Moisturizing and whitening skin cream and preparation method thereof
By using rice polypeptides, acetylated mannosamine and amino-β-cyclodextrin in hydrating and whitening skin cream, combined with grapefruit extract and raspberry ketoglucoside, the problem of poor stability of plant extracts was solved, significantly Improves the deep moisturizing and whitening effects of skin care creams, meeting the needs of healthy skin.
Patent Information
- Application Number
- CN202411432530.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-14
- Publication Date
- 2024-12-27
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing hydrating and whitening skin creams have poor stability, and the skin's water retention ability, especially the deep water retention ability, has insufficient, resulting in average use effect.
Rice complexes are prepared by enzymatic lysis technology using rice polypeptides, acetylated mannosamine and amino-β-cyclodextrin, and combined with grapefruit extract and raspberry ketoglycoside to form a stable complex to enhance Antioxidant, anti-inflammatory and whitening effects of the skin improve deep water retention.
The synergistic effect of rice peptides and grapefruit extract significantly improves the anti-aging, whitening and moisturizing effect of skin cream, enhances the deep moisturizing ability of the skin, meets consumers' pursuit of healthy skin, and improves the safety of the product and User experience.
Smart Images
Figure BDA0005084042710000141
Abstract
Description
Technical Field
[0001] The invention relates to the technical field of skin care creams, in particular to a moisturizing and whitening skin care cream and a preparation method thereof. Background Art
[0002] Skin care cream is one of the most popular product categories in the modern skin care market. Its original design intention is to meet consumers' skin protection needs. With the development of the times, manufacturers have begun to provide skin whitening and moisturizing effects on the basis of improving skin care effects to improve product competitiveness. As the concept of healthy skin care has become more popular, more and more consumers have begun to pay attention to the safety and effectiveness of product ingredients, which has provided a new direction for the development of moisturizing and whitening skin care creams, that is, using green natural plants to replace the original ingredients. However, in the existing technology, plant extracts may have poor stability and poor skin water retention capacity, especially poor deep water retention capacity, and the effect of adding whitening and moisturizing skin care creams is average.
[0003] In summary, in order to solve the above problems, it is of great significance to prepare a hydrating and whitening skin cream. Summary of the invention
[0004] The purpose of the present invention is to provide a moisturizing and whitening skin cream to solve the problems raised in the prior art.
[0005] To achieve the above object, the present invention provides the following technical solutions:
[0006] A moisturizing and whitening skin cream comprises the following raw materials, calculated in 120 parts by mass: 9 to 14 parts of an oil phase, 10.5 to 16.5 parts of an aqueous phase, 0.6 to 1.2 parts of an additive, 6 to 10 parts of a plant extract, and the remainder being deionized water.
[0007] Preferably, the oil phase includes the following substances, in parts by mass: 4 to 5 parts of olive oil, 2 to 3 parts of dimethicone, 1 to 2 parts of cetyl alcohol, 1 to 2 parts of stearyl alcohol, and 1 to 2 parts of polyglyceryl-10 stearate.
[0008] Preferably, the aqueous phase includes the following substances, in parts by mass: 1 to 1.5 parts of xanthan gum, 5 to 7 parts of glycerin, 2 to 3 parts of 1,3-butylene glycol, 1 to 2 parts of glyceryl stearate, 1 to 2 parts of ceteareth-20, and 0.5 to 1 part of disodium ethylenediaminetetraacetic acid.
[0009] Preferably, the additives include the following substances, calculated by weight: 0.5-1 parts of flavor, 0.05-0.1 parts of phenoxyethanol, and 0.05-0.1 parts of methylparaben.
[0010] Preferably, the plant extract comprises the following substances, calculated by mass: 2 to 3 parts of rice complex, 2 to 3 parts of grapefruit extract, 1 to 2 parts of dipotassium glycyrrhizinate, and 1 to 2 parts of raspberry ketone glucoside.
[0011] Preferably, the method for preparing the rice composite comprises the following steps:
[0012] (1) Add anhydrous N-acetyl-D-mannosamine, acetic anhydride, and anhydrous sodium acetate into a flask, stir and reflux at 140-145° C. for 2-3 hours, cool to 0-5° C. to precipitate crystals, filter, purify, wash, and vacuum dry at 50-55° C. for 3-4 hours to obtain acetylated mannosamine;
[0013] (2) grinding the rice through a 800-1000 mesh sieve, adding it to 80-90 parts of deionized water, uniformly dispersing it by ultrasonication, adjusting the pH to 9-11, stirring it at 50-55° C. for 1.5-2 hours, cooling it to 45-50° C., then adding alkaline protease, stirring it uniformly, keeping it warm for 3-4 hours, heating it to 80-90° C. and stirring it for 15-20 minutes, cooling it to room temperature, adjusting the pH to 6-7, centrifuging it at 4000-5000 r / min for 20-30 minutes, taking the supernatant, concentrating it under reduced pressure, and freeze-drying it to obtain rice polypeptide;
[0014] (3) Add rice polypeptide, acetylated mannosamine and activator into deionized water, stir evenly at 40-50° C., then add 6-amino-β-cyclodextrin, stir at 45-50° C. for 3-4 hours, filter, wash and dry to obtain a rice complex.
[0015] The acetylated mannosamine comprises the following raw materials in parts by weight: 2 to 3 parts of anhydrous N-acetyl-D-mannosamine, 7 to 8 parts of acetic anhydride, and 0.4 to 0.6 parts of anhydrous sodium acetate; the rice polypeptide comprises the following raw materials in parts by weight: 9 to 11 parts of rice and 0.2 to 0.4 parts of alkaline protease; the rice complex comprises the following raw materials in parts by weight: 8 to 10 parts of rice polypeptide, 3 to 5 parts of acetylated mannosamine, 3 to 4 parts of activator, and 4 to 5 parts of 6-amino-β-cyclodextrin.
[0016] Preferably, the rice is Northeastern rice, which is commercially available.
[0017] Wherein, the alkaline protease is Novo protease; the activator comprises 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and N-hydroxysuccinimide in a mass ratio of 1:1.5.
[0018] Preferably, the method for preparing the grapefruit extract comprises the following steps:
[0019] (1) Clean fresh grapefruit peel, put it in an oven at 70-80° C. and dry it for 20-22 hours, take it out, cut it into small pieces, grind it, and pass it through a 200-400 mesh sieve to obtain grapefruit peel powder;
[0020] (2) Add 40-50 parts of anhydrous ethanol to grapefruit peel powder, ultrasonicate at 200-300 W at 40-50° C. for 2-3 h, centrifuge at 7000-8000 r / min for 15-20 min, collect the supernatant, concentrate under reduced pressure, and freeze-dry to obtain a grapefruit extract.
[0021] The grapefruit peel powder comprises the following raw materials in parts by mass: 20 to 30 parts of fresh grapefruit peel; and the grapefruit extract comprises the following raw materials in parts by mass: 3 to 5 parts of grapefruit peel powder.
[0022] Preferably, the grapefruit peel is obtained by peeling red grapefruit and is commercially available.
[0023] Preferably, the method for preparing the moisturizing and whitening skin cream comprises the following steps:
[0024] S1: Add the aqueous phase to deionized water, stir at 70-80°C for 1-2h, then slowly add the oil phase, stir for 20-30min, and homogenize to obtain raw material A;
[0025] S2: After the raw material A is cooled to 40-45°C, the additive is slowly added, stirred for 20-30 minutes, and homogenized to obtain the raw material B;
[0026] S3: After the raw material B is cooled to 35-40°C, the plant extract is slowly added, stirred for 20-30 minutes, deionized water is added to make the total number of raw materials reach 120 parts, and homogenization is performed to obtain a whitening and moisturizing skin cream. Compared with the prior art, the beneficial effects of the present invention include the following aspects:
[0027] (1) Rice polypeptide is a small molecule polypeptide substance obtained by enzymatic hydrolysis using rice protein as raw material. It is rich in nutrients such as peptide molecule mixture, amino acids, sugars, water and inorganic salts. After being added to skin cream, it is easily absorbed by the surface skin, promotes skin health, improves the skin's antioxidant capacity, reduces the appearance of wrinkles and fine lines, and thus plays an anti-aging role. It can remove free radicals, increase the activity of superoxide dismutase, reduce the activity of tyrosinase, and improve the whitening effect. Rice polypeptide is also hypoallergenic, making it an ideal ingredient in cosmetics, especially suitable for sensitive skin. By introducing acetylated mannosamine, its moisture absorption and water retention can be further improved, the skin's moisturizing ability can be improved, and the product's moisturizing effect can be improved. At the same time, acetylated mannosamine helps to enhance the skin barrier function, reduce the stimulation and damage of the external environment to the skin, promote the metabolic activity of skin cells, accelerate the shedding of the aging stratum corneum, and make the skin smoother and more delicate. Amino-β-cyclodextrin has a very strong molecular inclusion effect. After being grafted with rice polypeptide, it can effectively wrap the rice polypeptide and acetylated mannosamine to form a stable complex to improve the activity and stability of the rice polypeptide. When on the skin surface, it helps to assist the rice polypeptide to enter the deep layer of the skin and improve the whitening effect. In addition, the polyhydroxy structure can preserve a large amount of water and improve the water retention effect in the deep layer of the skin.
[0028] (2) Raspberry ketone glucoside is an excellent nitric oxide scavenger that can effectively eliminate excess nitric oxide in the skin. Nitric oxide is synthesized in the skin by nitric oxide synthase, which can cause rough skin and aging, and is one of the main causes of pigmentation. By reducing the content of nitric oxide, raspberry ketone glucoside can reduce the activity of tyrosinase, thereby reducing the formation of melanin and achieving a whitening effect. The combination of raspberry extract and rice peptide can produce a synergistic effect to enhance the product's antioxidant, anti-inflammatory and whitening effects. The antioxidant and anti-inflammatory properties of raspberry ketone glucoside may help enhance the anti-aging effect of rice peptides, while the moisturizing and whitening properties of rice peptides may further enhance the skin care effect of ketone glucoside. This synergistic effect helps to improve the effectiveness of skin care products while making them safer to use, satisfying consumers' pursuit of healthy skin.
[0029] (3) Grapefruit peel is rich in flavonoids, which have antioxidant and melanin-inhibiting effects, helping to reduce spots and dullness, brighten skin tone, deeply moisturize the skin, and enhance the skin's water retention capacity, thereby improving dry skin and making the skin more hydrated. When raspberry ketone glucoside is used together with rice peptides, the two can work synergistically to further enhance the whitening effect. The penetration-promoting effect of rice peptides can help grapefruit extract better penetrate into the deep layers of the skin, thereby exerting a more comprehensive whitening and skin care effect. DETAILED DESCRIPTION
[0030] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present invention.
[0031] It should be noted that there are no special restrictions on the purchase manufacturers of all the raw materials involved in the present invention, and exemplarily include: cetyl alcohol, purity 99%, provided by Hubei Yongkuo Technology Co., Ltd.; stearyl alcohol, purity 99%, provided by Hubei Yongkuo Technology Co., Ltd.; polyglycerol-10 stearate, purity 99%, provided by Jinjinle (Hunan) Chemical Co., Ltd.; xanthan gum, purity 99%, provided by Hubei Jusheng Technology Co., Ltd.; glyceryl stearate, purity 99%, provided by Hubei Yongkuo Technology Co., Ltd.; cetearyl alcohol polyether-20, purity 99%, provided by Hebei Zhentian Food Additive Co., Ltd.; disodium ethylenediaminetetraacetic acid, purity 99%, provided by Hebei Zhentian Food Additive Co., Ltd.; N-acetyl-D-mannosamine, purity 98%, provided by JACS-Zhengzhou Jacks Chemical Products Co., Ltd.; 6-amino-β-cyclodextrin, purity 98%, provided by (Alpha) Zhengzhou Huiju Chemical Co., Ltd.
[0032] In the following examples, parts are by mass, and raw materials are all commercially available.
[0033] Embodiment 1:
[0034] Step 1: Preparation of rice complex: (1) Add 2.5 parts of anhydrous N-acetyl-D-mannosamine, 7.5 parts of acetic anhydride, and 0.5 parts of anhydrous sodium acetate into a flask, stir and reflux at 140°C for 2.5 hours, cool to 1°C to precipitate crystals, filter the crystals, purify, wash, and vacuum dry at 50°C for 3.5 hours to obtain acetylated mannosamine; (2) Grind 10 parts of rice through a 1000 mesh sieve, add to 85 parts of deionized water, disperse evenly with ultrasound, adjust the pH to 10, stir at 50°C for 1.5 hours, cool to 45°C, and then Then, 0.3 parts of alkaline protease was added, stirred evenly, kept warm for 3.5 hours, heated to 85°C and stirred for 15 minutes, lowered to room temperature, adjusted to pH 6, centrifuged at 5000 r / min for 30 minutes, took the supernatant, concentrated under reduced pressure, and freeze-dried to obtain rice polypeptide; (3) 9 parts of rice polypeptide, 4 parts of acetylated mannosamine and 3.5 parts of activator were added to 75 parts of deionized water, stirred evenly at 40°C, then 4.5 parts of 6-amino-β-cyclodextrin were added, stirred at 45°C for 3.5 hours, filtered, washed, and dried to obtain a rice complex;
[0035] Step 2: Preparation of grapefruit extract: (1) Wash 25 parts of fresh grapefruit peel, put it in an oven at 75°C and dry it for 20 hours, take it out and cut it into small pieces, grind it, and pass it through a 200-grit sieve to obtain grapefruit peel powder; (2) Add 45 parts of anhydrous ethanol to 4 parts of grapefruit peel powder, ultrasonicate it at 200 W power at 45°C for 2.5 hours, centrifuge it at 7000 r / min for 15 minutes, take the supernatant, concentrate it under reduced pressure, and freeze-dry it to obtain grapefruit extract;
[0036] Step 3: Preparation of whitening and moisturizing skin cream:
[0037] S1: 13 parts of aqueous phase (1 part of xanthan gum, 6 parts of glycerin, 2.5 parts of 1,3-butylene glycol, 1.3 parts of glyceryl stearate, 1.5 parts of cetearyl alcohol polyether-20, 0.7 parts of disodium edetate) were added to 45 parts of deionized water, stirred at 75°C for 1.5 hours, and then 11.5 parts of oil phase (4.5 parts of olive oil, 2.5 parts of dimethicone, 1.5 parts of cetyl alcohol, 1.4 parts of stearyl alcohol, 1.6 parts of polyglyceryl-10 stearate) were slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material A;
[0038] S2: After the raw material A is cooled to 40°C, 0.6 parts of additives (0.5 parts of flavor, 0.05 parts of phenoxyethanol, and 0.05 parts of methylparaben) are slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material B;
[0039] S3: After the raw material B is cooled to 35°C, 8 parts of plant extracts (2.5 parts of rice complex, 2.5 parts of grapefruit extract, 1.5 parts of dipotassium glycyrrhizinate, and 1.5 parts of raspberry ketone glucoside) are slowly added, stirred for 20 to 30 minutes, and deionized water is added to make the total number of raw materials reach 120 parts. After homogenization, a whitening and moisturizing skin cream is obtained.
[0040] Embodiment 2:
[0041] Step 1: Preparation of rice complex: (1) Add 2.5 parts of anhydrous N-acetyl-D-mannosamine, 7.5 parts of acetic anhydride, and 0.5 parts of anhydrous sodium acetate into a flask, stir and reflux at 140°C for 2.5 hours, cool to 1°C to precipitate crystals, filter the crystals, purify, wash, and vacuum dry at 50°C for 3.5 hours to obtain acetylated mannosamine; (2) Grind 10 parts of rice through a 1000 mesh sieve, add to 85 parts of deionized water, disperse evenly with ultrasound, adjust the pH to 10, stir at 50°C for 1.5 hours, cool to 45°C, and then Then, 0.3 parts of alkaline protease was added, stirred evenly, kept warm for 3.5 hours, heated to 85°C and stirred for 15 minutes, lowered to room temperature, adjusted to pH 6, centrifuged at 5000 r / min for 30 minutes, took the supernatant, concentrated under reduced pressure, and freeze-dried to obtain rice polypeptide; (3) 9 parts of rice polypeptide, 4 parts of acetylated mannosamine and 3.5 parts of activator were added to 75 parts of deionized water, stirred evenly at 40°C, then 4.5 parts of 6-amino-β-cyclodextrin were added, stirred at 45°C for 3.5 hours, filtered, washed, and dried to obtain a rice complex;
[0042] Step 2: Preparation of grapefruit extract: (1) Wash 25 parts of fresh grapefruit peel, put it in an oven at 75°C and dry it for 20 hours, take it out and cut it into small pieces, grind it, and pass it through a 200-grit sieve to obtain grapefruit peel powder; (2) Add 45 parts of anhydrous ethanol to 4 parts of grapefruit peel powder, ultrasonicate it at 200 W power at 45°C for 2.5 hours, centrifuge it at 7000 r / min for 15 minutes, take the supernatant, concentrate it under reduced pressure, and freeze-dry it to obtain grapefruit extract;
[0043] Step 3: Preparation of whitening and moisturizing skin cream:
[0044] S1: Add 10.5 parts of aqueous phase (1 part of xanthan gum, 5 parts of glycerin, 2 parts of 1,3-butylene glycol, 1 part of glyceryl stearate, 1 part of cetearyl alcohol polyether-20, 0.5 part of disodium edetate) to 40 parts of deionized water, stir at 70°C for 1 hour, then slowly add 9 parts of oil phase (4 parts of olive oil, 2 parts of dimethicone, 1 part of cetyl alcohol, 1 part of stearyl alcohol, 1 part of polyglyceryl-10 stearate), stir for 20 to 30 minutes, and homogenize to obtain raw material A;
[0045] S2: After the raw material A is cooled to 40°C, 0.6 to 1.2 parts of additives (0.5 parts of flavor, 0.05 parts of phenoxyethanol, and 0.05 parts of methylparaben) are slowly added, stirred for 20 minutes, and homogenized to obtain raw material B;
[0046] S3: After the raw material B is cooled to 35°C, 6 parts of plant extracts (2 parts of rice complex, 2 parts of grapefruit extract, 1 part of dipotassium glycyrrhizinate, 1 part of raspberry ketone glucoside) are slowly added, stirred for 20 minutes, and deionized water is added to make the total number of raw materials reach 120 parts. After homogenization, a whitening and moisturizing skin cream is obtained.
[0047] Embodiment 3:
[0048] Step 1: Preparation of rice complex: (1) Add 2.5 parts of anhydrous N-acetyl-D-mannosamine, 7.5 parts of acetic anhydride, and 0.5 parts of anhydrous sodium acetate into a flask, stir and reflux at 140°C for 2.5 hours, cool to 1°C to precipitate crystals, filter the crystals, purify, wash, and vacuum dry at 50°C for 3.5 hours to obtain acetylated mannosamine; (2) Grind 10 parts of rice through a 1000 mesh sieve, add to 85 parts of deionized water, disperse evenly with ultrasound, adjust the pH to 10, stir at 50°C for 1.5 hours, cool to 45°C, and then Then, 0.3 parts of alkaline protease was added, stirred evenly, kept warm for 3.5 hours, heated to 85°C and stirred for 15 minutes, lowered to room temperature, adjusted to pH 6, centrifuged at 5000 r / min for 30 minutes, took the supernatant, concentrated under reduced pressure, and freeze-dried to obtain rice polypeptide; (3) 9 parts of rice polypeptide, 4 parts of acetylated mannosamine and 3.5 parts of activator were added to 75 parts of deionized water, stirred evenly at 40°C, then 4.5 parts of 6-amino-β-cyclodextrin were added, stirred at 45°C for 3.5 hours, filtered, washed, and dried to obtain a rice complex;
[0049] Step 2: Preparation of grapefruit extract: (1) Wash 25 parts of fresh grapefruit peel, put it in an oven at 75°C and dry it for 20 hours, take it out and cut it into small pieces, grind it, and pass it through a 200-grit sieve to obtain grapefruit peel powder; (2) Add 45 parts of anhydrous ethanol to 4 parts of grapefruit peel powder, ultrasonicate it at 200 W power at 45°C for 2.5 hours, centrifuge it at 7000 r / min for 15 minutes, take the supernatant, concentrate it under reduced pressure, and freeze-dry it to obtain grapefruit extract;
[0050] Step 3: Preparation of whitening and moisturizing skin cream:
[0051] S1: Add 16.5 parts of aqueous phase (1.5 parts of xanthan gum, 7 parts of glycerin, 3 parts of 1,3-butylene glycol, 2 parts of glyceryl stearate, 2 parts of cetearyl alcohol polyether-20, 1 part of disodium edetate) to 50 parts of deionized water, stir at 80°C for 2h, then slowly add 14 parts of oil phase (5 parts of olive oil, 3 parts of dimethicone, 2 parts of cetyl alcohol, 2 parts of stearyl alcohol, 2 parts of polyglyceryl-10 stearate), stir for 30min, and homogenize to obtain raw material A;
[0052] S2: After the raw material A is cooled to 45°C, 1.2 parts of additives (1 part of flavor, 0.1 part of phenoxyethanol, and 0.1 part of methylparaben) are slowly added, stirred for 30 minutes, and homogenized to obtain raw material B;
[0053] S3: After the raw material B is cooled to 40°C, 10 parts of plant extracts (3 parts of rice complex, 3 parts of grapefruit extract, 2 parts of dipotassium glycyrrhizinate, 2 parts of raspberry ketone glucoside) are slowly added, stirred for 30 minutes, and deionized water is added to make the total number of raw materials reach 120 parts. After homogenization, a whitening and moisturizing skin cream is obtained.
[0054] Comparative Example 1: Based on Example 1, the rice polypeptide was not modified and the other processes remained unchanged.
[0055] Step 1: (1) 10 parts of rice are crushed and passed through a 1000 mesh sieve, added to 85 parts of deionized water, and uniformly dispersed by ultrasonication. After adjusting the pH to 10, the mixture is stirred at 50° C. for 1.5 hours, cooled to 45° C., and then 0.3 parts of alkaline protease are added, stirred uniformly, kept warm for 3.5 hours, heated to 85° C. and stirred for 15 minutes, cooled to room temperature, adjusted the pH to 6, centrifuged at 5000 r / min for 30 minutes, and the supernatant is collected, concentrated under reduced pressure, and freeze-dried to obtain rice polypeptide;
[0056] Step 2: Preparation of grapefruit extract: (1) Wash 25 parts of fresh grapefruit peel, put it in an oven at 75°C and dry it for 20 hours, take it out and cut it into small pieces, grind it, and pass it through a 200-grit sieve to obtain grapefruit peel powder; (2) Add 45 parts of anhydrous ethanol to 4 parts of grapefruit peel powder, ultrasonicate it at 200 W power at 45°C for 2.5 hours, centrifuge it at 7000 r / min for 15 minutes, take the supernatant, concentrate it under reduced pressure, and freeze-dry it to obtain grapefruit extract;
[0057] Step 3: Preparation of whitening and moisturizing skin cream:
[0058] S1: 13 parts of aqueous phase (1 part of xanthan gum, 6 parts of glycerin, 2.5 parts of 1,3-butylene glycol, 1.3 parts of glyceryl stearate, 1.5 parts of cetearyl alcohol polyether-20, 0.7 parts of disodium edetate) were added to 45 parts of deionized water, stirred at 75°C for 1.5 hours, and then 11.5 parts of oil phase (4.5 parts of olive oil, 2.5 parts of dimethicone, 1.5 parts of cetyl alcohol, 1.4 parts of stearyl alcohol, 1.6 parts of polyglyceryl-10 stearate) were slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material A;
[0059] S2: After the raw material A is cooled to 40°C, 0.6 parts of additives (0.5 parts of flavor, 0.05 parts of phenoxyethanol, and 0.05 parts of methylparaben) are slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material B;
[0060] S3: After the raw material B is cooled to 35°C, 8 parts of plant extracts (2.5 parts of rice polypeptide, 2.5 parts of grapefruit extract, 1.5 parts of dipotassium glycyrrhizinate, and 1.5 parts of raspberry ketone glucoside) are slowly added, stirred for 20 to 30 minutes, and deionized water is added to make the total number of raw materials reach 120 parts. After homogenization, a whitening and moisturizing skin cream is obtained.
[0061] Comparative Example 2: Based on Example 1, the rice complex is not coated with cyclodextrin, and the other processes remain unchanged.
[0062] Step 1: Preparation of rice complex: (1) Add 2.5 parts of anhydrous N-acetyl-D-mannosamine, 7.5 parts of acetic anhydride, and 0.5 parts of anhydrous sodium acetate into a flask, stir and reflux at 140°C for 2.5 hours, cool to 1°C to precipitate crystals, filter the crystals, purify, wash, and vacuum dry at 50°C for 3.5 hours to obtain acetylated mannosamine; (2) Grind 10 parts of rice through a 1000 mesh sieve, add to 85 parts of deionized water, disperse evenly with ultrasound, adjust the pH to 10, and stir at 50°C. Stir for 1.5 hours, cool to 45°C, then add 0.3 parts of alkaline protease, stir evenly, keep warm for 3.5 hours, heat to 85°C and stir for 15 minutes, cool to room temperature, adjust the pH to 6, centrifuge at 5000r / min for 30 minutes, take the supernatant, concentrate under reduced pressure, and freeze-dry to obtain rice polypeptide; (3) add 9 parts of rice polypeptide, 4 parts of acetylated mannosamine and 3.5 parts of activator to 75 parts of deionized water, stir at 45°C for 3.5 hours, filter, wash, and dry to obtain a rice complex;
[0063] Step 2: Preparation of grapefruit extract: (1) Wash 25 parts of fresh grapefruit peel, put it in an oven at 75°C and dry it for 20 hours, take it out and cut it into small pieces, grind it, and pass it through a 200-grit sieve to obtain grapefruit peel powder; (2) Add 45 parts of anhydrous ethanol to 4 parts of grapefruit peel powder, ultrasonicate it at 200 W power at 45°C for 2.5 hours, centrifuge it at 7000 r / min for 15 minutes, take the supernatant, concentrate it under reduced pressure, and freeze-dry it to obtain grapefruit extract;
[0064] Step 3: Preparation of whitening and moisturizing skin cream:
[0065] S1: 13 parts of aqueous phase (1 part of xanthan gum, 6 parts of glycerin, 2.5 parts of 1,3-butylene glycol, 1.3 parts of glyceryl stearate, 1.5 parts of cetearyl alcohol polyether-20, 0.7 parts of disodium edetate) were added to 45 parts of deionized water, stirred at 75°C for 1.5 hours, and then 11.5 parts of oil phase (4.5 parts of olive oil, 2.5 parts of dimethicone, 1.5 parts of cetyl alcohol, 1.4 parts of stearyl alcohol, 1.6 parts of polyglyceryl-10 stearate) were slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material A;
[0066] S2: After the raw material A is cooled to 40°C, 0.6 parts of additives (0.5 parts of flavor, 0.05 parts of phenoxyethanol, and 0.05 parts of methylparaben) are slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material B;
[0067] S3: After the raw material B is cooled to 35°C, 8 parts of plant extracts (2.5 parts of rice complex, 2.5 parts of grapefruit extract, 1.5 parts of dipotassium glycyrrhizinate, and 1.5 parts of raspberry ketone glucoside) are slowly added, stirred for 20 to 30 minutes, and deionized water is added to make the total number of raw materials reach 120 parts. After homogenization, a whitening and moisturizing skin cream is obtained.
[0068] Comparative Example 3: Based on Example 1, grapefruit extract was not added, and the other processes remained unchanged.
[0069] Step 1: Preparation of rice complex: (1) Add 2.5 parts of anhydrous N-acetyl-D-mannosamine, 7.5 parts of acetic anhydride, and 0.5 parts of anhydrous sodium acetate into a flask, stir and reflux at 140°C for 2.5 hours, cool to 1°C to precipitate crystals, filter the crystals, purify, wash, and vacuum dry at 50°C for 3.5 hours to obtain acetylated mannosamine; (2) Grind 10 parts of rice through a 1000 mesh sieve, add to 85 parts of deionized water, disperse evenly with ultrasound, adjust the pH to 10, stir at 50°C for 1.5 hours, cool to 45°C, and then Then, 0.3 parts of alkaline protease was added, stirred evenly, kept warm for 3.5 hours, heated to 85°C and stirred for 15 minutes, lowered to room temperature, adjusted to pH 6, centrifuged at 5000 r / min for 30 minutes, took the supernatant, concentrated under reduced pressure, and freeze-dried to obtain rice polypeptide; (3) 9 parts of rice polypeptide, 4 parts of acetylated mannosamine and 3.5 parts of activator were added to 75 parts of deionized water, stirred evenly at 40°C, then 4.5 parts of 6-amino-β-cyclodextrin were added, stirred at 45°C for 3.5 hours, filtered, washed, and dried to obtain a rice complex;
[0070] Step 2: Preparation of whitening and moisturizing skin cream:
[0071] S1: 13 parts of aqueous phase (1 part of xanthan gum, 6 parts of glycerin, 2.5 parts of 1,3-butylene glycol, 1.3 parts of glyceryl stearate, 1.5 parts of cetearyl alcohol polyether-20, 0.7 parts of disodium edetate) were added to 45 parts of deionized water, stirred at 75°C for 1.5 hours, and then 11.5 parts of oil phase (4.5 parts of olive oil, 2.5 parts of dimethicone, 1.5 parts of cetyl alcohol, 1.4 parts of stearyl alcohol, 1.6 parts of polyglyceryl-10 stearate) were slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material A;
[0072] S2: After the raw material A is cooled to 40°C, 0.6 parts of additives (0.5 parts of flavor, 0.05 parts of phenoxyethanol, and 0.05 parts of methylparaben) are slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material B;
[0073] S3: After the raw material B is cooled to 35°C, 5.5 parts of plant extract (2.5 parts of rice complex, 1.5 parts of dipotassium glycyrrhizinate, 1.5 parts of raspberry ketone glucoside) are slowly added, stirred for 20 to 30 minutes, and deionized water is added to make the total number of raw materials reach 120 parts. After homogenization, a whitening and moisturizing skin cream is obtained.
[0074] Comparative Example 4: Based on Example 1, raspberry ketone glucoside was not added, and the other processes remained unchanged.
[0075] Step 1: Preparation of rice complex: (1) Add 2.5 parts of anhydrous N-acetyl-D-mannosamine, 7.5 parts of acetic anhydride, and 0.5 parts of anhydrous sodium acetate into a flask, stir and reflux at 140°C for 2.5 hours, cool to 1°C to precipitate crystals, filter the crystals, purify, wash, and vacuum dry at 50°C for 3.5 hours to obtain acetylated mannosamine; (2) Grind 10 parts of rice through a 1000 mesh sieve, add to 85 parts of deionized water, disperse evenly with ultrasound, adjust the pH to 10, stir at 50°C for 1.5 hours, cool to 45°C, and then Then, 0.3 parts of alkaline protease was added, stirred evenly, kept warm for 3.5 hours, heated to 85°C and stirred for 15 minutes, lowered to room temperature, adjusted to pH 6, centrifuged at 5000 r / min for 30 minutes, took the supernatant, concentrated under reduced pressure, and freeze-dried to obtain rice polypeptide; (3) 9 parts of rice polypeptide, 4 parts of acetylated mannosamine and 3.5 parts of activator were added to 75 parts of deionized water, stirred evenly at 40°C, then 4.5 parts of 6-amino-β-cyclodextrin were added, stirred at 45°C for 3.5 hours, filtered, washed, and dried to obtain a rice complex;
[0076] Step 2: Preparation of grapefruit extract: (1) Wash 25 parts of fresh grapefruit peel, put it in an oven at 75°C and dry it for 20 hours, take it out and cut it into small pieces, grind it, and pass it through a 200-grit sieve to obtain grapefruit peel powder; (2) Add 45 parts of anhydrous ethanol to 4 parts of grapefruit peel powder, ultrasonicate it at 200 W power at 45°C for 2.5 hours, centrifuge it at 7000 r / min for 15 minutes, take the supernatant, concentrate it under reduced pressure, and freeze-dry it to obtain grapefruit extract;
[0077] Step 3: Preparation of whitening and moisturizing skin cream:
[0078] S1: 13 parts of aqueous phase (1 part of xanthan gum, 6 parts of glycerin, 2.5 parts of 1,3-butylene glycol, 1.3 parts of glyceryl stearate, 1.5 parts of cetearyl alcohol polyether-20, 0.7 parts of disodium edetate) were added to 45 parts of deionized water, stirred at 75°C for 1.5 hours, and then 11.5 parts of oil phase (4.5 parts of olive oil, 2.5 parts of dimethicone, 1.5 parts of cetyl alcohol, 1.4 parts of stearyl alcohol, 1.6 parts of polyglyceryl-10 stearate) were slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material A;
[0079] S2: After the raw material A is cooled to 40°C, 0.6 parts of additives (0.5 parts of flavor, 0.05 parts of phenoxyethanol, and 0.05 parts of methylparaben) are slowly added, stirred for 20 to 30 minutes, and homogenized to obtain raw material B;
[0080] S3: After the raw material B is cooled to 35°C, 6.5 parts of plant extract (2.5 parts of rice complex, 2.5 parts of grapefruit extract, 1.5 parts of dipotassium glycyrrhizinate) are slowly added, stirred for 20 to 30 minutes, deionized water is added to make the total number of raw materials reach 120 parts, and homogenization is performed to obtain a whitening and hydrating skin cream.
[0081] Performance test: (1) Determination of moisturizing property: volunteers were selected to uniformly wash the designated marked area on the inside of their arms with deionized water and then wiped dry. After 30 minutes, the initial value of skin moisture content was tested using a Corneometer CM825 moisture test probe. After applying each skin cream sample, the skin moisture content was tested again 2 hours later. The test results were expressed as a percentage of the initial value. The test results are shown in Table 1. (2) Determination of melanin removal effect: volunteers were selected to expose their arms for 30 minutes and then tested using a Mexameter MX18 measures the initial value of skin melanin. After applying each skin care cream sample, the skin melanin content is tested again one week later, and the melanin content reduction rate is used as the test results. Table 1 shows (3) Usage experience measurement: Volunteers are selected to evaluate the skin care cream samples according to A, B, C, and D (A: the product has a light texture and is easy to apply. After use, the skin feels refreshed, non-greasy, and has no irritation or tightness; B: the product has a moderate texture and can be quickly absorbed by the skin after application, but may feel slightly greasy or take some time to reach the optimal comfort; C: the product absorbs slowly. After use, the skin may feel a little greasy or dry, and the comfort is average; D: the product has a heavy texture and is difficult to apply and absorb. After use, the skin is greasy or tight). The experimental data are shown in Table 1.
[0082] Table 1
[0083]
[0084] Conclusion: According to Table 1, the rice polypeptide in Comparative Example 1 is not modified, the moisturizing effect is poor, the melanin removal effect is general, and the skin absorption speed is slow; the rice complex in Comparative Example 2 is not encapsulated with cyclodextrin, the stability is reduced, the moisturizing and whitening effect is worse, and the moisturizing effect is reduced compared with Example 1; without adding grapefruit extract, the rice polypeptide cannot be promoted to penetrate into the deep layer of the skin, and the whitening and moisturizing effect is reduced; Comparative Example 4 does not add raspberry ketone glucoside, and the whitening effect and use experience are reduced.
[0085] In summary, the present invention successfully prepares a skin care cream with good moisturizing and whitening effects by introducing amino-β-cyclodextrin-encapsulated modified rice complex, grapefruit extract and raspberry ketone glucoside.
[0086] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.
Claims
1. A moisturizing and whitening skin cream, characterized in that: The invention comprises the following raw materials, calculated in 120 parts by mass: 9 to 14 parts of oil phase, 10.5 to 16.5 parts of water phase, 0.6 to 1.2 parts of additives, 6 to 10 parts of plant extracts, and the rest being deionized water; the plant extracts are rice complex and grapefruit extract.
2. A moisturizing and whitening skin cream according to claim 1, characterized in that: The oil phase includes the following substances, calculated by mass: 4 to 5 parts of olive oil, 2 to 3 parts of dimethicone, 1 to 2 parts of cetyl alcohol, 1 to 2 parts of stearyl alcohol, and 1 to 2 parts of polyglyceryl-10 stearate.
3. A moisturizing and whitening skin cream according to claim 1, characterized in that: The aqueous phase includes the following substances, calculated by mass: 1 to 1.5 parts of xanthan gum, 5 to 7 parts of glycerin, 2 to 3 parts of 1,3-butylene glycol, 1 to 2 parts of glyceryl stearate, 1 to 2 parts of cetearyl alcohol polyether-20, and 0.5 to 1 part of disodium ethylenediaminetetraacetate.
4. A moisturizing and whitening skin cream according to claim 1, characterized in that: The additives include the following substances, calculated by weight: 0.5 to 1 part of essence, 0.05 to 0.1 part of phenoxyethanol, and 0.05 to 0.1 part of methylparaben.
5. The moisturizing and whitening skin cream according to claim 1, characterized in that: The plant extract comprises the following substances, calculated by weight: 2 to 3 parts of rice complex, 2 to 3 parts of grapefruit extract, 1 to 2 parts of dipotassium glycyrrhizinate, and 1 to 2 parts of raspberry ketone glucoside.
6. A moisturizing and whitening skin cream according to claim 5, characterized in that: The preparation method of the rice composite comprises the following steps: (1) Add anhydrous N-acetyl-D-mannosamine, acetic anhydride, and anhydrous sodium acetate into a flask, stir and reflux at 140-145° C. for 2-3 hours, cool to 0-5° C. to precipitate crystals, filter, purify, wash, and vacuum dry at 50-55° C. for 3-4 hours to obtain acetylated mannosamine; (2) grinding the rice through a 800-1000 mesh sieve, adding it to 80-90 parts of deionized water, uniformly dispersing it by ultrasonication, adjusting the pH to 9-11, stirring it at 50-55° C. for 1.5-2 hours, cooling it to 45-50° C., then adding alkaline protease, stirring it uniformly, keeping it warm for 3-4 hours, heating it to 80-90° C. and stirring it for 15-20 minutes, cooling it to room temperature, adjusting the pH to 6-7, centrifuging it at 4000-5000 r / min for 20-30 minutes, taking the supernatant, concentrating it under reduced pressure, and freeze-drying it to obtain rice polypeptide; (3) Add rice polypeptide, acetylated mannosamine and activator into deionized water, stir evenly at 40-50° C., then add 6-amino-β-cyclodextrin, stir at 45-50° C. for 3-4 hours, filter, wash and dry to obtain a rice complex.
7. A moisturizing and whitening skin cream according to claim 6, characterized in that: The acetylated mannosamine comprises the following raw materials in parts by weight: 2-3 parts of anhydrous N-acetyl-D-mannosamine, 7-8 parts of acetic anhydride, and 0.4-0.6 parts of anhydrous sodium acetate; the rice polypeptide comprises the following raw materials in parts by weight: 9-11 parts of rice and 0.2-0.4 parts of alkaline protease; the rice complex comprises the following raw materials in parts by weight: 8-10 parts of rice polypeptide, 3-5 parts of acetylated mannosamine, 3-4 parts of activator, and 4-5 parts of 6-amino-β-cyclodextrin.
8. The moisturizing and whitening skin cream according to claim 5, characterized in that: The preparation method of the grapefruit extract comprises the following steps: (1) Clean fresh grapefruit peel, put it in an oven at 70-80° C. and dry it for 20-22 hours, take it out, cut it into small pieces, grind it, and pass it through a 200-400 mesh sieve to obtain grapefruit peel powder; (2) Add 40-50 parts of anhydrous ethanol to grapefruit peel powder, ultrasonicate at 200-300 W at 40-50° C. for 2-3 h, centrifuge at 7000-8000 r / min for 15-20 min, collect the supernatant, concentrate under reduced pressure, and freeze-dry to obtain a grapefruit extract.
9. A moisturizing and whitening skin cream according to claim 8, characterized in that: The grapefruit peel powder comprises the following raw materials in parts by mass: 20 to 30 parts of fresh grapefruit peel; the grapefruit extract comprises the following raw materials in parts by mass: 3 to 5 parts of grapefruit peel powder.
10. The method for preparing a moisturizing and whitening skin cream according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1: Add the aqueous phase to deionized water, stir at 70-80°C for 1-2h, then slowly add the oil phase, stir for 20-30min, and homogenize to obtain raw material A; S2: After the raw material A is cooled to 40-45°C, the additive is slowly added, stirred for 20-30 minutes, and homogenized to obtain the raw material B; S3: After the raw material B is cooled to 35-40° C., the plant extract is slowly added, stirred for 20-30 minutes, supplemented with deionized water, and homogenized to obtain a whitening and hydrating skin cream.