Skin bacteriostatic cream and preparation method thereof

Abstract

The invention relates to the field of bacteriostatic cream, and particularly discloses skin bacteriostatic cream and a preparation method thereof. The skin antibacterial cream is prepared from the following raw materials in parts by weight: 4 to 6 parts of bran coat extract, 2 to 4 parts of chlorhexidine salt, 2 to 4 parts of rutin extract, 1 to 3 parts of carnosine, 0.5 to 0.8 part of sodium hyaluronate, 0.8 to 1.2 parts of film-forming agent and 5 to 8 parts of purified water. The preparation method comprises the following steps: mixing the film-forming agent and a part of water, and uniformly stirring to obtain a film-forming agent solution; the preparation method comprises the following steps: mixing sodium hyaluronate and water, heating, stirring until the sodium hyaluronate and the water are completely dissolved, adding the cavings extract, the rutin extract, the chlorhexidine salt and the carnosine, stirring until the mixture is uniformly dispersed, heating to 75-85 DEG C, emulsifying for 25-35 minutes, homogenizing, adding a film-forming agent solution into the homogenized emulsion, and stirring, concentrating, degassing and discharging the paste in vacuum to obtain the antibacterial paste. The composition can be used for diminishing inflammation and resisting bacteria of damaged skin, and has the advantages of being high in antibacterial rate and capable of avoiding skin pigmentation.

Description

Technical Field

[0001] The present application relates to the field of antibacterial cream, and more specifically, to a skin antibacterial cream and a preparation method thereof. Background Art

[0002] With the acceleration of the pace of modern life, skin problems are increasing. The human skin is a hotbed for various fungi and bacteria. Every day, countless fungi and bacteria grow and reproduce on the skin, causing various skin problems such as acne, dermatitis, eczema, etc. These problems not only affect the appearance, but may also cause more serious health problems. As a common topical drug, skin antibacterial cream is widely used to treat skin diseases caused by bacterial infections. It effectively relieves skin discomfort caused by bacterial infections through its anti-inflammatory and bactericidal mechanisms.

[0003] However, in actual application, some products have poor antibacterial effects. In particular, existing antibacterial creams cannot alleviate the problem of pigmentation after skin inflammation, affecting the beauty of the skin. Summary of the invention

[0004] In order to obtain an antibacterial cream with good antibacterial effect and capable of preventing skin pigmentation, the present application provides a skin antibacterial cream and a preparation method thereof.

[0005] On the one hand, the present application provides a skin antibacterial cream, which adopts the following technical solution: A skin antibacterial cream, comprising the following raw materials in parts by weight: 4-6 parts of bran extract, 2-4 parts of chlorhexidine salt, 2-4 parts of rutin extract, 1-3 parts of carnosine, 0.5-0.8 parts of sodium hyaluronate, 0.8-1.2 parts of film-forming agent, and 5-8 parts of purified water.

[0006] By adopting the above technical solution, the natural high-quality substances rich in the bran extract can play a role in moisturizing and improving dryness. The nutrients and antioxidants therein help soothe the skin, reduce itching and redness, promote blood circulation, and relieve skin discomfort. At the same time, it can effectively inhibit the production of tyrosinase, thereby inhibiting the production of melanin. At the same time, with its stable antioxidant effect, it can effectively organize the aging and dullness of wound skin. Rutin extract is a natural flavonoid compound with strong antioxidant ability and scavenges free radicals. It can inhibit the growth and reproduction of bacteria on the skin surface while enhancing skin immunity and promoting the metabolism of skin cells. The two cooperate with each other to improve the ability of the antibacterial cream to kill bacteria and repair the skin.

[0007] Carnosine can inhibit inflammatory responses, improve skin redness and pain, remove excess free radicals from the skin, and reduce oxidative stress damage to the skin, thereby reducing the occurrence of skin aging and improving skin elasticity and glossiness.

[0008] Film-forming agents can form a protective film on the skin surface, which can prevent the volatilization of nutrients and moisturizing ingredients on the one hand, and prevent the invasion of external pollutants and harmful bacteria on the other hand. When used in combination with substances such as bran extracts, it can effectively protect the skin from damage.

[0009] The skin antibacterial cream prepared from the above components achieves multiple functions such as antibacterial, moisturizing, anti-oxidation and repair through the synergistic effect of multiple ingredients. The bran extract and rutin extract provide rich nutrients and antioxidants, which are helpful to improve the skin condition; chlorhexidine salt, as the main antibacterial ingredient, can quickly kill or inhibit pathogenic bacteria on the skin surface, and at the same time, it is combined with the bran extract to improve the anti-inflammatory and antibacterial effect of the bran extract, promote each other, and improve the antibacterial broad spectrum of the antibacterial cream; carnosine and sodium hyaluronate respectively enhance the product's antioxidant and moisturizing properties; the film-forming agent plays a role in protecting the skin and prolonging the efficacy of the drug. These ingredients work together to make the skin antibacterial cream show significant beneficial effects in improving skin health, preventing and treating skin infections.

[0010] Optionally, the raw materials further include 0.4-0.8 parts of polyhexamethylene biguanide hydrochloride.

[0011] By adopting the above technical solution, polyhexamethylene biguanide hydrochloride can destroy the cell membrane structure of microorganisms, form transmembrane pores, destroy the energy metabolism of microorganisms, and then kill microorganisms. It mainly acts on the cell membrane and respiratory tract of microorganisms, and cooperates with chlorhexidine salts that have strong oxidizing properties to destroy the protein and nucleic acid structure of microorganisms. The two work synergistically to further kill microorganisms through multi-pathway sterilization methods and reduce drug resistance.

[0012] Optionally, the bran extract is prepared by the following method: (1) Wash and dry the bran, heat the bran at 110-130° C. for 10-20 min using infrared, and crush and sieve the dried bran sample; (2) adding an extraction solvent to the crushed bran sample, ultrasonically treating it at a power of 220-250 W for 20-30 min, filtering and extracting it 2-3 times, and combining the filtrate; (3) adding acidified methanol to the filter residue for extraction 2-3 times, setting the extraction pressure to 25-30 MPa and the temperature to 40-50° C., collecting the extract and the filtrate, combining them and concentrating them under vacuum to obtain a concentrate; (4) freeze-drying the concentrated solution for 2-3 days and sieving to obtain the bran extract.

[0013] By adopting the above technical scheme, the bran samples are subjected to infrared heating treatment, which inhibits the activity of lipase substances in the bran, reduces the moisture content in the bran, delays the oxidative rancidity of millet bran, reduces the generation of free fatty acids and peroxides, reduces the generation of undesirable substances, and enables subsequent extracts to contain more beneficial ingredients.

[0014] Isopropyl alcohol has a large polarity, and combined with the complex oscillation, emulsification, diffusion, and crushing effects produced by ultrasound during the vibration process, it accelerates the rupture of bran cells in the solvent, allowing the extracted substances to diffuse and precipitate more quickly, and extracting active ingredients such as vitamin E, squalene, and oryzanol in the bran to the greatest extent. These ingredients can inhibit tyrosinase, reduce the production of melanin, and prevent pigmentation of wound skin. At the same time, substances such as oryzanol can also inhibit the growth of skin pathogenic fungi.

[0015] Acidified methanol is further used to extract polyphenols from the bran. Polyphenols have good antioxidant activity and can remove free radicals to prevent these free radicals from damaging skin cells and causing cell aging. Further polyphenols have moisturizing and whitening effects and can protect the health of the skin. This extraction method can be used to extract the active ingredients in the bran to the greatest extent, and at the same time, it can extract the nutrients in the bran that are beneficial to the recovery of the hand skin and the prevention of pigmentation, improve the synergy between the bran extract and other raw materials, improve its anti-inflammatory and bactericidal effects, and enhance the effect of the antibacterial cream in repairing damaged skin and preventing pigmentation.

[0016] Optionally, the extraction solvent is a mixed solvent of isopropanol and n-hexane in a weight ratio of 1:2-4.

[0017] By adopting the above technical scheme, an appropriate proportion of extraction solvents can fully extract the beneficial active ingredients in the bran, which play their respective different extraction effects, can better dissolve the target extract, reduce the dissolution of unnecessary components, and improve the extraction effect of the bran extract on specific components.

[0018] Optionally, during the vacuum concentration process, the vacuum degree is controlled to be ≥-0.05MPa, and the concentration is stopped at 40-60°C until the relative density is between 1.07-1.20, and the concentrated solution is allowed to cool to room temperature to obtain a concentrated solution.

[0019] By adopting the above technical scheme and through precise control of the vacuum concentration operation, the content of free fatty acids in the extract is reduced, so that the bran extract can better exert its antibacterial and anti-inflammatory effects, improve its interaction with other raw materials in the antibacterial cream, and improve the antibacterial effect of the antibacterial cream.

[0020] Optionally, the film-forming agent is polyvinyl pyrrolidone.

[0021] By adopting the above technical solution, polyvinyl pyrrolidone, a non-ionic polymer compound with good film-forming properties, water solubility, physiological compatibility and permeability, can form a uniform and transparent film in the antibacterial cream, which helps to protect the skin and prolong the action time of the antibacterial ingredients, while helping the penetration and absorption of the nutrients in the antibacterial cream, further improving the effect of the antibacterial cream.

[0022] Optionally, the raw materials also include 0.3-0.5 parts of a polyol moisturizer.

[0023] By adopting the above technical solution, polyols can not only effectively lock the moisture inside the skin and maintain the moisture of the skin, but also absorb moisture from the atmosphere to further enhance the moisturizing effect. In addition, polyols also have good antioxidant properties and synergize with the active ingredients in the bran extract to better neutralize the damage of free radicals to the skin and slow down the process of skin aging. At the same time, its anti-inflammatory effect can also reduce the inflammatory response on the skin surface, which is especially suitable for sensitive skin.

[0024] In a second aspect, the present application provides a method for preparing a skin antibacterial cream, using the following technical solution: A method for preparing a skin antibacterial cream comprises the following steps: (1) Mixing a film-forming agent and a portion of water, stirring evenly to obtain a film-forming agent solution, and setting aside for later use; (2) Mixing sodium hyaluronate and the remaining water, heating, stirring until completely dissolved, adding bran extract, rutin extract, chlorhexidine salt and carnosine and stirring until uniformly dispersed, heating to 75-85° C., emulsifying for 25-35 minutes and homogenizing, adding a film-forming agent solution to the homogenized emulsion, stirring under vacuum, degassing, and forming an ointment to obtain the antibacterial ointment.

[0025] In summary, this application has the following beneficial effects: 1. The skin antibacterial cream in this application not only achieves a broad-spectrum antibacterial effect and effectively kills or inhibits pathogenic bacteria on the skin surface by carefully proportioning various ingredients such as bran extract, chlorhexidine salt, rutin extract, etc., but also utilizes the rich nutrients and bactericidal and antioxidant substances of bran extract and rutin extract to improve skin condition, promote skin repair, reduce pigmentation, and comprehensively protect skin health.

[0026] 2. In the present application, polyhexamethylene biguanide hydrochloride is preferably added. Through the synergistic effect of polyhexamethylene biguanide hydrochloride and chlorhexidine salt, the bactericidal ability of the antibacterial cream is further enhanced through a multi-pathway bactericidal mechanism, effectively reducing the development of drug resistance.

[0027] 3. The special preparation process of the bran extract ensures the complete retention of its active ingredients, which together with other ingredients enhances the overall effectiveness of the antibacterial cream.

[0028] 4. Polyvinyl pyrrolidone is used as a film-forming agent to form a uniform and breathable protective film on the skin surface, effectively preventing the invasion of external pollutants and harmful bacteria, while locking in nutrients and moisturizing factors to prolong the efficacy of the drug. This film-forming property also promotes the deep penetration and absorption of nutrients in the antibacterial cream, providing lasting nourishment and protection for the skin, accelerating the skin repair process, and improving the overall skin care effect. DETAILED DESCRIPTION

[0029] The present application is further described in detail below with reference to the embodiments.

[0030] If the specific conditions are not specified in the examples, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer. If the manufacturers of the reagents or instruments are not specified, they are all conventional products that can be purchased commercially.

[0031] Acidified methanol: 10 ml formic acid was added to 500 ml methanol; polyhexamethylene biguanide hydrochloride was purchased from Hubei Yamade Biopharmaceutical Co., Ltd., CAS No.: 32289-58-0; rutin extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., specification NF11≥98%.

[0032] Preparation examples of raw materials and / or intermediates Preparation Example 1 A bran extract, the preparation of which comprises the following steps: (1) Wash and dry the bran, heat the bran at 120°C for 15 min using infrared, and grind the dried bran sample through an 80-mesh sieve; (2) 10 kg of the above-mentioned crushed bran sample was added with 5 kg of isopropanol and 15 kg of n-hexane, and ultrasonically treated at 250 W for 25 min, then filtered and extracted three times, and the filtrates were combined; (3) adding 15 kg of acidified methanol to the filter residue for extraction twice, setting the extraction pressure to 26 MPa and the temperature to 45° C., collecting the extract and the filtrate, combining them, and concentrating them in a vacuum at -0.04 MPa and 50° C. until the relative density reaches 1.10, and then stopping the concentration to obtain a concentrated solution; (4) freeze-drying the concentrated solution for 2 days, and sieving to obtain the bran extract.

[0033] Preparation Example 2 A bran extract, the preparation of which comprises the following steps: (1) Wash and dry the bran, heat the bran at 120°C for 15 min using infrared, and grind the dried bran sample through an 80-mesh sieve; (2) 10 kg of the above-mentioned crushed bran sample was added to 3.75 kg of isopropanol and 11.25 kg of n-hexane, and ultrasonically treated at 220 W for 30 min, then filtered and extracted twice, and the filtrates were combined; (3) adding 15 kg of acidified methanol to the filter residue for extraction three times, setting the extraction pressure to 25 MPa and the temperature to 50° C., collecting the extract and combining the filtrate, and concentrating in vacuo at -0.05 MPa and 40° C. until the relative density reaches 1.07, and then stopping the concentration to obtain a concentrated solution; (4) freeze-drying the concentrated solution for 3 days, and sieving to obtain the bran extract.

[0034] Preparation Example 3 A bran extract, the preparation of which comprises the following steps: (1) Wash and dry the bran, heat the bran at 120°C for 15 min using infrared, and grind the dried bran sample through an 80-mesh sieve; (2) 10 kg of the above-mentioned crushed bran sample was added with 3 kg of isopropanol and 12 kg of n-hexane, and ultrasonically treated at 235 W for 20 min, then filtered and extracted three times, and the filtrates were combined; (3) adding 15 kg of acidified methanol to the filter residue for extraction twice, setting the extraction pressure to 30 MPa and the temperature to 40° C., collecting the extract and combining the filtrate, and concentrating in a vacuum at -0.05 MPa and 60° C. until the relative density reaches 1.20, and then stopping the concentration to obtain a concentrated solution; (4) freeze-drying the concentrated solution for 3 days, and sieving to obtain the bran extract.

[0035] Comparative Preparation Example 1 A bran extract, the preparation of which comprises the following steps: (1) Wash and dry the bran, heat the bran at 120°C for 15 min using infrared, and grind the dried bran sample through an 80-mesh sieve; (2) adding 3 kg of isopropanol to 10 kg of the above-mentioned crushed bran sample, ultrasonically treating at 250 W for 25 min, filtering and extracting for 3 times, combining the filtrates; and concentrating in vacuo at -0.04 MPa and 50° C. until the relative density reaches 1.10, thereby obtaining a concentrated solution; (3) freeze-drying the concentrated solution for 2 days and sieving to obtain the bran extract. Example

[0036] Example 1 A skin antibacterial cream, the preparation of which comprises the following steps: (1) Mix 1 kg of polyvinyl pyrrolidone (film-forming agent) and 2 kg of water, stir evenly to obtain a film-forming agent solution, and set aside for later use; (2) 0.65 kg of sodium hyaluronate and 4.5 kg of water were mixed, heated to 30° C., stirred until completely dissolved, and then 5 kg of rice bran extract, 3 kg of rutin extract, 3 kg of chlorhexidine acetate and 1 kg of carnosine were added and stirred until uniformly dispersed, and the mixture was heated to 80° C., mechanically stirred and emulsified for 30 min, and then homogenized. The film-forming agent solution in step (1) was added to the homogenized emulsion, and the mixture was stirred at -0.05 MPa and 70° C., degassed, and formed into a paste to obtain the antibacterial paste; the rice bran extract was prepared in Preparation Example 1.

[0037] Example 2 A skin antibacterial cream, the preparation of which comprises the following steps: (1) 0.8 kg of polyvinyl pyrrolidone (film-forming agent) and 2 kg of water were mixed and stirred to obtain a film-forming agent solution, which was set aside for later use; (2) 0.8 kg of sodium hyaluronate and 3 kg of water were mixed, heated to 30° C., stirred until completely dissolved, and then 6 kg of rice bran extract, 2 kg of rutin extract, 4 kg of chlorhexidine acetate and 2 kg of carnosine were added and stirred until uniformly dispersed, and the mixture was heated to 75° C., mechanically stirred and emulsified for 35 min, and then homogenized. The film-forming agent solution in step (1) was added to the homogenized emulsion, and the mixture was stirred at -0.05 MPa and 70° C., degassed, and formed into a paste to obtain the antibacterial paste; the rice bran extract was prepared in Preparation Example 1.

[0038] Example 3 A skin antibacterial cream, the preparation of which comprises the following steps: (1) 1.2 kg of polyvinyl pyrrolidone (film-forming agent) and 2 kg of water were mixed and stirred to obtain a film-forming agent solution, which was set aside for later use; (2) 0.5 kg of sodium hyaluronate and 6 kg of water were mixed, heated to 30° C., stirred until completely dissolved, and then 4 kg of rice bran extract, 4 kg of rutin extract, 2 kg of chlorhexidine acetate and 3 kg of carnosine were added and stirred until uniformly dispersed, and the mixture was heated to 85° C., mechanically stirred and emulsified for 25 min, and then homogenized. The film-forming agent solution in step (1) was added to the homogenized emulsion, and the mixture was stirred at -0.05 MPa and 70° C., degassed, and formed into a paste to obtain the antibacterial paste; the rice bran extract was prepared in Preparation Example 1.

[0039] Example 4 A skin antibacterial cream, which is different from Example 1 in that the bran extract used in this example is prepared in Preparation Example 2.

[0040] Example 5 A skin antibacterial cream, which is different from Example 1 in that the bran extract used in this example is prepared in Preparation Example 3.

[0041] Example 6 A skin antibacterial cream, which is different from Example 1 in that 0.4 kg of polyhexamethylene biguanide hydrochloride is further added in this example, and comprises the following steps: (1) 1.2 kg of polyvinyl pyrrolidone (film-forming agent) and 2 kg of water were mixed and stirred to obtain a film-forming agent solution, which was set aside for later use; (2) 0.5 kg of sodium hyaluronate and 6 kg of water are mixed, heated to 30° C., stirred until completely dissolved, and then 4 kg of bran extract, 4 kg of rutin extract, 2 kg of chlorhexidine acetate, 0.4 kg of polyhexamethylene biguanide hydrochloride and 3 kg of carnosine are added and stirred until uniformly dispersed, the temperature is raised to 85° C., mechanically stirred and emulsified for 25 minutes, and then homogenized, the film-forming agent solution in step (1) is added to the homogenized emulsion, and the mixture is stirred at -0.05 MPa and 70° C., degassed, and a paste is obtained to obtain the antibacterial cream.

[0042] Example 7 A skin antibacterial cream, which is different from Example 6 in that 0.8 kg of polyhexamethylene biguanide hydrochloride is also added in this example.

[0043] Example 8 A skin antibacterial cream, which is different from Example 1 in that 0.3 kg of glycerol is further added in this example, and the preparation comprises the following steps: A skin antibacterial cream, the preparation of which comprises the following steps: (1) Mix 1 kg of polyvinyl pyrrolidone (film-forming agent) and 2 kg of water, stir evenly to obtain a film-forming agent solution, and set aside for later use; (2) 0.65 kg of sodium hyaluronate and 4.5 kg of water were mixed, heated to 30° C., stirred until completely dissolved, and then 5 kg of rice bran extract, 3 kg of rutin extract, 3 kg of chlorhexidine acetate, 1 kg of carnosine and 0.3 kg of glycerol were added and stirred until uniformly dispersed, and the mixture was heated to 80° C., mechanically stirred and emulsified for 30 min, and then homogenized. The film-forming agent solution in step (1) was added to the homogenized emulsion, and the mixture was stirred at -0.05 MPa and 70° C., degassed, and formed into a paste to obtain the antibacterial paste; the rice bran extract was prepared in Preparation Example 1.

[0044] Example 9 A skin antibacterial cream, which is different from Example 1 in that 0.5 kg of glycerol is also added in this example.

[0045] Comparative Example Comparative Example 1 A skin antibacterial cream, which is different from Example 1 in that no bran extract is added in this comparative example.

[0046] Comparative Example 2 A skin antibacterial cream, which is different from Example 1 in that no rutin extract is added in this comparative example.

[0047] Comparative Example 3 A skin antibacterial cream, which is different from Example 1 in that carnosine is not added in this comparative example.

[0048] Comparative Example 4 A skin antibacterial cream, which is different from Example 1 in that no chlorhexidine salt is added in this comparative example.

[0049] Comparative Example 5 A skin antibacterial cream, which is different from Example 1 in that the bran extract prepared in Comparative Preparation Example 1 is used in this comparative example.

[0050] Comparative Example 6 A skin antibacterial cream, which is different from Example 1 in that no film-forming agent is added in this comparative example.

[0051] Performance testing Detection method / test method Determination of antibacterial activity: The antibacterial rate of the product was tested according to Appendix C of GB15979-2002.

[0052] Potato (PDA) medium: 200g potato, 20g glucose, 20g agar, 1000mL sterile water. Peel 200g potato, cut into small pieces, add 1000mL water to a pot and boil for 30min, filter with four layers of gauze, take the filtrate, add glucose and agar, add sterile water to 1000mL, and sterilize at 121℃ for 20min.

[0053] Beef extract peptone medium: Take 10g beef extract, 5g peptone, 5g sodium chloride, 20g agar, add sterile water to 1000mL, adjust the pH to 7.4, and sterilize at 121℃ for 20min.

[0054] Preparation of test bacterial suspension: (1) Take out Staphylococcus aureus and Candida albicans from a 4°C refrigerator, inoculate them into PDA medium, and incubate them at 37°C for 24 hours for activation. Candida albicans is incubated at 28°C for 48 hours for activation. Pipette 1.0 ml of the stock solution into 9.0 ml of sterile water to obtain a 10-fold diluted suspension. Repeat the above steps until the dilution is 10. -3 (2) Inoculate Penicillium and Aspergillus niger into beef extract peptone medium for activation, rinse the spores with a certain amount of sterile water, and use turbidimetry to prepare a 110 cfu / mL bacterial suspension, which is then stored at 4°C for later use.

[0055] Four 5 ml portions of the antibacterial solution prepared in the examples and comparative examples were taken aseptically and numbered, and 100 μL of the bacterial suspension of each bacterial species was taken and added for 5 min to test the antibacterial rate of each sample.

[0056] Table 1 Antibacterial effect test results of antibacterial ointment Combining Examples 1-9 and Comparative Examples 1-5 and Table 1, it can be seen that the inhibition rates of Examples 1-9 on various bacteria are better than those of Comparative Examples 1-5, indicating that the various components of the skin antibacterial cream of the present application have a good synergistic effect and achieve a good antibacterial effect on common wound pathogens.

[0057] When bran extract, rutin extract, carnosine and chlorhexidine salt were not added to comparative examples 1-4, the antibacterial effect was reduced and the antibacterial effect did not reach the best, indicating that the several active ingredients in the present application need to be combined together to work synergistically to have a more significant bactericidal and anti-inflammatory effect.

[0058] Combining Example 1, Examples 4-5 and Comparative Example 5 and Table 1, it can be seen that the experimental data of Examples 1 and Examples 4-5 are better than those of Comparative Example 5. The method of extracting bran extract of the present application can extract more beneficial substances, kill bacteria and reduce inflammation, inhibit pigmentation, protect the skin, and can form good adaptation and synergy with other ingredients.

[0059] Combining Example 1 with Examples 6-7 and Table 1, it can be seen that the experimental data of Examples 6-7 are better than those of Example 1, indicating that the addition of polyhexamethylene biguanide hydrochloride can cooperate with other ingredients in the antibacterial cream to further improve the bactericidal and anti-inflammatory effects of the antibacterial cream.

[0060] Combining Example 1 with Examples 8-9 and Table 1, it can be seen that the experimental data of Examples 8-9 are better than those of Example 1, indicating that adding glycerol to the antibacterial cream can enhance the ability of the antibacterial cream to scavenge free radicals, while its good moisturizing property can further improve the skin's repair ability.

[0061] This experiment also randomly selected 160 patients with skin damage, infection and inflammation, and randomly divided them into the embodiment group, the comparative group and the control group by the method of random grouping of 10 people. The control group used ordinary alcohol for anti-inflammatory and sterilization. According to statistical tests, there was no significant difference in gender, age, course of disease, site of onset and severity of symptoms and signs among the patients, and they were comparable. All patients did not use other antibacterial drugs within 1 month. Since the beginning of the experiment, the antibacterial cream prepared in each embodiment and comparative example of the present application was applied to the wound, 2 times / day, and the condition of the affected part was observed every day. The experiment was terminated after 7 days, and the symptoms such as inflammation of the affected part of the embodiment group were observed to have disappeared. In particular, the patients using the antibacterial cream of Examples 6-7 had significantly improved symptoms at the end of the first day, and were basically cured on the third day, with a faster recovery rate than other groups, and no pigmentation was found in the skin color, and no white skin, dryness, etc. were found on the skin surface after recovery; the patients using the antibacterial cream of Examples 7-8 were basically cured on the fourth day, and no pigmentation was found in the skin color, and no white skin, dryness, etc. were found on the skin surface; Example groups 1-6 were basically cured at the end of the fifth day, and the symptoms of the other comparative example groups were alleviated on the sixth and seventh days, and they were cured, and some of them showed pigmentation, dryness and peeling; among them, there were more pigmentation and dryness and peeling in comparative example group 1, comparative example group 2, comparative example group 3 and comparative example group 5. On the seventh day, the wounds of the control group had scabs and fell off, and the skin surface showed pigmentation, darkening, dryness, and peeling.

[0062] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A skin antibacterial cream, characterized in that: The composition comprises the following raw materials in parts by weight: 4-6 parts of bran extract, 2-4 parts of chlorhexidine salt, 2-4 parts of rutin extract, 1-3 parts of carnosine, 0.5-0.8 parts of sodium hyaluronate, 0.8-1.2 parts of film-forming agent, and 5-8 parts of purified water.

2. A skin antibacterial cream according to claim 1, characterized in that: The raw materials also include 0.4-0.8 parts of polyhexamethylene biguanide hydrochloride.

3. A skin antibacterial cream according to claim 1, characterized in that: The bran extract is prepared by the following method: (1) Wash and dry the bran, heat it at 110-130°C for 10-20 min using infrared, and crush and sieve the dried bran sample; (2) adding an extraction solvent to the crushed bran sample, ultrasonically treating it at a power of 220-250W for 20-30min, filtering and extracting it 2-3 times, and combining the filtrates; (3) Add acidified methanol to the filter residue for extraction 2-3 times, set the extraction pressure to 25-30 MPa, and the temperature to 40-50°C, collect the extract and the filtrate, combine them and concentrate them under vacuum to obtain a concentrate; (4) freeze-drying the concentrated solution for 2-3 days and sieving to obtain the bran extract.

4. A skin antibacterial cream according to claim 3, characterized in that: The extraction solvent is a mixed solvent of isopropanol and n-hexane in a weight ratio of 1:2-4.

5. A skin antibacterial cream according to claim 3, characterized in that: During the vacuum concentration process, the vacuum degree is controlled to be ≥-0.05MPa, and the concentration is stopped at 40-60°C until the relative density is between 1.07-1.20, and the concentrated solution is allowed to cool to room temperature to obtain a concentrated solution.

6. A skin antibacterial cream according to claim 1, characterized in that: The film-forming agent is polyvinyl pyrrolidone.

7. A skin antibacterial cream according to claim 1, characterized in that: The raw materials also include 0.3-0.5 parts of a polyol moisturizer.

8. A method for preparing the antibacterial skin cream according to claim 1, characterized in that: The steps include: (1) Mix the film-forming agent and a portion of water, stir evenly to obtain a film-forming agent solution, and set aside for later use; (2) Mix sodium hyaluronate and the remaining water, heat and stir until completely dissolved, then add the bran extract, rutin extract, chlorhexidine salt and carnosine and stir until evenly dispersed, heat to 75-85° C., emulsify for 25-35 minutes and homogenize, add the film-forming agent solution to the homogenized emulsion, stir and concentrate under vacuum, deaerate and dispense into a paste to obtain the antibacterial paste.

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