Equipment and method for synthesizing halofuginone hydrobromide

Abstract

The invention belongs to the technical field of halofuginone hydrobromide synthesis, and particularly relates to halofuginone hydrobromide synthesis equipment and method.The halofuginone hydrobromide synthesis equipment comprises a mixing tank and a tank cover, the bottom end of the tank cover is placed at the top of the mixing tank, a discharging port is formed in the top of the mixing tank, and a feeding port is formed in the right side of the tank cover; the motor is fixedly installed at the top of the tank cover, and an output shaft of the motor penetrates through the tank cover and is rotationally connected with the tank cover. Raw materials such as halofuginone and hydrobromide are fully stirred and mixed through a simple structure, and the stirring efficiency and effect are improved; meanwhile, accurate temperature regulation and control can be achieved during mixing reaction of halofuginone, hydrobromide and other raw materials, stable mixing reaction between halofuginone, hydrobromide and other raw materials is guaranteed, rapid disassembly and assembly between the tank cover and the mixing tank are achieved, staff can conveniently clean the interior of the mixing tank in the follow-up process, staff can conveniently maintain the mixing tank, and the working efficiency is improved. The practicability is high.

Description

Technical Field

[0001] The invention relates to the technical field of synthesis of halofuginone hydrobromide, and in particular to equipment and a method for synthesizing halofuginone hydrobromide. Background Art

[0002] Chuanxiong ketone, also known as para-acetylphenylpropylene, is one of the main active ingredients extracted from the Chinese medicinal material Ligusticum chuanxiong. Chuanxiong ketone is a volatile organic compound with a chemical structure of phenylpropylene compounds. It has certain pharmacological effects and is widely used in traditional Chinese medicine, especially in the treatment of cardiovascular and cerebrovascular diseases and blood circulation. Hydrobromic acid salts are salts formed by the reaction of hydrobromic acid (HBr) with certain metals or organic groups. Hydrobromic acid (HBr) is a strong acid generated by the reaction of hydrogen and bromine, similar to hydrochloric acid (HCl) and hydrosulfuric acid (H2SO4). Hydrobromic acid salts usually refer to salts formed by the reaction of hydrobromic acid with metals or other chemicals, common ones include sodium hydrobromide (NaBr), potassium hydrobromide (KBr), etc.

[0003] The synthesis method of hawthorne ketone and hydrobromide mainly relies on the bromination of hydrobromide, combined with nucleophilic substitution and cyclization reactions in synthetic chemistry, to gradually construct the structure of hawthorne ketone.

[0004] In the prior art, when synthesizing halofuginone and hydrobromide, an appropriate solvent (such as alcohol, ether, chloroform, etc.) is usually used to dissolve the reactants. It is generally necessary to stir and control the reaction temperature, reaction time and other conditions to optimize the yield. However, the existing stirring equipment has poor stirring efficiency and effect. At the same time, raw materials such as halofuginone and hydrobromide are chemical substances. The stirring and mixing equipment needs to be cleaned inside after use. The existing stirring and mixing equipment is inconvenient to clean and is not convenient for personnel to perform subsequent maintenance. Therefore, the present application proposes an apparatus and method for synthesizing halofuginone hydrobromide to solve the above problems. Summary of the invention

[0005] Based on the technical problems that the stirring equipment existing in the background technology has poor stirring efficiency and effect, and raw materials such as halofuginone and hydrobromide are both chemical substances, the stirring and mixing equipment needs to be cleaned inside after use, and the existing stirring and mixing equipment is inconvenient to clean and inconvenient for personnel to perform subsequent maintenance, the present invention proposes a device and method for synthesizing halofuginone hydrobromide.

[0006] The present invention provides a device for synthesizing halofuginone hydrobromide, comprising a mixing tank and a tank cover, wherein the bottom end of the tank cover is placed on the top of the mixing tank, a discharge port is provided on the top of the mixing tank, and a feed port is provided on the right side of the tank cover. The device also comprises: A motor, wherein the motor is fixedly mounted on the top of the tank cover, and an output shaft of the motor passes through the tank cover and is rotatably connected to the tank cover, and a first gear is fixedly mounted on the output shaft of the motor; There are multiple heating plates, and the mixing tank is provided with multiple installation cavities inside, and the heating plates are fixedly installed in the corresponding installation cavities; A stirring assembly, the stirring assembly comprising: a first gear ring, a cross bar, a second gear ring, two stirring rods and two second gears, the first gear ring is fixedly mounted on the top of the cross bar, the bottom end of the first gear can be detached and inserted into the inside of the first gear ring, the outer side of the second gear ring is fixedly mounted on the inner wall of the mixing tank, the top ends of the two stirring rods are rotatably connected to the bottom of the cross bar, the second gears are fixedly sleeved on the corresponding stirring rods, and the two second gears are meshed with the second gear ring; Two racks are provided, and the two racks are respectively fixedly mounted on the left and right sides of the tank cover; A connection box, two of which are fixedly installed on the left and right sides of the mixing tank respectively; The card-mounted components are provided in two numbers, and the card-mounted components are arranged in the corresponding connection boxes, and the card-mounted components cooperate with the corresponding racks.

[0007] By means of the above structure, the first gear can be driven to rotate by starting the motor. At this time, the cross bar can be driven to rotate through the plug-in limit and meshing transmission between the first gear and the first gear ring. When the cross bar rotates, the two stirring rods and the two second gears can be driven to perform circular motion. When the two second gears perform circular motion, the meshing transmission between the second gear and the second gear ring can drive the two stirring rods to rotate. At this time, the circular motion and self-rotation operation of the two stirring rods can be realized. In this way, the sufficient stirring and mixing of raw materials such as fufuginone and hydrobromide can be improved, and the stirring efficiency and effect are improved, and the practicability is strong.

[0008] Preferably, an observation window is provided on the front side of the mixing tank, and the material of the observation window is tempered glass.

[0009] Furthermore, by providing an observation window, personnel can conveniently check the mixing reaction of halofuginone and raw materials such as hydrobromide.

[0010] Preferably, a display and a controller are fixedly mounted on the front side of the mixing tank, and both the display and the controller cooperate with a plurality of heating plates.

[0011] Furthermore, by providing a display, a person can conveniently check the heating temperature of raw materials such as halofuginone and hydrobromide by the heating plate, and by providing a controller, a person can conveniently control the operation of the motor and the heating plate.

[0012] Preferably, a scraper is fixedly mounted on the bottom end of the stirring rod, and the bottom of the scraper is in contact with the bottom inner wall of the mixing tank.

[0013] Furthermore, by providing a scraper, the bottom inner wall of the mixing tank can be scraped and cleaned to avoid material sedimentation and ensure the mixing reaction effect.

[0014] Preferably, an annular groove is formed at the top of the second gear ring, and two sliding shafts are fixedly mounted at the bottom of the crossbar, and the bottom ends of the two sliding shafts are slidably connected to the inside of the annular groove.

[0015] Furthermore, the movement stability of the cross bar and the stirring rod can be improved through the sliding limit cooperation between the sliding shaft and the annular groove.

[0016] Preferably, the clamping assembly includes a support shaft, a half-tooth gear, two torsion springs, a sliding rod, a clamping rod, a spring, a pushing rod, a pressing rod and a rotating rod. A plug hole is provided on the top of the connecting box, the bottom end of the rack passes through the plug hole and contacts the bottom inner wall of the connecting box, the front end and the rear end of the support shaft are rotatably connected to the top inner wall and the bottom inner wall of the connecting box respectively, the half-tooth gear is fixedly sleeved on the support shaft, the half-tooth gear and the rack can be disengaged, the two torsion springs are both sleeved on the support shaft, the ends of the two torsion springs that are away from each other are fixedly connected to the front inner wall and the rear inner wall of the connecting box respectively, and the two torsion springs are close to each other. One end of the spring is fixedly installed on the inner wall of one side of the connecting box, and the other end of the spring is fixedly installed on the other side of the sliding rod. The bottom end of the pushing rod is rotatably connected to the top of the clamping rod, the bottom end of the pressing rod passes through the top of the connecting box and is rotatably connected to the top of the pushing rod, and the bottom of the rotating rod is rotatably connected to the top of the pressing rod.

[0017] Furthermore, by moving the tank cover downward and plugging the rack into the interior of the connecting box through the jack, the rack can contact and mesh with the half-tooth gear. At this time, the downward movement of the rack can drive the half-tooth gear and the support shaft to rotate, and the torsion spring is twisted. Then, when the half-tooth gear rotates, the slot will correspond to the lever. At this time, the elastic reset characteristic of the spring can drive the sliding rod and the lever to move and reset, and then the lever will complete the clamping between the slot. At this time, the half-tooth gear can be clamped and fixed to prevent the half-tooth gear from rotating. At the same time, the rack and the connecting The tank cover can be stably installed between the boxes and can ensure the installation stability between the tank cover and the mixing tank. Here, by pressing down the rotating rod and the pressure rod, the push rod can be driven to rotate and the clamping rod can be driven to move. At this time, the clamping rod can be disengaged from the clamping slot, and the rotation limit of the half-tooth gear can be released. At this time, the tank cover can be moved up to pull the rack out of the connection box, thereby realizing the disassembly between the tank cover and the mixing tank. In this way, the tank cover and the mixing tank can be quickly disassembled and assembled, which is convenient for personnel to clean the inside of the mixing tank later and convenient for personnel to perform maintenance.

[0018] Preferably, the top inner wall and the bottom inner wall of the connection box are both provided with sliding grooves, and the top end and the bottom end of the sliding rod are respectively slidably connected in the two sliding grooves.

[0019] Furthermore, by providing the sliding groove, the sliding rod and the clamping rod can be stably slidingly limited and slidingly supported.

[0020] Preferably, a limit rod is fixedly installed on the top of the connection box, and the limit rod cooperates with the rotating rod.

[0021] Furthermore, by setting a limit cooperation between the limit rod and the rotating rod, the pressure rod and the push rod can be moved downward and the contact between the card rod and the card slot can be inserted to limit the upward movement, which is convenient for personnel to disassemble and assemble the rack and the tank cover.

[0022] The present invention also provides a method for using a device for synthesizing halofuginone hydrobromide, comprising the following steps: S1: First, connect the display, controller, motor and heating plate to external power; S2: adding halofuginone and hydrobromide synthesis raw materials into the mixing tank through the feed port; S3: Then, by starting the motor and through the transmission cooperation between the motor and the stirring rod, the circular motion and self-rotation operation of the two stirring rods can be realized; S4: finally, the halofuginone and hydrobromide synthesis raw materials after the mixed reaction are discharged and collected through the discharge port; S5: In addition, by setting the card-mounted assembly and the card-mounted limit cooperation between the rack and the connecting box, the tank cover and the mixing tank can be quickly disassembled and assembled, which is convenient for personnel to clean the inside of the mixing tank later and facilitate maintenance.

[0023] The beneficial effects of the present invention are: 1. The first gear can be driven to rotate by starting the motor. At this time, the cross bar can be driven to rotate by the plug-in limit and meshing transmission between the first gear and the first gear ring. When the cross bar rotates, the two stirring rods and the two second gears can be driven to perform annular motion. When the two second gears perform annular motion, the meshing transmission between the second gear and the second gear ring can drive the two stirring rods to rotate. At this time, the annular motion and self-rotation operation of the two stirring rods can be realized. In this way, the raw materials such as halofuginone and hydrobromide can be fully stirred and mixed, and the stirring efficiency and effect are improved, which is highly practical. 2. The quick disassembly and assembly between the tank cover and the mixing tank is realized by inserting and limiting the rack and the connection box and setting the card assembly, which is convenient for personnel to clean the inside of the mixing tank and perform maintenance; 3. By setting a display, it is convenient for personnel to check the heating temperature of raw materials such as halofuginone and hydrobromide by the heating plate, and by setting a controller, it is convenient for personnel to control the operation of the motor and the heating plate, so that accurate temperature control can be achieved during the mixing reaction of raw materials such as halofuginone and hydrobromide, thereby ensuring a stable mixing reaction between raw materials such as halofuginone and hydrobromide; The invention realizes sufficient stirring and mixing of raw materials such as halofuginone and hydrobromide through a simple structure, improves stirring efficiency and effect, and can simultaneously realize accurate temperature control during the mixing reaction of raw materials such as halofuginone and hydrobromide, thereby ensuring a stable mixing reaction between raw materials such as halofuginone and hydrobromide, and realizes rapid disassembly and assembly between the tank cover and the mixing tank, thereby facilitating subsequent cleaning of the interior of the mixing tank by personnel, facilitating maintenance by personnel, and having strong practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 A structural front view of a device for synthesizing halofuginone hydrobromide proposed by the present invention; Figure 2 A main cross-sectional view of the structure of a device for synthesizing halofuginone hydrobromide proposed by the present invention; Figure 3 The invention provides an attachment for a device for synthesizing halofuginone hydrobromide. Figure 2 Schematic diagram of the structure of part A; Figure 4 A main cross-sectional view of the structure of a connection box of a device for synthesizing halofuginone hydrobromide proposed by the present invention; Figure 5 The present invention provides a three-dimensional structural diagram of a supporting shaft, a half-tooth gear, a torsion spring and a slot for a device for synthesizing halofuginone hydrobromide.

[0025] In the figure: 1. mixing tank; 2. tank cover; 3. feed port; 4. discharge port; 5. observation window; 6. display; 7. controller; 8. motor; 9. first gear; 10. first gear ring; 11. cross bar; 12. second gear ring; 13. stirring rod; 14. second gear; 15. sliding shaft; 16. annular groove; 17. scraper; 18. heating plate; 19. rack; 20. connecting box; 21. jack; 22. support shaft; 23. half-tooth gear; 24. torsion spring; 25. slot; 26. sliding rod; 27. locking rod; 28. slide slot; 29. ​​spring; 30. push rod; 31. pressure rod; 32. rotating rod; 33. limit rod. DETAILED DESCRIPTION

[0026] The present invention will be further explained below in conjunction with specific embodiments.

[0027] refer to Figure 1-Figure 5 In this embodiment, a device for synthesizing halofuginone hydrobromide is proposed, comprising a mixing tank 1 and a tank cover 2, wherein the bottom end of the tank cover 2 is placed on the top of the mixing tank 1, a discharge port 4 is provided on the top of the mixing tank 1, and a feed port 3 is provided on the right side of the tank cover 2. The device also comprises: The motor 8 is fixedly mounted on the top of the tank cover 2, and the output shaft of the motor 8 passes through the tank cover 2 and is rotatably connected to the tank cover 2. A first gear 9 is fixedly mounted on the output shaft of the motor 8; There are multiple heating plates 18, and multiple installation cavities are provided inside the mixing tank 1. The heating plates 18 are fixedly installed in the corresponding installation cavities; A stirring assembly, the stirring assembly comprises: a first gear ring 10, a cross bar 11, a second gear ring 12, two stirring rods 13 and two second gears 14, the first gear ring 10 is fixedly mounted on the top of the cross bar 11, the bottom end of the first gear 9 can be detached and inserted into the inside of the first gear ring 10, the outer side of the second gear ring 12 is fixedly mounted on the inner wall of the mixing tank 1, the top ends of the two stirring rods 13 are rotatably connected to the bottom of the cross bar 11, the second gears 14 are fixedly sleeved on the corresponding stirring rods 13, and the two second gears 14 are meshed with the second gear ring 12; Racks 19, which are provided in two pieces, and the two racks 19 are respectively fixedly mounted on the left and right sides of the tank cover 2; A connection box 20, wherein two connection boxes 20 are respectively fixedly installed on the left and right sides of the mixing tank 1; There are two card-mounted components, which are arranged in the corresponding connection box 20 and matched with the corresponding rack 19 .

[0028] By means of the above structure, the first gear 9 can be driven to rotate by starting the motor 8. At this time, the cross bar 11 can be driven to rotate through the plug-in limit and meshing transmission between the first gear 9 and the first gear ring 10. When the cross bar 11 rotates, the two stirring rods 13 and the two second gears 14 can be driven to perform circular motion. When the two second gears 14 perform circular motion, the meshing transmission between the second gear 14 and the second gear ring 12 can drive the two stirring rods 13 to rotate. At this time, the circular motion and rotation operation of the two stirring rods 13 can be realized. In this way, the sufficient stirring and mixing of raw materials such as hawthorne and hydrobromide can be improved, and the stirring efficiency and effect are improved, and the practicability is strong.

[0029] In this embodiment, an observation window 5 is provided on the front side of the mixing tank 1. The material of the observation window 5 is tempered glass. By opening the observation window 5, personnel can conveniently check the mixing reaction of halofuginone and raw materials such as hydrobromide.

[0030] In this embodiment, a display 6 and a controller 7 are fixedly installed on the front side of the mixing tank 1. The display 6 and the controller 7 are both matched with multiple heating plates 18. By setting the display 6, it is convenient for personnel to check the heating temperature of raw materials such as fufurin and hydrobromide by the heating plates 18, and by setting the controller 7, it is convenient for personnel to control the operation of the motor 8 and the heating plates 18.

[0031] In this embodiment, a scraper 17 is fixedly installed at the bottom end of the stirring rod 13, and the bottom of the scraper 17 is in contact with the bottom inner wall of the mixing tank 1. By setting the scraper 17, the bottom inner wall of the mixing tank 1 can be scraped and cleaned to avoid material precipitation and ensure the mixing reaction effect.

[0032] In this embodiment, an annular groove 16 is opened at the top of the second gear ring 12, and two sliding shafts 15 are fixedly installed at the bottom of the cross bar 11. The bottom ends of the two sliding shafts 15 are slidably connected to the inside of the annular groove 16. Through the sliding limit cooperation between the sliding shafts 15 and the annular groove 16, the movement stability of the cross bar 11 and the stirring rod 13 can be improved.

[0033] In this embodiment, the clamping assembly includes a support shaft 22, a half-tooth gear 23, two torsion springs 24, a slide bar 26, a clamping bar 27, a spring 29, a push rod 30, a pressure rod 31 and a rotating rod 32. A plug hole 21 is provided on the top of the connection box 20. The bottom end of the rack 19 passes through the plug hole 21 and contacts the bottom inner wall of the connection box 20. The front and rear ends of the support shaft 22 are rotatably connected to the top inner wall and the bottom inner wall of the connection box 20 respectively. The half-tooth gear 23 is fixedly sleeved on the support shaft 22, and the half-tooth gear 23 can be disengaged from the rack 19. The two torsion springs 24 are both sleeved on the support shaft 22, and the ends of the two torsion springs 24 that are away from each other are fixedly sleeved on the front inner wall and the rear inner wall of the connection box 20 respectively. The ends of the two torsion springs 24 that are close to each other are fixedly installed with the front and rear sides of the half-tooth gear 23, respectively. A slot 25 is provided on the half-tooth gear 23. The top and bottom ends of the slide bar 26 are slidably connected with the top inner wall and the bottom inner wall of the connection box 20, respectively. One end of the card rod 27 is fixedly installed on one side of the slide bar 26, and the other end of the card rod 27 can be detached and inserted in the slot 25. One end of the spring 29 is fixedly installed on one side of the inner wall of the connection box 20, and the other end of the spring 29 is fixedly installed on the other side of the slide bar 26. The bottom end of the push rod 30 is rotatably connected to the top of the card rod 27, and the bottom end of the pressure rod 31 passes through the top of the connection box 20 and is rotatably connected to the top of the push rod 30. The rotating rod 3 2 is rotatably connected to the top of the pressure rod 31, and the can cover 2 is moved down and the rack 19 is plugged into the interior of the connection box 20 through the jack 21. At this time, the rack 19 can contact and mesh with the half-tooth gear 23. At this time, the downward movement of the rack 19 can drive the half-tooth gear 23 and the support shaft 22 to rotate, and the torsion spring 24 is twisted. Then, when the half-tooth gear 23 rotates, the slot 25 will correspond to the lever 27. At this time, the elastic reset characteristic of the spring 29 can drive the slide bar 26 and the lever 27 to move and reset, and then the lever 27 will complete the clamping between the slot 25. At this time, the clamping fixation of the half-tooth gear 23 can be realized to prevent the half-tooth gear 23 from rotating. At the same time, it can achieve stable installation between the rack 19 and the connecting box 20, and can ensure the installation stability between the tank cover 2 and the mixing tank 1. Here, by pressing down the rotating rod 32 and the pressure rod 31, the push rod 30 can be driven to rotate and the clamping rod 27 can be driven to move. At this time, the clamping rod 27 can be disengaged from the clamping between the clamping slot 25, and the rotation limit of the half-tooth gear 23 can be released. At this time, the upward tank cover 2 can pull the rack 19 out of the connecting box 20, thereby realizing the disassembly between the tank cover 2 and the mixing tank 1. In this way, the tank cover 2 and the mixing tank 1 can be quickly disassembled and assembled, which is convenient for personnel to clean the interior of the mixing tank 1 later and convenient for personnel to perform maintenance.

[0034] In this embodiment, the top inner wall and the bottom inner wall of the connecting box 20 are both provided with sliding grooves 28, and the top and bottom ends of the sliding rod 26 are respectively slidably connected in the two sliding grooves 28. By providing the sliding grooves 28, the sliding rod 26 and the clamping rod 27 can be stably slidably limited and slidably supported.

[0035] In this embodiment, a limit rod 33 is fixedly installed on the top of the connecting box 20, and the limit rod 33 cooperates with the rotating rod 32. By setting the limit cooperation between the limit rod 33 and the rotating rod 32, the pressure rod 31 and the push rod 30 can be moved downward and the contact between the card rod 27 and the card slot 25 can be limited upward, which is convenient for personnel to disassemble and assemble the rack 19 and the tank cover 2.

[0036] The present invention also provides a method for using a device for synthesizing halofuginone hydrobromide, comprising the following steps: S1: First, the display 6, the controller 7, the motor 8 and the heating plate 18 are connected to an external power supply; S2: adding halofuginone and hydrobromide synthesis raw materials into the mixing tank 1 through the feed port 3; S3: Then, by starting the motor 8 and through the transmission cooperation between the motor 8 and the stirring rod 13, the circular motion and self-rotation operation of the two stirring rods 13 can be realized; S4: finally, the halofuginone and hydrobromide synthesis raw materials after the mixed reaction are discharged and collected through the discharge port 4; S5: In addition, by setting the card assembly and the card limit cooperation between the rack 19 and the connecting box 20, the tank cover 2 and the mixing tank 1 can be quickly disassembled and assembled, which is convenient for personnel to clean the interior of the mixing tank 1 and perform maintenance.

[0037] It should be noted that the specific types of display 6, controller 7, motor 8 and heating plate 18 to be used are selected by relevant technical personnel familiar with the field, and the above display 6, controller 7, motor 8 and heating plate 18 are all existing technologies and will not be elaborated in this solution.

[0038] Working principle: When in use, first connect the display 6, controller 7, motor 8 and heating plate 18 to the external power supply, then move the tank cover 2 downward and plug the rack 19 into the interior of the connection box 20 through the jack 21, then the rack 19 can contact and mesh with the semi-toothed gear 23, at this time, the downward movement of the rack 19 can drive the semi-toothed gear 23 and the support shaft 22 to rotate, and the torsion spring 24 is twisted, and then when the semi-toothed gear 23 rotates, the card slot 25 will correspond to the card rod 27, and the elastic reset characteristic of the spring 29 can drive the slide bar 26 and the card rod 27 to move and reset, and then the card rod 27 will The clamping groove 25 is completed, and the clamping and fixing of the half-tooth gear 23 can be achieved to prevent the half-tooth gear 23 from rotating. At the same time, the stable installation between the rack 19 and the connecting box 20 can be achieved, and the installation stability between the tank cover 2 and the mixing tank 1 can be guaranteed. Here, by pressing down the rotating rod 32 and the pressing rod 31, the pushing rod 30 can be driven to rotate and the clamping rod 27 can be driven to move. At this time, the clamping rod 27 can be separated from the clamping groove 25. At this time, the rotation limit of the half-tooth gear 23 can be released. At this time, the tank cover 2 can be moved up to pull the rack 19 out of the connecting box 20, so that the tank cover 2 and the mixing tank 1 can be fixed. In this way, the tank cover 2 and the mixing tank 1 can be quickly disassembled and assembled, which is convenient for personnel to clean the interior of the mixing tank 1 later and convenient for personnel to perform maintenance. In addition, the first gear 9 can be driven to rotate by starting the motor 8. At this time, the cross bar 11 can be driven to rotate through the plug-in limit and meshing transmission between the first gear 9 and the first gear ring 10. When the cross bar 11 rotates, it can drive the two stirring rods 13 and the two second gears 14 to perform circular motion. When the two second gears 14 perform circular motion, the two stirring rods 13 can be driven through the meshing transmission between the second gear 14 and the second gear ring 12. The two stirring rods 13 can rotate by themselves, and the circular motion and rotation operation of the two stirring rods 13 can be realized at this time. In this way, the sufficient stirring and mixing of raw materials such as halofuginone and hydrobromide can be improved, and the stirring efficiency and effect are improved, and the practicability is strong. Finally, by setting the display 6, it is convenient for personnel to check the heating temperature of the raw materials such as halofuginone and hydrobromide by the heating plate 18, and by setting the controller 7, it is convenient for personnel to control the operation of the motor 8 and the heating plate 18, and accurate temperature control can be achieved during the mixing reaction of raw materials such as halofuginone and hydrobromide, so as to ensure the stable mixing reaction between raw materials such as halofuginone and hydrobromide, and the practicability is strong.

[0039] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A device for synthesizing halofuginone hydrobromide, comprising a mixing tank (1) and a tank cover (2), wherein the bottom end of the tank cover (2) is placed on the top of the mixing tank (1), a discharge port (4) is provided on the top of the mixing tank (1), and a feed port (3) is provided on the right side of the tank cover (2), characterized in that: The device also includes: a motor (8), wherein the motor (8) is fixedly mounted on the top of the tank cover (2), and an output shaft of the motor (8) passes through the tank cover (2) and is rotatably connected to the tank cover (2), and a first gear (9) is fixedly mounted on the output shaft of the motor (8); The heating plates (18) are provided in plurality, a plurality of installation cavities are provided inside the mixing tank (1), and the heating plates (18) are fixedly installed in corresponding installation cavities; A stirring assembly, the stirring assembly comprising: a first gear ring (10), a cross bar (11), a second gear ring (12), two stirring rods (13) and two second gears (14), wherein the first gear ring (10) is fixedly mounted on the top of the cross bar (11), the bottom end of the first gear (9) can be detachably inserted into the interior of the first gear ring (10), the outer side of the second gear ring (12) is fixedly mounted on the inner wall of the mixing tank (1), the top ends of the two stirring rods (13) are both rotatably connected to the bottom of the cross bar (11), the second gears (14) are fixedly sleeved on the corresponding stirring rods (13), and the two second gears (14) are both meshed with the second gear ring (12); Racks (19), which are provided in two numbers, and the two racks (19) are respectively fixedly mounted on the left side and the right side of the tank cover (2); A connection box (20), wherein two connection boxes (20) are respectively fixedly mounted on the left and right sides of the mixing tank (1); The card assembly is provided in two pieces, the card assembly is provided in a corresponding connection box (20), and the card assembly cooperates with a corresponding rack (19).

2. The device for synthesizing halofuginone hydrobromide according to claim 1, characterized in that: An observation window (5) is provided on the front side of the mixing tank (1), and the material of the observation window (5) is tempered glass.

3. The device for synthesizing halofuginone hydrobromide according to claim 1, characterized in that: A display (6) and a controller (7) are fixedly mounted on the front side of the mixing tank (1), and both the display (6) and the controller (7) are matched with a plurality of heating plates (18).

4. The device for synthesizing halofuginone hydrobromide according to claim 1, characterized in that: A scraper (17) is fixedly mounted on the bottom end of the stirring rod (13), and the bottom of the scraper (17) is in contact with the bottom inner wall of the mixing tank (1).

5. The device for synthesizing halofuginone hydrobromide according to claim 1, characterized in that: An annular groove (16) is formed at the top of the second gear ring (12), and two sliding shafts (15) are fixedly mounted at the bottom of the crossbar (11), with the bottom ends of the two sliding shafts (15) being slidably connected inside the annular groove (16).

6. The device for synthesizing halofuginone hydrobromide according to claim 1, characterized in that: The clamping assembly comprises a support shaft (22), a half-tooth gear (23), two torsion springs (24), a slide bar (26), a clamping bar (27), a spring (29), a push rod (30), a pressure rod (31) and a rotating rod (32). A plug hole (21) is provided at the top of the connection box (20). The bottom end of the rack (19) passes through the plug hole (21) and contacts the bottom inner wall of the connection box (20). The front end and the rear end of the support shaft (22) are rotatably connected to the top inner wall and the bottom inner wall of the connection box (20) respectively. The half-tooth gear (23) is fixedly sleeved on the support shaft (22). The half-tooth gear (23) and the rack (19) can be disengaged from each other. The two torsion springs (24) are sleeved on the support shaft (22). The ends of the two torsion springs (24) that are away from each other are fixedly connected to the front inner wall and the rear inner wall of the connection box (20) respectively. The ends of the half-toothed gear (24) and the half-toothed gear (23) are fixedly mounted on the front and rear sides thereof, respectively. A slot (25) is provided on the half-toothed gear (23). The top and bottom ends of the slide bar (26) are slidably connected to the top inner wall and the bottom inner wall of the connection box (20), respectively. One end of the card rod (27) is fixedly mounted on one side of the slide bar (26), and the other end of the card rod (27) can be detached and inserted into the slot (25). One end of the spring (29) is fixedly mounted on one inner wall of the connection box (20), and the other end of the spring (29) is fixedly mounted on the other side of the slide bar (26). The bottom end of the push rod (30) is rotatably connected to the top of the card rod (27). The bottom end of the pressure rod (31) passes through the top of the connection box (20) and is rotatably connected to the top of the push rod (30). The bottom end of the rotating rod (32) is rotatably connected to the top of the pressure rod (31).

7. The device for synthesizing halofuginone hydrobromide according to claim 6, characterized in that: The top inner wall and the bottom inner wall of the connection box (20) are both provided with sliding grooves (28), and the top end and the bottom end of the sliding rod (26) are respectively slidably connected in the two sliding grooves (28).

8. The device for synthesizing halofuginone hydrobromide according to claim 6, characterized in that: A limit rod (33) is fixedly mounted on the top of the connection box (20), and the limit rod (33) cooperates with the rotating rod (32).

9. A method for using a device for synthesizing halofuginone hydrobromide, characterized in that: The following steps are involved: S1: firstly, the display (6), the controller (7), the motor (8) and the heating plate (18) are connected to an external power source; S2: adding halofuginone and hydrobromide synthesis raw materials into the mixing tank (1) through the feed inlet (3); S3: Then, by starting the motor (8) and through the transmission cooperation between the motor (8) and the stirring rod (13), the circular motion and self-rotation operation of the two stirring rods (13) can be realized; S4: Finally, the halofuginone and hydrobromide synthesis raw materials after the mixed reaction are discharged and collected through the discharge port (4); S5: In addition, by providing a clamping limiter cooperation between the clamping assembly and the rack (19) and the connecting box (20), it is possible to achieve rapid disassembly and assembly between the tank cover (2) and the mixing tank (1), thereby facilitating subsequent cleaning of the interior of the mixing tank (1) and maintenance by personnel.

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