[0048] If lipstick is used in the short term, it will only have a short-term effect on prolonging the menstrual cycle. For example, if it is used for about one month, the menstrual cycle will be prolonged. After stopping use, the next menstrual cycle will return to the normal level before use.

[0049] The Chinese medicinal materials used in the lipstick are mild and will not cause side effects with long-term use.

[0050] Typical clinical applications

[0051] 1. Fu, 20 years old, female, menstrual status: dysmenorrhea, vomiting, diarrhea, chills on the 1st and 2nd day of menstruation, dysmenorrhea requires painkillers. Menstrual cycle is relatively regular, 29-32 days. She has been using lip balm for nearly 4 months, but stopped using it during menstruation. The menstrual period is prolonged and the chills, diarrhea and other dysmenorrhea symptoms are alleviated.

[0052] The changes in the menstrual cycle are as follows: in the first menstrual record, the device was used for 35 days, and the menstruation came 5 days after discontinuation of use. The cycle was extended by 13 days, and the total menstrual cycle was 45 days (including 5 days of menstruation). In the third menstrual record, the device was used for 53 days, and the menstruation came 4 days after discontinuation of use. The cycle was extended by 30 days, and the total menstrual cycle was 62 days (including 5 days of menstruation).

[0053] 2. Xiong, 21 years old, female, menstrual status: menstrual cycle is 30 days, and she needs to take ibuprofen for pain relief during menstruation. She has used lip balm continuously for nearly 4 months and stopped using it during menstruation. The average extension time of the cycle is relatively stable. There is no obvious change in dysmenorrhea during the first menstrual period, and she needs to take painkillers. From the second menstrual period, the dysmenorrhea is relieved and no painkillers are needed.

[0054] The menstrual cycle changes are as follows: the first menstrual record, the cycle is extended by 4 days, the third menstrual record, the cycle is extended by 4 days, the fourth menstrual record, the cycle is extended by 6 days (the number of days for extending the cycle of the present invention is relative to the initial cycle).

[0055] 3. Li, 38 years old, female, usually afraid of cold and weak, with a menstrual cycle of 24-26 days. She used the product for 4 consecutive months. Compared with before use, each menstrual cycle was extended by 3-6 days.

[0056] 4. Huang, 22 years old, female, menstrual condition: mild dysmenorrhea, regular menstrual cycle, about 30 days. First month: used lip balm for 29 days, menstruation was extended by 4 days, dysmenorrhea was relieved; second month: stopped using lip balm, menstrual cycle returned to normal.

[0057] The present invention is not limited to the above-mentioned embodiments. Those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and purpose of the present invention. The scope of the present invention is defined by the claims and their equivalents.

Claims

1. A fat-soluble Chinese medicine lip balm for regulating menstrual cycle, characterized in that: The Chinese medicine extract is prepared from 240-280 parts by weight of angelica sinensis, 60-80 parts by weight of adenophora australis, 160-200 parts by weight of alpinia oxyphylla, 60-80 parts by weight of atractylodes macrocephala and 60-80 parts by weight of ligusticum chuanxiong.

2. The fat-soluble Chinese medicine lip balm for regulating menstrual cycle according to claim 1, characterized in that: The invention also comprises an oily liquid, which is prepared from 22-30 parts by weight of olive oil, 11-15 parts of jojoba oil, 11-15 parts of lanolin, 7-9 parts of beeswax, 11-13 parts of sweet almond oil, 4-7 parts of castor oil, 9-11 parts of palm wax, 18-20 parts of glycerol and 9-12 parts of glyceryl monostearate.

3. A method for preparing the fat-soluble Chinese medicine lip balm for regulating menstrual cycle according to any one of claims 1 to 2, characterized in that: Prepare according to the following steps: (1) All the Chinese medicines are ground into powder, soaked in ethyl acetate solvent overnight, then subjected to ultrasonic extraction, filtered with cotton, the filter residue is ultrasonically extracted again with ethyl acetate, filtered with cotton, the filtrate is combined, the filtrate is filtered again with filter paper, allowed to stand, filtered with filter paper until the filtrate is clear, the filtrate is evaporated to dryness, ethanol is added and ultrasonicated, and then evaporated to dryness to obtain a Chinese medicine extract; (2) olive oil, jojoba oil, lanolin, beeswax, sweet almond oil, castor oil, palm wax, glycerin, and glyceryl monostearate are mixed in a container, stirred, and heated to obtain an oily liquid; (3) dissolving the Chinese herbal extract in anhydrous ethanol, adding the mixture dropwise to the above oily liquid, mixing well, and cooling to room temperature; (4) After the lipstick paste is observed to be uniform, heat it to 75°C-80°C to volatilize some of the alcohol, adjust the hardness of the lipstick, and cool it to room temperature again; (5) Finally, the paste is melted, poured into a mold, and demoulded to obtain a finished product.

4. The method for preparing the fat-soluble Chinese medicine lip balm for regulating menstrual cycle according to claim 3, characterized in that: In terms of weight parts, in step (1), during the soaking extraction, the amount of ethyl acetate added is 1500-1700 parts, and the amount of ethyl acetate added to the filter residue is 500-700 parts.

5. The method for preparing the fat-soluble Chinese medicine lip balm for regulating menstrual cycle according to claim 4, characterized in that: In step (1), the first ultrasonic extraction takes 1-1.5 hours, the residue ultrasonic extraction takes 30-40 minutes, and the ultrasonic extraction is performed for 10-20 minutes after the addition of ethanol.

6. The method for preparing the fat-soluble Chinese medicine lip balm for regulating menstrual cycle according to claim 5, characterized in that: In step (1), ethanol is added in an amount of 30-50 parts by weight each time, and the ethanol is added 1-2 times.