Medicine for treating rheumatoid arthritis and preparation method thereof

Abstract

The invention provides a medicine for treating rheumatoid arthritis and a preparation method thereof, and belongs to the technical field of Chinese herbal medicines. The medicine for treating rheumatoid arthritis is prepared from the following raw material medicines in parts by weight: 80 to 100g of semen coicis, 25 to 45g of poria cocos, 10 to 25g of radix achyranthis bidentatae, 10 to 25g of radix gentianae macrophyllae, 5 to 15g of rhizoma atractylodis, 5 to 15g of cortex phellodendri, 5 to 15g of rhizoma alismatis, 15 to 25g of radix clematidis, 10 to 20g of radix codonopsis, 10 to 25g of earthworm, 10 to 20g of semen brassicae, 8 to 10g of cassia twig, 10 to 15g of rhizoma atractylodis macrocephalae, 10 to 15g of honey-fried licorice root, 25 to 35g of ramulus mori, 25 to 35g of honeysuckle flower, 10 to 20g of semen persicae, 1015g of radix aconiti preparata and 15 to 25g of radix paeoniae alba. The traditional Chinese medicine is suitable for cold patients in cooperation with 1-5 g of asarum and 10-20 g of corydalis tuber, is suitable for hot patients in cooperation with 10-20 g of oyster and 10-15 g of rhizoma anemarrhenae, is suitable for kidney deficiency patients in cooperation with 10-20 g of herba epimedii, 10-20 g of fructus lycii and 25-35 g of herba taxilli, and is suitable for blood stasis patients in cooperation with 25-35 g of salvia miltiorrhiza, 10-20 g of radix paeoniae rubra, 1-3 g of leonurus and 10-20 g of caulis spatholobi. The medicine has the effects of dispelling wind, eliminating dampness, promoting blood circulation to remove blood stasis, enhancing immunity and the like, is reasonable in compatibility, short in treatment course, remarkable in curative effect and free of toxic and side effects and can achieve the effect of treating both symptoms and root causes.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese herbal medicines, and in particular relates to a medicine for treating rheumatoid arthritis and a preparation method thereof. Background Art

[0002] Rheumatoid arthritis belongs to the category of "arthralgia" in traditional Chinese medicine. The clinical classification of arthralgia is mainly based on four types: wind, cold, dampness and heat. Among them, wind prevails and the patient is good at wandering, which is called "xingbi", cold prevails and the patient is in severe pain, which is called "tongbi", dampness prevails and the patient is in swelling, which is called "zhubi", and heat prevails and the patient is in local or whole body with fever, which is called "rebi". The main characteristics of rheumatoid arthritis are joint swelling and pain, wandering, and hot pain. It has the common characteristics of the four types of wind, cold, dampness and heat, and it is not easy to classify.

[0003] The root of rheumatoid arthritis is spleen deficiency, and its symptom is dampness and turbidity. The spleen and stomach are the foundation of the acquired constitution and the source of qi and blood biochemical transformation. The muscles, limbs and bones of the human body all rely on the nourishment of the fine substances of water and grain to maintain their normal functional activities. When the spleen is weak, water and grain cannot be normally circulated and excreted, which causes dampness to stagnate in the internal organs and meridians. Dampness is yin, soft, heavy, turbid and sticky. It is most likely to block the qi mechanism when it is retained in the internal organs and meridians, resulting in poor meridian blockage and water metabolism disorder. Therefore, this disease first originates from the dysfunction of the spleen, which in turn leads to the retention of dampness and turbidity and the accumulation of dampness and turbidity in the internal organs. The spleen is responsible for transporting and transforming the clear, and its nature likes dryness and hates dampness. The retention of dampness and evil often traps the spleen, affecting the spleen's operation and forming a vicious cycle. Therefore, clinically seen patients with rheumatoid arthritis often have dampness and turbidity stagnant in the blood and cannot be discharged. At first, they do not feel pain, but gradually accumulate over time, the more stagnant it is, the more severe it is, and it will eventually block the meridians and cause sudden swelling and pain in the bones and joints.

[0004] Rheumatoid disease is a chronic systemic immune disease with joint lesions as the main feature. All parts of the joints can be affected, especially small joints. In the early or acute stage of the disease, the affected joints show redness, swelling, heat, pain and movement disorders. In the late stage of the disease, joint stiffness or deformity often occur, and serious loss of ability to work is caused. Due to the long course of rheumatoid disease and the complicated process of the disease, it is difficult to cure it. At present, Western medicine treatment for this disease uses non-steroidal anti-inflammatory analgesics and hormones, which are mainly used to relieve symptoms. The therapeutic effect cannot be consolidated, and it can only treat the symptoms, not the root cause, and has large side effects.

[0005] Currently, there are many traditional Chinese medicines for the treatment of rheumatoid arthritis, but most of them have complex formulas, and some contain hormones and many toxic ingredients, which can easily cause complications. Not only are the side effects significant, but the effects are not obvious, or they cannot cure the disease, and the disease is prone to relapse after discontinuation of the medication. Summary of the invention

[0006] In view of this, the purpose of the present invention is to provide a drug for treating rheumatoid arthritis and a preparation method thereof, so as to overcome the problem that the drugs in the prior art have great toxic and side effects and poor effects.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] The invention provides a medicine for treating rheumatoid arthritis, comprising the following raw materials in parts by weight: 80-100g of coix seed, 25-45g of tuckahoe, 10-25g of cyathula, 10-25g of gentiana macrophylla, 5-15g of atractylodes, 5-15g of phellodendron, 5-15g of oriental rhizome, 15-25g of clematis, 10-20g of codonopsis pilosula, 10-25g of earthworm, 10-20g of white mustard seed, 8-10g of cassia twig, 10-15g of atractylodes, 10-15g of roasted liquorice, 25-35g of mulberry branch, 25-35g of honeysuckle, 10-20g of peach kernel, 10-15g of processed aconite and 15-25g of white peony root.

[0009] Preferably, the drug for treating rheumatoid arthritis comprises the following raw materials in parts by weight: coix seed 85-95g, Poria 28-40g, Achyranthes bidentata 12-23g, Gentiana macrophylla 14-21g, Atractylodes lancea 7-14g, Phellodendron chinense 6-12g, Alisma orientalis 8-12g, Clematidis 12-23g, Codonopsis pilosula 13-18g, Pheretima lumbar disc 12-22g, Sinapis alba 13-17g, Cassia twig 8-10g, Atractylodes macrocephala 11-14g, Radix Glycyrrhizae uralensis 11-14g, Morus twig 22-33g, Flos lonicerae 22-33g, Semen persicae 13-18g, Processed Aconite 10-15g, and White Peony 16-24g.

[0010] Preferably, the drug for treating rheumatoid arthritis comprises the following raw materials in parts by weight: 90g of coix seed, 30g of Poria, 15g of Achyranthes bidentata, 20g of Gentiana macrophylla, 10g of Atractylodes macrocephala, 10g of Phellodendron chinense, 10g of Alisma orientalis, 20g of Clematidis, 15g of Codonopsis pilosula, 15g of Pheretima, 15g of White Sinapis, 9g of cinnamon twig, 12g of Atractylodes macrocephala, 12g of Radix Glycyrrhizae Preparata, 30g of Morus alba, 30g of Honeysuckle, 15g of Peach Kernel, 12g of Processed Aconite, and 20g of White Peony Root.

[0011] Preferably, the drug for treating rheumatoid arthritis further comprises the following raw materials in parts by weight: 1-5g of asarum and 10-20g of Corydalis yanhusuo.

[0012] Preferably, the drug for treating rheumatoid arthritis further comprises the following raw materials in parts by weight: 10-20g of oyster, 10-15g of Anemarrhena asphodeloides

[0013] Preferably, the drug for treating rheumatoid arthritis further comprises the following raw materials in parts by weight: 10-20 g of epimedium, 10-20 g of wolfberry, and 25-35 g of mistletoe.

[0014] Preferably, the drug for treating rheumatoid arthritis further comprises the following raw materials in parts by weight: 25-35g of Salvia miltiorrhiza, 10-20g of Red Peony Root, 1-3g of Leonurus japonicus, and 10-20g of Millettia reticulata.

[0015] The present invention also provides a method for preparing a drug for treating rheumatoid arthritis, comprising the following steps:

[0016] 1) Weigh each API by weight: wash and chop each API for later use.

[0017] 2) Add each raw material into water with a mass 3-5 times the total mass of the dry raw materials, soak in cold water for 80-120 minutes, then boil over low heat, keep boiling for 40-80 minutes, filter the residue and obtain the first decoction.

[0018] 3) Take the residue and decoct it again for 1-2 times. Each time you decoct it again, add 2-3 times the total amount of water of the dry raw materials. Soak it in cold water for 180-210 minutes, then boil it over low heat. Keep boiling for 30-60 minutes, filter the residue to obtain the decoction; combine the first decoction and the decoction, mix well and filter to obtain the medicinal solution.

[0019] The pharmacological effects of the raw material medicine used in the present invention are as follows:

[0020] Coix seeds: sweet, light, slightly cold, enter the spleen, stomach, and lung meridians. The main effects are diuresis, invigorating the spleen and stopping diarrhea, clearing away heat and pus, and removing numbness.

[0021] Poria: Poria tastes sweet, light, mild and non-toxic. It enters the heart, spleen, lung and kidney meridians. It has the effects of dissipating dampness and promoting diuresis, benefiting the spleen and stomach and protecting the kidneys, calming the nerves and promoting body fluid.

[0022] Achyranthes bidentata: The root of Achyranthes bidentata is used as medicine. Raw use can promote blood circulation and menstruation. It is mainly used to treat abdominal pain after childbirth, irregular menstruation, amenorrhea, epistaxis, toothache due to deficiency of fire, beriberi and edema. Cooked use can nourish the liver and kidney, strengthen the waist and knees. It is mainly used to treat sore waist and knees, liver and kidney deficiency, and pain caused by trauma. Veterinarians use it to treat cattle with soft feet, broken bones, etc.

[0023] Gentiana macrophylla: slightly warm in nature, bitter and pungent in taste, slightly yang in the yin, can ascend or descend, enters the Yangming meridian of the hand. Cold and heat evil qi, cold and damp wind arthralgia, pain in the limbs, relieve water and promote urination. Treat wind regardless of age, and whole body cramps. Transmit corpse bone steaming, treat malnutrition and timely qi. Take with milk, promote urination and defecation, treat wine yellow, jaundice, detoxify alcohol, and remove headaches. Remove Yangming rheumatism, and paralysis of hands and feet, lockjaw, toothache, mouth sores, intestinal wind and blood, nourish blood and nourish tendons. Dissipate heat, and benefit gallbladder qi. Treat fever due to stomach heat and fatigue.

[0024] Atractylodes: The rhizome of Atractylodes is used as medicine, which is a spleen-regulating medicine. It is bitter, warm and pungent in nature, and has the effects of drying dampness, clearing turbidity and relieving pain.

[0025] Huangbai: bitter in nature and cold in flavor. Meridians: kidney, bladder, large intestine. Indications: damp-heat dysentery, diarrhea, jaundice; nocturnal emission, stranguria, leucorrhea; bone steaming, fatigue fever, night sweats; oral ulcers; red and swollen eyes; carbuncle and ulcer; skin eczema.

[0026] Alisma: Mainly used to treat nephritis edema, pyelitis, enteritis diarrhea, and difficulty urinating.

[0027] Clematis: bitter, warm, non-toxic. It can relieve all kinds of wind, clear the five internal organs, remove cold stagnation in the abdomen, phlegm and water in the heart and diaphragm, pus and water in the bladder due to long-term accumulation, cold pain in the waist and knees, and treat fractures. Long-term use will not cause fever, epidemics and malaria. It can dispel new and old stagnation, eliminate phlegm and saliva in the chest, and disperse wind evil in the skin and large intestine.

[0028] Codonopsis: It has the effects of enhancing immunity, dilating blood vessels, lowering blood pressure, improving microcirculation, and enhancing hematopoietic function.

[0029] Earthworm: salty, cold, non-toxic. Turns into water, treats colds, latent heat, madness, big belly and jaundice. Warm disease, severe fever. Treats colds, malaria, headache, toothache, wind-heat red eyes, tongue numbness, nasal breathing, ears, baldness, sores, ovum, prolapse of the anus, detoxifies spider venom, boils, scorpions and ears.

[0030] White mustard seeds: warm the lungs, dissipate phlegm and promote qi, disperse breast stagnation, dredge meridians and relieve pain. Used for cough due to cold phlegm, chest and flank pain, phlegm stagnation in the meridians, numbness and pain in the joints, phlegm and dampness, and swelling and poison in the genitals.

[0031] Cinnamon twig: pungent, sweet, warm, enters the lung, heart and bladder meridians. It induces sweating and relieves muscle pain, warms and dredges the meridians, and helps yang and transforms qi.

[0032] Atractylodes macrocephala: bitter, sweet, warm in nature. Enters the spleen and stomach meridians. Strengthens the spleen and replenishes qi, warms and promotes diuresis, stops sweating, and calms the fetus. Used for spleen deficiency, poor appetite, diarrhea, phlegm and fluid, dizziness, palpitations, edema, spontaneous incontinence, and restless fetus. Atractylodes macrocephala strengthens the spleen, harmonizes the stomach, and calms the fetus. Used for spleen deficiency, poor appetite, diarrhea, loose stools, and restless fetus.

[0033] Roasted Licorice: It has the therapeutic effects of invigorating Qi and nourishing Yin, promoting Yang and restoring meridians.

[0034] Mulberry branch: dispels rheumatism, benefits joints, and promotes the flow of water. It can treat wind-cold-damp arthralgia, cramps in the limbs, beriberi and edema, and itching of the body.

[0035] Honeysuckle: It has been praised as a good medicine for clearing away heat and detoxifying since ancient times. It is sweet, cold and aromatic. It can clear away heat without hurting the stomach. Its fragrance is penetrating and can dispel evil. Honeysuckle can not only dissipate wind-heat, but also clear away blood toxins. It is used for various febrile diseases, such as fever, rash, spots, heat-toxic sores, sore throat, etc., and the effect is remarkable.

[0036] Peach kernel: It has the effects of promoting blood circulation and removing blood stasis, moistening the intestines and relieving constipation, relieving cough and relieving asthma. It is used for amenorrhea, dysmenorrhea, lumps and masses, lung and intestinal abscesses, injuries from falls, constipation caused by dry intestines, cough and asthma.

[0037] Processed Chuanwu: bitter, hot; toxic. Enters the heart, liver, kidney, and spleen meridians. Expels wind and dampness, warms the meridians and relieves pain. Used for wind-cold-dampness arthralgia, breast pain, chest distension and pain, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, and anesthesia and pain relief.

[0038] White Peony Root: nourishes blood and restrains Yin, softens the liver and relieves pain, and calms the liver yang. Calms the liver and relieves pain, nourishes blood and regulates menstruation, restrains Yin and stops sweating. Used for headache, dizziness, flank pain, abdominal pain, cramps in the limbs, blood deficiency and sallow complexion, irregular menstruation, spontaneous sweating, and night sweats.

[0039] Asarum: pungent, warm, non-toxic. Cough, shortness of breath, headache, cramps in all joints, rheumatic arthralgia and muscle stiffness.

[0040] Corydalis yanhusuo: Corydalis yanhusuo is used as medicine with its tubers, which have the functions of promoting blood circulation, dispersing blood stasis, regulating qi and relieving pain. It is mainly used to treat pain in the heart, abdomen, waist and knees, bruises, pain caused by blood stasis, irregular menstruation, etc. It is a traditional painkiller.

[0041] Oyster: salty, slightly cold. Enters the liver, gallbladder, and kidney meridians. It is a liver-calming and wind-extinguishing medicine, and a yin-nourishing medicine.

[0042] Rhizoma Anemarrhenae: bitter, cold, non-toxic. Eliminates thirst, heat, removes evil spirits, limb edema, relieves water retention, replenishes deficiency, and invigorates Qi. Treats colds, chronic malaria, fever, evil spirits under the hypochondrium, nausea in the diaphragm, and jaundice caused by wind and cold.

[0043] Epimedium: The whole herb of Epimedium is used for medicinal purposes. It is mainly used to treat premature ejaculation, backache, leg pain, numbness of limbs, hemiplegia, neurasthenia, forgetfulness, tinnitus, dizziness and other symptoms.

[0044] Lycium barbarum: nourishes the kidney, moistens the lungs, replenishes the liver, and improves eyesight. Treats liver and kidney yin deficiency, soreness of the waist and knees, dizziness, blurred vision, excessive tears, consumptive cough, thirst, and spermatorrhea.

[0045] Mistletoe: It has the effects of eliminating rheumatism, benefiting the liver and kidneys, strengthening the bones and muscles, and calming the fetus.

[0046] Danshen: The root of this plant is used as medicine. It contains tanshinone, which is a strong and emmenagogue. It has the effects of removing blood stasis, promoting new blood, activating blood circulation, and regulating menstruation. It is an important gynecological medicine. It is mainly used to treat uterine bleeding, irregular menstruation, blood stasis, abdominal pain, dysmenorrhea, amenorrhea, and temple pain. It has a good effect on the treatment of coronary heart disease. In addition, it can also treat neurasthenia and insomnia, joint pain, anemia, mastitis, lymphadenitis, arthritis, sores, carbuncle, erysipelas, acute and chronic hepatitis, pyelonephritis, traumatic injury, hepatosplenomegaly in late schistosomiasis, and epilepsy. It can also be used to wash lacquer sores for external use.

[0047] Red Peony Root: Bitter, slightly cold. Enters the Liver Channel. Has the effects of clearing away heat, cooling blood, promoting blood circulation and removing blood stasis.

[0048] Motherwort: Motherwort is used as medicine, and its active ingredient is motherwortin. Oral administration can dilate blood vessels and lower blood pressure, and it has an adrenaline antagonist effect, which can treat arteriosclerotic and neurotic hypertension. It can also increase the frequency of uterine movement. It is a drug that promotes uterine contraction after childbirth, and is effective for those who are weak due to long-term uterine bleeding. Therefore, it is widely used to treat women with amenorrhea, dysmenorrhea, irregular menstruation, excessive postpartum bleeding and lochia, incomplete postpartum uterine contraction, fetal movement disorder, uterine prolapse, and red and white vaginal discharge.

[0049] Millettia reticulata: It has the functions of nourishing the liver and kidneys, improving essence and strengthening yang, and stopping diarrhea.

[0050] Compared with the prior art, the present invention has the following beneficial effects:

[0051] The present invention combines asarum and yanhusuo on the basis of the basic prescription to treat patients with cold tendencies, combines oyster and anemarrhena to treat patients with heat tendencies, combines epimedium, wolfberry fruit and mistletoe to treat patients with kidney deficiency, and combines salvia miltiorrhiza, red peony root, motherwort and millettia to treat patients with blood stasis.

[0052] The medicine of the present invention has the effects of regulating meridians, strengthening tendons and bones, strengthening the body, nourishing qi and blood, replenishing qi and benefiting essence, dispelling wind and dampness, promoting blood circulation, regulating endocrine, enhancing immunity, etc. The medicine has reasonable compatibility, short treatment course, significant curative effect, no toxic side effects, and can achieve the effect of treating both the symptoms and the root causes. DETAILED DESCRIPTION

[0053] The invention provides a medicine for treating rheumatoid arthritis, comprising the following raw materials in parts by weight: 80-100g of coix seed, 25-45g of tuckahoe, 10-25g of cyathula, 10-25g of gentiana macrophylla, 5-15g of atractylodes, 5-15g of phellodendron, 5-15g of oriental rhizome, 15-25g of clematis, 10-20g of codonopsis pilosula, 10-25g of earthworm, 10-20g of white mustard seed, 8-10g of cassia twig, 10-15g of atractylodes, 10-15g of roasted liquorice, 25-35g of mulberry branch, 25-35g of honeysuckle, 10-20g of peach kernel, 10-15g of processed aconite and 15-25g of white peony root.

[0054] In the present invention, the drug for treating rheumatoid arthritis includes the following raw materials in parts by weight: 85-95g of coix seed, 28-40g of Poria, 12-23g of Achyranthes bidentata, 14-21g of Gentiana macrophylla, 7-14g of Atractylodes macrocephala, 6-12g of Phellodendron chinense, 8-12g of Alisma orientalis, 12-23g of Clematidis, 13-18g of Codonopsis pilosula, 12-22g of Pheretima viride, 13-17g of Sinapis alba, 8-10g of cinnamon twig, 11-14g of Atractylodes macrocephala, 11-14g of roasted liquorice, 22-33g of mulberry twig, 22-33g of honeysuckle, 13-18g of peach kernel, 10-15g of processed Chuanwu and 16-24g of white peony root.

[0055] In the present invention, the drug for treating rheumatoid arthritis includes the following raw materials in parts by weight: 90g of coix seed, 30g of Poria, 15g of Achyranthes bidentata, 20g of Gentiana macrophylla, 10g of Atractylodes macrocephala, 10g of Phellodendron chinense, 10g of Alisma orientalis, 20g of Clematidis, 15g of Codonopsis pilosula, 15g of Pheretima, 15g of White Sinapis, 9g of cinnamon twig, 12g of Atractylodes macrocephala, 12g of Radix Glycyrrhizae Preparata, 30g of Morus alba, 30g of Honeysuckle, 15g of Peach Kernel, 12g of Processed Aconite, and 20g of White Peony Root.

[0056] In the present invention, the drug for treating rheumatoid arthritis also includes the following raw materials in parts by weight: 1-5g of asarum and 10-20g of Corydalis yanhusuo; more preferably 15g; the asarum is preferably 2-4g, more preferably 3g; the Corydalis yanhusuo is preferably 13-17g, more preferably 15g.

[0057] In the present invention, the drug for treating rheumatoid arthritis also includes the following raw materials in parts by weight: 10-20g of oyster and 10-15g of Anemarrhena asphodeloides; the oyster is preferably 12-18g, and more preferably 15g; the Anemarrhena asphodeloides is preferably 11-14g, and more preferably 12g.

[0058] In the present invention, the drug for treating rheumatoid arthritis also includes the following raw materials in parts by weight: 10-20g of epimedium, 10-20g of wolfberry, and 25-35g of mistletoe; the epimedium is preferably 12-16g, and more preferably 15g; the wolfberry is preferably 13-16g, and more preferably 15g; the mistletoe is preferably 17-32g, and more preferably 30g.

[0059] In the present invention, the drug for treating rheumatoid arthritis also includes the following raw materials in parts by weight: 25-35g of Salvia miltiorrhiza, 10-20g of red peony root, 1-3g of Leonurus japonicus, and 10-20g of Millettia spatholobi; the Salvia miltiorrhiza is preferably 18-32g, and more preferably 30g; the red peony root is preferably 12-18g, and more preferably 15g; the Millettia spatholobi is preferably 13-17g, and more preferably 15g.

[0060] The present invention also provides a method for preparing a drug for treating rheumatoid arthritis, comprising the following steps:

[0061] 1) Weigh each API by weight: wash and chop each API for later use.

[0062] 2) Add each raw material into water with a mass 3-5 times the total mass of the dry raw materials, soak in cold water for 80-120 minutes, then boil over low heat, keep boiling for 40-80 minutes, filter the residue and obtain the first decoction.

[0063] 3) Take the residue and decoct it again for 1-2 times. Each time you decoct it again, add 2-3 times the total amount of water of the dry raw materials. Soak it in cold water for 180-210 minutes, then boil it over low heat. Keep boiling for 30-60 minutes, filter the residue to obtain the decoction; combine the first decoction and the decoction, mix well and filter to obtain the medicinal solution.

[0064] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0065] Example 1

[0066] Take 90g of coix seed, 30g of Poria, 20g of Achyranthes bidentata, 10-25 of Gentiana macrophylla, 10g of Atractylodes lancea, 10g of Phellodendron chinense, 10g of Orientalis rhizome, 20g of Clematidis radix, 15g of Codonopsis pilosula, 15g of Pheretima lum, 15g of White mustard seed, 9g of cinnamon twig, 12g of Atractylodes macrocephala, 12g of Radix Glycyrrhizae Preparata, 30g of Morus alba, 30g of Flos Lonicerae, 15g of Semen Persicae, 12g of Radix Aconiti Radix and 20g of White Peony Root, wash and chop, add water of 4 times the mass of dry raw materials, soak in cold water for 100 minutes, boil over low heat, keep boiling for 60 minutes, filter the residue, and obtain the first decoction. Take the residue and decoct it again once. When decocting again, add water of 2 times the mass of dry raw materials, soak in cold water for 190 minutes, boil over low heat, keep boiling for 50 minutes, filter the residue, and obtain the decoction; combine the first decoction and the decoction, mix and filter, and obtain the liquid medicine.

[0067] Example 2

[0068] Take 90g of Coix seed, 30g of Poria, 20g of Achyranthes bidentata, 10-25g of Gentiana macrophylla, 10g of Atractylodes lancea, 10g of Phellodendron chinense, 10g of Alisma orientalis, 20g of Clematidis, 15g of Codonopsis pilosula, 15g of Pheretima divaricata, 15g of White Sinapis seed, 9g of Cassia twig, 12g of Atractylodes macrocephala, 12g of Radix Glycyrrhizae uralensis, 30g of Morus twig, 30g of Honeysuckle, 15g of Peach kernel, 12g of Processed Chuanwu, 20g of White Peony Root, 3g of Asarum, and 15g of Corydalis yanhusuo, wash and chop, add water with a mass 3 times the total amount of dry raw materials, soak in cold water for 90 minutes, then boil over low heat, keep boiling for 50 minutes, filter the residue to obtain the first decoction. Take the residue and decoct it again. When decoction is repeated, add water 3 times the total amount of the dry raw materials. Soak in cold water for 180 minutes and then boil over low heat. Keep boiling for 40 minutes, filter the residue to obtain the decoction; combine the first decoction and the decoction, mix well and filter to obtain the medicinal solution.

[0069] Example 3

[0070] Take 90g of Coix seed, 30g of Poria, 20g of Achyranthes bidentata, 10-25g of Gentiana macrophylla, 10g of Atractylodes lancea, 10g of Phellodendron chinense, 10g of Alisma orientalis, 20g of Clematidis, 15g of Codonopsis pilosula, 15g of Pheretima divaricata, 15g of White Sinapis seed, 9g of Cassia twig, 12g of Atractylodes macrocephala, 12g of Roasted Licorice root, 30g of Morus twig, 30g of Honeysuckle, 15g of Peach kernel, 12g of Processed Chuanwu, 20g of White Peony Root, 15g of Oyster, and 12g of Anemarrhena asphodeloides. Wash and chop, add water with a mass 5 times the total amount of dry raw materials, soak in cold water for 90 minutes, then boil over low heat. Keep boiling for 40 minutes, filter the residue to obtain the first decoction. Take the medicinal residue and decoct it again. When decoction is repeated, add water 3 times the total amount of the dry medicinal materials. Soak in cold water for 180 minutes and then boil over low heat. Keep boiling for 60 minutes, filter the medicinal residue to obtain the decoction; combine the first decoction and the decoction, mix well and filter to obtain the medicinal solution.

[0071] Example 4

[0072] Take 90g of coix seed, 30g of Poria, 20g of Achyranthes bidentata, 10-25g of Gentiana macrophylla, 10g of Atractylodes lancea, 10g of Phellodendron chinense, 10g of Alisma orientalis, 20g of Clematidis, 15g of Codonopsis pilosula, 15g of Pheretima viridis, 15g of White Sinapis seed, 9g of cinnamon twig, 12g of Atractylodes macrocephala, 12g of roasted Licorice root, 30g of Morus alba, 30g of Honeysuckle, 15g of Peach kernel, 12g of processed Chuanwu, 20g of White Peony Root, 15g of Epimedium, 15g of Lycium barbarum, and 30g of Taxillus parasiticus. Wash and chop, add water with a mass 4 times the total amount of dry raw materials, soak in cold water for 100 minutes, then boil over low heat. Keep boiling for 60 minutes, filter the residue to obtain the first decoction. Take the medicinal residue and decoct it again. When decoction is repeated, add water that is twice the total amount of the dry medicinal materials. Soak in cold water for 190 minutes, then boil over low heat. Keep boiling for 50 minutes, filter the medicinal residue to obtain the decoction; combine the first decoction and the decoction, mix well and filter to obtain the medicinal solution.

[0073] Example 5

[0074] Take 90g of Coix seed, 30g of Poria, 20g of Achyranthes bidentata, 10-25g of Gentiana macrophylla, 10g of Atractylodes macrocephala, 10g of Phellodendron chinense, 10g of Alisma orientalis, 20g of Clematidis, 15g of Codonopsis pilosula, 15g of Pheretima vicifolia, 15g of White Sinapis, 9g of Cinnamomum cassia, 12g of Atractylodes macrocephala, 12g of Radix Glycyrrhizae uralensis, 30g of Morus alba, 30g of Honeysuckle, 15g of Peach Kernel, 12g of Processed Chuanwu, 20g of White Peony Root, 30g of Salvia miltiorrhiza, 15g of Red Peony Root, 3g of Leonurus japonicus, and 15g of Millettia reticulata. Wash and chop, add water with a mass 5 times the total amount of dry raw materials, soak in cold water for 90 minutes, then boil over low heat. Keep boiling for 40 minutes, filter the residue to obtain the first decoction. Take the medicinal residue and decoct it again. When decoction is repeated, add water 3 times the total amount of the dry medicinal materials. Soak in cold water for 180 minutes and then boil over low heat. Keep boiling for 60 minutes, filter the medicinal residue to obtain the decoction; combine the first decoction and the decoction, mix well and filter to obtain the medicinal solution.

[0075] Experimental Example 1

[0076] The drug of the present invention is taken as one dose per day according to the preparation method of the present invention, decocted twice, mixed and taken three times. The efficacy is statistically analyzed after continuous treatment for 6 months.

[0077] After 100 cases of clinical treatment, 75 cases were clinically relieved, accounting for 75%; 15 cases were markedly effective, accounting for 15%; 10 cases were effective, accounting for 10%. The total effective rate was 100%.

[0078] Clinically cured cases:

[0079] Chen, female, 45 years old, first diagnosed on January 12, 2018. The patient began to experience symmetrical pain in bilateral finger joints one year ago, and the condition recurred, sometimes mild and sometimes severe. The condition worsened in the past half month and came to our hospital for treatment. When she was diagnosed, she complained of symmetrical swelling and cold pain in the small joints of the limbs for more than one year, which worsened for half a month. The swelling and pain were mainly in the bilateral finger joints and knee joints, and the flexion and extension were not good and the movement was difficult. The joints are relieved when warm, and the pain cannot be touched. The joints are stiff for about 2 hours in the morning and improve after activity. The tongue coating is white and slippery, with teeth marks on the edges, the pulse is slow and slippery, and the physical examination shows: T36.4℃Bp120 / 70mmhg is normal in development, the nutrition is moderate, the consciousness is clear, the language is fluent, and walking is difficult. The bilateral temporomandibular joints are tender to touch, the mouth is limited, the lips are not cyanotic, the corners of the mouth are not deviated, the tongue is centered, the pharynx is not congested, and the tonsils are not enlarged. The neck is soft and can move freely. The thorax is symmetrical and has no deformity, and there is no enhancement or weakening. The percussion sound of both lungs is clear, and the breath sounds of both lungs are clear. No dry or wet rales are heard. There is no localized bulge in the precordial area, and the apical impulse is not diffused. There is no tremor when touched. The heart border is not large when percussed. The heart rate is 70 beats / min, the rhythm is regular, the heart sounds are strong, the abdomen is soft, there is no tenderness, rebound pain, muscle tension, and the liver and spleen are not reached under the ribs. There is no deformity of the spine, no percussion pain on the vertebrae, and the range of motion is normal. The proximal interphalangeal joints and metacarpophalangeal joints of the left hand and the proximal interphalangeal joints and metacarpophalangeal joints of the 2-5 right hand are swollen, tender to touch, and limited fisting. The right elbow joint is swollen, the skin temperature is slightly low, and the extension is limited. The left elbow joint is not swollen and the movement is limited. Both elbow joints are tender to touch. Both knee joints are not swollen, but there is tenderness to touch. The movement is not limited. The anterior and medial sides of the calcaneus of both feet are tender to touch. The lateral side of the left calcaneus is tender to touch. The 1st and 5th metatarsal joints are tender to touch. The 1st to 5th interphalangeal joints are tender to touch. There is no edema in both lower limbs. The bilateral body muscle strength is V level, and the muscle tension is normal. The knee tendon reflex is normal.

[0080] Auxiliary examinations: Rheumatoid factor: positive, erythrocyte sedimentation rate 88mm / h, ASO (-), CRP: positive, X-rays showed osteoporosis in the interphalangeal joints of both hands, accompanied by cystic destruction of the joint surfaces and narrowing of the joint space, consistent with rheumatoid changes.

[0081] Syndrome differentiation: The patient has deficiency of Ying and Wei Qi, loose pores, invasion of wind, cold and dampness, obstruction of meridians and joints, stagnation of Qi and blood, resulting in swelling, cold pain in joints, difficulty in flexion and extension, which is relieved by heat; the tongue coating is white and slippery, the pulse is deep and slow, the syndrome is of cold and dampness with Qi deficiency.

[0082] Traditional Chinese medicine diagnosis: Arthritis (cold-dampness, deficiency and blood stasis type) Western medicine diagnosis: rheumatoid arthritis.

[0083] The patient was treated with the medicine of the present invention, 1 dose per day, decocted in water 2 times, mixed and taken in 3 doses. After a follow-up visit four weeks later, the swelling and pain in the joints disappeared, the patient was able to move freely, and the patient was completely cured without recurrence.

[0084] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A drug for treating rheumatoid arthritis, characterized in that: The invention comprises the following raw materials in proportion by weight: 80-100g of coix seed, 25-45g of poria, 10-25g of achyranthes bidentata, 10-25g of chinensis, 5-15g of atractylodes, 5-15g of phellodendron, 5-15g of oriental rhizome, 15-25g of clematis, 10-20g of codonopsis pilosula, 10-25g of earthworm, 10-25g of white mustard seed, 7-12g of cassia twig, 10-15g of atractylodes, 10-15g of roasted licorice root, 25-35g of mulberry branch, 25-35g of honeysuckle, 10-20g of peach kernel, 10-15g of processed aconite and 15-25g of white peony root.

2. A drug for treating rheumatoid arthritis, characterized in that: The invention comprises the following raw materials in proportion by weight: coix seed 85-95g, poria 28-40g, achyranthes bidentata 12-23g, gentiana macrophylla 14-21g, atractylodes 7-14g, phellodendron 6-12g, oriental rhizome 8-12g, clematis 12-23g, codonopsis pilosula 13-18g, earthworm 12-22g, white mustard seed 13-17g, cassia twig 8-10g, atractylodes macrocephala 11-14g, roasted licorice root 11-14g, mulberry twig 22-33g, honeysuckle 22-33g, peach kernel 13-18g, processed aconite 10-15g, and white peony root 16-24g.

3. A drug for treating rheumatoid arthritis, characterized in that: The invention comprises the following raw materials in parts by weight: 90g of coix seed, 30g of poria, 15g of achyranthes bidentata, 20g of gentiana macrophylla, 10g of atractylodes, 10g of phellodendron, 10g of oriental water plantain, 20g of clematis, 15g of codonopsis pilosula, 15g of earthworm, 15g of white mustard seed, 9g of cinnamon twig, 12g of atractylodes macrocephala, 12g of roasted licorice root, 30g of mulberry branch, 30g of honeysuckle, 15g of peach kernel, 12g of processed aconite and 20g of white peony root.

4. The drug for treating rheumatoid arthritis according to claim 1, characterized in that: It also includes the following raw materials in parts by weight: 1-5g of asarum and 10-20g of Corydalis yanhusuo.

5. The drug for treating rheumatoid arthritis according to claim 1, characterized in that: It also includes the following raw materials in parts by weight: 10-20g of oyster and 10-15g of Anemarrhena.

6. The drug for treating rheumatoid arthritis according to claim 1, characterized in that: It also includes the following raw materials in parts by weight: 10-20g of epimedium, 10-20g of wolfberry, and 25-35g of mistletoe.

7. The drug for treating rheumatoid arthritis according to claim 1, characterized in that: It also includes the following raw materials in parts by weight: 25-35g of Salvia miltiorrhiza, 10-20g of red peony root, 1-3g of Leonurus japonicus, and 10-20g of Millettia reticulata.

8. The method for preparing the drug for treating rheumatoid arthritis according to any one of claims 1 to 7, characterized in that: The following steps are involved: 1) Weigh each API by weight: wash and chop each API for later use. 2) Add each raw material into water with a mass 3-5 times the total mass of the dry raw materials, soak in cold water for 80-120 minutes, then boil over low heat, keep boiling for 40-80 minutes, filter the residue and obtain the first decoction. 3) Take the medicinal residue and decoct it again for 1-2 times. Each time you decoct it again, add 2-3 times the total amount of water of the dry medicinal material. Soak it in cold water for 180-210 minutes, then boil it over low heat. Keep boiling for 30-60 minutes, filter the medicinal residue to obtain a decoction; combine the first decoction and the decoction, mix well and filter to obtain a medicinal solution.