Preparation method and use method of temperature change antibacterial hand sanitizer

Abstract

The invention discloses a preparation method and a use method of a temperature change bacteriostatic hand sanitizer. The temperature change bacteriostatic hand sanitizer is prepared from the following components in parts by mass: a compound surfactant, a thickening agent, a humectant, a bacteriostatic agent, temperature change color powder and the balance of water. The technical problem to be solved by the invention is to provide the thermochromic bacteriostatic hand sanitizer, the cleaning degree can be intuitively reflected and the bacteriostatic effect can be provided according to rubbing time and observation of foam color change in the use process, the thermochromic powder is added into the hand sanitizer for the first time, and the thermochromic powder is mixed with the bacteriostatic liquid for use, so that the stability of the thermochromic powder is effectively improved; the temperature-sensing color-changing antibacterial hand sanitizer capable of monitoring the hand washing time of children is provided through matched use.

Description

Technical Field

[0001] The invention belongs to the field of hand sanitizer, and in particular relates to a preparation method and a use method of a temperature-variable antibacterial hand sanitizer. Background Art

[0002] Hand sanitizer is a skin care cleansing liquid used to clean hands. It removes dirt and attached bacteria on hands through mechanical friction and the action of surfactants, with or without water. After three years of epidemic prevention and control, people's awareness of daily disinfection and protection has gradually increased, and the scale of my country's hand sanitizer market has experienced rapid growth.

[0003] People's demand for hand sanitizer functions is also increasing due to the growth of the market scale. In recent years, the three most concerned functions are children's use, antibacterial, and no-wash. However, the existing hand sanitizers have not been recorded or reported on how to intuitively reflect whether children's hands are fully scrubbed and cleaned through the color change of hand sanitizer. For example, the invention patent with the authorization announcement number CN111658571B discloses a disinfectant hand sanitizer, the raw materials of which include 2-8% sodium N-lauroyl sarcosine; 4-12% sodium dodecyl sulfate; 2-8% dodecyl glucoside; 0.2-1.2% silver-containing composite antibacterial agent; the balance is water, and the silver composite antibacterial agent is used to achieve the antibacterial effect, which improves the antibacterial function of the hand sanitizer, but it cannot be intuitively felt by the user. Summary of the invention

[0004] In view of the deficiencies in the prior art, the object of the present invention is to provide a preparation method and a use method of a temperature-dependent antibacterial hand sanitizer.

[0005] The technical solution of the present invention is summarized as follows:

[0006] A temperature-dependent antibacterial hand sanitizer, comprising the following components and their mass percentages:

[0007] Compound surfactant 9% to 30%;

[0008] Thickener 1.5-2.5%;

[0009] Moisturizer 5.5-9.5%;

[0010] Antibacterial agent 0.4-1.1%;

[0011] Thermochromic powder 0.5-2.5%;

[0012] The balance is water;

[0013] The compound surfactant is a combination of a nonionic surfactant and an anionic surfactant, which can produce a synergistic effect and reduce the irritation of the surfactant.

[0014] The thermochromic powder is a food-grade 40-degree thermochromic powder with a color-changing temperature between 35 and 40°C. It is red when the temperature is below 35°C and white when the temperature is between 35 and 40°C. The thermochromic powder contains a color-changing substance and a transparent capsule shell about 0.2 to 0.5 microns thick that is neither soluble nor melted, protecting the thermochromic powder from the influence of chemicals.

[0015] The antibacterial agent is cinnamaldehyde, which has an antibacterial effect on Escherichia coli and Staphylococcus aureus and has reducing properties, which can effectively slow down the oxidation speed of the temperature-changing color powder.

[0016] A method for preparing a temperature-dependent antibacterial hand sanitizer comprises the following steps:

[0017] At 80-90° C., 9%-30% of a composite surfactant is added into water and stirred for 30-60 minutes until it is completely dissolved, and then 5.5-9.5% of a moisturizer, 1.5-2.5% of a thickener, and 5-11% of a thermochromic color powder are added in sequence while maintaining the temperature, and stirred for 1-1.5 hours. The temperature is lowered to 30-40° C., and stirred for 1-2 hours to obtain the thermochromic hand sanitizer.

[0018] Preferably, the nonionic surfactant in the compound surfactant is prepared by mixing fatty alcohol polyoxyethylene ether and deoxynyl glucoside in a ratio of 1: (0.3-0.4).

[0019] Preferably, the nonionic surfactant in the composite surfactant is prepared by mixing sodium lauryl glucose carboxylate, potassium cocoyl glycinate and sodium fatty alcohol polyoxyethylene ether sulfate in a ratio of 1:(0.6-0.8):(0.3-0.4).

[0020] Preferably, the thickener is sodium chloride or carbomer.

[0021] Preferably, the moisturizing agent is a mixture of glycerol, ethoxylated glyceride, and PEG-7 glyceryl cocoate in a ratio of 1:(0.3-0.5):(0.6-0.9).

[0022] On the other hand, the present invention also provides a method for using the temperature-changing hand sanitizer:

[0023] First, moisten your hands thoroughly with clean water, take an appropriate amount of hand sanitizer and rub your hands thoroughly on the palms for at least 30 seconds to produce foam. The temperature of your hands will rise from about 31-33℃ to 35-37℃ as you rub. The foam will turn from red to white, indicating that you have washed your hands thoroughly. Rinse with running water after rubbing.

[0024] Beneficial Effects of the Invention

[0025] The present invention provides a temperature-variable antibacterial hand washing liquid, which utilizes the rubbing during hand washing and the micro-particle characteristics of the temperature-variable color powder to increase the friction during hand washing and increase the temperature. The hand washing liquid changes color according to temperature, so as to monitor whether the children wash their hands thoroughly. The antibacterial property of cinnamaldehyde is utilized to provide a good bactericidal effect. At the same time, the inventor unexpectedly finds that the reducing property of cinnamaldehyde can effectively prevent the temperature-variable color powder from oxidizing. Specific embodiments

[0026] The present invention is further described in detail below in conjunction with embodiments so that those skilled in the art can implement the invention with reference to the description.

[0027] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are only examples, and those skilled in the art can think of other obvious variations. The basic principles of the present invention defined in the following description can be applied to other embodiments, variations, improvements, equivalents, and other technical solutions that do not deviate from the spirit and scope of the present invention.

[0028] A method for synthesizing a temperature-changing hand sanitizer comprises the following components:

[0029]

[0030] Example 1

[0031] A temperature-dependent antibacterial hand sanitizer, the hand sanitizer comprising the following components:

[0032]

[0033]

[0034] A method for preparing a temperature-dependent antibacterial hand sanitizer comprises the following steps:

[0035] At 80-90°C, 40g of fatty alcohol polyoxyethylene ether, 20g of demeryl glucoside, 7.5g of sodium lauryl glucose carboxylate, 7.5g of potassium cocoyl glycinate and 10g of sodium fatty alcohol polyoxyethylene ether sulfate are added into water and stirred for 40 minutes. After they are completely dissolved, 17.5g of glycerol, 10g of ethoxylated glyceride, 7.5g of PEG-7 glyceryl cocoate and 10g of sodium chloride are added in sequence and stirred for 1 hour while maintaining the temperature. After the temperature is lowered to 30-40°C, 3.5g of cinnamaldehyde and 7.5g of temperature-changing color powder are added and stirred for 1.5 hours to obtain the temperature-changing antibacterial hand soap.

[0036] Example 2

[0037] A temperature-dependent antibacterial hand sanitizer, the hand sanitizer comprising the following components:

[0038]

[0039] A method for preparing a temperature-dependent antibacterial hand sanitizer comprises the following steps:

[0040] At 80-90°C, 60g of fatty alcohol polyoxyethylene ether, 40g of demeryl glucoside, 10g of sodium lauryl glucose carboxylate, 10g of potassium cocoyl glycinate and 7.5g of sodium polyoxyethylene fatty alcohol ether sulfate are added into water and stirred for 60 minutes. After they are completely dissolved, 20g of glycerol, 7.5g of ethoxylated glycerides, 5g of PEG-7 glyceryl cocoate and 7.5g of sodium chloride are added in sequence and stirred for 1 hour while maintaining the temperature. After the temperature is lowered to 30-40°C, 5g of cinnamaldehyde and 5g of temperature-changing color powder are added and stirred for 2 hours to obtain the temperature-changing antibacterial hand sanitizer.

[0041] Example 3

[0042] A temperature-dependent antibacterial hand sanitizer, the hand sanitizer comprising the following components:

[0043]

[0044] A method for preparing a temperature-dependent antibacterial hand sanitizer comprises the following steps:

[0045] At 80-90°C, 30g of fatty alcohol polyoxyethylene ether, 25g of demeryl glucoside, 5g of sodium lauryl glucose carboxylate, 5g of potassium cocoyl glycinate and 10g of sodium fatty alcohol polyoxyethylene ether sulfate are added into water and stirred for 30 minutes. After they are completely dissolved, 20g of glycerol, 5g of ethoxylated glyceride, 7.5g of PEG-7 glyceryl cocoate and 7.5g of sodium chloride are added in sequence and stirred for 1 hour while maintaining the temperature. After the temperature is lowered to 30-40°C, 5g of cinnamaldehyde and 5g of temperature-changing color powder are added and stirred for 1 hour, the temperature-changing antibacterial hand soap is obtained.

[0046] Comparative Example 1 is the same as Example 1, except that: cinnamaldehyde is not added in Comparative Example 1, specifically: at 80-90°C, 30g of fatty alcohol polyoxyethylene ether, 25g of decyl glucoside, 5g of sodium lauryl glucose carboxylate, 5g of potassium cocoyl glycinate and 10g of sodium fatty alcohol polyoxyethylene ether sulfate are added to water and stirred for 30 minutes. After complete dissolution, 20g of glycerol, 5g of ethoxylated glyceride, 7.5g of PEG-7 glyceryl cocoate and 7.5g of sodium chloride are added in sequence and stirred for 1 hour while maintaining the temperature. After cooling to 30-40°C, 5g of temperature-changing color powder is added and stirred for 1 hour to obtain the temperature-changing antibacterial hand sanitizer.

[0047] Comparative Example 2 is the same as Example 2, except that: no temperature-changing color powder is added in Comparative Example 2, specifically: at 80-90°C, 60g of fatty alcohol polyoxyethylene ether, 40g of demerara glucoside, 10g of sodium lauryl glucose carboxylate, 10g of potassium cocoyl glycinate and 7.5g of sodium sulfate of fatty alcohol polyoxyethylene ether are added to water and stirred for 60 minutes. After complete dissolution, 20g of glycerol, 7.5g of ethoxylated glyceride, 5g of PEG-7 glyceryl cocoate and 7.5g of sodium chloride are added in sequence at a temperature maintained and stirred for 1 hour. After cooling to 30-40°C, 5g of cinnamaldehyde is added and treated for 2 hours to obtain the temperature-changing antibacterial hand sanitizer.

[0048] With reference to the industry standard QB / T2850-2007 antibacterial and antimicrobial detergent, the hand sanitizers of Examples 1-3 were tested for their antibacterial effects. In the antibacterial test, the concentration was 1:100 and the action time was 20 minutes. Specific test data are shown in Table 1 below.

[0049] Table 1: Antibacterial effect test table

[0050] Antibacterial rate, % (Escherichia coli ATCC25922) Example 1 81.2 Example 2 85.6 Example 3 90.5 Comparative Example 2 86.5

[0051] Comparative Example 2 is a temperature-dependent antibacterial hand sanitizer prepared in Example 2, except that the temperature-dependent color powder is reduced. It can be seen that the mixture of the temperature-dependent color powder and cinnamaldehyde improves the bactericidal ability.

[0052] A color change test was performed on Examples 1-3 and Comparative Example 1: first, thoroughly moisten both hands with clean water, take an appropriate amount of hand sanitizer and rub both hands in the palms to produce foam, and observe the color change effect, color change time and color change time after being left open for 10 days.

[0053]

[0054] Comparative Example 1 is a temperature-dependent antibacterial hand sanitizer prepared in Example 1, but cinnamaldehyde is reduced. It can be seen that after the temperature-dependent color powder is mixed with cinnamaldehyde, the reducing property of cinnamaldehyde is used to effectively prevent the temperature-dependent color powder from being oxidized.

Claims

1. A temperature-dependent antibacterial hand sanitizer, characterized in that: Includes the following components and their mass percentages: Compound surfactant 9% to 30%; Thickener 1.5-2.5%; Moisturizer 5.5-9.5%; Antibacterial agent 0.4-1.1%; Thermochromic powder 0.5-2.5%; The balance is water; The thermochromic powder is a food grade 40 degree thermochromic powder with a color changing temperature between 35 and 40°C. It is red when the temperature is below 35°C and white when the temperature is between 35 and 40°C. The thermochromic powder contains a color changing substance inside and a transparent capsule shell about 0.2 to 0.5 microns thick that is neither soluble nor meltable, protecting the internal thermochromic powder from the influence of chemicals.

2. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The preparation method of the temperature-dependent antibacterial hand sanitizer is as follows: adding 9% to 30% of a composite surfactant into water at 80 to 90° C. and stirring for 30 to 60 minutes until the surfactant is completely dissolved, then adding 5.5 to 9.5% of a moisturizer, 1.5 to 2.5% of a thickener, and 5 to 11% of a color powder in sequence while maintaining the temperature, stirring for 1 to 1.5 hours, cooling the temperature to 30 to 40° C. and stirring for 1 to 2 hours to obtain the temperature-dependent hand sanitizer.

3. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The compound surfactant is a combination of a nonionic surfactant and an anionic surfactant, which can produce a synergistic effect and reduce the irritation of the surfactant.

4. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The nonionic surfactant in the compound surfactant is prepared by mixing fatty alcohol polyoxyethylene ether and deoxynyl glucoside in a ratio of 1: (0.3-0.4).

5. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The nonionic surfactant in the composite surfactant is prepared by mixing sodium lauryl glucose carboxylate, potassium cocoyl glycinate and sodium fatty alcohol polyoxyethylene ether sulfate in a ratio of 1:(0.6-0.8):(0.3-0.4).

6. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The antibacterial agent is cinnamaldehyde.

7. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The thickener is one of sodium chloride or carbomer.

8. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The moisturizing agent is prepared by mixing glycerin, ethoxylated glyceride and PEG-7 glyceryl cocoate in a ratio of 1:(0.3-0.5):(0.6-0.9).

9. A temperature-dependent antibacterial hand sanitizer according to claim 1, characterized in that: The method of using the temperature-dependent antibacterial hand sanitizer is as follows: first, fully moisten both hands with clean water, take an appropriate amount of hand sanitizer and rub both hands in the palms for at least 30 seconds to produce foam. The hand temperature rises from about 31 to 33° C. to 35 to 37° C. as the hand is rubbed, and the foam changes from red to white, indicating that the hand is fully rubbed. After rubbing, rinse with running water.

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