Traditional Chinese medicine composition for treating obesity as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating obesity and a preparation method and application thereof. The traditional Chinese medicine composition for treating obesity is prepared from the following components in parts by weight: 20 to 30 parts of herba artemisiae scopariae, 25 to 35 parts of fructus lycii, 10 to 20 parts of radix polygoni multiflori preparata, 15 to 25 parts of radix bupleuri, 10 to 20 parts of rhizoma atractylodis, 30 to 40 parts of exocarpium benincasae, 2 to 5 parts of folium sennae and 5 to 15 parts of fructus crataegi. According to the traditional Chinese medicine composition for treating obesity, the traditional Chinese medicinal materials without toxic or side effects are adopted as the raw materials, and under the synergistic effect of all the components, the traditional Chinese medicine composition not only has the obvious effect of lowering lipid and treating obesity, but also can be brewed with tea, has no toxic or side effects and can be taken for a long time.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating obesity, a preparation method and an application thereof. Background Art

[0002] With the improvement of people's living standards and the change of lifestyle, the number of obese people has increased significantly. Obesity is a globally prevalent independent chronic disease characterized by excessive accumulation of body fat. It not only affects people's physical beauty, but also is closely related to many chronic diseases such as diabetes, hypertension, cardiovascular and cerebrovascular diseases.

[0003] Taking diet and exercise therapy as the guide, combined with behavioral therapy, it is still not effective to control weight on this basis. Therefore, finding highly effective lipid-lowering drugs to treat obesity has become a hot social and medical issue of widespread concern today. The products for treating obesity currently circulating in the market are roughly divided into two categories: Western medicine for treating obesity and traditional Chinese medicine for treating obesity. However, Western medicine for treating obesity continues to have obvious side effects, which makes people stay away from it. Therefore, most people currently prefer traditional Chinese medicine products for treating obesity. However, the effects of traditional Chinese medicine products for treating obesity on the market are not ideal.

[0004] In view of this, the present invention is proposed. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for treating obesity, a preparation method and an application thereof; the Chinese medicine composition for treating obesity adopts non-toxic and non-side-effect Chinese medicinal materials as raw materials, not only has an obvious lipid-lowering effect for treating obesity, but also can be brewed as tea, has no toxic side effects, and can be taken for a long time.

[0006] In order to overcome the deficiencies of the prior art, the present invention provides the following technical solutions:

[0007] A Chinese medicine composition for treating obesity comprises the following components by weight: 20-30 parts of Artemisia capillaris, 25-35 parts of Lycium barbarum, 10-20 parts of processed Polygonum multiflorum, 15-25 parts of Bupleurum, 10-20 parts of Atractylodes lancea, 30-40 parts of wax gourd peel, 2-5 parts of senna leaves, and 5-15 parts of hawthorn.

[0008] Furthermore, the following components are included by weight: 22-28 parts of Artemisia capillaris, 28-32 parts of wolfberry, 12-18 parts of processed Polygonum multiflorum, 18-22 parts of Bupleurum, 12-18 parts of Atractylodes, 32-38 parts of wax gourd peel, 3-4 parts of senna leaves, and 8-12 parts of hawthorn.

[0009] Furthermore, the following components are included by weight: 25 parts of Artemisia capillaris, 30 parts of wolfberry, 15 parts of processed Polygonum multiflorum, 20 parts of Bupleurum, 15 parts of Atractylodes, 35 parts of wax gourd peel, 3.5 parts of senna leaves, and 10 parts of hawthorn.

[0010] In addition, the present invention also provides a method for preparing the above-mentioned Chinese medicine composition for treating obesity, comprising the following steps: weighing each component by weight, mixing and then crushing through an 80-100 mesh sieve to obtain a powdered Chinese medicine composition for treating obesity.

[0011] Furthermore, the method further comprises decocting the powdered Chinese medicine composition for treating obesity with water, wherein the amount of water added is 4 times the weight of the composition, and the decocting time is 15 to 20 minutes, to obtain a decoction of the Chinese medicine composition for treating obesity.

[0012] In addition, the present invention also provides the use of the above-mentioned traditional Chinese medicine composition for treating obesity in the preparation of products for treating obesity.

[0013] Furthermore, the product for treating obesity is a weight loss health tea.

[0014] Compared with the prior art, the technical solution of the present invention has at least the following technical effects:

[0015] The Chinese medicine composition for treating obesity of the present invention adopts non-toxic and non-side-effect Chinese medicinal materials as raw materials. Under the synergistic effect of various components, the Chinese medicine composition not only has obvious lipid-lowering and obesity-treating effects, but also can be brewed as tea, has no toxic and side effects, can be taken for a long time, and is suitable for people with obesity, hypertension, hyperlipidemia, edema, dizziness, constipation and the like. DETAILED DESCRIPTION

[0016] In order to make the purpose, technical scheme and advantages of the present invention clearer, the technical scheme in the embodiment of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present invention. The process parameters of the following embodiments that do not specify specific conditions are usually based on conventional conditions.

[0017] The endpoints and any values ​​of the ranges disclosed in the present invention are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be regarded as specifically disclosed in the present invention.

[0018] According to a first aspect of the present invention, a traditional Chinese medicine composition for treating obesity is provided, characterized in that 20-30 parts (e.g., 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts) of Artemisia capillaris, 25-35 parts (e.g., 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts) of Lycium barbarum, 10-20 parts (e.g., 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts) of processed Polygonum multiflorum, 15-25 parts (e.g., 15 parts, 1 10-20 portions (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20), 30-40 portions (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40), 2-5 portions (such as 2, 3, 4, 5) of senna leaves, and 5-15 portions (such as 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15) of hawthorn.

[0019] The medicinal compatibility principles of the Chinese medicine composition for treating obesity of the present invention are as follows:

[0020] Sovereign drug: processed Polygonum multiflorum and Atractylodes lancea are both sovereign drugs. Processed Polygonum multiflorum has the effects of nourishing the liver and kidneys and moistening the intestines and relieving constipation. Using processed Polygonum multiflorum as the sovereign drug can enhance the function of the internal organs, normalize the body's metabolic function, and reduce obesity caused by abnormal metabolic function. Atractylodes lancea can dry dampness and strengthen the spleen, improve the spleen and stomach's transportation and transformation, and reduce the formation of phlegm and dampness. It is used as the sovereign drug together with processed Polygonum multiflorum to treat obesity caused by liver and spleen disharmony and spleen and stomach dampness stagnation. Atractylodes lancea and Polygonum multiflorum are used as sovereign drugs together, which can also regulate the body's lipid metabolism and the overall balance of internal organs, promote the restoration of normal physiological functions, and thus achieve the purpose of treating obesity.

[0021] Minister drugs: Artemisia capillaris, wax gourd peel, and senna leaf are minister drugs. Artemisia capillaris has the effect of clearing heat, promoting dampness and promoting bile secretion, and has a good therapeutic effect on obesity with internal liver and gallbladder dampness and heat. Wax gourd peel and senna leaf both have the effect of clearing heat, promoting diuresis, strengthening the spleen and removing stagnation, and work together on the spleen, stomach and intestines. The three herbs are minister drugs. First, they enhance the effect of promoting diuresis and removing dampness, assist the monarch drug to further strengthen the removal of moisture and excess water in the body, promote water metabolism, reduce edema, and improve obesity-related symptoms caused by water stagnation. Second, they cooperate in laxative and purging turbidity: assist the monarch drug, jointly play the function of clearing the bowels and purging turbidity, promote the discharge of metabolic waste and toxins in the intestines, and reduce the absorption of harmful substances by the intestines. Third, they assist in clearing heat and purging fire: assist the monarch drug to remove the heat evil in the body and improve the metabolic disorders caused by internal heat. Fourth, they regulate the balance of the internal environment: through their respective effects, they coordinately adjust the water balance, metabolic balance and intestinal function in the body, creating favorable conditions for the monarch drug to play its main therapeutic role.

[0022] Auxiliary drugs: Hawthorn and wolfberry are adjuvant drugs. First, they can coordinately regulate the spleen, stomach, liver and kidney: Hawthorn focuses on regulating the digestive function of the spleen and stomach, while wolfberry focuses on nourishing the liver and kidney, and they work together to assist the main drug in improving the dysfunction of the internal organs related to obesity. Second, they can take into account both elimination and supplementation: Hawthorn has the effect of eliminating accumulation, while wolfberry has the function of nourishing. One eliminates and one supplements, so that the prescription can not only eliminate the accumulation in the body, but also replenish the nutrients and energy needed by the body, avoiding excessive attack and damaging the positive energy, and restricting the potency of the monarch and minister drugs in the prescription. Third, it can improve metabolism: through the comprehensive conditioning of the spleen, stomach, liver, kidney and other internal organs, it promotes the metabolism of substances and energy conversion in the body, which helps to achieve the purpose of weight loss and lipid reduction. They all have the effects of clearing away heat, promoting water, strengthening the spleen and removing stagnation, and work together on the spleen and stomach meridians.

[0023] Assistant drug: Bupleurum in the prescription is the assistant drug, which can relieve liver depression, regulate Qi, lead the meridians and report to the assistant drug, and guide the various drugs in the prescription to the diseased area, so that the efficacy of each drug in the prescription can be smoothly exerted and avoid Qi stagnation affecting the efficacy of the drugs.

[0024] The conventional effects of the Chinese medicinal materials selected in the present invention are as follows:

[0025] Artemisia capillaris: pungent, slightly cold in nature, enters the spleen, stomach, liver, and gallbladder meridians; has the effects of clearing away dampness and heat, promoting bile secretion and relieving jaundice;

[0026] Lycium barbarum: sweet, flat; enters the liver and kidney meridians; has multiple pharmacological effects such as enhancing immunity, delaying aging, resisting liver damage, lowering blood sugar, lowering blood lipids, sex hormone-like, and anti-fatigue;

[0027] Prepared Polygonum multiflorum: bitter, sweet, astringent, warm; enters the liver, heart, and kidney meridians; has the effects of nourishing the liver and kidneys, replenishing essence and blood, clearing turbidity and reducing lipids;

[0028] Bupleurum: slightly cold, bitter and pungent; enters the liver meridian, gallbladder meridian, and lung meridian; has the effects of reconciling the exterior and interior, soothing the liver and relieving depression, raising yang and lifting depression, and reducing fever and stopping malaria;

[0029] Atractylodes: pungent and warm, bitter in taste; enters the spleen, stomach, and liver meridians; has the effects of drying dampness, strengthening the spleen, dispelling wind and cold, and improving eyesight;

[0030] Winter melon peel: sweet in taste, slightly cold in nature; enters the lung meridian, spleen meridian, and small intestine meridian; has the effects of clearing heat, promoting diuresis, and reducing swelling;

[0031] Senna leaves: sweet, bitter, cold; enter the large intestine meridian; have the effects of purging heat and removing stagnation, treating constipation due to heat accumulation, abdominal distension due to stagnation, etc.

[0032] Hawthorn: slightly warm in nature, sour and sweet in taste; enters the spleen, stomach, and liver meridians; has the functions of helping digestion and strengthening the stomach, promoting blood circulation and removing blood stasis, and astringing and stopping diarrhea.

[0033] The weight parts of the present invention mainly include the disclosed numerical range, any numerical value (including integer and decimal) or any interval of two numerical values ​​in the disclosed range, or multiple discontinuous intervals, and also include numerical values ​​or numerical ranges close to the end value of the numerical range whose effects can be expected to be similar, such as 5-10 parts, not only including 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and any interval of two parts, for other numerical ranges, not exemplified one by one, all are included in the present invention. Therefore, the present invention also includes the sub-range of any numerical range that has been directly disclosed or any specific numerical value therein.

[0034] In order to further optimize the effect of the Chinese medicine composition for treating obesity, the present invention studies the influence of different proportions of various raw medicinal materials on their efficacy, and obtains the better and more optimal proportions of the Chinese medicine composition for treating obesity, wherein the better proportion of the Chinese medicine composition for treating obesity is: 22-28 parts of Artemisia capillaris, 28-32 parts of Lycium barbarum, 12-18 parts of processed Polygonum multiflorum, 18-22 parts of Bupleurum, 12-18 parts of Atractylodes lancea, 32-38 parts of wax gourd peel, 3-4 parts of senna leaves, and 8-12 parts of hawthorn. The better proportion of the Chinese medicine composition for treating obesity is: 25 parts of Artemisia capillaris, 30 parts of Lycium barbarum, 15 parts of processed Polygonum multiflorum, 20 parts of Bupleurum, 15 parts of Atractylodes lancea, 35 parts of wax gourd peel, 3.5 parts of senna leaves, and 10 parts of hawthorn.

[0035] According to the second aspect of the present invention, a method for preparing the above-mentioned Chinese medicine composition for treating obesity is also provided, comprising the following steps: weighing each component by weight, mixing and then crushing through an 80-100 mesh sieve to obtain a powdered Chinese medicine composition for treating obesity.

[0036] After the raw materials of each component are crushed or cut into thin wires or small pieces, the surface area is increased, and the contact area with the solvent is increased, and the active ingredients of the medicine are easier to dissolve after decoction.

[0037] In the preparation method of the above scheme, as a preferred embodiment, it also includes decocting the powdered Chinese medicine composition for treating obesity with water, wherein the amount of water added is 4 times the weight of the composition, and the decocting time is 15 to 20 minutes, to obtain a decoction of the Chinese medicine composition for treating obesity.

[0038] The Chinese medicine composition for treating obesity of the present invention can be directly brewed with boiling water or slightly boiled before drinking, thereby avoiding the loss of effective ingredients of the medicine due to processing, long-term boiling and long-term boiling of the decoction; on the other hand, brewing the medicine with boiling water can quickly degrade and inactivate the enzyme therein, thereby avoiding the decomposition and destruction of the effective ingredients. Experiments show that: first, antipyretic medicines mostly contain volatile oils, which can volatilize at room temperature; second, when the temperature of the medicine liquid is 30-40°C, the enzyme activity contained in the medicine is very strong, and the effective ingredients of the medicine, especially the glycoside components, are easily decomposed under the action of the enzyme.

[0039] According to the second aspect of the present invention, there is also provided the use of the above-mentioned traditional Chinese medicine composition for treating obesity in the preparation of a product for treating obesity.

[0040] In the above application, the product for treating obesity is a weight loss health tea.

[0041] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] Example 1

[0043] This embodiment provides a Chinese medicine composition for treating obesity, and the weight proportions of the raw medicinal materials are as follows: 25 parts of Artemisia capillaris, 30 parts of Lycium barbarum, 15 parts of processed Polygonum multiflorum, 20 parts of Bupleurum, 15 parts of Atractylodes lancea, 35 parts of Wax gourd peel, 3.5 parts of Senna leaves, and 10 parts of Crataegus pinnatifida.

[0044] The preparation method of the Chinese medicine composition for treating obesity in this embodiment is as follows:

[0045] Weigh each component by weight, mix and crush through a 100-mesh sieve to obtain a powdered Chinese medicine composition for treating obesity; add water to the powdered Chinese medicine composition for treating obesity and boil it in an amount of 4 times the weight of the composition for 18 minutes to obtain the decoction Chinese medicine composition of this embodiment.

[0046] Example 2

[0047] This embodiment provides a Chinese medicine composition for treating obesity, and the weight proportions of each raw medicinal material are as follows:

[0048] 20 parts of Artemisia capillaris, 25 parts of wolfberry fruits, 10 parts of processed Polygonum multiflorum, 15 parts of bupleurum, 10 parts of atractylodes, 30 parts of wax gourd peels, 2 parts of senna leaves, and 5 parts of hawthorn.

[0049] The preparation method of the Chinese medicine composition for treating obesity in this embodiment is as follows:

[0050] Weigh each component by weight, mix and then crush through an 80-mesh sieve to obtain a powdered Chinese medicine composition for treating obesity; add water to the powdered Chinese medicine composition for treating obesity and boil it, the amount of water added is 4 times the weight of the composition, and the boiling time is 15 minutes to obtain the decoction Chinese medicine composition of this embodiment.

[0051] Example 3

[0052] This embodiment provides a traditional Chinese medicine composition for treating obesity, wherein the weight proportions of the raw medicinal materials are as follows: 30 parts of Artemisia capillaris, 35 parts of Lycium barbarum, 20 parts of processed Polygonum multiflorum, 25 parts of Bupleurum, 20 parts of Atractylodes lancea, 40 parts of Wax gourd peel, 5 parts of Senna leaves, and 15 parts of Crataegus pinnatifida.

[0053] The preparation method of the Chinese medicine composition for treating obesity in this embodiment is as follows:

[0054] Weigh each component by weight, mix and crush, and pass through a 100-mesh sieve to obtain a powdered Chinese medicine composition for treating obesity; add water to the powdered Chinese medicine composition for treating obesity and boil it, the amount of water added is 4 times the weight of the composition, and the boiling time is 20 minutes to obtain the decoction Chinese medicine composition of this embodiment.

[0055] In order to demonstrate the effect of the Chinese medicine composition for treating wind-heat cold of the present invention, the following typical cases are selected for illustration. The Chinese medicine composition taken is the decoction prepared in Example 1.

[0056] Case 1: Du, male, 60 years old, originally weighed 76 kg. After increasing to 95 kg, he took 150 ml of decoction twice a day, once before breakfast and dinner, for three months. He lost 2 kg in the first month and 6.7 kg in three months. He did not feel tired during the period. His skin became tight and not loose after losing weight. He paid attention to diet control in the later period, and there was no rebound phenomenon after one year.

[0057] Case 2: Zhang, female, 56 years old, originally weighed 60 kg, usually liked milk tea, and later increased to 79 kg. She took 150 ml of decoction each time, twice a day, once before breakfast and dinner. During the period of taking it, she mainly ate lean meat, vegetables, coarse grains and nuts. After taking it for one month, she lost 5.2 kg, after two months of eye use, she lost 3 kg, and after three months of taking it, she continued to lose 2 kg. No adverse reactions such as fatigue and diarrhea occurred during the period, and the skin was firm and not loose after losing weight; pay attention to diet control in the later period, and there was no rebound phenomenon after one year.

[0058] Case 3: Dai, female, 46 years old, congenitally obese, usually likes sweets, height 156 cm, original weight 70 kg, took decoction 100 ml each time, three times a day, once after breakfast, lunch and dinner, and took vegetables, rice porridge, fruits and other staple foods during the period of taking. After taking it for 50 days, the weight dropped to 64.2 kg, and no adverse reactions such as fatigue and abdominal pain occurred during the period. After losing weight, the skin was firm and not loose; pay attention to diet control in the later period, and there was no rebound phenomenon after one year.

[0059] The above describes and evaluates the efficacy of some embodiments of the present invention. It should be understood that the present invention is not limited to the above specific implementations. Any technician familiar with the art can use the above disclosed methods and technical contents to make many possible changes and modifications to the technical solutions of the present invention without departing from the scope of the technical solutions of the present invention, or modify them into equivalent embodiments of equivalent changes, which does not affect the essential content of the present invention. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solutions of the present invention still falls within the scope of protection of the technical solutions of the present invention.

Claims

1. A Chinese medicine composition for treating obesity, characterized in that: The invention comprises the following components by weight: 20-30 parts of Artemisia capillaris, 25-35 parts of Lycium barbarum, 10-20 parts of processed Polygonum multiflorum, 15-25 parts of Bupleurum chinense, 10-20 parts of Atractylodes lancea, 30-40 parts of wax gourd peel, 2-5 parts of senna leaves and 5-15 parts of hawthorn.

2. The Chinese medicine composition for treating obesity according to claim 1, characterized in that: The invention comprises the following components by weight: 22-28 parts of Artemisia capillaris, 28-32 parts of Lycium barbarum, 12-18 parts of processed Polygonum multiflorum, 18-22 parts of Bupleurum chinense, 12-18 parts of Atractylodes lancea, 32-38 parts of wax gourd peel, 3-4 parts of senna leaves and 8-12 parts of hawthorn.

3. The Chinese medicine composition for treating obesity according to claim 1, characterized in that: The invention comprises the following components by weight: 25 parts of Artemisia capillaris, 30 parts of wolfberry, 15 parts of processed Polygonum multiflorum, 20 parts of Bupleurum chinense, 15 parts of Atractylodes lancea, 35 parts of wax gourd peel, 3.5 parts of senna leaves and 10 parts of hawthorn.

4. The method for preparing the Chinese medicine composition for treating obesity according to any one of claims 1 to 3, characterized in that: The following steps are involved: The components are weighed according to weight, mixed and then crushed to pass through a 80-100 mesh sieve to obtain a powdered Chinese medicine composition for treating obesity.

5. The preparation method according to claim 4, characterized in that: The method also includes decocting the powdered Chinese medicine composition for treating obesity with water, wherein the amount of water added is 4 times the weight of the composition, and the decocting time is 15 to 20 minutes, to obtain a decoction of the Chinese medicine composition for treating obesity.

6. Use of the Chinese medicine composition for treating obesity according to any one of claims 1 to 3 in preparing a product for treating obesity.

7. The use according to claim 6, characterized in that: The product for treating obesity is a slimming health tea.