Pyriproxyfen-buprofezin dispersible oil suspending agent and preparation method thereof

Abstract

The invention relates to the technical field of pesticides, in particular to a pyriproxyfen-buprofezin dispersible oil suspending agent and a preparation method thereof.The pyriproxyfen-buprofezin dispersible oil suspending agent is prepared from, by weight, 3-10 parts of pyriproxyfen active compound, 10-20 parts of buprofezin active compound, 2-10 parts of nonionic-anionic compound emulsifier, 2-10 parts of dispersing agent, 0.1-2 parts of stabilizer and 20-50 parts of dispersion medium, by compounding pyriproxyfen and buprofezin according to the mass ratio of 1: (2-4), especially compounding according to the mass ratio of 1: 3, under the matching action of other auxiliaries in a system, the insecticidal composition has a good control effect on pests on fruit trees, vegetables, grain crops, fiber crops and legume crops, and especially has the fast-acting property and the persistent effect of controlling tomato bemisia tabaci obviously higher than those of a single-component preparation.

Description

Technical Field

[0001] The invention relates to the technical field of pesticides, in particular to a pyriproxyfen-buprofezin dispersible oil suspension and a preparation method thereof. Background Art

[0002] Pyriproxyfen is an alkoxypyridine juvenile hormone chitin synthesis inhibitor. It inhibits the synthesis of chitin in insects by affecting the metamorphosis and reproduction of insects, interferes with insect metabolism, and causes the growth and development of pests to be deformed and die. In addition, pyriproxyfen also has a good egg-killing effect, which can prevent the normal development of pests. Buprofezin is also an insect growth regulator insecticide, which interferes with its normal growth and development by inhibiting the synthesis of insect chitin. Buprofezin has a strong selectivity for pests, mainly for whiteflies, planthoppers, leafhoppers and scale insects of Hemiptera. Pyriproxyfen and buprofezin are usually used as compound components with other pesticides. A Chinese patent (publication number CN103858896A) discloses a synergistic method for preventing and controlling pests and diseases, and compounding cyclohexidine with pyriproxyfen or buprofezin. When propyl ether and buprofezin are compounded, the two can play a synergistic role, enhance the insecticidal effect, and expand the scope of prevention and control. A Chinese patent (authorization announcement number CN103385251B) discloses an insecticide composition containing pyriproxyfen, which discloses that pyriproxyfen is combined with any one of indoxacarb, buprofezin, isoprocarb, mefenamic acid, and carbaryl to control pests on fruit trees, vegetables, grain crops, fiber crops, and legume crops. However, there are large differences in the stability and biological activity of the pesticide original drug under different dosage forms. The suspension system is a kinetically unstable system, especially for the pyriproxyfen·buprofezin original drug combination, and it is of great practical significance to develop a stable dispersible oil suspension containing the pyriproxyfen·buprofezin original drug combination that meets the use requirements. Summary of the invention

[0003] On the one hand, the present invention provides a pyriproxyfen-buprofezin dispersible oil suspension, which comprises, by weight, 3-10 parts of pyriproxyfen technical drug, 10-20 parts of buprofezin technical drug, 2-10 parts of nonionic-anionic composite emulsifier, 2-10 parts of dispersant, 0.1-2 parts of stabilizer and 20-50 parts of dispersion medium.

[0004] As a preferred technical solution, the mass ratio of the pyriproxyfen technical and the thiazide technical is 1:(2-4), preferably 1:3.

[0005] The present invention compounds pyriproxyfen and buprofezin at a mass ratio of 1: (2-4), especially 1: 3, and with the cooperation of other adjuvants in the system, has good control effects on pests on fruit trees, vegetables, grain crops, fiber crops and bean crops, especially the quick-acting and lasting effects of controlling tomato whiteflies are significantly higher than those of single-ingredient preparations.

[0006] As a preferred technical solution, the nonionic-anionic composite emulsifier includes at least fatty alcohol polyoxyethylene ether emulsifier and alkylbenzene sulfonate emulsifier.

[0007] The HLB value of the fatty alcohol polyoxyethylene ether emulsifier is 10-15, preferably 10-12, most preferably 11.6, and the model is Nouryon 1005.

[0008] As a preferred technical solution, the alkylbenzene sulfonate emulsifier is sodium dodecylbenzene sulfonate.

[0009] As a preferred technical solution, the mass ratio of the fatty alcohol polyoxyethylene ether emulsifier to the alkylbenzene sulfonate emulsifier is (1-2):(3-5), preferably 1:2.

[0010] As a preferred technical solution, the dispersant is selected from at least one of alkylphenol polyoxyethylene ether, benzylphenol polyoxyethylene ether, and phenethylphenol polyoxyethylene ether, preferably triphenethylphenol polyoxyethylene ether, Nantong Landuo New Materials Co., Ltd., Landuo 600#.

[0011] As a preferred technical solution, the amount of the stabilizer used is 0.8-1.2 parts by weight.

[0012] As a preferred technical solution, the stabilizer is selected from at least one of organic bentonite, white carbon black, kaolin, magnesium aluminum silicate, carboxymethyl cellulose, light calcium powder, and talc, preferably organic bentonite.

[0013] Preferably, the particle size of the organobentonite is 200-500 mesh, preferably 325 mesh.

[0014] As a preferred technical solution, the mass ratio of the nonionic-anionic composite emulsifier, dispersant and stabilizer is (5-7): (5-7): 1, preferably 6:6:1.

[0015] As a preferred technical solution, the dispersion medium is selected from one of methyl oleate, soybean oil, corn oil, solvent oil, paraffin oil, mineral oil, and biodiesel, preferably methyl oleate.

[0016] The selection of pesticide formulation is not only determined by the properties of the original drug, but also needs to be considered in combination with safety, environmental protection, labor saving and other factors. Since there are few studies on dispersible oil suspensions, most of them are prepared and screened for adjuvants in imitation of water suspensions. However, due to the large difference in properties between water-based and oil-based, many adjuvants suitable for water-based have little effect in oil-based. Therefore, there are great technical challenges in the development of pyriproxyfen-buprofezin dispersible oil suspensions.

[0017] During the development process of the present invention, it was found that by optimizing the selection and combination of the nonionic-anionic compound emulsifier, dispersant and stabilizer in the system, and further controlling the mass ratio of the nonionic-anionic compound emulsifier, dispersant and stabilizer in the system to (5-7): (5-7): 1, the stability of the product is ensured, the effective ingredients are protected, the drift of droplets is reduced, the adhesion, permeability and wetting and spreading of droplets on the surface of crops are improved, the control effect of the agent is improved, the utilization rate of pesticides is increased, and the effective period is extended.

[0018] Specifically, the present invention adopts sodium dodecylbenzene sulfonate and Nouryon 1005 is a nonionic-anionic composite emulsifier system composed of (3-5): (1-2) by mass ratio, and is combined with triphenylethylphenol polyoxyethylene ether to ensure product stability, avoid oil separation, stratification and other phenomena, ensure the use effect of the product after subsequent water addition, and can also reduce the grinding time in the product preparation process and improve the grinding efficiency. The use of other nonionic-anionic composite emulsifier systems or other dispersants will cause the suspension system to be unstable during long-term storage.

[0019] Furthermore, the present invention controls the mass ratio of the nonionic-anionic composite emulsifier, the dispersant, and the stabilizer in the system to be (5-7): (5-7): 1, and especially introduces an organic bentonite with a particle size of 200-500 mesh as a stabilizer. Under the joint action of methyl oleate in the system, the viscosity and pourability of the product are balanced, the processing difficulty is reduced, the use effect is improved, the oil separation, bottoming and the like are avoided, and the stability of the dispersible oil suspension is further improved. However, if the addition amount of other stabilizers or organic bentonite is too high, a good stabilizing effect cannot be achieved.

[0020] On the other hand, the present invention provides a method for preparing a pyriproxyfen-buprofezin dispersible oil suspension, which comprises at least the following steps: stirring pyriproxyfen technical, buprofezin technical, nonionic-anionic composite emulsifier, dispersant, stabilizer and dispersion medium into a slurry, and sand-milling the slurry for 1-1.5 hours using a sand mill to obtain the slurry.

[0021] The pyriproxyfen-buprofezin dispersible oil suspension product provided by the present invention has high stability, good applicability for pesticide application in special terrains and regions, can be combined with drone pesticide application, overcomes the shortcomings of easy evaporation and drift of water-based formulations when using drones for pesticide application, and has high practical application value.

[0022] Beneficial Effects

[0023] 1. The present invention compounds pyriproxyfen and thiamethoxam in a mass ratio of 1: (2-4), especially 1: 3, and with the cooperation of other adjuvants in the system, has good control effects on pests on fruit trees, vegetables, grain crops, fiber crops, and legume crops, especially the rapid effect and long-lasting effect of controlling tomato whitefly are significantly higher than those of single-ingredient preparations.

[0024] 2. The present invention ensures the stability of the product, protects the active ingredients, reduces the drift of droplets, improves the adhesion, permeability and wetting and spreading of droplets on the crop surface, enhances the control effect of the agent, improves the utilization rate of pesticides, and prolongs the effective period by selecting and combining nonionic-anionic compound emulsifiers, dispersants and stabilizers in the optimal system, and further controls the mass ratio of the nonionic-anionic compound emulsifiers, dispersants and stabilizers in the system to (5-7): (5-7): 1.

[0025] 3. The present invention adopts sodium dodecylbenzene sulfonate and Nouryon 1005 is a nonionic-anionic composite emulsifier system composed of (3-5): (1-2) by mass ratio, and is combined with triphenylethylphenol polyoxyethylene ether to ensure product stability, avoid oil separation, stratification and other phenomena, ensure the use effect of the product after subsequent water addition, and can also reduce the grinding time in the product preparation process and improve the grinding efficiency. The use of other nonionic-anionic composite emulsifier systems or other dispersants will cause the suspension system to be unstable during long-term storage.

[0026] 4. The present invention controls the mass ratio of the nonionic-anionic composite emulsifier, the dispersant and the stabilizer in the system to be (5-7): (5-7): 1, and especially introduces an organic bentonite with a particle size of 200-500 mesh as a stabilizer. Under the joint action of methyl oleate in the system, the viscosity and pourability of the product are balanced, the processing difficulty is reduced, the use effect is improved, the oil separation, bottoming and the like are avoided, and the stability of the dispersible oil suspension is further improved. However, if the addition amount of other stabilizers or organic bentonite is too high, a good stabilizing effect cannot be achieved.

[0027] 5. The pyriproxyfen-buprofezin dispersible oil suspension product provided by the present invention has high stability and good applicability for application in special terrains and regions. It can be combined with drone application to overcome the shortcomings of easy evaporation and drift of water-based formulations when using drones for application, and has high practical application value. DETAILED DESCRIPTION

[0028] Example 1

[0029] Embodiment 1 of the present invention provides a pyriproxyfen-buprofezin dispersible oil suspension, which comprises, by weight: 5.15 parts of 98wt% pyriproxyfen technical, 15.3 parts of 98wt% buprofezin technical, 6 parts of nonionic-anionic composite emulsifier, 6 parts of dispersant, 1 part of stabilizer, and 33.5 parts of dispersion medium.

[0030] 98wt% pyriproxyfen technical was from Jiangsu Kuaida Agrochemical Co., Ltd., CAS: 95737-68-1.

[0031] 98wt% of thiamethoxam technical was from Jiangsu Changlong Agrochemical Co., Ltd., with a CAS number of 69327-76-0.

[0032] The nonionic-anionic composite emulsifier is a combination of a fatty alcohol polyoxyethylene ether emulsifier and an alkylbenzene sulfonate emulsifier.

[0033] The HLB value of the fatty alcohol polyoxyethylene ether emulsifier is 11.6, and the model is Nouryon 1005.

[0034] The alkylbenzene sulfonate emulsifier is sodium dodecylbenzene sulfonate (Suzhou Yichu Chemical Technology Co., Ltd.; CAS: 25155-30-0).

[0035] The mass ratio of the fatty alcohol polyoxyethylene ether emulsifier to the alkylbenzene sulfonate emulsifier is 1:2.

[0036] The dispersant is triphenylethylphenol polyoxyethylene ether, Nantong Landuo New Materials Co., Ltd., Landuo 600#.

[0037] The stabilizer is organic bentonite (Hebei Zhuofei Mineral Products Co., Ltd., zf88, 325 mesh)

[0038] The dispersion medium is methyl oleate (Hebei Mirun Biotechnology Co., Ltd.; CAS: 112-62-9).

[0039] On the other hand, Example 1 of the present invention provides a method for preparing a pyriproxyfen-buprofezin dispersible oil suspension, which specifically comprises the following steps: stirring pyriproxyfen technical, buprofezin technical, nonionic-anionic composite emulsifier, dispersant, stabilizer, and dispersion medium into a slurry, and sand-milling the slurry with a sand mill for 1.5 hours to obtain the slurry.

[0040] Example 2

[0041] On the one hand, Example 2 of the present invention provides a pyriproxyfen·buprofen dispersible oil suspension, and its specific implementation method is the same as that of Example 1, except that, in parts by weight, the pyriproxyfen·buprofen dispersible oil suspension comprises: 3 parts of 98wt% pyriproxyfen technical drug, 10 parts of 98wt% buprofen technical drug, 2 parts of non-ionic-anionic composite emulsifier, 2 parts of dispersant, 0.1 parts of stabilizer, and 20 parts of dispersion medium.

[0042] Example 3

[0043] On the one hand, Example 2 of the present invention provides a pyriproxyfen·buprofen dispersible oil suspension, and its specific implementation method is the same as that of Example 1, except that, by weight, the pyriproxyfen·buprofen dispersible oil suspension comprises: 10 parts of 98wt% pyriproxyfen technical drug, 20 parts of 98wt% buprofen technical drug, 10 parts of non-ionic-anionic composite emulsifier, 10 parts of dispersant, 2 parts of stabilizer, and 50 parts of dispersion medium.

[0044] Comparative Example 1

[0045] Comparative Example 1 of the present invention provides a pyriproxyfen·buprofen dispersible oil suspension and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that, in parts by weight, the pyriproxyfen·buprofen dispersible oil suspension comprises: 5.15 parts of pyriproxyfen technical, 15.3 parts of buprofen technical, 6.5 parts of nonionic-anionic composite emulsifier, 6.5 parts of dispersant, 0 parts of stabilizer, and 33.5 parts of dispersion medium, and the mass ratio of the fatty alcohol polyoxyethylene ether emulsifier to the alkylbenzene sulfonate emulsifier is 2:4.5.

[0046] Comparative Example 2

[0047] Comparative Example 2 of the present invention provides a pyriproxyfen·buprofen dispersible oil suspension and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that, in parts by weight, the pyriproxyfen·buprofen dispersible oil suspension comprises: 5.15 parts of pyriproxyfen technical drug, 15.3 parts of buprofen technical drug, 10 parts of nonionic-anionic composite emulsifier, 0 parts of dispersant, 3 parts of stabilizer, and 33.5 parts of dispersion medium, and the mass ratio of the fatty alcohol polyoxyethylene ether emulsifier to the alkylbenzene sulfonate emulsifier is 2:8.

[0048] Comparative Example 3

[0049] Comparative Example 3 of the present invention provides a pyriproxyfen·buprofen dispersible oil suspension and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that, by weight, the pyriproxyfen·buprofen dispersible oil suspension comprises: 5.15 parts of pyriproxyfen technical drug, 15.3 parts of buprofen technical drug, 2 parts of nonionic-anionic composite emulsifier, 9 parts of dispersant, 2 parts of stabilizer, and 33.5 parts of dispersion medium, and the nonionic-anionic composite emulsifier is replaced by a fatty alcohol polyoxyethylene ether emulsifier (Nouryon 1005).

[0050] Comparative Example 4

[0051] Comparative Example 4 of the present invention provides a pyriproxyfen-buprofezin dispersible oil suspension and a preparation method thereof, and its specific implementation manner is the same as that of Example 1, except that the sodium dodecylbenzene sulfonate is replaced by sodium fatty alcohol polyoxyethylene ether sulfate (Shandong Binsheng New Materials Technology Co., Ltd. 06091022).

[0052] Comparative Example 5

[0053] Comparative Example 5 of the present invention provides a pyriproxyfen-buprofezin dispersible oil suspension and a preparation method thereof, and its specific implementation manner is the same as that of Example 1, except that the organic bentonite is replaced by carboxymethyl cellulose (ZRHH-142, Shandong Zhongrun Haihua Chemical Technology Co., Ltd.).

[0054] Comparative Example 6

[0055] Comparative Example 6 of the present invention provides a pyriproxyfen-buprofezin dispersible oil suspension and a preparation method thereof, and its specific implementation manner is the same as that of Example 1, except that the triphenylethylphenol polyoxyethylene ether is replaced by triphenylethylenephenol polyoxyethylene ether phosphate (600#P from Hai'an Petrochemical Plant, Jiangsu Province).

[0056] Performance Testing

[0057] 1. Conduct field efficacy tests on the product provided in Example 1.

[0058] 1 Basic information of the test

[0059] 1.1 Test name

[0060] Field test on the efficacy of 20% pyriproxyfen·buprofen dispersible oil suspension to control tomato whitefly

[0061] 1.2 Purpose of the experiment

[0062] Through field efficacy tests, the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension on tomato whitefly and its safety on tomatoes were clarified, providing a scientific basis for the pesticide registration and field application of this product.

[0063] 1.3 Test basis

[0064] "Quality Management Standards for Pesticide Registration Tests", "Quality Management Standards for Pesticide Registration Field Efficacy Tests" (NY / T2885-2016), "Guidelines for Pesticide Field Efficacy Tests" (NY / T 1464.43-2012), "Standard Operating Procedures for Field Efficacy Tests of Insecticides for Control of Vegetable Whiteflies" (CRI-SOP-I-028)

[0065] 3. Environment and facility cultivation conditions

[0066] 3.1 Test site information, see Table 1.

[0067] Table 1

[0068]

[0069]

[0070] 3.2 Meteorological data, see Table 2.

[0071] Table 2

[0072] Date of application Maximum temperature(℃) Minimum temperature (℃) Weather conditions Wind direction and wind force 2023-09-28 25 21 Sunny to cloudy Northwest wind level 1

[0073] 4 Experimental design and arrangement

[0074] 4.1 Dosage and number of medicines

[0075] The experimental design of the test agent is shown in Table 3.

[0076] Table 3

[0077]

[0078] 4.2 Community Arrangement

[0079] 4.2.1 Cell Arrangement

[0080] The plots were arranged in random blocks, with protection rows between cells. See Table 4 for a schematic diagram of the plots.

[0081] Table 4

[0082]

[0083]

[0084] 4.2.2 Plot area and repetition

[0085] Area: 20m 2 .

[0086] Number of replicates: 4 replicates (plots) per treatment.

[0087] 4.3 Application method

[0088] 4.3.1 Period and method of use

[0089] Test period: The test was from the early to the peak period of egg-laying of tomato whiteflies, and tomatoes were in the seedling stage.

[0090] Application method: Use spray method, secondary dilution, and proceed from low to high concentration. First, pour half of the water into the sprayer, then pour the solution mixed with water, clean the bottle, and finally pour the remaining water. Spray the solution evenly and thoroughly on the front and back of the leaves and stems.

[0091] 4.3.2 Application equipment

[0092] The test used a Weishi WS-18D electric sprayer (produced by Shandong Weishi Plant Protection Machinery Co., Ltd.), numbered E-DDPWQ03 (insects and bacteria)-04, with a working pressure of 0.15-0.4MPa; a round nozzle with a specification of M14X1.5. The average flow rate of the sprayer was 1.33L / min, and the maximum error was 1.1%.

[0093] 4.3.3 Application time and frequency

[0094] The test was conducted on September 28, 2023, with one application.

[0095] 4.3.4 Usage capacity

[0096] The dosage of the solution is 45L / mu.

[0097] 4.4 Survey methods, time and frequency

[0098] 4.4.1 Survey time and frequency

[0099] Investigate the insect population base before applying the pesticide, and investigate the insect population on fixed plants 1 day, 3 days, 7 days, 14 days, and 21 days after applying the pesticide.

[0100] 4.4.2 Survey Methods

[0101] Ten crops were randomly selected in each plot, and the number of live adults on the entire plant was investigated in the morning when the adults were inactive.

[0102] 4.4.3 Calculation method of drug efficacy

[0103]

[0104]

[0105] The arcsine square root transformed values ​​of the control efficacy against whitefly were subjected to variance analysis (SPSS20.0 statistical software), and the new multiple range method was used to compare whether there were significant differences in the average control efficacy of each agent at the P value of 0.05 and 0.01 levels.

[0106] 4.5 Direct impact on crops

[0107] Within the test dosage range, observe whether the pesticide causes phytotoxicity to tomato leaves and stems.

[0108] 4.6 Product quality and output

[0109] Not required.

[0110] 4.7 Impact on other organisms

[0111] Observe whether the agent has adverse effects on natural enemies.

[0112] 5 Test results and analysis

[0113] The control effect of 20% pyriproxyfen·buprofezin dispersible oil suspension on tomato whitefly is shown in Table 5.

[0114] Table 5 Results of the efficacy test of 20% pyriproxyfen·buprofezin dispersible oil suspension against tomato whitefly

[0115]

[0116]

[0117] Note: The protective effect (%) in the above table is the average of each replicate. Different lowercase and uppercase letters after the data in the same column indicate differences at the 0.05 and 0.01 levels, respectively. The significance was determined using the Duncan's new multiple range (DMRT) method.

[0118] Analyzing the above table:

[0119] One day after application, the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 40 ml / mu on tomato whitefly was significantly lower than that of the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu, and was not significantly different from the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu; the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at dosages of 50 ml / mu and 60 ml / mu on tomato whitefly was not significantly different from the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu and 40% buprofen suspension preparation at a dosage of 25 ml / mu.

[0120] Three days after the application of the medicine, the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 40 ml / mu on tomato whiteflies was not significantly different from that of the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu and 40% buprofen suspension preparation at a dosage of 25 ml / mu; the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 50 ml / mu and 60 ml / mu on tomato whiteflies was extremely significantly better than that of the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu, and was not significantly different from the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu.

[0121] 7 days after application, the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 40 ml / mu on tomato whiteflies was not significantly different from that of the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu, and was significantly lower than the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu; the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 50 ml / mu and 60 ml / mu on tomato whiteflies was significantly better than the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu and 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu.

[0122] 14 days after application, the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 40 ml / mu on tomato whitefly was significantly lower than that of the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu, and was not significantly different from the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu; the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 50 ml / mu and 60 ml / mu on tomato whitefly was extremely significantly better than that of the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu and 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu.

[0123] 21 days after application, the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 40 ml / mu on tomato whitefly was not significantly different from that of the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu and 40% buprofen suspension preparation at a dosage of 25 ml / mu; the control effect of 20% pyriproxyfen·buprofen dispersible oil suspension preparation at a dosage of 50 ml / mu and 60 ml / mu on tomato whitefly was significantly better than that of the control agent 40% buprofen suspension preparation at a dosage of 25 ml / mu, and was not significantly different from the control agent 100 g / L pyriproxyfen emulsifiable concentrate preparation at a dosage of 50 ml / mu.

[0124] No phytotoxicity to tomatoes was found within the test dosage range, and no adverse effects were found on natural enemies, so the agent can be used in production.

[0125] 6 Conclusion

[0126] The results of field tests show that the dosage of 20% pyriproxyfen·buprofen dispersible oil suspension preparation is 50-60 ml / mu, which has a good control effect, and 40 ml / mu has a relatively poor control effect. The recommended dosage is 50-60 ml / mu (effective ingredient dosage 150-180 g / hectare), which should be sprayed from the early egg-laying stage to the beginning of the peak period of tomato whitefly. In order to delay the development of resistance, different modes of action should be used alternately.

[0127] 2. The physical and chemical properties of the suspension concentrate product provided in Example 1 were tested, with reference to NY / T 1860-2016 "Test Guidelines for Determination of Physical and Chemical Properties of Pesticides", and the test items and test results are shown in Table 6.

[0128] Table 6

[0129]

[0130] 3. Place the suspension products provided in the examples and comparative examples in 50 mL centrifuge tubes ( 50mL PP centrifuge tube, self-standing, with sealing cap, outer diameter 29.1mm, length 114.9mm), stand at 25°C for 0-72h, and record the appearance of the product. Evaluation criteria: transition layer 50-90mm thickness is slight stratification, transition layer 20-50mm thickness is stratification, and transition layer 0-20mm thickness is severe stratification. The results are shown in Table 7.

[0131] Table 7

[0132]

Claims

1. A pyriproxyfen-buprofezin dispersible oil suspension, characterized in that: Calculated by weight, the composition comprises: 3-10 parts of pyriproxyfen technical, 10-20 parts of thiamethoxam technical, 2-10 parts of nonionic-anionic composite emulsifier, 2-10 parts of dispersant, 0.1-2 parts of stabilizer and 20-50 parts of dispersion medium.

2. The pyriproxyfen-buprofezin dispersible oil suspension according to claim 1, characterized in that: The mass ratio of the pyriproxyfen technical drug to the thiazide technical drug is 1:(2-4).

3. The pyriproxyfen-buprofezin dispersible oil suspension according to claim 1 or 2, characterized in that: The nonionic-anionic composite emulsifier at least includes fatty alcohol polyoxyethylene ether emulsifier and alkylbenzene sulfonate emulsifier.

4. The pyriproxyfen-buprofezin dispersible oil suspension according to claim 3, characterized in that: The HLB value of the fatty alcohol polyoxyethylene ether emulsifier is 10-15.

5. A pyriproxyfen-buprofezin dispersible oil suspension according to claim 4, characterized in that: The mass ratio of the fatty alcohol polyoxyethylene ether emulsifier to the alkylbenzene sulfonate emulsifier is (1-2):(3-5).

6. The pyriproxyfen-buprofezin dispersible oil suspension according to claim 5, characterized in that: The dispersant is selected from at least one of alkylphenol polyoxyethylene ether, benzylphenol polyoxyethylene ether and phenethylphenol polyoxyethylene ether.

7. A pyriproxyfen-buprofezin dispersible oil suspension according to claim 6, characterized in that: The stabilizer is selected from at least one of organic bentonite, white carbon black, kaolin, magnesium aluminum silicate, carboxymethyl cellulose, light calcium powder and talc.

8. The pyriproxyfen-buprofezin dispersible oil suspension according to claim 7, characterized in that: The mass ratio of the nonionic-anionic composite emulsifier, dispersant and stabilizer is (5-7): (5-7):

1.

9. The pyriproxyfen-buprofezin dispersible oil suspension according to claim 8, characterized in that: The dispersion medium is selected from one of methyl oleate, soybean oil, corn oil, solvent oil, paraffin oil, mineral oil and biodiesel.

10. A method for preparing the pyriproxyfen-buprofezin dispersible oil suspension according to any one of claims 1 to 9, characterized in that: The method comprises at least the following steps: stirring pyriproxyfen technical, thiazide technical, nonionic-anionic composite emulsifier, dispersant, stabilizer and dispersion medium into a slurry, and sand-milling the slurry for 1-1.5 hours using a sand mill to obtain the slurry.

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