Composition for preventing and treating rice blast diseases

Abstract

The invention relates to the technical field of compositions for preventing and treating rice blast diseases, and discloses a composition for preventing and treating rice blast diseases, which is prepared from the following raw materials in parts by weight: 10 to 20 parts of tricyclazole, 20 to 30 parts of tebuconazole, 5 to 15 parts of pyraclostrobin, 3 to 8 parts of bacillus subtilis and 5 to 10 parts of auxiliaries, the auxiliary agent comprises the following raw materials in percentage: 10%-35% of a dispersing agent, 5%-25% of a wetting agent, 5%-20% of a stabilizing agent, 1%-10% of a defoaming agent and 5%-20% of an anti-freezing agent. According to the composition, tricyclazole and tebuconazole are combined, so that the problem that the prevention and treatment cost is increased due to the fact that a single or few chemical agents are used in a traditional composition for preventing and treating the rice blast diseases for a long time, so that the rice blast bacteria generate drug resistance, and the agents need to be continuously increased is solved.

Description

Technical Field

[0001] The invention relates to the technical field of compositions for preventing and controlling rice blast diseases, in particular to a composition for preventing and controlling rice blast diseases. Background Art

[0002] Rice can be infected with rice blast from seedling to maturity. Due to the different periods and parts of rice affected, it is divided into seedling blast, leaf blast, node blast, panicle blast and grain blast. Seedling blast occurs before the 3-leaf stage of seedlings, and the diseased seedlings are yellow-brown to gray-brown and die. Leaf blast lesions are of chronic and acute types. Chronic lesions are spindle-shaped, grayish white in the center, reddish brown on the edges, and yellow on the periphery. There are brown "necrotic lines" extending along the veins at both ends of the lesions, and gray-green fungi and mold on the back of the spots. Acute lesions are oval, dark green, and water-soaked, with dense gray-green fungi and mold on the back of the spots. The affected parts of the ligule, auricle or pulvinus are dark brown to gray-black. The pulvinus lesions are irregular and often cause leaf breaks. Node blast lesions spread in a ring along the stem nodes, the diseased nodes turn black, shrink and sag, the stems bend or even break, the panicle blast or branch blast is light brown or gray-black, rots and breaks, and the grains are not full or even white ears. The grain blast spots are gray-brown with gray-white in the middle, and most of them are empty or half-filled grains. The pathogenicity of rice blast: The pathogen mainly overwinters in diseased stalks and diseased grains, becoming the primary infection source of early rice in the following year. When the temperature is 20℃~30℃ and the relative humidity is above 90%, it is favorable for the disease. The rapid growth during the tillering stage, the greening during the heading stage, the early rice encountering 3 to 4 days of rain during the heading stage, and the late rice encountering 5 to 7 days of cooling and heavy dew and fog weather, it is easy to induce leaf blast or ear blast.

[0003] Traditional compositions for controlling rice blast have long used a single or a few chemical agents, and rice blast fungi are prone to develop resistance to these chemical agents. Once the fungi develop resistance, the control effect of the composition for controlling rice blast will be significantly reduced, resulting in the need to continuously increase the dosage of the agent or replace the agent, thereby increasing the cost of control. Summary of the invention

[0004] In view of the deficiencies in the prior art, the present invention provides a composition for preventing and controlling rice blast disease, which solves the problem that traditional compositions for preventing and controlling rice blast disease use a single or a few chemical agents for a long time. Rice blast fungi are prone to develop resistance to these chemical agents. Once the fungi develop resistance, the prevention and control effect of the composition for preventing and controlling rice blast disease will be significantly reduced, resulting in the need to continuously increase the dosage of the agent or replace the agent, thereby increasing the prevention and control cost.

[0005] To achieve the above objectives, the present invention is implemented through the following technical scheme: a composition for preventing and controlling rice blast disease, the composition for preventing and controlling rice blast disease comprising the following raw materials in parts by weight: 10-20 parts of tricyclazole, 20-30 parts of tebuconazole, 5-15 parts of pyraclostrobin, 3-8 parts of Bacillus subtilis and 5-10 parts of an adjuvant.

[0006] Preferably, the auxiliary agent includes the following raw materials in percentage: dispersant 10%-35%, wetting agent 5%-25%, stabilizer 5%-20%, defoaming agent 1%-10%, antifreeze agent 5%-20%.

[0007] Preferably, the dispersant comprises the following raw materials in percentage: 30%-60% of polycarboxylate dispersant, 20%-40% of lignin sulfonate dispersant, and 10%-30% of alkylnaphthalene sulfonate dispersant.

[0008] Preferably, the wetting agent comprises the following raw materials in percentage: 30%-50% sodium dodecyl sulfate, 20%-40% sodium alkylbenzene sulfonate, and 10%-30% fatty alcohol polyoxyethylene ether wetting agent.

[0009] Preferably, the stabilizer comprises the following raw materials in percentage: 30%-50% citric acid, 20%-40% triethanolamine, 10%-30% butylated hydroxytoluene, and 20%-30% purified water.

[0010] Preferably, the defoamer comprises the following raw materials in percentage: 60%-80% of silicone defoamer, 10%-30% of polyether defoamer, 10%-20% of high-carbon alcohol defoamer, and 5%-20% of ethanol.

[0011] Preferably, the antifreeze agent comprises the following raw materials in percentage: 40%-60% ethylene glycol, 30%-50% propylene glycol, 10%-20% glycerol, and 7%-20% ethanol.

[0012] A preparation process of a composition for preventing and controlling rice blast disease comprises the following steps:

[0013] S1. Raw material preparation: weigh each component according to the formula;

[0014] S2, crushing: tricyclazole, tebuconazole and pyraclostrobin are respectively placed in a jet mill, and crushed by the jet mill, the air flow speed is set at 50m-200m per second, the crushing time is 30 minutes-180 minutes, and the particle size of the material is detected in real time by a laser particle size analyzer set inside the crusher, and the particle size of the material is controlled to be between 5-15 microns;

[0015] S3, mixing: using a double-helix conical mixer, first preliminarily mixing tricyclazole, tebuconazole and pyraclostrobin for 30 minutes to form a mixture, and then pouring Bacillus subtilis into the mixture four times with an interval of 15 minutes each time, each time being 25% of the total amount of Bacillus subtilis, and continuing to mix for 25 minutes after all the amounts of Bacillus subtilis are added, and the double-helix conical mixer does not stop during the whole mixing process;

[0016] S4. Additive treatment:

[0017] Dispersant treatment: put the dispersant into the air flow mill, set the air flow speed of the air flow mill to 35m-150m per second, and the crushing time to 20 minutes-45 minutes. After crushing, the dispersant with a particle size between 7-13 microns will be discharged from the screen on the side wall of the air flow mill, and the dispersant exceeding the particle size range will be driven by the air flow to continue to be crushed;

[0018] Wetting agent treatment: Add the wetting agent into the electric stirrer, set the stirring speed of the electric stirrer between 80-200 revolutions per minute, and set the stirring time to 5-15 minutes;

[0019] Stabilizer treatment: add purified water into the heating stirrer, start the heating component of the heating stirrer, control the temperature of purified water at 75 degrees Celsius, add stabilizer, start the stirring module of the heating stirrer, control the stirring speed between 60-120 revolutions per minute, control the stirring time at 25-40 minutes, and keep the temperature during the whole process;

[0020] Defoamer treatment: Pour ethanol and defoamer into the stirrer, start the stirrer, keep the speed between 60-150 revolutions per minute, and control the stirring time between 5-15 minutes;

[0021] Antifreeze treatment: start the heating module of the heating stirrer, preheat the heating stirrer to 50 degrees Celsius, put the antifreeze into the heating stirrer, increase the temperature of the heating stirrer to 85 degrees Celsius until all the antifreeze is melted, add ethanol, start the stirring module, control the stirring speed between 60-140 revolutions per minute, and control the stirring time between 25-40 minutes;

[0022] S5, secondary mixing: adding the additive processed in S4 to the mixture in S3, using a high-speed stirrer to mix, controlling the stirring speed between 120-360 revolutions per minute, controlling the mixing temperature between 20-30 degrees Celsius, controlling the mixing humidity between 5%-15%, and controlling the mixing time between 30-60 minutes;

[0023] S6. Quality testing: Conduct active ingredient content determination, particle size analysis and stability testing on the finished product.

[0024] The present invention provides a composition for preventing and treating rice blast disease. It has the following beneficial effects:

[0025] 1. In the present invention, the combination of tricyclazole and tebuconazole can inhibit the biosynthesis of ergosterol on the fungal cell membrane while inhibiting the synthesis of melanin in rice blast fungus, thereby improving the traditional composition for controlling rice blast disease, which uses a single or a few chemical agents for a long time, causing the rice blast fungus to develop drug resistance, resulting in the need to continuously increase the dosage of the agent or replace the agent, thereby causing the problem of increased control costs.

[0026] 2. In the present invention, by adding a combination of pyraclostrobin and Bacillus subtilis, rice can be induced to produce systemic resistance and enhance the disease resistance of rice itself, thereby improving the prevention and control effect and reducing the impact of chemical agents on the environment and the generation of drug resistance, thereby achieving the effect of protecting the environment.

[0027] 3. In the present invention, by arranging a laser particle size analyzer inside the air flow mill, the particle sizes of tricyclazole, tebuconazole and pyraclostrobin during pulverization can be detected in real time, thereby achieving pulverization without stopping the machine and achieving the desired pulverization effect, thereby saving process production time. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 It is a flow chart of the manufacturing process of the present invention. DETAILED DESCRIPTION

[0029] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] Please see attached Figure 1 The embodiment of the present invention provides a composition for preventing and controlling rice blast disease, comprising the following raw materials in parts by weight: 10-20 parts of tricyclazole, 20-30 parts of tebuconazole, 5-15 parts of pyraclostrobin, 3-8 parts of Bacillus subtilis and 5-10 parts of an auxiliary agent, wherein tricyclazole is used to inhibit the synthesis of melanin of rice blast fungus, and tricyclazole can have a good preventive effect on rice blast disease, tebuconazole is used to inhibit the biosynthesis of ergosterol on fungal cell membrane, and tebuconazole can further prevent and control rice blast disease, pyraclostrobin is used to kill the infected rice blast fungus and stimulate the growth of rice to improve stress resistance, pyraclostrobin can inhibit the mitochondrial respiration of rice blast fungus, destroy the energy metabolism of the fungus, thereby preventing the growth and reproduction of the fungus, Bacillus subtilis is used to inhibit the growth of rice blast fungus and induce rice to produce systemic resistance, and the auxiliary agent is used to improve the stability of the composition and the dispersion, wetting and other properties of the composition on rice, and the auxiliary agent can enhance the preventive effect of the composition for preventing and controlling rice blast disease.

[0031] The auxiliary agent comprises the following raw materials in percentage: dispersant 10%-35%, wetting agent 5%-25%, stabilizer 5%-20%, defoamer 1%-10%, antifreeze agent 5%-20%.

[0032] The dispersant is used to evenly disperse the active ingredients in the composition in water or other solvents. The dispersant includes the following raw materials in percentage: 30%-60% of polycarboxylate dispersant, 20%-40% of lignin sulfonate dispersant, and 10%-30% of alkylnaphthalene sulfonate dispersant. The dispersant can prevent the composition from agglomerating.

[0033] The wetting agent is used to improve the wetting performance of the composition on the surface of rice leaves and the like. The wetting agent includes the following raw materials in percentage: 30%-50% sodium dodecyl sulfate, 20%-40% sodium alkylbenzene sulfonate, and 10%-30% fatty alcohol polyoxyethylene ether wetting agent. The wetting agent can enhance the adhesion of the agent.

[0034] The stabilizer is used to improve the stability of the composition during storage and use. The stabilizer includes the following raw materials in percentage: 30%-50% citric acid, 20%-40% triethanolamine, 10%-30% butylated hydroxytoluene, and 20%-30% purified water. The stabilizer can prevent the effective ingredients from decomposing or deteriorating.

[0035] Defoaming agent is used to eliminate foam generated during the production and use process. The defoaming agent includes the following raw materials in percentage: 60%-80% silicone defoaming agent, 10%-30% polyether defoaming agent, 10%-20% high carbon alcohol defoaming agent, and 5%-20% ethanol. Defoaming agent is used to eliminate foam, thereby ensuring smooth production and use effect.

[0036] The antifreeze agent is used to prevent the composition from freezing in a low-temperature environment. The antifreeze agent includes the following raw materials in percentage: 40%-60% ethylene glycol, 30%-50% propylene glycol, 10%-20% glycerol, and 7%-20% ethanol. The antifreeze agent allows the composition to be used normally in a low-temperature environment.

[0037] A preparation process of a composition for preventing and controlling rice blast disease comprises the following steps:

[0038] S1. Raw material preparation: weigh each component according to the formula;

[0039] S2, crushing: tricyclazole, tebuconazole and pyraclostrobin are respectively placed in a jet mill, and crushed by the jet mill, the air flow speed is set at 50m-200m per second, the crushing time is 30 minutes-180 minutes, and the particle size of the material is detected in real time by a laser particle size analyzer set inside the crusher, and the particle size of the material is controlled to be between 5-15 microns;

[0040] S3, mixing: using a double-helix conical mixer, first preliminarily mixing tricyclazole, tebuconazole and pyraclostrobin for 30 minutes to form a mixture, and then pouring Bacillus subtilis into the mixture four times with an interval of 15 minutes each time, each time being 25% of the total amount of Bacillus subtilis, and continuing to mix for 25 minutes after all the amounts of Bacillus subtilis are added, and the double-helix conical mixer does not stop during the whole mixing process;

[0041] S4. Additive treatment:

[0042] Dispersant treatment: put the dispersant into the air flow mill, set the air flow speed of the air flow mill to 35m-150m per second, and the crushing time to 20 minutes-45 minutes. After crushing, the dispersant with a particle size between 7-13 microns will be discharged from the screen on the side wall of the air flow mill, and the dispersant exceeding the particle size range will be driven by the air flow to continue to be crushed;

[0043] Wetting agent treatment: Add the wetting agent into the electric stirrer, set the stirring speed of the electric stirrer between 80-200 revolutions per minute, and set the stirring time to 5-15 minutes;

[0044] Stabilizer treatment: add purified water into the heating stirrer, start the heating component of the heating stirrer, control the temperature of purified water at 75 degrees Celsius, add stabilizer, start the stirring module of the heating stirrer, control the stirring speed between 60-120 revolutions per minute, control the stirring time at 25-40 minutes, and keep the temperature during the whole process;

[0045] Defoamer treatment: Pour ethanol and defoamer into the stirrer, start the stirrer, keep the speed between 60-150 revolutions per minute, and control the stirring time between 5-15 minutes;

[0046] Antifreeze treatment: start the heating module of the heating stirrer, preheat the heating stirrer to 50 degrees Celsius, put the antifreeze into the heating stirrer, increase the temperature of the heating stirrer to 85 degrees Celsius until all the antifreeze is melted, add ethanol, start the stirring module, control the stirring speed between 60-140 revolutions per minute, and control the stirring time between 25-40 minutes;

[0047] S5, secondary mixing: adding the additive processed in S4 to the mixture in S3, using a high-speed stirrer to mix, controlling the stirring speed between 120-360 revolutions per minute, controlling the mixing temperature between 20-30 degrees Celsius, controlling the mixing humidity between 5%-15%, and controlling the mixing time between 30-60 minutes;

[0048] S6. Quality testing: Conduct active ingredient content determination, particle size analysis and stability testing on the finished product.

[0049] The following is further introduced in conjunction with specific embodiments:

[0050] Embodiment 1:

[0051] The weight parts of raw materials in a composition for preventing and controlling rice blast disease are 10 parts of tricyclazole, 20 parts of tebuconazole, 5 parts of pyraclostrobin, 3 parts of Bacillus subtilis and 5 parts of an adjuvant.

[0052] The preparation process of the above-mentioned composition for preventing and controlling rice blast disease comprises the following steps:

[0053] S1. Raw material preparation: weigh each component according to the formula;

[0054] S2, crushing: tricyclazole, tebuconazole and pyraclostrobin are respectively placed in a jet mill, and crushed by the jet mill, the air flow speed is set at 50m-200m per second, the crushing time is 30 minutes-180 minutes, and the particle size of the material is detected in real time by a laser particle size analyzer set inside the crusher, and the particle size of the material is controlled to be between 5-15 microns;

[0055] S3, mixing: using a double-helix conical mixer, first preliminarily mixing tricyclazole, tebuconazole and pyraclostrobin for 30 minutes to form a mixture, and then pouring Bacillus subtilis into the mixture four times with an interval of 15 minutes each time, each time being 25% of the total amount of Bacillus subtilis, and continuing to mix for 25 minutes after all the amounts of Bacillus subtilis are added, and the double-helix conical mixer does not stop during the whole mixing process;

[0056] S4. Additive treatment:

[0057] Dispersant treatment: put the dispersant into the air flow mill, set the air flow speed of the air flow mill to 35m-150m per second, and the crushing time to 20 minutes-45 minutes. After crushing, the dispersant with a particle size between 7-13 microns will be discharged from the screen on the side wall of the air flow mill, and the dispersant exceeding the particle size range will be driven by the air flow to continue to be crushed;

[0058] Wetting agent treatment: Add the wetting agent into the electric stirrer, set the stirring speed of the electric stirrer between 80-200 revolutions per minute, and set the stirring time to 5-15 minutes;

[0059] Stabilizer treatment: add purified water into the heating stirrer, start the heating component of the heating stirrer, control the temperature of purified water at 75 degrees Celsius, add stabilizer, start the stirring module of the heating stirrer, control the stirring speed between 60-120 revolutions per minute, control the stirring time at 25-40 minutes, and keep the temperature during the whole process;

[0060] Defoamer treatment: Pour ethanol and defoamer into the stirrer, start the stirrer, keep the speed between 60-150 revolutions per minute, and control the stirring time between 5-15 minutes;

[0061] Antifreeze treatment: start the heating module of the heating stirrer, preheat the heating stirrer to 50 degrees Celsius, put the antifreeze into the heating stirrer, increase the temperature of the heating stirrer to 85 degrees Celsius until all the antifreeze is melted, add ethanol, start the stirring module, control the stirring speed between 60-140 revolutions per minute, and control the stirring time between 25-40 minutes;

[0062] S5, secondary mixing: adding the additive processed in S4 to the mixture in S3, using a high-speed stirrer to mix, controlling the stirring speed between 120-360 revolutions per minute, controlling the mixing temperature between 20-30 degrees Celsius, controlling the mixing humidity between 5%-15%, and controlling the mixing time between 30-60 minutes;

[0063] S6. Quality testing: Conduct active ingredient content determination, particle size analysis and stability testing on the finished product.

[0064] Embodiment 2:

[0065] The difference between this embodiment and the above-mentioned embodiment 1 is that:

[0066] 15 parts of tricyclazole, 25 parts of tebuconazole, 10 parts of pyraclostrobin, 5 parts of Bacillus subtilis and 7 parts of adjuvant.

[0067] Embodiment 3:

[0068] The difference between this embodiment and the above-mentioned embodiment 1 and embodiment 2 is that:

[0069] 20 parts of tricyclazole, 30 parts of tebuconazole, 15 parts of pyraclostrobin, 8 parts of bacillus subtilis and 10 parts of auxiliary agent.

[0070] Table 1:

[0071] contrast Example 1 Example 2 Example 3 Standard value Disease index (%) 30 20 10 50 Colony diameter (mm) 15 10 2 20

[0072] The comparison in Table 1 is the disease index and the colony diameter. The composition for controlling rice blast disease of Examples 1-3 is applied under the same conditions. The ratio of the number of diseased plants to the total number of investigated plants after continuous application for 7 days is the disease index. The standard value in Table 1 is obtained from an experiment in which the raw materials of the composition for controlling rice blast disease are only tebuconazole and an adjuvant. By changing the raw material components in each example, the results of Examples 1-3 in Table 1 are obtained through experiments. Table 1 shows that the combination of tricyclazole and tebuconazole and the addition of pyraclostrobin and Bacillus subtilis can effectively improve the drug resistance of rice blast.

[0073] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A composition for preventing and controlling rice blast disease, characterized in that: The composition for preventing and controlling rice blast disease comprises the following raw materials in parts by weight: 10-20 parts of tricyclazole, 20-30 parts of tebuconazole, 5-15 parts of pyraclostrobin, 3-8 parts of bacillus subtilis and 5-10 parts of an adjuvant.

2. A composition for preventing and controlling rice blast disease according to claim 1, characterized in that: The auxiliary agent comprises the following raw materials in percentage: 10%-35% of dispersant, 5%-25% of wetting agent, 5%-20% of stabilizer, 1%-10% of defoaming agent and 5%-20% of antifreeze agent.

3. A composition for preventing and controlling rice blast disease according to claim 2, characterized in that: The dispersant comprises the following raw materials in percentage: 30%-60% of polycarboxylate dispersant, 20%-40% of lignin sulfonate dispersant, and 10%-30% of alkyl naphthalene sulfonate dispersant.

4. A composition for preventing and controlling rice blast disease according to claim 2, characterized in that: The wetting agent comprises the following raw materials in percentage: 30%-50% of sodium lauryl sulfate, 20%-40% of sodium alkylbenzene sulfonate, and 10%-30% of fatty alcohol polyoxyethylene ether wetting agent.

5. A composition for preventing and controlling rice blast disease according to claim 2, characterized in that: The stabilizer comprises the following raw materials in percentage: 30%-50% of citric acid, 20%-40% of triethanolamine, 10%-30% of butylated hydroxytoluene and 20%-30% of purified water.

6. A composition for preventing and controlling rice blast disease according to claim 2, characterized in that: The defoamer comprises the following raw materials in percentage: 60%-80% of organosilicon defoamer, 10%-30% of polyether defoamer, 10%-20% of high-carbon alcohol defoamer and 5%-20% of ethanol.

7. A composition for preventing and controlling rice blast disease according to claim 2, characterized in that: The antifreeze agent comprises the following raw materials in percentage: 40%-60% of ethylene glycol, 30%-50% of propylene glycol, 10%-20% of glycerol and 7%-20% of ethanol.

8. A process for preparing a composition for preventing and controlling rice blast disease according to any one of claims 1 to 7, comprising the following steps: S1. Raw material preparation: weigh each component according to the formula; S2, crushing: tricyclazole, tebuconazole and pyraclostrobin are respectively placed in a jet mill, and crushed by the jet mill, the air flow speed is set at 50m-200m per second, the crushing time is 30 minutes-180 minutes, and the particle size of the material is detected in real time by a laser particle size analyzer set inside the crusher, and the particle size of the material is controlled to be between 5-15 microns; S3, mixing: using a double-helix conical mixer, first preliminarily mixing tricyclazole, tebuconazole and pyraclostrobin for 30 minutes to form a mixture, and then pouring Bacillus subtilis into the mixture four times with an interval of 15 minutes each time, each time being 25% of the total amount of Bacillus subtilis, and continuing to mix for 25 minutes after all the amounts of Bacillus subtilis are added, and the double-helix conical mixer does not stop during the whole mixing process; S4. Additive treatment: Dispersant treatment: put the dispersant into the air flow mill, set the air flow speed of the air flow mill to 35m-150m per second, and the crushing time to 20 minutes-45 minutes. After crushing, the dispersant with a particle size between 7-13 microns will be discharged from the screen on the side wall of the air flow mill, and the dispersant exceeding the particle size range will be driven by the air flow to continue to be crushed; Wetting agent treatment: Add the wetting agent into the electric stirrer, set the stirring speed of the electric stirrer between 80-200 revolutions per minute, and the stirring time is set to 5-15 minutes; Stabilizer treatment: add purified water into the heating stirrer, start the heating component of the heating stirrer, control the temperature of purified water at 75 degrees Celsius, add stabilizer, start the stirring module of the heating stirrer, control the stirring speed between 60-120 revolutions per minute, control the stirring time at 25-40 minutes, and keep the temperature during the whole process; Defoamer treatment: Pour ethanol and defoamer into the stirrer, start the stirrer, keep the speed between 60-150 revolutions per minute, and control the stirring time between 5-15 minutes; Antifreeze treatment: start the heating module of the heating stirrer, preheat the heating stirrer to 50 degrees Celsius, put the antifreeze into the heating stirrer, increase the temperature of the heating stirrer to 85 degrees Celsius until all the antifreeze is melted, add ethanol, start the stirring module, control the stirring speed between 60-140 revolutions per minute, and control the stirring time between 25-40 minutes; S5, secondary mixing: adding the additive processed in S4 to the mixture in S3, using a high-speed stirrer to mix, controlling the stirring speed between 120-360 revolutions per minute, controlling the mixing temperature between 20-30 degrees Celsius, controlling the mixing humidity between 5%-15%, and controlling the mixing time between 30-60 minutes; S6. Quality testing: Conduct active ingredient content determination, particle size analysis and stability testing on the finished product.

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