Stereotactic radiotherapy equipment for realizing dose tracking and use method thereof

Abstract

The invention relates to stereotactic radiotherapy equipment for achieving dose tracking and a using method thereof, and belongs to the technical field of radiotherapy equipment.The stereotactic radiotherapy equipment comprises a semicircular connecting piece, a dose tracking detection assembly, an accelerator assembly and a folding lifting mechanism, the interference caused by oblique incidence of the beam and the influence of inaccurate dosage are avoided; the dose tracking and detecting assembly is of a semi-annular structure and can follow a beam in real time to carry out full spherical irradiation, in addition, when the dose tracking system does not need to work or quality control testing is carried out, the dose tracking and detecting assembly is automatically folded to an initial position through the folding lifting mechanism, the dose tracking system is protected, meanwhile, space is saved, the treatment bed is convenient to place, and the treatment bed is convenient to use. Moreover, the quality control test is not affected, and the technical problem that the stereotactic radiotherapy equipment connected with the mechanical arm structure cannot collect the dosimetry information in the radiotherapy process in real time is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of radiotherapy equipment, and in particular to a stereotactic radiotherapy equipment for realizing dose tracking and a method for using the same. Background Art

[0002] Stereotactic Radiotherapy (SRT) is a high-precision radiotherapy technology used in the field of radiation oncology, which has shown excellent efficacy in the treatment of small tumors and targeted treatment of specific areas. SRT technology uses an advanced three-dimensional spatial positioning system to achieve precise control of radiation dose distribution, thereby protecting surrounding normal tissues to the greatest extent and reducing unnecessary damage to normal cells.

[0003] The professional advantages of SRT technology include: High spatial resolution: using high-precision image guidance technology to ensure the precise alignment of the radiation beam with the tumor target. Non-invasive treatment characteristics: avoiding the trauma of traditional surgery and providing patients with a gentler treatment method. Accuracy of dose control: by accurately calculating the radiation dose, efficient killing of tumor cells is achieved while minimizing damage to normal tissues. Treatment adaptability: suitable for a variety of tumor types, including but not limited to brain tumors, lung cancer, liver cancer, etc. Flexibility of treatment plan: the ability to customize personalized treatment plans based on the location of the tumor and the patient's anatomical structure.

[0004] At present, the structure of stereotactic radiotherapy treatment equipment is limited. The stereotactic radiotherapy treatment equipment with a mechanical arm structure in the prior art cannot realize the full-plane three-dimensional acquisition of dosimetric information during the patient's treatment process. Moreover, the stereotactic radiotherapy treatment equipment with a mechanical arm structure in the prior art cannot realize the dose distribution reconstruction during the non-public surface treatment process, and cannot obtain the dose changes of the target area and the organs at risk, and cannot protect the organs at risk and improve the coverage of the target area dose; in the prior art, the analysis of the patient's radiotherapy dose can only be carried out through the irradiation information obtained by the phantom simulation verification, and the dose information of the patient's actual treatment cannot be obtained. Summary of the invention

[0005] In view of the above problems, the present invention provides a stereotactic radiotherapy device for realizing dose tracking and a method of using the same. The present invention comprises a semi-annular connector, a dose tracking detection assembly, an accelerator assembly and a folding and lifting mechanism, wherein the dose tracking detection assembly is used to receive vertical irradiation of the beam to avoid interference caused by oblique incidence of the beam and the influence of inaccurate dose; the semi-annular structure allows the dose tracking detection assembly to follow the beam in real time for global irradiation. In addition, when the dose tracking system is not needed to work or quality control testing is performed, the dose tracking detection assembly is automatically retracted to the initial position through the folding and lifting mechanism, which protects the dose tracking system while saving space, facilitates the placement of the treatment bed, and does not affect the quality control test, thereby solving the technical problem that the stereotactic radiotherapy device connected to the mechanical arm structure cannot collect dosimetric information in real time during the radiotherapy process.

[0006] An object of the present invention is to provide a stereotactic radiotherapy device for achieving dose tracking, comprising:

[0007] A semi-annular connector 1, a dose tracking detection assembly 2, an accelerator assembly 3 and a folding and lifting mechanism 4;

[0008] The semi-annular connector 1 is respectively connected to the accelerator assembly 3 and the folding and lifting mechanism 4; the folding and lifting mechanism 4 is also connected to the dose tracking detection assembly 2;

[0009] In one embodiment of the present invention, the dose tracking detection assembly 2 is arranged on the upper side of the folding and lifting mechanism 4 in the horizontal direction;

[0010] Optionally, the middle position of the semi-annular connector 1 is connected to a robotic arm 5, and the robotic arm 5 controls the semi-annular bracket to rotate 360 ​​degrees according to treatment requirements, so that the dose tracking system can follow the beam in real time to perform global irradiation;

[0011] The semi-circular connector 1 is respectively connected to the accelerator assembly 3 and the folding and lifting mechanism 4. During the treatment process, the movement of the semi-circular connector 1 is controlled by the mechanical arm 5 to further adjust the irradiation angle of the accelerator assembly 3 to the human body or the quality control detection phantom;

[0012] Further, the accelerator assembly 3 includes an accelerator control system and an accelerator 3-1;

[0013] When in use, the dose tracking detection assembly 2 is adjusted to be perpendicular to the radiation source of the accelerator through the folding and lifting mechanism 4; the accelerator control system obtains the lifting and lowering adjustment data and transmits it to the folding and lifting mechanism 4 according to the change of the distance SAD from the radiation source of the accelerator to the central axis of the human body to be tested or the quality control detection phantom;

[0014] Furthermore, the folding lifting mechanism 4 is used to receive the lifting adjustment data output by the accelerator control system, and automatically adjust the position according to the lifting adjustment data, so that the dose tracking detection component tracks the accelerator in real time;

[0015] Optionally, the folding lifting mechanism 4 includes a lifting mechanism 1 4-1, a lifting mechanism 2 4-2, a first rotating member 4-3 and a second rotating member 4-4;

[0016] The first rotating member 4-3 is respectively connected to the lifting mechanism 1 4-1 and the semi-annular connecting member 1;

[0017] The second rotating member 4-4 is respectively connected to the lifting mechanism 1 4-1 and the lifting mechanism 2 4-2;

[0018] The lifting mechanism 2 4 - 2 is also connected to the dose tracking system 2;

[0019] The lifting mechanism 1 4-1 includes a sleeve 1 4-101 and a sleeve 2 4-102, and the sleeve 1 is sleeved with the sleeve 2;

[0020] The lifting mechanism 2 4-2 includes a sleeve 3 4-201 and a sleeve 4-202, and the sleeve 3 4-201 and the sleeve 4 4-202 are sleeved;

[0021] In one embodiment of the present invention, when non-treatment or non-quality control testing is performed, sleeve two 4-102 in lifting mechanism one of the folding lifting mechanism 4 is retracted into sleeve one, sleeve four 4-202 in lifting mechanism two is retracted into sleeve three 4-201, the second rotating member 4-4 is rotated to fold lifting mechanism one and lifting mechanism two, and then the first rotating member 4-3 is rotated to rotate the folded lifting mechanism one, lifting mechanism two and dose tracking detection assembly 2 to the side close to the robotic arm 5, which is beneficial to saving operating space.

[0022] When performing treatment or quality control testing, control the first rotating member 4-3 to rotate, rotate the lifting mechanism 1, the lifting mechanism 2 and the dose tracking detection assembly 2 to the side away from the robotic arm 5, and then rotate the second rotating member 4-4, and place the dose tracking detection assembly 3 to a suitable position by adjusting the positions of the lifting mechanism 1 and the lifting mechanism 2.

[0023] Furthermore, the ratio of the lifting range of the lifting mechanism 1 and the lifting mechanism 2 to the radius of the semi-annular connecting member is: 9-17:12;

[0024] Exemplarily, the lifting range SID of the lifting mechanism is 90-170 cm;

[0025] The radius of the semi-annular connecting piece is 120 cm.

[0026] Exemplarily, the size of the housing 2 - 1 is 15 cm×15 cm×10 cm;

[0027] The material of the shell 2-1 is amorphous selenium;

[0028] Furthermore, the dose tracking component 2 includes a housing 2-1 and a dose tracking detector 2-2, and the dose tracking detector 2-2 is arranged in the housing 2-1; the dose tracking detector component 2 is used to track the accelerator in real time and obtain the dose information of the irradiated human body or the quality control detection model;

[0029] The dose tracking detector 2-2 is used to convert the X-rays emitted by the accelerator into electric charges representing an image to form a dose distribution image, which is compared with the planned dose in the radiotherapy planning system TPS to obtain an error;

[0030] Furthermore, the dose tracking detector 2 - 2 includes image information (in DICOM format) input, image information output and dose analysis functions.

[0031] The dose tracking detector 2-2 includes a photodiode array 2-201, a driver 2-202 and a reading module 2-203;

[0032] The photodiode array 2-201, the driver 2-202 and the reading module 2-203 are connected in sequence and arranged in the housing 2-1;

[0033] The photodiode array 2-201 is used to receive X-rays and convert them into electrical signals; the photodiode array includes multiple pixels, each pixel includes a photodiode and a thin film transistor, the photodiode acts as a capacitor, the absorbed light is captured and converted into electric charges, and the electric charges are converted into digital signals, thereby obtaining information of the specific pixel.

[0034] The driver 2-202 is used to activate the analog signal; the reading module 2-203 is used to read the electronic device, convert the charge into an analog signal, and then convert the analog signal into a digital signal and transmit it to the image management system; it can be understood that the image management system executes and manages the image, and processes and stores the image calibration data;

[0035] The image management system and the dose tracking detection software are independently installed on a set of computers. The image management system inputs or outputs the image information into a DICOM format file to the dose tracking system software or other subsystems of the accelerator.

[0036] The present invention also includes a safety interlock device 6; the shell 2-1 is connected to the safety interlock device 6; during use, when the safety interlock device connected to the shell 2-1 collides with a human body or an object and is subjected to an impact force of more than 50N, the safety interlock is triggered, the folding and lifting mechanism, the dose tracking detection component movement, and the accelerator irradiation are stopped.

[0037] Optionally, the safety interlocking device 6 includes a membrane switch 1 6-1, a membrane switch 2 6-2 and a lead wire 6-3;

[0038] The membrane switch 1 6 - 1 and the membrane switch 2 6 - 2 both include polyester film, conductive silver paste and conductive carbon paste; the conductive silver paste and conductive carbon paste are respectively disposed on the polyester film; the thickness of the polyester film (PET) is about 0.05 mm.

[0039] The membrane switch 1 6-1 and the membrane switch 2 6-2 are connected to the upper and lower surfaces of the housing 2-1 respectively; the membrane switch 1 6-1 is connected to the membrane switch 2 6-2 via a lead wire 6-3; the lead wire 6-3 is also connected to the accelerator assembly 3;

[0040] When membrane switch 1 6-1 contacts a patient or other equipment, it indicates that the dose tracking detection component 2 contacts a patient or other equipment, and an interlocking electrical signal is generated between membrane switch 1 6-1 and membrane switch 2 6-2. The interlocking electrical signal is transmitted to the accelerator control system through lead wire 6-3 to control the accelerator 3-1 to stop working.

[0041] In one embodiment of the present invention, in a non-treatment state, the dose tracking detection assembly 2 is arranged at an initial position along the horizontal direction, and the radiation source of the accelerator assembly 3 is perpendicular to the dose tracking detection assembly 2;

[0042] In the treatment state, according to the actual situation of the patient's body or the quality control test phantom to be irradiated, the body or quality control test phantom and the dose tracking detection assembly are lifted and lowered to the corresponding position in the vertical direction, that is, the distance from the radiation source to the dose tracking system is 100-140cm.

[0043] Another object of the present invention is to provide a method for using a stereotactic radiotherapy device for achieving dose tracking, comprising:

[0044] Step S1, calibrating the calibrated stereotactic radiotherapy device for achieving dose tracking to obtain a calibrated stereotactic radiotherapy device for achieving dose tracking;

[0045] Step S2, establishing a treatment plan for the patient in a treatment planning system, wherein the treatment plan includes a treatment target area and a planned treatment dose;

[0046] The accelerator assembly 3 irradiates the patient according to the treatment plan;

[0047] Step S3, obtaining the actual irradiation dose through the dose tracking detection component 2;

[0048] Acquire the remaining unirradiated planned dose in the treatment plan based on the actual irradiation dose;

[0049] Step S4, in the treatment planning system, the actual irradiation dose and the remaining unirradiated planned dose are accumulated and superimposed to obtain an overall planned distribution, and based on the overall planned distribution, the dose changes of the treatment target area and the organ at risk are analyzed to obtain an analysis result;

[0050] Step S5: Evaluate whether to continue the patient treatment plan based on the analysis result.

[0051] Optionally, in step five, based on the analysis result, it is evaluated whether to continue the patient treatment plan. If so, the patient treatment plan is continued; if not, the patient treatment plan is modified.

[0052] The present invention evaluates the actual dose changes of the treatment target area and the organs at risk, which can better protect the organs at risk and improve the coverage of the target area dose, and provide a reference for the next step of dose-guided radiotherapy and adaptive radiotherapy.

[0053] Preferably, the specific steps of obtaining the calibrated stereotactic radiotherapy device for achieving dose tracking in step S1 include:

[0054] Step S11, placing the quality control detection phantom on the treatment bed, aligning the center positions of the quality control detection phantom, the radiation source of the accelerator 3-1 and the dose tracking detection component 2, and adjusting the initial position of the quality control detection phantom;

[0055] Step S12, selecting multiple groups of collimators with different emissivity of the accelerator 3-1 and irradiating the quality control detection phantom at the initial position with different doses MU respectively to obtain the tracking dose of the quality control detection phantom;

[0056] Using the traced dose of the quality control detection phantom as the calibration value of the dose tracing detection component 2 and establishing a dose tracing linear relationship;

[0057] Step S13, selecting a detector; selecting a plurality of groups of collimators with different emissivity to irradiate the detector, and obtaining the tracking dose of the detector through the dose tracking detection component 2;

[0058] Performing a first verification of the calibration value of the dose tracking system using the tracking dose of the detector based on the dose tracking linear relationship;

[0059] Step S14, performing a second verification on the calibration value of the dose tracking system based on the tracking dose of the quality control detection phantom in step S12 and the dose tracking linear relationship, to obtain a dose tracking detection component 2 after the second verification;

[0060] Step S15: creating a treatment plan for the patient;

[0061] The accelerator 3-1 irradiates the patient according to the treatment plan, and obtains the actual irradiation dose based on the dose tracking detection component 2 after secondary verification;

[0062] Step S16, analyzing the actual irradiation dose and the planned treatment dose described in step S15 according to the dose-dose tracking linear relationship and the analysis conditions to obtain analysis result 1;

[0063] If the analysis result satisfies the analysis condition, i.e. the dose tracking detection component is verified to be effective, the next step is entered; if not, steps S11-S15 are repeated;

[0064] Step S17, select a detector, repeat steps S15-S16, and obtain analysis result 2;

[0065] The analysis result 1 and the analysis result 2 are compared to determine whether the difference in the results is within an acceptable range; if the result is acceptable, a calibrated stereotactic radiotherapy device for achieving dose tracking is obtained.

[0066] Furthermore, the specific steps of obtaining the calibrated stereotactic radiotherapy device for achieving dose tracking in step S1 include:

[0067] Step S11, select a quality control detection phantom; place the quality control detection phantom at the isocenter position of the treatment bed, align the center positions of the quality control detection phantom, the radiation source of the accelerator 3-1 and the dose tracking detection component 2 according to the external laser light, and adjust the initial position of the quality control detection phantom;

[0068] Step S12, selecting a plurality of collimators of different emissivity from the accelerator 3-1;

[0069] Each group of collimators 3 - 1 uses different doses MU to irradiate the quality control detection phantom at the initial position, and obtains the tracking dose of the quality control detection phantom based on the dose tracking detection component 2;

[0070] Using the traced dose of the quality control detection phantom as a calibration value of the dose trace detection component 2;

[0071] Establishing a dose tracking linear relationship based on the calibration value of the dose tracking detection component 2;

[0072] Step S13, selecting a detector; placing the detector at the isocenter position of the treatment bed, selecting multiple groups of collimators with different radioactivity in the accelerator, each group of collimators respectively selects a different dose MU to irradiate the detector according to the clinical dose rate, and obtaining the tracking dose of the detector through the dose tracking detection component 2;

[0073] Performing a first verification of the calibration value of the dose tracking system based on the dose tracking linear relationship of the detector's tracking dose; obtaining a dose tracking detection component 2 after a first verification;

[0074] Preferably, the detector is a semiconductor matrix detector SRS MapCHECK;

[0075] Preferably, the clinical dose rate is 1000MU / min;

[0076] The different doses include 10MU-2000MU, in units of 50MU;

[0077] Step S14, randomly extracting multiple groups of data of the tracing dose of the quality control detection phantom in step S12, performing a second verification on the calibration value of the dose tracing system based on the dose tracing linear relationship for each group of data, and obtaining a dose tracing detection component 2 after the second verification;

[0078] Step S15, in the treatment planning system, creating a treatment plan for the patient; the treatment plan includes a static target area planned treatment dose, a static target area planned treatment dose, a dynamic target area planned treatment dose, and a dynamic target area planned treatment dose;

[0079] The accelerator 3-1 irradiates the patient according to the treatment plan, and obtains the actual irradiation dose based on the dose tracking detection component 2 after secondary verification; the actual irradiation dose includes the actual irradiation dose of the static target area and the actual irradiation dose of the dynamic target area;

[0080] Step S16, analyzing the actual irradiation dose of the static target area, the actual irradiation dose of the dynamic target area, and the planned treatment dose of the static target area and the planned treatment dose of the dynamic target area described in step S15 according to the dose-dose tracking linear relationship and the analysis conditions to obtain analysis result 1;

[0081] If the analysis result satisfies the analysis condition, i.e. the dose tracking detection component is verified to be effective, the next step is entered; if not, steps S11-S15 are repeated;

[0082] Optionally, the analysis condition in step S16 is a static target area plan, the threshold is 50%, the standard of 2% / 2mm is adopted, and the γ pass rate is above 90%; for a dynamic target area tracking plan, the threshold is 50%, the standard of 3% / 3mm is adopted, and the γ pass rate is above 90%.

[0083] Step S17, select a detector, repeat steps S15-S16, and obtain analysis result 2;

[0084] Compare the analysis result 1 with the analysis result 2 to see if the difference is within an acceptable range of 5%. If the result is acceptable, the accelerator assembly 3 meets the clinical requirements and a calibrated stereotactic radiotherapy device for achieving dose tracking is obtained. Otherwise, check the clinical performance of the accelerator assembly 3.

[0085] In one embodiment of the present invention, a stereotactic radiotherapy device that implements dose tracking is used to perform quality control testing, including: evaluating position accuracy, isocentric accuracy, patient quality control plan DQA testing, and providing overall accuracy information of complex target area doses in non-isocentric treatment plans.

[0086] Exemplarily, the specific steps of performing mechanical part quality control using a stereotactic radiotherapy device that implements dose tracking include:

[0087] In the patient treatment QA mode, set up the Picket Fence test at different gantry angles;

[0088] The dose line set in the dose tracking detector 2-2 is evaluated to determine whether the position is accurate.

[0089] Exemplarily, the isocenter accuracy test is performed using a stereotactic radiotherapy device that implements dose tracking, and the specific steps include:

[0090] In the patient treatment QA mode, images of the dose tracking system were taken sequentially at gantry angles of 0°, 90°, 180°, 270° and table rotation angles of 45°, 90°, and 315°.

[0091] Analyze the difference between the center and isocenter of the dose tracking system, and the deviation should be less than 1mm.

[0092] Exemplarily, using a stereotactic radiotherapy device that implements dose tracking to provide accuracy information of target area dose in a non-isocentric treatment plan, the specific steps include:

[0093] a) calibrating the dose tracking detection component 2 to obtain a reference value;

[0094] b) Import the CT image data of the phantom into the treatment planning system, and establish the original treatment plan QA template and the dose distribution of the original treatment plan;

[0095] c) In the treatment planning system, formulate patient treatment plans;

[0096] d) Import the patient treatment plan into the original treatment plan QA template and establish the patient treatment plan QA;

[0097] e) executing the patient treatment plan plan QA, and obtaining the actual dose distribution of the patient treatment plan plan QA based on the dose tracking detection component 2;

[0098] f) Analyze the difference between the actual dose distribution of the patient's treatment plan QA and the dose distribution of the original treatment plan to determine whether the difference meets the clinical requirements.

[0099] It is understandable that the clinical requirements include: a threshold of 50%, a standard of 2% / 2mm, and a pass rate requirement of more than 90%. For synchronous respiratory tracking plans, the threshold is 50%, a standard of 3% / 3mm is used, and the pass rate requirement is also more than 90%.

[0100] Compared with the prior art, the present invention has at least the following beneficial effects:

[0101] (1) The semi-ring structure of the present invention carries a 6MV medical linear accelerator and a dose tracking detection component to achieve dose distribution reconstruction during non-public surface treatment and obtain dose changes in the target area and organs at risk, which can better protect organs at risk and improve the coverage of target area dose, providing a reference for the next step of dose-guided radiotherapy and adaptive radiotherapy;

[0102] (2) The present invention obtains dose information during radiotherapy based on the dose detection component, providing real data for analyzing the dose of radiotherapy;

[0103] (3) The dose detection assembly in the present invention is connected by a folding and telescopic mechanism, through which the dose detection assembly can be quickly adjusted to the radiation area, the position and distance of the dose detection assembly, the treatment bed and the accelerator can be adjusted, the irradiation dose can be obtained in real time, the flexible placement of the treatment bed is improved, and the working time of the staff is saved;

[0104] (4) The dose detection assembly and the folding and telescopic mechanism in the present invention can be retracted to the side close to the mechanical arm, which is conducive to saving operating space;

[0105] (5) The present invention can detect multiple quality control items through the dose detection component, improve quality control efficiency, and optimize quality control tools;

[0106] (6) The dosage information obtained by the present invention is recorded digitally without the need for film development, making the information easier to maintain and facilitating the transition to paperless work. BRIEF DESCRIPTION OF THE DRAWINGS

[0107] The drawings are only for the purpose of illustrating particular embodiments and are not to be construed as limiting the invention.

[0108] Figure 1 A schematic diagram of the structure of a stereotactic radiotherapy device for achieving dose tracking in an embodiment of the present invention during treatment of a patient;

[0109] Figure 2 A schematic diagram of the structure of a stereotactic radiotherapy device for achieving dose tracking in a non-treatment process according to an embodiment of the present invention;

[0110] Figure 3 (a)-(b) are schematic diagrams of the retracting and extending structures of the lifting mechanism in the folding lifting mechanism in an embodiment of the present invention;

[0111] Figure 4 A schematic diagram of the structure of a dose tracking detector in an embodiment of the present invention;

[0112] Figure 5 A schematic diagram of a safety interlocking device in an embodiment of the present invention;

[0113] Figure 6 It is a schematic diagram of a stereotactic radiotherapy device implementing dose tracking in an embodiment of the present invention during a patient treatment process.

[0114] Reference numerals:

[0115] Semi-circular connector 1, dose tracking detection component 2, accelerator component 3, folding lifting mechanism 4, mechanical arm 5, safety interlock device 6, shell 2-1, dose tracking detection component 2-2, photodiode array 2-201, driver 2-202, reading module 2-203, accelerator 3-1, lifting mechanism one 4-1, lifting mechanism two 4-2, first rotating member 4-3, second rotating member 4-4, sleeve one 4-101, sleeve two 4-102, sleeve three 4-201, sleeve four 4-202, membrane switch one 6-1, membrane switch two 6-2, lead wire 6-3. DETAILED DESCRIPTION

[0116] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other. In addition, the present invention can also be implemented in other ways different from those described herein, and therefore, the protection scope of the present invention is not limited by the specific embodiments disclosed below.

[0117] A specific embodiment of the present invention, as Figure 1-6, discloses a stereotactic radiotherapy device for realizing dose tracking and a method for using the same. In order to illustrate the effectiveness of the method proposed in the present invention, the above technical solution of the present invention is described in detail through a specific embodiment below. The specific implementation steps are as follows:

[0118] An object of the present invention is to provide a stereotactic radiotherapy device for achieving dose tracking, comprising:

[0119] A semi-annular connector 1, a dose tracking detection assembly 2, an accelerator assembly 3 and a folding and lifting mechanism 4;

[0120] The semi-annular connector 1 is respectively connected to the accelerator assembly 3 and the folding and lifting mechanism 4; the folding and lifting mechanism 4 is also connected to the dose tracking detection assembly 2;

[0121] In one embodiment of the present invention, the dose tracking detection assembly 2 is arranged on the upper side of the folding and lifting mechanism 4 in the horizontal direction;

[0122] Optionally, the middle position of the semi-annular connector 1 is connected to a robotic arm 5, and the robotic arm 5 controls the semi-annular bracket to rotate 360 ​​degrees according to treatment requirements, so that the dose tracking system can follow the beam in real time to perform global irradiation;

[0123] The semi-circular connector 1 is respectively connected to the accelerator assembly 3 and the folding and lifting mechanism 4. During the treatment process, the movement of the semi-circular connector 1 is controlled by the mechanical arm 5 to further adjust the irradiation angle of the accelerator assembly 3 to the human body or the quality control detection phantom;

[0124] Further, the accelerator assembly 3 includes an accelerator control system and an accelerator 3-1;

[0125] When in use, the dose tracking detection assembly 2 is adjusted to be perpendicular to the radiation source of the accelerator through the folding and lifting mechanism 4; the accelerator control system obtains the lifting and lowering adjustment data and transmits it to the folding and lifting mechanism 4 according to the change of the distance SAD from the radiation source of the accelerator to the central axis of the human body to be tested or the quality control detection phantom;

[0126] Furthermore, the folding lifting mechanism 4 is used to receive the lifting adjustment data output by the accelerator control system, and automatically adjust the position according to the lifting adjustment data, so that the dose tracking detection component tracks the accelerator in real time;

[0127] Optionally, the folding lifting mechanism 4 includes a lifting mechanism 1 4-1, a lifting mechanism 2 4-2, a first rotating member 4-3 and a second rotating member 4-4;

[0128] The first rotating member 4-3 is respectively connected to the lifting mechanism 1 4-1 and the semi-annular connecting member 1;

[0129] The second rotating member 4-4 is respectively connected to the lifting mechanism 1 4-1 and the lifting mechanism 2 4-2;

[0130] The lifting mechanism 2 4 - 2 is also connected to the dose tracking system 2;

[0131] The lifting mechanism 1 4-1 includes a sleeve 1 4-101 and a sleeve 2 4-102, and the sleeve 1 is sleeved with the sleeve 2;

[0132] The lifting mechanism 2 4-2 includes a sleeve 3 4-201 and a sleeve 4-202, and the sleeve 3 4-201 and the sleeve 4 4-202 are sleeved;

[0133] In one embodiment of the present invention, when non-treatment or non-quality control testing is performed, sleeve two 4-102 in lifting mechanism one of the folding lifting mechanism 4 is retracted into sleeve one, sleeve four 4-202 in lifting mechanism two is retracted into sleeve three 4-201, the second rotating member 4-4 is rotated to fold lifting mechanism one and lifting mechanism two, and then the first rotating member 4-3 is rotated to rotate the folded lifting mechanism one, lifting mechanism two and dose tracking detection assembly 2 to the side close to the robotic arm 5, which is beneficial to saving operating space.

[0134] When performing treatment or quality control testing, control the first rotating member 4-3 to rotate, rotate the lifting mechanism 1, the lifting mechanism 2 and the dose tracking detection assembly 2 to the side away from the robotic arm 5, and then rotate the second rotating member 4-4, and place the dose tracking detection assembly 3 to a suitable position by adjusting the positions of the lifting mechanism 1 and the lifting mechanism 2.

[0135] Furthermore, the ratio of the lifting range of the lifting mechanism 1 and the lifting mechanism 2 to the radius of the semi-annular connecting member is: 9-17:12;

[0136] Exemplarily, the lifting range SID of the lifting mechanism is 90-170 cm;

[0137] The radius of the semi-annular connecting piece is 120 cm.

[0138] Exemplarily, the size of the housing 2 - 1 is 15 cm×15 cm×10 cm;

[0139] The material of the shell 2-1 is amorphous selenium;

[0140] Furthermore, the dose tracking component 2 includes a housing 2-1 and a dose tracking detector 2-2, and the dose tracking detector 2-2 is arranged in the housing 2-1; the dose tracking detector component 2 is used to track the accelerator in real time and obtain the dose information of the irradiated human body or the quality control detection model;

[0141] The dose tracking detector 2-2 is used to convert the X-rays emitted by the accelerator into electric charges representing an image to form a dose distribution image, which is compared with the planned dose in the radiotherapy planning system TPS to obtain an error;

[0142] Furthermore, the dose tracking detector 2 - 2 includes image information (in DICOM format) input, image information output and dose analysis functions.

[0143] The dose tracking detector 2-2 includes a photodiode array 2-201, a driver 2-202 and a reading module 2-203;

[0144] The photodiode array 2-201, the driver 2-202 and the reading module 2-203 are connected in sequence and arranged in the housing 2-1;

[0145] The photodiode array 2-201 is used to receive X-rays and convert them into electrical signals; the photodiode array includes multiple pixels, each pixel includes a photodiode and a thin film transistor, the photodiode acts as a capacitor, the absorbed light is captured and converted into electric charges, and the electric charges are converted into digital signals, thereby obtaining information of the specific pixel.

[0146] The driver 2-202 is used to activate the analog signal; the reading module 2-203 is used to read the electronic device, convert the charge into an analog signal, and then convert the analog signal into a digital signal and transmit it to the image management system; it can be understood that the image management system executes and manages the image, and processes and stores the image calibration data;

[0147] The image management system and the dose tracking detection software are independently installed on a set of computers. The image management system inputs or outputs the image information into a DICOM format file to the dose tracking system software or other subsystems of the accelerator.

[0148] The present invention also includes a safety interlock device 6; the shell 2-1 is connected to the safety interlock device 6; during use, when the safety interlock device connected to the shell 2-1 collides with a human body or an object and is subjected to an impact force of more than 50N, the safety interlock is triggered, the folding and lifting mechanism, the dose tracking detection component movement, and the accelerator irradiation are stopped.

[0149] Optionally, the safety interlocking device 6 includes a membrane switch 1 6-1, a membrane switch 2 6-2 and a lead wire 6-3;

[0150] The membrane switch 1 6 - 1 and the membrane switch 2 6 - 2 both include polyester film, conductive silver paste and conductive carbon paste; the conductive silver paste and conductive carbon paste are respectively disposed on the polyester film; the thickness of the polyester film (PET) is about 0.05 mm.

[0151] The membrane switch 1 6-1 and the membrane switch 2 6-2 are connected to the upper and lower surfaces of the housing 2-1 respectively; the membrane switch 1 6-1 is connected to the membrane switch 2 6-2 via a lead wire 6-3; the lead wire 6-3 is also connected to the accelerator assembly 3;

[0152] When membrane switch 1 6-1 contacts a patient or other equipment, it indicates that the dose tracking detection component 2 contacts a patient or other equipment, and an interlocking electrical signal is generated between membrane switch 1 6-1 and membrane switch 2 6-2. The interlocking electrical signal is transmitted to the accelerator control system through lead wire 6-3 to control the accelerator 3-1 to stop working.

[0153] In one embodiment of the present invention, in a non-treatment state, the dose tracking detection assembly 2 is arranged at an initial position along the horizontal direction, and the radiation source of the accelerator assembly 3 is perpendicular to the dose tracking detection assembly 2;

[0154] In the treatment state, according to the actual situation of the patient's body or the quality control test phantom to be irradiated, the body or quality control test phantom and the dose tracking detection assembly are lifted and lowered to the corresponding position in the vertical direction, that is, the distance from the radiation source to the dose tracking system is 100-140cm.

[0155] Another object of the present invention is to provide a method for using a stereotactic radiotherapy device for achieving dose tracking, comprising:

[0156] Step S1, calibrating the calibrated stereotactic radiotherapy device for achieving dose tracking to obtain a calibrated stereotactic radiotherapy device for achieving dose tracking;

[0157] Step S2, establishing a treatment plan for the patient in a treatment planning system, wherein the treatment plan includes a treatment target area and a planned treatment dose;

[0158] The accelerator assembly 3 irradiates the patient according to the treatment plan;

[0159] Step S3, obtaining the actual irradiation dose through the dose tracking detection component 2;

[0160] Acquire the remaining unirradiated planned dose in the treatment plan based on the actual irradiation dose;

[0161] Step S4, in the treatment planning system, the actual irradiation dose and the remaining unirradiated planned dose are accumulated and superimposed to obtain an overall planned distribution, and based on the overall planned distribution, the dose changes of the treatment target area and the organ at risk are analyzed to obtain an analysis result;

[0162] Step S5: Evaluate whether to continue the patient treatment plan based on the analysis result.

[0163] Optionally, in step five, based on the analysis result, it is evaluated whether to continue the patient treatment plan. If so, the patient treatment plan is continued; if not, the patient treatment plan is modified.

[0164] The present invention evaluates the actual dose changes of the treatment target area and the organs at risk, which can better protect the organs at risk and improve the coverage of the target area dose, and provide a reference for the next step of dose-guided radiotherapy and adaptive radiotherapy.

[0165] Preferably, the specific steps of obtaining the calibrated stereotactic radiotherapy device for achieving dose tracking in step S1 include:

[0166] Step S11, placing the quality control detection phantom on the treatment bed, aligning the center positions of the quality control detection phantom, the radiation source of the accelerator 3-1 and the dose tracking detection component 2, and adjusting the initial position of the quality control detection phantom;

[0167] Step S12, selecting multiple groups of collimators with different emissivity of the accelerator 3-1 and irradiating the quality control detection phantom at the initial position with different doses MU respectively to obtain the tracking dose of the quality control detection phantom;

[0168] Using the traced dose of the quality control detection phantom as the calibration value of the dose tracing detection component 2 and establishing a dose tracing linear relationship;

[0169] Step S13, selecting a detector; selecting a plurality of groups of collimators with different emissivity to irradiate the detector, and obtaining the tracking dose of the detector through the dose tracking detection component 2;

[0170] Performing a first verification of the calibration value of the dose tracking system using the tracking dose of the detector based on the dose tracking linear relationship;

[0171] Step S14, performing a second verification on the calibration value of the dose tracking system based on the tracking dose of the quality control detection phantom in step S12 and the dose tracking linear relationship, to obtain a dose tracking detection component 2 after the second verification;

[0172] Step S15: creating a treatment plan for the patient;

[0173] The accelerator 3-1 irradiates the patient according to the treatment plan, and obtains the actual irradiation dose based on the dose tracking detection component 2 after secondary verification;

[0174] Step S16, analyzing the actual irradiation dose and the planned treatment dose described in step S15 according to the dose-dose tracking linear relationship and the analysis conditions to obtain analysis result 1;

[0175] If the analysis result satisfies the analysis condition, i.e. the dose tracking detection component is verified to be effective, the next step is entered; if not, steps S11-S15 are repeated;

[0176] Step S17, select a detector, repeat steps S15-S16, and obtain analysis result 2;

[0177] The analysis result 1 and the analysis result 2 are compared to determine whether the difference in the results is within an acceptable range; if the result is acceptable, a calibrated stereotactic radiotherapy device for achieving dose tracking is obtained.

[0178] Furthermore, the specific steps of obtaining the calibrated stereotactic radiotherapy device for achieving dose tracking in step S1 include:

[0179] Step S11, select a quality control detection phantom; place the quality control detection phantom at the isocenter position of the treatment bed, align the center positions of the quality control detection phantom, the radiation source of the accelerator 3-1 and the dose tracking detection component 2 according to the external laser light, and adjust the initial position of the quality control detection phantom;

[0180] Step S12, selecting a plurality of collimators of different emissivity from the accelerator 3-1;

[0181] Each group of collimators 3 - 1 uses different doses MU to irradiate the quality control detection phantom at the initial position, and obtains the tracking dose of the quality control detection phantom based on the dose tracking detection component 2;

[0182] Using the traced dose of the quality control detection phantom as a calibration value of the dose trace detection component 2;

[0183] Establishing a dose tracking linear relationship based on the calibration value of the dose tracking detection component 2;

[0184] Step S13, selecting a detector; placing the detector at the isocenter position of the treatment bed, selecting multiple groups of collimators with different radioactivity in the accelerator, each group of collimators respectively selects a different dose MU to irradiate the detector according to the clinical dose rate, and obtaining the tracking dose of the detector through the dose tracking detection component 2;

[0185] Performing a first verification of the calibration value of the dose tracking system based on the dose tracking linear relationship of the detector's tracking dose; obtaining a dose tracking detection component 2 after a first verification;

[0186] Preferably, the detector is a semiconductor matrix detector SRS MapCHECK;

[0187] Preferably, the clinical dose rate is 1000MU / min;

[0188] The different doses include 10MU-2000MU, in units of 50MU;

[0189] Step S14, randomly extracting multiple groups of data of the tracing dose of the quality control detection phantom in step S12, performing a second verification on the calibration value of the dose tracing system based on the dose tracing linear relationship for each group of data, and obtaining a dose tracing detection component 2 after the second verification;

[0190] Step S15, in the treatment planning system, creating a treatment plan for the patient; the treatment plan includes a static target area planned treatment dose, a static target area planned treatment dose, a dynamic target area planned treatment dose, and a dynamic target area planned treatment dose;

[0191] The accelerator 3-1 irradiates the patient according to the treatment plan, and obtains the actual irradiation dose based on the dose tracking detection component 2 after secondary verification; the actual irradiation dose includes the actual irradiation dose of the static target area and the actual irradiation dose of the dynamic target area;

[0192] Step S16, analyzing the actual irradiation dose of the static target area, the actual irradiation dose of the dynamic target area, and the planned treatment dose of the static target area and the planned treatment dose of the dynamic target area described in step S15 according to the dose-dose tracking linear relationship and the analysis conditions to obtain analysis result 1;

[0193] If the analysis result satisfies the analysis condition, i.e. the dose tracking detection component is verified to be effective, the next step is entered; if not, steps S11-S15 are repeated;

[0194] Optionally, the analysis condition in step S16 is a static target area plan, the threshold is 50%, the standard of 2% / 2mm is adopted, and the γ pass rate is above 90%; for a dynamic target area tracking plan, the threshold is 50%, the standard of 3% / 3mm is adopted, and the γ pass rate is above 90%.

[0195] Step S17, select a detector, repeat steps S15-S16, and obtain analysis result 2;

[0196] Compare the analysis result 1 with the analysis result 2 to see if the difference is within an acceptable range of 5%. If the result is acceptable, the accelerator assembly 3 meets the clinical requirements and a calibrated stereotactic radiotherapy device for achieving dose tracking is obtained. Otherwise, check the clinical performance of the accelerator assembly 3.

[0197] In one embodiment of the present invention, a stereotactic radiotherapy device that implements dose tracking is used to perform quality control testing, including: evaluating position accuracy, isocentric accuracy, patient quality control plan DQA testing, and providing overall accuracy information of complex target area doses in non-isocentric treatment plans.

[0198] Exemplarily, the specific steps of performing mechanical part quality control using a stereotactic radiotherapy device that implements dose tracking include:

[0199] In the patient treatment QA mode, set up the Picket Fence test at different gantry angles;

[0200] The dose line set in the dose tracking detector 2-2 is evaluated to determine whether the position is accurate.

[0201] Exemplarily, the isocenter accuracy test is performed using a stereotactic radiotherapy device that implements dose tracking, and the specific steps include:

[0202] In the patient treatment QA mode, images of the dose tracking system were taken in sequence at gantry angles of 0°, 90°, 180°, 270° and table rotation angles of 45°, 90°, and 315°.

[0203] Analyze the difference between the center and isocenter of the dose tracking system, and the deviation should be less than 1mm.

[0204] Exemplarily, using a stereotactic radiotherapy device that implements dose tracking to provide accuracy information of target area dose in a non-isocentric treatment plan, the specific steps include:

[0205] a) calibrating the dose tracking detection component 2 to obtain a reference value;

[0206] b) In the treatment planning system, the CT image data of the phantom is imported to establish the original treatment plan QA template and the dose distribution of the original treatment plan;

[0207] c) In the treatment planning system, formulate the patient treatment plan;

[0208] d) Import the patient treatment plan into the original treatment plan QA template and establish the patient treatment plan QA;

[0209] e) executing the patient treatment plan plan QA, and obtaining the actual dose distribution of the patient treatment plan plan QA based on the dose tracking detection component 2;

[0210] f) Analyze the difference between the actual dose distribution of the patient's treatment plan QA and the dose distribution of the original treatment plan to determine whether the difference meets the clinical requirements.

[0211] It is understandable that the clinical requirements include: a threshold of 50%, a standard of 2% / 2mm, and a pass rate requirement of more than 90%. For synchronous respiratory tracking plans, the threshold is 50%, a standard of 3% / 3mm is used, and the pass rate requirement is also more than 90%.

[0212] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by any technician familiar with the technical field within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention.

Claims

1. A stereotactic radiotherapy device for achieving dose tracking, characterized in that: include: A semi-annular connecting member (1), a dose tracking detection component (2), an accelerator component (3), and a folding and lifting mechanism (4); The semi-annular connecting member (1) is respectively connected to the accelerator assembly (3) and the folding and lifting mechanism (4); the folding and lifting mechanism (4) is also connected to the dose tracking detection assembly (2); The dose tracking detection component (2) is arranged on the upper side of the folding and lifting mechanism (4) in the horizontal direction; The dose tracking detection component (2) is used to track the accelerator in real time and obtain dose information of the irradiated human body or quality control test phantom; The folding lifting mechanism (4) is used to receive lifting adjustment data and automatically adjust the position according to the lifting adjustment data, so that the dose tracking detection component tracks the accelerator in real time.

2. The stereotactic radiotherapy device for achieving dose tracking according to claim 1, characterized in that: The dose tracking component (2) comprises a housing (2-1) and a dose tracking detector (2-2), wherein the dose tracking detector (2-2) is arranged in the housing (2-1); The accelerator assembly (3) comprises an accelerator (3-1); The dose tracking detection component (2) is adjusted to be perpendicular to the radiation source of the accelerator (3-1) through a folding and lifting mechanism (4).

3. The stereotactic radiotherapy device for achieving dose tracking according to claim 2, characterized in that: The dose tracking detector (2-2) comprises a photodiode array (2-201), a driver (2-202) and a reading module (2-203); The photodiode array (2-201), the driver (2-202) and the reading module (2-203) are connected in sequence and arranged in the housing (2-1).

4. The stereotactic radiotherapy device for achieving dose tracking according to claim 1, characterized in that: The folding lifting mechanism (4) comprises a lifting mechanism 1 (4-1), a lifting mechanism 2 (4-2), a first rotating member (4-3) and a second rotating member (4-4); The first rotating member (4-3) is respectively connected to the lifting mechanism 1 (4-1) and the semi-annular connecting member (1); The second rotating member (4-4) is respectively connected to the lifting mechanism 1 (4-1) and the lifting mechanism 2 (4-2); The second lifting mechanism (4-2) is also connected to the dosage tracking system (2).

5. The stereotactic radiotherapy device for achieving dose tracking according to claim 4, characterized in that: The lifting mechanism 1 (4-1) comprises a sleeve 1 (4-101) and a sleeve 2 (4-102), wherein the sleeve 1 is sleeve-connected with the sleeve 2; The lifting mechanism 2 (4-2) comprises a sleeve 3 (4-201) and a sleeve 4 (4-202), and the sleeve 3 (4-201) and the sleeve 4 (4-202) are sleeve-connected.

6. The stereotactic radiotherapy device for achieving dose tracking according to claim 2, characterized in that: It also includes a safety interlocking device (6); the shell (2-1) is connected to the safety interlocking device (6); during use, when the safety interlocking device connected to the shell (2-1) collides with a human body or an object, the safety interlock is triggered, the movement of the folding and lifting mechanism and the dose tracking detection component (2) is stopped, and the irradiation of the accelerator is stopped.

7. The stereotactic radiotherapy device for achieving dose tracking according to claim 6, characterized in that: The safety interlocking device (6) comprises a membrane switch 1 (6-1), a membrane switch 2 (6-2) and a lead wire (6-3); The membrane switch 1 (6-1) and the membrane switch 2 (6-2) both include polyester film, conductive silver paste and conductive carbon paste; The membrane switch 1 (6-1) and the membrane switch 2 (6-2) are respectively connected to the upper and lower surfaces of the housing (2-1); the membrane switch 1 (6-1) is connected to the membrane switch 2 (6-2) via a lead wire (6-3); the lead wire (6-3) is also connected to the accelerator assembly (3).

8. A method for using a stereotactic radiotherapy device for achieving dose tracking according to any one of claims 1 to 7, characterized in that: include: Step S1, calibrating the calibrated stereotactic radiotherapy device for achieving dose tracking to obtain a calibrated stereotactic radiotherapy device for achieving dose tracking; Step S2, establishing a treatment plan for the patient in a treatment planning system, wherein the treatment plan includes a treatment target area and a planned treatment dose; The accelerator assembly (3) irradiates the patient according to the treatment plan; Step S3, obtaining the actual irradiation dose through the dose tracking detection component (2); Acquire the remaining unirradiated planned dose in the treatment plan based on the actual irradiation dose; Step S4: In the treatment planning system, the actual irradiation dose and the remaining unirradiated planned dose are accumulated and superimposed to obtain an overall planned distribution, and the dose changes of the treatment target area and the organs at risk are analyzed based on the overall planned distribution to obtain an analysis result.

9. The method for using the stereotactic radiotherapy device for achieving dose tracking according to claim 8, characterized in that: The specific steps of obtaining the calibrated stereotactic radiotherapy device for achieving dose tracking in step S1 include: Step S11, placing the quality control detection phantom on the treatment bed, aligning the center positions of the quality control detection phantom, the radiation source of the accelerator (3-1) and the dose tracking detection component (2), and adjusting the initial position of the quality control detection phantom; Step S12, selecting a plurality of collimators of different emissivity of the accelerator (3-1) and irradiating the quality control detection phantom at the initial position with different doses MU respectively, to obtain a tracking dose of the quality control detection phantom; Using the traced dose of the quality control detection phantom as a calibration value of the dose tracing detection component (2) and establishing a dose tracing linear relationship; Step S13, selecting a detector; selecting a plurality of groups of collimators with different emissivity to irradiate the detector, and obtaining a tracking dose of the detector through a dose tracking detection component (2); Performing a first verification of the calibration value of the dose tracking system using the tracking dose of the detector based on the dose tracking linear relationship; Step S14, performing a second verification on the calibration value of the dose tracking system based on the tracking dose of the quality control detection phantom in step S12 and the dose tracking linear relationship, to obtain a dose tracking detection component (2) after the second verification; Step S15: creating a treatment plan for the patient; The accelerator (3-1) irradiates the patient according to the treatment plan, and obtains the actual irradiation dose based on the dose tracking detection component (2) after secondary verification; Step S16, analyzing the actual irradiation dose and the planned treatment dose described in step S15 according to the dose-dose tracking linear relationship and the analysis conditions to obtain analysis result 1; If the analysis result satisfies the analysis condition, i.e. the dose tracking detection component is verified to be effective, the next step is entered; if not, steps S11-S15 are repeated; Step S17, select a detector, repeat steps S15-S16, and obtain analysis result 2; The analysis result 1 and the analysis result 2 are compared to determine whether the difference in the results is within an acceptable range; if the result is acceptable, a calibrated stereotactic radiotherapy device for achieving dose tracking is obtained.

10. The method for using the stereotactic radiotherapy device for achieving dose tracking according to claim 8, characterized in that: Also includes: Quality control testing using stereotactic radiotherapy equipment with dose tracking.

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