Medicinal and edible plant composition with liver protection function and application thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compounds, in particular to a medicinal and edible plant composition with a liver protection function, which is prepared from the following components in parts by mass: 13 to 20 parts of fructus lycii, 15 to 20 parts of semen cassiae, 10 to 15 parts of fructus gardeniae, 10 to 15 parts of radix angelicae sinensis, 6 to 15 parts of folium cortex eucommiae, 7 to 13 parts of fructus citri sarcodactylis, 6 to 10 parts of flos lablab album and 10 to 15 parts of poria cocos. From the whole, the traditional Chinese medicine composition provided by the invention not only protects the liver, but also gives consideration to compatibility innovation of medicine properties, applies the traditional Chinese medicine dialectical theory, and pays attention to the use experience of a user at the same time. Through a multi-factor and multi-path synergistic effect, the advantages of nourishing and protecting the liver and regulating the whole body are achieved, and the overall control advantage is also the main innovation point of the invention. The traditional Chinese medicines are comprehensively applied, so that the physical condition of a user can be better adjusted, the treatment effect is improved, healthy life assistance is provided for the user, and a new way is provided for prevention and treatment of liver injury by virtue of the characteristics and advantages of the traditional Chinese medicines.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine compound prescriptions, and in particular to a medicinal and edible plant composition with liver protection function and application thereof. Background Art

[0002] As an important functional organ of the human body, the liver plays an important physiological role in synthesis, metabolism, detoxification and immunity. As the liver participates in a variety of physiological activities, it is also susceptible to damage, and these injuries gradually accumulate with the continuous action of the cause, and may eventually develop into irreversible damage such as cirrhosis and liver cancer. Nowadays, the main causes of liver damage include obesity, alcohol, irregular living habits, etc.

[0003] Fatty liver is an important cause of liver damage. Fatty liver can be divided into alcoholic fatty liver and non-alcoholic fatty liver, and the occurrence of non-alcoholic fatty liver is closely related to obesity. According to the BMI classification standard, that is, weight divided by the square of height, values ​​of 24 to 27.9 are overweight, and greater than 27.9 are obese. According to the results of a sample survey of 15.8 million adults in my country, 34.8% of the population is overweight and 14.1% is obese. Early fatty liver disease can be reversed, but it cannot be reversed in the stage of severe fatty hepatitis. The occurrence of fatty liver is related to metabolic disorders, and there is no specific drug for the treatment of fatty liver so far. In addition, excessive drinking is also an important factor causing liver damage. Alcohol directly damages the liver cell membrane and mitochondria through its metabolite acetaldehyde and the reactive oxygen produced in the middle, resulting in damage to the structure and function of liver cells. It will eventually cause alcoholic hepatitis and can develop into alcoholic cirrhosis and liver cancer. In addition to the above factors, the irregular lifestyle of modern people may be becoming an important factor affecting liver health, including staying up late, excessive fatigue, emotional distress, and irregular diet. Staying up late for a long time, lack of sleep, and decreased body resistance will affect the liver's self-repair at night and lead to toxin accumulation. In addition, irregular diet can also lead to poor bile secretion, which may cause bile stasis and damage the liver.

[0004] In view of the common living habits that cause liver damage in the current population, it is very beneficial and feasible to nourish and protect the liver by drawing on the theory of traditional Chinese medicine. According to the theory of traditional Chinese medicine, the liver is responsible for dredging, being happy and uneasy, and regulating the qi of the whole body. Stagnation of liver qi can cause chest tightness and phlegm due to qi stagnation. In addition, liver fire inflammation can cause headaches, dizziness, red face and eyes, and a feeling of dry throat and bitter mouth. Liver damage can also cause liver yin deficiency and qi and blood deficiency, which can cause numbness of limbs, dry eyes, blurred vision, and may also cause hot flashes and night sweats. At the same time, the liver and gallbladder are closely related. Liver damage can cause damp heat accumulation, flank pain, and vulvar itching. Therefore, according to the theory of traditional Chinese medicine, the liver is maintained on the one hand to regulate the qi of the liver and promote the elimination of toxic substances. On the other hand, it is to reconcile liver yang and calm liver wind. At the same time, combined with the research of modern medicine, Chinese medicine with anti-inflammatory and antioxidant properties is selected for auxiliary regulation to maintain the liver in an all-round way. By selecting Chinese herbal ingredients that are both medicinal and edible, and by long-term liver protection and conditioning, timely intervention in the early stages of liver damage, especially when exposed to risk factors, can effectively protect the liver and prevent damage from progressing. At the same time, it can also serve as an auxiliary treatment for liver damage that has already occurred. Summary of the invention

[0005] The purpose of the present invention is to provide a medicinal and edible plant composition with liver protection function to solve the above technical problems and improve the health level of the population.

[0006] In the first aspect, to achieve the above-mentioned purpose, the present invention provides a medicinal and edible plant composition with liver protection function, comprising the following components by mass: 13-20 parts of wolfberry, 15-20 parts of cassia seed, 10-15 parts of gardenia, 10-15 parts of angelica, 6-15 parts of eucommia leaves, 7-13 parts of citron, 6-10 parts of white labiatae flowers, and 10-15 parts of poria.

[0007] Preferably, the following raw materials are included in parts by weight: 15 parts of wolfberry, 15 parts of cassia seed, 15 parts of gardenia, 15 parts of angelica, 10 parts of eucommia leaves, 10 parts of bergamot, 10 parts of white hyacinth bean flowers, and 10 parts of poria.

[0008] Preferably, the following raw materials are included in parts by weight: 14 parts of wolfberry, 20 parts of cassia seed, 14 parts of gardenia, 14 parts of angelica, 6 parts of eucommia leaves, 14 parts of bergamot, 6 parts of white hyacinth bean flowers, and 12 parts of poria.

[0009] Preferably, the following raw materials are included in parts by weight: 16 parts of wolfberry, 14 parts of cassia seed, 12 parts of gardenia, 12 parts of angelica, 15 parts of eucommia leaves, 8 parts of bergamot, 8 parts of white hyacinth bean flower, and 15 parts of poria.

[0010] In a second aspect, the present invention provides the use of the above-mentioned medicinal and edible plant composition in protecting the liver.

[0011] The present invention has the advantages that:

[0012] 1. The invention is innovative in the four properties and five flavors of traditional Chinese medicine, the main curative effects and the combination of monarch, minister, assistant and envoy, and combines the research on drug efficacy of modern medicine:

[0013] Lycium barbarum: It is mild, sweet, and belongs to the liver and kidney meridians. It can nourish the liver and kidneys, improve the essence and eyesight. "Shennong's Herbal Classic" says that "long-term use can strengthen the bones and muscles, lighten the body and prevent aging, and resist cold and heat." Through its characteristics of belonging to the liver meridian, it can nourish liver damage. At the same time, the kidney is the foundation of innateness. Lycium barbarum can nourish the liver and kidneys, regulate the body constitution, and nourish the liver yin. Modern medical research results show that Lycium barbarum contains Lycium barbarum polysaccharides, Lycium barbarum total flavonoids, betaine, carotenoids, multiple vitamins, amino acids, trace elements and other active ingredients. These active ingredients give Lycium barbarum the effects of immune regulation, promoting tumor cell apoptosis, anti-oxidation, anti-radiation damage, lowering blood pressure, lowering blood sugar, regulating blood lipids, and protecting the liver.

[0014] Cassia seed: slightly cold, sweet, bitter, and salty, it belongs to the large intestine and liver meridians, and has the functions of soothing the liver and promoting gallbladder, clearing away heat and improving eyesight, and moistening the intestines and relieving constipation. It tastes bitter, can dry dampness and purge fire, vent liver fire, and at the same time relieve red eyes and dizziness caused by liver fire. Modern research shows that Cassia seed water-soluble substances have a protective effect on acute liver damage, and its mechanism of action is related to antioxidant. In addition, Cassia seed total anthraquinone, as the main active ingredient of Cassia seed, has a protective effect on immune liver damage, and its mechanism is related to anti-inflammatory and regulating the proportion of T lymphocyte subsets. Cassia seed also has the function of lowering blood lipids, regulating blood lipid metabolism, and has a positive effect on preventing fatty liver.

[0015] Gardenia: cold, bitter, enters the heart, lung, and triple burner meridians, can purge fire and relieve restlessness, clear away heat and dampness, cool blood and detoxify. The bitter and cold characteristics of gardenia can relieve liver yang, clear away heat and detoxify, and can also relieve irritability and restlessness caused by heat entering the pericardium. Modern pharmacological studies have shown that gardenia contains active ingredients such as gardenia glycoside, ursolic acid, geniposide, crocin, etc., which have multiple pharmacological effects such as lowering blood sugar, anti-atherosclerosis, anti-depression, liver protection and choleretic, anti-tumor, antibacterial, and protective effects on nerves. The anti-depressant properties of gardenia can also help to dredge the internal Qi and further enhance the protective effect of the liver.

[0016] Angelica: warm, sweet, pungent, enters the liver, heart, spleen meridians, can nourish blood, regulate menstruation and relieve pain, moisten the intestines and promote bowel movements. Modern medical research has confirmed that Angelica can also promote bone marrow hematopoiesis, promote hemoglobin and red blood cell production, have a bidirectional regulatory effect on the uterus, enhance immune function, improve peripheral circulation, lower blood pressure, resist oxidation, inhibit liver cholesterol synthesis, lower blood lipids, protect the liver, relieve pain, and calm the nerves. Angelica polysaccharide, the main active ingredient in Angelica, has a lipid-lowering effect on non-alcoholic fatty liver disease, can reduce lipid content, inhibit fat regeneration, improve liver lipid degeneration, and can be used as a therapeutic drug for non-alcoholic fatty liver disease. In addition, Angelica polysaccharide can also remove excessive free radicals, delay or prevent oxidation, and resist liver oxidative stress damage. At the same time, Angelica can also enhance the body's function, and its blood-tonifying characteristics can relieve liver blood deficiency caused by liver damage.

[0017] Eucommia leaves: warm, slightly spicy, enter the liver and kidney meridians, can nourish the liver and kidney, and strengthen the bones and muscles. Eucommia leaves mainly contain a variety of chemical components such as iridoids, lignans, flavonoids, phenylpropanoids, polysaccharides, organic acids, polyphenols and amino acids, which have the effects of lowering blood pressure, anti-inflammatory, enhancing immune function, sedation, analgesia, and promoting fracture healing. As a tonic medicine, Eucommia can nourish the liver and promote the self-repair of the liver. At the same time, its anti-inflammatory properties can also slow down liver inflammation caused by damaging factors. The sedative and tranquilizing effect of Eucommia can help further regulate the body's qi and relieve liver qi.

[0018] Buddha's hand: warm, pungent, bitter, sour, it enters the liver, spleen, stomach, and lung meridians, can soothe the liver and regulate qi, soothe the stomach and relieve pain, and dry dampness and resolve phlegm. The effect of Buddha's hand on soothing the liver and regulating qi can effectively relieve liver depression and qi stagnation, and promote the circulation of drug effects throughout the body. Modern research has found that the chemical composition of Buddha's hand is mainly composed of polysaccharides, volatile oils, flavonoids, coumarins and other components, which can play anti-inflammatory, antioxidant, lipid-lowering, and anti-depressant effects.

[0019] White lentil flower: neutral, sweet, enters the spleen and stomach meridians, can resist bacteria and reduce inflammation, nourish the spleen and stomach, and eliminate dampness and relieve heat. Liver qi is blocked, and water and dampness are not regulated smoothly, causing liver and gallbladder dampness and heat. White lentil flower can strengthen the spleen and remove dampness, and assist in the dissolution of dampness and heat. At the same time, the characteristics of white lentil flower in strengthening the spleen and stomach can also help other drug ingredients in the body, prevent the intake of tonic drugs from damaging the spleen, and protect gastrointestinal function.

[0020] Poria: It is mild, sweet, and light. It is good for the heart, lung, spleen, and kidney meridians. It can promote diuresis and eliminate dampness, strengthen the spleen, and calm the mind. Modern pharmacological research shows that Poria mainly contains triterpenes, polysaccharides, sterols, diterpenes, proteins, amino acids, organic acids and their esters, flavonoids, and other ingredients. It has a variety of pharmacological effects such as diuresis, immunity enhancement, gastrointestinal function regulation, anti-tumor, liver protection, and sedation. Poria polysaccharide can significantly alleviate the related symptoms of histological liver damage and impaired liver function caused by non-alcoholic fatty liver.

[0021] 2. The medicinal and edible plant composition provided by the present invention is based on the overall idea of ​​protecting and nourishing the liver, and has been invented and designed in multiple aspects such as etiology, injury mechanism, TCM syndrome differentiation, modern medical research, balance of medicinal properties, safety of the composition, availability of the composition, and taste of the composition. With regard to the etiology, not only the chemical injury factors and lipid metabolism factors in modern medicine are considered, but also the syndrome differentiation of the liver and gallbladder in the eight-category syndrome differentiation of TCM is fully referred to. While conditioning the liver, it also focuses on the regulation of multiple pathways such as anti-inflammatory and antioxidant, blocking the progress of injury, and inhibiting injury from the source of the injury mechanism. The composition used in the present invention has the liver-protecting effects of both TCM and modern medicine, and the drug efficacy is clearly divided and mutually promoted. At the same time, adjustments have been made to the compatibility of medicinal properties, so that the medicinal properties of the entire composition tend to be peaceful, avoiding physical discomfort caused by excessive cold or overheating. And the composition of the present invention also fully considers the overall condition of the user's body. Most users who need to protect the liver are accompanied by discomfort in the spleen and stomach. In addition, there are tonic ingredients in the composition, so the spleen and stomach nourishing ingredients with liver protection effects are specially added to help the absorption of the drug and will not cause physical discomfort. At the same time, the composition ingredients described in the present invention are all from the medicine and food homology catalog, have good safety, and long-term use within the limited dosage will not cause damage to the body. At the same time, the raw materials of the composition are easy to obtain, the price is relatively low, and it is more suitable for general use among the crowd. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 The extract of the present invention improves the elevated alanine aminotransferase (ALT) in liver injury mouse models

[0023] Figure 2 The extract of the present invention improves the elevated aspartate aminotransferase (AST) in a liver injury mouse model

[0024] Figure 3 The extract of the present invention improves the increase of low-density lipoprotein (LDL) in liver injury mouse model DETAILED DESCRIPTION

[0025] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms fall within the scope limited by the appended claims of the application equally.

[0026] Example 1

[0027] 1. This embodiment provides a medicinal and edible plant composition with liver-protecting function, comprising the following raw materials in parts by weight: 15 parts of wolfberry, 15 parts of cassia seed, 15 parts of gardenia, 15 parts of angelica, 10 parts of eucommia leaves, 10 parts of bergamot, 10 parts of white hyacinth bean flowers, and 10 parts of poria.

[0028] 2. Directions: Soak in 300 mL of water above 90°C for 5-10 minutes. Take one dose per day. Soaking can be repeated three times. Take warm 30 minutes after meals.

[0029] 3. Observation course: 4 weeks is one course of treatment, and two courses of treatment is one cycle. If symptoms are not relieved after one course of treatment, stop taking the medicine. Each cycle is 4 weeks apart.

[0030] Example 2

[0031] 1. This embodiment provides a medicinal and edible plant composition with liver-protecting function, comprising the following raw materials in parts by weight: 16 parts of wolfberry, 14 parts of cassia seed, 12 parts of gardenia, 12 parts of angelica, 15 parts of eucommia leaves, 8 parts of bergamot, 8 parts of white hyacinth bean flower, and 15 parts of poria.

[0032] 2. Dosage: decoction in water, concentrated decoction (1500ml of water to produce 500ml of medicinal juice), one dose per day, once in the morning, noon and evening, take warm 30 minutes after meals.

[0033] 3. Observation course: 2 weeks is one course of treatment, and four courses are continued. If symptoms are not relieved after one course of treatment, stop taking the medicine.

[0034] Based on the above embodiment 1, the following case is given:

[0035] Example case 1:

[0036] Patient Information:

[0037] Name: Mr. Liu, Gender: Male, Age: 30, Weight: 85 kg, Height: 182 cm.

[0038] Medical history: staying up late for a long time, irregular diet, high blood lipids, normal blood pressure and blood sugar, no diabetes.

[0039] Chief complaints: dizziness, red eyes, dry throat and bitter mouth in the morning, night sweats, sweaty and hot palms, occasional chest pain, loss of appetite, irritability and stuffiness.

[0040] Diagnosis: Moderate nonalcoholic fatty liver disease, confirmed by liver ultrasound and blood tests.

[0041] Recommended treatment plan: 1 dose per day, orally.

[0042] Therapeutic effect: After taking it for 2 months, the main symptoms disappeared, blood lipids returned to normal, and weight decreased to 80 kg.

[0043] Based on the above embodiment 2, the following case is given:

[0044] Example case 1:

[0045] Patient Information:

[0046] Name: Bao Nusheng, Gender: Female, Age: 59, Weight: 60 kg, Height: 163 cm.

[0047] Medical history: high blood lipids, normal blood pressure, diabetes, and good blood sugar control in the past.

[0048] Chief complaint: dry throat and bitter mouth in the morning, night sweats, occasional chest pain, irritability and shortness of breath, and occasional nausea and vomiting at night.

[0049] Diagnosis: moderate nonalcoholic fatty liver disease, sludge-like lesions in the intrahepatic bile duct, confirmed by liver ultrasound and blood tests.

[0050] Recommended treatment plan: 1 dose per day, three times a day, orally after meals.

[0051] Therapeutic effect: After taking the medicine for one month, the main symptoms disappeared, blood lipids returned to normal, and the sludge-like lesions in the liver did not progress.

[0052] Example 3

[0053] Effect of the extract of the composition mentioned in the present invention on liver function of liver injury mouse model

[0054] 1. Experimental Materials

[0055] Twenty SPF male C57BL / 6 mice (6 weeks old) weighing 19±0.5 g were fed with free access to water and food. The room temperature of the animal room was (25±2)°C, the relative humidity was 65%±3%, and the light / darkness was 12 h per day. The mice were adaptively raised for 2 weeks.

[0056] This embodiment provides a medicinal and edible plant composition with liver-protecting function, comprising the following raw materials in parts by weight: 16 parts of wolfberry, 14 parts of cassia seed, 12 parts of gardenia, 12 parts of angelica, 15 parts of eucommia leaves, 8 parts of citron, 8 parts of white labia flower, and 15 parts of poria.

[0057] 2. Experimental Grouping

[0058] There were 5 animals in each of the control group, model group, model + brewing group, and model + decoction group.

[0059] 3. Experimental Methods

[0060] Each group was given Lieber-DeCarli control liquid mouse diet for 5 days, and then the model group and the drug group were pre-adapted to the ethanol concentration, and fed from 1% concentration to 4% concentration for 1 day, and then fed with Lieber-DeCarli ethanol liquid mouse diet containing 5% ethanol for 40 days, and the blank control group was given an equal volume of control liquid mouse diet. The above components were soaked in 400mL of 95℃ water for 15 minutes to obtain the brewing liquid. The above components were boiled in 600mL of water for 30 minutes and then fixed to 400mL to obtain the boiled liquid. The drug was administered from the 20th day of 5% ethanol feeding, the model + brewing group was given brewing liquid, the model + decoction group was given boiled liquid, and the control group and the model group were given normal saline once a day, with an intragastric volume of 10mL / kg. After reaching the end of the experiment, the blood of the mice was taken for the determination of liver function related indicators.

[0061] 4. Experimental Results

[0062] The experimental results showed that compared with the model group, the levels of alanine aminotransferase (ALT) ( Figure 1 ) and aspartate aminotransferase (AST) ( Figure 2 ) decreased to varying degrees, and the decline in the decoction group was greater than that in the brewing group. At the same time, compared with the model group, the low-density lipoprotein (LDH) ( Figure 3 ) content also decreased, but there was no significant difference between the decoction group and the brewing group. The above results show that the extract of the composition of the present invention has a good effect of improving liver function.

[0063] Note: Compared with the blank control group, *P<0.05, **P<0.01.

[0064] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A medicinal and edible plant composition with liver protection function, characterized in that: The medicinal and edible plant composition is prepared from the following raw materials in parts by weight: 13-20 parts of wolfberry, 15-20 parts of cassia seed, 10-15 parts of gardenia, 10-15 parts of angelica, 6-15 parts of eucommia leaves, 7-13 parts of bergamot, 6-10 parts of white hyacinth bean flowers, and 10-15 parts of poria.

2. The medicinal and edible plant composition according to claim 1, characterized in that: The medicinal and edible plant composition is prepared from the following raw materials in parts by weight: 15 parts of wolfberry, 15 parts of cassia seed, 15 parts of gardenia, 15 parts of angelica, 10 parts of eucommia leaves, 10 parts of bergamot, 10 parts of white labia flower, and 10 parts of poria.

3. The medicinal and edible plant composition according to claim 1, characterized in that: The medicinal and edible plant composition is prepared from the following raw materials in parts by weight: 14 parts of wolfberry, 20 parts of cassia seed, 14 parts of gardenia, 14 parts of angelica, 6 parts of eucommia leaves, 14 parts of bergamot, 6 parts of white hyacinth bean flowers, and 12 parts of poria.

4. The medicinal and edible plant composition according to claim 1, characterized in that: The medicinal and edible plant composition is prepared from the following raw materials in parts by weight: 16 parts of wolfberry, 14 parts of cassia seed, 12 parts of gardenia, 12 parts of angelica, 15 parts of eucommia leaves, 8 parts of bergamot, 8 parts of white labia flower, and 15 parts of poria.

5. The medicinal and edible plant composition according to claims 1-4, characterized in that: It is a combination of cut corresponding dried parts of plants.

6. The medicinal and edible plant composition according to claims 1-4, characterized in that: The invention is any one of ointment, tablet, capsule, powder, gel candy, oral liquid or granule.

7. The medicinal and edible plant composition according to claims 1-4, characterized in that: The dried plant composition is soaked in water above 90°C for 5-15 minutes to obtain an extract.

8. The medicinal and edible plant composition according to claim 1, characterized in that: The dried plant composition of the medicinal and edible plant composition is crushed into powders with a particle size of more than 90% less than 45 microns using modern wall-breaking technology.

9. The medicinal and edible plant composition according to claim 1, characterized in that: The fresh plant composition of the medicinal and edible plant composition is broken with water in an amount 5 to 10 times the weight of the fresh plant composition to obtain a suspension.

10. Use of the medicinal and edible plant composition with liver protection function according to claim 1 in preventing liver damage and improving liver function.

11. The use of the medicinal and edible plant composition according to claim 10, characterized in that: The liver function damage includes abnormal liver function caused by excessive fatigue, obesity and alcohol.

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