Female private part care solution and preparation method thereof

Abstract

The invention relates to the technical field of gynecological recuperating, and particularly provides a female private part care solution and a preparation method thereof.The female private part care solution is prepared from rheum officinale, radix angelicae, radix curcumae, polygonum cuspidatum, catechu, dragon's blood and other components through the processes of alcohol leaching, flash extraction, reduced pressure distillation and the like. The female private part care solution disclosed by the invention is friendly to lactobacillus and forms a unique hemostasis-anti-inflammation-pain relieving-granulation promoting system to promote skin healing.

Description

Technical Field

[0001] The invention relates to the technical field of gynecological recuperation, and in particular to a female private parts care solution and a preparation method thereof. Background Art

[0002] The skin of women's private parts, especially the vulva, is sensitive and the balance of vaginal flora is fragile. When using hard or overly irritating sanitary products, irritating shower gels or soaps, wearing tight underwear, or failing to change sanitary napkins or panty liners in time, the friction and stimulation of the vulva can easily damage the skin. In addition, the current common practice of sitting for long periods of time can lead to poor local blood circulation in the private parts, making it difficult for the skin to heal itself, increasing the risk of skin damage and causing secondary infection. Further scratching can lead to larger areas of skin redness, ulcers, cracks and other skin problems.

[0003] Although the currently used erythromycin ointment has an anti-infection effect, on the one hand, as a broad-spectrum antibiotic, it is easy to kill beneficial lactobacilli and destroy the balance of private flora; on the other hand, it lacks the nourishing and healing effect and has a poor recovery effect on skin damage.

[0004] Therefore, a female private parts care solution that is friendly to lactobacillus and promotes skin healing and a preparation method thereof are needed. Summary of the invention

[0005] In order to solve the above problems, the present invention aims to provide a female private parts care liquid and a preparation method thereof.

[0006] In one aspect, the present invention provides a method for preparing a female private parts care solution, the method comprising the following steps: Take 15-20% of rhubarb, 14-18% of angelica dahurica, 11-15% of curcuma, 7-12% of knotweed, 6-10% of catechu, 4-8% of dragon's blood, 3-5% of calamine powder and make up the rest of the mass fraction of pure water, the total mass of the above substances is 0.5kg, chop and pass through a 20-mesh sieve, add 80% ethanol with a mass of 9 times the mass of the above medicinal materials, immerse at 46°C for 12h, add a flash extractor with a speed of 4000r / min, extract for 40s and then filter through 200 mesh to obtain an extract; add 0.2 times the mass of pure water to the coarsely filtered extract, and then distill under reduced pressure at 72°C and a vacuum degree of 800mbar until no liquid flows out continuously, collect the remaining liquid, add 88% lactic acid to adjust the pH to 3.5 to obtain the female private parts care solution.

[0007] Furthermore, the mass fraction of the rhubarb is 18%.

[0008] Furthermore, the mass fraction of the Angelica dahurica is 16%.

[0009] Furthermore, the mass fraction of Curcuma aromatica is 13%.

[0010] Furthermore, the mass fraction of the knotweed is 10%.

[0011] Furthermore, the mass fraction of catechu is 8%.

[0012] Furthermore, the mass fraction of the dragon's blood is 6%.

[0013] Furthermore, the mass fraction of the calamine powder is 4%.

[0014] On the other hand, the present invention provides a female private parts care liquid prepared by the preparation method of the female private parts care liquid as described above.

[0015] The present invention can bring the following beneficial effects: The female private parts care solution of the present invention is friendly to lactobacilli and forms a unique hemostasis-anti-inflammatory-pain relief-tissue regeneration system to promote skin healing; rhubarb cools blood and detoxifies, and its efficacy in treating epidermal ulcers is recorded in "Shenghui Fang" and "Weisheng Baojian", and is used in combination with catechu to stop bleeding and reduce swelling; angelica dahurica dispels cold and relieves pain, and has the efficacy of anti-inflammatory and swelling, and is used in combination with rhubarb to reduce swelling, and is used in combination with calamine to relieve pain and relieve itching; turmeric has an inhibitory effect on various skin fungi, and is used in combination with dragon's blood to prevent fungal infection of wounds; polygonum cuspidatum dispels blood stasis and promotes menstruation, and is rich in resveratrol, and can increase the bacterial abundance of lactobacilli while promoting the in-depth exertion of drug efficacy, and is used in combination with the overall acidic pH value of the care solution and the ability to resist miscellaneous bacteria, so that the care solution of the present invention is friendly to lactobacilli; catechu stops bleeding and promotes tissue regeneration, and is used in combination with calamine to synergistically enhance the effect of astringing and astringing sores, and promotes wound healing; dragon's blood has a relatively broad-spectrum antifungal and anti-inflammatory effect; calamine can absorb wound secretion, and has the effects of astringency, protection, sedation and itching.

[0016] The temperature of the reduced pressure distillation of the present invention not only removes ethanol as much as possible, but also reduces the destruction and loss of active components such as volatile oils; the ethanol immersion process of the present invention takes into account the difficulty of infiltration of medicinal materials and the crushing efficiency of the subsequent flash extraction, which not only fully infiltrates the medicinal materials to improve the flash extraction effect, but also avoids the loss and deterioration of active substances in the medicinal materials under long-term high humidity. The above-mentioned components of the present invention, under the unique process preparation and proportioning of the present invention, jointly form the hemostatic-anti-inflammatory-analgesic-tissue-generating system of the present invention, including the synergy of drug compatibility and the coordination of system stability. It should be noted that the process parameters and drug proportions of the present invention are not obtained by simple experiments, and have certain randomness and creativity. The proportions of the components cannot only consider their respective effects, but also have an impact on the overall stability. DETAILED DESCRIPTION

[0017] In order to more clearly explain the overall concept of the present invention, the overall scheme of the present invention is described in detail in the form of embodiments below; in the following description, a large number of specific details are given to provide a more thorough understanding of the present invention; however, it is obvious to those skilled in the art that the present invention can be implemented without one or more of these details; in other examples, in order to avoid confusion with the present invention, some technical features known in the art are not described.

[0018] In the present invention, the flash extractor was purchased from Beijing Haifuda Technology Co., Ltd., with a power of 1800W, and 0.5kg was processed in batches at a time; the vacuum distiller was purchased from Zhengzhou Huachen Instrument Co., Ltd., model EXRE-1005. The water content of rhubarb, angelica dahurica, curcuma, knotweed, catechu and dragon's blood was 10%, all purchased from Bozhou Xuanji Pharmaceutical Co., Ltd., and the rhubarb was Sichuan rhubarb. Lactic acid with a content of 88% was purchased from Guangzhou Suixin Chemical Co., Ltd.; calamine powder was purchased from Bozhou Rongjutang Pharmaceutical Co., Ltd., 500 mesh powder.

[0019] Unless otherwise specified, all raw material components in the following examples can be purchased from commercial sources, the experimental instruments used are conventional laboratory experimental instruments, and the performance test methods are known in the art. The overall space environment is 25°C and the air humidity is 30%.

[0020] The preferred implementation is as follows: Embodiment 1: The female private parts care solution is prepared by the following method: Take 18% of rhubarb, 16% of angelica dahurica, 13% of curcuma, 10% of knotweed, 8% of catechu, 6% of dragon's blood, 4% of calamine powder and make up the rest of the mass fraction of pure water, the total mass of the above substances is 0.5kg, chop and pass through a 20-mesh sieve, add 80% ethanol with a mass of 9 times the mass of the above medicinal materials, immerse at 46°C for 12h, add a flash extractor, the speed is 4000r / min, extract for 40s and then filter through 200 mesh to obtain an extract; add 0.2 times the mass of pure water to the coarsely filtered extract, and then distill under reduced pressure at 72°C and a vacuum degree of 800mbar until no liquid flows out continuously, collect the remaining liquid, add 88% lactic acid to adjust the pH to 3.5 to obtain the female private parts care solution.

[0021] Embodiment 2-15: The only difference between Example 2 and Example 1 is that the mass fraction of rhubarb is 15%; The only difference between Example 3 and Example 1 is that the mass fraction of rhubarb is 20%; The only difference between Example 4 and Example 1 is that the mass fraction of Angelica dahurica is 14%; The only difference between Example 5 and Example 1 is that the mass fraction of Angelica dahurica is 18%; The only difference between Example 6 and Example 1 is that the mass fraction of Curcuma is 11%; The difference between Example 7 and Example 1 is that the mass fraction of Curcuma is 15%; The only difference between Example 8 and Example 1 is that the mass fraction of Polygonum cuspidatum is 7%; The only difference between Example 9 and Example 1 is that the mass fraction of Polygonum cuspidatum is 12%; The only difference between Example 10 and Example 1 is that the mass fraction of catechu is 6%; The only difference between Example 11 and Example 1 is that the mass fraction of catechu is 10%; The only difference between Example 12 and Example 1 is that the mass fraction of Dragon's Blood is 4%; The only difference between Example 13 and Example 1 is that the mass fraction of dragon's blood is 8%; The difference between Example 14 and Example 1 is that the mass fraction of calamine powder is 3%; The difference between Example 15 and Example 1 is only that, the mass fraction of calamine powder is 5%.

[0022] Comparative Examples 1-25: The only difference between Comparative Example 1 and Example 1 is that the mass fraction of rhubarb is 7%; The difference between Comparative Example 2 and Example 1 is that the mass fraction of rhubarb is 30%; The only difference between Comparative Example 3 and Example 1 is that the mass fraction of Angelica dahurica is 7%; The only difference between Comparative Example 4 and Example 1 is that the mass fraction of Angelica dahurica is 30%; The difference between Comparative Example 5 and Example 1 is that the mass fraction of Curcuma is 5%; The difference between Comparative Example 6 and Example 1 is that the mass fraction of Curcuma is 25%; The only difference between Comparative Example 7 and Example 1 is that the mass fraction of Polygonum cuspidatum is 3%; The only difference between Comparative Example 8 and Example 1 is that the mass fraction of Polygonum cuspidatum is 22%; The only difference between Comparative Example 9 and Example 1 is that the mass fraction of catechu is 3%; The difference between Comparative Example 10 and Example 1 is that the mass fraction of catechu is 20%; The difference between Comparative Example 11 and Example 1 is that the mass fraction of Dragon's Blood is 2%; The difference between Comparative Example 12 and Example 1 is that the mass fraction of Dragon's Blood is 18%; The difference between Comparative Example 13 and Example 1 is that the mass fraction of calamine powder is 1%; The difference between Comparative Example 14 and Example 1 is that the mass fraction of calamine powder is 15%; The difference between Comparative Example 15 and Example 1 is that the temperature of vacuum distillation is 60°C; The difference between Comparative Example 16 and Example 1 is that the temperature of vacuum distillation is 85°C; The difference between Comparative Example 17 and Example 1 is that rhubarb is replaced with angelica dahurica, curcuma, knotweed, catechu, dragon's blood and calamine powder in an amount equal to that in Example 1; The difference between Comparative Example 18 and Example 1 is that the angelica root is replaced with rhubarb, curcuma, knotweed, catechu, dragon's blood and calamine powder of the same mass ratio as Example 1; The difference between Comparative Example 19 and Example 1 is that Curcuma is replaced with rhubarb, angelica dahurica, knotweed, catechu, dragon's blood and calamine powder of the same mass ratio as Example 1; The difference between Comparative Example 20 and Example 1 is that the knotweed is replaced with rhubarb, angelica dahurica, curcuma, catechu, dragon's blood and calamine powder of the same mass ratio as Example 1; The difference between Comparative Example 21 and Example 1 is that catechu is replaced with rhubarb, angelica dahurica, curcuma, knotweed, dragon's blood and calamine powder of the same mass ratio as Example 1; The difference between Comparative Example 22 and Example 1 is that the dragon's blood is replaced with rhubarb, angelica dahurica, curcuma, knotweed, catechu and calamine powder of the same mass ratio as Example 1; The difference between Comparative Example 23 and Example 1 is that calamine powder is replaced with rhubarb, angelica dahurica, curcuma, knotweed, catechu and dragon's blood of the same mass ratio as Example 1; The difference between Comparative Example 24 and Example 1 is that the female private parts care solution is replaced with an equal mass of 4% erythromycin lotion; The only difference between Comparative Example 25 and Example 1 is that the female private parts care solution is replaced with pure water of equal mass.

[0023] A total of 40-year-old female volunteers with obvious skin damage on the vulva and vagina were recruited. The sampling density of vaginal lactobacilli was basically the same in this experiment, and the initial sampling value was 32×10 6 cfu / g; The method of using the female private parts care solution of the present invention on the above volunteers is as follows: use warm water to clean the affected area and gently dry it, use a sterile cotton swab to dip the female private parts care solution of the present invention and evenly apply it to the affected area, with a dosage of 10 g each time, and use it 3 times a day.

[0024] After two weeks, 3 g of secretions were sampled from the vaginal wall using a tampon to detect the density of lactobacilli. The density of lactobacilli was detected according to section 6.2.3.4 of GB 4789.35-2016, the total number of Lactobacilli was detected and the density of lactobacilli was calculated. The higher the density of lactobacilli, the more friendly it is to lactobacilli.

[0025] After the last dose of the medicine each day, check by touch for any abnormal pain, and observe whether the skin is red, swollen, ulcerated, or cracked to determine whether the private skin has healed, and record the number of days to healing. The fewer the number of days to healing, the better the effect of promoting skin healing.

[0026] The results of the test are shown in Table 1. The density of lactobacilli is 10 6 cfu / g, rounded to the integer; the number of days for skin healing is rounded to the integer.

[0027] Table 1: Test results of Lactobacillus density and days of skin healing of volunteers in each example:

[0028] It can be seen from the data in Table 1 that, compared with other examples, the female private parts care solution and preparation method thereof of the embodiments of the present invention, especially Example 1 of the present invention, have the highest density of lactobacilli and the shortest number of days for skin healing of the corresponding volunteers at the same dosage of the liquid; that is, the female private parts care solution obtained by the present invention, especially Example 1 of the present invention, is friendly to lactobacilli and promotes skin healing.

[0029] The above description is only an embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A method for preparing a female private parts care solution, characterized in that: The preparation method of the female private parts care solution comprises the following steps: Take 15-20% of rhubarb, 14-18% of angelica dahurica, 11-15% of curcuma, 7-12% of knotweed, 6-10% of catechu, 4-8% of dragon's blood, 3-5% of calamine powder and make up the rest of the mass fraction of pure water, the total mass of the above substances is 0.5kg, cut and pass through a 20-mesh sieve, add 80% ethanol with a mass of 9 times the mass of the above medicinal materials, immerse at 46°C for 12h, add a flash extractor, the speed is 4000r / min, extract for 40s and then filter through 200 mesh to obtain an extract; add 0.2 times the mass of pure water to the extract, and then distill under reduced pressure at 72°C and a vacuum degree of 800mbar until no liquid flows out continuously, collect the remaining liquid, add 88% lactic acid to adjust the pH to 3.5 to obtain the female private parts care solution.

2. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the rhubarb is 18%.

3. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the Angelica dahurica is 16%.

4. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the turmeric is 13%.

5. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the knotweed is 10%.

6. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the catechu is 8%.

7. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the dragon's blood is 6%.

8. The method for preparing the female private parts care solution according to claim 1, characterized in that: The mass fraction of the calamine powder is 4%.

9. A female private parts care solution prepared by the method for preparing the female private parts care solution according to any one of claims 1 to 8.

Images