Sample analyzer
Through the driving mechanism and detection components of the sample analyzer, the sample container type is identified and determined, and the detection abnormality caused by inconsistent sample container types is solved, and efficient sample processing and low-cost solution are achieved.
Patent Information
- Application Number
- CN202310809474.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-06-30
- Publication Date
- 2024-12-31
AI Technical Summary
When the sample analyzer deals with different types of sample containers, it is easy to cause detection abnormalities, such as errors in detection results, damage to the sample container, damage to the sample analyzer, sample loss, contamination, etc., which will affect the detection efficiency.
A sample analyzer is designed to drive the movement of the connector through a driving mechanism, so that the abutment member is retracted from the second position to the third position relative to the connector, and the sample container type is determined by using the detection parameters output by the detection component. The controller is based on the The detection parameters determine the sample container type, so that appropriate processing is performed to avoid detection of abnormalities.
Through simple mechanical structure and detection feedback, the identification of sample types is achieved, and the detection abnormality caused by sample container types is solved, which improves detection efficiency and reduces costs.
Smart Images

Figure CN119224344A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of medical devices, and in particular to a sample analyzer. Background Art
[0002] Sample analyzers can be used to analyze and detect various types of samples to obtain various indicators to assist in diagnosis / treatment. Samples are usually placed in sample containers and sent to the sample analyzer for various operations. Different sample containers are generally used to contain or circulate samples according to different sample types or analysis plans. Sample analyzers work differently for different types of sample containers. If the sample container type does not match the current working method of the sample analyzer, it is easy to cause detection abnormalities, such as incorrect test results, damage to the sample container, damage to the sample analyzer, sample loss, contamination, and other problems, thereby affecting detection efficiency. Summary of the invention
[0003] The present application aims to solve at least one of the technical problems existing in the prior art. To this end, the present application proposes a sample analyzer capable of determining the type of a sample container.
[0004] A sample analyzer according to an embodiment of the first aspect of the present invention comprises a sample position, a driving mechanism, a motion mechanism, a detection component and a controller, wherein the sample position is used to place a sample container, and the sample container is used to accommodate a sample; the motion mechanism comprises an abutment member, a connecting member and an elastic member, wherein the elastic member is connected between the abutment member and the connecting member, and an end of the connecting member facing away from the abutment member is connected to the driving mechanism so as to drive the connecting member to move to a first position through the driving mechanism, wherein when the connecting member is in the first position, the abutment member is located at a second position relative to the connecting member and the free end is located at a position where the sample container is located, and when the abutment member at the second position is acted upon by an external force, it retreats from the second position to a third position relative to the connecting member, and the third position is located between the second position and the first position; the detection component is used to output detection parameters, and when the abutment member is located at the second position and the third position, the detection parameters output by the detection component are different; and the controller is used to determine the type of the sample container at the sample position according to the detection parameters output by the detection component.
[0005] The sample analyzer according to the embodiment of the present invention has at least the following beneficial effects: the sample analyzer drives the connecting member to move to the first position through the driving mechanism, and the abutment member moves toward the sample position accordingly, and the abutment member can move from the second position to the third position relative to the connecting member through the abutment of the sample container at the sample position; based on the different types of sample containers at the sample position, different detection parameters can be output by the detection component; therefore, the controller can determine the type of sample container at the sample position based on the detection parameters, so that the sample analyzer can continue to perform subsequent processing on the sample container of the target type, effectively solving the detection anomaly caused by the non-compliance between the sample container and the target type, and the sample type can be identified through a simple mechanical structure and detection feedback, which is easy to implement and low in cost.
[0006] When the abutment member is located at the second position and the third position, the detection parameters output by the detection component have different categories, and the controller determines the type of the sample container at the sample position based on the category of the detection parameters.
[0007] In some embodiments of the present invention, the detection component includes an optical coupling sensor and a shielding member, one of the optical coupling sensor and the shielding member is connected to the abutment member, and the other is connected to the connecting member or fixed to the frame, and when the abutment member is located at the second position, the shielding member shields the optical coupling sensor, and when the abutment member is located at the third position, the optical coupling sensor and the shielding member are staggered; or, when the abutment member is located at the second position, the shielding member and the optical coupling sensor are staggered with each other, and when the abutment member is located at the third position, the shielding member shields the optical coupling sensor; the categories of detection parameters output by the optical coupling sensor are different when the optical coupling sensor is shielded by the shielding member and when the optical coupling sensor and the shielding member are staggered.
[0008] In some embodiments of the present invention, the movement mechanism also includes a detection member, which is arranged at the free end of the abutment member, and when the abutment member is located at the second position and the third position, the category of the signal output by the detection member is different; the controller is further configured to determine the sample container according to the category of the signal output by the detection member and the category of the detection parameter output by the detection component.
[0009] In some embodiments of the present invention, there are at least two third positions, and the distances between the two third positions and the first position are different; the sample analyzer is provided with at least two detection components, and one detection component is provided corresponding to each third position.
[0010] In some embodiments of the present invention, when the abutment member is located at the second position and the third position, the detection parameters output by the detection component are in different parameter ranges, and the controller determines the type of the sample container at the sample position based on the parameter range in which the detection parameters are located.
[0011] In some embodiments of the present invention, the detection component is a distance sensor, which is connected to the connecting member and / or the abutting member to detect the distance between the connecting member and the abutting member. When the connecting member is located at the first position, the controller obtains the detection parameter output by the distance sensor, and the detection parameter includes the distance; or, the detection component is a displacement sensor, which is connected to the abutting member. When the driving mechanism drives the connecting member to move to the first position, the controller obtains the output detection parameter, and the detection parameter includes the displacement of the abutting member.
[0012] In some embodiments of the present invention, there are at least two third positions, and when the abutment member is located at different third positions, the detection parameters output by the detection component are in different parameter ranges.
[0013] In some embodiments of the present invention, the controller determines that the type of the sample container at the sample position is one of a hard sample container, a soft sample container, and a microcup sample container based on the detection parameters output by the detection component; the hardness of the hard sample container is greater than that of the soft sample container, and / or the height of the microcup sample container is less than the heights of the hard sample container and the soft sample container, and a hollow containing frame is provided under the microcup sample container, and the free end of the abutment corresponds to the position of the hollow containing frame.
[0014] In some embodiments of the present invention, the elastic member includes a first section and a second section connected to each other, the first section and the second section are arranged in sequence along the movement direction of the abutment member, the elastic modulus of the first section of the elastic member is smaller than the elastic modulus of the second section of the elastic member, and one of the first section of the elastic member and the second section of the elastic member is connected to the connecting member.
[0015] In some embodiments of the present invention, the connecting member is provided with a through hole, and a limiting structure is provided between the connecting member and the abutting member, the limiting structure includes a limiting portion and a guiding portion, the limiting portion is located on the side of the connecting member away from the abutting member and can abut against the connecting member, the guiding portion is extended along the movement direction of the abutting member, one end of the guiding portion is connected to the abutting member, and the other end passes through the through hole and is connected to the limiting portion; the elastic member is a compression spring, the compression spring is sleeved on the outer periphery of the guide portion, and the compression spring abuts between the abutting member and the connecting member.
[0016] In some embodiments of the present invention, the sample analyzer also includes a cover opening mechanism, and the controller is at least used to control the cover opening mechanism to perform an open cover operation on the target type sample container to remove the cover of the sample container when the type of the sample container at the sample position is a target type based on the detection parameters output by the detection component, and the abutment member is located at a third position.
[0017] In some embodiments of the present invention, the sample analyzer also includes a sample transport mechanism, which is arranged at the sample position and is used to transport a sample rack, and the sample rack is used to carry a plurality of the sample containers. The controller is used to control the sample transport mechanism to transport the plurality of sample containers carried on the sample rack to move them sequentially to positions corresponding to the abutment member. When the type of the sample container is a target type, the controller controls the cover opening mechanism to remove the cover of the sample container. When the type of the sample container is not the target type, the controller controls the sample transport mechanism to continue transporting the next sample container to a position corresponding to the abutment member.
[0018] In some embodiments of the present invention, it also includes: a sample dispensing mechanism, which is used to absorb the sample in the sample container and discharge it into the reaction cup; a reagent dispensing mechanism, which is used to absorb the reagent and discharge it into the reaction cup; a mixing mechanism, which is used to mix the reaction liquid in the reaction cup, and the reaction liquid is formed by mixing at least the sample and the reagent; a reaction mechanism, which is used to place the reaction cup and incubate the reaction liquid in the reaction cup; a measuring mechanism, which is used to measure the reaction liquid after incubation to obtain the detection result of the sample; the controller is used to control the sample dispensing mechanism to absorb the sample in the sample container after the opening mechanism opens the cover of the target type sample container.
[0019] The second aspect of the present invention provides a sample analyzer, comprising a sample position, a driving mechanism, a motion mechanism, and a detection component; the sample position is used to place a sample container, and the sample container is used to accommodate the sample; the motion mechanism includes an abutment member, a connecting member, and an elastic member, the elastic member is connected between the abutment member and the connecting member, and the end of the connecting member facing away from the abutment member is connected to the driving mechanism, so that the connecting member is driven by the driving mechanism to move to a first position, when the connecting member is in the first position, the abutment member is located at a second position relative to the connecting member and the free end is located at the position of the sample container, and the abutment member in the second position retreats from the second position to a third position relative to the connecting member under the action of an external force, and the third position is located between the second position and the first position; the detection component is used to output detection parameters, and when the abutment member is in the second position and the third position, the detection parameters output by the detection component are different.
[0020] In some embodiments of the present invention, the detection component includes an optical coupling sensor and a shielding member, one of the optical coupling sensor and the shielding member is connected to the abutment member, and the other is connected to the connecting member or fixed to the frame, wherein when the abutment member is located at the second position, the shielding member shields the optical coupling sensor, and when the abutment member is located at the third position, the optical coupling sensor and the shielding member are staggered; or, when the abutment member is located at the second position, the shielding member and the optical coupling sensor are staggered with each other, and when the abutment member is located at the third position, the shielding member shields the optical coupling sensor, and the optical coupling sensor is used to detect whether the abutment member is located at the third position; or, the detection component is a distance sensor, the distance sensor is connected to the connecting member or the abutment member, and the distance sensor is used to detect the distance between the connecting member and the abutment member; or, the detection component is a displacement sensor, the displacement sensor is connected to the connecting member or the abutment member, and the displacement sensor is used to detect the relative displacement of the connecting member and the abutment member.
[0021] In some embodiments of the present invention, the sample analyzer further comprises a sample transport mechanism, a cover opening mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, a mixing mechanism, a reaction mechanism and a measuring mechanism; the sample transport mechanism is disposed at the sample position and is used to transport a sample rack, the sample rack being used to carry a plurality of sample containers, the sample transport mechanism being used to transport the plurality of sample containers carried on the sample rack and move them sequentially to positions corresponding to the abutment member, the detection component being used to output detection parameters when the driving mechanism drives the connecting member to move to the first position, the detection parameters being used to determine that the sample container corresponding to the abutment member is a target type; When the sample container at the sample position is not of the target type, the cover opening mechanism is used to remove the cover of the sample container when the abutment member abuts against the sample container; the sample dispensing mechanism is used to absorb the sample in the sample container and discharge it into the reaction cup; the reagent dispensing mechanism is used to absorb the reagent and discharge it into the reaction cup; the mixing mechanism is used to mix the reaction liquid in the reaction cup, and the reaction liquid is formed by mixing at least the sample and the reagent; the reaction mechanism is used to place the reaction cup and incubate the reaction liquid in the reaction cup; the measuring mechanism is used to measure the reaction liquid after incubation to obtain the detection result of the sample.
[0022] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] Figure 1 A schematic diagram of the sample analyzer components of an embodiment;
[0024] Figure 2 is a structural schematic diagram of a sample analyzer according to an embodiment;
[0025] Figure 3 It is a schematic diagram of the motion mechanism and some structures in the sample analyzer of the embodiment of the present invention;
[0026] Figure 4 for Figure 3 A partial schematic diagram of a top view of ;
[0027] Figure 5 for Figure 3 Schematic diagram of some structures in ;
[0028] Figure 6 for Figure 3 A schematic diagram of a state in which the connecting member is in a first position;
[0029] Figure 7 The motion mechanism and part of the structure of the sample analyzer in the embodiment of the present invention are located in Figure 6 Top view of the state;
[0030] Figure 8 for Figure 3 A schematic diagram of another state when the connecting member is in the first position;
[0031] Fig. 9 It is a schematic diagram of the detection member being in a non-pressed state when the connecting member is in the first position and the abutting member is in the third position in the embodiment of the present invention;
[0032] Fig.10 for Fig. 9 A schematic diagram showing that the detection member is in a pressed state when the middle connecting member is in the first position and the abutting member is in the third position;
[0033] Fig.11 for Fig. 9 A schematic diagram showing the middle connecting member being in the first position and the abutting member being in the third position;
[0034] Fig.12 This is a schematic diagram of a structure in which two detection components are arranged in an embodiment of the present invention;
[0035] Fig.13 for Fig.12 A top view of the illustrated embodiment and partial structure;
[0036] Fig.14 for Fig.12 A top view of the embodiment shown with the abutment member in a first third position;
[0037] Fig.15 for Fig.12The illustrated embodiment is a top view of the abutment member in the second third position.
[0038] Reference numerals:
[0039] Sample rack 2100, sample container;
[0040] Movement mechanism 2300, connecting member 2330, abutting member 2320, free end 2321, elastic member 2383, limiting portion 2386, telescopic rod 2340;
[0041] Driving mechanism 2310;
[0042] Optical coupler sensor 2400 , shielding member 2410 . DETAILED DESCRIPTION
[0043] The following will clearly and completely describe the concept of the present application and the technical effects produced in combination with the embodiments, so as to fully understand the purpose, features and effects of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of them. Based on the embodiments of the present application, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present application.
[0044] In the description of the embodiments of the present application, if orientation descriptions are involved, the orientations or positional relationships indicated by "up", "down", "front", "back", "left", "right", etc. are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or device referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on the present application.
[0045] In the description of the embodiments of the present application, if a feature is referred to as being “set,” “fixed,” “connected,” or “installed” on another feature, it may be directly set, fixed, or connected to another feature, or it may be indirectly set, fixed, connected, or installed on another feature. In the description of the embodiments of the present application, if “several” is involved, it means more than one; if “multiple” is involved, it means more than two; if “greater than,” “less than,” or “exceeds” is involved, it should be understood as not including the number itself; if “above,” “below,” or “within” is involved, it should be understood as including the number itself. If “first” or “second” is involved, it should be understood as being used to distinguish technical features, and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.
[0046] Please refer to Figure 1 and Figure 2, an embodiment discloses a sample analysis device, including at least one functional module 10 (or one or more functional modules 10), an input module 20, a display module 30, a memory 40, a processor 50 and an alarm module 60, which are described below respectively.
[0047] Each functional module 10 is used to complete at least one function required in the sample analysis process, and these functional modules 10 work together to complete the sample analysis and obtain the sample analysis results. Figure 2 , is a sample analysis device of an embodiment, in which some examples are given of the functional module 10. For example, the functional module 10 may include a sample component 11, a sample dispensing mechanism 12, a reagent component 13, a reagent dispensing mechanism 14, a mixing mechanism 15, a reaction component 16, and a light measuring component 17.
[0048] The sample component 11 is used to carry samples. In some examples, the sample component 11 may include a sample delivery module (SDM) and a front track; in other examples, the sample portion 10 may also be a sample tray, which includes a plurality of sample positions such as sample tubes, and the sample tray can dispatch samples to corresponding positions, such as positions for the sample dispensing mechanism 12 to absorb samples, by rotating its tray structure.
[0049] The sample dispensing mechanism 12 is used to absorb the sample and discharge it into the reaction cup to be loaded with the sample. For example, the sample dispensing mechanism 12 may include a sample needle, and the sample needle performs two-dimensional or three-dimensional movement in space through a two-dimensional or three-dimensional driving mechanism, so that the sample needle can move to absorb the sample carried by the sample component 11, and move to the reaction cup to be loaded with the sample, and discharge the sample into the reaction cup.
[0050] The reagent component 13 is used to carry the reagent. In one embodiment, the reagent component 13 may be a reagent disk, which is a disk-shaped structure with multiple positions for carrying reagent containers. The reagent component 13 can rotate and drive the reagent container it carries to rotate, and is used to rotate the reagent container to a specific position, such as a position where the reagent is sucked by the reagent dispensing mechanism 14. The number of the reagent components 13 may be one or more.
[0051] The reagent dispensing mechanism 14 is used to absorb the reagent and discharge it into the reaction cup to be added with the reagent. In one embodiment, the reagent dispensing mechanism 14 may include a reagent needle, which is moved in two dimensions or three dimensions in space by a two-dimensional or three-dimensional driving mechanism, so that the reagent needle can move to absorb the reagent carried by the reagent component 13, move to the reaction cup to be added with the reagent, and discharge the reagent into the reaction cup.
[0052] The mixing mechanism 15 is used to mix the reaction solution in the reaction cup. The number of the mixing mechanism 15 can be one or more.
[0053] The reaction component 16 has at least one placement position, and the placement position is used to place the reaction cup and incubate the reaction liquid in the reaction cup. For example, the reaction component 16 can be a reaction disk, which is arranged in a disc-shaped structure and has one or more placement positions for placing the reaction cup. The reaction disk can rotate and drive the reaction cup in its placement position to rotate, so as to arrange the reaction cup in the reaction disk and incubate the reaction liquid in the reaction cup.
[0054] The light measuring component 17 is used to perform light measurement on the reaction solution after incubation to obtain the reaction data of the sample. For example, the light measuring component 17 detects the luminous intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample through the calibration curve. In one embodiment, the light measuring component 17 is separately arranged outside the reaction component 16.
[0055] The above are some examples of the functional module 10 . The following will continue to describe other components and structures in the sample analysis device.
[0056] The input module 20 is used to receive user input. Generally, the input module 20 can be a mouse and a keyboard, etc. In some cases, it can also be a touch screen, which provides functions for user input and content display. Therefore, in this example, the input module 20 and the display module 30 are integrated together. Of course, in some examples, the input module 20 can even be a voice input device that recognizes voice.
[0057] The display module 30 can be used to display information. In some embodiments, the sample analysis device itself can be integrated with a display module. In some embodiments, the sample analysis device can also be connected to a computer device (such as a computer) to display information through a display unit (such as a display screen) of the computer device, which all fall within the scope defined and protected by the display module 30 herein.
[0058] Sample analyzers correspond to different types of samples or sample containers, and are generally adapted to different working modes. For example, some sample containers have closed lids, and the lids need to be removed before sampling, while some are open cup structures, and some are soft structures. The sampling methods of various types of sample containers are different. If the sample container type does not match the current sample analyzer working mode, it is easy to cause detection anomalies, such as wrong test results, damaged sample containers, damaged sample analyzers, sample loss, contamination, etc. In some technologies, the type of sample container is identified by configuring a visual recognition system, but the use of a visual recognition system for identification requires the use of auxiliary light sources, background boards and other components to establish a complex identification environment, which is not only costly, but also adds factors such as light sources that pose safety hazards, and there are certain safety risks.
[0059] The embodiment of the present application proposes a sample analyzer, which can effectively solve the problem of identifying the type of sample container, so as to facilitate the subsequent processing of the sample by the sample analyzer. The embodiment of the present invention is described in detail below in conjunction with the accompanying drawings of the specification:
[0060] refer to Figures 3 to 8 The embodiment of the present application proposes a sample analyzer, including a sample position, a driving mechanism 2310, a motion mechanism 2300, a detection component and a controller, wherein the sample position is used to place a sample container, and the sample container is used to contain a sample; the driving mechanism 2310 is used to drive the motion mechanism 2300 to move closer to or away from the sample position, the detection component is used to output detection parameters, and the controller is used to determine the type of sample container of the sample position according to the detection parameters output by the detection component.
[0061] The motion mechanism 2300 includes an abutment member 2320, a connecting member 2330 and an elastic member 2383, wherein the elastic member 2383 is connected between the abutment member 2320 and the connecting member 2330, and one end of the connecting member 2330 away from the abutment member 2320 is connected to the driving mechanism 2310, so that the connecting member 2330 is driven to move to the first position by the driving mechanism 2310. When the connecting member 2330 is in the first position, the abutment member 2320 is located at the second position relative to the connecting member 2330 and the free end is located at the position where the sample container is located. When the abutment member 2320 in the second position is acted upon by an external force, it retreats from the second position to a third position relative to the connecting member 2330, and the third position is located between the second position and the first position.
[0062] When the driving mechanism 2310 and the moving mechanism 2300 are in the initial position as a whole, the abutment member 2320 is at a certain distance from the position of the sample position for placing the sample container. In the case that the sample position does not have a sample container, the driving mechanism 2310 drives the connecting member 2330 to move toward the sample position to the first position, and the connecting member 2330 pushes the abutment member 2320 to move toward the sample position through the elastic member 2383. The abutment member 2320 can move to the second position and the free end of the abutment member 2320 can be located at the position for accommodating the sample container. In the case that the sample position has a target sample container, the abutment member 2320 abuts against the target sample container during the above movement, and can retreat to the third position relative to the connecting member 2330 under the abutment of the sample container. The second position and the third position of the abutment member 2320 relative to the connecting member 2330 can be detected by the detection component to output the detection parameter, so the controller can determine the type of the sample container at the sample position based on the detection parameter.
[0063] In the present embodiment, different types of sample containers may be sample containers of different heights and / or different materials. For a sample container with a relatively low height, the abutting portion cannot abut against the sample container, and the abutting portion will not receive an external force at this time, and will not retreat from the second position to the third position. For a sample container with a relatively high height, the abutting portion abuts against the sample container, and the abutting portion will receive an external force at this time, and will retreat from the second position to the third position. In this case, the detection parameters of different types of sample tube detection components are different, and the type of sample container at the sample position is determined according to the detection parameters output by the detection component; and for a sample container with a relatively soft material, the abutting portion cannot abut against the sample container, and the abutting portion will not receive an external force at this time or the external force received is relatively weak, and will not retreat from the second position to the third position. For a sample container with a relatively high hardness, the abutting portion abuts against the sample container, and the abutting portion will receive an external force at this time, and will retreat from the second position to the third position. In this case, the detection parameters of different types of sample tube detection components are different, and the type of sample container at the sample position is determined according to the detection parameters output by the detection component.
[0064] For ease of understanding, the different types of sample containers mentioned in the embodiments of the present invention can be simply divided into at least two types, such as sample containers with different heights and / or different materials on the top. Optionally, the types of sample containers may include a first type of sample container 2111, a second type of sample container, and a third type of sample container. In some embodiments of the present invention, the controller determines the type of sample container of the sample position based on the detection parameters output by the detection component, which may be one of a hard sample container, a soft sample container, and a micro-cup sample container; the hardness of the hard sample container is greater than that of the soft sample container, so the displacement of the abutment 2320 abutting against the hard sample container relative to the connector 2330 will be greater than the displacement of the abutment against the soft sample container relative to the connector 2330, thereby different detection parameters can be output through the detection component to achieve identification of the two. The height of the micro-cup sample container is less than the height of the hard sample container and the soft sample container, and a hollow accommodating frame is provided below the micro-cup sample container, and the free end of the abutment corresponds to the position of the hollow accommodating frame. Therefore, the abutment member 2320 can abut against the side of the hard sample container and the soft sample container and retreat relative to the connecting member 2330, but cannot abut against the micro-cup sample container and thus does not retreat, thereby the detection component can detect and output different detection parameters, thereby distinguishing the micro-cup sample container from the hard sample container and the soft sample container; or when the elastic member 2383 is relatively elastic and the material of the soft sample container is relatively soft, it abuts against the soft sample container and does not retreat, thereby distinguishing the hard sample container from the soft sample container and the micro-cup sample container. Hard sample containers, soft sample containers, and micro-cup sample containers are several types of sample containers commonly used in sample analyzers, among which the hard sample container can be provided with a lid to achieve the sealing of the sample, so when the sample analyzer needs to analyze the sample in the hard sample container, it needs to remove the lid first. As a reference, in some embodiments of the present invention, the first type of sample container 2111 can also be specifically understood as a hard sample container, the second type of sample container can be specifically understood as a soft sample container, and the third type of sample container can be specifically understood as a microcup sample container, and the specific types are only used as references for specific implementations.
[0065] According to different detection methods, the detection parameters output by the detection component may have different categories to reflect whether the abutment 2320 reaches the third position; or, the detection parameters output by the detection component may have different parameter ranges to reflect the relative position change between the abutment 2320 and the connecting member 2330.
[0066] In some embodiments, when the abutment 2320 is located at the second position and the third position, the detection parameters output by the detection component have different categories, and the controller determines the type of the sample container of the sample position based on the category of the detection parameter. For example, the detection component detects that the abutment 2320 is located at the third position and outputs the first category detection parameter, otherwise it outputs the second category detection parameter, and the controller determines that the sample position has the first type of sample container 2111 based on the first category detection parameter.
[0067] When implementing it, refer to Figure 5 The detection component may include an optical coupling sensor 2400 and a shielding member 2410, one of the optical coupling sensor 2400 and the shielding member 2410 is connected to the abutment 2320, and the other is connected to the connecting member 2330 or fixed to the frame, when the abutment 2320 is located at the second position, the shielding member 2410 shields the optical coupling sensor 2400, and when the abutment 2320 is located at the third position, the optical coupling sensor 2400 and the shielding member 2410 are staggered; or, when the abutment 2320 is located at the second position, the shielding member 2410 and the optical coupling sensor 2400 are staggered, and when the abutment 2320 is located at the third position, the shielding member 2410 shields the optical coupling sensor 2400; the categories of the detection parameters output by the optical coupling sensor 2400 being blocked by the shielding member 2410 and the optical coupling sensor 2400 and the shielding member 2410 being staggered are different. For example, when the abutment 2320 is located at the second position, the shielding member 2410 shields the optical coupling sensor 2400, and the optical coupling sensor 2400 outputs the second category detection parameter; when the abutment 2320 is located at the third position, the optical coupling sensor 2400 and the shielding member 2410 are staggered, and the optical coupling sensor 2400 outputs the first category detection parameter; or, when the abutment 2320 is located at the second position, the shielding member 2410 and the optical coupling sensor 2400 are staggered, and the optical coupling sensor 2400 outputs the second category detection parameter; when the abutment 2320 is located at the third position, the shielding member 2410 shields the optical coupling sensor 2400, and the optical coupling sensor 2400 outputs the first category detection parameter. The controller determines that the sample position has the first type of sample container 2111 based on the first category detection parameter. When the shielding member blocks the optocoupler sensor, the detection parameter of the optocoupler sensor not detecting the specific light output may be the first type of detection parameter, and when the shielding member and the optocoupler sensor are offset, the detection parameter of the optocoupler sensor detecting the specific light output may be the first type of detection parameter. The optional detection parameters may be 0 and 1.
[0068] During the implementation of this embodiment, the detection component can be used to detect whether the abutment 2320 is located at the third position, thereby confirming whether the sample position has the target sample container. Specifically, during the movement of the connecting member 2330 to the first position, the abutment 2320 retreats to the third position relative to the connecting member 2330 due to the abutment of the target sample container, thereby outputting the first category detection parameter through the detection component. The controller determines that the sample position has the first type of sample container 2111 based on the first category detection parameter, so as to adapt to the subsequent processing of the sample analyzer.
[0069] refer to Figures 9 to 11 In some embodiments, the motion mechanism 2300 may further include a detection member, which is disposed at the free end of the abutment member 2320. When the abutment member 2320 is located at the second position and the third position, the categories of the signal output by the detection member are different; the controller is further configured to determine the sample container according to the category of the signal output by the detection member and the category of the detection parameter output by the detection component. For example, the detection member can output a first signal when abutted, and output a second signal otherwise, wherein the controller determines that the sample position has a first type of sample container 2111 based on the first signal and the first category detection parameter; the controller determines that the sample position has a second type of sample container based on the first signal and the second category detection parameter; the controller determines that the sample position has a third type of sample container or does not have a sample container based on the second signal and the second category detection parameter.
[0070] In specific implementation, the detection member may include a telescopic rod 2340 and a first sensor, the first sensor is connected to the free end of the abutment member 2320, the telescopic rod 2340 is connected to the first sensor and extends toward the sample position, the driving mechanism 2310 drives the connecting member 2330 to move to the first position, the detection member located at the free end of the abutment member 2320 moves toward the sample position, the telescopic rod 2340 is suitable for retracting toward the abutment member 2320 under the action of the external force, the first sensor is used to output a first signal when the telescopic rod 2340 retracts toward the abutment member 2320, and output a second signal when the telescopic rod 2340 does not retract toward the abutment member 2320, wherein the first sensor can be a sliding rheostat, and its resistance value can be controlled by mechanical displacement (i.e., the telescopic displacement of the telescopic rod 2340) to achieve the measurement of the displacement parameter. The detection member may also be a pressure sensor, which is used to output a first signal when the connecting member 2330 is displaced to the first position and is pressed by an external force, and output a second signal when it is not pressed.
[0071] Take the detection component as the optical coupler sensor 2400 as an example:
[0072] refer to Fig. 9, the connecting member 2330 is located at the first position, the telescopic rod 2340 is not pressed, the abutting member 2320 is located at the second position, the first sensor outputs a second signal, the optical coupling sensor 2400 is not blocked and outputs a second category detection parameter, and the controller determines whether the sample position has a third type of sample container or does not have a sample container based on the second signal and the second category detection parameter;
[0073] refer to Fig.10 , the connecting member 2330 is located at the first position, the telescopic rod 2340 is pressed, the abutting member 2320 is located at the second position, the first sensor outputs a first signal, the optical coupling sensor 2400 is not blocked and outputs a second category detection parameter, and the controller determines that the sample position has a second type of sample container based on the first signal and the second category detection parameter;
[0074] refer to Fig.11 , the connecting member 2330 is located at the first position, the telescopic rod 2340 is pressed and the abutting member 2320 is located at the third position, the first sensor outputs a first signal, the optical coupling sensor 2400 is blocked and outputs a first category detection parameter, and the controller determines that the sample position has a first type of sample container 2111 based on the first signal and the first category detection parameter;
[0075] In the above embodiments, reference Figures 12 to 15 , the abutment member 2320 retreats to the third position relative to the connection member 2330, and can be configured to have at least two third positions, the two third positions are at different distances from the first position, and at least two of the above-mentioned detection components are provided, and each third position corresponds to a detection component. When the driving mechanism 2310 drives the connection member 2330 to move to the first position, the controller determines that the sample position has a first type of sample container 2111 based on two first category detection parameters; the controller determines that the sample position has a second type of sample container based on one first category detection parameter; the controller determines that the sample position has a third type of sample container, or does not have a sample container, based on the second category detection parameter.
[0076] refer to Figures 12 to 15 Taking the detection component as the optical coupling sensor 2400 as an example, the sample analyzer is provided with two optical coupling sensors 2400 and a shielding sheet, which are arranged along the movement direction of the abutment member 2320 (as shown in the left and right directions in the figure), and the shielding sheet is set corresponding to the light-emitting gap of the optical coupling. During identification:
[0077] refer to Fig.13 , when the connecting member 2330 is located at the first position, the abutting member 2320 is located at the second position, and the two optical coupling sensors 2400 are not blocked, and the second category detection parameters are output, the controller determines that the sample position has a third type of sample container or does not have a sample container based on the absence of the first category detection parameters and the second category detection parameters;
[0078] refer to Fig.14 When the connecting member 2330 is located at the first position, the abutting member 2320 is abutted and retracted to the first third position, the optical coupling sensor 2400 located on the right side is blocked and outputs a first category detection parameter, and the optical coupling sensor 2400 located on the left side is not blocked and outputs a second category detection parameter. The controller determines that the sample position has a second type of sample container based on a first category detection parameter;
[0079] refer to Fig.15 When the connecting member 2330 is located at the first position, the abutting member 2320 is abutted and retracted to the second third position, the two optical coupling sensors 2400 are blocked, and two first category detection parameters are output. The controller determines that the sample position has a second type sample container based on the two first category detection parameters.
[0080] In other embodiments of the present invention, when the abutment 2320 is located at the second position and the third position, the detection parameters output by the detection component are in different parameter intervals, and the controller determines the type of the sample container of the sample position based on the parameter interval of the detection parameters. For example, when the abutment 2320 is located at the third position, the detection parameters output by the detection component are in the first parameter interval, and when the abutment 2320 is located at the second position, the detection parameters output by the detection component are in the second parameter interval, and the first parameter interval and the second parameter interval are different from each other. The controller determines that the sample position has a first type of sample container 2111 based on the detection parameters being in the first parameter interval.
[0081] In a specific embodiment, the detection component may be a distance sensor, which is connected to the connecting member 2330 or the abutment 2320. When the connecting member 2330 is located at the first position, the distance sensor detects the distance between the connecting member 2330 and the abutment 2320 and outputs a detection parameter. The controller determines that the sample position has a first type of sample container 2111 based on the detection parameter being in the first parameter range. Specifically, the distance between the abutment 2320 and the connecting member 2330 at the third position is greater than the distance between the abutment 2320 and the connecting member 2330 at the second position. The distance sensor detects the distance between the connecting member 2330 and the abutment 2320 at the third position, and outputs a detection parameter in the first parameter range. The distance sensor detects the distance between the connecting member 2330 and the abutment 2320 at the second position, and outputs a detection parameter in the second parameter range. The distance sensor may also output a detection signal only when the detected detection parameter is in the first parameter range, that is, the detection signal is output when it is detected that the distance between the connecting member 2330 and the abutment 2320 is in the first parameter range. The controller determines that the sample position has a first type of sample container 2111 based on the detection parameter being in the first parameter range.
[0082] In a specific embodiment, the detection component can also be a displacement sensor, which is connected to the connecting member 2330 or the abutment 2320 and is used to detect the relative displacement of the connecting member 2330 and the abutment 2320. When the driving mechanism 2310 drives the connecting member 2330 to move to the first position, the displacement sensor detects the relative displacement of the connecting member 2330 and the abutment 2320 and outputs a detection parameter. The controller determines that the sample position has a first type of sample container 2111 based on the detection parameter being in the first parameter range. For example, the displacement sensor detects the relative displacement between the connecting member 2330 and the abutment 2320 located at the third position, and outputs the detection parameters in the first parameter range. The displacement sensor detects the relative displacement between the connecting member 2330 and the abutment 2320 located at the second position, and outputs the detection parameters in the second parameter range. The displacement sensor may also output a detection signal only when the detected detection parameter is in the first parameter range, that is, the detection signal is output when the relative displacement between the connecting member 2330 and the abutment 2320 is detected to be in the first parameter range. The controller determines that the sample position has the first type of sample container 2111 based on the detection parameters in the first parameter range.
[0083] In the above embodiment, the abutment 2320 retreats to the third position relative to the connection member 2330 and can be configured to have at least two third positions. When the detection component detects that the abutment 2320 is located at each third position, the detection parameter is outputted respectively. When the abutment 2320 is located at different third positions, the detection parameter outputted by the detection component is in different parameter intervals. When the driving mechanism 2310 drives the connection member 2330 to move to the first position, the controller determines that the sample position has a first type of sample container 2111 based on the detection parameter being in the first parameter interval, the controller determines that the sample position has a second type of sample container based on the detection parameter being in the second parameter interval, and the controller determines that the sample position has a third type of sample container or does not have a sample container based on the detection parameter being in the third parameter interval, wherein the second parameter interval is between the first parameter interval and the third parameter interval.
[0084] The sample analyzer of the embodiment of the present invention can identify one type of sample container from multiple types of sample containers, or identify two types of sample containers, or identify three types of sample containers, and can be configured according to actual detection requirements. Taking identifying one type of sample container from multiple types of sample containers as an example:
[0085] For example, taking the target sample type sample container as a hard sample container, in some usage scenarios, the sample analyzer needs to identify the hard sample container for subsequent operations, and needs to identify the hard sample container from other types of sample containers such as soft sample containers and micro-cup sample containers. In the process of the connecting member 2330 moving toward the sample position to the first position, the elastic member 2383 can be configured to be suitable for when the abutment member 2320 abuts against the hard sample container, the abutment member 2320 can overcome the elastic force of the elastic member 2383 and retreat to the third position, while when abutting against the soft sample container, the abutment member 2320 cannot overcome the elastic force of the elastic member 2383 and basically remain in the second position, so that the controller can identify the hard sample container from the hard sample container, the soft sample container and the micro-cup sample container through the different detection parameters detected by the detection component;
[0086] For another example, taking the target sample type sample container as a soft sample container, in some usage scenarios, the sample analyzer needs to identify the hard sample container for subsequent operation, and needs to identify the hard sample container from other types of sample containers such as soft sample containers and micro-cup sample containers. In the process of the connecting member 2330 moving toward the sample position to the first position, the elastic member 2383 can be configured to be suitable for when the abutting member 2320 abuts against the hard sample container, the abutting member 2320 can overcome the elastic force of the elastic member 2383 and retreat to the third position, and when abutting against the soft sample container, the abutting member 2320 cannot overcome the elastic force of the elastic member 2383 and basically remains in the second position, so the controller can identify the hard sample container from the hard sample container, the soft sample container and the micro-cup sample container through different detection parameters detected by the detection component.
[0087] In some embodiments of the present invention, the elastic member 2383 includes a first section and a second section connected to each other, the first section and the second section are extended along the movement direction of the abutment member 2320, the elastic modulus of the first section is smaller than the elastic modulus of the second section, and one of the first section and the second section is connected to the connection member 2330, so that when the abutment member 2320 abuts against sample containers of different hardness, it can have different retraction displacements, thereby forming at least two third positions, so that different detection parameters can be output by the detection component to achieve identification of multiple types of sample containers. Alternatively, the elastic member 2383 can also be provided with only one section, which can be suitable for being compressed and retracted by the abutment member 2320 when the abutment member 2320 abuts against a sample container of a softer material, and thus can also be suitable for having different retraction displacements when the abutment member 2320 abuts against sample containers of different hardness, thereby forming at least two third positions. When the abutment member 2320 abuts against the hard sample container and has a need for tightening, the elastic member 2383 can be configured as a structure with a larger elastic modulus. Therefore, when the current sample container is a soft sample container, the abutment member 2320 does not retract relative to the connecting member 2330. Thus, the detection component can detect the output detection parameters to reflect the retraction of the abutment member 2320 to identify whether the current sample container is a hard sample container, so as to meet the tightening demand for the hard sample container and facilitate subsequent corresponding processing.
[0088] In some embodiments, reference Figure 5 The elastic member 2383 is a compression spring. The connecting member 2330 is provided with a perforation. A limiting structure is provided between the connecting member 2330 and the abutting member 2320. The limiting structure includes a limiting portion 2386 and a guiding portion. The limiting portion 2386 is located on the side of the connecting member 2330 away from the abutting member 2320 and can abut against the connecting member 2330, thereby limiting the compression spring between the abutting member 2320 and the connecting member 2330. The compression spring is sleeved on the outer periphery of the guiding portion, and the two ends of the compression spring abut against the abutting member 2320 and the connecting member 2330 respectively. When the abutting member 2320 retreats relative to the connecting member 2330, the guiding portion is pushed to move along the perforation of the connecting member 2330 toward the retreat direction of the abutting member 2320, and the compression spring is further compressed; in the process of the driving mechanism 2310 driving the connecting member 2330 away from the sample position, the elastic force of the compression spring causes the abutting member 2320 to rebound. The guide portion is extended along the movement direction of the abutment 2320, one end of the guide portion is connected to the abutment 2320, and the other end passes through the through hole and is connected to the limiting portion 2386, so that the guide portion realizes the limiting and guiding of the compression spring.
[0089] In some embodiments, the sample analyzer further includes a cover opening mechanism, and when the type of the sample container is a target type (e.g., a hard sample container), the abutment member 2320 is located at a third position. The controller is at least used to control the cover opening mechanism to open the cover of the target type sample container to remove the cover of the sample container for subsequent sampling processing when the type of the sample container at the sample position is determined to be the target type according to the detection parameters output by the detection component. The sample analyzer of this embodiment can identify the type of sample container at the same station and perform a cover opening operation on the sample container determined to be the target type through the cover opening mechanism after the identification is completed. It can also identify the type of sample container and perform a cover opening operation of the cover opening mechanism at different stations, that is, after identifying the type, the sample is transported to another station through the sample transport mechanism, and the cover opening operation of the cover opening mechanism is controlled after the target type sample container is pressed against by a separately provided fixing mechanism.
[0090] In some embodiments, the sample analyzer also includes a sample transport mechanism, which is arranged at the sample position and is used to transport a sample rack 2100, and the sample rack 2100 is used to carry multiple sample containers. The controller is used to control the sample transport mechanism to transport the multiple sample containers carried on the sample rack 2100 to move them sequentially to positions corresponding to the abutment 2320. When the type of the sample container is the target type, the controller controls the cover opening mechanism to remove the cover of the sample container. When the type of the sample container is not the target type, the controller controls the sample transport mechanism to continue to transport the next sample container to the position corresponding to the abutment 2320.
[0091] In some embodiments, the sample analyzer further includes a sample dispensing mechanism, a reagent dispensing mechanism, a mixing mechanism, a reaction mechanism, and a measuring mechanism. The sample dispensing mechanism is used to absorb the sample in the sample container and discharge it into the reaction cup. The reagent dispensing mechanism is used to absorb the reagent and discharge it into the reaction cup. The mixing mechanism is used to mix the reaction liquid in the reaction cup, and the reaction liquid is at least formed by mixing the sample and the reagent. The reaction mechanism is used to place the reaction cup and incubate the reaction liquid in the reaction cup. The measuring mechanism is used to measure the reaction liquid after incubation to obtain the detection result of the sample.
[0092] The controller is used to control the sample dispensing mechanism to absorb the sample in the sample container and discharge it into the reaction cup after the cover opening mechanism performs the cover opening operation on the target type sample container. For example, the sample dispensing mechanism may include a sample needle and a first displacement mechanism for driving the sample needle to move, and the first displacement mechanism may be set as a two-dimensional or three-dimensional displacement platform. Driven by the first displacement mechanism, the sample needle can move to the opened sample container and absorb the sample inside the sample container; after absorbing the sample, the sample needle moves to the reaction cup to be loaded with the sample under the drive of the first displacement mechanism, and then discharges the sample into the reaction cup.
[0093] The controller is used to control the reagent dispensing mechanism to absorb the reagent and discharge it into the reaction cup. For example, the reagent dispensing mechanism may include a reagent needle and a second displacement mechanism for driving the reagent needle to move, and the second displacement mechanism may be set as a two-dimensional or three-dimensional displacement platform. Driven by the second displacement mechanism, the reagent needle can move to the reaction cup to be added with the reagent; then, the reagent needle discharges the reagent into the reaction cup. The reagent discharged by the reagent needle can be drawn from a container for storing the reagent of the reagent dispensing mechanism.
[0094] The controller is used to control the mixing mechanism to mix the reaction liquid in the reaction cup so that the sample and the reagent are fully mixed. The reaction liquid is at least a mixture of the sample and the reagent. The mixing mechanism can fix the reaction cup and drive the reaction cup to perform periodic motion, thereby achieving mixing of the reaction liquid.
[0095] The controller is used to control the reaction mechanism to place the reaction cup and incubate the reaction liquid in the reaction cup. The reaction mechanism has at least one placement position for placing the reaction cup, and after mixing, the reaction cup will be placed in the reaction mechanism.
[0096] The controller is used to control the detection mechanism to measure the reaction solution after incubation, so as to obtain the detection result. For example, the detection mechanism includes an instrument for measuring a certain component; for another example, the detection mechanism includes a light measuring component, which detects the luminous intensity of the reaction solution so that the detection mechanism can calculate the concentration of the component to be measured in the sample.
[0097] In one embodiment, the sample analyzer may further include a fixing mechanism. In a solution where the identification of the sample container type and the opening operation of the opening mechanism are performed at different stations, for example, an identification station and an opening station are respectively provided, and the fixing mechanism is used to fix the sample container at the opening station. The fixing mechanism may be provided with a plurality of sample positions for placing the sample container, and the fixing mechanism may clamp the sample container to fix the sample container. After the fixing mechanism fixes the sample container, the opening mechanism may clamp the cover and pull the cover upwards, thereby separating the cover from the sample container.
[0098] The second aspect of the present invention is a sample analyzer, a sample position, a driving mechanism 2310, a motion mechanism 2300, and a detection component; the sample position is used to place a sample container, and the sample container is used to accommodate the sample; the motion mechanism 2300 includes an abutment member 2320, a connecting member 2330 and an elastic member 2383, the elastic member 2383 is connected between the abutment member 2320 and the connecting member 2330, and the end of the connecting member 2330 away from the abutment member 2320 is connected to the driving mechanism 2310, so that the driving mechanism 2310 drives the connecting member 2330 to move the sample container. The connecting member 2330 moves to the first position. When the connecting member 2330 is in the first position, the abutting member 2320 is located at the second position relative to the connecting member 2330 and the free end is located at the position where the sample container is located. Under the action of external force, the abutting member 2320 in the second position retreats from the second position to the third position relative to the connecting member 2330. The third position is located between the second position and the first position. The detection component is used to output detection parameters. When the abutting member 2320 is located at the second position and the third position, the detection parameters output by the detection component are different. Therefore, the type of the sample container at the sample position can be determined by the controller according to the detection parameters output by the detection component.
[0099] In some embodiments, the detection assembly may include an optical coupling sensor 2400 and a shielding member 2410, one of which is connected to the abutment 2320, and the other is connected to the connection member 2330 or fixed to the frame, wherein the shielding member 2410 shields the optical coupling sensor 2400 when the abutment 2320 is in the second position, and the optical coupling sensor 2400 and the shielding member 2410 are staggered when the abutment 2320 is in the third position; or, the shielding member 2410 and the optical coupling sensor 2400 are staggered when the abutment 2320 is in the second position, and the shielding member 2410 shields the optical coupling sensor 2400 when the abutment 2320 is in the third position, and the optical coupling sensor 2400 is used to detect whether the abutment 2320 is in the third position. The optical coupling sensor 2400 can output detection parameters with different categories, thereby, the type of the sample container of the sample position can be determined by the controller based on the category of the detection parameter.
[0100] Alternatively, the detection component may be a distance sensor, which is connected to the connection member 2330 or the abutment member 2320, and is used to detect the distance between the connection member 2330 and the abutment member 2320; or, the detection component may be a displacement sensor, which is connected to the connection member 2330 or the abutment member 2320, and is used to detect the relative displacement between the connection member 2330 and the abutment member 2320. Thus, when the abutment member 2320 is located at the second position and the third position, the distance sensor or the displacement sensor may detect and output detection parameters in different parameter ranges, and thus, the type of the sample container at the sample position may be determined by the controller based on the parameter range of the detection parameter.
[0101] In some embodiments of the present invention, the sample analyzer further comprises a sample transport mechanism, a cover opening mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, a mixing mechanism, a reaction mechanism and a measuring mechanism; the sample transport mechanism is disposed at the sample position and is used to transport the sample rack 2100, the sample rack 2100 is used to carry a plurality of sample containers, the sample transport mechanism is used to transport the plurality of sample containers carried on the sample rack 2100 to positions corresponding to the abutment member 2320 in sequence, the detection component is used to output detection parameters when the driving mechanism 2310 drives the connecting member 2330 to move to the first position, the detection parameters being used to determine that the sample container corresponding to the abutment member 2320 is a target type;
[0102] The cover opening mechanism is used to remove the cover of the sample container when the sample container at the sample position is not of the target type, while the abutting member 2320 abuts against the sample container.
[0103] The sample dispensing mechanism is used to absorb the sample in the sample container and discharge it into the reaction cup. For example, the sample dispensing mechanism may include a sample needle and a first displacement mechanism for driving the sample needle to move, and the first displacement mechanism may be set as a two-dimensional or three-dimensional displacement platform. Driven by the first displacement mechanism, the sample needle can move to the opened sample container and absorb the sample inside the sample container; after absorbing the sample, the sample needle moves to the reaction cup to be loaded with the sample under the drive of the first displacement mechanism, and then discharges the sample into the reaction cup.
[0104] The reagent dispensing mechanism is used to absorb the reagent and discharge it into the reaction cup. For example, the reagent dispensing mechanism may include a reagent needle and a second displacement mechanism for driving the reagent needle to move, and the second displacement mechanism may be set as a two-dimensional or three-dimensional displacement platform. Driven by the second displacement mechanism, the reagent needle can move to the reaction cup to be added with the reagent; then, the reagent needle discharges the reagent into the reaction cup. The reagent discharged by the reagent needle can be drawn from a container for storing the reagent of the reagent dispensing mechanism.
[0105] The mixing mechanism is used to mix the reaction liquid in the reaction cup so that the sample and the reagent are fully mixed. The reaction liquid is at least a mixture of the sample and the reagent. The mixing mechanism can fix the reaction cup and drive the reaction cup to perform periodic motion, thereby achieving mixing of the reaction liquid.
[0106] The reaction mechanism is used to place the reaction cup and incubate the reaction liquid in the reaction cup. The reaction mechanism has at least one placement position for placing the reaction cup. After mixing, the reaction cup will be placed in the reaction mechanism.
[0107] The detection mechanism is used to measure the reaction solution after incubation to obtain the detection result. For example, the detection mechanism includes an instrument for measuring a certain component; for another example, the detection mechanism includes a light measuring component, which detects the luminous intensity of the reaction solution so that the detection mechanism can calculate the concentration of the component to be measured in the sample.
[0108] It can be seen from the above embodiments that the sample analyzer of the embodiment of the present invention can be used to identify different types of sample containers. The sample type can be identified through a simple mechanical structure and detection feedback. It has the advantages of simple structure, easy implementation, low cost and high safety.
[0109] The embodiments of the present application are described in detail above in conjunction with the accompanying drawings, but the present application is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in the relevant technical field without departing from the purpose of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.
Claims
1. A sample analyzer, characterized in that: include: A sample position, used for placing a sample container, wherein the sample container is used for containing a sample; Driving mechanism; A motion mechanism, comprising an abutment member, a connecting member and an elastic member, wherein the elastic member is connected between the abutment member and the connecting member, and one end of the connecting member facing away from the abutment member is connected to the driving mechanism, so that the connecting member is driven by the driving mechanism to move to a first position, when the connecting member is in the first position, the abutment member is located at a second position relative to the connecting member and the free end is located at a position where the sample container is located, and when the abutment member in the second position is acted upon by an external force, it retreats from the second position to a third position relative to the connecting member, and the third position is located between the second position and the first position; A detection component, used for outputting detection parameters, wherein the detection parameters output by the detection component are different when the abutment member is located at the second position and the third position; A controller is used to determine the type of the sample container of the sample position according to the detection parameter output by the detection component.
2. The sample analyzer according to claim 1, characterized in that: When the abutment member is located at the second position and the third position, the detection parameters output by the detection component have different categories, and the controller determines the type of the sample container at the sample position based on the category of the detection parameters.
3. The sample analyzer according to claim 2, characterized in that: The detection assembly includes an optical coupling sensor and a shielding member, one of the optical coupling sensor and the shielding member is connected to the abutment member, and the other is connected to the connecting member or fixed to the frame, and when the abutment member is located at the second position, the shielding member shields the optical coupling sensor, and when the abutment member is located at the third position, the optical coupling sensor and the shielding member are staggered; Alternatively, when the abutment member is located at the second position, the shielding member and the optical coupling sensor are staggered from each other, and when the abutment member is located at the third position, the shielding member shields the optical coupling sensor; When the optical coupling sensor is blocked by the blocking member and when the optical coupling sensor is offset from the blocking member, the categories of the detection parameters output by the optical coupling sensor are different.
4. The sample analyzer according to claim 2 or 3, characterized in that: The motion mechanism also includes a detection member, which is arranged at the free end of the abutment member. When the abutment member is located at the second position and the third position, the category of the signal output by the detection member is different; the controller is further configured to determine the sample container according to the category of the signal output by the detection member and the category of the detection parameter output by the detection component.
5. The sample analyzer according to claim 2, characterized in that: There are at least two third positions, and the distances between the two third positions and the first position are different; the sample analyzer is provided with at least two detection components, and one detection component is correspondingly provided for each third position.
6. The sample analyzer according to claim 1, characterized in that: When the abutment member is located at the second position and the third position, the detection parameters output by the detection component are in different parameter intervals, and the controller determines the type of the sample container at the sample position based on the parameter interval in which the detection parameters are located.
7. The sample analyzer according to claim 6, characterized in that: The detection component is a distance sensor, which is connected to the connecting member and / or the abutting member to detect the distance between the connecting member and the abutting member. When the connecting member is located at the first position, the controller obtains the detection parameter output by the distance sensor, and the detection parameter includes the distance; or The detection component is a displacement sensor, and the displacement sensor is connected to the abutment member. When the driving mechanism drives the connecting member to move to the first position, the controller obtains the output detection parameters, and the detection parameters include the displacement of the abutment member.
8. The sample analyzer according to claim 6, characterized in that: There are at least two of the third positions, and when the abutment member is located at different third positions, the detection parameters output by the detection component are in different parameter ranges.
9. The sample analyzer according to claim 7 or 8, characterized in that: The controller determines, based on the detection parameters output by the detection component, that the type of the sample container at the sample position is one of a hard sample container, a soft sample container, and a microcup sample container; the hardness of the hard sample container is greater than that of the soft sample container, and / or the height of the microcup sample container is less than the heights of the hard sample container and the soft sample container, and a hollow containing frame is provided below the microcup sample container, and the free end of the abutment member corresponds to the position of the hollow containing frame.
10. The sample analyzer according to claim 7 or 8, characterized in that: The elastic member includes a first section and a second section connected to each other, the first section and the second section are arranged in sequence along the movement direction of the abutment member, the elastic modulus of the first section of the elastic member is smaller than the elastic modulus of the second section of the elastic member, and one of the first section of the elastic member and the second section of the elastic member is connected to the connecting member.
11. The sample analyzer according to claim 1, characterized in that: The connecting member is provided with a through hole, and a limiting structure is provided between the connecting member and the abutting member, the limiting structure comprises a limiting portion and a guiding portion, the limiting portion is located at a side of the connecting member away from the abutting member and can abut against the connecting member, the guiding portion is extended along the movement direction of the abutting member, one end of the guiding portion is connected to the abutting member, and the other end passes through the through hole and is connected to the limiting portion; The elastic member is a compression spring, which is sleeved on the outer periphery of the guide portion and abuts between the abutting member and the connecting member.
12. The sample analyzer according to claim 1, characterized in that: The sample analyzer also includes a cover opening mechanism, and the controller is at least used to control the cover opening mechanism to open the cover of the target type sample container to remove the cover of the sample container when the type of the sample container at the sample position is determined to be a target type based on the detection parameters output by the detection component. When the type of the sample container is the target type, the abutment member is located at the third position.
13. The sample analyzer according to claim 12, characterized in that: The sample analyzer also includes a sample transport mechanism, which is arranged at the sample position and is used to transport a sample rack, and the sample rack is used to carry a plurality of the sample containers. The controller is used to control the sample transport mechanism to transport the plurality of sample containers carried on the sample component to move them sequentially to positions corresponding to the abutment members. When the type of the sample container is a target type, the controller controls the cover opening mechanism to remove the cover of the sample container. When the type of the sample container is not the target type, the controller controls the sample transport mechanism to continue transporting the next sample container to a position corresponding to the abutment member.
14. The sample analyzer according to claim 12, characterized in that: Also includes: A sample dispensing mechanism, used for sucking the sample in the sample container and discharging it into a reaction cup; A reagent dispensing mechanism, used for sucking the reagent and discharging it into the reaction cup; A mixing mechanism, used for mixing the reaction liquid in the reaction cup, wherein the reaction liquid is formed by mixing at least the sample and the reagent; A reaction mechanism, used for placing the reaction cup and incubating the reaction liquid in the reaction cup; A measuring mechanism, used to measure the reaction solution after incubation to obtain the test result of the sample; The controller is used to control the sample dispensing mechanism to absorb the sample in the sample container after the cover opening mechanism performs the cover opening operation on the target type sample container.
15. A sample analyzer, characterized in that include: A sample position, used for placing a sample container, wherein the sample container is used for containing a sample; Driving mechanism; A motion mechanism, comprising an abutment member, a connecting member and an elastic member, wherein the elastic member is connected between the abutment member and the connecting member, and one end of the connecting member facing away from the abutment member is connected to the driving mechanism, so that the connecting member is driven by the driving mechanism to move to a first position, when the connecting member is in the first position, the abutment member is located at a second position relative to the connecting member and the free end is located at a position where the sample container is located, and the abutment member in the second position retreats from the second position to a third position relative to the connecting member under the action of an external force, and the third position is located between the second position and the first position; The detection component is used to output detection parameters, and the detection parameters output by the detection component are different when the abutment member is located at the second position and the third position.
16. The sample analyzer according to claim 15, characterized in that: The detection component comprises an optical coupling sensor and a shielding member, wherein one of the optical coupling sensor and the shielding member is connected to the abutment member, and the other is connected to the connecting member or fixed to the frame, wherein when the abutment member is located at the second position, the shielding member shields the optical coupling sensor, and when the abutment member is located at the third position, the optical coupling sensor and the shielding member are staggered; or, when the abutment member is located at the second position, the shielding member and the optical coupling sensor are staggered, and when the abutment member is located at the third position, the shielding member shields the optical coupling sensor, and the optical coupling sensor is used to detect whether the abutment member is located at the third position; Alternatively, the detection component is a distance sensor, the distance sensor is connected to the connecting member or the abutting member, and the distance sensor is used to detect the distance between the connecting member and the abutting member; Alternatively, the detection component is a displacement sensor, the displacement sensor is connected to the connecting member or the abutting member, and the displacement sensor is used to detect the relative displacement between the connecting member and the abutting member.
17. The sample analyzer according to claim 15 or 16, characterized in that: The sample analyzer also includes: a sample transport mechanism, disposed at the sample position, for transporting a sample rack, the sample rack being used to carry a plurality of sample containers, the sample transport mechanism being used to transport the plurality of sample containers carried on the sample rack to positions corresponding to the abutment members in sequence, the detection component being used to output a detection parameter when the driving mechanism drives the connecting member to move to the first position, the detection parameter being used to determine that the sample container corresponding to the abutment member is a target type; a cover opening mechanism, when the sample container at the sample position is not of the target type, the cover opening mechanism is used to remove the cover of the sample container when the abutment member abuts against the sample container; A sample dispensing mechanism, used for sucking the sample in the sample container and discharging it into a reaction cup; A reagent dispensing mechanism, used for sucking the reagent and discharging it into the reaction cup; A mixing mechanism, used for mixing the reaction liquid in the reaction cup, wherein the reaction liquid is formed by mixing at least the sample and the reagent; A reaction mechanism, used for placing the reaction cup and incubating the reaction liquid in the reaction cup; The measuring mechanism is used to measure the reaction solution after incubation to obtain the detection result of the sample.
