Acoustic transport capsule based on metamaterial
Through the acoustic transport capsule designed by superstructure materials, the equivalent parameter method is used to achieve precise control of the acoustic radiation force, which solves the problem of inflexible transport of acoustic radiation force in the existing technology, improves universality and cost-effectiveness, and promotes the Applications in the field of medicine.
Patent Information
- Application Number
- CN202411655738.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-19
- Publication Date
- 2025-02-11
AI Technical Summary
The prior art is difficult to realize a controllable acoustic radiation force transportation scheme that is not limited by the parameters of the transport structure, resulting in the need of specific new designs for acoustic radiation force transportation under different circumstances.
Acoustic transport capsules with layered spherical structures are designed using superstructure materials, and the capsule shell is laminated through the equivalent parameter method to achieve accurate regulation of the acoustic radiation force, so that different objects to be transported can obtain the same acoustic radiation force in the sound field. .
Accurate control of acoustic radiation force, improve the versatility of acoustic radiation force transportation schemes, and the same acoustic transport capsules can be used to transport different contents, reduce costs, and promote the acoustic radiation force in the medical field. application.
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Figure CN119406334A_ABST
Abstract
Description
Technical Field
[0001] The present invention belongs to the technical field of acoustic manipulation and measurement, and in particular relates to the design of an acoustic transport capsule using metamaterials. Background Art
[0002] Particle manipulation through the nonlinear effects of acoustic waves has broad application prospects in the fields of medicine, life sciences and industry. Acoustic radiation force is an effective way to achieve particle manipulation. This method can achieve non-contact manipulation, has good bioadaptability, low thermal effects and strong penetration. Based on the common wavelength scale of acoustic waves, acoustic radiation force is particularly suitable for manipulating cells, drugs and biological tissues. Since acoustic radiation force is sensitive to structural parameters and incident wave frequency when acting on particles and structures, the transportation of acoustic radiation force under different conditions often requires specific new designs. Therefore, realizing a controllable acoustic radiation force transmission scheme that is not restricted by the parameters of the transported structure has become an urgent issue to be solved. Summary of the invention
[0003] Purpose of the invention: In order to overcome the deficiencies in the prior art, the present invention provides an acoustic transport capsule based on metamaterials. The present invention adopts metamaterials to design the capsule structure so that different transported objects can obtain the same acoustic radiation force in the sound field, thereby achieving precise control of the acoustic radiation force and enabling different transported objects to obtain the same acoustic radiation force in the sound field.
[0004] Technical solution: To achieve the above-mentioned invention objectives, the present invention adopts the following technical solution: an acoustic transport capsule based on metamaterials, wherein the acoustic transport capsule is a layered spherical structure, including a capsule shell layer formed by stacking multiple material layers based on the equivalent parameter method, and an inner cavity located in the capsule shell layer for carrying the transported object, wherein the acoustic transport capsule can realize acoustic transport as a whole under the action of externally applied acoustic radiation force.
[0005] Preferably, the multilayer material layer comprises at least two or more different materials, and the material layers of different materials are stacked in sequence and then periodically repeated in the same order; and the thickness of each material layer is less than 1 / 10 of the wavelength of the sound wave.
[0006] Furthermore, the equivalent parameters of the multilayer materials of the capsule shell layer and the applied acoustic radiation force meet the following design requirements: , In the formula, F represents the acoustic radiation force on the acoustic capsule; ρ0 represents the density of the ambient medium; c0 represents the sound velocity of the ambient medium; represents the total velocity potential of the acoustic field where the acoustic capsule is located; The unit vector representing the propagation direction of the incident sound wave; s represents the outer surface of the acoustic capsule; z represents the propagation direction of the incident sound wave; t represents time; The total velocity potential of the acoustic field where the acoustic capsule is located , calculated by the following formula, , In the formula, represents the total velocity potential of the acoustic field where the acoustic capsule is located; is the incident sound wave velocity potential is the velocity potential of scattered sound waves; is the amplitude of the incident sound wave velocity potential; w is the circular frequency of the incident sound wave; i is the imaginary unit; is the nth-order Legendre function; is the nth-order spherical Bessel function of the first kind; is the zenith angle parameter of the spherical coordinates, k represents the wave number of the incident wave, and r is the outer diameter of the acoustic capsule; A n,s is the equivalent scattering coefficient of the acoustic capsule;
[0007] Equivalent scattering coefficient A of acoustic capsule n,s , then we get the following formula: , In the formula, A n,s is the equivalent scattering coefficient of the acoustic capsule, x, x1, x2 are intermediate quantities of variable substitution, c d is the equivalent radial sound velocity of the acoustic capsule, c s h is the equivalent transverse sound velocity of the acoustic capsule; n (x) represents the n-th order spherical Hankel function; represents the derivative of the variable; ρ0 represents the density of the ambient medium; ρ r represents the equivalent density of the acoustic capsule in the axial direction; ρ θ represents the equivalent density of the acoustic capsule in the lateral direction; κappa represents the equivalent bulk modulus of the acoustic capsule; , In the formula, ρ r represents the equivalent density of the acoustic capsule in the axial direction; ρ θ represents the equivalent density of the acoustic capsule in the lateral direction; ρ N represents the density of the Nth layer of material, η N represents the relative thickness of the Nth layer of material, κappa represents the equivalent bulk modulus of the acoustic capsule, and κappa_N represents the equivalent bulk modulus of the acoustic capsule of the Nth layer of material; d p and d q are the actual thicknesses of the p-th and q-th layers, respectively.
[0008] Furthermore, the multilayer material of the capsule shell layer is composed of two materials, material A and material B, and the equivalent parameters of the multilayer material and the applied acoustic radiation force meet the following design requirements: , In the formula, ρ A and ρ B are the densities of material A and material B, respectively, k A and k B are the bulk moduli of material A and material B, respectively, and d A and d B are the total thickness of material A and material B respectively, and η is the thickness ratio of material A to material B.
[0009] Furthermore, the total thickness of the capsule shell is on the same scale as the wavelength of the sound wave.
[0010] Beneficial effects: Compared with the prior art, the present invention utilizes the design of equivalent parameters to achieve the same acoustic radiation force in the sound field for an acoustic transport capsule carrying any object, and greatly improves the versatility of the acoustic radiation force transport scheme. The same acoustic transport capsule can be used to transport different contents.
[0011] The universal design of the present invention greatly reduces costs, making it possible to realize large-scale medical and industrial applications of fine manipulation of objects transported by acoustic radiation force. In medicine, acoustic radiation force capsules carrying different drugs can reach the lesions at the same time under the control of acoustic radiation force, thereby greatly improving the treatment efficiency and effect. BRIEF DESCRIPTION OF THE DRAWINGS
[0012] Figure 1 It is a schematic diagram of the structure of the acoustic transport capsule based on metamaterials described in the present invention.
[0013] Figure 2 Graphs 1 and 2 are the acoustic field distributions of acoustic capsules carrying CaBr2 particles at different equivalent densities and acoustic velocities according to an embodiment of the present invention.
[0014] Figure 3 Graphs 1 and 2 are the acoustic field distributions of acoustic capsules carrying glycerol particles of different equivalent densities and acoustic velocities according to an embodiment of the present invention.
[0015] Figure 4 Graphs 1 and 2 are acoustic field distributions of acoustic capsules carrying protein particles at different equivalent densities and acoustic velocities according to an embodiment of the present invention.
[0016] Figure 5 1 is the acoustic radiation force of the acoustic capsule structure with different equivalent parameters when carrying and transporting substances in the embodiments of the present invention, wherein: (a) is CaBr2 particles, (b) is glycerol particles, and (c) is protein particles.
[0017] Figure 6The acoustic radiation force obtained by the acoustic capsules with different equivalent densities and equivalent sound velocities under different spectrum conditions in the embodiments of the present invention is obtained based on the theoretical solution and finite element simulation, where: (a) the incident sound wave number k = 2500 kg / m 3 , the outer diameter of the acoustic capsule b = 2500m / s; (b) the incident sound wave number k = 3000kg / m 3 , the outer diameter of the acoustic capsule is b=3000m / s. DETAILED DESCRIPTION
[0018] The present invention is further explained below in conjunction with the accompanying drawings and specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. After reading the present invention, various equivalent forms of modifications to the present invention by those skilled in the art all fall within the scope defined by the claims attached to this application.
[0019] The acoustic transport capsule based on metamaterials of the present invention adopts the equivalent parameter principle. For periodic layered structures, when the wavelength of the sound wave is much larger than the thickness of a single layer, the anisotropy of density can be realized through the equivalent parameters. The anisotropy of density is used to achieve parameter modulation, thereby shielding the sound field in the internal transport structure area, thereby eliminating the interaction between the internal transported structure and the sound field, so that the sound radiation force obtained by the whole composed of the acoustic transport capsule and the internal transport structure is only related to the equivalent parameters of the acoustic transport capsule, which is the key innovation of the present invention.
[0020] The structural samples of the present invention are as follows Figure 1 As shown in the figure, the exterior of the acoustic capsule structure is composed of a multi-layer concentric spherical shell structure, and the interior is a cavity that can carry any transported object. The acoustic radiation force on the designed acoustic capsule and the object it carries is related to the equivalent parameters of the acoustic capsule and meets the following design requirements:
[0021] (1) The equivalent parameters (equivalent density, equivalent bulk modulus) of the acoustic capsule structure are designed as follows: , In the formula, ρ r represents the equivalent density of the acoustic capsule in the axial direction; ρ θ represents the equivalent density of the acoustic capsule in the lateral direction; ρ N represents the density of the Nth layer of material, η N represents the relative thickness of the Nth layer of material, κappa represents the equivalent bulk modulus of the acoustic capsule, κappa_N represents the equivalent bulk modulus of the acoustic capsule of the Nth layer of material, d p and d q are the actual thicknesses of the p-th and q-th layers, respectively.
[0022] (2) Under the equivalent parameters of the above acoustic capsule structure, the acoustic radiation force F acting on the acoustic capsule meets the following requirements: , Where F represents the acoustic radiation force on the acoustic capsule; p is the pressure; p0 is the ambient pressure; s represents the outer surface of the acoustic capsule; The unit vector representing the propagation direction of the incident sound wave; z represents the direction of the incident sound wave; c0 represents the sound speed of the ambient medium; ρ0 represents the density of the ambient medium; Represents the total velocity potential of the acoustic field where the acoustic capsule is located.
[0023] (3) Thickness d of each layer of acoustic capsule material p and d q It needs to be much smaller than the wavelength of the sound wave and needs to be arranged periodically, that is, after the material layers of different materials are stacked in sequence, they are stacked periodically in the same order. Taking two types of materials A and B as an example, the arrangement method needs to be ABABAB..., and taking three types of materials A, B, and C as an example, the arrangement method is ABCABCABC...
[0024] Taking the acoustic capsule composed of two types of materials A and B as an example, the equivalent parameter (equivalent density, equivalent bulk modulus) design is simplified as follows: , Here, ρ A and ρ B are the densities of material A and material B, respectively, k A and k B are the bulk moduli of material A and material B, respectively, and d A and d B are the total thickness of material A and material B respectively, and η is the thickness ratio of material A to material B.
[0025] In order to verify the effectiveness and feasibility of the invention, we conducted finite element simulation. In the simulation scheme, two materials A and B are used to construct the acoustic transport capsule, and the thickness ratio is set to 1:1. The simulation uses a 50-layer repeated structure to construct the acoustic transport capsule. The frequency of the incident sound wave is 2MHZ, and the simulation uses five large-span parameter combinations for verification: 1. The equivalent density is 2000kg / m 3 , the equivalent speed of sound is 2500m / s; 2. The equivalent density is 2500 kg / m 3 , the equivalent speed of sound is 2500 m / s; 3. The equivalent density is 2500 kg / m 3 , the equivalent speed of sound is 3000 m / s; 4. The equivalent density is 3000 kg / m 3 , the equivalent speed of sound is 2500m / s; 5. The equivalent density is 3000 kg / m3 , the equivalent speed of sound is 3000 m / s.
[0026] like Figure 2 As shown in the figure, the acoustic field distribution of the acoustic capsule with different equivalent density and sound speed carrying CaBr2 particles, the equivalent parameters are as follows: (a1) equivalent density is 2000kg / m 3 , the equivalent speed of sound is 2500 m / s; (b1) the equivalent density is 2500 kg / m 3 , the equivalent speed of sound is 2500 m / s; (c1) the equivalent density is 2500 kg / m 3 , the equivalent sound speed is 3000 m / s; (d1) the equivalent density is 3000 kg / m 3 , the equivalent sound speed is 2500 m / s; (e1) the equivalent density is 3000 kg / m 3 , the equivalent sound speed is 3000 m / s. (𝑎2), (𝑏2)…(𝑒2) are the control group, the particles are not placed in the acoustic capsule and are directly exposed to the sound field.
[0027] Figure 3 As shown in the figure, the acoustic field distribution of the acoustic capsule with different equivalent density and sound speed carrying glycerol particles, the equivalent parameters are as follows: (a1) equivalent density is 2000kg / m 3 , the equivalent speed of sound is 2500m / s; (b1) the equivalent density is 2500kg / m 3 , the equivalent sound speed is 2500m / s; (c1) the equivalent density is 2500kg / m 3 , the equivalent speed of sound is 3000m / s; (d1) the equivalent density is 3000kg / m 3 , the equivalent sound speed is 2500m / s; (e1) the equivalent density is 3000kg / m 3 , the equivalent sound speed is 3000m / s. (𝑎2), (𝑏2)…(𝑒2) are the control group, the particles are not placed in the acoustic capsule and are directly exposed to the sound field.
[0028] Figure 4 As shown in the figure, the acoustic field distribution of the acoustic capsule with different equivalent density and sound speed carrying protein particles, the equivalent parameters are as follows: (a1) equivalent density is 2000kg / m 3 , the equivalent speed of sound is 2500m / s; (b1) the equivalent density is 2500kg / m 3 , the equivalent sound speed is 2500m / s; (c1) the equivalent density is 2500kg / m 3 , the equivalent speed of sound is 3000m / s; (d1) the equivalent density is 3000kg / m 3 , the equivalent sound speed is 2500m / s; (e1) the equivalent density is 3000kg / m 3, the equivalent sound speed is 3000m / s. (𝑎2), (𝑏2)…(𝑒2) are the control group, the particles are not placed in the acoustic capsule and are directly exposed to the sound field.
[0029] From the above finite element simulation result diagram, it can be seen that the left side of each comparison diagram is the sound field distribution diagram when the acoustic capsule with specific equivalent parameters is used to carry the transported object, and the right side is the sound field distribution diagram when the transported object is directly exposed to the ambient sound field. It can be seen that the acoustic transport capsule realizes the internal shielding of the sound field, and the acoustic radiation force received by the acoustic transport capsule and the transported object as a whole is only related to the design equivalent parameters of the acoustic transport capsule. Therefore, based on the design of the equivalent parameters of the acoustic transport capsule of the present invention, standardized and precise manipulation of various particles can be achieved.
[0030] Figure 5 As shown, the acoustic radiation force of acoustic capsule structures with different equivalent parameters when carrying (a) CaBr2 particles, (b) glycerol particles and (c) protein particles.
[0031] Figure 6 As shown in the figure, acoustic radiation forces are obtained by different equivalent densities and equivalent sound speeds of acoustic capsules obtained by theoretical solution and finite element simulation in different spectrum situations. Among them: (a) equivalent density is 2500kg / m3, equivalent sound speed is 2500m / s; (b) equivalent density is 3000kg / m3, equivalent sound speed is 3000m / s, k is the wave number of the incident sound wave, and b is the outer diameter of the acoustic capsule.
[0032] pass Figure 5 and 6 The acoustic radiation force of the acoustic transport capsule obtained by finite element simulation under different design parameters can be used to select appropriate equivalent parameter designs to obtain the expected acoustic radiation force.
[0033] The acoustic capsule of the present invention is designed based on the equivalent anisotropy of density and sound velocity. The designed acoustic capsule realizes internal shielding of the sound field, that is, any object carried is subjected to the same acoustic radiation force. This design makes it possible to achieve precise manipulation of particles with different parameters based on acoustic radiation force. Based on the acoustic capsule, a unified and intensive particle manipulation scheme can be designed for particles with different parameters, which has broad application prospects in the directional transport and targeted drug delivery in the fields of life sciences and medicine.
[0034] The above descriptions are only some embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.
Claims
1. An acoustic transport capsule based on metamaterials, characterized in that: The acoustic transport capsule is a layered spherical structure, including a capsule shell layer formed by stacking multiple material layers based on the equivalent parameter method, and an inner cavity located in the capsule shell layer for carrying the transported object. The acoustic transport capsule can realize acoustic transport as a whole under the action of externally applied acoustic radiation force.
2. The metamaterial-based acoustic transport capsule according to claim 1, characterized in that: The multilayer material layer comprises at least two or more different materials. The material layers of different materials are stacked in sequence and then periodically and repeatedly stacked in the same order; and the thickness of each material layer is less than 1 / 10 of the wavelength of the sound wave.
3. The metamaterial-based acoustic transport capsule according to claim 2, characterized in that: The equivalent parameters of the multilayer materials of the capsule shell and the applied acoustic radiation force meet the following design requirements: ， In the formula, F represents the acoustic radiation force on the acoustic capsule; ρ0 represents the density of the ambient medium; c0 represents the sound velocity of the ambient medium; represents the total velocity potential of the acoustic field where the acoustic capsule is located; The unit vector representing the propagation direction of the incident sound wave; s represents the outer surface of the acoustic capsule; z represents the propagation direction of the incident sound wave; t represents time; The total velocity potential of the acoustic field where the acoustic capsule is located , calculated by the following formula, ， In the formula, represents the total velocity potential of the acoustic field where the acoustic capsule is located; is the velocity potential of the incident sound wave; is the velocity potential of scattered sound waves; is the amplitude of the incident sound wave velocity potential; w is the circular frequency of the incident sound wave; i is the imaginary unit; is the nth-order Legendre function; is the nth-order spherical Bessel function of the first kind; is the zenith angle parameter of the spherical coordinates, k represents the wave number of the incident wave, and r is the outer diameter of the acoustic capsule; A n,s is the equivalent scattering coefficient of the acoustic capsule; Equivalent scattering coefficient A of acoustic capsule n,s , then we get the following formula: ， In the formula, A n,s is the equivalent scattering coefficient of the acoustic capsule, x, x1, x2 are intermediate quantities of variable substitution, c d is the equivalent radial sound velocity of the acoustic capsule, c s h is the equivalent transverse sound velocity of the acoustic capsule; n (x) represents the n-th order spherical Hankel function; represents the derivative of the variable; ρ0 represents the density of the ambient medium; ρ r represents the equivalent density of the acoustic capsule in the axial direction; ρ θ represents the equivalent density of the acoustic capsule in the lateral direction; κappa represents the equivalent bulk modulus of the acoustic capsule; ， In the formula, ρ r represents the equivalent density of the acoustic capsule in the axial direction; ρ θ represents the equivalent density of the acoustic capsule in the lateral direction; ρ N represents the density of the Nth layer of material, η N represents the relative thickness of the Nth layer of material, κappa represents the equivalent bulk modulus of the acoustic capsule, and κappa_N represents the equivalent bulk modulus of the acoustic capsule of the Nth layer of material; d p and d q are the actual thicknesses of the p-th and q-th layers, respectively.
4. The metamaterial-based acoustic transport capsule according to claim 3, characterized in that: The multilayer material of the capsule shell layer is composed of two materials, material A and material B. The equivalent parameters of the multilayer material and the applied acoustic radiation force meet the following design requirements: ， In the formula, ρ A and ρ B are the densities of material A and material B, respectively, k A and k B are the bulk moduli of material A and material B, respectively, and d A and d B are the total thickness of material A and material B respectively, and η is the thickness ratio of material A to material B.
5. The metamaterial-based acoustic transport capsule according to claim 2, characterized in that: The total thickness of the capsule shell is on the same scale as the wavelength of the sound waves.