Process for extracting lipophilic effective components in vegetable drugs

Abstract

The invention discloses a process for extracting lipophilic effective components in plant medicines. The process comprises the following steps: S1, pretreatment of the plant medicines; s2, adding propylene glycol into deionized water, uniformly stirring to obtain a propylene glycol aqueous solution, then adding decapolyglycerol monostearate and lecithin, and continuously stirring for 1-2 hours to obtain an extraction solvent; s3, adding the pretreated plant medicinal materials into the extraction solvent in the step S2, extracting, centrifuging after the extraction is completed, and separating out supernate; and S4, filtering the supernate in the step S3 to obtain a finished product. The extraction method provided by the invention can effectively improve the extraction rate of lipophilic active ingredients, such as alkylamide in echinacea purpurea and kavalactone in Kava pepper, in the plant medicine, and has a good application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of extraction technology, and in particular relates to a process for extracting lipophilic active ingredients in plant medicines. Background Art

[0002] After thousands of years of practice, the research on natural medicinal plants has accumulated a wealth of valuable experience and gradually formed a systematic theory of traditional Chinese medicine and a unique academic system. It is unique in the world of medicine and is a splendid culture of the Chinese nation. A key area of ​​its modern application is the extraction and separation of active ingredients.

[0003] There are many kinds of natural plants, all of which contain a variety of effective and complex chemical components. These components can be divided into organic acids, volatile oils, coumarins, steroids, glycosides, alkaloids, sugars, plant pigments, etc. The extraction and separation technology of active ingredients in plants is determined according to the physical and chemical properties such as the existence state, shape, solubility, etc. of the active ingredients in plants under different conditions. The widely used separation technologies can be divided into membrane separation and traditional separation methods. The traditional separation method is divided into steam distillation, sublimation, cold soaking, precipitation, percolation, decoction, Soxhlet extraction, etc.

[0004] The active ingredients in herbal medicines include hydrophilic compounds and lipophilic compounds. The former can be extracted using water, while the latter have poor solubility in water and therefore require organic solvents for extraction. Among the many organic solvents, ethanol is the least toxic and can be consumed. Therefore, ethanol or ethanol aqueous solutions of different concentrations are currently recognized and most widely used solvents for extracting active ingredients in herbal medicines.

[0005] Echinacea (also known as coneflower) is a medicinal plant native to North America. Before Europeans set foot on the New World, Echinacea had a medicinal history of more than 400 years. It was later introduced to Europe and has been used ever since. At present, Echinacea has become one of the most widely used herbal medicines in the world. Polyphenolic acids and alkylamides are the main hydrophilic and lipophilic active ingredients in Echinacea, respectively. Kava is a perennial upright shrub medicinal plant of the Piperaceae family. It is produced in the South Pacific islands. Its roots and rhizomes are used as medicine, and the effective part is fat-soluble resin. In recent years, Kava has been used as a food supplement by people in many countries around the world to regulate insomnia and psychological problems such as stress, anxiety, and depression. The main active ingredient of Kava is kavalactone.

[0006] At present, in industrial production, the extraction of alkylamides in Echinacea or kavalactones in Kava is usually divided into two steps: the first step is to extract by heating with ethanol (such as 70% ethanol) or at room temperature; the second step is to heat and concentrate the extract to remove or partially remove ethanol from the extract. The advantages of this process are: 1. Even though there are safety concerns about the use and administration of ethanol, ethanol-water solution is still the most widely used solvent in the extraction of herbal medicines known to date. 2. Alkylamides and kavalactones are lipophilic compounds and are insoluble in water, so high concentrations of ethanol (such as 70% ethanol) become one of the best choices for their extraction. However, this process still has some defects, such as: alkylamides and kavalactones are a class of heat-inlaboratory compounds. When the ethanol extract is heated and concentrated, alkylamides and kavalactones will be lost due to heat, and their content will drop significantly; although ethanol is safe to take within a certain amount, it still has certain toxicity and addictiveness, and is not suitable for pregnant women, children, and drivers and operators of vehicles and mobile machinery; concentrating and volatilizing ethanol is time-consuming, resulting in a long time for the entire process; ethanol is a flammable and explosive hazardous chemical with a flash point of 13°C. Various safety operating guidelines must be strictly followed during production, but there are still safety hazards. Products containing high concentrations of ethanol must also comply with hazardous chemical regulations during transportation; ethanol has a low boiling point of 78°C and is easy to volatilize during the production process, which can cause inhalation risks to operators; when concentrating and volatilizing ethanol, waste liquid and waste gas will be produced, and the emission treatment will pollute the environment; the price of food-grade ethanol is relatively high, resulting in high production costs.

[0007] Therefore, it is necessary to develop a non-toxic, green, environmentally friendly, and low-cost extraction process to extract the fat-soluble active ingredients in herbal medicines and reduce the degradation of the active ingredients. Summary of the invention

[0008] In view of the shortcomings of the prior art, the object of the present invention is to provide a process for extracting lipophilic active ingredients in botanicals, which has higher safety and lower cost than ethanol, and at the same time has a higher extraction rate for lipophilic active ingredients in botanicals, such as alkylamides in Echinacea and kavalactones in kava.

[0009] To achieve the above object, the present invention provides the following technical solutions:

[0010] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0011] S1. Pretreatment of botanical medicinal materials: ultrafinely grinding the botanical medicinal materials, then adding them into an alkaline solution for soaking, filtering them after soaking, washing and drying the solid products, then adding them into a tannic acid solution for microwave treatment, filtering and drying them after treatment to obtain pretreated botanical medicinal materials;

[0012] S2, add propylene glycol to deionized water, stir evenly to obtain a propylene glycol aqueous solution, then add polyglycerol monostearate and lecithin, continue stirring for 1-2h, and obtain an extraction solvent;

[0013] S3, extracting effective ingredients: adding the pretreated botanical medicinal materials to the extraction solvent in step S2, extracting, centrifuging after the extraction is completed, and separating the supernatant;

[0014] S4, post-processing: the supernatant in step S3 is filtered to obtain a finished product.

[0015] Preferably, the botanical medicinal material in step S1 is one of Echinacea and Kava Piper methysticum.

[0016] Preferably, in step S1, the ultrafine grinding is performed to 300 mesh, the pH value of the alkaline solution is 11-12, the soaking temperature is 30-40°C, and the soaking time is 1-2h; the mass concentration of the tannic acid solution is 4-8%, the microwave treatment power is 400-500W, and the soaking time is 5-8min.

[0017] In the present invention, the specific surface area of ​​the medicinal material is increased by ultrafine grinding, and the alkali solution soaking and tannic acid treatment can destroy the plant cell wall structure, which is beneficial to the subsequent release of effective ingredients. At the same time, microwave treatment can effectively destroy the plant cell wall structure and increase cell permeability. The treatment time is short, which can reduce the degradation of heat-sensitive effective ingredients alkylamide or kavalactone.

[0018] Preferably, the mass concentration of propylene glycol in the propylene glycol aqueous solution in step S2 is 60-90%, the amount of decaglycerol monostearate added is 1-2% of the mass of the propylene glycol aqueous solution, and the amount of lecithin added is 3-4% of the mass of the propylene glycol aqueous solution.

[0019] In the present invention, propylene glycol aqueous solution is used as the extraction solvent. Propylene glycol is a colorless, slightly sweet organic solvent widely used in the pharmaceutical, food and cosmetic industries. It is a diol with 3 carbon atoms and 2 hydroxyl groups. Due to its strong hydrophilicity, it has been used to extract hydrophilic components in botanicals, such as polyphenols, but has not yet been used in the extraction of lipophilic components in botanicals. The added polyglycerol monostearate and lecithin serve as solubilizers and emulsifiers. This combination can form a microemulsion system, which can significantly improve the solubility and extraction efficiency of fat-soluble components.

[0020] Preferably, the stirring speed in step S2 is 300-400 r / min, the temperature is 40-50° C., and the time is 1-2 h.

[0021] Preferably, the solid-liquid ratio of the pretreated botanical material to the extraction solvent in step S3 is 1:(3-10).

[0022] Preferably, the specific extraction process in step S3 is: extracting for 1-2 hours at an ultrasonic treatment frequency of 20-100 kHz and a temperature of 55-65° C., with the frequency preferably being 20 kHz.

[0023] In the present invention, ultrasound-assisted extraction is used to generate a large number of microbubbles in plant tissues through the cavitation effect. When these bubbles burst, local high temperature and high pressure and microjet effects will be generated, which can effectively destroy the plant cell wall structure and enhance mass transfer. At the same time, the mechanical vibration effect of ultrasound can improve the penetration capacity of the solvent, promote the rapid dissolution of active ingredients, and extract the extraction rate and efficiency of active ingredients.

[0024] Preferably, the specific extraction process in step S3 is: extracting at a temperature of 55-65° C. for 7-10 hours.

[0025] Preferably, the specific extraction process in step S3 is: adding the pretreated botanical material to the extraction solvent at room temperature and soaking for 5-8 hours, then adding it to the percolator for percolation treatment at a flow rate of 1-2 mL / min.

[0026] In the present invention, ultrasound, heat extraction and room temperature percolation extraction can be used to extract the fat-soluble effective components in the botanical medicinal materials, and the most suitable extraction method can be selected according to the characteristics of different botanical medicinal materials.

[0027] Preferably, a 0.45 μm filter membrane is used for filtration in step S4, and pressure filtration is performed at 0.1-0.2 MPa.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) The process for extracting lipophilic active ingredients from botanical medicines provided by the present invention comprises pre-treating botanical medicines, ultrafine grinding to increase the specific surface area of ​​the medicines, and alkali solution soaking and tannic acid treatment to destroy the plant cell wall structure, which is beneficial to the subsequent release of active ingredients. Meanwhile, microwave treatment can effectively destroy the plant cell wall structure and increase cell permeability. The treatment time is short, which can reduce the degradation of heat-sensitive active ingredients such as alkylamides or kavalactones.

[0030] (2) The process for extracting lipophilic active ingredients from botanical medicines provided by the present invention adopts a propylene glycol-water mixed system as a base solvent. Propylene glycol has good solubility and permeability. The added polyglycerol monostearate serves as a nonionic surfactant, which can reduce the interfacial tension of the propylene glycol-water system and provide excellent emulsifying properties. Lecithin, as an amphiphilic molecule, can form a unique liposome-like structure. The two can be used in combination to form a stable composite interface film and a microemulsion structure with self-assembly characteristics. This structure significantly enhances the solubilization ability of fat-soluble active ingredients, while improving the contact effect between the extraction solvent and the medicinal material, providing a good protection and carrier environment for the poorly soluble and heat-sensitive ingredients such as alkylamides or kavalactones.

[0031] (3) The process for extracting lipophilic active ingredients from botanical medicines provided by the present invention does not use traditional ethanol as an extraction solvent, and does not require subsequent heating and concentration treatment. Compared with ethanol extraction, there is no loss of heat-resistant active ingredients, which greatly improves production efficiency and reduces production costs. The propylene glycol production process does not produce waste liquid and waste gas, and has no negative impact on the environment. At the same time, propylene glycol is not flammable or explosive. Its flash point is 107°C, which is safer and more stable than ethanol, and its boiling point is higher at 188°C. It is not easy to volatilize during the production process, and the risk of inhalation by operators is extremely low. It significantly improves the safe production environment and promotes environmental sustainability and protection, thereby realizing the industrial scale and industrialization of the extraction of active ingredients, especially lipophilic active ingredients, from botanical medicines. DETAILED DESCRIPTION

[0032] The technical solution of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] Example 1

[0034] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0035] S1. Pretreatment of Echinacea: 50 g of Echinacea was ultrafinely ground, then added into 500 mL of alkaline solution with a pH value of 12 for soaking at a temperature of 35° C. for 1.5 h. After soaking, the solid product was filtered, washed with deionized water until neutral, dried at 60° C. for 8 h, then added into 500 mL of a 6% tannic acid aqueous solution, and microwaved for 7 min at a power of 450 W. After the treatment, the solid product was filtered and dried to obtain pretreated Echinacea;

[0036] S2, preparation of extraction solvent: 750g of propylene glycol was added to 250g of deionized water, and 15g of decaglycerol monostearate and 35g of lecithin were added after stirring at a speed of 350r / min and a temperature of 45°C for 1.5h, and stirring was continued for 1.5h to obtain an extraction solvent;

[0037] S3, extracting effective ingredients: adding 50 g of pretreated Echinacea to 400 g of the extraction solvent in step S2, extracting for 1.5 h at an ultrasonic frequency of 20 kHz and a temperature of 60° C., centrifuging after the extraction is completed, and separating the supernatant;

[0038] S4, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.15 MPa to obtain a finished product.

[0039] Example 2

[0040] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0041] S1. Pretreatment of Echinacea: 50 g of Echinacea was ultrafinely ground, then added into 500 mL of alkaline solution with a pH value of 12 for soaking, the soaking temperature was 30° C., the time was 2 h, filtered after soaking, the solid product was washed with deionized water until neutral, dried at 60° C. for 8 h, then added into 500 mL of tannic acid aqueous solution with a mass concentration of 4%, microwaved at a power of 400 W for 8 min, filtered and dried after the treatment, to obtain pretreated Echinacea;

[0042] S2, preparation of extraction solvent: 600g of propylene glycol was added to 400g of deionized water, and 10g of decaglycerol monostearate and 40g of lecithin were added after stirring at a speed of 300r / min and a temperature of 40°C for 2h, and stirring was continued for 2h to obtain an extraction solvent;

[0043] S3, extracting effective ingredients: adding 50 g of pretreated Echinacea to 400 g of the extraction solvent in step S2, extracting at a temperature of 55° C. for 10 h, centrifuging after the extraction is completed, and separating the supernatant;

[0044] S4, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.1 MPa to obtain a finished product.

[0045] Example 3

[0046] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0047] S1. Pretreatment of Echinacea: 50 g of Echinacea was ultrafinely ground, then added into 500 mL of alkaline solution with a pH value of 12 for soaking, the soaking temperature was 40° C., the time was 2 h, filtered after soaking, the solid product was washed with deionized water until neutral, dried at 60° C. for 8 h, then added into 500 mL of tannic acid aqueous solution with a mass concentration of 8%, microwaved at a power of 500 W for 5 min, filtered and dried after the treatment, to obtain pretreated Echinacea;

[0048] S2, preparation of extraction solvent: 900g of propylene glycol was added to 100g of deionized water, and 20g of decaglycerol monostearate and 30g of lecithin were added after stirring at a speed of 400r / min and a temperature of 50°C for 1h, and stirring was continued for 1h to obtain an extraction solvent;

[0049] S3, extracting active ingredients: adding 50 g of pretreated Echinacea to 500 g of the extraction solvent in step S2 and immersing for 8 h, then adding to a percolator and performing percolation treatment at a flow rate of 1 mL / min. After the extraction is completed, centrifuge to separate the supernatant;

[0050] S4, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.2 MPa to obtain a finished product.

[0051] Example 4

[0052] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0053] S1, pretreatment of Piper mesenteriae kava: 50g Piper mesenteriae kava was ultrafinely ground, then added into 500mL alkali solution with pH value of 12 for soaking, the soaking temperature was 35°C, the time was 1.5h, filtered after soaking, the solid product was washed with deionized water until neutral, dried at 60°C for 8h, then added into 500mL tannic acid aqueous solution with mass concentration of 6%, microwaved at power of 450W for 7min, filtered and dried after treatment to obtain pretreated Piper mesenteriae kava;

[0054] S2, preparation of extraction solvent: 750g of propylene glycol was added to 250g of deionized water, and 15g of decaglycerol monostearate and 35g of lecithin were added after stirring at a speed of 350r / min and a temperature of 45°C for 1.5h, and stirring was continued for 1.5h to obtain an extraction solvent;

[0055] S3, extracting effective ingredients: adding 50 g of pretreated Kava Piper methysticum to 300 g of the extraction solvent in step S2, extracting for 1.5 h at an ultrasonic frequency of 50 kHz and a temperature of 60° C., centrifuging after the extraction is completed, and separating the supernatant;

[0056] S4, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.15 MPa to obtain a finished product.

[0057] Example 5

[0058] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0059] S1, pretreatment of Piper mesenteriae kava: 50g Piper mesenteriae kava was ultrafinely ground, then added into 500mL alkali solution with pH value of 12 for soaking, the soaking temperature was 30°C, the time was 2h, filtered after soaking, the solid product was washed with deionized water until neutral, dried at 60°C for 8h, then added into 500mL tannic acid aqueous solution with mass concentration of 4%, microwaved at power of 400W for 8min, filtered and dried after treatment to obtain pretreated Piper mesenteriae kava;

[0060] S2, preparation of extraction solvent: 600g of propylene glycol was added to 400g of deionized water, and 10g of decaglycerol monostearate and 40g of lecithin were added after stirring at a speed of 300r / min and a temperature of 40°C for 2h, and stirring was continued for 2h to obtain an extraction solvent;

[0061] S3, extracting effective ingredients: adding 50g of pretreated Piper mesenteriae kava to 300g of the extraction solvent in step S2, extracting at a temperature of 55°C for 10h, centrifuging after the extraction is completed, and separating the supernatant;

[0062] S4, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.1 MPa to obtain a finished product.

[0063] Example 6

[0064] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0065] S1, pretreatment of Piper mesenteriae kava: 50g Piper mesenteriae kava was ultrafinely ground, then added into 500mL alkali solution with pH value of 12 for soaking, the soaking temperature was 40°C, the time was 2h, filtered after soaking, the solid product was washed with deionized water until neutral, dried at 60°C for 8h, then added into 500mL tannic acid aqueous solution with mass concentration of 8%, microwaved at power of 500W for 5min, filtered and dried after treatment to obtain pretreated Piper mesenteriae kava;

[0066] S2, preparation of extraction solvent: 800g of propylene glycol was added to 200g of deionized water, and 20g of decaglycerol monostearate and 30g of lecithin were added after stirring at a speed of 400r / min and a temperature of 50°C for 1h, and stirring was continued for 1h to obtain an extraction solvent;

[0067] S3, extracting active ingredients: adding 50 g of pretreated Kava Piper methysticum to 500 g of the extraction solvent in step S2 and immersing for 8 h, then adding it to a percolator for percolation at a flow rate of 2 mL / min, centrifuging after the extraction is completed, and separating the supernatant;

[0068] S4, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.2 MPa to obtain a finished product.

[0069] Comparative Example 1

[0070] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0071] S1. Pretreatment of Echinacea: 50 g of Echinacea was ultrafinely ground, then added into 500 mL of alkaline solution with a pH value of 12 for soaking at a temperature of 35° C. for 1.5 h. After soaking, the solid product was filtered, washed with deionized water until neutral, dried at 60° C. for 8 h, then added into 500 mL of a 6% tannic acid aqueous solution, and microwaved for 7 min at a power of 450 W. After the treatment, the solid product was filtered and dried to obtain pretreated Echinacea;

[0072] S2, extracting effective ingredients: adding 50 g of pretreated Echinacea to 400 g of ethanol aqueous solution (the mass concentration of ethanol is 75%) in step S2, extracting for 1.5 h at an ultrasonic frequency of 20 kHz and a temperature of 60° C., centrifuging after the extraction is completed, and separating the supernatant;

[0073] S3, post-processing: The supernatant in step S2 is filtered using a 0.45 μm filter membrane at 0.15 MPa to obtain a finished product.

[0074] Comparative Example 2

[0075] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0076] S1, preparation of extraction solvent: 750g of propylene glycol was added to 250g of deionized water, and 15g of decaglycerol monostearate and 35g of lecithin were added after stirring at a speed of 350r / min and a temperature of 45°C for 1.5h, and stirring was continued for 1.5h to obtain an extraction solvent;

[0077] S2, extracting effective ingredients: adding 50 g of Echinacea to 400 g of the extraction solvent in step S1, extracting for 1.5 h at an ultrasonic frequency of 20 kHz and a temperature of 60° C., centrifuging after the extraction is completed, and separating the supernatant;

[0078] S3, post-processing: The supernatant in step S2 is filtered using a 0.45 μm filter membrane at 0.15 MPa to obtain a finished product.

[0079] Comparative Example 3

[0080] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0081] S1, pretreatment of Piper mesenteriae kava: 50g Piper mesenteriae kava was ultrafinely ground, then added into 500mL alkali solution with pH value of 12 for soaking, the soaking temperature was 35°C, the time was 1.5h, filtered after soaking, the solid product was washed with deionized water until neutral, dried at 60°C for 8h, then added into 500mL tannic acid aqueous solution with mass concentration of 6%, microwaved at power of 450W for 7min, filtered and dried after treatment to obtain pretreated Piper mesenteriae kava;

[0082] S2, extracting effective ingredients: 50g of pretreated Kava Piper methysticum was added to 300g of ethanol aqueous solution (the mass concentration of ethanol was 75%), and extracted for 1.5h at an ultrasonic frequency of 50kHz and a temperature of 60°C. After the extraction was completed, the mixture was centrifuged to separate the supernatant;

[0083] S3, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.15 MPa to obtain a finished product.

[0084] Comparative Example 4

[0085] A process for extracting lipophilic active ingredients from herbal medicines, comprising the following steps:

[0086] S1, preparation of extraction solvent: 750g of propylene glycol was added to 250g of deionized water, and 15g of decaglycerol monostearate and 35g of lecithin were added after stirring at a speed of 350r / min and a temperature of 45°C for 1.5h, and stirring was continued for 1.5h to obtain an extraction solvent;

[0087] S2, extracting effective ingredients: adding 50g of Piper mesona pulex to 300g of the extraction solvent in step S1, extracting for 1.5h at an ultrasonic frequency of 50kHz and a temperature of 60°C, centrifuging after the extraction is completed, and separating the supernatant;

[0088] S3, post-processing: The supernatant in step S3 is filtered using a 0.45 μm filter membrane at 0.15 MPa to obtain a finished product.

[0089] The extraction rates of the active ingredients in the botanical medicines in Examples 1-6 and Comparative Examples 1-4 were compared, and the results are shown in Table 1 below:

[0090] Table 1 Comparison of extraction rates of active ingredients in different groups of herbal medicines

[0091]

[0092]

[0093] It can be seen from Table 1 above that, compared with ethanol extraction, the extraction method provided by the present invention can effectively improve the extraction rate of alkylamides in Echinacea and kavalactones in Kava Piper methysticum, and has good application prospects.

[0094] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A process for extracting lipophilic active ingredients from herbal medicines, characterized in that: The following steps are involved: S1, ultrafinely grinding the botanical material, then adding it into an alkaline solution for soaking, filtering it after the soaking, washing and drying the solid product, then adding it into a tannic acid solution for microwave treatment, filtering and drying it after the treatment to obtain a pretreated botanical material; S2, add propylene glycol to deionized water, stir evenly to obtain a propylene glycol aqueous solution, then add polyglycerol monostearate and lecithin, continue stirring for 1-2h, and obtain an extraction solvent; S3, adding the pretreated botanical material to the extraction solvent in step S2, extracting, and centrifuging after the extraction is completed to separate the supernatant; S4: Filter the supernatant in step S3 to obtain a finished product.

2. The process according to claim 1, characterized in that The botanical medicinal material in step S1 is one of Echinacea and Kava Piper methysticum.

3. The process according to claim 1, characterized in that In step S1, the particles are ultrafinely ground to 300 meshes, the pH value of the alkaline solution is 11-12, the soaking temperature is 30-40° C., and the soaking time is 1-2 hours; the mass concentration of the tannic acid solution is 4-8%, the microwave treatment power is 400-500 W, and the soaking time is 5-8 minutes.

4. The process according to claim 1, characterized in that The mass concentration of propylene glycol in the propylene glycol aqueous solution in step S2 is 60-90%, the amount of decaglycerol monostearate added is 1-2% of the mass of the propylene glycol aqueous solution, and the amount of lecithin added is 3-4% of the mass of the propylene glycol aqueous solution.

5. The process according to claim 1, characterized in that The stirring speed in step S2 is 300-400 r / min, the temperature is 40-50° C., and the time is 1-2 h.

6. The process according to claim 1, characterized in that The solid-liquid ratio of the pretreated botanical material to the extraction solvent in step S3 is 1:(3-10).

7. The process according to claim 1, characterized in that The specific extraction process in step S3 is: extracting for 1-2 hours at a frequency of 20-100 kHz and a temperature of 55-65°C for ultrasonic treatment.

8. The process according to claim 1, characterized in that The specific extraction process in step S3 is: extracting at a temperature of 55-65° C. for 7-10 hours.

9. The process according to claim 1, characterized in that The specific extraction process in step S3 is: adding the pretreated botanical material to the extraction solvent at room temperature and soaking for 5-8 hours, then adding it to the percolator for percolation treatment at a flow rate of 1-2 mL / min.

10. The process according to claim 1, characterized in that In step S4, a 0.45 μm filter membrane is used for filtration, and pressure filtration is performed at 0.1-0.2 MPa.

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