Radiotherapy X-ray dose compensator and preparation method thereof

Abstract

The invention discloses a radiation therapy X-ray dose compensator and a preparation method thereof. The radiation therapy X-ray dose compensator comprises a hydrogel layer, strip-shaped hydrophilic areas and hydrophobic areas which are equal in width and are alternately arranged are arranged on the two surfaces of the hydrogel layer, the hydrophilic areas on one surface correspond to the hydrophobic areas on the other surface in position, and bionic structures are processed on the hydrophilic areas through femtosecond laser processing. The body surface fitness can be enhanced, air gaps are reduced, and the consistency of repeated treatment restoration is easy to guarantee.

Description

Technical Field

[0001] The invention belongs to the technical field of radiotherapy auxiliary, and in particular relates to a radiotherapy X-ray dose compensator and a preparation method thereof. Background Art

[0002] In tumor radiotherapy, a dose-building effect will occur when electron beams and photon beams enter the human body, resulting in low-dose areas in the superficial region. In order to increase the irradiation dose of the superficial treatment target area and reduce the total irradiation dose received by the patient, clinicians often use tissue compensators to increase the tissue thickness of the patient's irradiated area when formulating radiotherapy plans for shallow tumors, thereby adjusting the radiation dose distribution and increasing the skin and subcutaneous doses. This allows radiation physicists to better limit the OAR irradiation dose and push the target area when making radiotherapy plans, thereby improving the prognosis of radiotherapy.

[0003] Currently commonly used tissue compensators include silicone and polystyrene. The material density is close to that of human tissues and organs, and can simulate the interaction between human tissues and radiation. The relatively soft material properties enable it to fit well to the human body surface. It is usually made into sheets for the treatment of parts or organs with small contour fluctuations, such as the breast. For organs with large contour fluctuations, commonly used tissue compensators include low-temperature thermoplastic plates, paraffin, vaseline liquid, 3D printed tissue compensators, etc.

[0004] However, there is a problem with the existing compensating materials, that is, the degree of fit between the compensating materials and the skin is not high, and the repositioning property is difficult to ensure during multiple treatments. Summary of the invention

[0005] In order to solve the problem that existing compensators have poor skin adhesion and are difficult to ensure repositioning during multiple treatments, the present invention proposes a radiotherapy X-ray dose compensator and a preparation method thereof, which can enhance and improve the fit to the body surface, reduce air gaps, and ensure consistency of repositioning during multiple treatments.

[0006] The objective of the present invention is achieved through the following technical solutions: A first aspect of the present invention discloses a radiotherapy X-ray dose compensator, comprising a hydrogel layer; The hydrogel layer has strip-shaped hydrophilic regions and hydrophobic regions of equal width and arranged alternately on both sides, wherein the hydrophilic region on one side corresponds to the hydrophobic region on the other side, and the hydrophilic region is processed with a bionic structure by femtosecond laser treatment.

[0007] The second aspect of the present invention discloses a method for preparing a radiotherapy X-ray dose compensator, comprising the following steps: preparing a hydrogel layer; Performing hydrophobic modification on the hydrophobic regions on both sides of the hydrogel layer; The hydrophilic areas on both sides of the hydrogel layer are processed by femtosecond laser to form a bionic structure, so as to obtain a radiotherapy X-ray dose compensator as described in the first aspect.

[0008] The beneficial effects of the present invention are: 1. The present invention uses hydrogel as the base of the compensator, and sets a hydrophilic area and a hydrophobic area on both sides. The hydrophilic area is treated with a femtosecond laser, and has good skin adhesion. It does not require the aid of other fixed structures and can adhere closely to the skin, which can greatly reduce the air gap.

[0009] 2. The hydrophilic region on one side of the hydrogel of the present invention corresponds to the hydrophobic region on the other side, which facilitates the adjustment of the thickness of the compensation material according to specific circumstances.

[0010] 3. The present invention uses hydrogel as the base of the compensator, which can be used multiple times to improve the consistency of repositioning during multiple treatments.

[0011] 4. The present invention arranges hydrophilic regions and hydrophobic regions on the hydrogel, which can improve the user experience of the patient. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0013] Figure 1 It is a schematic diagram of the structure of the radiotherapy X-ray dose compensator of the present invention. DETAILED DESCRIPTION

[0014] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0015] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0016] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features of the embodiments may be combined with each other.

[0017] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0018] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or the positions or positional relationships in which the product of the invention is usually placed when in use, or the positions or positional relationships commonly understood by those skilled in the art, which are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0019] In the description of the present invention, it is also necessary to explain that, unless otherwise clearly specified and limited, the terms "set", "install", "connect", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0020] The first aspect of the present invention discloses a radiotherapy X-ray dose compensator, comprising a hydrogel layer; Figure 1 As shown, both sides of the hydrogel layer are provided with strip-shaped hydrophilic regions 1 and hydrophobic regions 2 of equal width and arranged alternately, wherein the hydrophilic region on one side corresponds to the position of the hydrophobic region on the other side, and the hydrophilic region is processed with a bionic structure by femtosecond laser treatment.

[0021] The shape of the hydrogel layer can be circular, square, oval or other irregular shapes.

[0022] In order to facilitate adjustment according to the thickness of the compensating material, the thickness of the hydrogel layer is 2 mm to 20 mm. Since the compensating material is provided with a hydrophilic region 1 and a hydrophobic region 2 on both sides, when stacked, the hydrophilic region 1 of one layer contacts the hydrophobic region 2 of another layer. Since the hydrophilic region 1 has extremely strong adhesion, stacking multiple layers does not affect normal use.

[0023] In order to further enhance the skin adhesion, the bionic structure is the toe plate of the gecko. The toe plates of the gecko are arranged in reverse, that is, there is a layer of molecular force between the dense toe plates. This arrangement allows the gecko to further enhance its adhesion ability with the help of the adsorption force between air molecules.

[0024] The hydrophilic region and the hydrophobic region are in strip shape and have the same width, and the width thereof is not too wide. Preferably, the width of the hydrophilic region is 2 mm to 5 mm.

[0025] Based on the above compensating material, the second aspect of the present invention discloses a method for preparing a radiotherapy X-ray dose compensating material, which comprises steps S1 to S3.

[0026] Step S1, preparing a hydrogel layer.

[0027] Specifically, the hydrogel layer can be implemented in various forms.

[0028] The hydrogel layer is obtained by cross-linking and polymerizing a functional monomer containing a carbon-carbon double bond and a tertiary amine group with an olefinic monomer.

[0029] In order to further enhance skin affinity, the hydrogel layer is obtained by cross-linking and polymerizing a functional monomer containing a carbon-carbon double bond and a tertiary amine group with an olefinic monomer. The functional monomer is one or more compounds containing a carbon-carbon double bond and a tertiary amine group.

[0030] For example, the functional monomer containing a carbon-carbon double bond and a tertiary amine group may be diethylaminoethyl methacrylate or 4-N,N-dimethylaminobenzyl methacrylate.

[0031] The olefin-containing monomer may be acrylonitrile or acrylic acid.

[0032] By using this hydrogel layer, no additional cross-linking agent needs to be added during the copolymerization process, and a cross-linked copolymer hydrogel can be generated at a lower temperature and in a shorter time, so that it has excellent mechanical properties and adhesion strength.

[0033] Step S2, performing hydrophobic modification on the hydrophobic regions on both sides of the hydrogel layer.

[0034] Step S3: The hydrophilic regions on both sides of the hydrogel layer are processed by femtosecond laser to form a bionic structure, so as to obtain a radiotherapy X-ray dose compensator as described in the first aspect.

[0035] This product is suitable for patients with superficial tumors who need 6MV X-ray external beam radiotherapy. It is suitable for tumors in various parts of the body, such as the head, neck, chest, abdomen, back, perineum, buttocks, limbs, etc., to help increase the X-ray dose of the surface and subcutaneous irradiation sites. For tumors located in superficial parts, the dose of the tumor target area is low due to the influence of the high-energy ray building effect. Covering the surface of the radiotherapy site with the product and making it fit, it can compensate for the building effect and increase the absorbed dose of superficial tumors. The compensator prepared by this method has an upper limit of 50 irradiation times, and the cumulative absorbed dose shall not exceed 100Gy.

[0036] Those skilled in the art will appreciate that the embodiments described herein are intended to help readers understand the principles of the present invention, and should be understood that the protection scope of the present invention is not limited to such specific statements and embodiments. Those skilled in the art can make various other specific variations and combinations that do not deviate from the essence of the present invention based on the technical revelations disclosed by the present invention, and these variations and combinations are still within the protection scope of the present invention.

Claims

1. A radiotherapy X-ray dose compensator, characterized in that: including a hydrogel layer; The hydrogel layer has strip-shaped hydrophilic regions and hydrophobic regions of equal width and arranged alternately on both sides, wherein the hydrophilic region on one side corresponds to the hydrophobic region on the other side, and the hydrophilic region is processed with a bionic structure by femtosecond laser treatment.

2. The radiotherapy X-ray dose compensator according to claim 1, characterized in that: The thickness of the hydrogel layer is 2 mm to 20 mm.

3. The radiotherapy X-ray dose compensator according to claim 1, characterized in that: The bionic structure is a gecko's toe plate.

4. The radiotherapy X-ray dose compensator according to claim 1, characterized in that: The width of the hydrophilic region is 2 mm to 5 mm.

5. A method for preparing a radiotherapy X-ray dose compensator, characterized in that: The following steps are involved: preparing a hydrogel layer; Performing hydrophobic modification on the hydrophobic regions on both sides of the hydrogel layer; The hydrophilic areas on both sides of the hydrogel layer are processed by femtosecond laser to form a bionic structure, so as to obtain a radiotherapy X-ray dose compensator as claimed in any one of claims 1 to 3.

6. The method for preparing a radiotherapy X-ray dose compensator according to claim 5, characterized in that: The preparation of the hydrogel layer is as follows: The hydrogel layer is obtained by cross-linking and polymerizing a functional monomer containing a carbon-carbon double bond and a tertiary amine group with an olefinic monomer.

7. The method for preparing a radiotherapy X-ray dose compensator according to claim 6, characterized in that: The functional monomer is one or more compounds containing carbon-carbon double bonds and tertiary amine groups.

Images