Post-art medical repair mask with soothing and anti-inflammatory effects and preparation method of post-art medical repair mask

Abstract

The invention discloses a medical post-art repair mask with soothing and anti-inflammatory effects and a preparation method of the medical post-art repair mask. The medical post-art repair mask comprises a medical post-art repair mask liquid and a mask base material, the mass ratio of the mask base material to the repairing mask liquid is 1: (2-5); the repairing mask liquid is prepared from rice fermentation liquor, glucan and micro-protein. The preparation method comprises the following steps: S1, preparing mask liquid; and S2, immersing the mask base material into the mask liquid to obtain the medical post-art repair mask with the soothing and anti-inflammatory effects. According to the medical post-art repair mask with the soothing and anti-inflammatory effects and the preparation method thereof, the repair and soothing and anti-inflammatory effects can be taken into account, and after the mask is used, cooling and detumescence can be rapidly achieved, and local inflammatory reaction of skin can be relieved; according to the invention, the soothing and anti-inflammatory effects can be improved, and the repairing effects of soothing, anti-inflammatory and rapid calming are achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and relates to a facial mask, in particular to a medical post-aesthetic repair facial mask with soothing and anti-inflammatory effects and a preparation method thereof. Background Art

[0002] With the improvement of economic level and the promotion of consumers' demand for beauty, the medical beauty market has grown rapidly. Medical cosmetology refers to the use of surgery, drugs, medical devices and other medical techniques to repair and reconstruct people's appearance and body parts through the principle of "destroying first and then rebuilding". However, after some medical beauty operations such as plastic surgery, microneedle, and laser, the skin barrier function is easily damaged, and symptoms such as swelling, redness, and inflammation appear. If skin inflammation is not subsided in time, problems such as redness, swelling, darkening, and inflammatory aging will occur. Therefore, using a facial mask after medical beauty can provide a healing environment for the skin, isolate external stimuli, thereby reducing facial skin discomfort and accelerating wound healing.

[0003] At present, the products on the market have the following main problems: (1) Some products have a single effective ingredient, such as Chinese invention patent CN202111042284.7, which only has a soothing effect but cannot reduce skin inflammatory reactions; (2) The soothing and anti-inflammatory effects are slow to take effect, such as Chinese invention patent CN202111044257.3, which requires long-term use of the product to have a significant effect, and cannot quickly relieve the discomfort of skin redness, swelling, pain, heat, etc. caused by acute inflammation after medical aesthetics.

[0004] In view of this, there is an urgent need to design a new repairing facial mask so as to overcome at least some of the above-mentioned defects of the existing repairing facial masks. Summary of the invention

[0005] The present invention provides a medical post-art repair facial mask with soothing and anti-inflammatory effects and a preparation method thereof, which can take into account both the repair and soothing and anti-inflammatory effects. After use, it can quickly reduce temperature and swelling, alleviate local inflammatory reactions of the skin, and improve the soothing and anti-inflammatory effects, thereby achieving soothing, anti-inflammatory, and rapid calming repair effects.

[0006] To solve the above technical problem, according to one aspect of the present invention, the following technical solution is adopted:

[0007] A medical post-aesthetic repair mask with soothing and anti-inflammatory effects, the medical post-aesthetic repair mask comprising: a medical post-aesthetic repair mask liquid and a mask base material;

[0008] The mass ratio of the mask base material to the repairing mask liquid is 1:(10-20); the repairing mask liquid comprises functional raw materials, and the functional raw materials comprise: rice fermentation liquid, glucan and microprotein.

[0009] As an embodiment of the present invention, the mass of the effective raw materials in the repairing facial mask liquid accounts for 0.3 to 20% of the total mass of the medical aesthetic repairing facial mask.

[0010] As an embodiment of the present invention, the mass of the rice fermentation liquid accounts for 0.1-10% of the total mass of the medical aesthetic repair mask, and the rice fermentation liquid is a product formed by fermenting selected natural rice and edible grade yeast;

[0011] The mass of the dextran accounts for 0.1-5% of the total mass of the medical aesthetic repair mask, and the dextran is a natural ingredient transformed from marine tidal flat microorganisms;

[0012] The mass of the microprotein accounts for 0.1-5% of the total mass of the medical cosmetic repair mask. The microprotein is a mini growth factor obtained by a polypeptide solid phase synthesis method.

[0013] As an embodiment of the present invention, the medical cosmetic post-repair facial mask liquid comprises: raw material combination A, raw material combination B, raw material combination C, raw material combination D and raw material combination E;

[0014] The raw material combination A comprises: a thickener in an amount of 0.05 to 1 wt %, a skin conditioner in an amount of 0.05 to 1 wt %, a moisturizer in an amount of 2 to 10 wt % and water;

[0015] The raw material combination B comprises: a skin conditioning agent in an amount of 0.2 to 1 wt%, an emulsifier in an amount of 0.1 to 1 wt%, and an excipient in an amount of 0.5 to 5 wt%;

[0016] The raw material combination C comprises: a pH value regulator in an amount of 0.01 to 1 wt%;

[0017] The raw material combination D comprises: a fragrance in an amount of 0.01 to 0.1 wt% and a preservative in an amount of 0.01 to 0.1 wt%;

[0018] The raw material combination E comprises: functional raw materials with a content of 0.3-20wt%.

[0019] As an embodiment of the present invention, the thickener includes at least one of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer.

[0020] As an embodiment of the present invention, the skin conditioning agent includes at least one of sodium hyaluronate, allantoin or cetyl alcohol; the moisturizing agent includes at least one of glycerin, shea butter or ethylhexylglycerin;

[0021] The emulsifier includes at least one of cetearyl glucoside (and) cetearyl alcohol; the excipient includes squalane; the pH adjuster includes at least one of sodium citrate, triethanolamine, and arginine; the fragrance includes essence; and the preservative includes phenoxyethanol and / or parabens.

[0022] According to another aspect of the present invention, the following technical solution is adopted: a method for preparing a medical cosmetic repair mask, the preparation method comprising:

[0023] Step S1, facial mask liquid preparation step;

[0024] a. Water phase: Place water in a container with a stirring device and stir, fully wet and mix the other parts of the raw material combination A except water, add them into the water, stir until completely dissolved, and heat to 75-80°C;

[0025] b. Oil phase; mix the raw material combination B, heat to 75-80°C, and stir until completely dissolved;

[0026] c. Emulsification: Add the mixture of step b to the aqueous phase of step a, stir at 20 to 40 rpm and homogenize at 2000 to 4000 rpm for 3 to 10 minutes;

[0027] d. Add raw material combination C, stir at 20-40 rpm and homogenize at 2000-4000 rpm for 1-10 minutes; stir and cool to 35-55°C;

[0028] e. Add raw material combination D, stir at 20-40 rpm and homogenize at 2000-4000 rpm for 1-10 minutes, and filter sterilize by filtration;

[0029] f. After the temperature drops to 35-38°C, add the raw material combination E, stir at 20-40rpm and homogenize at 2000-4000rpm for 1-10 minutes to obtain the desired facial mask liquid;

[0030] Step S2, immersing the mask substrate in the mask liquid to obtain a post-aesthetic repair mask with soothing and anti-inflammatory effects;

[0031] The raw material combination A comprises: a thickener in an amount of 0.05 to 1 wt %, a skin conditioner in an amount of 0.05 to 1 wt %, a moisturizer in an amount of 2 to 10 wt % and water;

[0032] The raw material combination B comprises: a skin conditioning agent in an amount of 0.2 to 1 wt%, an emulsifier in an amount of 0.1 to 1 wt%, and an excipient in an amount of 0.5 to 5 wt%;

[0033] The raw material combination C comprises: a pH value regulator in an amount of 0.01 to 1 wt%;

[0034] The raw material combination D comprises: a fragrance in an amount of 0.01 to 0.1 wt% and a preservative in an amount of 0.01 to 0.1 wt%;

[0035] The raw material combination E comprises: functional raw materials with a content of 0.3-20wt%.

[0036] As an embodiment of the present invention, step S2 further includes: filtering and sterilizing before packaging, detecting the bacterial content, and performing quality control on toxins and immunogenicity.

[0037] As an embodiment of the present invention, the thickener includes at least one of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer.

[0038] As an embodiment of the present invention, the skin conditioning agent includes at least one of sodium hyaluronate, allantoin or cetyl alcohol; the moisturizing agent includes at least one of glycerin, shea butter or ethylhexylglycerin;

[0039] The emulsifier includes at least one of cetearyl glucoside (and) cetearyl alcohol; the excipient includes squalane; the pH adjuster includes at least one of sodium citrate, triethanolamine, and arginine; the fragrance includes essence; and the preservative includes phenoxyethanol and / or parabens.

[0040] The beneficial effects of the present invention are: the medical post-art repair mask with soothing and anti-inflammatory effects and the preparation method thereof proposed in the present invention can take into account both the repair and soothing and anti-inflammatory effects, and can quickly reduce temperature and swelling after use, and alleviate local inflammatory reactions of the skin; the present invention can improve the soothing and anti-inflammatory effects, and achieve soothing, anti-inflammatory, and rapid calming repair effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1 The present invention is a flowchart of a method for preparing a Chinese medicine post-aesthetic repair mask according to an embodiment of the present invention. DETAILED DESCRIPTION

[0042] The preferred embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0043] In order to further understand the present invention, preferred embodiments of the present invention are described below in conjunction with examples. However, it should be understood that these descriptions are only for further illustrating the features and advantages of the present invention, rather than limiting the claims of the present invention.

[0044] The description in this section is only for several typical embodiments, and the present invention is not limited to the scope of the embodiments. The same or similar prior art means and some technical features in the embodiments are mutually replaced within the scope of the present invention.

[0045] The description of the steps in each embodiment in the specification is only for the convenience of explanation, and the implementation method of the present application is not limited by the order of implementation of the steps.

[0046] The present invention discloses a medical post-aesthetic repair mask with soothing and anti-inflammatory effects, the medical post-aesthetic repair mask comprising: a medical post-aesthetic repair mask liquid and a mask base material; the mass ratio of the mask base material to the repair mask liquid is 1: (10-20); the repair mask liquid comprises functional raw materials, the functional raw materials comprising: rice fermentation liquid, glucan and microprotein. In one embodiment, the mass of the functional raw materials in the repair mask liquid accounts for 0.3-20% of the total mass of the medical post-aesthetic repair mask.

[0047] The mass of the rice fermentation liquid can account for 0.1-10% of the total mass of the medical aesthetic repair mask. The rice fermentation liquid is a product formed by fermenting selected natural rice and edible-grade yeast; the mass of the glucan accounts for 0.1-5% of the total mass of the medical aesthetic repair mask. The glucan is a natural ingredient transformed from marine tidal flat microorganisms; the mass of the microprotein accounts for 0.1-5% of the total mass of the medical aesthetic repair mask. The microprotein is a mini growth factor obtained by a polypeptide solid phase synthesis method.

[0048] In one embodiment of the present invention, the medical aesthetic repair mask liquid comprises: raw material combination A, raw material combination B, raw material combination C, raw material combination D and raw material combination E. The raw material combination A comprises: a thickener with a content of 0.05-1wt% (accounting for 100% of the mass of the medical aesthetic repair mask, the same below), a skin conditioner with a content of 0.05-1wt%, a moisturizer with a content of 2-10wt% and water; the raw material combination B comprises: a skin conditioner with a content of 0.2-1wt%, an emulsifier with a content of 0.1-1wt%, and an esterifying agent with a content of 0.5-5wt%; the raw material combination C comprises: a pH value regulator with a content of 0.01-1wt%; the raw material combination D comprises: a fragrance with a content of 0.01-0.1wt% and a preservative with a content of 0.01-0.1wt%; the raw material combination E comprises: a functional raw material with a content of 0.3-20wt%.

[0049] In one embodiment, the thickener includes at least one of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylates / C10-30 alkyl acrylate crosspolymer, and ammonium acryloyldimethyl taurate / VP copolymer. The skin conditioner includes at least one of sodium hyaluronate, allantoin, or cetyl alcohol; the moisturizer includes at least one of glycerin, shea butter, or ethylhexylglycerin. The emulsifier includes at least one of cetearyl glucoside (and) cetearyl alcohol; the excipient includes squalane; the pH adjuster includes at least one of sodium citrate, triethanolamine, and arginine; the fragrance includes essence; and the preservative includes phenoxyethanol and / or parabens.

[0050] Rice fermented liquid is made from selected high-quality rice fermented by edible yeast (Saccharomyces veronae). It contains more than 60 ingredients, such as α-KG, adenosine, nucleotides, amino acids, polysaccharides and minerals. It has good diffusion and permeability in skin care products, can quickly penetrate deep into the skin, and moisturize for a long time. In addition, the ingredient α-KG has been proven to promote keratinocyte proliferation, enhance skin barrier function, increase the expression of skin water retention and barrier-related genes: FLG, SPT and IVL, and help soothe and strengthen the skin barrier. The ingredient adenosine, as the main raw material and intermediate of biological metabolism, can provide energy for cells, inhibit oxygen free radicals, promote skin cell metabolism, regulate MMP1 synthesis, inhibit its decomposition of collagen and elastic fibers, enhance skin firmness, and promote skin repair and enhancement. The ingredient cytosine is an important component of ribonucleic acid in living organisms and participates in many reactions in living organisms. It is currently widely used in the fields of medicine and food, and has anti-inflammatory, antibacterial and antiviral effects. Studies have also shown that it has a protective effect against UVB damage, and can absorb ultraviolet rays to degrade and thus resist ultraviolet rays. It can promote cell growth, reduce the depth of wrinkles, and play a role in skin enhancement and repair. Glucan is a polysaccharide widely found in microorganisms, tannins and higher plants. It can bind to receptors (Dectin-1) on the cell membrane to increase the activity of T cells (T-lymphocyte) and B cells (B-lymphocyte), maintain the balance of the skin's immune system, and play an anti-inflammatory role. In addition, due to its large molecular weight, it is easy to form a barrier on the surface of the skin to achieve a moisturizing effect; microprotein promotes skin tolerance through TGF-β. Because its molecular weight is less than 500 Daltons, it has good epidermal permeability and can achieve a rapid soothing effect.

[0051] The present invention further discloses a method for preparing a medical cosmetic repair mask. Figure 1 This is a flow chart of a method for preparing a Chinese medicine post-aesthetic repair mask according to an embodiment of the present invention; please refer to Figure 1 , the preparation method comprises:

[0052] [Step S1] Facial mask liquid preparation step;

[0053] a. Water phase: Place water in a container with a stirring device and stir, fully wet and mix the other parts of the raw material combination A except water, add them into the water, stir until completely dissolved, and heat to 75-80°C (such as 75°C, 78°C, 80°C);

[0054] b. Oil phase; mix the raw material combination B, heat to 75-80°C (eg, 75°C, 78°C, 80°C), and stir until completely dissolved;

[0055] c. Emulsification: Add the mixture of step b to the aqueous phase of step a, stir at 30 rpm (the stirring speed may be 20-40 rpm or other speeds, the same below) and homogenize at 3000 rpm (the average speed may be 2000-4000 rpm, the same below) for 5 minutes (the homogenization time may be 3-10 minutes);

[0056] d. Add raw material C, stir at 30 rpm and homogenize at 3000 rpm for 3 minutes (homogenization time can be 1 to 10 minutes); stir and cool to 45 ° C (can be cooled to 35 to 55 ° C);

[0057] e. Add raw material combination D, stir at 30 rpm and homogenize at 3000 rpm for 3 minutes (the homogenization time can be 3 to 10 minutes), and filter sterilize by filtration;

[0058] All the above steps are strictly controlled for sterility;

[0059] f. After the temperature is cooled to 35-38°C (eg, 35°C, 37°C, 38°C), add the raw material combination E, stir at 30rpm and homogenize at 3000rpm for 3 minutes (the homogenization time may be 3-10 minutes), and the desired facial mask liquid is obtained;

[0060] Among them, the raw material combination A includes: a thickener with a content of 0.05-1wt%, a skin conditioner with a content of 0.05-1wt%, a moisturizer with a content of 2-10wt% and water; the raw material combination B includes: a skin conditioner with a content of 0.2-1wt%, an emulsifier with a content of 0.1-1wt%, and an excipient with a content of 0.5-5wt%; the raw material combination C includes: a pH regulator with a content of 0.01-1wt%; the raw material combination D includes: a fragrance with a content of 0.01-0.1wt% and a preservative with a content of 0.01-0.1wt%; the raw material combination E includes: a functional raw material with a content of 0.3-20wt%.

[0061] The thickener includes at least one of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer. The skin conditioner includes at least one of sodium hyaluronate, allantoin or cetyl alcohol; the moisturizer includes at least one of glycerin, shea butter or ethylhexylglycerin. The emulsifier includes at least one of cetearyl glucoside (and) cetearyl alcohol; the excipient includes squalane; the pH adjuster includes at least one of sodium citrate, triethanolamine, and arginine; the fragrance includes essence; the preservative includes phenoxyethanol and / or parabens.

[0062] [Step S2] The mask base material is immersed in the mask liquid to obtain a medical post-aesthetic repair mask with soothing and anti-inflammatory effects.

[0063] In one embodiment of the present invention, step S2 further includes: filtering and sterilizing before packaging, detecting the bacterial content, and performing quality control on toxins and immunogenicity.

[0064] Example 1

[0065] A medical post-aesthetic repair mask with soothing and anti-inflammatory effects, which contains a mask liquid with a mass percentage (mass percentage of the medical post-aesthetic repair mask) of 95% based on the total weight of the composition, wherein the soothing and anti-inflammatory ingredients are 20wt%, including 10wt% of rice fermentation liquid, 5wt% of glucan, and 5wt% of microprotein (all percentages of the total mass of the medical post-aesthetic repair mask, the same below). The preparation method of the medical post-aesthetic repair mask in this embodiment follows the preparation steps and control parameters mentioned in the above description of the preparation method.

[0066] Example 2

[0067] A medical post-art repair mask with soothing and anti-inflammatory effects, comprising a mask liquid with a mass proportion of 95%, based on the total weight of the composition, wherein the mask liquid contains 10wt% of soothing and anti-inflammatory ingredients, including 5wt% of rice fermentation liquid, 2.5wt% of glucan, and 2.5wt% of microprotein. The preparation method of the medical post-art repair mask in this embodiment follows the preparation steps and control parameters mentioned in the above description of the preparation method.

[0068] Example 3

[0069] A medical post-art repair mask with soothing and anti-inflammatory effects, comprising a mask liquid with a mass proportion of 95%, based on the total weight of the composition, wherein the mask liquid contains 17.5wt% of soothing and anti-inflammatory ingredients, including 10wt% of rice fermentation liquid, 5wt% of glucan, and 2.5wt% of microprotein. The preparation method of the medical post-art repair mask in this embodiment follows the preparation steps and control parameters mentioned in the above description of the preparation method.

[0070] Example 4

[0071] A medical post-art repair mask with soothing and anti-inflammatory effects, comprising a mask liquid with a mass proportion of 95%, based on the total weight of the composition, wherein the mask liquid contains 17.5wt% of soothing and anti-inflammatory ingredients, including 10wt% of rice fermentation liquid, 2.5wt% of glucan, and 5wt% of microprotein. The preparation method of the medical post-art repair mask in this embodiment follows the preparation steps and control parameters mentioned in the above description of the preparation method.

[0072] Example 5

[0073] A medical post-art repair mask with soothing and anti-inflammatory effects, comprising a mask liquid with a mass proportion of 95%, based on the total weight of the composition, wherein the mask liquid contains 20wt% of soothing and anti-inflammatory ingredients, including 10wt% of rice fermentation liquid, 5wt% of glucan, and 5wt% of microprotein. The preparation method of the medical post-art repair mask in this embodiment follows the preparation steps and control parameters mentioned in the above description of the preparation method.

[0074] Comparative Example 1

[0075] Control Example 1 provides a medical post-aesthetic repair facial mask with soothing and anti-inflammatory effects. The difference from Example 1 is that the proportion of soothing and anti-inflammatory ingredients in the preparation process is different, and it contains 15wt% rice fermentation liquid, 2.5wt% glucan, and 2.5wt% microprotein.

[0076] Comparative Example 2

[0077] Control Example 2 provides a medical post-aesthetic repair facial mask with soothing and anti-inflammatory effects. The difference from Example 1 is that the proportion of soothing and anti-inflammatory ingredients in the preparation process is different, and it contains 10wt% rice fermentation liquid, 7.5wt% glucan, and 2.5wt% microprotein.

[0078] Comparative Example 3

[0079] Control Example 3 provides a medical post-aesthetic repair facial mask with soothing and anti-inflammatory effects. The difference from Example 1 is that the proportion of soothing and anti-inflammatory ingredients in the preparation process is different, and it contains 5wt% rice fermentation liquid, 10wt% glucan, and 5wt% microprotein.

[0080] Comparative Example 4

[0081] Control Example 4 is a commercially available facial mask liquid that claims to have soothing effects and is an alternative to the repairing facial mask liquid. The product claims that the effective ingredients are yeast / rice fermentation product filtrate, dextran, and Chondrus crispus extract. After testing, the product contains 3wt% of yeast / rice fermentation product filtrate, 1wt% of dextran, and 0.1wt% of Chondrus crispus extract.

[0082] Table 1 Components of each embodiment and comparative example

[0083]

[0084]

[0085] Characterization data and effect data of the products of the embodiments and comparative examples

[0086] 1. Animal experiment-scratching inhibition

[0087] Experimental method: Tail vein injection of dextran

[0088] Test model: 10 guinea pigs per group, half male and half female, weighing 250-300g

[0089] Table 2 Guinea pig scratching inhibition test results (expressed as mean ± SD)

[0090]

[0091] The results of the guinea pig scratching inhibition test showed (as shown in Table 2) that the five facial mask liquid examples all had significant antipruritic effects, that is, soothing effects, and were better than the control examples with the same concentrations, and were close to the effects of the compound dexamethasone acetate cream.

[0092] 2. Animal experiments-histamine tolerance

[0093] Test method: Histamine was applied to the back of guinea pigs

[0094] Test model: 10 guinea pigs per group, half male and half female, weighing 250-300g

[0095] Table 3 Guinea pig histamine tolerance test

[0096]

[0097]

[0098] The results of guinea pig histamine tolerance show (as shown in Table 3) that the examples with a concentration of 1% significantly increased the histamine tolerance of guinea pigs, had significant soothing and antipruritic effects, and the effects were better than those of the control examples with the same concentration, and were close to those of the compound dexamethasone acetate cream.

[0099] 3. Antioxidant test

[0100] Test method: 《T / SHRH 006-2018》

[0101] The DPPH free radical scavenging rates of the examples (expressed as mean ± SD) are shown in Table 4.

[0102] Table 4 DPPH free radical scavenging rate comparison table of the embodiment

[0103] Example 1 2 3 4 5 Clearance rate (%) 91.2±3.2 85.6±2.1 88.7±3.4 87.2±3.6 90.5±2.8

[0104] The DPPH free radical scavenging rates of the control examples (expressed as mean ± SD) are shown in Table 5.

[0105] Table 5 DPPH free radical scavenging rate comparison table of control examples

[0106] Comparison Example 1 2 3 4 Clearance rate (%) 62.3±2.2 63.1±2.1 60.7±3.4 58.3±3.6

[0107] The results of the DPPH free radical scavenging test showed that all of the five examples had good antioxidant activity, and were significantly higher than those of all the control examples.

[0108] 4. Human trials

[0109] Test method: Four 3cm×3cm skins were randomly marked on the inner side of the two arms of the test subjects as test areas, and were marked as blank group, negative control group, Example 1 group, and Control group 1 group. Transparent tape was used to tear the test areas of the experimental group and the negative control group respectively. Each area was repeatedly torn 10 times. A 3cm×3cm non-woven fabric was soaked in a 10mg / mL histamine solution, taken out, and applied to two areas, and peeled off after 10 minutes. After the skin was dry, the sample (1% aqueous solution of Example 1 and Control Example 1) and the control were applied. The negative control used physiological saline, and the amount used was 2mg / cm2. The EI value of the skin erythema index of the test site 30min, 60min, and 120min after the sample was applied was obtained using a hemoglobin tester.

[0110] Subjects: 30 healthy volunteers, 15 males and 15 females, aged 18 to 50.

[0111] The skin erythema index EI values ​​(expressed as mean ± SD) are shown in Table 6.

[0112] Table 6 Comparison of skin erythema index EI values

[0113] Blank group Negative control Example 1 Comparative Example 1 30min 123.7±5.2 236.6±11.1 207.0±13.4 219.0±13.6 60min 125.6±3.1 225.9±12.0 185.9±9.8 201.5±18.9 120min 127.6±4.2 207.9±10.2 170.2±7.2 178.9±11.1

[0114] 5.TEWL(g / m 2 / h) Transepidermal water loss test

[0115] The transepidermal water loss (TWEL) is accurately measured using the non-invasive device TEWL (Derma l ab Combo). If the TWEL decreases significantly before and after the use of the test product, it means that the skin barrier has been restored and the product has a repairing effect.

[0116] Table 7 Analysis of changes in TWEL values ​​of subjects' skin over time

[0117] Time Averages and standard deviations Variationpercentage BL 17.27±4.23 - W1 17.14±5.21 -0.75％ W2 14.78±3.23 -14.42％ W4 13.67±4.32 -20.84％

[0118] As can be seen from Table 7, the subjects' skin TWEL value decreased significantly by 14.42% after using the product for 2 weeks; after using the product for 4 weeks, TWEL continued to decrease, significantly decreasing by 20.84%. The above results indicate that under the test conditions, the test product can significantly reduce the skin TWEL value and has a repairing effect.

[0119] In summary, the medical post-art repair mask with soothing and anti-inflammatory effects and the preparation method thereof proposed in the present invention can take into account both repair and soothing and anti-inflammatory effects. After use, it can quickly reduce temperature and swelling, and alleviate local inflammatory reactions of the skin; the present invention can improve the soothing and anti-inflammatory effects, and achieve soothing, anti-inflammatory, and rapid calming repair effects.

[0120] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0121] The description and application of the present invention here are illustrative, and it is not intended to limit the scope of the present invention to the above-mentioned embodiments. The effects or advantages involved in the embodiments may not be embodied in the embodiments due to interference from various factors, and the description of the effects or advantages is not used to limit the embodiments. The deformation and change of the embodiments disclosed here are possible, and the replacement of the embodiments and the various equivalent parts are well known to those of ordinary skill in the art. It should be clear to those skilled in the art that the present invention can be implemented in other forms, structures, arrangements, proportions, and with other components, materials and parts without departing from the spirit or essential features of the present invention. Other deformations and changes can be made to the embodiments disclosed here without departing from the scope and spirit of the present invention.

Claims

1. A medical post-aesthetic repair mask with soothing and anti-inflammatory effects, characterized in that: The post-medical aesthetic repair mask comprises: a post-medical aesthetic repair mask liquid and a mask base material; The mass ratio of the mask base material to the medical aesthetic post-repair mask liquid is 1:(10-20); the medical aesthetic post-repair mask liquid includes functional raw materials, and the functional raw materials include: rice fermentation liquid, glucan and microprotein.

2. The medical post-aesthetic repair mask with soothing and anti-inflammatory effects according to claim 1, characterized in that: The weight of the effective raw materials in the repairing facial mask liquid accounts for 0.3-20% of the total weight of the medical cosmetic repairing facial mask.

3. The medical post-aesthetic repair mask with soothing and anti-inflammatory effects according to claim 1, characterized in that: The mass of the rice fermentation liquid accounts for 0.1-10% of the total mass of the medical cosmetic repair mask, and the rice fermentation liquid is a product formed by fermenting selected natural rice and edible-grade yeast; The mass of the dextran accounts for 0.1-5% of the total mass of the medical aesthetic repair mask, and the dextran is a natural ingredient transformed from marine tidal flat microorganisms; The mass of the microprotein accounts for 0.1-5% of the total mass of the medical cosmetic repair mask. The microprotein is a mini growth factor obtained by a polypeptide solid phase synthesis method.

4. The medical post-aesthetic repair mask with soothing and anti-inflammatory effects according to claim 1, characterized in that: The medical cosmetic post-repair facial mask liquid comprises: raw material combination A, raw material combination B, raw material combination C, raw material combination D and raw material combination E; The raw material combination A comprises: a thickener in an amount of 0.05 to 1 wt %, a skin conditioner in an amount of 0.05 to 1 wt %, a moisturizer in an amount of 2 to 10 wt % and water; The raw material combination B comprises: a skin conditioning agent in an amount of 0.2 to 1 wt%, an emulsifier in an amount of 0.1 to 1 wt%, and an excipient in an amount of 0.5 to 5 wt%; The raw material combination C comprises: a pH value regulator in an amount of 0.01 to 1 wt%; The raw material combination D comprises: a fragrance in an amount of 0.01 to 0.1 wt% and a preservative in an amount of 0.01 to 0.1 wt%; The raw material combination E comprises: functional raw materials with a content of 0.3-20wt%.

5. The medical post-aesthetic repair mask with soothing and anti-inflammatory effects according to claim 4, characterized in that: The thickener includes at least one of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer.

6. The medical post-aesthetic repair mask with soothing and anti-inflammatory effects according to claim 4, characterized in that: The skin conditioning agent includes at least one of sodium hyaluronate, allantoin or cetyl alcohol; the moisturizing agent includes at least one of glycerin, shea butter or ethylhexylglycerin; The emulsifier includes at least one of cetearyl glucoside (and) cetearyl alcohol; the excipient includes squalane; the pH adjuster includes at least one of sodium citrate, triethanolamine, and arginine; the fragrance includes essence; and the preservative includes phenoxyethanol and / or parabens.

7. A method for preparing a medical cosmetic repair mask, characterized in that: The preparation method comprises: Step S1, facial mask liquid preparation step; a. Water phase: Place water in a container with a stirring device and stir, fully wet and mix the other parts of the raw material combination A except water, add them into the water, stir until completely dissolved, and heat to 75-80°C; b. Oil phase; mix the raw material combination B, heat to 75-80°C, and stir until completely dissolved; c. Emulsification: Add the mixture of step b to the aqueous phase of step a, stir at 20 to 40 rpm and homogenize at 2000 to 4000 rpm for 3 to 10 minutes; d. Add raw material combination C, stir at 20-40 rpm and homogenize at 2000-4000 rpm for 1-10 minutes; stir and cool to 35-55°C; e. Add raw material combination D, stir at 20-40 rpm and homogenize at 2000-4000 rpm for 1-10 minutes, and filter sterilize by filtration; f. After the temperature drops to 35-38°C, add the raw material combination E, stir at 20-40rpm and homogenize at 2000-4000rpm for 1-10 minutes to obtain the desired facial mask liquid; Step S2, immersing the mask substrate in the mask liquid to obtain a post-aesthetic repair mask with soothing and anti-inflammatory effects; The raw material combination A comprises: a thickener in an amount of 0.05 to 1 wt %, a skin conditioner in an amount of 0.05 to 1 wt %, a moisturizer in an amount of 2 to 10 wt % and water; The raw material combination B comprises: a skin conditioning agent in an amount of 0.2 to 1 wt%, an emulsifier in an amount of 0.1 to 1 wt%, and an excipient in an amount of 0.5 to 5 wt%; The raw material combination C comprises: a pH value regulator in an amount of 0.01 to 1 wt%; The raw material combination D comprises: a fragrance in an amount of 0.01 to 0.1 wt% and a preservative in an amount of 0.01 to 0.1 wt%; The raw material combination E comprises: functional raw materials with a content of 0.3-20wt%.

8. The method for preparing the post-aesthetic repair mask according to claim 7, characterized in that: Step S2 further includes: filtering and sterilizing before packaging, detecting the bacterial content, and performing quality control on toxins and immunogenicity.

9. The method for preparing the post-aesthetic repair mask according to claim 7, characterized in that: The thickener includes at least one of sodium acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, hydroxyethyl cellulose, carbomer, acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and ammonium acryloyldimethyl taurate / VP copolymer.

10. The method for preparing the post-aesthetic repair mask according to claim 7, characterized in that: The skin conditioning agent includes at least one of sodium hyaluronate, allantoin or cetyl alcohol; the moisturizing agent includes at least one of glycerin, shea butter or ethylhexylglycerin; The emulsifier includes at least one of cetearyl glucoside (and) cetearyl alcohol; the excipient includes squalane; the pH adjuster includes at least one of sodium citrate, triethanolamine, and arginine; the fragrance includes essence; and the preservative includes phenoxyethanol and / or parabens.

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