Liver cancer detection device for liver epitope peptide determination

Abstract

The invention relates to the technical field of medical supplies, in particular to a liver cancer detection device for liver epitope peptide determination, which comprises a needle cylinder, a suction tube is rotatably matched in the needle cylinder, a piston is slidably matched in the suction tube, and a clamping mechanism for clamping the needle cylinder is arranged at the bottom of the suction tube; a plurality of mounting blocks are further arranged on the needle cylinder, mounting cavities are formed in the mounting blocks, and the mounting cavities communicate with one-way valves; the mounting blocks are annularly arranged with the suction pipe as the center, detection pipes and cleaning pipes are arranged in the mounting cavities, and the cleaning pipes are located between the adjacent detection pipes; the suction pipe is communicated with a liquid guide pipe and is respectively communicated with the cleaning pipe or the detection pipe through the liquid guide pipe and a one-way valve; different samples or reagents can be conveniently and continuously observed, mutual interference and pollution in the repeated observation process of the samples are reduced, and the accuracy of a detection result is further improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical supplies, and in particular to a liver cancer detection device for measuring liver epitope peptides. Background Art

[0002] It is generally believed that primary liver cancer or metastatic liver cancer is often the main cause of liver cancer recurrence. According to clinical and basic research results, hepatocellular carcinoma metastasis is mostly through blood circulation, followed by lymphatics, and can also directly spread, invade or implant other parts. Based on the current situation that the cure rate of primary liver cancer or metastatic liver cancer is relatively low and the recurrence rate is high, immunotherapy is considered to be a new method of tumor prevention and treatment with broad prospects. The body cannot respond to its own antigens due to immune tolerance, and exogenous immunity is expected to break immune tolerance, and improve immune response by targeting specific liver epitope peptide reactions, thereby delaying tumor progression, inhibiting tumor metastasis and even curing tumors.

[0003] The process of immunotherapy usually involves removing the tumorigenicity of the tumor patient's own or allogeneic primary liver cancer cells in vitro through methods such as enzymatic degradation of invasive components, ultrasonic oscillation, and high-temperature denaturation, while partially retaining their immunogenicity. The vaccine is made into a vaccine containing specific liver epitope peptides and is then infused back into the patient's body in order to stimulate a specific anti-liver cancer immune response.

[0004] During immunotherapy, the serum levels of antigens or antibodies in the blood vessels of liver cancer patients are significantly higher than those of normal people and patients with benign liver lesions, and the serum levels of liver cancer patients with metastasis are also significantly higher than those without metastasis. Therefore, serum levels of antigens or antibodies play an important role in the growth, infiltration, metastasis, treatment and prognosis of liver cancer. Therefore, in the prior art, serological detection of markers in serum is often used to detect liver cancer and determine liver cancer during treatment.

[0005] Although serological testing plays an important role in the diagnosis of liver cancer, since serological testing is performed through the specific binding of specific antigens and antibodies, it can often only detect a single pathogen or marker. In the process of detecting multiple pathogens or multiple disease markers, multiple reagents are required for detection. In the process of multiple detections, the sample is contaminated by the mixed impurities left over from different detection processes during collection or processing, interfering with the detection reaction and affecting the accuracy of the results. The reagent is contaminated by the mixed impurities left over from different detection processes during the reaction with the serum sample, interfering with the detection reaction and affecting the accuracy of the results. And the inaccurate sample addition amount due to operational errors affects the accuracy of the test results, and then false positive or false negative reactions occur. Therefore, the present invention provides an auxiliary liver cancer detection device that can cyclically sample, reduce the mutual interference or contamination of different samples or reagents during repeated observations, improve the accuracy of the test results, and facilitate the subsequent recycling of sample waste. Summary of the invention

[0006] To solve the above problems, the present invention provides a liver cancer detection device for liver epitope peptide determination, which is used for continuous observation of different samples or reagents, reducing mutual interference and contamination during repeated observation of samples, thereby improving the accuracy of the detection results.

[0007] In order to achieve the above-mentioned object, the technical scheme of the present invention is as follows: a liver cancer detection device for liver epitope peptide determination, comprising a syringe, a suction tube rotatably fitted in the syringe, a piston slidably fitted in the suction tube, and a clamping mechanism for clamping the syringe at the bottom of the suction tube;

[0008] The syringe is also provided with a number of mounting blocks, each of which has a mounting cavity, which is connected to a one-way valve; the mounting blocks are arranged in a ring shape with the suction tube as the center, and detection tubes and cleaning tubes are respectively provided in the mounting cavity, and the cleaning tubes are located between adjacent detection tubes; the suction tube is connected to a liquid guide tube, and the suction tube is connected to the cleaning tube or the detection tube through the liquid guide tube and the one-way valve.

[0009] The technical principles of the above scheme are as follows:

[0010] The clamping mechanism is driven to move during the movement of the piston to control the clamping mechanism to fix or loosen the needle tube, so as to facilitate the replacement of the needle tube and reduce interference in the process of extracting serum.

[0011] In the process of mixing the serum with different reagents, the aspiration tube is rotated to connect the liquid guide tube with different installation cavities to control the serum and the reagents.

[0012] The above scheme has the following beneficial effects:

[0013] 1. This solution enables the clamping mechanism to automatically fix and loosen the needle tube, making it easy to manually replace the needle tube to aspirate the serum and reducing interference and contamination of different sera.

[0014] 2. Compared with the prior art, this solution uses alternately arranged detection tubes and cleaning tubes. After the serum and reagent are mixed, they can be promptly flushed through the cleaning tubes to ensure cleaning efficiency, so as to achieve continuous detection of different markers.

[0015] 3. This solution uses an integrated device and adopts a rotating method to mix samples and clean the device. Compared with the separation and cleaning of the prior art, it reduces the processing steps and improves work efficiency.

[0016] Furthermore, a first rod is fixedly connected to the top of the piston, the first rod is slidably matched with the suction tube, and an end of the first rod away from the suction tube is fixedly connected to a handle.

[0017] Beneficial effect: The first rod can be easily moved by the handle to control the serum volume inside the suction tube.

[0018] Furthermore, one end of the clamping block away from the suction pipe is fixedly connected with a conical clamping block.

[0019] Beneficial effect: The clamping block is engaged and fixed with the bottom of the needle tube to improve the stability of the needle tube during the suction process, so as to facilitate the suction of serum.

[0020] Furthermore, it also includes an indicating mechanism, which includes an annular shielding cavity opened on the syringe, the shielding cavity is connected to the installation cavity through a one-way valve; and the top of the shielding cavity is also connected to a plurality of slide grooves, the slide grooves correspond to the positions of the detection tube or the cleaning tube, an indicating rod is slidably matched in the slide groove, a ball is hinged at the bottom of the indicating rod, and the ball is located in the shielding cavity; and the liquid guide tube is gap-matched with the shielding cavity;

[0021] When the liquid guiding tube contacts the ball, the ball is located above the shielding cavity, and the liquid guiding tube is connected with the cleaning tube or the detection tube; when the liquid guiding tube is separated from the ball, the ball is located in the shielding cavity, and the liquid guiding tube is separated from the cleaning tube or the detection tube.

[0022] Beneficial effects: The liquid guide tube slides in the shielding cavity and the ball is pushed to rotate, so that the indicator rod hinged to the ball is extended, and the connection position of the liquid guide tube is confirmed, so that the serum can react with the reagents in different detection tubes; at the same time, the detection tube or the cleaning tube is shielded by the ball to reduce the contact between the outside air and the detection tube, and reduce the contamination of the reagents in the detection tube by impurities entering the detection tube.

[0023] Furthermore, a magnet layer is fixedly connected inside the indicating rod, and a locking cavity is slidably matched inside the syringe, the position of the locking cavity corresponds to the position of the shielding cavity, and a first stopper is slidably matched inside the locking cavity, and a first spring is provided between the top of the first stopper and the syringe;

[0024] A second stopper is slidably fitted in the liquid guiding tube, the first stopper and the second stopper are both magnetic bodies driven by the attraction of the magnet, and a second spring is provided between the top of the second stopper and the liquid guiding tube;

[0025] When the catheter contacts the ball, the first block opens the detection tube or the cleaning tube, and the second block opens the catheter; when the catheter separates from the ball, the first block closes the detection tube or the cleaning tube, and the second block closes the catheter.

[0026] Beneficial effect: When the ball is located above the liquid guide tube, the magnetic force of the magnet layer adsorbs the first block to drive the first block to move upward, so that the position of the detection tube or the cleaning tube leaks out. At the same time, the ball adsorbs the second block through the magnet layer to drive the second block to move upward, so that the position of the liquid guide tube leaks out.

[0027] When the catheter leaves the ball position, the indicator rod falls naturally due to the influence of gravity, so that the ball is located in the shielding cavity. The first stopper is pushed by the magnet layer and the compressed spring to close the position of the detection tube or the cleaning tube; the second stopper is pushed by the second spring to close the catheter, reducing the contamination caused by possible seepage of reagents or serum.

[0028] Furthermore, in another embodiment, the magnet layer in the indicator rod is an electromagnet, the second stopper is a magnet block with a fixed magnetic pole direction, and a button switch for controlling the switching of the magnetic pole direction of the electromagnet is provided on the top of the indicator rod.

[0029] Beneficial effects: When the ball moves toward the top of the liquid guiding tube or the liquid guiding tube leaves the position of the ball, the magnetic pole direction of the electromagnet is controlled by the button switch so that the magnetic pole of the electromagnet near the contact surface is in the same direction as the magnet block, and the sealing of the liquid guiding tube is strengthened due to the repulsion of like magnetic poles; when the ball is located above the liquid guiding tube, the magnetic pole direction of the electromagnet is controlled by the button switch so that the magnetic pole of the electromagnet near the contact surface is opposite to the direction of the magnet block, and the second stopper is driven to move upward due to the attraction of opposite magnetic poles, so that the liquid guiding tube contacts the detection tube or the cleaning tube.

[0030] Furthermore, a plurality of heat-insulating layers are fixedly connected in the syringe, and the heat-insulating layers are located between adjacent installation cavities.

[0031] Beneficial effect: The thermal insulation layer is used to reduce the temperature interference between adjacent detection tubes or cleaning tubes to meet the phenomenon that different reagents are affected by external factors (such as temperature, humidity, light, etc.) and cause the activity of the reagents to decrease or become ineffective, thereby improving the accuracy of the test results.

[0032] Furthermore, the clamping mechanism includes a plurality of clamping blocks, a rotating shaft is fixedly connected at the center of the clamping block, a torsion spring is sleeved on the rotating shaft, and the clamping block is rotatably matched with the suction tube through the rotating shaft; a pull rod is provided at one end of the clamping block close to the syringe, a sleeve ring is slidably matched on the pull rod, the clamping block is hinged to the sleeve ring, and the clamping block is slidably matched with the pull rod through the sleeve ring;

[0033] An extension rod is provided at one end of the pull rod away from the clamping block, and the extension rod is slidably matched with the suction pipe along the movement direction of the piston, a third spring is provided between the bottom of the extension rod and the suction pipe, and the top of the extension block is located in the suction pipe; the end of the pull rod away from the clamping block is located below the extension rod, and a rotation point is provided at one quarter of the extension rod, and the pull rod is rotatably matched with the suction pipe around the rotation point;

[0034] When the piston is at the lowest point, the extension rod contacts the pull rod, and the clamping block opens; when the piston is at the highest point, the extension rod does not contact the pull rod, and the clamping block closes.

[0035] Beneficial effect: Through the movement of the piston, the piston and the extension rod come into contact. When the piston and the extension rod come into contact, the extension rod presses the pull rod, causing the pull rod to drive the top of the clamping block to rotate upward, thereby causing the clamping block to move outward away from one end of the pull rod, so that the clamping block loosens the fixation of the needle tube, facilitating the subsequent replacement of the needle tube.

[0036] When the piston moves upward, the piston no longer presses the extension rod. At this time, the compressed third spring releases the elastic force to push the extension rod to move upward. The extension rod no longer exerts pressure on the pull rod, and the clamping block is affected by the reset force of the torsion spring, causing the pull rod and the clamping block to reset, so that the clamping block clamps the needle tube and ensures stability during use.

[0037] Furthermore, a rubber sleeve seal is provided between the extension rod and the suction pipe, and a valve is provided at one end of the suction pipe close to the clamping block.

[0038] Beneficial effects: The rubber sleeve is used to increase the amount of serum that enters the extension rod during sliding, reducing residue and reducing mutual contamination. The inside of the suction tube is controlled by a valve to facilitate adjustment of the flow direction of serum in the suction tube during compression of the piston, so as to facilitate cleaning of the inside of the suction tube and reduce mutual interference when suctioning serum at different times.

[0039] Furthermore, a plurality of scale lines are engraved on the first rod, and a nut is threadedly connected to the first rod.

[0040] Beneficial effect: The nut is rotated on the first rod to confirm the descending height of the nut seat driven by the first rod, and the discharge volume of the syringe is determined through the indication of the nut on the first rod.

[0041] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Figure 1 It is an axonometric diagram of an embodiment of a liver cancer detection device for measuring liver epitope peptides of the present invention;

[0043] Figure 2 A bottom view of an embodiment of a liver cancer detection device for measuring liver epitope peptides according to the present invention;

[0044] Figure 3 A top view of an embodiment of a liver cancer detection device for measuring liver epitope peptides according to the present invention;

[0045] Figure 4 for Figure 3 Schematic diagram of the cross section along the AA direction;

[0046] Figure 5 for Figure 4 A magnified schematic diagram of the part B in the middle;

[0047] Figure 6 for Figure 4 A magnified schematic diagram of the local D in the middle;

[0048] Figure 7 for Figure 1 Schematic diagram of the cross section along the CC direction.

[0049] The figure marks in the drawings of the specification include: 1. syringe; 11. slide groove; 12. first stopper; 13. shielding chamber; 2. suction tube; 21. handle; 22. first rod; 23. piston; 24. nut; 3. mounting block; 31. mounting chamber; 32. one-way valve; 4. clamping block; 41. pull rod; 42. extension rod; 43. third spring; 44. collar; 5. indicator rod; 51. magnet layer; 52. ball; 6. catheter; 61. second stopper. DETAILED DESCRIPTION

[0050] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0051] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0052] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0053] The following is further described in detail through specific implementation methods:

[0054] Embodiment 1:

[0055] As attached Figures 1 to 7 As shown: a liver cancer detection device for liver epitope peptide determination, comprising a syringe 1, a suction tube 2 is rotatably matched in the syringe 1, a piston 23 is slidably matched in the suction tube 2, a first rod 22 is welded on the top of the piston 23, the first rod 22 is slidably matched with the suction tube 2, a handle 21 is welded on the end of the first rod 22 away from the suction tube 2, and a plurality of scale lines (not shown in the figure) are engraved on the first rod 22, and a nut 24 is threadedly connected on the first rod 22. A clamping mechanism for clamping the needle tube is provided at the bottom of the suction tube 2, and a valve (not shown in the figure) is provided at the end of the suction tube 2 close to the clamping mechanism.

[0056] The clamping mechanism includes a plurality of clamping blocks 4. The clamping block 4 is integrally formed with a conical clamping block (not shown in the figure) at one end away from the suction tube 2. A rotating shaft is welded at the center of the clamping block 4. A torsion spring (not shown in the figure) is sleeved on the rotating shaft. The clamping block 4 rotates with the suction tube 2 through the rotating shaft. A pull rod 41 is provided at one end of the clamping block 4 close to the syringe 1. A collar 44 is slidably fitted on the pull rod 41. The clamping block 4 is hinged to the collar 44. The clamping block 4 slides with the pull rod 41 through the collar 44.

[0057] An extension rod 42 is provided at the end of the pull rod 41 away from the clamping block 4, and a rubber sleeve seal is provided between the extension rod 42 and the suction pipe 2. The extension rod 42 slides with the suction pipe 2 along the movement direction of the piston 23. A third spring 43 is provided between the bottom of the extension rod 42 and the suction pipe 2, and the top of the extension block is located in the suction pipe 2; the end of the pull rod 41 away from the clamping block 4 is located below the extension rod 42, and a rotation point is provided at one quarter of the pull rod 41 near the extension rod 42, and the pull rod 41 rotates with the suction pipe 2 around the rotation point; when the piston 23 is at the lowest point, the extension rod 42 is against the pull rod 41, and the clamping block 4 is opened; when the piston 23 is at the highest point, the extension rod 42 is not in contact with the pull rod 41, and the clamping block 4 is closed.

[0058] The syringe 1 is also provided with a plurality of mounting blocks 3, in which mounting blocks 3 are provided mounting cavities 31, which are connected to one-way valves 32, and in which mounting blocks 3 are bonded a plurality of heat-insulating layers, which are located between adjacent mounting cavities 31; the mounting blocks 3 are arranged in a ring shape with the suction tube 2 as the center, and detection tubes and cleaning tubes are respectively provided in the mounting cavities 31, and the cleaning tubes are located between adjacent detection tubes; the suction tube 2 is connected with a liquid guide tube 6, and the suction tube 2 is respectively connected with the cleaning tube or the detection tube through the liquid guide tube 6 and the one-way valve 32.

[0059] It also includes an indicating mechanism, which includes an annular shielding cavity 13 opened on the syringe 1, and the shielding cavity 13 is connected to the installation cavity 31 through a one-way valve 32; and the top of the shielding cavity 13 is also connected to a plurality of slide grooves 11, and the slide grooves 11 correspond to the positions of the detection tube or the cleaning tube, and an indicating rod 5 is slidably fitted in the slide groove 11, and a ball 52 is hinged at the bottom of the indicating rod 5, and the ball 52 is located in the shielding cavity 13; and the liquid guide tube 6 is gap-fitted with the shielding cavity 13; when the liquid guide tube 6 contacts the ball 52, the ball 52 is located above the shielding cavity 13, and the liquid guide tube 6 is connected to the cleaning tube or the detection tube; when the liquid guide tube 6 is separated from the ball 52, the ball 52 is located in the shielding cavity 13, and the liquid guide tube 6 is separated from the cleaning tube or the detection tube.

[0060] A magnet layer 51 is clamped in the indicating rod 5, and a clamping cavity is slidably fitted in the syringe 1. The position of the clamping cavity corresponds to the position of the shielding cavity 13, and a first stopper 12 is slidably fitted in the clamping cavity, and a first spring is provided between the top of the first stopper 12 and the syringe 1; a second stopper 61 is slidably fitted in the catheter tube 6, and both the first stopper 12 and the second stopper 61 are magnetic bodies driven by the suction force of the magnet, and a second spring is provided between the top of the second stopper 61 and the catheter tube 6; when the catheter tube 6 contacts the ball 52, the first stopper 12 opens the detection tube or the cleaning tube, and the second stopper 61 opens the catheter tube 6; when the catheter tube 6 separates from the ball 52, the first stopper 12 closes the detection tube or the cleaning tube, and the second stopper 61 closes the catheter tube 6.

[0061] The specific implementation process is as follows: during use, the detection tube and the cleaning tube are first installed in the installation cavity 31 in an alternating arrangement order, so that the detection tube and the cleaning tube are connected to the one-way valve 32.

[0062] Before use, the handle 21 is manually held to drive the first rod 22 to push the piston 23 to move, so that the piston 23 is located at the lowest point of the suction tube 2, and the piston 23 contacts the extension rod 42. At this time, there is no liquid in the suction tube 2, and the extension rod 42 presses the pull rod 41 to make the pull rod 41 rotate around the rotation point and drive the top of the clamping block 4 to rotate upward. The sleeve on the pull rod 41 slides to ensure that the clamping block 4 rotates around the rotating axis, so that the end of the clamping block 4 away from the pull rod 41 moves outward, so that the clamping block 4 loosens the fixation on the needle tube to facilitate the replacement of the needle tube.

[0063] The handle 21 is manually held to drive the first rod 22 to push the piston 23 to move upward, so that the piston 23 no longer presses the extension rod 42. At this time, the compressed third spring 43 releases the elastic force to push the extension rod 42 to move upward, and the extension rod 42 no longer exerts pressure on the pull rod 41. The clamping block 4 is affected by the reset force of the torsion spring, so that the pull rod 41 and the clamping block 4 are reset, so that the clamping block 4 clamps and fixes the needle tube to ensure stability during use.

[0064] The needle tube is manually brought into contact with the serum to be drawn, and the handle 21 is continued to drive the first rod 22 to push the piston 23 to move, and the amount of serum drawn is determined by the scale line on the first rod 22. After the drawing is completed, the rotating nut 24 is rotated on the first rod 22, and the nut 24 is used to limit the descending height of the nut 24 seat driven by the first rod 22.

[0065] Then, by rotating the suction tube 2, the liquid guide tube 6 is made to slide in the shielding cavity 13, so that the liquid guide tube 6 pushes the ball 52 to push the indicator rod 5 out of the syringe 1, and the extension indication of the indicator rod 5 in different directions is used to determine the connection status of the liquid guide tube 6 with different detection tubes or cleaning tubes, thereby facilitating the reaction of the serum with the reagents in different detection tubes.

[0066] At the same time, during the sliding of the liquid guiding tube 6, when the ball 52 is located above the liquid guiding tube 6, the magnetic force of the first stopper 12 is adsorbed by the magnet layer 51 to drive the first stopper 12 to move upward, so that the position of the detection tube or the cleaning tube is leaked. At the same time, the ball 52 adsorbs the second stopper 61 through the magnet layer 51 to drive the second stopper 61 to move upward, so that the position of the liquid guiding tube 6 is leaked, thereby ensuring the connection between the liquid guiding tube 6 and the detection tube or the cleaning tube.

[0067] When the catheter 6 leaves the position of the ball 52, the indicator rod 5 falls naturally due to the influence of gravity, so that the ball 52 is located in the shielding cavity 13, and the first stopper 12 is pushed by the magnetic layer 51 and the compressed spring to close the position of the detection tube or the cleaning tube; the second stopper 61 is pushed by the second spring to close the catheter 6, thereby reducing the contamination caused by the possible leakage of reagents or serum.

[0068] At the same time, through the alternating arrangement of detection tubes and cleaning tubes, after the serum and reagent are mixed, the cleaning tubes can be connected in time for flushing. Compared with the separation and cleaning of the prior art, the processing steps are reduced, the cleaning efficiency is guaranteed, and the interference and contamination of different sera are reduced, so as to realize the continuous detection of different markers.

[0069] Embodiment 2:

[0070] The difference from the first embodiment is that the magnet layer 51 in the indicator rod 5 is an electromagnet, the second stopper 61 is a magnet block with a fixed magnetic pole direction, and a button switch for controlling the switching of the magnetic pole direction of the electromagnet is provided on the top of the indicator rod 5.

[0071] The specific implementation process is as follows: when the ball 52 moves toward the top of the liquid guiding tube 6 or when the liquid guiding tube 6 leaves the position of the ball 52, the magnetic pole direction of the electromagnet is controlled by the button switch so that the magnetic pole of the electromagnet near the contact surface is in the same direction as the magnet block, and under the influence of the repulsion of like magnetic poles, the sealing of the liquid guiding tube 6 is strengthened; when the ball 52 is located above the liquid guiding tube 6, the magnetic pole direction of the electromagnet is controlled by the button switch so that the magnetic pole of the electromagnet near the contact surface is opposite to the magnet block, and under the influence of the attraction of opposite magnetic poles, the second stopper 61 is driven to move upward, so that the liquid guiding tube 6 contacts the detection tube or the cleaning tube.

[0072] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A liver cancer detection device for measuring liver epitope peptides, characterized in that: It comprises a syringe (1), a suction tube (2) rotatably fitted inside the syringe (1), a piston (23) slidably fitted inside the suction tube (2), and a clamping mechanism for clamping the syringe is provided at the bottom of the suction tube (2); The syringe (1) is also provided with a plurality of mounting blocks (3), each of which is provided with a mounting cavity (31), which is connected to a one-way valve (32); the mounting blocks (3) are arranged in a ring shape with the suction tube (2) as the center, and a detection tube and a cleaning tube are respectively provided in the mounting cavity (31), and the cleaning tube is located between adjacent detection tubes; the suction tube (2) is connected to a liquid guide tube (6), and the suction tube (2) is connected to the cleaning tube or the detection tube through the liquid guide tube (6) and the one-way valve (32).

2. The liver cancer detection device for measuring liver epitope peptides according to claim 1, characterized in that: The top of the piston (23) is fixedly connected to a first rod (22), the first rod (22) is slidably matched with the suction pipe (2), and one end of the first rod (22) away from the suction pipe (2) is fixedly connected to a handle (21).

3. The liver cancer detection device for measuring liver epitope peptides according to claim 2, characterized in that: One end of the clamping block (4) away from the suction pipe (2) is fixedly connected with a conical clamping block.

4. The liver cancer detection device for measuring liver epitope peptides according to claim 3, characterized in that: The device also comprises an indicating mechanism, which comprises an annular shielding cavity (13) opened on the syringe (1), the shielding cavity (13) being connected to the installation cavity (31) via a one-way valve (32); and the top of the shielding cavity (13) is also connected to a plurality of slide grooves (11), the slide grooves (11) corresponding to the positions of the detection tube or the cleaning tube, an indicating rod (5) slidably fitted in the slide groove (11), a ball bearing (52) being hinged at the bottom of the indicating rod (5), and the ball bearing (52) being located in the shielding cavity (13); and the liquid guiding tube (6) is clearance-fitted with the shielding cavity (13); When the liquid guiding tube (6) is in contact with the ball (52), the ball (52) is located above the shielding cavity (13), and the liquid guiding tube (6) is connected to the cleaning tube or the detection tube; when the liquid guiding tube (6) is separated from the ball (52), the ball (52) is located in the shielding cavity (13), and the liquid guiding tube (6) is separated from the cleaning tube or the detection tube.

5. The liver cancer detection device for measuring liver epitope peptides according to claim 4, characterized in that: A magnet layer (51) is fixedly connected inside the indicator rod (5), and a locking cavity is slidably matched inside the syringe (1), the position of the locking cavity corresponds to the position of the shielding cavity (13), and a first stopper (12) is slidably matched inside the locking cavity, and a first spring is provided between the top of the first stopper (12) and the syringe (1); A second stopper (61) is slidably fitted inside the liquid guiding tube (6); both the first stopper (12) and the second stopper (61) are magnetic bodies driven by the attraction of a magnet; and a second spring is provided between the top of the second stopper (61) and the liquid guiding tube (6); When the liquid guiding tube (6) contacts the ball (52), the first stopper (12) opens the detection tube or the cleaning tube, and the second stopper (61) opens the liquid guiding tube (6); when the liquid guiding tube (6) separates from the ball (52), the first stopper (12) closes the detection tube or the cleaning tube, and the second stopper (61) closes the liquid guiding tube (6).

6. The liver cancer detection device for measuring liver epitope peptides according to claim 5, characterized in that: The magnet layer (51) in the indicator rod (5) is an electromagnet, the second stopper (61) is a magnet block with a fixed magnetic pole direction, and a button switch for controlling the switching of the magnetic pole direction of the electromagnet is provided on the top of the indicator rod (5).

7. The liver cancer detection device for measuring liver epitope peptides according to claim 6, characterized in that: A plurality of heat insulation layers are also fixedly connected inside the syringe (1), and the heat insulation layers are located between adjacent installation cavities (31).

8. The liver cancer detection device for measuring liver epitope peptides according to claim 7, characterized in that: The clamping mechanism comprises a plurality of clamping blocks (4), a rotating shaft is fixedly connected at the center of the clamping block (4), a torsion spring is sleeved on the rotating shaft, and the clamping block (4) is rotatably matched with the suction tube (2) through the rotating shaft; a pull rod (41) is provided at one end of the clamping block (4) close to the syringe (1), a sleeve ring (44) is slidably matched on the pull rod (41), the clamping block (4) and the sleeve ring (44) are hinged, and the clamping block (4) is slidably matched with the pull rod (41) through the sleeve ring (44); An extension rod (42) is provided at one end of the pull rod (41) away from the clamping block (4), and the extension rod (42) is slidably matched with the suction pipe (2) along the movement direction of the piston (23). A third spring (43) is provided between the bottom of the extension rod (42) and the suction pipe (2), and the top of the extension block is located in the suction pipe (2); the end of the pull rod (41) away from the clamping block (4) is located below the extension rod (42), and a rotation point is provided at one quarter of the pull rod (41) near the extension rod (42), and the pull rod (41) is rotationally matched with the suction pipe (2) with the rotation point as the center; When the piston (23) is at the lowest point, the extension rod (42) abuts against the pull rod (41), and the clamping block (4) opens; when the piston (23) is at the highest point, the extension rod (42) does not contact the pull rod (41), and the clamping block (4) closes.

9. The liver cancer detection device for measuring liver epitope peptides according to claim 8, characterized in that: A rubber sleeve seal is provided between the extension rod (42) and the suction pipe (2), and a valve is provided at one end of the suction pipe (2) close to the clamping block (4).

10. The liver cancer detection device for measuring liver epitope peptides according to claim 9, characterized in that: A plurality of scale lines are engraved on the first rod (22), and a nut (24) is threadedly connected to the first rod (22).

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