Composition for cleaning or freshening hair or scalp and application thereof

Abstract

The invention discloses a composition for cleaning or refreshing hair or scalp and application thereof, the composition takes N-long-chain acyl amino acid and basic amino acid as main surfactants, can not contain a thickening agent, ethoxylate, fatty acid salt and a humectant, has the properties of low irritation, selective cleaning, easiness in washing, no stickiness and the like, and can be used for cleaning or refreshing hair or scalp. The shampoo is especially suitable for no-wash or dry-wash shampoo products.

Description

Technical Field

[0001] The present invention relates to the technical field of hair and scalp cleaning, in particular to a hair and scalp cleaning composition comprising N-long-chain acyl amino acids and basic amino acids as main surfactants, and application of the composition in related hair and scalp cleaning products. Background Art

[0002] Shampoo / hair shampoo is an indispensable product in people's daily life. With the continuous improvement of people's quality of life, the requirements for shampoo are constantly changing. Conventionally, anionic surfactants such as alkyl sulfates and polyoxyethylene alkyl sulfates have been widely used as surfactants for hair cleansing bases. However, with the increase in the frequency of shampooing in recent years, they may sometimes feel dry and irritating, so shampoos with less irritation are needed. In addition, these are petroleum-derived surfactants, which are contrary to the current sustainable development and environmental protection orientation.

[0003] 1. Sulfate surfactants

[0004] Most current shampoo products are based on sulfate-containing surfactants, such as sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), sodium laureth sulfate (SLES) or ammonium laureth sulfate (ALES). These sulfate surfactants combine the advantages of low price and satisfactory cleaning and foaming properties. However, as described in EP3582748A1, it is known that sulfate-containing surfactants (such as SLS) are prone to tolerance problems, especially on the skin and eyes. Another disadvantage of sulfate-containing surfactants is their tendency to strip the skin, scalp or hair of natural oils, fats or proteins contained at their surface. In the long run, repeated use of personal cleansing products containing sulfate-containing surfactants may cause irritation to the skin or scalp and / or damage to the hair fiber.

[0005] 2. Ethoxylated surfactants

[0006] The most typical ethoxylated surfactant is sodium laureth sulfate (SLES or AES). AES has strong cleaning power and can be easily thickened by adding sodium chloride (adding a large amount of sodium chloride to thicken is convenient, but sodium chloride can irritate the eyes), so it is widely used. Although it is milder than alkyl sulfate, it is still moderately irritating (see GB2598154A). In addition, ethoxylated surfactants contain a large amount of non-renewable carbon from ethylene oxide and have safety issues (dioxane contained in the surfactant is carcinogenic).

[0007] 3. Fatty acid salts

[0008] Fatty acid salts have been used as the main component of human body compositions, such as shower gels, hand soaps and facial cleansers, because they provide good foaming and a refreshing feeling. Fatty acid salts have good cleaning and foaming properties, but can only be made into products with high pH values ​​(>9.0), and they dry and irritate the skin, with a bad skin feel (see GB2598154A, EP3957297A1). Similarly, CN105997546B discloses a cleaning agent composition with fatty acid salts as the main component, which has the problem of tension and dryness peculiar to fatty acid salts after drying.

[0009] 4. Amino Acid Surfactants

[0010] The cosmetics and personal care industry has demonstrated the growing popularity and importance of “sulfate-free” and “dioxane-free” personal care cleaning products containing environmentally friendly, sustainable and mild surfactants. Amino acid-based surfactants are considered to be “greener”, milder and more sustainable than traditional petroleum-based surfactants.

[0011] The development of high-quality environmentally friendly surfactants has become the main direction of the surfactant industry, and the replacement of traditional petroleum-based surfactants with amino acid surfactants is the trend of industry development. Unilever announced that it would halve the use of petroleum-based products by 2025 and reduce the use of petroleum-based products to zero by 2030. L'Oreal announced that by 2030, 95% of petroleum-based products would be replaced. Therefore, it is very necessary to study the formulation system of amino acid surfactants as the main surfactant. Most of the current research focuses on the compounding of amino acid surfactants with traditional petroleum-based surfactants or the thickening of amino acid surfactants, and there are few studies on how to reduce skin irritation or eye irritation, improve easy-to-rinse performance, and control oil. In addition, if the traditional formulation method is used, acyl amino acid anionic surfactants as the main cleaning ingredients are easy to make consumers feel sticky (or sticky), which is also a generally undesirable feeling.

[0012] For some special groups, such as the elderly, patients, infants, women in confinement, travelers, business trippers, border guards, and everyday office workers who want to quickly clean or refresh their hair, wash-free or dry-cleaning shampoo products are particularly important. It is known to treat hair with aerosol shampoo that does not contain surfactants but contains solvents and propellants. The shampoo is sprayed on the hair using an aerosol device. Once the solvent evaporates, the starch particles contained in the dry shampoo will absorb sebum and dirt and be brushed off after the reaction time. However, the hair washed with aerosol shampoo has poor silkiness and fluffiness, and even has the disadvantages of hair adhesion after washing, powdery crumbs that are difficult to comb out and remove, and white / gray residues. In addition, for environmental protection and safety reasons, the use of propellants should be avoided.

[0013] At present, more and more families keep cats and dogs as pets. Cats and dogs have more and longer hair, which is easy to be stained with dirt and carry a variety of pathogens. Pets' skin is also often troubled by skin diseases. Pet cleaning products on the market are easy to cause irritation to pets, and cannot meet the requirements of dry cleaning or no-cleaning. When washing, the amount of water is large, the number of washing times is large, and the washing time is long, and the pets may not cooperate.

[0014] There is a demand for cleansing compositions for hair that have not only high cleansing power but also low irritation to eyes and scalp and excellent feeling during use. Summary of the invention

[0015] In view of this, on the one hand, an object of the present invention is to provide a composition for cleaning or refreshing hair or scalp, wherein the surfactants contained in the composition are mainly N-long-chain acyl amino acids and basic amino acids, and the composition has the properties of low irritation, selective cleaning / decontamination, easy rinsing, and non-stickiness.

[0016] In another aspect, the present invention provides a leave-in or dry shampoo product.

[0017] In yet another aspect, the present invention is directed to a method for reducing scalp or eye irritation in a shampoo.

[0018] In another aspect, the present invention provides a method for improving the easy-rinsing performance or water-saving performance in a shampoo.

[0019] In yet another aspect, the present invention provides a method for improving deodorizing performance in a shampoo.

[0020] In a final aspect, the present invention aims to provide a method for imparting oil control properties to a shampoo.

[0021] Specifically, the scheme of the present invention is as follows.

[0022] [1] A composition for cleaning or refreshing hair or scalp, characterized in that it comprises (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%;

[0023] The main surfactant is composed of N-long-chain acyl amino acid and basic amino acid; preferably, the weight percentage of N-long-chain acyl amino acid in the composition is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the composition is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%;

[0024] Alternatively, the main surfactant is composed of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid; preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide in the composition is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the composition is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%;

[0025] Preferably, the weight percentage of the co-surfactant in the composition is 0 to 10 wt %, preferably 0 to 5 wt %, more preferably 0 to 1 wt %.

[0026] [2] The composition according to [1], which contains substantially no thickener, preferably no thickener at all;

[0027] and / or, substantially free of sodium chloride, preferably completely free of sodium chloride;

[0028] and / or, substantially free of sulfates, preferably completely free of sulfates;

[0029] and / or, substantially free of ethoxylates, preferably completely free of ethoxylates;

[0030] and / or, substantially free of fatty acid salts, preferably completely free of fatty acid salts;

[0031] And / or, substantially no polyol humectant is contained, preferably no polyol humectant is contained.

[0032] [3] According to the composition described in any one of [1] to [2], the co-surfactant comprises one or more of a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a sodium salt, potassium salt, or TEA salt of an N-long-chain acylamino acid.

[0033] [4] The composition according to any one of [1] to [3], wherein the co-surfactant contains substantially no nonionic surfactant, and preferably contains no nonionic surfactant at all.

[0034] [5] The composition according to any one of [1] to [4], wherein the co-surfactant contains substantially no cationic surfactant, and preferably contains no cationic surfactant at all.

[0035] [6] The composition according to any one of [1] to [5], wherein the co-surfactant contains substantially no amphoteric surfactant, and preferably contains no amphoteric surfactant at all.

[0036] [7] The composition according to any one of [1] to [6], wherein the weight percentage of the co-surfactant in the composition is 0 wt%, that is, the weight percentage of the main surfactant in all surfactants is 100 wt%.

[0037] [8] The composition according to any one of [1] to [7], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated linear or branched fatty acid having 8 to 22 carbon atoms;

[0038] And / or, the amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, lysine, and (methyl)taurine.

[0039] [9] The composition according to any one of [1] to [8], wherein the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

[0040] And / or, the amino acid in the N-long-chain acylamino acid is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl)taurine, preferably alanine, most preferably L-alanine.

[0041]

[10] According to any one of [1] to [9], the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and / or lysine, most preferably arginine.

[0042]

[11] The composition according to any one of [1] to

[10] , wherein the N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

[0043] And / or, the amino acids in the N-long-chain acyl amino acid dipeptide are derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, and (methyl)taurine, preferably alanine, and most preferably L-alanine.

[0044]

[12] The composition according to any one of [1] to

[11] , wherein the N-long-chain acyl amino acid dipeptide is selected from one or more of N-long-chain acyl glycylglycine, N-long-chain acyl glutamyl glutamate, N-long-chain acyl alanyl alanine, and N-long-chain acyl sarcosyl sarcosine, preferably N-long-chain acyl alanyl alanine, and most preferably N-lauroyl-L-alanyl-L-alanine.

[0045]

[13] The composition according to any one of [1] to

[12] , wherein the weight percentage of the N-long-chain acyl amino acid dipeptide in the composition is greater than 0.1 wt %, preferably greater than 0.3 wt %, more preferably greater than 0.5 wt %;

[0046] And / or, the weight ratio of N-long-chain acyl amino acid to N-long-chain acyl amino acid dipeptide is 20:1 to 1.5:1, preferably 15:1 to 3:1, more preferably 10:1 to 6:1.

[0047]

[14] The composition according to any one of [1] to

[13] , wherein the basic amino acid is present in an amount to partially neutralize the N-long-chain acyl amino acid, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and less than 96%;

[0048] Alternatively, the basic amino acid is present in an amount to partially neutralize the N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and 96% or less.

[0049]

[15] The composition according to any one of [1] to

[14] , further comprising (d) a preservative, wherein the preservative is benzoic acid.

[0050]

[16] The composition according to any one of [1] to

[15] , further comprising (e) a flavor or fragrance, wherein the composition is preferably clear after the flavor or fragrance is added.

[0051]

[17] The composition according to any one of [1] to

[16] , wherein the composition does not contain a cationic polymer; and / or the composition does not contain silicone oil.

[0052]

[18] The composition according to any one of [1] to

[17] , wherein the pH of the composition is 5-7.5, preferably 5.5-6.9, more preferably 6-6.7;

[0053] And / or, the composition has a low viscosity, wherein the low viscosity means that the viscosity at 25° C. is lower than 150 mPa·s, preferably lower than 120 mPa·s, more preferably lower than 100 mPa·s.

[0054]

[19] The composition according to any one of [1] to

[18] , wherein the composition has a specified cloth detergency, as measured in accordance with QB / T1224-2012 Liquid Detergents for Clothing, with a JB-01 of 0.8 or more, preferably 0.85 or more, and more preferably 0.9 or more;

[0055] and / or, JB-02 is above 0.8, preferably above 0.85, more preferably above 0.9;

[0056] And / or, JB-03 is 0.4 or more and 0.8 or less, preferably 0.45 or more and 0.75 or less, and more preferably 0.5 or more and 0.7 or less.

[0057]

[20] The composition according to any one of [1] to

[19] , wherein the foam performance of the composition in hard water is better than that in soft water; and / or, under hard water conditions, the foam volume in 30s, 3min and 5min is more than 400ml, preferably more than 450ml, more preferably more than 500ml; the aforementioned test standard: GB / T7462-1994 "Determination of Foaming Power of Surfactants - Improved Ross-Miles Method", test instrument: Model 2152 Improved Ross Foam Tester.

[0058]

[21] A composition according to any one of [1] to

[20] , comprising (a) a primary surfactant, (c) water, a preservative and a flavor; wherein the primary surfactant comprises an N-long-chain acyl amino acid and a basic amino acid, the weight percentage of the N-long-chain acyl amino acid in the composition is 5-7wt%, and the weight percentage of the basic amino acid in the composition is 3-5wt%; or, the primary surfactant comprises an N-long-chain acyl amino acid, an N-long-chain acyl amino acid dipeptide and a basic amino acid, the total weight percentage of the N-long-chain acyl amino acid and the N-long-chain acyl amino acid dipeptide in the composition is 5-7wt%, and the weight percentage of the basic amino acid in the composition is 3-5wt%;

[0059] Preferably, the preservative is benzoic acid.

[0060]

[22] Use of the composition described in any one of [1] to

[21] in a disposable cleaning product or a dry cleaning product.

[0061]

[23] A leave-in or dry shampoo comprising the composition described in any one of [1] to

[21] .

[0062]

[24] A pet cleaning agent comprising the composition described in any one of [1] to

[21] .

[0063]

[25] A shampoo for infants or the elderly, comprising the composition described in any one of [1] to

[21] .

[0064]

[26] A method for reducing scalp irritation or eye irritation in a shampoo, the shampoo comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %;

[0065] The method for reducing scalp irritation or eye irritation comprises: selecting a main surfactant to be composed of N-long chain acyl amino acid and basic amino acid; preferably, the weight percentage of N-long chain acyl amino acid in the shampoo is 1 to 12 wt%, preferably 4 to 8 wt%, more preferably 5 to 7 wt%, and the weight percentage of basic amino acid in the shampoo is 0.5 to 8 wt%, preferably 2 to 5.5 wt%, more preferably 3 to 5 wt%;

[0066] Alternatively, the main surfactant is selected to be composed of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid; preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide in the shampoo is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the shampoo is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%.

[0067]

[27] The method for reducing scalp irritation or eye irritation in a shampoo according to

[26] , wherein the shampoo comprises the composition according to any one of [1] to

[21] .

[0068]

[28] A method for improving easy-rinsing performance or water-saving performance in a shampoo, the shampoo comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %;

[0069] The method for improving easy-rinsing performance or water-saving performance comprises: selecting a main surfactant to be composed of N-long-chain acyl amino acids and basic amino acids;

[0070] Alternatively, the primary surfactant is selected to consist of an N-long chain acyl amino acid, an N-long chain acyl amino acid dipeptide and a basic amino acid.

[0071]

[29] The method for improving the easy-rinsing performance or water-saving performance in a shampoo according to

[28] , wherein the shampoo comprises the composition according to any one of [1] to

[21] .

[0072]

[30] A method for improving deodorizing performance in a shampoo, the shampoo comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %;

[0073] The method for improving the deodorizing performance comprises: selecting a primary surfactant to be composed of an N-long-chain acyl amino acid and a basic amino acid, wherein the basic amino acid is present in an amount that partially neutralizes the N-long-chain acyl amino acid, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and less than 96%;

[0074] Alternatively, the main surfactant is selected to be composed of N-long-chain acyl amino acids, N-long-chain acyl amino acid dipeptides and basic amino acids, and the basic amino acids are present in an amount to partially neutralize the N-long-chain acyl amino acids and N-long-chain acyl amino acid dipeptides, preferably with a neutralization degree of more than 85% and less than 100%, and more preferably with a neutralization degree of more than 88% and less than 96%.

[0075]

[31] The method for improving the deodorizing performance in a shampoo according to

[30] , wherein the shampoo comprises the composition according to any one of [1] to

[21] .

[0076]

[32] A method for imparting oil control properties to a shampoo, the shampoo comprising (a) a primary surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the primary surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %;

[0077] The method for imparting oil control properties to shampoo comprises: selecting a primary surfactant to be composed of N-long-chain acyl amino acids and basic amino acids;

[0078] Alternatively, the primary surfactant is selected to consist of an N-long chain acyl amino acid, an N-long chain acyl amino acid dipeptide and a basic amino acid.

[0079]

[33] The method for imparting oil control properties to a shampoo according to

[32] , wherein the shampoo comprises the composition according to any one of [1] to

[21] .

[0080] Compared with the prior art, the present invention has beneficial technical effects:

[0081] 1. N-long-chain acyl amino acids and basic amino acids are used as the main surfactants, and the amount of surfactants is limited to a reasonable range, so that the composition has the properties of low irritation, selective cleaning / decontamination, and non-stickiness.

[0082] 2. By selecting specific primary surfactants, especially the combination of N-long-chain acylamino acids (optionally dipeptides) and basic amino acids, nonionic surfactants, cationic surfactants and amphoteric surfactants can be substantially eliminated.

[0083] 3. The present invention unexpectedly found that benzoic acid has very good antiseptic properties and compatibility in the system of the present invention, and its irritation is lower than other preservatives such as sodium benzoate.

[0084] 4. The composition of the present invention can achieve a relatively excellent decontamination effect and even selective decontamination without containing traditional petroleum-based surfactants.

[0085] 5. The present invention is the first to discover that selecting a main surfactant consisting of an N-long-chain acyl amino acid (optionally a dipeptide) and a basic amino acid without adding a thickener can reduce scalp irritation or eye irritation.

[0086] 6. The present invention finds that by selecting a specific primary surfactant, the easy-rinsing performance or water-saving performance can be improved, and even dry cleaning or water-free washing can be achieved.

[0087] 7. The present invention surprisingly found that when the degree of neutralization is above 85% and less than 100%, the composition system contains a small amount of unneutralized N-long-chain acyl amino acid and / or N-long-chain acyl amino acid dipeptide, which has a very good effect on removing odor.

[0088] 8. The present invention first discovered that selecting a primary surfactant consisting of an N-long-chain acylamino acid (optionally a dipeptide) and a basic amino acid can impart oil control properties to the composition. BRIEF DESCRIPTION OF THE DRAWINGS

[0089] Figure 1 This is a graph showing the results of a makeup removal test using an aqueous solution of sodium lauroyl glutamate, an aqueous solution of potassium cocoyl glycinate, and an aqueous solution of sodium lauroyl sarcosinate in Example 4, wherein ① is a comparison before and after treatment with an aqueous solution of sodium lauroyl glutamate; ② is a comparison before and after treatment with an aqueous solution of potassium cocoyl glycinate; and ③ is a comparison before and after treatment with an aqueous solution of sodium lauroyl sarcosinate.

[0090] Figure 2 This is a graph showing the results of a makeup removal test using the lauroyl alanine arginine aqueous solution in Example 4; ④ in the figure is a comparison before and after treatment with the lauroyl alanine arginine aqueous solution.

[0091] Figure 3 This is a diagram showing the results of the foam test in Example 5.

[0092] Figure 4The foam conditions of the rinsing liquid in Example 7. A1 and A2 are the foam conditions of the cleaning liquid containing AES after the first and second rinsing, respectively, and B1 is the foam condition of the cleaning liquid containing LA after the first rinsing.

[0093] Figure 5 1 is a comparison chart of the effects of using the dry shampoo of Example 10 and commercially available shampoo, wherein a1-a3 are the effects of using the dry shampoo of Example 10, a1 is before washing, a2 is after washing and naturally drying, and a3 is an enlarged view after washing; b1-b3 are the effects of using commercially available shampoo, b1 is before washing, b2 is after washing and naturally drying, and b3 is the effect chart after washing and naturally drying, and then continuing to wet the hair with a small amount of water and rubbing it. DETAILED DESCRIPTION

[0094] In one embodiment, a composition for cleaning or refreshing hair or scalp is provided, which comprises (a) a primary surfactant, (b) a co-surfactant, and (c) water.

[0095] The so-called primary surfactant refers to the surfactant with the highest content among all surfactants in terms of weight percentage. Further, the weight percentage of the primary surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; for example, exceeds 55wt%, 60wt%, 65wt%, 70wt%, 75wt%, 80wt%, 85wt%, 90wt%, 95wt%. In some examples, the content of the primary surfactant can reach 100%, that is, no co-surfactant is used at all.

[0096] For component (a), the main surfactant is composed of N-long-chain acyl amino acids and basic amino acids. Those skilled in the art will understand that there is no essential difference whether the N-long-chain acyl amino acids and basic amino acids are added to the composition independently, or the basic amino acid salts of the N-long-chain acyl amino acids are reacted first and then added to the composition, and are also covered by the scope of "composed of N-long-chain acyl amino acids and basic amino acids".

[0097] The weight percentage of N-long-chain acylamino acid in the composition is 1-12wt%, preferably 2-10wt%, 4-8wt%, more preferably 5-7wt%, most preferably 6-7wt%; for example, it can be 2wt%, 3wt%, 4wt%, 5wt% or more, 11wt%, 10wt%, 9wt%, 8wt%, 7wt% or less.

[0098] If the content of N-long chain acyl amino acid is greater than 12wt%, the composition will gradually feel sticky, and if the content of N-long chain acyl amino acid is less than 1wt%, the cleaning power is insufficient. From the perspective of taking into account both cleaning power and washing feeling, the most suitable content of N-long chain acyl amino acid is 5-7wt%.

[0099] The weight percentage of the basic amino acid in the composition is 0.5-8wt%, preferably 1-6.5wt%, 2-5.5wt%, more preferably 3-5wt%; for example, it can be 1wt%, 1.5wt%, 2wt%, 2.5wt% or more, and 7wt%, 6wt%, 5wt%, 4wt% or less.

[0100] The N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated straight-chain or branched fatty acid having 8 to 22 carbon atoms. Further, the N-long-chain acyl group in the N-long-chain acyl amino acid is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl.

[0101] The amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, and lysine. Further, the amino acids in the N-long-chain acyl amino acids are derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, and (methyl) taurine, preferably alanine, and most preferably L-alanine.

[0102] The N-long-chain acyl (methyl) taurine described in the present invention refers to N-long-chain acyl methyl taurine or N-long-chain acyl taurine.

[0103] As an example, the N-long-chain acyl amino acid can be selected from cocoyl alanine, lauroyl alanine, cocoyl sarcosine, lauroyl sarcosine, lauroyl glutamic acid, cocoyl glutamic acid, oleoyl glutamic acid, cocoyl glycine, lauroyl glycine, stearoyl glutamic acid, etc., preferably lauroyl alanine and lauroyl sarcosine, and especially preferably N-lauroyl-L-alanine.

[0104] The synthesis process of N-long-chain acylamino acids can refer to the general synthesis method of N-acylamino acid type surfactants, which can be divided into direct method and indirect method. The direct synthesis method of fatty acid raw materials includes enzyme catalytic synthesis and dehydration condensation. The indirect synthesis method includes fatty acid chloride acylation, fatty nitrile hydrolysis acylation, fatty acid anhydride acylation, amide carbonylation reaction, etc. More preferably, it is prepared by the reaction of fatty acid chloride with the amino group of amino acid (Shotten-Baumann condensation reaction or Shotten-Baumann reaction).

[0105] A typical preparation process suitable for the present invention is as follows: amino acid and sodium hydroxide are dissolved in water or a mixed solution of water and acetone to obtain an amino acid salt solution; then lauroyl chloride and sodium hydroxide solution are slowly added dropwise to the amino acid salt solution to control the pH of the reaction system, and after the addition is completed, the product is post-treated. Representative methods are disclosed in CN1798821A, US6703517B2, CN102875409B, JPH0570418A, etc.

[0106] For the post-treatment of the N-long-chain acyl amino acid product, conventional recrystallization, water washing, drying, etc. can be used, or the methods disclosed in CN202210867760.7 and PCT / CN2022 / 107270 can be used. Here, the relevant contents are introduced together.

[0107] The basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, and diaminopropionic acid, preferably arginine and / or lysine, and most preferably arginine.

[0108] For component (a), the main surfactant can also be composed of N-long chain acyl amino acid, N-long chain acyl amino acid dipeptide and basic amino acid. The introduction of N-long chain acyl amino acid dipeptide can further improve the comprehensive performance of the composition.

[0109] The types and synthesis methods of N-long-chain acyl amino acids and basic amino acids have been described above. N-long-chain acyl amino acid dipeptide is a known concept, and long-chain acyl amino acid dipeptide refers to long-chain acylaminoacyl amino acids, typically long-chain acyl glycyl glycine, long-chain acyl glutamyl glutamic acid, long-chain acyl alanyl alanine, long-chain acyl sarcosyl sarcosine, etc., for example, see CN100448968C, PCT / CN2022 / 107270, etc.

[0110] N-long-chain acyl amino acid dipeptide can be prepared from acyl chloride derived from N-long-chain acyl amino acid and amino acid by Schotten-Bowman reaction, etc.; or by reacting amino acid dipeptide such as glutamylglutamic acid with acyl chloride. Preferably, it is obtained by the relevant preparation method disclosed in PCT / CN2022 / 107270, and the relevant content is introduced here.

[0111] The N-long-chain acyl group in the N-long-chain acyl amino acid dipeptide is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, and palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl;

[0112] The amino acid in the N-long-chain acyl amino acid dipeptide is derived from one or more of alanine, glycine, glutamic acid, sarcosine, arginine, lysine, (methyl) taurine, preferably L-alanine. The present invention preferably uses N-long-chain acyl-L-alanine dipeptide, especially N-lauroyl-L-alanyl-L-alanine.

[0113] The weight percentage of N-long chain acyl amino acid and N-long chain acyl amino acid dipeptide in the composition is 1-12wt%, preferably 2-10wt%, 4-8wt%, more preferably 5-7wt%; for example, it can be 2wt%, 3wt%, 4wt%, 5wt% or more, 11wt%, 10wt%, 9wt%, 8wt%, 7wt% or less. The weight percentage of basic amino acid in the composition is 0.5-8wt%, preferably 1-6.5wt%, 2-5.5wt%, more preferably 3-5wt%; for example, it can be 1wt%, 1.5wt%, 2wt%, 2.5wt% or more, 7wt%, 6wt%, 5wt%, 4wt% or less.

[0114] Furthermore, the weight percentage of the N-long-chain acyl amino acid dipeptide in the composition is above 0.1 wt %, preferably above 0.3 wt %, and more preferably above 0.5 wt %.

[0115] Further, the weight ratio of N-long chain acyl amino acid to N-long chain acyl amino acid dipeptide is 20: 1 to 1.5: 1, preferably 15: 1 to 3: 1, more preferably 10: 1 to 6: 1. The weight ratio of N-long chain acyl amino acid to N-long chain acyl amino acid dipeptide is, for example, 20, 19, 18, 17, 16, 15, 14, 13, 12, 11, 10, 9, 8, 7, 6, 5, 4, 3.

[0116] For component (b), the co-surfactant comprises one or more of a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a sodium salt, a potassium salt, or a TEA salt of an N-long chain acylamino acid.

[0117] The weight percentage of the co-surfactant in the composition is 0-10wt%, for example, 0wt%, 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%; preferably 0-5wt%, more preferably 0-1wt%. It is not advisable to add too much co-surfactant, preferably add less or no co-surfactant, otherwise it will affect the mildness of the product to the skin / eyes, washing feeling, rinsing performance, etc.

[0118] Examples of nonionic surfactants include ester-type surfactants such as fatty acid glycerides, sorbitan fatty acid esters, and sucrose fatty acid esters, ether-type surfactants such as alkyl polyethylene glycols and polyoxyethylene alkylphenyl ethers, and nonionic surfactants such as alkyl polyglycosides. Nonionic surfactants have good emulsifying and solubilizing effects.

[0119] Examples of the cationic surfactant include alkyl quaternary ammonium salts, ester quaternary ammonium salts, alkyl pyridinium salts, alkyl amine salts and polymeric cationic surfactants. Cationic surfactants are often used in shampoos to increase the softness of hair.

[0120] As amphoteric surfactants, there can be cited: sulfobetaine amphoteric surfactants, betaine amphoteric surfactants, amphoteric acetate amphoteric surfactants, etc. For example, the amphoteric surfactant can be selected from one or more of cocamidopropyl betaine, lauroamidopropyl betaine, disodium cocoamphodiacetate, sodium cocamidoamphoacetate, sodium lauroamphoacetate, cocoyl betaine, lauryl hydroxysulfobetaine and lauroamidopropyl hydroxysulfobetaine. Amphoteric surfactants have good foaming, foam stabilizing and thickening effects.

[0121] The composition of the present invention can be substantially free of nonionic surfactants, cationic surfactants, and amphoteric surfactants by selecting specific main surfactants, especially a combination of N-long-chain acyl amino acids (which may also contain dipeptides) and basic amino acids, and preferably completely free of nonionic surfactants, cationic surfactants, and amphoteric surfactants, so that the product can be made to have a more refreshing washing feeling, easy rinsing, and low irritation. This compounding method breaks the existing formula theory and achieves unexpected effects of refreshing washing feeling, easy rinsing, low irritation, and selective decontamination.

[0122] When N-long-chain acyl amino acids (optionally dipeptides) and basic amino acids are selected as the main surfactants, the sodium salts, potassium salts, and TEA salts of the corresponding N-long-chain acyl amino acids can be used as co-surfactants (wherein the concept of N-long-chain acyl amino acids is as described above), which can take into account both performance and cost considerations. However, if cost is not considered, the surfactant is completely composed of N-long-chain acyl amino acids (which may also contain dipeptides) and basic amino acids without using any co-surfactants, which is the most preferred embodiment of the present invention.

[0123] Component (c) is not particularly limited. Specifically, ion exchange water, distilled water, purified water, river water, well water, natural water, groundwater, city water, hard water, soft water, etc. can be used. One of these can be used, or two or more selected from the above group can be mixed and used. From the viewpoint of storage stability and sanitation of the product of the present invention, ion exchange water, distilled water, purified water are preferred.

[0124] The composition may further comprise component (d) a preservative. The present invention unexpectedly found that benzoic acid has very good preservative properties in the system of the present invention, and its irritation is lower than other preservatives such as sodium benzoate, so the preservative is particularly preferably benzoic acid. Generally speaking, sodium benzoate is often used in cosmetics because it has better water solubility, and in the system of the present invention, the combination of basic amino acids and N-long-chain acyl amino acids (optionally dipeptides) can unexpectedly solubilize benzoic acid, making the use of benzoic acid in the system possible.

[0125] The composition may further comprise component (e) spices or flavors. The present invention particularly prefers spices or flavors with good water solubility. When the primary surfactant is a combination of N-long-chain acyl amino acids (optionally dipeptides) and basic amino acids, it is found that compared with the sodium salt and potassium salt of N-long-chain acyl amino acids, it has a more prominent solubilization effect on spices or flavors, and the solution is more likely to be clear and transparent, which is particularly important when the composition does not contain polyols.

[0126] In addition, the composition of the present invention may optionally further comprise other ingredients, such as dyes, chelating agents, extracts, amino acids, nucleic acids, vitamins, enzymes, anti-inflammatory agents, bactericides, antioxidants, ultraviolet absorbers, antiperspirants, pH regulators, pearlescent agents, etc., but the other ingredients cannot conflict with the safety and environmental protection, low irritation (skin / eye), easy rinsing, refreshing feeling, oil control, etc. pursued by the present invention.

[0127] Thickener: Existing cleaning products often add thickeners to obtain liquids with a certain viscosity. Commonly used thickeners include cellulose, mucopolysaccharides, polyvinyl alcohols, colloids, sodium polyacrylates, polyvinyl pyrrolidones, vinyl polymers and other thickeners, such as common types of starch, gelatin, sodium alginate, guar gum, chitosan, gum arabic, xanthan gum, soy protein glue, polyacrylamide, polyvinyl alcohol, polyvinyl pyrrolidone, modified paraffin resin, carbo resin, styrene-butadiene rubber, etc. However, the addition of these thickeners will increase the skin irritation and eye irritation of the product, and destroy the refreshing washing feeling of the product. Sodium chloride is also commonly used for thickening, but more sodium chloride will irritate the scalp and eyes. Therefore, the composition of the present invention is preferably substantially free of thickeners and sodium chloride, and more preferably completely free of thickeners and sodium chloride.

[0128] Sulfate surfactants: sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), sodium laureth sulfate (SLES) or ammonium laureth sulfate (ALES) may be mentioned. Considering that they may cause irritation to the skin or scalp and / or damage to hair fibers, the composition of the present invention is preferably substantially free of sulfate surfactants, more preferably completely free of sulfate surfactants.

[0129] Ethoxylate: A typical example is sodium laureth sulfate (SLES or AES). Considering that it is moderately irritating and that ethoxylated surfactants contain a large amount of non-renewable carbon from ethylene oxide, as well as safety issues (the dioxane impurities contained are carcinogenic), the composition of the present invention is preferably substantially free of ethoxylates, and more preferably completely free of ethoxylates.

[0130] Fatty acid salts: laurate, myristate, palmitate, stearate are mentioned. Considering the tension, dryness and tightness after washing caused by such raw materials, the composition of the present invention preferably does not contain substantially any fatty acid salt, and more preferably does not contain any fatty acid salt at all.

[0131] Polyol moisturizers: Examples include glycerols such as glycerol, diglycerol, and polyglycerol, sugar alcohols such as sorbitol, erythritol, and xylitol, and glycols such as isopentyl glycol, 1,2-propylene glycol (PG), dipropylene glycol (DPG), ethoxydiglycol, and 1,3-butylene glycol (BG). The addition of polyols will bring a heavier sticky feeling. The composition of the present invention preferably does not contain polyol moisturizers, and more preferably does not contain polyol moisturizers at all. Usually, cleaning products require the use of polyol moisturizers, but the present invention uses N-long-chain acyl amino acids (optional dipeptides) and basic amino acids as the main surfactants, which unexpectedly solves the problems of moisturizing and solubilization while exerting the cleaning effect.

[0132] In one embodiment, a method for reducing skin irritation or eye irritation in a composition is provided, wherein the composition comprises (a) a primary surfactant, (b) a co-surfactant, (c) water, and optionally other ingredients. Components (a), (b), (c), and optionally other ingredients are described in other embodiments and will not be repeated here.

[0133] The method for reducing skin irritation or eye irritation comprises: selecting a main surfactant to be composed of N-long chain acyl amino acid and basic amino acid; preferably, the weight percentage of N-long chain acyl amino acid in the composition is 1 to 12 wt%, preferably 4 to 8 wt%, more preferably 5 to 7 wt%, and the weight percentage of basic amino acid in the composition is 0.5 to 8 wt%, preferably 2 to 5.5 wt%, more preferably 3 to 5 wt%;

[0134] Alternatively, the main surfactant is selected to be composed of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid; preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide in the composition is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the composition is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%.

[0135] From the perspective of reducing irritation, it is preferred that substantially no thickener is added to the composition, preferably no thickener is added at all; and / or substantially no sulfate is added, preferably no sulfate is added at all; and / or substantially no ethoxylate is added, preferably no ethoxylate is added at all; and / or substantially no fatty acid salt is added, preferably no fatty acid salt is added at all; and / or substantially no polyol moisturizer is added, preferably no polyol moisturizer is added at all.

[0136] The preservative benzoic acid has lower irritation than sodium benzoate, and the N-long-chain acylamino acid-arginine system can solubilize benzoic acid to solve its solubility problem. Therefore, in order to reduce skin irritation or eye irritation, benzoic acid is preferably used as the preservative in the composition.

[0137] Weak acidity belongs to the pH range that is more suitable for the human body. Therefore, in order to reduce skin irritation or eye irritation, the pH of the composition is preferably 5.5-6.9, more preferably 6-6.7. Exemplarily, the suitable pH can be 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9.

[0138] Furthermore, the composition substantially does not contain nonionic surfactants, cationic surfactants, and amphoteric surfactants. Furthermore, the weight percentage of the co-surfactant in the composition is 0 wt%.

[0139] Further, the N-long-chain acyl amino acid is lauroyl alanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroyl alanyl alanine. That is, the primary surfactant is selected to be composed of N-long-chain acyl amino acids and basic amino acids, wherein the N-long-chain acyl amino acid is lauroyl alanine and the basic amino acid is arginine; or, the primary surfactant is selected to be composed of N-long-chain acyl amino acids, N-long-chain acyl amino acid dipeptide and basic amino acids, wherein the N-long-chain acyl amino acid is lauroyl alanine, the N-long-chain acyl amino acid dipeptide is lauroyl alanyl alanine, and the basic amino acid is arginine.

[0140] In one embodiment, a method for improving easy-rinsing performance or water-saving performance in a composition is provided, wherein the composition comprises (a) a primary surfactant, (b) a co-surfactant, (c) water, and optionally other ingredients. Components (a), (b), (c), and optionally other ingredients are described in other embodiments and will not be repeated here.

[0141] "Easy-rinsing performance" and "water-saving performance" refer to the fact that when using shampoo, facial cleanser, facial mousse, shower gel and other products, they can be rinsed quickly with water, leaving a refreshing feeling after washing, not sticky, and using less water for rinsing. Literature reports that the mechanism by which surfactants exert their easy-rinsing characteristics is that during the rinsing process, they combine with cations such as calcium ions to form precipitates or are not easy to form micelles in water, resulting in a very low content of surfactants adsorbed on the skin during rinsing, resulting in easy rinsing. On the contrary, if the surfactants are not combined with cations or are present in the system as micelles, more anionic surfactants will be adsorbed on the skin during rinsing, which is reflected in the slippery skin feel during rinsing, causing consumers to have the "illusion" that the product is not rinsed clean during use, thereby prolonging the rinsing time and consuming more water.

[0142] By selecting a specific main surfactant and controlling the amount of the main surfactant, the easy-rinsing performance or water-saving performance can be improved. The method for improving the easy-rinsing performance or water-saving performance comprises: selecting the main surfactant to be composed of N-long-chain acyl amino acids and basic amino acids; preferably, the weight percentage of the N-long-chain acyl amino acids in the composition is 1 to 12 wt%, preferably 4 to 8 wt%, more preferably 5 to 7 wt%, and the weight percentage of the basic amino acids in the shampoo is 0.5 to 8 wt%, preferably 2 to 5.5 wt%, more preferably 3 to 5 wt%;

[0143] Alternatively, the main surfactant is selected to be composed of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid; preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide in the composition is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the shampoo is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%.

[0144] For N-long-chain acyl amino acids / salts, when the amount of N-long-chain acyl glutamate is large, its foaming property is not satisfactory, and it imparts a sticky feeling, resulting in low rinsing properties. N-long-chain acyl glycinate has a more refreshing wash feeling than N-long-chain acyl glutamate, but N-long-chain acyl glycinate is easily precipitated in a weakly acidic to neutral system, resulting in an unstable system. The residue of N-long-chain acyl methyl taurine has a certain stickiness. Therefore, from the perspective of improving easy-to-rinse performance or water-saving performance, N-long-chain acyl amino acids are particularly preferably lauroyl alanine, because they have a very good wash feeling, are not sticky, and are stable under weakly acidic conditions.

[0145] For basic amino acids, especially arginine, they have a certain chelating effect on calcium and magnesium ions in water. When basic amino acids are combined with N-long-chain acyl amino acids as the main surfactant, the easy-to-rinse performance can be improved.

[0146] Most preferably, the main surfactant is selected to consist of lauroyl alanine and arginine, or the main surfactant is selected to consist of lauroyl alanine, lauroyl alanyl alanine and arginine.

[0147] In addition, from the perspective of improving the easy-to-rinse performance or water-saving performance, it is preferred that substantially no thickener is added to the composition, preferably no thickener is added at all; and / or substantially no sulfate is added, preferably no sulfate is added at all; and / or substantially no ethoxylate is added, preferably no ethoxylate is added at all; and / or substantially no fatty acid salt is added, preferably no fatty acid salt is added at all; and / or substantially no polyol moisturizer is added, preferably no polyol moisturizer is added at all.

[0148] Furthermore, the composition substantially does not contain nonionic surfactants, cationic surfactants, and amphoteric surfactants. Furthermore, the weight percentage of the co-surfactant in the composition is 0 wt%.

[0149] In one embodiment, a composition with excellent deodorizing performance is provided, which comprises (a) a primary surfactant, (b) a co-surfactant, (c) water and optionally other ingredients. Components (a), (b), (c) and optionally other ingredients refer to the relevant descriptions in other embodiments. At the same time, the present invention also provides a method for improving the deodorizing performance in a composition.

[0150] The method for improving the deodorizing performance comprises: selecting a primary surfactant to be composed of an N-long-chain acyl amino acid and a basic amino acid, wherein the basic amino acid is present in an amount that partially neutralizes the N-long-chain acyl amino acid, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and less than 96%;

[0151] Alternatively, the main surfactant is selected to be composed of N-long-chain acyl amino acids, N-long-chain acyl amino acid dipeptides and basic amino acids, and the basic amino acids are present in an amount to partially neutralize the N-long-chain acyl amino acids and N-long-chain acyl amino acid dipeptides, preferably with a neutralization degree of more than 85% and less than 100%, and more preferably with a neutralization degree of more than 88% and less than 96%.

[0152] In a preferred embodiment, the degree of neutralization is above 85%, for example, the degree of neutralization is 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%. Further, from the perspective of molar ratio, the molar ratio of N-long chain acyl amino acid (optional dipeptide) to basic amino acid / inorganic base is 1:0.98 to 1:0.85, preferably 1:0.96 to 1:0.88, more preferably 1:0.95 to 1:0.90. Exemplarily, when the N-long chain acyl amino acid is 1 mol, the basic amino acid is 0.98, 0.97, 0.96, 0.95, 0.94, 0.93, 0.92, 0.91, 0.90, 0.89, 0.88, 0.87, 0.86 or 0.85 mol.

[0153] The present invention surprisingly found that when the degree of neutralization is above 85% and less than 100%, the composition system contains a small amount of unneutralized N-long-chain acyl amino acid and / or N-long-chain acyl amino acid dipeptide, which has a very good effect on removing odor.

[0154] Lauroyl alanine molecules are easy to self-assemble to form a supramolecular structure, which is beneficial to the adsorption and removal of odor molecules. Therefore, it is most preferred that the N-long-chain acyl amino acid is lauroyl alanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroyl alanyl alanine.

[0155] In one embodiment, a method for imparting oil control properties to a composition is provided, the composition comprising (a) a primary surfactant, (b) a co-surfactant, (c) water and optionally other ingredients. Components (a), (b), (c) and optionally other ingredients refer to the relevant descriptions in other embodiments, which will not be repeated here.

[0156] The method for imparting oil control properties to a composition comprises: selecting a primary surfactant to be composed of an N-long chain acyl amino acid and a basic amino acid;

[0157] Alternatively, the primary surfactant is selected to consist of an N-long chain acyl amino acid, an N-long chain acyl amino acid dipeptide and a basic amino acid.

[0158] The present invention first discovered that the combination of N-long chain acyl amino acid (optionally dipeptide) and basic amino acid has good oil control performance.

[0159] Most preferably, the N-long-chain acyl amino acid is lauroylalanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroylalanylalanine.

[0160] In the above embodiments, the composition of the present invention can be further controlled to be weakly acidic to weakly alkaline, preferably weakly acidic, that is, the pH of the composition is 5-7.5, preferably 5.5-6.9, more preferably 6-6.7. Exemplarily, the suitable pH can be 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6.0, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5.

[0161] In each of the above embodiments, the composition of the present invention is further low-viscosity. The low viscosity means that the viscosity at 25°C is less than 150 mPa·s, preferably less than 120 mPa·s, and more preferably less than 100 mPa·s. The lower limit of the viscosity is not particularly limited, and 1 mPa·s or more can be cited. The viscosity can be measured by conventional methods, for example, the composition at 25°C can be measured using a B-type viscometer.

[0162] In each of the above embodiments, the composition of the present invention further exhibits a selective decontamination performance, that is, according to QB / T1224-2012 liquid detergent for clothing, JB-01 and JB-02 have higher values, while JB-03 has a lower value. Further, JB-01 is above 0.8, preferably above 0.81, 0.82, 0.83, 0.84, 0.85, 0.86, 0.87, 0.88, 0.89 or 0.9; JB-02 is above 0.8, preferably above 0.81, 0.82, 0.83, 0.84, 0.85, 0.86, 0.87, 0.88, 0.89 or 0.9; JB-03 is above 0.4 The molecular weight of the present invention is 0.54, 0.62, 0.64, 0.66, 0.67, 0.68, 0.69, 0.70, 0.71, 0.72, 0.73, 0.74, 0.76, 0.77, 0.78, 0.79, 0.71, 0.70, 0.71, 0.71, 0.72, 0.73, 0.74, 0.76, 0.77, 0.78, 0.79, 0.71, 0.72, 0.71, 0.70, 0.71, 0.72, 0.73, 0.74, 0.76, 0.76, 0.77, 0.78, 0.79, 0.71, 0.72, 0.71, 0.70 ...

[0163] Compared with traditional petroleum-based surfactants such as AES, which show too high human skin oil cleaning (JB-03 reaches 1.4), it will damage the skin's protective barrier, causing excessive loss of sebum, and easy invasion or stimulation of harmful substances, resulting in dryness, tightness, stinging, and even skin sensitivity after washing. The composition of the present invention (especially the combination of N-long-chain acyl amino acids and basic amino acids) can not only selectively remove dirt, but also will not excessively wash away "squalene" and triglycerides that protect the skin, protecting the skin's moisture barrier (JB-01 and JB-02 exceed 0.8 or even 0.9, but JB-03 maintains around 0.5).

[0164] In the above embodiments, the composition of the present invention further exhibits unexpectedly excellent hard water resistance. Further, according to the test standard: GB / T7462-1994 "Determination of foaming power of surfactants-Improved Ross-Miles method", the test instrument: 2152 improved Ross foam instrument, the foam performance of the composition in hard water is better than that in soft water. Preferably, under hard water conditions, the foam volume of 30s, 3min, and 5min is more than 400ml.

[0165] Most preferably, the main surfactant is selected to be composed of lauroyl alanine (optional dipeptide) and arginine, the weight percentage of lauroyl alanine in the composition is 1-12wt%, preferably 4-8wt%, more preferably 5-7wt%, and the weight percentage of basic amino acid in the shampoo is 0.5-8wt%, preferably 2-5.5wt%, more preferably 3-5wt%. At this time, under hard water conditions, the foam volume of 30s, 3min, and 5min exceeds 450ml, more preferably exceeds 460, 470, 480, 490 or 500ml.

[0166] The composition of the present invention can be used to prepare a wash-free cleaning product or a dry cleaning product. The "wash-free cleaning product" and "dry cleaning product" refer to cleaning products that can be used to remove dirt from the body, hair, etc. without washing with water, and can be wiped with a dry towel or a wet towel. Preferably, it can be used to prepare a wash-free or dry cleaning shampoo, a wash-free or dry cleaning agent for pets.

[0167] The composition of the present invention maintains low irritation while maintaining good cleaning power, and when arginine and N-long-chain acylamino acid are selected as the main surfactant, the product is also endowed with certain moisturizing properties. Therefore, it is very suitable for treating or cleaning delicate or dry, aged, and damaged skin. It is particularly suitable for making cleaning products for infants or the elderly, such as shampoos for infants or the elderly.

[0168] In each embodiment, if there is no conflict in the content, detailed circumstances, type selection, dosage selection, etc. that are not discussed, reference can be made to the relevant guidance of other embodiments. For the sake of brevity, each embodiment is not described one by one.

[0169] The term "substantially free" as used herein means that the content of the substance in the composition will not significantly or substantially affect the performance of the product. Further, "substantially free" means that the weight percentage of the substance in the composition is less than 0.5wt%, preferably less than 0.1wt% or less than 0.01wt%, and more preferably less than the detectable limit.

[0170] Unless otherwise specified, "above", "below" and "A to B" in the present invention all include the number. The dosage refers to the dosage of a specific substance, not the dosage of its corresponding solution (if any).

[0171] The combination of N-long-chain acyl amino acid (optional dipeptide) and basic amino acid described in the present invention means that the main surfactant consists of N-long-chain acyl amino acid and basic amino acid or the main surfactant consists of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid.

[0172] The present invention will be further described below in conjunction with the accompanying drawings and examples, and it should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalents also fall within the scope limited by the appended claims of the present application.

[0173] The present invention will be further described below with reference to specific embodiments.

[0174] Example 1 Skin irritation test .

[0175] Test basis: Human skin irritation: Reconstructed human epidermis test method OECD TG 439 (2021).

[0176] Table 1

[0177]

[0178] 1. The negative control is DPBS solution.

[0179] 2. The positive control is 5% SDS.

[0180] 3. The salt prepared by reacting lauroyl alanine with sodium hydroxide in a molar ratio of 1:1.

[0181] 4. The salt prepared by reacting lauroyl alanine with arginine in a molar ratio of 1:1.

[0182] According to the data in Table 1, it can be found that surfactants based on N-long-chain acyl amino acids (lauroyl alanine) have significantly reduced skin irritation, especially the combination of lauroyl alanine and arginine, which has almost no irritation to the human epidermis.

[0183] However, traditional surfactants such as AES and K12 are obviously more irritating, and their addition will have an adverse effect on the mildness and low irritation of the end product.

[0184] Example 2 Eye irritation test .

[0185] Test basis: Bovine corneal opacity and permeability test OECD TG 437 (2020).

[0186] Table 2

[0187]

[0188] 1. It is composed of lauroyl alanine, sodium hydroxide and water, and the composition contains 10% lauroyl alanine sodium salt.

[0189] 2. It is composed of lauroyl alanine, arginine and water, and the composition contains 10% lauroyl alanine arginine salt.

[0190] 3. Take 1g AES (70% content), add water to make up to 10ml, and dilute to 10% (W / V).

[0191] 4. Take 1g K12, add water to make up to 10ml, and dilute to 10% (W / V).

[0192] According to the data in Table 2, it can be found that the surfactants compounded with N-long-chain acyl amino acids and basic amino acids (compounded with lauroyl alanine and arginine) have the lowest irritation to the eyes. However, traditional surfactants such as AES and K12 and the sodium salt of N-long-chain acyl amino acids (sodium salt of lauroyl alanine) are relatively irritating to the eyes.

[0193] Example 3 Cleaning power test .

[0194] Test basis: QB / T 1224-2012 Test for liquid detergents for clothing. The following contents refer to percentage by weight.

[0195] JB-01 involves artificial simulation of mixed oil stains, mainly verifying the cleaning power against oil and dust stains; JB-02 involves multiple protein stains, mainly verifying the cleaning power against protein stains; JB-03 involves artificial simulation of sebum stains, mainly verifying the cleaning power against human body oil stains.

[0196] Table 3

[0197]

[0198] According to the data in Table 3, it can be found that whether lauroyl alanine is compounded with an inorganic base (sodium hydroxide in the embodiment) or with a basic amino acid (arginine in the embodiment), the values ​​of JB-01 and JB-02 are both high, indicating that the removal ability of oil, dust stains, and protein stains is strong, and the value of JB-03 is moderate, indicating that the removal ability of human sebum stains is moderate, reflecting obvious selective decontamination ability. This is crucial to not excessively wash away the "squalene" and triglycerides that protect the skin and protect the skin's moisture barrier.

[0199] In addition, the data also show that lauroyl alanine-arginine-based surfactants have excellent cleaning power for oil, dust stains, and protein stains, which is significantly stronger than common mild surfactants such as glutamate and sophorolipids, making it possible to use lauroyl alanine-arginine as the main surfactant.

[0200] Example 4 Makeup removal test .

[0201] Test reagents: ① sodium lauroyl glutamate aqueous solution, ② potassium cocoyl glycinate aqueous solution, ③ sodium lauroyl sarcosinate aqueous solution, ④ lauroyl alanine arginine aqueous solution.

[0202] Test plan: Prepare a standard aqueous solution by mixing 4 commercially available amino acid surfactant solutions with water at a ratio of 1:20. Weigh 2g of each sample and apply it to the skin that has been smeared with lipstick. After wetting, wipe with hands to observe the makeup removal ability.

[0203] The solid content of commercially available sodium lauroyl glutamate solution, potassium cocoyl glycinate solution, and sodium lauroyl sarcosinate solution is about 30%-35%. The lauroyl alanine arginine solution is LA-Arg 30 (containing 20% ​​lauroyl alanine + 12.8% arginine) produced by Suzhou Weimei Biotechnology Co., Ltd.

[0204] Figure 1 and Figure 2 The figure shows the effect of removing lipstick by wiping with hands after wetting. As can be seen from the figure, the makeup removal ability from strong to weak is: ④ lauroyl alanine arginine aqueous solution > ② cocoyl glycinate potassium aqueous solution > ③ lauroyl sarcosinate sodium aqueous solution > ① lauroyl glutamate sodium aqueous solution.

[0205] From this test, it can be seen that the surfactant based on lauroyl alanine-arginine has a higher cleaning power than the traditional amino acid surfactant. Combined with Examples 3 and 4, it is verified for the first time that the lauroyl alanine-arginine compound can be used as the main surfactant.

[0206] Example 5 Foam test .

[0207] Test standard: GB / T7462-1994 "Determination of foaming power of surfactants - Improved Ross-Miles method".

[0208] Test instrument: Model 2152 Improved Roche Foam Tester.

[0209] Test method: According to the test standard GB / T7462-1994, test the foaming power of the samples and compare the differences in their foam performance.

[0210] Test conditions: Test solution concentration: 2.5g / L; Test temperature: 50±0.5℃; Test water: soft water / hard water.

[0211] Reagents: DCG30: Sodium Cocoyl Glutamate, ACS30: Sodium Cocoyl Alanine, GC30: Sodium Cocoyl Glycinate, GCK30: Potassium Cocoyl Glycinate, SCMT-35: Sodium Cocoyl Methyl Taurate, AES: Sodium Laureth Sulfate.

[0212] Table 4

[0213]

[0214]

[0215] The test results are shown in Table 4 and Figure 3 It can be seen that lauroyl alanine-arginine has better foaming performance in hard water than in soft water, indicating that it has the property of resisting hard water. Considering that most areas in China have hard water, lauroyl alanine-arginine is very suitable as the main surfactant of shampoo. Under hard water conditions, its foaming performance is even better than AES.

[0216] Example 6 Deodorizing performance .

[0217] Test equipment: drum washing machine (XQB80-Z1708), electronic balance (PL2002), pipette (5mL).

[0218] Test materials and reagents:

[0219] JB-00 cotton white cloth (GB / T 13174, 25cm25cm); artificial sweat (QB / T1901.2-93); pure cotton T-shirt; yellow croaker.

[0220] Test process

[0221] Fishy odor removal test: Put the chilled yellow croaker into a sealed bag and add 30mL of tap water, and leave it at room temperature for 4 hours. Find 5 testers and wash their hands with clean water to ensure that there is no odor. Take the water in the sealed bag and drop 5mL in the palm of each tester. The tester evenly applies the fishy odor water to the backs and palms of both hands, waits for 5 minutes, takes 2mL of the sample solution to be tested, simulates washing hands with hand sanitizer for 2 minutes, rinses with tap water and wipes the water off the hands, and the tester feels whether there is still odor on the hands.

[0222] Sweat odor removal test: Take a piece of JB-00 cotton white cloth, evenly add 2mL of artificial sweat, and then put it in a sealed bag for 4 hours. Select the common washing mode of the washing machine, select 30L of water, rinse twice, dehydrate for 5 minutes, put in 3 pure cotton T-shirts and sweat-stained cotton white cloth, add 60g of the sample solution to be tested, start the washing machine for washing, and take out the pure cotton T-shirts and cotton white cloth to dry after washing. Find 5 evaluation personnel to feel whether there is still odor on the cotton white cloth.

[0223] The results were evaluated according to the following criteria:

[0224] 0 points – no odor residue;

[0225] 1 point: slight odor remains;

[0226] 2 points: There is a noticeable odor residue.

[0227] Table 5

[0228]

[0229] 1# Lauroyl Sarcosinate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remainder Water (TO 100)

[0230] 2# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Essence 0.25% + Balance Water (TO 100)

[0231] 3# Lauroyl Alanine 6% + Arginine 3.45% + Benzoic Acid 0.2% + Essence 0.25% + Remaining Water (TO 100)

[0232] According to the evaluation data in Table 5, it can be known that when lauroyl alanine and basic amino acids are compounded in a molar ratio of 1:0.9, the best deodorizing performance is achieved.

[0233] Example 7 Easy rinse performance .

[0234] Test I

[0235] Test materials and reagents:

[0236] a) each sample solution to be tested;

[0237] b) Artificial dirt, prepared according to B2.4 of GB / T 9985-2000;

[0238] c) anhydrous calcium chloride, AR.;

[0239] d) Magnesium chloride (MgCl2·6H2O), AR.;

[0240] e) Deionized water.

[0241] Instruments and equipment:

[0242] a) Electronic balance, accuracy 0.01g;

[0243] b) 2 white porcelain dish plates, outer diameter about 250mm;

[0244] c) Washbasin, volume 6L;

[0245] d) Graduated cylinder, 1000 mL;

[0246] e) Bottom-mouth bottle (see GB / T 9985), 5000 mL;

[0247] f) Pig brown paint brush, 102mm.

[0248] Test process:

[0249] a) According to the operation of B2.5 of GB / T 9985-2000, prepare two plates coated with artificial dirt. The amount of dirt on each test plate is 4g. After coating, place them at room temperature overnight for use;

[0250] b) Wash the two test plates cleanly according to the washing procedure in B2.6 of GB / T 9985-2000 (using each sample solution as the test sample);

[0251] c) Pour 1000 mL of deionized water into the lower-mouthed bottle (the lower part of the outlet tube of the lower-mouthed bottle is pre-filled with deionized water and excess water is released until no more water can be released), open the outlet tube and rinse the dishes washed in step (b) with 1000 mL of deionized water, and collect the rinse liquid.

[0252] d) Repeat step (c) for each test disk to prepare the second rinse solution and the third rinse solution.

[0253] Results evaluation:

[0254] By testing the pH of the resulting rinse solution, the residual condition of the test sample can be determined, and the easy-rinsing performance of the product can be determined based on the result.

[0255] Table 6

[0256]

[0257]

[0258] 1# Lauroyl Sarcosinate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remainder Water (TO 100)

[0259] 2# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Alkyl Glucoside 1% + Cocamidopropyl Betaine 4.5% + Glycerin 5% + Essence 0.25% + Remainder Water (TO 100)

[0260] 3# Sodium Cocoyl Glutamate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remaining Water (TO 100)

[0261] 4# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Essence 0.25% + Balance Water (TO 100)

[0262] Test II

[0263] An aqueous solution containing 6% AES was prepared as cleaning solution A, and an aqueous solution containing 6% lauroyl alanine (neutralized with equimolar arginine) was prepared as cleaning solution B. The laundry process was simulated, and rinsing was performed and the rinsing solution was collected. The results are as follows: Figure 4 As shown. After the first rinse, the cleaning solution containing AES is stirred by a vibrator, and more foam will still appear ( Figure 4 A1), after the second rinse, stirred with a vibrator, basically no bubbles ( Figure 4 A2). However, the cleaning solution containing lauroyl alanine (LA) was stirred with a vibrator after the first rinse, and there was basically no foam ( Figure 4 B1).

[0264] Example 8 Washing feeling, irritation .

[0265] Find 5 reviewers to conduct the evaluation. Washing feeling (apply each sample to be tested directly to the arm / face, dry clean / no wash): non-sticky 0, slightly sticky 1, moderately sticky 2, and severely sticky 3.

[0266] Find 5 evaluators to conduct the evaluation. Irritation (apply each sample to be tested directly to the arm / face, dry clean / no wash): mild and non-irritating 0, mild irritation 1, moderate irritation 2, severe irritation 3.

[0267] Table 7

[0268]

[0269]

[0270] 1# Lauroyl Sarcosinate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remainder Water (TO 100)

[0271] 2# Lauroyl Alanine 6% + NaOH 0.87% + Benzoic Acid 0.4% + Essence 0.25% + Balance Water (TO 100)

[0272] 3# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Alkyl Glucoside 1% + Cocamidopropyl Betaine 4.5% + Glycerin 5% + Essence 0.25% + Remainder Water (TO 100)

[0273] 4# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Alkyl Glucoside 2% + Essence 0.25% + Balance Water (TO 100)

[0274] 5# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Cocamidopropyl Betaine 6% + Essence 0.25% + Balance Water (TO 100)

[0275] 6# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Glycerin 10% + Essence 0.25% + Remaining Water (TO 100)

[0276] 7# Sodium Cocoyl Glutamate 6% + Benzoic Acid 0.4% + Essence 0.25% + Remaining Water (TO 100)

[0277] 8# Lauroyl Alanine 6% + Arginine 3.84% + Benzoic Acid 0.2% + Essence 0.25% + Balance Water (TO 100)

[0278] Example 9 Cleansing solution patch test .

[0279] Table 8

[0280] raw material Dosage (W%) A water 89.71 B Lauroyl Alanine 6 C Arginine 3.84 D benzoic acid 0.2 E essence 0.25

[0281] Heat and dissolve raw materials A, B, and C at 80-85°C, and stir until they are completely dissolved and transparent; then cool to below 45°C, add D and E, and stir until they are completely dissolved and uniform; take samples, and filter out the material after passing the test.

[0282] A human skin patch test was conducted on the above cleaning solutions.

[0283] 1. Test basis: SOP502-01CL- Single human skin patch test

[0284] 2. Materials and Methods

[0285] 2.1 Test article: Test as is.

[0286] 2.2 Negative control: Use grade 3 water in GB / T 6682.

[0287] 2.3 Subjects: A total of 30 subjects, 4 males and 26 females, aged 22 to 54 years old.

[0288] 2.4 Method: Select qualified patch test equipment and use the closed patch test method. Place about 0.02 mL of the test substance in the patch tester and apply it to the upper back of the subject with a hypoallergenic tape. Remove the test substance after 48 hours and observe the skin reaction 30 minutes after removal. Record the results according to the skin reaction grading standard in the "Safety Technical Specifications for Cosmetics" (2015 edition).

[0289] 3. Subject inclusion criteria

[0290] 3.1 Select volunteers aged 18-60 who meet the test requirements as subjects.

[0291] 4. Test Results

[0292] Table 9

[0293]

[0294] Note: The skin reactions of 30 subjects to a single 48-hour patch are shown in Table 10.

[0295] The results of the 48-hour irritation patch test showed that in a single 48-hour patch test, 0 of the 30 people had adverse skin reactions, indicating that the cleaning solution of the present invention can be washed without water, and even if the cleaning solution stays on the skin for 48 hours, no adverse skin reactions will occur.

[0296] Table 10 Skin reactions of 30 subjects in a single human skin patch test

[0297]

[0298]

[0299]

[0300] Furthermore, a limit test was conducted, and the operation in Section 2.4 was repeated 3 times (i.e., 48 h × 3) according to SOP502-01CL-Multiple Human Skin Patch Test, and the results are recorded in Table 11. Among them, test substance 1 was obtained according to the formulation and preparation method of Table 8; test substance 2 was obtained according to the formulation and preparation method of Table 8, except that the preservative benzoic acid was replaced with sodium benzoate.

[0301] Table 11

[0302]

[0303] The results of the 48h×3 irritation patch test showed that since the preservative of Test 2 was replaced with sodium benzoate, the number of people with skin reactions reached 9 after 3 cycles of patch tests, which was nearly 1 times that of Test 1 using benzoic acid (the number of people with skin reactions was 5). This shows that the use of benzoic acid as a preservative has significantly reduced skin irritation.

[0304] Example 10 Dry Shampoo (Simple Formula) .

[0305] Table 12 Dry shampoo formula

[0306] raw material Dosage (W%) A water 89 B Lauroyl Alanine 6.6 C Arginine 4.2 D benzoic acid 0.2

[0307] Heat raw materials A, B, and C at 80-85°C to dissolve; then cool to below 45°C and add D.

[0308] Table 13: A commercially available shampoo formula

[0309] raw material Dosage (W%) 1 water To 100 2 Lauroyl Alanine 4 3 Arginine 2.6 4 Polyquaternium-10 0.7 5 Disodium EDTA 0.1 6 Cocamide Methyl MEA 5 7 TEA cocoyl glutamate (30%) 12 8 glycerin 5 9 Sodium lauroyl sarcosinate (30%) 12 10 Sodium Benzoate 0.4 11 Citric Acid 0.01 12 Sodium Citrate 0.01 13 Cocamidopropyl Betaine (30%) 3.5 14 Lauramidopropyl betaine (30% 3.5 15 Phenoxyethanol 0.8 16 (Daily Use) Fragrance 0.2 17 Polysorbate 20 0.5

[0310] Table 14 Performance evaluation

[0311] Example 10 Shampoo Commercial shampoo Combing good Parts of hair stuck together Refreshing feeling after washing good Feeling heavy Fluffiness after washing good Hair becomes stiff after dry cleaning

[0312] After washing with the dry shampoo in this embodiment, the hair feels very fresh, the hair is fluffy, and the combing property is also very good (see Figure 5 a1-a3). Even if lauroyl alanine-arginine is used in conventional shampoos on the market, it cannot be used as dry shampoo if it is not used as the main surfactant and the amount of other auxiliary surfactants added is not controlled. During the dry cleaning process, the hair is easily stuck together, just like using mousse to style the hair, making the user feel that the hair is heavy and not refreshing (see Figure 5 b1-b2). If you add a little water and rub it, a lot of foam will appear (see Figure 5 b3).

[0313] Embodiment 11 Oil Control .

[0314] 1Test Purpose

[0315] The secretion of oil in human skin is greatly affected by male hormones, which stimulate the sebaceous glands to secrete oil. 5α-reductase is the key enzyme in the metabolism of male hormones. Currently, the main oil control products on the market mostly use ingredients that can effectively inhibit 5α-reductase, improve oil secretion and achieve oil control effects.

[0316] 2 Test item: Test -5α-reductase inhibition rate.

[0317] 3 Test Materials

[0318] 3.1 Main reagents

[0319] 1) 5α-reductase: extracted from rat prostate tissue and stored at -80°C.

[0320] 2) Sample preparation (TA): lauroyl alanine 6% + arginine 3.84% + benzoic acid 0.2% + essence 0.25% + balance water (TO 100). The reaction concentration in the experimental system is 30% (V / V).

[0321] 3) Blank control (BC): phosphate buffered saline (PBS).

[0322] 3.2 Main equipment: High performance liquid chromatography (HPLC).

[0323] 4 Test Methods

[0324] 4.1 Preparation of 5α-reductase: Take it from the prostate of male rats. Use pre-cooled buffer to make a 1:5 homogenate in a glass homogenizer at 0℃, centrifuge at 3000g for 10min, take the supernatant and centrifuge at 10000g for 30min, take the supernatant and divide it into EP tubes, 1mL per tube, which is the enzyme extract, and store it in a -80℃ refrigerator.

[0325] 4.2 5α-reductase activity determination: The 2mL reaction system contains: 0.25mL phosphate buffer, 0.70mL enzyme extract, 0.1mL testosterone solution (0.5mg / mL), 0.35mL NADPH solution (1mg / mL), (10% ethanol in the complete reaction group, sample solution in the sample group) 0.6mL. The control tube replaced the enzyme extract with phosphate buffer, and added 2.0mL dichloromethane to terminate the reaction; the sample tube reacted at 37°C for 30min, and after the reaction, 2.0mL dichloromethane was added to stop the reaction, and the reaction was shaken for 1min and centrifuged at 5000r / min for 10min. Remove the upper aqueous phase, remove about 1.0mL of the organic phase and evaporate to dryness, dissolve the residue in 1.0mL methanol, and use high performance liquid chromatography to determine the testosterone peak area (T). Set up 3 parallel tubes for each reaction. Calculation of inhibition rate:

[0326]

[0327] 5Test results

[0328] The results of 5α-reductase activity inhibition rate are shown in Table 15.

[0329] Table 15 Summary of 5α-reductase activity inhibition rate results

[0330]

[0331] Note: When the t-test method is used for statistical analysis, the significance of the sample group compared with the complete response group is indicated by *, p-value < 0.05 is indicated by *, and p-value < 0.01 is indicated by **.

[0332] Compared with the NC group, the 5α-reductase inhibition rate of the sample at a system concentration of 30% (V / V) was 69.77%, which was statistically significant (p<0.01).

[0333] In addition, those skilled in the art will appreciate that, although some embodiments described herein include certain features included in other embodiments but not other features, the combination of features of different embodiments is meant to be within the scope of the present invention and form different embodiments. For example, in the claims below, any one of the claimed embodiments may be used in any combination.

Claims

1. A composition for cleaning or refreshing hair or scalp, characterized in that Comprising (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50wt%, preferably exceeds 65wt%, and more preferably exceeds 80wt%; The main surfactant is composed of N-long chain acyl amino acid and basic amino acid, preferably, the weight percentage of N-long chain acyl amino acid in the composition is 1-12wt%, and the weight percentage of basic amino acid in the composition is 0.5-8wt%; Alternatively, the main surfactant is composed of N-long-chain acyl amino acid, N-long-chain acyl amino acid dipeptide and basic amino acid, preferably, the total weight percentage of N-long-chain acyl amino acid and N-long-chain acyl amino acid dipeptide in the composition is 1-12wt%, and the weight percentage of basic amino acid in the composition is 0.5-8wt%; The weight percentage of the co-surfactant in the composition is 0-10wt%, preferably 0-5wt%, more preferably 0-1wt%.

2. The composition according to claim 1, characterized in that The composition is substantially free of thickeners, preferably completely free of thickeners; and / or, substantially free of sodium chloride, preferably completely free of sodium chloride; and / or, substantially free of sulfates, preferably completely free of sulfates; and / or, substantially free of ethoxylates, preferably completely free of ethoxylates; and / or, substantially free of fatty acid salts, preferably completely free of fatty acid salts; and / or, substantially free of polyol humectants, preferably completely free of polyol humectants.

3. The composition according to claim 1, characterized in that The N-long-chain acyl group in the N-long-chain acyl amino acid is derived from a saturated or unsaturated straight-chain or branched fatty acid having 8 to 22 carbon atoms; And / or, the amino acids in the N-long-chain acyl amino acids are derived from one or more of glycine, alanine, glutamic acid, sarcosine, aspartic acid, leucine, isoleucine, valine, threonine, proline, phenylalanine, arginine, lysine, and (methyl)taurine.

4. The composition according to claim 1, characterized in that The invention further comprises (d) a preservative, wherein the preservative is benzoic acid.

5. The composition according to claim 1, characterized in that The composition does not contain a cationic polymer; and / or, the composition does not contain a silicone oil.

6. The composition according to claim 1, characterized in that The pH of the composition is 5 to 7.5, preferably 5.5 to 6.9, more preferably 6 to 6.5; And / or, the composition has a low viscosity, wherein the low viscosity means that the viscosity at 25° C. is lower than 150 mPa·s, preferably lower than 120 mPa·s, more preferably lower than 100 mPa·s.

7. The composition according to claim 1, characterized in that The specified cloth detergency of the composition is tested in accordance with QB / T1224-2012 Liquid Detergents for Clothes, and is above 0.8 for JB-01; and / or above 0.8 for JB-02; and / or above 0.4 and below 0.8 for JB-03.

8. A no-rinse or dry-cleaning shampoo, characterized in that: A composition comprising any one of claims 1 to 7.

9. A cleaning agent for pets, characterized in that: A composition comprising any one of claims 1 to 7.

10. A shampoo for infants or the elderly, characterized in that: A composition comprising any one of claims 1 to 7.

11. A method for reducing scalp irritation or eye irritation in a shampoo, characterized in that: The shampoo comprises (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %; The method for reducing scalp irritation or eye irritation comprises: selecting a primary surfactant to be composed of N-long chain acyl amino acids and basic amino acids; Alternatively, the primary surfactant is selected to consist of an N-long chain acyl amino acid, an N-long chain acyl amino acid dipeptide and a basic amino acid.

12. The method for reducing scalp irritation or eye irritation in a shampoo according to claim 11, characterized in that: The shampoo contains substantially no thickener, preferably no thickener at all; and / or substantially no sodium chloride, preferably no sodium chloride; and / or substantially no sulfate, preferably no sulfate; and / or substantially no ethoxylate, preferably no ethoxylate; and / or substantially no fatty acid salt, preferably no fatty acid salt; and / or substantially no polyol moisturizer, preferably no polyol moisturizer.

13. The method for reducing scalp irritation or eye irritation in a shampoo according to claim 11, characterized in that: The preservative of choice in shampoo is benzoic acid.

14. The method for reducing skin irritation or eye irritation in a shampoo according to claim 11, characterized in that: The N-long-chain acyl amino acid is lauroylalanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroylalanylalanine.

15. A method for improving the easy-rinsing performance or water-saving performance in a shampoo, characterized in that: The shampoo comprises (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %; The method for improving easy-rinsing performance or water-saving performance comprises: selecting a main surfactant to be composed of N-long-chain acyl amino acids and basic amino acids; Alternatively, the primary surfactant is selected to consist of an N-long chain acyl amino acid, an N-long chain acyl amino acid dipeptide and a basic amino acid.

16. The method for improving the easy-rinsing performance or water-saving performance in shampoo according to claim 15, characterized in that: The shampoo contains substantially no thickener, preferably no thickener at all; and / or substantially no sodium chloride, preferably no sodium chloride; and / or substantially no sulfate, preferably no sulfate; and / or substantially no ethoxylate, preferably no ethoxylate; and / or substantially no fatty acid salt, preferably no fatty acid salt; and / or substantially no polyol moisturizer, preferably no polyol moisturizer.

17. The method for improving the easy-rinsing performance or water-saving performance in shampoo according to claim 15, characterized in that: The N-long-chain acyl amino acid is lauroylalanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroylalanylalanine.

18. A method for improving the deodorizing performance in a shampoo, characterized in that: The shampoo comprises (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %; The method for improving the deodorizing performance comprises: selecting a primary surfactant to be composed of an N-long-chain acyl amino acid and a basic amino acid, wherein the basic amino acid is present in an amount that partially neutralizes the N-long-chain acyl amino acid, preferably with a neutralization degree of 85% or more and less than 100%, more preferably with a neutralization degree of 88% or more and less than 96%; Alternatively, the main surfactant is selected to be composed of N-long-chain acyl amino acids, N-long-chain acyl amino acid dipeptides and basic amino acids, and the basic amino acids are present in an amount to partially neutralize the N-long-chain acyl amino acids and N-long-chain acyl amino acid dipeptides, preferably with a neutralization degree of more than 85% and less than 100%, and more preferably with a neutralization degree of more than 88% and less than 96%.

19. The method for improving the deodorizing performance in shampoo according to claim 18, characterized in that: The N-long-chain acyl amino acid is lauroylalanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroylalanylalanine.

20. A method for imparting oil control properties to a shampoo, characterized in that: The shampoo comprises (a) a main surfactant, (b) a co-surfactant, and (c) water, wherein the weight percentage of the main surfactant in all surfactants exceeds 50 wt %, preferably exceeds 65 wt %, and more preferably exceeds 80 wt %; The method for imparting oil control properties to shampoo comprises: selecting a primary surfactant to be composed of N-long-chain acyl amino acids and basic amino acids; Alternatively, the primary surfactant is selected to consist of an N-long chain acyl amino acid, an N-long chain acyl amino acid dipeptide and a basic amino acid.

21. The method for imparting oil control properties to shampoo according to claim 20, characterized in that: The N-long-chain acyl amino acid is lauroylalanine, the basic amino acid is arginine, and the N-long-chain acyl amino acid dipeptide is lauroylalanylalanine.

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