Freeze-dried material moving and taking mechanism, double-cavity pre-filling injector production line, production method, control device and storage medium

Abstract

The invention provides a freeze-drying material moving and taking mechanism, a double-cavity pre-filling injector production line, a production method, a control device and a storage medium. The freeze-drying material moving and taking mechanism is provided with a first feeding conveying assembly used for feeding medicinal containers, a second feeding conveying assembly used for feeding freeze-drying materials and a taking and placing assembly used for moving and taking the freeze-drying materials supplied by the second feeding conveying assembly into the medicinal containers supplied by the first feeding conveying assembly. The second feeding conveying assembly comprises a first screw and a second screw which are coaxially arranged, and the feeding state of the freeze-drying materials can be adjusted through different rotation frequencies of the first screw and the second screw. Therefore, the feeding of the freeze-drying material can be matched with the feeding of the medicinal container, so that the pre-filling and production effects of the double-cavity pre-filling injector are improved.

Description

Technical Field

[0001] The present application relates to the technical field of medical equipment, and in particular to a freeze-dried material removal mechanism, a double-chamber prefilled syringe production line, a production method, a control device and a storage medium. Background Art

[0002] A syringe is a common medical device, which is mainly used to extract or inject liquid through a needle.

[0003] There is a special type of syringe, a double-chamber prefilled syringe, which is widely used in situations where multiple drugs or liquids need to be mixed and used. This type of syringe is provided with two independent chambers, each of which stores different liquids or drugs, and a connecting channel for connecting the two chambers is also provided on the syringe barrel. When in use, the user changes the position of the rubber plug in the syringe by pressing the push rod of the syringe. When the rubber plug moves to the position of the connecting channel, the two chambers are connected through the connecting channel, and the components in the two chambers can be mixed with each other.

[0004] However, current production equipment cannot well implement the pre-filling and production of double-chamber pre-filled syringes. Summary of the invention

[0005] The present application provides a freeze-dried material removal mechanism, a double-chamber prefilled syringe production line, a production method, a control device and a storage medium to improve the prefilling and production of the double-chamber prefilled syringe.

[0006] The first aspect of the present application provides a freeze-dried material removal mechanism, which comprises:

[0007] A first loading and conveying assembly is used to load the medicinal container;

[0008] A second loading and conveying assembly is used to load the freeze-dried material, and the second loading and conveying assembly includes a first driving mechanism, a second driving mechanism, and a first screw and a second screw arranged coaxially, the first driving mechanism is transmission-connected to the first screw, the second driving mechanism is transmission-connected to the second screw, and the first screw and the second screw are adjacently arranged along the conveying direction of the second loading and conveying assembly; and a picking and placing assembly is used to transfer the freeze-dried material supplied by the second loading and conveying assembly to the medicinal container supplied by the first loading and conveying assembly.

[0009] In some embodiments, the second screw is provided with a first loading position and a second loading position, the first loading position is located downstream of the second loading position, and the second screw can adjust the loading state by switching the rotation frequency.

[0010] In some embodiments, the second screw can switch between four loading states, wherein, in a first loading state, both the first loading position and the second loading position have freeze-dried material; in a second loading state, the first loading position does not have freeze-dried material, and the second loading position has freeze-dried material; in a third loading state, the first loading position has freeze-dried material, and the second loading position does not have freeze-dried material; in a fourth loading state, both the first loading position and the second loading position have no freeze-dried material.

[0011] In some embodiments, the freeze-dried material removal mechanism further includes a detection mechanism, which is used to detect the loaded medicinal container and obtain the detection result; the second loading and conveying component adjusts the loading state of the second screw according to the detection result.

[0012] In some embodiments, the pick-and-place assembly includes a driving mechanism and at least one group of pick-and-place units, wherein the driving mechanism is used to drive the pick-and-place units to move between the first loading and conveying assembly and the second loading and conveying assembly to load the freeze-dried material into the medicinal container.

[0013] In some embodiments, the driving member can drive the pick-and-place unit to switch between the first station and the third station; at the first station, at least one group of the pick-and-place units corresponds to the first loading position and the second loading position of the second screw to obtain the freeze-dried material; at the third station, at least one group of the pick-and-place units corresponds to the position of the first loading and conveying assembly to place the freeze-dried material in a medicinal container.

[0014] In some embodiments, the driving member can also drive the pick-and-place unit to a second station, where a second detection mechanism is provided, and the second detection mechanism is used to detect the freeze-dried material.

[0015] In some embodiments, the driving member can also drive the pick-and-place unit to a fourth station, where the fourth station is a cleaning station.

[0016] In some embodiments, each group of pick-and-place units includes two pick-and-place members, and the arrangement positions of the two pick-and-place members correspond to the arrangement positions of the first loading position and the second loading position.

[0017] In some embodiments, the driving member includes a rotating driving member, which is transmission-connected to the pick-and-place unit to drive the pick-and-place unit to rotate and switch between a first station, a second station, a third station, and a fourth station; the first station, the second station, the third station, and the fourth station are arranged in sequence and evenly along the circumferential direction.

[0018] In some embodiments, the pick-and-place unit includes at least one pick-and-place member, which is a vacuum adsorption member. A collection container is provided at the fourth station to collect ejected matter when the pick-and-place member ejects air outward.

[0019] In some embodiments, the pick-and-place assembly is further provided with a central axis, a vacuum source and a bracket, the central axis is connected to the bracket via the air slip ring, the vacuum source gas is connected to the air slip ring, and the air slip ring gas is connected to each of the vacuum adsorption components to provide positive pressure or negative pressure for each of the vacuum adsorption components.

[0020] In some embodiments, the pick-and-place assembly includes four groups of pick-and-place units, and the four groups of pick-and-place units are evenly arranged along the circumference.

[0021] In some embodiments, the driving member further includes a lifting driving member, and the lifting driving member is connected to the pick-and-place unit and is used to drive the pick-and-place unit to rise and fall.

[0022] In some embodiments, the freeze-dried material removal mechanism also includes a connecting member, the rotating drive member is arranged on the connecting member, the pick-and-place assembly has a central axis, the pick-and-place unit is connected to the central axis, the central axis is rotatably connected to the connecting member and is transmission-connected to the rotating drive member, and the lifting drive member is connected to the connecting member to drive the connecting member, the rotating drive member and the pick-and-place unit to rise and fall.

[0023] In some embodiments, the freeze-dried material removal mechanism also includes a guide column, a guide sleeve and a fixed frame, one of the guide column and the guide sleeve is connected to the fixed frame, and the other is connected to the connecting piece, and the guide column is fitted in the guide sleeve, and the guide column extends along the direction of the lifting and lowering of the connecting piece.

[0024] A second aspect of the present application provides a double-chamber prefilled syringe production line, which includes a filling unit, the filling unit comprising:

[0025] A first sealing mechanism, used to set a first sealing body in the medicinal container;

[0026] A filling mechanism, disposed downstream of the first sealing mechanism, and used for filling liquid into the medicinal container;

[0027] a second sealing mechanism, arranged downstream of the filling mechanism, the second sealing mechanism being used to arrange a second sealing body in the medicinal container, a liquid chamber for containing the liquid being formed between the first sealing body and the second sealing body;

[0028] The freeze-dried material removal mechanism provided in any of the above embodiments, wherein the freeze-dried material removal mechanism is arranged downstream of the second sealing mechanism, and is used to add the freeze-dried material into the medicinal container;

[0029] The third sealing mechanism is arranged downstream of the freeze-dried material removing mechanism, and is used to arrange a third sealing body in the medicinal container for sealing the freeze-dried material.

[0030] In some embodiments, a first flipping mechanism is further provided downstream of the second sealing mechanism and upstream of the freeze-dried material removal mechanism, and the first flipping mechanism is used to flip the medicinal container; a chamber for accommodating the freeze-dried material is formed between the first sealing body and the third sealing body.

[0031] In some embodiments, the double-chamber prefilled syringe production line also includes a third detection mechanism, which is located downstream of the freeze-dried material removal mechanism and upstream of the third sealing mechanism, and is used to detect the connectivity between the liquid chamber for containing liquid in the medicinal container and the chamber for containing freeze-dried material.

[0032] In some embodiments, the dual-chamber prefilled syringe production line further comprises a laminar flow hood, wherein the first sealing mechanism, the filling mechanism, the second sealing mechanism and the freeze-dried material transfer mechanism are arranged in the laminar flow hood and are in a Class A laminar flow environment.

[0033] In some embodiments, the dual-chamber prefilled syringe production line further comprises:

[0034] a medicinal container supply unit, disposed upstream of the filling unit, for supplying medicinal containers to the filling unit;

[0035] A freeze-dried material supply unit is arranged upstream of the filling unit to supply freeze-dried material to the filling unit; and a discharge unit is arranged downstream of the filling unit to discharge the material after assembling the medicinal containers pre-filled with liquid components and freeze-dried materials into syringes.

[0036] The third aspect of the present application provides a method for producing a double-chamber prefilled syringe, comprising the following steps:

[0037] Loading the medicinal container by means of a first loading and conveying assembly;

[0038] Loading the freeze-dried material through the second loading and conveying assembly;

[0039] The freeze-dried material supplied by the second loading and conveying assembly is transferred to the medicinal container supplied by the first loading and conveying assembly by means of the pick-and-place assembly;

[0040] Among them, the second loading and conveying assembly has four loading states. In the first loading state, the first loading position and the second loading position of the second loading and conveying assembly both have freeze-dried materials; in the second loading state, the first loading position does not have freeze-dried materials, and the second loading position has freeze-dried materials; in the third loading state, the first loading position has freeze-dried materials, and the second loading position does not have freeze-dried materials; in the fourth loading state, both the first loading position and the second loading position have no freeze-dried materials.

[0041] In some embodiments, the method further includes the following steps: detecting the loaded medicinal container by a detection mechanism and obtaining a detection result; and switching the loading state of the second loading and conveying component according to the detection result.

[0042] In some embodiments, the step of transferring the freeze-dried material supplied by the second loading and conveying assembly to the medicinal container supplied by the first loading and conveying assembly by the pick-and-place assembly specifically includes:

[0043] At the first station, the freeze-dried material supplied by the second loading and conveying assembly is obtained by the pick-and-place assembly;

[0044] The pick-and-place assembly is rotated to the third station, and the freeze-dried material is placed in a medicinal container.

[0045] In some embodiments, before the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material in a medicinal container, the pick-and-place assembly is rotated to the second station and the freeze-dried material is detected by a second detection mechanism.

[0046] In some embodiments, the pick-and-place assembly removes the freeze-dried material by vacuum adsorption. After the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material in a medicinal container, the pick-and-place assembly is rotated to the fourth station, and air is sprayed outward at the fourth station to clean the air path of the pick-and-place assembly.

[0047] In some embodiments, before the step of loading the medicinal container with the first loading and conveying assembly, the medicinal container is filled with liquid to form a liquid chamber for containing the liquid.

[0048] In some embodiments, before the step of loading the medicinal container by the first loading and conveying assembly, the medicinal container is supplied by the medicinal container supply unit; before the step of loading the freeze-dried material by the second loading and conveying assembly, the freeze-dried material is supplied by the freeze-dried material supply unit; after the step of transferring the freeze-dried material supplied by the second loading and conveying assembly to the medicinal container supplied by the first loading and conveying assembly by the picking and placing assembly, the medicinal container pre-filled with liquid components and freeze-dried materials is assembled into a syringe by the discharging unit and then discharged.

[0049] A fourth aspect of the present application provides a control device for a double-chamber prefilled syringe production line, comprising:

[0050] The freeze-dried material removal mechanism provided by any of the aforementioned embodiments;

[0051] A testing mechanism, used to test the loaded medicinal containers and obtain the test results;

[0052] The controller is connected to the freeze-dried material removal mechanism and the detection mechanism by signal, and adjusts the feeding state of the second screw of the freeze-dried material removal mechanism according to the detection result.

[0053] The fifth aspect of the present application provides a non-volatile computer-readable storage medium, on which a computer program is stored, and the computer program is executed by a processor to implement the steps in the method for producing a double-chamber prefilled syringe provided in any of the aforementioned embodiments.

[0054] The present application has the following beneficial effects: the present application provides a freeze-dried material transfer mechanism, a dual-chamber prefilled syringe production line, a production method, a control device and a storage medium, wherein the freeze-dried material transfer mechanism is provided with a first loading and conveying assembly for loading a medicinal container, a second loading and conveying assembly for loading a freeze-dried material and a pick-and-place assembly for transferring the freeze-dried material supplied by the second loading and conveying assembly to a medicinal container supplied by the first loading and conveying assembly, wherein the second loading and conveying assembly includes a first screw and a second screw arranged coaxially, and the loading state of the freeze-dried material can be adjusted by different rotation frequencies of the first screw and the second screw. Thus, the loading of the freeze-dried material can be matched with the loading of the medicinal container, thereby improving the prefilling and production effects of the dual-chamber prefilled syringe. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0056] Figure 1 A top view of a freeze-dried material removal mechanism is shown as an example.

[0057] Figure 2 A schematic structural diagram of a freeze-dried material removal mechanism is shown as an example.

[0058] Figure 3 A front view of a freeze-dried material removal mechanism is exemplarily shown.

[0059] Figure 4 A schematic diagram exemplarily shows the second loading and conveying assembly in the first loading state.

[0060] Figure 5 A schematic diagram exemplarily shows the second loading conveying assembly in the second loading state.

[0061] Figure 6 A schematic diagram exemplarily shows the second feeding conveying assembly in the third feeding state.

[0062] Figure 7 A schematic diagram exemplarily shows the second feeding conveying assembly in the fourth feeding state.

[0063] Figure 8 The structural schematic diagram of the other side of a freeze-dried material removal mechanism is exemplarily shown.

[0064] Fig. 9 A side view of a freeze-dried material removal mechanism is shown as an example.

[0065] Fig.10 The schematic diagram of the structure of a double-chamber prefilled syringe production line is shown as an example.

[0066] Fig.11 A schematic flow chart showing a method for producing a double-chamber prefilled syringe is shown as an example.

[0067] Fig.12 A schematic diagram showing, by way of example, a control device for a production line for double-chamber prefilled syringes.

[0068] Description of the elements in the figure: 10-freeze-dried material removal mechanism, 100-first loading and conveying assembly 100, 200-second loading and conveying assembly, 210-first driving mechanism, 220-second driving mechanism, 230-first screw, 240-second screw, 241-first loading position, 242-second loading position, 300-pick-and-place assembly, 310-pick-and-place member, 320-driving member, 321-rotating driving member, 322-lifting driving member, 330-fixed frame, 340-connecting member, 350-central axis, 360-air slip ring, 370-bracket, 400-freeze-drying mold collection tray, 500-second detection mechanism, 600-detection mechanism, A-first group of pick-and-place units, B-second group of pick-and-place units, C-third group of pick-and-place units, D-fourth group of pick-and-place units.

[0069] 20 - medicinal container supply unit, 21 - unpacking mechanism, 22 - box sealing paper heating mechanism, 23 - paper taking mechanism, 24 - nest plate taking mechanism, 25 - medicinal container taking mechanism.

[0070] 30-freeze-dried material supply unit, 31-freeze-drying mold feeding mechanism, 32-front weighing mechanism, 33-freeze-dried material filling mechanism, 34-rear weighing mechanism, 35-freeze-drying feeding mechanism, 36-freeze-drying mechanism, 37-capping mechanism.

[0071] 40 - filling unit, 41 - first sealing mechanism, 42 - filling mechanism, 43 - second sealing mechanism, 44 - first detection mechanism, 45 - first turning mechanism, 46 - freeze-dried material pre-loading machine, 47 - third sealing mechanism.

[0072] 50-discharging unit, 51-adapter mounting mechanism, 52-top cap mounting mechanism, 53-medicinal container turning mechanism, 54-back push mounting mechanism, 55-discharging mechanism.

[0073] 60-Medicinal containers.

[0074] 70 - a control device for a double-chamber prefilled syringe production line, 71 - a processor, 72 - a memory. DETAILED DESCRIPTION

[0075] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application. In addition, it should be understood that the specific implementation methods described herein are only used to illustrate and explain the present application and are not used to limit the present application. In the present application, unless otherwise stated, the directional words used, such as "up", "down", "left", and "right", generally refer to the up, down, left, and right of the device in actual use or working state, specifically the drawing direction in the accompanying drawings.

[0076] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features.

[0077] The present application provides a freeze-dried material removal mechanism, a dual-chamber prefilled syringe production line, a production method, a control device and a storage medium, which are described in detail below. It should be noted that the description order of the following embodiments is not intended to limit the preferred order of the embodiments of the present application. In the following embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, please refer to the relevant description of other embodiments.

[0078] See also Figure 1 An embodiment of the present application provides a freeze-dried material removal mechanism 10, which includes a first loading and conveying component 100, a second loading and conveying component 200 and a pick-and-place component 300.

[0079] The first loading conveyor assembly 100 is used to load the medicinal container 60. For example, the medicinal container 60 flipped by the first flip mechanism 45 is conveyed to one side of the pick-and-place assembly 300 by the first loading conveyor assembly 100. The relevant content of the first flip mechanism 45 will be described later. Of course, it can be understood that, in the case where the first flip mechanism 45 is not provided, the first loading conveyor assembly 100 can simply convey the medicinal container 60 from the upstream to one side of the pick-and-place assembly 300. The first loading conveyor assembly 100 can include a conveyor line, etc.

[0080] The second loading and conveying assembly 200 is used to load freeze-dried materials, which may include a conveying line, etc. For example, the freeze-dried materials from the freeze-dried material supply unit 30 are conveyed to one side of the pick-and-place assembly 300, and the relevant contents of the freeze-dried material supply unit 30 will be described later.

[0081] Here, illustratively, the conveying direction of the first loading conveyor assembly 100 and the conveying direction of the second loading conveyor assembly 200 are arranged in parallel. Figure 1 In the illustrated state, the conveying directions of both are from left to right. The first loading conveyor assembly 100 and the second loading conveyor assembly 200 are respectively located on both sides of the pick-and-place assembly 300 to save space and facilitate the pick-and-place assembly 300 to load the freeze-dried material into the medicinal container 60. Of course, the example of this embodiment does not constitute an undue limitation to it. In other embodiments, the first loading conveyor assembly 100 and the second loading conveyor assembly 200 can also be located at other positions, such as on the same side of the pick-and-place assembly 300, or on the adjacent side of the pick-and-place assembly 300, etc.

[0082] Here, see Figure 2 The second feeding conveying assembly 200 includes a first screw 230 and a second screw 240 which are coaxially arranged. Figure 3 The second feeding conveying assembly 200 also includes a first driving mechanism 210 and a second driving mechanism 220. The first driving mechanism 210 is transmission-connected to the first screw 230, and the second driving mechanism 220 is transmission-connected to the second screw 240. The first screw 230 and the second screw 240 are adjacently arranged along the conveying direction of the second feeding conveying assembly 200 to realize the function of spiral conveying. The first driving mechanism 210 and the second driving mechanism 220 can be arranged on a fixed fixing frame 330. Here, illustratively, a transfer conveying line can also be arranged on the upstream side of the first screw 230 to feed the first screw 230.

[0083] Specifically, taking the first screw 230 as an example, a receiving position for accommodating the freeze-dried material is formed between two adjacent blades of the first screw 230. Under the drive of the first driving mechanism 210, the first screw 230 rotates a set angle and causes the freeze-dried material to move forward a stroke, thereby realizing the spiral conveying of the freeze-dried material. Similarly, a receiving position for accommodating the freeze-dried material is also formed between two adjacent blades of the second screw 240. Under the drive of the second driving mechanism 220, the second screw 240 rotates a set angle and causes the freeze-dried material to move forward a stroke, thereby realizing the spiral conveying of the freeze-dried material. The essence is to split a spiral conveying rod into a first screw 230 and a second screw 240 that are arranged in succession.

[0084] Thus, the freeze-dried material can be continuously transported forward when the first screw 230 and the second screw 240 rotate synchronously. In some cases, if the number of rotations of the first screw 230 and the second screw 240 is adjusted so that the number of rotations of the second screw 240 is greater than the number of rotations of the first screw 230, differential transportation can be achieved to cooperate with the subsequent pick-and-place assembly 300 to move the freeze-dried material.

[0085] For example, the rotation frequency of the second screw 240 is set to twice that of the first screw 230. At this time, the first screw 230 rotates one circle to move a portion of freeze-dried material forward one stroke and is transported to the second screw 240. As for the second screw 240, it rotates two circles to move the previous portion of freeze-dried material at the original position of the freeze-dried material forward two strokes. As a result, an empty accommodating position is formed between the previous portion of freeze-dried material and the current portion of freeze-dried material.

[0086] In this embodiment, the second screw 240 of the second feeding conveying assembly 200 includes two feeding positions, which may be any two accommodating positions for accommodating freeze-dried materials on the second screw 240. For example, they may be two accommodating positions for accommodating freeze-dried materials formed between three blades on the second screw 240 at one end farthest from the second screw 240.

[0087] Please see Figure 4 In this embodiment, the two loading positions are defined as a first loading position 241 and a second loading position 242. The first loading position 241 is located downstream of the second loading position 242, that is, the first loading position 241 is located on the side of the second loading position 242 away from the first screw 230. Therefore, by controlling the number of rotations of the second screw 240 and the first screw 230, the second screw 240 can have four loading states, namely, the first loading state, the second loading state, the third loading state and the fourth loading state.

[0088] In the first loading state, both the first loading position 241 and the second loading position 242 have freeze-dried materials. For example, when loading two adjacent freeze-dried materials, this can be achieved by making the second screw 240 and the first screw 230 rotate the same number of times.

[0089] See also Figure 5 In the second loading state, the first loading position 241 does not have freeze-dried material, and the second loading position 242 has freeze-dried material. For example, before loading a freeze-dried material onto the second screw 240, the second screw 240 is rotated one more circle than the first screw 230 to achieve this.

[0090] See also Figure 6 In the third loading state, the first loading position 241 has freeze-dried material, and the second loading position 242 does not have freeze-dried material. For example, after a freeze-dried material is loaded onto the second screw 240, the second screw 240 is rotated one more circle than the first screw 230 to achieve this.

[0091] See also Figure 7In the fourth loading state, there is no freeze-dried material at the first loading position 241 and the second loading position 242. For example, the second screw 240 can be rotated one circle while the first screw 230 does not rotate.

[0092] It is understandable that this embodiment is described by taking the second screw 240 including two loading positions as an example, but the second screw 240 itself can have more accommodating positions for accommodating freeze-dried materials. In addition, in other embodiments, the second screw 240 can also have other numbers of loading positions, such as three, four, five, etc. And, in other embodiments, the second screw 240 may not have a fourth loading state, etc. The examples in this embodiment do not constitute an undue limitation to it.

[0093] In this embodiment, please refer to Figure 1 The pick-and-place assembly 300 includes at least one group of pick-and-place units, and each group of pick-and-place units includes at least one pick-and-place member 310. Exemplarily, the pick-and-place assembly 300 has four groups of pick-and-place units, namely, a first group of pick-and-place units A, a second group of pick-and-place units B, a third group of pick-and-place units C, and a fourth group of pick-and-place units D. The four groups of pick-and-place units are evenly arranged along the circumference, that is, the angle between two adjacent groups of pick-and-place units is approximately a right angle.

[0094] Here, the position and number of the pick-and-place members 310 in each group of pick-and-place units correspond to the loading positions of the aforementioned second screw 240. For example, the following is also explained with the case where the second screw 240 has two loading positions, and the number of the pick-and-place members 310 in each group of pick-and-place units is also correspondingly two, and corresponds to the positions of the two loading positions of the second screw 240. That is, the two pick-and-place members 310 are arranged in sequence along the setting direction of the loading positions, and can be used to simultaneously pick up and place the freeze-dried materials at the two loading positions. It can be understood that when the number of loading positions is three, four, five, etc., the number of the pick-and-place members 310 in each group of pick-and-place units is correspondingly three, four, five, etc.

[0095] See also Figure 8 , the pick-and-place assembly 300 further includes a rotary drive member 321, which is connected to the pick-and-place unit to drive the pick-and-place member 310 of the pick-and-place unit to rotate. The rotary drive member can be a motor, etc., for example, it can be connected to the pick-and-place assembly 300 through a reduction gear box, a bevel gear transmission mechanism, etc. Thus, the pick-and-place unit can be driven to rotate through the rotary drive member 321. It can be understood that in Figure 2 and Figure 8 In order to facilitate observation of the relative positional relationship between the pick-and-place member 310 and the medicinal container 60, the first loading and conveying assembly 100 is not shown.

[0096] Here, the pick-and-place assembly 300 has four stations, namely the first station, the second station, the third station and the fourth station. When the pick-and-place assembly 300 is driven to rotate by the rotary drive member 321, each group of pick-and-place units can be rotated and switched between the four stations. Exemplarily, the first station, the second station, the third station and the fourth station are arranged uniformly in sequence along the circumferential direction, that is, the angle between two adjacent stations is approximately 90 degrees. Of course, in other embodiments, according to actual needs, the arrangement positions of the four stations may also be different, and this embodiment does not constitute an undue limitation thereto.

[0097] Here, the movement process of each group of pick-and-place units is the same. In this embodiment, the movement process of a group of pick-and-place units is used as an example for illustrative description.

[0098] At the first station, a set of pick-and-place units' pick-and-place components 310 correspond to the loading position of the second screw 240, and the pick-and-place components 310 can remove the freeze-dried material at the loading position. For example, the pick-and-place components 310 are vacuum suction components that absorb the freeze-dried material at the loading position by vacuum suction. For example, Figure 1 The position of the first group of pick-and-place units A is the position of the first workstation.

[0099] At the second station, a second detection mechanism 500 is provided, and the second detection mechanism 500 is used to detect whether the pick-up and placement member 310 has obtained the freeze-dried material. Here, the second detection mechanism 500 can be a visual detection mechanism such as a camera. Of course, in other embodiments, it can also be other infrared detection mechanisms, etc. This embodiment does not constitute an undue limitation to it. In addition, illustratively, the group of pick-up and placement units can be rotated approximately 90 degrees from the previous state to rotate from the first station to the second station. Again illustratively, Figure 1 The position of the second group of pick-and-place units B is the position of the second workstation.

[0100] At the third station, the group of pick-and-place units moves to a position corresponding to the first loading and conveying assembly 100 and corresponds to the position of the medicinal container 60 on the first loading and conveying assembly 100, for example, moves to the upper side of the first loading and conveying assembly 100, and the arrangement of the medicinal containers 60 on the first loading and conveying assembly 100, the arrangement of the loading positions of the second loading and conveying assembly 200, and the arrangement of the pick-and-place components 310 in each group of pick-and-place units correspond to each other. Thus, when rotating to the third station, the pick-and-place components 310 of the group of pick-and-place units can place the freeze-dried material into the corresponding medicinal container 60. In addition, illustratively, the group of pick-and-place units can be rotated approximately 90 degrees from the previous state to rotate from the second station to the third station. Again illustratively, Figure 1 The position of the third group of pick-and-place units C is the position of the third workstation.

[0101] At the fourth station, this position is a cleaning station. Exemplarily, Figure 1 The position of the fourth group of pick-and-place units D is the position of the fourth station. Here, since the particles of the freeze-dried material may fall off, the pick-and-place assembly 300 may be attached with some of the particles of the freeze-dried material, which will cause the pick-and-place assembly 300 to be contaminated, and it is possible that the particles of the freeze-dried material will be attached to the subsequent freeze-dried material during subsequent use, thereby affecting the quality of the subsequent freeze-dried material. In particular, when the pick-and-place component 310 is a vacuum adsorption component, the particles of the freeze-dried material may continue to block the air path of the vacuum adsorption.

[0102] For this reason, at the fourth station, the group of pick-and-place units will be cleaned. For example, when the pick-and-place member 310 is a vacuum adsorption member, the air path is cleaned by controlling the pick-and-place member 310 to spray outward. Exemplarily, a collection container can also be provided at the fourth station, and the pick-and-place member 310 of the group of pick-and-place units can be moved to a position corresponding to the collection container, and spray to spray the particles of the freeze-dried material and other ejecta into the collection container. Of course, in other embodiments, the cleaning station can also be provided with other structures and other methods for cleaning, such as a brush that can reciprocate to clean the pick-and-place member 310, a high-pressure nozzle and a drying device are provided to clean with a high-pressure liquid and then dry, etc. The examples in this embodiment do not constitute an undue limitation to it.

[0103] It is understandable that four groups of pick-and-place units and four workstations are provided here. In actual operation, a group of pick-and-place units is working at each workstation, thereby ensuring the continuity of the operation of the pick-and-place assembly 300 and improving work efficiency. However, in other embodiments, the number of pick-and-place units and workstations may not correspond, for example, only one group, two groups, or other number of groups of pick-and-place units are provided. In addition, the above-mentioned example is illustrated by taking four workstations as an example. In other embodiments, only the first workstation and the third workstation may be provided, or the fourth workstation may not be provided. The examples in this embodiment do not constitute an undue limitation to the present application.

[0104] It is understandable that this embodiment is described by taking the example of a rotary drive member 321, but in other embodiments, according to actual needs, the rotary drive member 321 can also be replaced by other linear displacement drive members, curved displacement drive members, and other drive members 320. It is only necessary for the drive member 320 to drive the pick-and-place member 310 of the pick-and-place unit to move between the first loading and conveying assembly 100 and the second loading and conveying assembly 200 to load the freeze-dried material to the medicinal container 60. The example in this embodiment does not constitute an undue limitation to it. In addition, the above embodiment is described by taking the example of the drive member 320 driving each group of the pick-and-place unit. In other embodiments, the drive member 320 can also drive each pick-and-place member 310. The example in this embodiment does not constitute an undue limitation to it.

[0105] Also, see Figure 8 The driving member 320 of the freeze-dried material removing mechanism 10 may further include a lifting driving member 322, and the lifting driving member 322 is connected to the pick-and-place unit to drive the pick-and-place member 310 of the pick-and-place unit to rise and fall.

[0106] Exemplarily, a connecting member 340 may be provided, and the pick-and-place assembly 300 is provided on the connecting member 340. The connecting member 340 may be an integral structure or a structure formed by connecting a plurality of connecting blocks. The lifting drive member 322 may be a motor or a telescopic cylinder. For example, when the lifting drive member 322 is a motor, it sequentially connects to a reduction gearbox and a lead screw and transmits power to the connecting member 340 to drive the connecting member 340 and the pick-and-place assembly 300 thereon to rise and fall roughly in the vertical direction; for another example, when the lifting drive member 322 is a telescopic cylinder, it is directly or indirectly connected to the connecting member 340 to drive the connecting member 340 and the pick-and-place assembly 300 thereon to rise and fall roughly in the vertical direction. Of course, in other embodiments, the lifting drive member 322 may also be other structures, and the lifting drive member 322 may also be directly or indirectly connected to the pick-and-place assembly 300 in other ways, as long as it can drive the pick-and-place assembly 300 to lift and lower. For example, the lifting drive member 322 may include a telescopic cylinder corresponding to each pick-and-place member 310 or each group of pick-and-place units, and the examples in this embodiment do not constitute an undue limitation to it.

[0107] Thus, the lifting drive 322 can drive the pick-and-place member 310 to rise and fall. For example, when the pick-and-place member 310 is located at the first station, the pick-and-place member 310 is driven and moved downward to obtain the freeze-dried material, and then moved upward to reset; for another example, when the pick-and-place member 310 is located at the third station, the pick-and-place member 310 is driven and moved downward to put down the freeze-dried material, and then moved upward to reset. Of course, when there is no need for lifting, the lifting drive 322 may not be provided, and the examples in this embodiment do not constitute an improper limitation to it.

[0108] In addition, at the second station or the fourth station, the pick-and-place member 310 can also be moved to the required corresponding position by lifting, such as the detection position of the second station and the cleaning position of the fourth station. Of course, in other embodiments, the detection position of the second station and the cleaning position of the fourth station can also be set at the position before the lowering, and the example in this embodiment does not constitute an improper limitation thereto.

[0109] Here, by way of example, see Figure 8 , the pick-and-place assembly 300 has a central axis 350, the pick-and-place unit is connected to the central axis 350, and the central axis 350 is rotatably connected to the connecting member 340 and is in transmission connection with the rotating driving member 321. The lifting driving member 322 is arranged on a fixed frame 330, and the lifting driving member 322 is directly or indirectly connected to the pick-and-place unit, for example, the lifting driving member 322 is connected to the connecting member 340. When the lifting driving member 322 drives the connecting member 340 to rise and fall, the rotating driving member 321 and the pick-and-place unit are also driven to rise and fall. Here, the aforementioned first driving mechanism 210 and the second driving mechanism 220 can also be arranged on the fixed frame 330. It can be understood that in other embodiments, the first driving mechanism 210, the second driving mechanism 220 and the lifting driving member 322 can also be arranged on different fixed frames 330 respectively, and this embodiment does not impose improper restrictions on them.

[0110] Of course, in other embodiments, the rotating driving member 321 may be connected to the connecting member 340 to drive the connecting member 340 to rotate as a whole, and the lifting driving member 322 may be arranged on the connecting member 340, and the picking and placing assembly 300 may be connected to the lifting driving member 322 in a transmission manner and may be connected to the connecting member 340 in a liftable manner, which may also achieve similar technical effects. The examples in this embodiment do not constitute an undue limitation thereto.

[0111] The coordinated arrangement of the rotary drive member 321 and the lifting drive member 322 achieves a compact structural design, which helps reduce the space occupied by the overall structure and improves work efficiency. In particular, the arrangement of the rotary drive member 321 and the four workstations evenly arranged along the circumference effectively improves its work efficiency.

[0112] In an embodiment in which a rotary drive member 321 is provided and the pick-and-place member 310 is a vacuum adsorbent, the pick-and-place assembly 300 has a central axis 350, and an air slip ring 360 is provided on the central axis 350 and connected to a bracket 370 through the air slip ring 360. The vacuum source is connected to the air slip ring 360 through a pipeline gas, and the air slip ring 360 is connected to each vacuum adsorbent through a pipeline gas to provide positive pressure or negative pressure for each vacuum adsorbent. The vacuum source can be a pump, etc. The air slip ring 360 can be provided to achieve air path connection in a rotating state. The air slip ring 360 is a structure for achieving air path sealing and connection, which is a prior art in the field of air path connection, and this embodiment will not be described in detail.

[0113] Here, vacuum adsorption can be used to effectively and conveniently place and move the freeze-dried material, so as to improve the pre-loading efficiency of the freeze-dried material. At the same time, the freeze-dried material will not be damaged, which helps to ensure the loading quality of the freeze-dried material.

[0114] In some embodiments, in order to make the connecting member 340 and the pick-and-place assembly 300 have better alignment when lifting, a guide column and a guide sleeve may also be provided. The fixed frame 330 does not move with the driving of the lifting drive 322 and the rotating drive 321. One of the guide column and the guide sleeve is connected to the fixed frame 330, and the other is connected to the connecting member 340, and the guide column is matched in the guide sleeve, and the guide column extends along the direction of the lifting of the connecting member 340, which is usually roughly vertical. Thus, when the lifting drive 322 drives the connecting member 340 to lift, the guide column also follows the lifting, and based on the cooperation with the guide sleeve, a guiding effect is achieved, so that the lifting of the connecting member 340 and the pick-and-place assembly 300 is more stable and aligned.

[0115] In some embodiments, see Figure 8 and Fig. 9 , a detection mechanism 600 may also be provided, and the detection mechanism 600 may be used to detect whether the liquid in the medicinal container 60 meets the preset standard. For example, the detection mechanism 600 may be a liquid weighing mechanism, a visual detection mechanism, etc., which is used to detect whether the weight of the liquid meets the preset standard or whether the liquid level meets the standard, etc. Exemplarily, the detection result of the detection mechanism 600 may be used to control the second feeding and conveying mechanism. Here, the detection mechanism 600 may be provided at the freeze-dried material removal mechanism 10, and when the freeze-dried material removal mechanism 10 is applied to a production line or other structures, the detection mechanism 600 may also be provided at other upstream positions of the freeze-dried material removal mechanism 10.

[0116] Thus, when it is detected according to the detection result of the detection mechanism that the liquid in the medicinal container 60 does not meet the preset standard, the freeze-dried material is not loaded for the corresponding medicinal container 60. For example, when two consecutive medicinal containers 60 meet the standard, the second loading and conveying mechanism is controlled to be in the first loading state; when the previous medicinal container 60 does not meet the standard and the next medicinal container 60 meets the standard, the second loading and conveying mechanism is controlled to be in the aforementioned second loading state; when the previous medicinal container 60 meets the standard and the next medicinal container 60 does not meet the standard, the second loading and conveying mechanism is controlled to be in the aforementioned third loading state; when two consecutive medicinal containers 60 do not meet the standard, the second loading and conveying mechanism is controlled to be in the fourth loading state.

[0117] Through this arrangement, it is possible to effectively implement the placement of freeze-dried materials only into the standard medicinal containers 60, while the non-standard medicinal containers 60 can be placed in the waste collection area more conveniently at the subsequent workstation, thereby reducing the loss of freeze-dried materials. For example, at the subsequent workstation, the non-standard medicinal containers 60 can be clamped by a robot or moved to the waste collection area by a conveyor line.

[0118] In some embodiments, since the freeze-dried material is placed in the freeze-drying mold and loaded, in order to collect the empty freeze-drying mold after the freeze-dried material is loaded, a freeze-drying mold collection tray 400 can also be provided at the end of the second loading and conveying mechanism, and the second loading and conveying mechanism can convey the empty freeze-drying mold to the freeze-drying mold collection tray 400.

[0119] Accordingly, in order to better achieve the technical effects of the embodiments of the present application, the embodiments of the present application also provide a dual-chamber pre-filled syringe production line. Fig.10 The dual-chamber prefilled syringe production line includes a medicinal container supply unit 20, a freeze-dried material supply unit 30, a filling unit 40 and a discharging unit 50. Of course, in some embodiments, it may also include only the filling unit 40.

[0120] The medicinal container supply unit 20 and the freeze-dried material supply unit 30 are both arranged upstream of the filling unit 40 , and the discharging unit 50 is arranged downstream of the filling unit 40 .

[0121] The medicinal container supply unit 20 is used to supply the medicinal container 60 to the filling unit 40, and the freeze-dried material supply unit 30 is used to supply the freeze-dried material to the filling unit 40. The filling unit 40 is used to charge the medicinal container 60, for example, to fill the medicinal container 60 with liquid components and to load the freeze-dried material into the medicinal container 60. The discharging unit 50 is used to assemble the medicinal container 60 pre-filled with liquid components and freeze-dried materials into a syringe and then discharge the materials.

[0122] Here, in some embodiments, the medicinal container supply unit 20 may also be used to unpack the outer package containing the medicinal container 60 to take out the medicinal container 60 in the outer package.

[0123] Exemplarily, the syringe supply unit includes an unpacking mechanism 21, a box sealing paper heating mechanism 22, a paper taking mechanism 23, a nesting plate taking mechanism 24 and a medicine container taking mechanism 25 which are arranged in sequence.

[0124] The medicinal container 60 is usually contained in an outer package, which includes an outermost packaging bag or packaging box, and a nest box is provided in the packaging bag or packaging box. The nest box is a honeycomb-shaped container, which has a plurality of accommodating positions arranged in an array, and each accommodating position contains a medicinal container 60. The nest box has a nest board that basically covers the nest box, and a sealing paper can also be provided on the nest board.

[0125] When in use, the unpacking mechanism 21 first removes the outer packaging bag or packaging box to take out the nest box. Then the sealing paper heating mechanism 22 heats the sealing paper so that the paper taking mechanism can tear the sealing paper off the nest box. After the sealing paper is torn off, the nesting plate taking mechanism 24 takes away the nesting plate, and then the medicinal container 60 in the nest box is exposed. Thus, the medicinal container taking mechanism 25 can take out the medicinal container 60 in the nest box.

[0126] The unpacking mechanism 21, the box sealing paper heating mechanism 22, the paper taking mechanism 23, the nesting plate taking mechanism 24 and the medicinal container taking mechanism 25 can be mechanisms including a robot, and of course existing mechanisms can also be used. For example, the unpacking mechanism 21 can be an existing automatic unpacking machine or a semi-automatic unpacking machine and other devices. This can be selected by those skilled in the art according to actual needs, and the examples in this embodiment do not constitute an undue limitation to it.

[0127] Here, according to actual needs, any of the unpacking mechanism 21, the box sealing paper heating mechanism 22, the paper picking mechanism 23 and the nesting plate mechanism 24 may not be provided. For example, when it is not necessary to remove the packaging bag or the packaging box, the unpacking mechanism 21 may not be provided. In the case where the unpacking mechanism 21, the box sealing paper heating mechanism 22, the paper picking mechanism 23 and the nesting plate mechanism 24 are not provided at the same time, the medicinal container supply unit 20 may basically only perform the operation of supplying the medicinal container 60 to the filling unit 40. The other operation steps may be performed manually or in advance by other equipment. It is understood that the examples in this embodiment do not constitute an improper limitation to the present application.

[0128] The freeze-dried material supply unit 30 is used to supply the freeze-dried material to the filling unit 40. Here, in some embodiments, the freeze-dried material supply unit 30 can also be used to achieve the preparation of the freeze-dried material.

[0129] Illustratively, the freeze-dried material supply unit 30 may include a loading subunit and a freeze-drying subunit.

[0130] Please continue to read Fig.10 The loading subunit may include a freeze-drying mold loading mechanism 31 , a front weighing mechanism 32 , a freeze-dried material filling mechanism 33 and a rear weighing mechanism 34 .

[0131] The freeze-drying mold loading mechanism 31 is used to load the freeze-drying mold, and the freeze-drying mold is used to accommodate the freeze-dried material later. After the freeze-drying mold is loaded with material, the front weighing mechanism 32 first weighs it once, and then the freeze-dried material filling mechanism 33 fills the freeze-dried material into the freeze-drying mold. After the freeze-dried material is filled, the rear weighing mechanism 34 weighs the freeze-drying mold filled with the freeze-dried material.

[0132] Here, the difference between the data weighed by the rear weighing mechanism 34 and the data weighed by the front weighing mechanism 32 is the weight of the filled liquid medicine. If the difference does not meet the preset weight range, the corresponding freeze-drying mold will be rejected before freeze-drying. For example, the processor 71 of the double-chamber pre-filled syringe production line records the position number of the freeze-drying mold that does not meet the requirements. When the freeze-drying mold is transported to the rejection station downstream of the rear weighing mechanism 34, the robot or other structure of the rejection station removes the freeze-drying mold from the production line.

[0133] The freeze-drying molds that meet the weighing requirements are transported to the freeze-drying subunit for freeze-drying operations.

[0134] Of course, in other embodiments, according to actual needs, any of the freeze-drying mold loading mechanism 31, the front weighing mechanism 32 and the rear weighing mechanism 34 may not be provided, and the examples in this embodiment do not constitute an undue limitation thereto.

[0135] Furthermore, the freeze-drying mold feeding mechanism 31 may be a material feeding tray, etc., and the filling mechanism 42 may include a filling pump, etc. Of course, the example of this embodiment does not constitute an undue limitation thereto, and other structures may also be used in other embodiments to achieve corresponding functions.

[0136] Please continue reading Fig.10 The freeze-drying subunit includes a freeze-drying loading mechanism 35, a freeze-drying mechanism 36 and a capping mechanism 37.

[0137] The aforementioned freeze-drying mold filled with freeze-dried material is transported to the freeze-drying feeding mechanism 35, which may be a push rod mechanism, etc., which transports the freeze-drying mold into the freeze-drying mechanism 36 for freeze-drying.

[0138] The freeze-drying mechanism 36 can be a freeze-drying machine, etc. The freeze-dried material is roughly in the shape of solid chalk, which can be called a powder cake. Of course, this embodiment does not limit its shape, etc. After the freeze-drying operation is completed, the freeze-dried material and the freeze-drying mold containing it can be transported to the filling unit 40 for subsequent operations.

[0139] Here, the capping mechanism 37 does not participate in the work, so in some embodiments, the capping mechanism 37 may not be provided. In other embodiments, in order to improve the applicability of the dual-chamber prefilled syringe production line, the capping mechanism 37 may be provided. Thus, the dual-chamber prefilled syringe production line can also be used to complete the production of other products. For example, the freeze-drying mold feeding mechanism 31 is used to feed the vials and other containers, and the freeze-dried material filling mechanism 33 is used to fill the vials and other containers with liquid medicine, and then the vials and other containers filled with liquid medicine are sent to the capping mechanism 37 for capping operation for storage and transportation.

[0140] It is understandable that in other embodiments, according to actual conditions, any of the loading subunit and the freeze-drying subunit may not be provided. For example, freeze-drying and other operations may be completed by other equipment. In this state, the double-chamber pre-filled syringe production line is not provided with a loading subunit and a freeze-drying subunit, and the double-chamber pre-filled syringe production line itself may not have a freeze-drying function, and it may only be used to load the freeze-dried material that has undergone the freeze-drying operation to the filling unit 40. The above example of this embodiment does not constitute an undue limitation to this application.

[0141] Here, please continue to read Fig.10 The filling unit 40 is used to fill the liquid component in the medicinal container 60 and load the freeze-dried material into the medicinal container 60.

[0142] Exemplarily, the filling unit 40 includes a liquid filling subunit and a freeze-dried material pre-filling subunit.

[0143] The liquid filling subunit includes a first sealing mechanism 41, a filling mechanism 42 and a second sealing mechanism 43 which are arranged in sequence.

[0144] The first sealing mechanism 41 is used to add a first sealing body into the medicinal container 60, the filling mechanism 42 is used to fill the space above the first sealing body with liquid, such as a diluent, and the second sealing mechanism 43 is used to add a second sealing body into the medicinal container 60. A liquid chamber for sealing the diluent is formed between the first sealing body and the second sealing body. It can be understood that for a dual-chamber prefilled syringe, one end of its communication channel is connected to the liquid chamber.

[0145] Here, the first sealing body and the second sealing body can be the same or different. For example, the first sealing body and the second sealing body are both rubber plugs, etc. Of course, in other embodiments, other structures can also be used without affecting the performance of the liquid therein and the subsequent freeze-dried material filled, such as wooden plugs, metal plugs, etc., as long as they can form a liquid chamber for containing liquid. The examples in this embodiment do not constitute an undue limitation to them.

[0146] In some embodiments, a first detection mechanism 44 may be provided, and the first detection mechanism 44 is used to detect whether the filling amount of the liquid meets the preset standard. The first detection mechanism 44 may be provided on the same side, opposite side, downstream, etc. of the filling mechanism 42, as long as it can detect the amount of the filled liquid. For example, the first detection mechanism 44 may include two liquid weighing mechanisms, which are respectively provided on the upstream and downstream of the filling mechanism 42, and the liquid amount of the filling is obtained by weighing before and after the filling. The examples in this embodiment do not constitute an improper limitation to it. In addition, in some embodiments, the detection result of the first detection mechanism 44 may be used to control the freeze-dried material pre-loading subunit downstream thereof, for example, the first detection mechanism 44 is used as the aforementioned detection mechanism of the freeze-dried material removal mechanism 10, and of course in other embodiments, another detection mechanism may be provided at the freeze-dried material removal mechanism 10, and the detection mechanism may also be a liquid weighing mechanism or other mechanism.

[0147] It is understandable that the liquid filling subunit may not be provided with the first sealing mechanism 41, for example, when the medicinal container 60 supplied to the liquid filling subunit is already provided with the first sealing body.

[0148] Please continue reading Fig.10 The freeze-dried material preloading subunit includes a first flipping mechanism 45, a freeze-dried material preloading machine 46 and a third sealing mechanism 47 which are sequentially arranged. The freeze-dried material preloading machine 46 can adopt the freeze-dried material removal mechanism 10 introduced in the above embodiment, and its structure has been specifically described in the above embodiment, so it will not be described in detail in this embodiment.

[0149] The first flipping mechanism 45 is used to flip the medicinal container 60 so that the side of the medicinal container 60 used for pre-loading the freeze-dried material faces the freeze-dried material removal mechanism 10. For example, the first flipping mechanism 45 is a manipulator, etc. Of course, in some embodiments, when it is not necessary to flip the medicinal container 60, the first flipping mechanism 45 may not be provided.

[0150] Here, the freeze-dried material removing mechanism 10 is arranged downstream of the liquid filling subunit. Of course, in other embodiments, it can also be arranged upstream of the liquid filling subunit.

[0151] It is understandable that in other embodiments, the filling unit 40 can also be used to load the freeze-dried material into the medicinal container 60 instead of filling the medicinal container 60 with liquid components. For example, when the medicinal container supply unit 20 supplies the medicinal container 60 that is already filled with liquid components to the pre-conversion unit, the example in this embodiment does not constitute an undue limitation thereto.

[0152] Here, as mentioned above, a third sealing mechanism 47 is further provided downstream of the freeze-dried material removal mechanism 10, and the third sealing mechanism 47 is used to provide a third sealing body for sealing the freeze-dried material in the medicinal container 60. In the embodiment provided with the first flipping mechanism 45, a chamber for accommodating the freeze-dried material is formed between the first sealing body and the third sealing body. It can be understood that for a double-chamber prefilled syringe, one end of its communication channel is connected to the liquid chamber, and the other end is connected to the chamber.

[0153] Here, the third sealing body can be a rubber plug, etc. Of course, in other embodiments, it can also adopt other structures, such as a wooden plug, a metal plug, etc., as long as it can form a chamber for accommodating freeze-dried materials. The example in this embodiment does not constitute an undue limitation to it.

[0154] In some embodiments, as mentioned above, for a double-chamber prefilled syringe, its medicinal container 60 has a liquid chamber for containing liquid and a chamber for containing freeze-dried material. Before the double-chamber prefilled syringe is used, the two chambers are not connected, otherwise the freeze-dried material will be mixed with the liquid in advance without need, thereby failing to achieve its function.

[0155] To this end, the double-chamber prefilled syringe production line is also provided with a third detection mechanism, which is located downstream of the freeze-dried material removal mechanism 10 and upstream of the third sealing mechanism 47, so as to detect the connection state between the liquid chamber for accommodating liquid and the chamber for accommodating freeze-dried material in the medicinal container 60. If the third detection mechanism detects that the two chambers of the medicinal container 60 are pre-connected, the medicinal container 60 will be removed as waste at the subsequent station. In this way, the yield rate of the double-chamber prefilled syringe can be improved. Here, the third detection mechanism can be a visual detection mechanism, an infrared detection mechanism, etc., and the examples in this embodiment do not constitute an undue limitation to it.

[0156] Here, in some embodiments, in order to improve the cleanliness of the environment, a laminar flow hood is provided, and the liquid filling subunit and the freeze-dried material pre-loading subunit are both arranged in the laminar flow hood and are in a Class A laminar flow environment, and the Class A laminar flow airflow moves in the direction from the liquid filling subunit to the freeze-dried material pre-loading subunit. Since the embodiment of the present application arranges the liquid filling subunit upstream of the freeze-dried material pre-loading subunit, it can better ensure the product yield. On the contrary, if the freeze-dried material pre-loading subunit is arranged upstream of the liquid filling subunit, since the particles of the freeze-dried material are easy to fall off, especially in a Class A laminar flow environment, the particles of the freeze-dried material are easily lifted up by the Class A laminar flow and form dust pollution, and are easy to fall into the downstream liquid, thereby resulting in a decrease in the product yield.

[0157] Here, please continue to read Fig.10 The discharging unit 50 is used to receive the medicinal container 60 from the filling unit 40. At this time, the medicinal container 60 has been pre-filled with liquid components and freeze-dried materials. The liquid component can be a diluent, and the freeze-dried material can be a powder. Then, the discharging unit 50 assembles the medicinal container 60 pre-filled with liquid components and freeze-dried materials into a syringe and then discharges the material.

[0158] Exemplarily, the discharging unit 50 may include an adapter mounting mechanism 51 , a top cap mounting mechanism 52 , a medicinal container flipping mechanism 53 , a back-push mounting mechanism 54 and a discharging mechanism 55 .

[0159] The medicinal container 60 has a first end and a second end opposite to each other. The adapter installation mechanism 51 first installs the adapter on the first end of the syringe, and the adapter provides the function of a switching joint. Then the top cap installation mechanism 52 installs a top cap on the adapter for protection.

[0160] Then, the flipping structure of the medicinal container 60 flips the medicinal container 60 by 180°, and the positions of the first end and the second end of the medicinal container 60 are reversed. The back push installation mechanism 54 can install the back push at the second end of the medicinal container 60. The back push is a flange structure protruding outward at the second end of the medicinal container 60. When the syringe is actually used, the operator can press the front side of the back push with the index finger and the middle finger, and press the push rod with the thumb to achieve injection. After the installation of the back push is completed, the medicinal container 60 becomes a syringe without the push rod and the needle installed, and the discharging mechanism 55 can discharge it into the finished product collection container.

[0161] The adapter mounting mechanism 51, the top cap mounting mechanism 52, the medicinal container flipping mechanism 53, the back push mounting mechanism 54 and the discharging mechanism 55 may be structures including a manipulator, etc. Of course, they may also be other structures, for example, the discharging mechanism 55 may be a discharging star wheel, etc.

[0162] It is understandable that in other embodiments, the discharging unit 50 may not be provided with any of the adapter installation mechanism 51, the top cap installation mechanism 52, the medicinal container flipping mechanism 53 and the back push installation mechanism 54. For example, when the second end of the medicinal container 60 does not need to be additionally installed with a back push, the medicinal container flipping mechanism 53 and the back push installation mechanism 54 may not be provided; for another example, by adjusting the setting position of the back push installation structure, it is not necessary to set the medicinal container flipping mechanism 53 and flip the medicinal container 60. For another example, other types of existing syringe manufacturing production lines usually also have structures that realize corresponding functions such as adapter installation, top cap installation and back push installation. The relevant structures can be used to realize the corresponding functions, and the double-chamber prefilled syringe production line itself may not have the corresponding functions. In short, the examples in this embodiment do not constitute an improper limitation to it.

[0163] In addition, in some embodiments, the dual-chamber prefilled syringe production line may also be provided with a conveying mechanism such as a mesh belt transfer mechanism or other conveying lines, and the conveying mechanism is used to realize material transportation between various units and / or between the mechanisms of each unit. The structure of the conveying mechanism itself and its application in various production lines are well known to those skilled in the art, and this embodiment does not impose any restrictions on it.

[0164] Combined with the above-mentioned settings, a complete double-chamber prefilled syringe production line can be provided, thereby realizing a series of steps such as unpacking the medicinal container 60, preparing the freeze-dried material, assembling the diluent and other liquids and freeze-dried materials into the medicinal container 60, and assembling the syringe, thereby effectively improving the production efficiency of the double-chamber prefilled syringe, and also helping to improve its production quality.

[0165] In some embodiments, the double-chamber prefilled syringe production line can also be used to produce other products. For example, it can be used to fill liquid medicine into vials and cap them. The aforementioned filling mechanism 42 or freeze-dried material filling mechanism 33 will be used. For the mechanisms that are not needed, conveying mechanisms such as conveyor lines can pass the vials through these mechanisms along the production line, and these mechanisms that are not needed will not work.

[0166] Accordingly, in order to better achieve the technical effect of the embodiment of the present application, the embodiment of the present application also provides a method for producing a double-chamber prefilled syringe, please refer to Fig.11 , which comprises the following steps:

[0167] S1. Loading the medicinal container 60 by the first loading conveying assembly 100;

[0168] S2. The freeze-dried material is fed through the second feeding conveying assembly 200;

[0169] S3. The freeze-dried material supplied by the second loading and conveying assembly 200 is transferred to the medicinal container 60 supplied by the first loading and conveying assembly 100 through the pick-and-place assembly 300 .

[0170] In some embodiments, the method for producing the dual-chamber prefilled syringe can be implemented based on the aforementioned dual-chamber prefilled syringe production line or a production line having the aforementioned freeze-dried material transfer mechanism 10 .

[0171] It is understandable that the sequence numbers of the steps in the embodiments of the present application do not necessarily represent the order of their implementation. For example, step S1 and step S2 can be implemented simultaneously, and the examples in this embodiment do not constitute an improper limitation to them.

[0172] Among them, in step S2, the second loading and conveying component 200 has four loading states. In the first loading state, the first loading position 241 and the second loading position 242 of the second loading and conveying component 200 both have freeze-dried materials; in the second loading state, the first loading position 241 does not have freeze-dried materials, and the second loading position 242 has freeze-dried materials; in the third loading state, the first loading position 241 has freeze-dried materials, and the second loading position 242 does not have freeze-dried materials; in the fourth loading state, both the first loading position 241 and the second loading position 242 have no freeze-dried materials.

[0173] In some embodiments, the loaded medicinal container 60 is detected by a detection mechanism and a detection result is obtained; in step S2, the loading state of the second loading conveying component 200 is switched according to the detection result.

[0174] In some embodiments, step S3 specifically includes:

[0175] S31. At the first station, the freeze-dried material supplied by the second loading and conveying assembly 200 is obtained by the pick-and-place assembly 300;

[0176] S33 . Rotate the pick-and-place assembly 300 to the third station and place the freeze-dried material in the medicinal container 60 .

[0177] In some embodiments, the following steps are further provided before step S33:

[0178] S32. Rotate the pick-and-place assembly 300 from the first station to the second station, and detect the freeze-dried material through the second detection mechanism 500.

[0179] In some embodiments, the following steps are further provided before step S33:

[0180] S34. Rotate the pick-and-place assembly 300 from the third station to the fourth station, and spray air outward at the fourth station to clean the air path of the pick-and-place assembly 300.

[0181] In some embodiments, before step S1, the following step is provided: filling the medicinal container 60 with liquid and forming a liquid chamber for containing the liquid.

[0182] In some embodiments, before step S1, the following step is provided: supplying a medicinal container 60 through the medicinal container supply unit 20. The medicinal container 60 is usually a medicinal container 60 that has been filled with liquid. The specific implementation example has been described in the above embodiment, and will not be repeated here.

[0183] In some embodiments, before step S2, the following step is provided: supplying freeze-dried material through the freeze-dried material supply unit 30. The specific implementation example has been described in the above embodiments, and will not be repeated here.

[0184] In some embodiments, after step S3, the medicinal container 60 pre-filled with the liquid component and the lyophilized material is assembled into a syringe by the discharging unit 50 and then discharged. The specific implementation example has been described in the above embodiment, and will not be repeated here.

[0185] Accordingly, in order to better achieve the technical effects of the embodiments of the present application, please refer to Fig.12 The embodiment of the present application also provides a control device 70 for a dual-chamber prefilled syringe production line, which includes a detection mechanism 600, a controller 71, and the aforementioned freeze-dried material transfer mechanism 10. The detection mechanism 600 is used to detect the loaded medicinal container 60 and obtain the detection result; the controller 71 is connected to the freeze-dried material transfer mechanism 10 and the detection mechanism 600 by signal, and the detection result is used to adjust the loading state of the second screw 240 of the freeze-dried material transfer mechanism 10.

[0186] For example, when the detection result is that two consecutive medicinal containers 60 both meet the standards, the controller controls the second loading and conveying mechanism to be in the first loading state; when the detection result is that the previous medicinal container 60 does not meet the standards and the next medicinal container 60 meets the standards, the second loading and conveying mechanism is controlled to be in the aforementioned second loading state; when the detection result is that the previous medicinal container 60 meets the standards and the next medicinal container 60 does not meet the standards, the second loading and conveying mechanism is controlled to be in the aforementioned third loading state; when the detection result is that two consecutive medicinal containers 60 do not meet the standards, the second loading and conveying mechanism is controlled to be in the fourth loading state.

[0187] In some embodiments, the controller controls the aforementioned double-chamber prefilled syringe production line to produce double-chamber prefilled syringes according to the aforementioned double-chamber prefilled syringe production method.

[0188] In some embodiments, the control device of the double-chamber prefilled syringe production line also includes a memory 72, which is used to store computer programs. The processor 71 and the memory 72 are connected by signals. When the computer program is executed by the processor 71, it is used to implement the aforementioned double-chamber prefilled syringe production method.

[0189] Accordingly, in order to better achieve the technical effects of the embodiments of the present application, the embodiments of the present application also provide a non-volatile computer-readable storage medium, on which a computer program is stored, and the computer program is executed by a processor to implement the steps in the aforementioned method for producing a double-chamber prefilled syringe.

[0190] The specific definition and implementation of the above steps can refer to the steps and methods of the embodiment of the production method of the double-chamber prefilled syringe, which will not be repeated here. A person of ordinary skill in the art can understand that all or part of the process in the above-mentioned embodiment method can be completed by instructing the relevant hardware through a computer program, and the relevant computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it may include the process of the embodiment of each method as described above. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application may include non-volatile and / or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM) or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0191] Application Examples

[0192] Here, an example of a dual-chamber prefilled syringe production line in actual use is provided. It should be understood that it does not constitute an undue limitation to the present application.

[0193] Here, the entire dual-chamber prefilled syringe production line is used under Class A laminar flow to ensure sterility.

[0194] First, the freeze-drying mold is placed on the freeze-drying mold loading mechanism 31, which may include a loading turntable, etc. The loading turntable rotates and works together with the guardrail on the loading turntable to arrange the freeze-drying molds into a single row. Then the freeze-drying mold is transported to the front weighing mechanism 32 to complete the front weighing.

[0195] The freeze-drying mold is then transported to the freeze-dried material filling mechanism 33, and the liquid medicine is filled into the freeze-drying mold through the freeze-dried material filling mechanism 33. The freeze-drying mold filled with liquid medicine is then sent to the rear weighing mechanism 34, and the difference between the data weighed by the rear weighing mechanism 34 and the data weighed by the front weighing mechanism 32 is the weight of the filled liquid medicine. The freeze-drying mold that does not meet the required filling amount will be discarded in the subsequent station. The freeze-drying mold that meets the requirements will be sent to the entrance of the freeze-drying mechanism 36 through the transfer mesh belt. The freeze-drying feeding mechanism 35 sends the freeze-drying mold into the freeze-drying mechanism 36. After the entire batch of liquid medicine is sent to the freeze-drying mechanism 36, the door of the freeze-drying mechanism 36 is closed and freeze-drying is carried out.

[0196] On the other hand, the whole package of medicinal containers 60 is sent to the unpacking mechanism 21 for unpacking and obtaining the nest box therein. The conveyor mesh belt conveys the nest box to the sealing paper heating mechanism 22, and the sealing paper heating mechanism 22 makes the sealing paper and the heating parts fully contact and heat, so that the paper picking mechanism 23 can take out the sealing paper. After heating, the conveyor mesh belt transfers the nest box to the paper picking mechanism 23, the paper picking mechanism 23 descends, and the sealing paper is taken off by the vacuum suction nozzle, and then the paper picking mechanism 23 rotates to the waste paper collection area, breaks the vacuum and puts the sealing paper into the waste paper collection device. After completing the removal of the sealing paper, the paper picking mechanism 23 rotates to the nest box again, descends, sucks the lining paper by the vacuum suction nozzle, and then rotates to the waste paper collection area after lifting and lowering, and places the lining paper in the waste paper collection device. Subsequently, the conveyor mesh belt conveys the nest box to the downstream equipment.

[0197] The conveyor mesh conveys the nest box to the nesting plate mechanism 24, which descends and takes the nest plate out of the nest box through the vacuum suction nozzle. The nest box mechanism rotates and descends, and places the nest plate in the nest plate transfer conveyor line. The nest plate transfer conveyor line transfers the nest plate to the nesting position, and the medicinal container mechanism 25 descends and sucks the medicinal container 60 through vacuum. Then the medicinal container mechanism 25 rises and takes the medicinal container 60 out of the nest plate, and at the same time, the medicinal container 60 is pulled apart. This mechanism rotates 180° and then descends, and the medicinal container 60 is placed in the double-layer transfer mesh belt of the medicinal container 60. Then the medicinal container mechanism 25 breaks the vacuum and then rises. The medicinal container transfer mesh belt transfers the medicinal container 60 to the downstream equipment.

[0198] After all the medicinal containers 60 are taken out, the nest plate transfer conveyor line transfers the empty nest plate to the nest box mechanism, which descends, takes out the empty nest plate and places it in the empty nest box. The empty nest box and the empty nest plate are pushed into the empty nest box collection mesh belt by the push-out mechanism in the conveyor mesh belt.

[0199] The medicinal container feeding transfer mesh belt transfers the medicinal container 60 after the upstream nesting to the main mesh belt, and the main mesh belt transfers the medicinal container 60 to the first sealing mechanism 41 for adding the intermediate rubber plug. The first sealing mechanism 41 adds the rubber plug into the medicinal container 60.

[0200] The medicinal container 60 with the intermediate rubber stopper is transported by the main mesh belt to the front weighing place of the second detection mechanism 500 for weighing.

[0201] Subsequently, the main mesh belt transports the medicinal container 60 to the filling mechanism 42 , and the filling mechanism 42 fills the diluent into the medicinal container 60 . The main mesh belt transports the medicinal container 60 to the post-weighing position of the second detection mechanism 500 for post-weighing.

[0202] Then, the main mesh belt transports the medicinal container 60 to the second sealing mechanism 43 for plugging. After plugging, the medicinal container 60 is transferred to the reject star wheel, which sucks the products without plugs and unqualified products by vacuum and transfers them to the reject channel, while the normal medicinal container 60 is transferred to the downstream equipment through the discharge star wheel.

[0203] The medicinal container 60 filled with diluent is transferred to the freeze-dried material removal mechanism 10 through the first feeding conveying assembly 100 such as a feeding star wheel and a mesh belt. The first flipping mechanism 45 removes the medicinal container 60 from the mesh belt, flips it 180° and puts it back on the mesh belt. The mesh belt transfers the medicinal container 60 to the front weighing position of the detection mechanism 600 to complete the weighing. The second feeding conveying assembly 200 including the transfer mesh belt transfers the freeze-dried finished product to the freeze-dried material removal mechanism 10. The freeze-dried material removal mechanism 10 of the 4-station descends and takes the freeze-dried material out of the freeze-drying mold through vacuum; then the freeze-dried material removal mechanism 10 rotates, transfers the freeze-dried material to the third station, and places the freeze-dried material in the medicinal container 60.

[0204] Subsequently, the mesh belt transports the medicinal container 60 to the rear weighing position of the detection mechanism 600 to complete the weighing. After completing the weighing, the mesh belt transports the medicinal container 60 to the third sealing mechanism 47 to complete the action of adding the front rubber plug. Subsequently, the mesh belt transports the finished product to the reject star wheel, which transports the medicinal container 60 without powder cake, powder cake weight unqualified, and without the front rubber plug to the reject channel through vacuum suction. The qualified products are transported to the discharging unit 50 for assembly through the discharging star wheel.

[0205] In the discharging unit 50 , the medicinal container 60 completes the installation of the adapter, the top cap, the back push, etc., and is then discharged by the discharging mechanism 55 .

[0206] It can be understood that, unless otherwise specified, the meanings of the terms in each embodiment of the present application are the same. For the content not described in detail in a certain embodiment, the specific implementation details can refer to the descriptions in other embodiments. The example descriptions and technical effects shown in the aforementioned embodiments can be implemented accordingly. For the repeated parts, this embodiment will not go into details.

[0207] The above is a detailed introduction to the freeze-dried material transfer mechanism, double-chamber prefilled syringe production line, production method, control device and storage medium provided by the present application. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method of the present application and its core idea; at the same time, for general technicians in this field, according to the ideas of the present application, there will be changes in the specific implementation methods and application scopes. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A freeze-dried material removal mechanism, characterized in that: include, A first loading and conveying assembly is used to load the medicinal container; A second loading and conveying assembly is used to load the freeze-dried material, the second loading and conveying assembly comprising a first driving mechanism, a second driving mechanism, and a first screw and a second screw that are coaxially arranged, the first driving mechanism is transmission-connected to the first screw, the second driving mechanism is transmission-connected to the second screw, and the first screw and the second screw are adjacently arranged along a conveying direction of the second loading and conveying assembly; as well as The pick-and-place assembly is used to transfer the freeze-dried material supplied by the second loading and conveying assembly to the medicinal container supplied by the first loading and conveying assembly.

2. The freeze-dried material removal mechanism according to claim 1, characterized in that: The second screw is provided with a first loading position and a second loading position, the first loading position is located downstream of the second loading position, and the second screw can adjust the loading state of the first loading position and the second loading position by switching the rotation frequency.

3. The freeze-dried material removal mechanism according to claim 2, characterized in that: The second screw can be switched between four feeding states, wherein: In a first loading state, both the first loading position and the second loading position have freeze-dried materials; In the second loading state, the first loading position does not have freeze-dried material, and the second loading position has freeze-dried material; In a third loading state, the first loading position has freeze-dried material, and the second loading position has no freeze-dried material; In a fourth loading state, neither the first loading position nor the second loading position has freeze-dried material.

4. The freeze-dried material removal mechanism according to claim 3, characterized in that: Also includes, A testing mechanism, used to test the loaded medicinal containers and obtain the test results; The second feeding and conveying component adjusts the feeding state of the second screw according to the detection result.

5. The freeze-dried material removal mechanism according to claim 3, characterized in that: The pick-and-place assembly includes a driving member and at least one group of pick-and-place units. The driving member is used to drive the pick-and-place units to move between the first loading and conveying assembly and the second loading and conveying assembly to load the freeze-dried material into the medicinal container.

6. The freeze-dried material removal mechanism according to claim 5, characterized in that: The driving member can drive the pick-and-place unit to switch between the first station and the third station; At the first station, at least one group of the pick-and-place units corresponds to the first loading position and the second loading position of the second screw to obtain the freeze-dried material; At the third station, at least one group of the pick-and-place units corresponds to the position of the first loading and conveying assembly to place the freeze-dried material in the medicinal container.

7. The freeze-dried material removal mechanism according to claim 6, characterized in that: The driving member can also drive the pick-and-place unit to a second station, where a second detection mechanism is provided for detecting the freeze-dried material.

8. The freeze-dried material removal mechanism according to claim 6, characterized in that: The driving member can also drive the pick-and-place unit to a fourth station, where the fourth station is a cleaning station.

9. The freeze-dried material removal mechanism according to claim 6, characterized in that: Each group of pick-and-place units includes two pick-and-place members, and the arrangement positions of the two pick-and-place members correspond to the arrangement positions of the first loading position and the second loading position.

10. The freeze-dried material removal mechanism according to claim 6, characterized in that: The driving member includes a rotating driving member, and the rotating driving member is transmission-connected to the pick-and-place unit to drive the pick-and-place unit to rotate and switch between the first station, the second station, the third station and the fourth station; The first workstation, the second workstation, the third workstation and the fourth workstation are evenly arranged in sequence along the circumferential direction.

11. The freeze-dried material removal mechanism according to claim 8 or 10, characterized in that: The pick-and-place unit includes at least one pick-and-place component, which is a vacuum adsorption component. A collection container is arranged at the fourth station to collect ejected matter when the pick-and-place component ejects air outward.

12. The freeze-dried material removal mechanism according to claim 11, characterized in that: The pick-and-place assembly is also provided with a central axis, a vacuum source and a bracket. The central axis is connected to the bracket through an air slip ring. The vacuum source gas is connected to the air slip ring. The air slip ring gas is connected to each of the vacuum adsorbents to provide positive pressure or negative pressure to each of the vacuum adsorbents.

13. The freeze-dried material removal mechanism according to claim 10, characterized in that: The pick-and-place assembly includes four groups of pick-and-place units, and the four groups of pick-and-place units are evenly arranged along the circumferential direction.

14. The freeze-dried material removal mechanism according to claim 10, characterized in that: The driving member further includes a lifting driving member, and the lifting driving member is connected to the pick-and-place unit and is used for driving the pick-and-place unit to lift and lower.

15. The freeze-dried material removal mechanism according to claim 14, characterized in that: It also includes a connecting member, the rotating drive member is arranged on the connecting member, the pick-and-place assembly has a central axis, the pick-and-place unit is connected to the central axis, the central axis is rotatably connected to the connecting member and is transmission-connected to the rotating drive member, and the lifting drive member is connected to the connecting member to drive the connecting member, the rotating drive member and the pick-and-place unit to rise and fall.

16. A double-chamber prefilled syringe production line, characterized in that: comprising a filling unit, the filling unit comprising, A first sealing mechanism, used to set a first sealing body in the medicinal container; A filling mechanism, disposed downstream of the first sealing mechanism, and used for filling liquid into the medicinal container; a second sealing mechanism, arranged downstream of the filling mechanism, the second sealing mechanism being used to arrange a second sealing body in the medicinal container, a liquid chamber for containing the liquid being formed between the first sealing body and the second sealing body; The freeze-dried material removal mechanism according to any one of claims 1 to 15, wherein the freeze-dried material removal mechanism is arranged downstream of the second sealing mechanism, and is used to add the freeze-dried material into the medicinal container; The third sealing mechanism is arranged downstream of the freeze-dried material removing mechanism, and is used to arrange a third sealing body in the medicinal container for sealing the freeze-dried material.

17. The double-chamber prefilled syringe production line according to claim 16, characterized in that: A first turning mechanism is further provided downstream of the second sealing mechanism and upstream of the freeze-dried material removing mechanism, and the first turning mechanism is used to turn over the medicinal container; A chamber for accommodating the freeze-dried material is formed between the first sealing body and the third sealing body.

18. The double-chamber prefilled syringe production line according to claim 16, characterized in that: It also includes a laminar flow hood, in which the first sealing mechanism, the filling mechanism, the second sealing mechanism and the freeze-dried material removing mechanism are arranged and are in a Class A laminar flow environment.

19. The double-chamber prefilled syringe production line according to claim 16, characterized in that: Also includes, a medicinal container supply unit, disposed upstream of the filling unit, for supplying medicinal containers to the filling unit; a freeze-dried material supply unit, disposed upstream of the filling unit, for supplying the freeze-dried material to the filling unit; as well as The discharging unit is arranged downstream of the filling unit and is used to assemble the medicinal containers pre-filled with liquid components and freeze-dried materials into syringes for discharging.

20. A method for producing a double-chamber prefilled syringe, characterized in that: The following steps are included: Loading the medicinal container by means of a first loading and conveying assembly; Loading the freeze-dried material through the second loading and conveying assembly; The freeze-dried material supplied by the second loading and conveying assembly is transferred to the medicinal container supplied by the first loading and conveying assembly by means of the pick-and-place assembly; Among them, the second loading and conveying assembly has four loading states. In the first loading state, the first loading position and the second loading position of the second loading and conveying assembly both have freeze-dried materials; in the second loading state, the first loading position does not have freeze-dried materials, and the second loading position has freeze-dried materials; in the third loading state, the first loading position has freeze-dried materials, and the second loading position does not have freeze-dried materials; in the fourth loading state, both the first loading position and the second loading position have no freeze-dried materials.

21. The method for producing a double-chamber prefilled syringe according to claim 20, characterized in that: The loaded medicinal containers are tested by a testing agency and the test results are obtained; The feeding state of the second feeding and conveying component is switched according to the detection result.

22. The method for producing a double-chamber prefilled syringe according to claim 20, characterized in that: The step of transferring the freeze-dried material supplied by the second feeding and conveying assembly to the medicinal container supplied by the first feeding and conveying assembly by means of the pick-and-place assembly specifically includes: At the first station, the freeze-dried material supplied by the second loading and conveying assembly is obtained by the pick-and-place assembly; The pick-and-place assembly is rotated to the third station, and the freeze-dried material is placed in a medicinal container.

23. The method for producing a double-chamber prefilled syringe according to claim 22, characterized in that: Before the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material in the medicinal container, the pick-and-place assembly is rotated to the second station and the freeze-dried material is detected by a second detection mechanism.

24. The method for producing a double-chamber prefilled syringe according to claim 22, characterized in that: The pick-and-place assembly removes the freeze-dried material by vacuum adsorption. After the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material in a medicinal container, the pick-and-place assembly is rotated to the fourth station and jets are sprayed outward at the fourth station to clean the air path of the pick-and-place assembly.

25. The method for producing a double-chamber prefilled syringe according to claim 20, characterized in that: Before the step of loading the medicinal container with the first loading and conveying assembly, the medicinal container is filled with liquid to form a liquid chamber for accommodating the liquid.

26. The method for producing a double-chamber prefilled syringe according to claim 20, characterized in that: Before the step of loading the medicinal container by the first loading and conveying assembly, supplying the medicinal container by the medicinal container supply unit; Before the step of loading the freeze-dried material through the second loading and conveying assembly, supplying the freeze-dried material through the freeze-dried material supply unit; After the step of transferring the freeze-dried material supplied by the second loading and conveying assembly to the medicinal container supplied by the first loading and conveying assembly through the pick-and-place assembly, the medicinal container pre-filled with liquid components and freeze-dried material is assembled into a syringe through the discharging unit and then discharged.

27. A control device for a double-chamber prefilled syringe production line, characterized in that: include, The freeze-dried material removal mechanism according to any one of claims 1 to 15; A testing mechanism, used to test the loaded medicinal containers and obtain the test results; The controller is connected to the freeze-dried material removal mechanism and the detection mechanism by signal, and adjusts the feeding state of the second screw of the freeze-dried material removal mechanism according to the detection result.

28. A non-volatile computer-readable storage medium, characterized in that: The non-volatile computer-readable storage medium stores a computer program, which is executed by a processor to implement the steps in the method for producing a dual-chamber prefilled syringe according to any one of claims 20 to 26.

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