Mosquito bite itching-relieving and swelling-eliminating emulsion for ball bottle and preparation method of mosquito bite itching-relieving and swelling-eliminating emulsion

Abstract

The invention discloses a mosquito bite itching relieving and swelling subsiding emulsion for a ball bottle and a preparation method thereof, the mosquito bite itching relieving and swelling subsiding emulsion for the ball bottle is alkaline and comprises potato starch, sweet potato starch, cassava starch, agarose, sodium alginate, sodium benzoate and a plant stock solution, and the plant stock solution is a long medicine eight-treasure stem and leaf extracting solution. The emulsion combines a plurality of natural components, the auxiliary material starch is low in cost, and the emulsion has good physical characteristics so as to be suitable for the use mode of the ball bottle, also has good itching relieving and detumescence effects, and can be kept stable in high-temperature and alkaline environments.

Description

Technical Field

[0001] The invention belongs to the technical field of daily chemical products, and in particular relates to an antipruritic and detumescent lotion for mosquito bites in a roller bottle and a preparation method thereof. Background Art

[0002] Mosquito bites are a common problem for people in daily life, especially in warm and humid seasons. When mosquitoes or other insects bite the human body, they inject saliva to prevent blood clotting, which often causes local skin redness, inflammation and intense itching, sometimes accompanied by mild pain. In addition to these discomforts, mosquito bites may also become a medium for the spread of diseases, such as malaria, dengue fever, yellow fever and Zika virus, which pose a potential threat to human health.

[0003] One of the mainstream products currently on the market that is widely used to relieve itching and swelling after mosquito bites is floral water. This product is mainly composed of ethanol (alcohol), water, menthol and essence, and contains a small amount of auxiliary ingredients such as chelating agents, antioxidants and pigments. It is necessary to point out that some floral water may also contain chemicals such as DEET or dimethyl phthalate (DMP). Although these ingredients help to repel mosquitoes, they are also considered to have certain toxicity. During use, people may absorb these ingredients into the body through skin contact or inhalation, especially for children, the potential risks of such products are greater. Long-term exposure to certain ingredients may cause asthma and other problems, and there is even a risk of cancer and teratogenicity.

[0004] Therefore, there is an urgent need for an antipruritic and detumescent lotion for mosquito bites in a roller bottle and a preparation method thereof to solve the deficiencies of the prior art problems. Summary of the invention

[0005] In view of the above problems, the purpose of the present invention is to provide a mosquito bite antipruritic and detumescent lotion for a roller bottle and a preparation method thereof. The lotion combines a variety of natural ingredients, and the auxiliary material starch has low cost and has good physical properties to be suitable for the use of a roller bottle. At the same time, the lotion also has good antipruritic and detumescent effects, and can remain stable under high temperature and alkaline environments.

[0006] To achieve the above objectives, the first aspect of the present invention provides an antipruritic and detumescent lotion for mosquito bites in a roller bottle, which is alkaline and includes potato starch, sweet potato starch, cassava starch, agarose, sodium alginate, sodium benzoate, and a plant stock solution, wherein the plant stock solution is an extract of the stems and leaves of the long medicine Babao.

[0007] Furthermore, the pH value of the mosquito bite antipruritic and detumescent emulsion of the present invention is 10.

[0008] Furthermore, the pH value of the antipruritic and detumescent lotion for mosquito bites of the present invention is adjusted to 10 by using sodium hydroxide. Specifically, the concentration of the sodium hydroxide solution is 2 mol / L.

[0009] Furthermore, in parts by mass, the potato starch is 0.25 parts, the sweet potato starch is 0.25 parts, the cassava starch is 0.5 parts, the agarose is 0.05 parts, the sodium alginate is 0.05 parts, the sodium benzoate is 0.4 parts, and the plant stock solution is 25 parts.

[0010] Furthermore, the antipruritic and detumescent lotion for mosquito bites of the present invention further comprises 75 parts of water.

[0011] Furthermore, the preparation of the plant stock solution of the present invention comprises the following steps:

[0012] (1) washing and drying the stems and leaves of the longevity wormwood and mixing them with 75% ethanol, and breaking the stems and leaves to obtain a slurry;

[0013] (2) filtering the slurry to obtain a filtrate;

[0014] (3) Add activated carbon to the filtrate, stir, decolorize, and filter to obtain the plant stock solution.

[0015] Furthermore, the mass ratio of the long medicinal herb Babao stems and leaves to 75% ethanol of the present invention is 1:5.

[0016] Furthermore, step (1) of the present invention comprises using a wall breaking machine with a rotation speed of 33000 to 36000 r / min to perform wall breaking treatment for 4 to 6 minutes.

[0017] Furthermore, in step (3) of the present invention, the ratio of the mass of activated carbon to the sum of the mass of the stems and leaves of the long medicine Babao and 75% ethanol is 0.02:1; and the decolorization time is 60 to 70 minutes.

[0018] Accordingly, the second aspect of the present invention also provides a method for preparing the above-mentioned antipruritic and detumescent lotion for mosquito bites in a roller bottle, the steps comprising:

[0019] (1) adding potato starch, sweet potato starch and tapioca starch to a portion of water and stirring to obtain a starch slurry;

[0020] (2) Add agarose and sodium alginate to another portion of water, stir evenly, then add the plant stock solution and sodium benzoate, stir evenly and heat to boiling, then add the starch slurry and stir until clear and transparent, then continue boiling for a certain period of time, stop heating, then adjust the volume and adjust the pH to alkaline.

[0021] Compared with the prior art, the antipruritic and detumescent lotion for mosquito bites in a roller bottle of the present invention has the following advantages:

[0022] Beneficial effects:

[0023] 1. The emulsion provided by the present invention is alkaline, which can neutralize the acidic substances output from the mouthparts after mosquito bites and reduce the itching sensation. However, alkalinity can cause slight irritation to the skin. Therefore, the present application also introduces potato starch, sweet potato starch, cassava starch, and sodium alginate. These substances can form colloidal solutions in water, provide buffering effects, and reduce the irritation of high pH values ​​to the skin.

[0024] 2. The emulsion provided by the present invention also uses the extract of the stems and leaves of the long-term medicine Babao as the plant stock solution, which contains a variety of active ingredients such as flavonoids, saponins and polysaccharide compounds, has significant anti-inflammatory and analgesic effects, and can effectively relieve itching and redness. Furthermore, the present application also introduces potato starch, sweet potato starch, cassava starch, sodium alginate, and agarose. These substances can form a protective film on the skin surface, keep the skin moist, reduce the impact of external irritants, and help the active ingredients penetrate into the skin better, thereby providing a lasting anti-itching and detumescence effect.

[0025] 3. Potato starch, sweet potato starch, cassava starch, sodium alginate and agarose of the present invention cooperate with each other to provide appropriate viscosity, so that the emulsion is neither too thin nor too viscous, and can flow smoothly in a roller bottle and be evenly distributed on the skin surface, and appropriate viscosity also enables the emulsion to adhere to the skin better. Potato starch and sweet potato starch both have good lubricity, so that the emulsion feels smooth when applied on the skin, and will not produce a sense of pulling. At the same time, sodium alginate further improves the smoothness, which improves the comfort when applied. Sodium alginate also has excellent water retention performance, which helps to lock the moisture in the skin. In addition, sweet potato starch, agarose and agarose all have good stability at high temperatures, and potato starch has good stability at high pH values. These substances cooperate with each other to enable the emulsion to remain stable under high temperature and alkaline environments. Therefore, the emulsion of the present invention has good physical properties (such as lubricity, viscosity, water retention, stability), is suitable for roller bottle packaging, and is convenient to carry and use. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 These are photos of the healthy growing Longyao Babao from June to September selected in Example 1. DETAILED DESCRIPTION

[0027] The following is a further detailed description of the claims of the present invention in conjunction with specific implementation methods, but does not constitute any limitation to the present invention. Any limited modifications made by anyone within the scope of protection of the claims of the present invention are still within the scope of protection of the claims of the present invention.

[0028] The invention provides a mosquito bite itching and swelling relief lotion for a roller bottle, which is alkaline and comprises potato starch, sweet potato starch, cassava starch, agarose, sodium alginate, sodium benzoate, and a plant stock solution, wherein the plant stock solution is a long-term medicine eight treasure stem and leaf extract. Specifically, the functions of each component are as follows.

[0029] Among them, the particle size of potato starch is larger than that of corn starch and wheat starch, which enables it to provide better texture and uniformity when forming a colloidal solution; the gelatinization temperature of potato starch is relatively low, making it easy to operate during processing. The gel formed by potato starch has high transparency and viscosity, which not only improves the appearance quality of the emulsion, but also enhances its adhesion and stability. In addition, the internal structure of potato starch particles is relatively loose and contains a high number of phosphate groups, which enables it to expand significantly after absorbing water, forming a denser and more stable colloidal structure, thereby improving the stability of the emulsion.

[0030] Among them, sweet potato starch has a thicker texture and larger particles than corn starch and wheat starch, contains more sugar, and can significantly increase the viscosity of the emulsion. In addition, sweet potato amylopectin is easier to regenerate than corn amylopectin, making it more suitable for high temperature and alkaline environments.

[0031] Among them, cassava starch has high yield and is widely planted, and its production cost is relatively low. Cassava starch paste has extremely high transparency, which can also improve the appearance quality of the emulsion; the gel structure formed by cassava starch is stable and not easy to stratify or deteriorate, which helps to extend the shelf life of the emulsion and maintain its consistency.

[0032] Among them, agarose is a polysaccharide compound that can form a high-viscosity gel in water, improve the consistency of the lotion, make it easier to apply and evenly distribute on the skin surface; agarose can also enhance the adhesion of the lotion, ensuring that the active ingredients stay on the skin longer to achieve the best effect. In addition, the gel structure formed by agarose is stable and not easy to stratify or deteriorate, which helps to extend the shelf life of the product.

[0033] Among them, sodium alginate, as a natural polysaccharide, is mild and non-irritating to the skin. Its high water absorption and water retention can form a moist protective film on the skin surface, locking in moisture and reducing dryness. In addition, sodium alginate has natural lubricity, which can improve the lubricity of the emulsion and significantly increase the viscosity of the emulsion to improve the stability and consistency of the emulsion.

[0034] Among them, sodium benzoate is mainly used as a preservative, but sodium benzoate also has a certain antibacterial effect, which can prevent bacterial infection and thus reduce itching and inflammation caused by infection.

[0035] Among them, the extract of stems and leaves of Longyao Babao in the plant essence contains a variety of active ingredients, such as flavonoids, saponins and polysaccharide compounds. These ingredients have significant anti-inflammatory and analgesic effects, can inhibit the release of inflammatory mediators, reduce itching and redness and swelling, and thus effectively relieve the discomfort symptoms after mosquito bites.

[0036] The preparation of the plant stock solution comprises the following steps:

[0037] (1) washing and drying the stems and leaves of the longevity wormwood and mixing them with 75% ethanol, and breaking the stems and leaves to obtain a slurry;

[0038] (2) filtering the slurry to obtain a filtrate;

[0039] (3) Add activated carbon to the filtrate, stir, decolorize, and filter to obtain the plant stock solution.

[0040] Wherein, step (1) includes selecting the stems and leaves of the long-grass babao that grow robustly between June and September.

[0041] Wherein, step (1) comprises using a wall-breaking machine with a rotation speed of 33000-36000 r / min to perform wall-breaking treatment for 4-6 minutes. Preferably, a wall-breaking machine with a rotation speed of 35000 r / min is used to perform wall-breaking treatment for 5 minutes at room temperature. Using a wall-breaking machine to break the stems and leaves of the long-term medicine eight treasures can more thoroughly crush and release its internal effective ingredients.

[0042] Wherein, step (2) comprises folding a single layer of 16-mesh medical gauze into four layers, and then filtering the slurry.

[0043] Wherein, the stirring in step (3) includes vigorous shaking by mechanical means, and the decolorization time is 60 to 70 minutes; preferably, the vigorous shaking time is 5 minutes, and the decolorization time is 60 minutes.

[0044] Wherein, in step (3), the ratio of the mass of activated carbon to the sum of the mass of the stems and leaves of Rhizoma Dioscoreae and 75% ethanol is 0.02:1.

[0045] Wherein, step (3) includes filtering with filter paper. Specifically, filter paper with a thickness of 0.2 mm and a size of 600 mm×600 mm can be cut to a suitable size for filtering. Decolorization and filtering can effectively prevent the color change of the emulsion caused by the decomposition of chlorophyll, thereby ensuring that the emulsion will not leave marks when applied on the skin.

[0046] The present invention also provides a method for preparing a mosquito bite antipruritic and detumescent lotion in a roller bottle, the steps comprising:

[0047] (1) adding potato starch, sweet potato starch and tapioca starch to a portion of water and stirring to obtain a starch slurry;

[0048] (2) Add agarose and sodium alginate to another portion of water, stir evenly, then add the plant stock solution and sodium benzoate, stir evenly and heat to boiling, then add the starch slurry and stir until clear and transparent, then continue boiling for a certain period of time, stop heating, then adjust the volume and adjust the pH to alkaline.

[0049] Wherein, in step (2), after adding starch slurry and stirring and boiling until it becomes clear and transparent, the boiling time can be continued for 4.5 to 6.5 minutes; the boiling time is preferably continued for 5 minutes.

[0050] Wherein, after stopping heating in step (2), water is added to make the volume to a predetermined volume.

[0051] In order to better illustrate the purpose, technical solutions and beneficial effects of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0052] Example 1

[0053] This embodiment provides a method for preparing a plant stock solution, comprising the following steps:

[0054] (1) Select the stems and leaves of the long-term medicine Babao that grows robustly between June and September (such as Figure 1 As shown), wash and dry the surface water, add the washed and dried long medicine eight treasure stems and leaves and 75% ethanol in a wall breaking machine at a mass ratio of 1:5, use 35,000 rpm and room temperature for wall breaking for 5 minutes to obtain a slurry;

[0055] (2) folding a single layer of 16-mesh medical gauze into four layers and filtering the slurry to obtain a filtrate;

[0056] (3) The filtrate is placed in a bucket with a lid, and then activated carbon powder is added. After the lid is closed and the mixture is shaken vigorously for 5 minutes, the mixture is decolorized for 60 minutes, and then filter paper with a thickness of 0.2 mm and a size of 600 × 600 mm is cut into a suitable size for filtration to obtain the plant extract.

[0057] Example 2

[0058] The present embodiment provides a mosquito bite antipruritic and detumescent lotion for a roller bottle, with a pH of 10, and comprises, by mass, 0.25 parts of potato starch, 0.25 parts of sweet potato starch, 0.5 parts of cassava starch, 0.05 parts of agarose, 0.05 parts of sodium alginate, 0.4 parts of sodium benzoate, 25 parts of the plant stock solution of Example 1, and 75 parts of water.

[0059] This embodiment provides a method for preparing a mosquito bite antipruritic and detumescent lotion in a roller bottle, the steps comprising:

[0060] (1) Add 2.5 g of potato starch, 2.5 g of sweet potato starch, and 5 g of tapioca starch to 200 mL of water, and stir to obtain a starch slurry;

[0061] (2) 0.5 g agarose and 0.5 g sodium alginate were added to 550 mL water, stirred evenly, and then 250 g of the plant stock solution of Example 1 and 4 g sodium benzoate were added. After stirring evenly, the mixture was heated to boiling. The starch slurry was added and stirred until it became clear and transparent, and then the mixture was boiled for 5 min. After stopping the heating, water was added to make the volume 1 L. After stirring evenly, the pH was adjusted to 10 with 2 mol / L sodium hydroxide, and the mixture was dispensed into roller bottles while hot.

[0062] Comparative Example 1

[0063] The comparative example provides a mosquito bite itching and swelling relief lotion for a roller bottle, with a pH of 10, which comprises, by mass, 0.25 parts of sweet potato starch, 0.5 parts of cassava starch, 0.05 parts of agarose, 0.05 parts of sodium alginate, 0.4 parts of sodium benzoate, 25 parts of the plant stock solution of Example 1, and 75 parts of water.

[0064] This comparative example provides a method for preparing a mosquito bite antipruritic and detumescent lotion in a roller bottle, the steps comprising:

[0065] (1) adding 2.5 g of sweet potato starch and 5 g of tapioca starch into 200 mL of water, and stirring to obtain a starch slurry;

[0066] (2) 0.5 g agarose and 0.5 g sodium alginate were added to 550 mL water, stirred evenly, and then 250 g of the plant stock solution of Example 1 and 4 g sodium benzoate were added. After stirring evenly, the mixture was heated to boiling. The starch slurry was added and stirred until it became clear and transparent, and then the mixture was boiled for 5 min. After stopping the heating, water was added to make the volume 1 L. After stirring evenly, the pH was adjusted to 10 with 2 mol / L sodium hydroxide, and the mixture was dispensed into roller bottles while hot.

[0067] Comparative Example 2

[0068] The comparative example provides a mosquito bite antipruritic and detumescent lotion for a roller bottle, with a pH of 10, which comprises, by mass, 0.25 parts of potato starch, 0.25 parts of sweet potato starch, 0.5 parts of cassava starch, 0.05 parts of agarose, 0.4 parts of sodium benzoate, 25 parts of the plant stock solution of Example 1, and 75 parts of water.

[0069] This comparative example provides a method for preparing a mosquito bite antipruritic and detumescent lotion in a roller bottle, the steps comprising:

[0070] (1) Add 2.5 g of potato starch, 2.5 g of sweet potato starch, and 5 g of tapioca starch to 200 mL of water, and stir to obtain a starch slurry;

[0071] (2) 0.5 g of agarose was added to 550 mL of water, and the mixture was stirred. Then, 250 g of the plant stock solution of Example 1 and 4 g of sodium benzoate were added. The mixture was stirred and heated to boiling. The starch slurry was added and stirred until it became clear and transparent, and the mixture was boiled for 5 min. After the heating was stopped, water was added to make the volume 1 L. The mixture was stirred and the pH was adjusted to 10 with 2 mol / L sodium hydroxide. The mixture was dispensed into roller bottles while hot.

[0072] Fluidity test of roller bottle: Open the roller bottles of Example 2 and Comparative Examples 1-2, and record the volume of liquid flowing out per second. If the volume of liquid flowing out per second is between 0.1 and 0.5 ml, it indicates that the emulsion is suitable for roller bottle packaging. The test results are shown in Table 1.

[0073] Fluidity test of roller bottle at 40°C: The roller bottles of Example 2 and Comparative Examples 1-2 were placed at 40°C for 1 month, and then the roller bottles were opened to record the volume of liquid flowing out per second. If the volume of liquid flowing out per second is between 0.1 and 0.5 ml, it means that the emulsion still has good stability under high temperature and alkaline environment. The test results are shown in Table 1.

[0074] Table 1

[0075] Group Liquidity test Fluidity test at 40°C Example 2 0.3mL 0.4mL Comparative Example 1 0.6mL 0.7mL Comparative Example 2 0.7mL 0.9mL

[0076] The following observations were made on the efficacy of the antipruritic and detumescent lotion for mosquito bites in the roller bottle of Example 2 of the present invention and Comparative Examples 1-2 in treating mosquito bites:

[0077] Subjects: 60 patients with mosquito bites were selected and randomly divided into the first group, the second group and the third group, with 20 people in each group. There was no statistically significant difference in age, gender, course of disease, etc. among the groups (P greater than 0.05), and they were comparable; the first group used the antipruritic and detumescent lotion for mosquito bites in a roller bottle of Example 2, and the second to third groups used the antipruritic and detumescent lotions for mosquito bites in roller bottles of Comparative Examples 1 and 2, respectively.

[0078] Qualified efficacy standards:

[0079] Cure—systemic and local symptoms disappear, and skin redness, swelling, heat, pain and itching subside.

[0080] Effective—systemic and local symptoms are relieved and swelling subsides.

[0081] Ineffective—systemic and local symptoms are not controlled or even aggravated.

[0082] Directions: After a mosquito bites your skin, open the roller bottle and apply the Anti-itch and Anti-swelling Lotion for Insect Bite to the red and swollen area of ​​your skin. The dosage should be adjusted according to the size of the lump. Apply twice a day. The treatment results are shown in Table 2.

[0083] Table 2

[0084] Group Cured (number of people) Effective (number of people) Invalid (number of people) Total effective rate (%) Example 2 18 2 0 100 Comparative Example 1 12 5 3 85 Comparative Example 2 11 5 4 80

[0085] It can be seen from Tables 1 and 2 that the antipruritic and detumescent lotion for mosquito bites of the present invention combines a variety of natural ingredients and has good physical properties to be suitable for use in a roller bottle. At the same time, the lotion also has good antipruritic and detumescent effects and can remain stable in high temperature and alkaline environments.

[0086] By comparing Example 2 with Comparative Examples 1 to 2, it can be seen that removing potato starch or sodium alginate will affect the physical properties, antipruritic and anti-edema effects and stability of the emulsion, which shows that the potato starch, sweet potato starch, cassava starch, sodium alginate and agarose of the present invention cooperate with each other to form a protective film on the skin surface, keep the skin moist, reduce the impact of external irritants, and help the active ingredients to better penetrate into the skin, thereby providing a lasting antipruritic and anti-edema effect; at the same time, potato starch, sweet potato starch, cassava starch, sodium alginate and agarose cooperate with each other to provide appropriate viscosity, so that the emulsion has good physical properties and can still remain stable under high temperature and alkaline environment.

[0087] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A mosquito bite itching and swelling relief lotion for a roller bottle, characterized in that: It is alkaline and includes potato starch, sweet potato starch, cassava starch, agarose, sodium alginate, sodium benzoate and plant stock solution. The plant stock solution is the extract of stems and leaves of Longyao Babao.

2. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 1, characterized in that: The pH value of the antipruritic and detumescent lotion for mosquito bites is 10.

3. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 2, characterized in that: The pH value of the antipruritic and detumescent lotion for mosquito bites was adjusted to 10 by using sodium hydroxide.

4. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 1, characterized in that: In parts by mass, the potato starch is 0.25 parts, the sweet potato starch is 0.25 parts, the cassava starch is 0.5 parts, the agarose is 0.05 parts, the sodium alginate is 0.05 parts, the sodium benzoate is 0.4 parts, and the plant stock solution is 25 parts.

5. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 4, characterized in that: Also included is 75 parts water.

6. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 1, characterized in that: The preparation of the plant stock solution comprises the following steps: (1) washing and drying the stems and leaves of the longevity wormwood and mixing them with 75% ethanol, and breaking the stems and leaves to obtain a slurry; (2) filtering the slurry to obtain a filtrate; (3) Adding activated carbon to the filtrate, stirring, decolorizing, and filtering to obtain the plant stock solution.

7. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 6, characterized in that: The mass ratio of the long medicinal herb Babao stems and leaves to the 75% ethanol is 1:

5.

8. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 6, characterized in that: Step (1) includes using a wall breaking machine with a rotation speed of 33000 to 36000 r / min to perform wall breaking treatment for 4 to 6 minutes.

9. The antipruritic and detumescent lotion for mosquito bites in a roller bottle as claimed in claim 6, characterized in that: In step (3), the ratio of the mass of the activated carbon to the sum of the mass of the stems and leaves of the long medicine Babao and the 75% ethanol is 0.02:1; and the decolorization time is 60 to 70 minutes.

10. The method for preparing the antipruritic and detumescent lotion for mosquito bites in a roller bottle according to any one of claims 1 to 9, characterized in that the steps include: (1) adding potato starch, sweet potato starch and tapioca starch to a portion of water and stirring to obtain a starch slurry; (2) Add agarose and sodium alginate to another portion of water, stir evenly, then add the plant stock solution and sodium benzoate, stir evenly and heat to boiling, then add the starch slurry, stir and boil until clear and transparent, then continue to boil for a certain period of time, stop heating, then adjust the volume and adjust the pH to alkaline.

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