Testing device of artificial heart pump

Abstract

The invention relates to the technical field of artificial heart pumps, and discloses a testing device of an artificial heart pump. The testing device of the artificial heart pump comprises a simulated left atrial cavity, a simulated mitral valve, a simulated left ventricular cavity, a simulated aortic valve, a simulated aortic cavity and a simulated vein cavity which are used for forming a blood circulation flowing system, so that the blood circulation process in a human body can be simply and accurately reproduced; therefore, the hemodynamic characteristics of the natural heart of the human body at different failure degrees and in different physiological states can be simulated, and the auxiliary blood pumping effect of the artificial heart pump at different failure degrees in the simulated left ventricular cavity and the simulated left atrial cavity and in different physiological states can be tested. And a hydraulic performance experiment and an in-vitro blood circulation experiment of the artificial heart pump can be carried out based on the testing device, so that the accuracy of a testing result of the artificial heart pump and the integrity of testing performance are ensured.

Description

Technical Field

[0001] The invention relates to the technical field of artificial heart pumps, in particular to a testing device for artificial heart pumps. Background Art

[0002] Heart failure is a common problem faced by the world today. In addition to heart transplantation, artificial heart pumps have become a hope and effective treatment for many patients to prolong their survival. In the development of artificial heart pumps, a series of processes are required, including theoretical design, simulation verification, experimental testing, animal experiments and clinical trials, among which experimental testing is a key link.

[0003] At present, simulation technology is usually used to simulate the hemodynamic characteristics of the human body's natural heart at different degrees of failure and under different physiological conditions, so as to simulate and test the auxiliary pumping effect of the artificial heart pump when the natural heart has different degrees of failure and under different physiological conditions.

[0004] However, since the actual working environment of the natural heart and artificial heart pump in the human body is quite complex and is easily affected by unexpected situations and external interference, the accuracy and reliability of the test results of the artificial heart pump tested by simulation cannot be guaranteed.

[0005] Therefore, there is an urgent need for a testing device for an artificial heart pump that can solve the above problems. Summary of the invention

[0006] One purpose of the present invention is to provide a testing device for an artificial heart pump, which can accurately simulate the actual working environment of a natural heart and an artificial heart pump in the human body, so as to accurately test the auxiliary pumping effect of the artificial heart pump when the natural heart has different degrees of failure and under different physiological conditions, thereby ensuring that the test results of the artificial heart pump are highly accurate and reliable.

[0007] To achieve this object, the present invention adopts the following technical solutions:

[0008] A test device for an artificial heart pump comprises a test bench and the following components respectively arranged on the test bench:

[0009] A simulated left ventricular cavity is used to pump blood to a simulated aorta and can adjust the blood flow rate;

[0010] A simulated left atrial cavity connected to the inlet of the simulated left ventricular cavity, the simulated left atrial cavity is used to return blood to the simulated left ventricular cavity and can adjust the blood flow volume pumped out;

[0011] A simulated mitral valve, connected between the simulated left ventricular cavity and the simulated left atrial cavity, the simulated mitral valve is used to limit the simulated blood pumped out of the simulated left atrial cavity to flow unidirectionally to the simulated left ventricular cavity;

[0012] A simulated aortic valve is connected to the outlet of the simulated left ventricular cavity, the simulated aortic valve is used to limit the simulated blood pumped out of the simulated left ventricular cavity to flow unidirectionally to the simulated aorta, and an artificial heart pump is connected between the outlet of the simulated left ventricular cavity and the outlet of the simulated aortic valve, and the artificial heart pump can pump simulated blood from the simulated left ventricular cavity to the simulated aorta;

[0013] A simulated aortic cavity connected to the outlet of the simulated aortic valve, wherein the simulated aortic cavity can simulate the compliance of the aorta;

[0014] The simulated venous cavity has one end connected to the outlet of the simulated aorta cavity and the other end connected to the inlet of the simulated left atrium cavity. The simulated venous cavity can simulate a vein to store blood.

[0015] As an optional solution, a manual ball valve is connected between the artificial heart pump and the simulated left ventricular cavity, and the manual ball valve is used to control the connection or blocking between the artificial heart pump and the simulated left ventricular cavity.

[0016] As an optional solution, the structure of the simulated left atrial cavity is the same as the structure of the simulated left ventricular cavity; the simulated left ventricular cavity includes:

[0017] Drive motor;

[0018] A first hollow cylinder is connected to the test bench, wherein simulated blood is arranged in the first hollow cylinder, and a first piston is sealed and slidably arranged in the first hollow cylinder, wherein the output shaft of the drive motor is used to connect with the first piston to drive the first piston to slide back and forth along the height direction of the first hollow cylinder, so that the first piston squeezes the simulated blood downward and pumps it out along the outlet of the first hollow cylinder to the simulated aorta, and when the first piston moves upward and resets, the simulated blood flows into the first hollow cylinder from the simulated left atrium cavity.

[0019] As an optional solution, the simulated left ventricular cavity further includes:

[0020] A slide, the output shaft of the driving motor is connected to the slide, and is used to drive the slide to slide back and forth along the height direction of the first hollow cylinder;

[0021] A sliding rod has one end connected to the sliding platform, and the other end slides downward and is sealedly inserted into the first hollow cylinder and connected to the first piston.

[0022] As an optional solution, the structure of the simulated mitral valve is the same as the structure of the simulated aortic valve; the simulated aortic valve comprises:

[0023] A first acrylic flange and a second acrylic flange are arranged opposite to each other, wherein the first acrylic flange is connected to the outlet of the simulated left ventricular cavity, and the second acrylic flange is respectively connected to the inlet of the simulated aortic cavity and the outlet of the artificial heart pump;

[0024] The silicone gasket is connected between the first acrylic flange and the second acrylic flange, and the simulated blood is limited to flow through the first acrylic flange and the silicone gasket in a unidirectional manner to the second acrylic flange.

[0025] As an optional solution, the simulated aorta cavity comprises:

[0026] A second hollow cylinder connected to the test bench, wherein simulated blood is arranged in the second hollow cylinder;

[0027] An air pressure regulating valve is disposed at the top of the second hollow cylinder, and the air pressure regulating valve is used to adjust the air volume in the second hollow cylinder, and the air volume in the second hollow cylinder is linearly related to the compliance of the simulated aorta;

[0028] A laser rangefinder is arranged at the top of the second hollow cylinder, and is used to detect the liquid level of the simulated blood in the second hollow cylinder. The air volume in the second hollow cylinder corresponds to the liquid level of the simulated blood in the second hollow cylinder.

[0029] As an optional solution, the simulated venous cavity comprises:

[0030] The third hollow cylinder is connected to the test bench, and is used to store simulated blood.

[0031] As an optional solution, the test device of the artificial heart pump further includes:

[0032] The ultrasonic blood flow meter is connected between the simulated aorta cavity and the simulated vein cavity, and is used to detect the blood flow in the simulated vein.

[0033] As an optional solution, the test device of the artificial heart pump further includes:

[0034] An electric proportional valve is connected between the simulated aorta cavity and the ultrasonic blood flow meter. The electric proportional valve is used to adjust the percentage of opening of its valve port to simulate the change of flow resistance of circulating blood.

[0035] As an optional solution, the test device of the artificial heart pump further includes:

[0036] A control module, respectively connected to the drive motor and the electric proportional valve;

[0037] The pressure sensor is used to measure blood pressure information. The simulated left ventricular cavity, the simulated aorta and the simulated vein are respectively equipped with the pressure sensors.

[0038] The beneficial effects of the present invention are:

[0039] A simulated left ventricular cavity, a simulated left atrial cavity, a simulated mitral valve, a simulated aortic valve, a simulated aortic cavity and a simulated venous cavity are formed by mechanical structure production, so that simulated blood can circulate in the simulated left atrial cavity, the simulated mitral valve, the simulated left ventricular cavity, the simulated aortic valve, the simulated aortic cavity, the simulated venous cavity and the simulated left atrial cavity in sequence, thereby simulating each key organ in the human blood circulation by designing a mechanical structure, thereby being able to more accurately reproduce the blood circulation process of the human body's natural heart; at the same time, an artificial heart pump is connected between the outlet of the simulated left ventricular cavity and the outlet of the simulated aortic valve, so that the artificial heart pump can pump simulated blood from the simulated left ventricular cavity to the simulated aorta; and, it is capable of adjusting the blood flow volume pumped out by the simulated left ventricular cavity and the simulated left atrial cavity according to the changes of the natural heart in different degrees of failure and in different physiological states, so as to accurately simulate the actual working environment of the natural heart and the artificial heart pump in the human body, so as to accurately simulate the hemodynamic characteristics of the natural heart in different degrees of failure and in different physiological states, so as to accurately test the auxiliary pumping effect of the artificial heart pump in the natural heart with different degrees of failure and in different physiological states, and reversely verify the test results of the artificial heart pump obtained through simulation according to the test results, thereby ensuring that the test results of the artificial heart pump are highly accurate and reliable. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 It is a structural schematic diagram of the test device of the artificial heart pump provided by the present invention.

[0041] Reference numerals:

[0042] 10-simulated left ventricular cavity; 101-driving motor; 102-first hollow cylinder; 103-first piston; 104-sliding rod; 105-simulated blood;

[0043] 2-simulated left atrium cavity; 3-simulated mitral valve; 4-simulated aortic valve; 5-simulated aortic cavity; 51-second hollow cylinder; 52-air pressure regulating valve; 53-laser rangefinder; 6-simulated venous cavity; 7-manual ball valve; 8-check valve; 9-electric proportional valve; 11-artificial heart pump; 12-pressure sensor; 13-simulated aorta; 14-simulated vein; 15-ultrasonic blood flow meter;

[0044] 161-industrial computer; 162-data acquisition card. DETAILED DESCRIPTION

[0045] In order to make the technical problem solved by the present invention, the technical solution adopted and the technical effect achieved more clearly, the technical solution of the present invention is further explained below with reference to the accompanying drawings and through specific implementation methods.

[0046] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0047] In the present invention, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0048] In the description of this embodiment, the terms "upper", "lower", "left", "right" and other directions or positional relationships are based on the directions or positional relationships shown in the drawings, and are only for the convenience of description and simplification of operation, rather than indicating or implying that the structure or element referred to must have a specific direction, be constructed and operate in a specific direction, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0049] In the present embodiment, a test device for an artificial heart pump is proposed for testing the auxiliary pumping effect of the artificial heart pump. The test device for the artificial heart pump can accurately simulate the actual working environment of the natural heart and the artificial heart pump in the human body, so as to accurately test the auxiliary pumping effect of the artificial heart pump when the natural heart has different degrees of failure and under different physiological conditions, and can reversely verify the test results of the artificial heart pump obtained through simulation, thereby ensuring that the test results of the artificial heart pump are highly accurate and reliable.

[0050] Specifically, if Figure 1 As shown, the test device of the artificial heart pump includes a test bench and a simulated left ventricular cavity 10, a simulated left atrial cavity 2, a simulated mitral valve 3, a simulated aortic valve 4, a simulated aortic cavity 5 and a simulated venous cavity 6 respectively arranged on the test bench; wherein the simulated left ventricular cavity 10 can simulate the beating and pumping of the natural left ventricular cavity of the human body, and the simulated left ventricular cavity 10 is used to pump blood to the simulated aorta 13 and can adjust the blood flow volume thereof; the simulated left atrial cavity 2 can simulate the beating and pumping of the natural left atrial cavity of the human body, and the simulated left atrial cavity 2 is connected to the inlet of the simulated left ventricular cavity 10, and the simulated left atrial cavity 2 is used to return blood to the simulated left ventricular cavity 10 and can adjust the blood flow volume thereof; the simulated mitral valve 3 can simulate the natural mitral valve of the human body, and the simulated mitral valve 3 is connected between the simulated left ventricular cavity 10 and the simulated left atrial cavity 2, and the simulated mitral valve 3 is used to limit the simulated blood 105 pumped out by the simulated left atrial cavity 2 One-way flow to the simulated left ventricular cavity 10; the simulated aortic valve 4 can simulate the natural aortic valve of the human body, the simulated aortic valve 4 is connected to the outlet of the simulated left ventricular cavity 10, and the simulated aortic valve 4 is used to limit the simulated blood 105 pumped out of the simulated left ventricular cavity 10 to flow one-way to the simulated aorta 13; and an artificial heart pump 11 is connected between the outlet of the simulated left ventricular cavity 10 and the outlet of the simulated aortic valve 4, the artificial heart pump 11 can pump simulated blood 105 from the simulated left ventricular cavity 10 to the simulated aorta 13, and the artificial heart pump 11 is used to assist in pumping blood; the simulated aortic cavity 5 is connected to the outlet of the simulated aortic valve 4, and the simulated aortic cavity 5 can simulate the compliance of the aorta in the human body; one end of the simulated venous cavity 6 is connected to the outlet of the simulated aortic cavity 5, and the other end of the simulated venous cavity 6 is connected to the entrance of the simulated left atrial cavity 2, and the simulated venous cavity 6 can simulate the venous storage of blood in the human body.

[0051] Compared with the prior art, the test device of the artificial heart pump in this embodiment uses various mechanical structures to accurately simulate various key organs in the human body's blood circulation; the simulated left ventricular cavity 10, the simulated left atrial cavity 2, the simulated mitral valve 3, the simulated aortic valve 4, the simulated aortic cavity 5 and the simulated venous cavity 6 are formed by mechanical structure production, so that the simulated blood 105 can circulate in sequence among the simulated left atrial cavity 2, the simulated mitral valve 3, the simulated left ventricular cavity 10, the simulated aortic valve 4, the simulated aortic cavity 5, the simulated venous cavity 6 and the simulated left atrial cavity 2, thereby simulating various key organs in the human body's blood circulation by designing mechanical structures, thereby being able to more accurately reproduce the blood circulation process of the human body's natural heart; at the same time, the artificial heart pump 1 is connected between the outlet of the simulated left ventricular cavity 10 and the outlet of the simulated aortic valve 4 1, so that the artificial heart pump 11 can pump simulated blood 105 from the simulated left ventricular cavity 10 to the simulated aorta 13; and, the blood flow rate of the simulated left ventricular cavity 10 and the simulated left atrial cavity 2 can be adjusted according to the changes of the natural heart in different failure degrees and under different physiological conditions, so as to accurately simulate the actual working environment of the natural heart and the artificial heart pump 11 in the human body, so as to accurately simulate the hemodynamic characteristics of the natural heart in different failure degrees and under different physiological conditions, so as to accurately test the auxiliary blood pumping effect of the artificial heart pump 11 when the natural heart has different failure degrees and under different physiological conditions, and reversely verify the test results of the artificial heart pump 11 obtained through simulation according to the test results, thereby ensuring that the accuracy and reliability of the test results of the artificial heart pump 11 are high.

[0052] It is worth noting that since the simulated left ventricular cavity 10, simulated left atrial cavity 2, simulated mitral valve 3, simulated aortic valve 4, simulated aortic cavity 5 and simulated venous cavity 6 formed by the mechanical structure can accurately simulate the key organs in the human blood circulation, the artificial heart pump 11 can be tested for hydraulic performance and blood circulation outside the human body based on the test device of the artificial heart pump in this embodiment, thereby ensuring the comprehensiveness and completeness of the test of the artificial heart pump 11.

[0053] Furthermore, if Figure 1As shown, a manual ball valve 7 is connected between the artificial heart pump 11 and the simulated left ventricular cavity 10, and the manual ball valve 7 is used to control the connection or blockage between the artificial heart pump 11 and the simulated left ventricular cavity 10, so as to control the interventional blood pumping of the artificial heart pump 11 and the degree of interventional blood pumping according to the simulated left ventricular cavity 10 in different degrees of failure and different physiological states. In this embodiment, the common manual ball valve 7 in the prior art can be used, and the use of the manually operated manual ball valve 7 can make the reliability of the connection or blockage operation between the artificial heart pump 11 and the simulated left ventricular cavity 10 higher, so as to better ensure the accuracy and reliability of the test results of the artificial heart pump 11.

[0054] The structures of the simulated left ventricular cavity 10 and the simulated left atrial cavity 2 are described in detail below:

[0055] The simulated left ventricular cavity is the most critical structure in the entire artificial heart pump test device. By simulating the left ventricular cavity, the heart beat can be simulated to complete the pumping of blood. In the current simulated left ventricular cavity, the volume of the gas in the compressed container is usually used to simulate the heart beat to complete the pumping of blood. However, this simulation method is prone to slow response and is difficult to match the rapid response of the human body's natural heart. In addition, it is difficult to adjust the blood flow pumped out by the simulated left ventricular cavity using the output method of the air pump, thereby making it difficult to change the hemodynamic characteristics of the simulated left ventricular cavity pumping blood, and cannot meet the task requirements of in-depth research on artificial heart pumps.

[0056] In order to solve the above problems, Figure 1 As shown, the simulated left ventricular cavity 10 in this embodiment includes a driving motor 101 and a first hollow cylinder 1021; wherein the first hollow cylinder 1021 is fixedly connected to the test bench, simulated blood 105 is arranged in the first hollow cylinder 1021, and a first piston 1031 is sealed and slidably arranged in the first hollow cylinder 1021, and the output shaft of the driving motor 101 is used to connect with the first piston 1031, and the driving motor 101 is used to drive the first piston 1031 to slide back and forth along the height direction of the first hollow cylinder 1021, so that the first piston 1031 squeezes the simulated blood 105 downward and pumps it out along the outlet of the first hollow cylinder 1021 to the simulated aorta 13, and when the first piston 1031 moves upward to reset, the simulated blood 105 flows from the simulated left atrial cavity 2 into the first hollow cylinder 1021. wherein the driving motor 101 can specifically be a linear motor or a stepping motor. In this embodiment, the first hollow cylinder 1021 is a sealed cavity made of acrylic material.

[0057] The moving stroke and moving frequency of the first piston 1031 are controlled by the driving motor 101 to control the blood flow output and heart rate of the simulated left ventricular cavity 10, thereby being able to accurately simulate the periodic contraction and relaxation functions of the natural heart by simulating the left ventricular cavity 10. The simulation method in which the driving motor 101 drives the first piston 1031 makes the response rapid and accurate, thereby being able to match the rapid response characteristics of the natural heart of the human body; and, being able to simulate a variety of different working conditions of the natural heart, thereby being able to relatively easily change the hemodynamic characteristics of the simulated left ventricular cavity 10 pumping blood, thereby being able to meet the task requirements of in-depth research on the artificial heart pump 11.

[0058] Among them, various working conditions of a natural heart are simulated, for example, a natural heart in a sleeping state, a resting state, a slight exercise state, a vigorous exercise state, 10% heart failure, 20% heart failure, 30% heart failure, 40% heart failure or 50% heart failure.

[0059] Furthermore, if Figure 1 As shown, the simulated left ventricular cavity 10 also includes a slide and a slide bar 104; wherein the output shaft of the driving motor 101 is connected to the slide, and the driving motor 101 is used to drive the slide to slide back and forth along the height direction of the first hollow cylinder 1021; one end of the slide bar 104 is fixedly connected to the slide, and the other end of the slide bar 104 slides and is sealed and inserted into the first hollow cylinder 1021 downward, and the other end of the slide bar 104 is fixedly connected to the first piston 1031, so that the first piston 1031 can be driven by the slide bar 104 to slide back and forth in the first hollow cylinder 1021. The slide is specifically a linear slide.

[0060] Specifically, if Figure 1 As shown, when the simulated left ventricular cavity 10 is working, the driving motor 101 drives the slide to move downward along the height direction of the first hollow cylinder 1021, so that the slide drives the slide rod 104 to push the first piston 1031 downward to move, so that the first piston 1031 squeezes the simulated blood 105 in the first hollow cylinder 1021 downward, that is, it can simulate the contraction action of the left ventricular cavity in the human body, so that the simulated left ventricular cavity 10 pumps the simulated blood 105 toward the direction of the simulated aorta 13; when the simulated left ventricular cavity 10 ends its contraction, the driving motor 101 drives the slide to move upward along the height direction of the first hollow cylinder 1021, so that the slide drives the first piston 1031 to move upward through the slide rod 104 to control the volume in the first hollow cylinder 1021, so that the pressure in the first hollow cylinder 1021 is reduced, and at this time, the simulated liquid flows into the first hollow cylinder 1021 from the simulated left atrial cavity 2, that is, it can simulate the relaxation action of the left ventricular cavity in the human body.

[0061] Furthermore, by driving the motor 101 to control the reciprocating frequency and reciprocating stroke of the slide, the pumping characteristics of a normal heart, a heart with different degrees of failure, and a simulated left ventricular cavity 10 under different physiological conditions can be simulated; specifically, since the maximum capacity of a normal left ventricular cavity in the human body is about 300mL, the amount of blood pumped out by the left ventricular cavity at a time is about 70mL; therefore, in this embodiment, the inner diameter of the first hollow cylinder 1021 is 80mm, the height of the first hollow cylinder 1021 is 150mm, the rated load of the slide is 35kg, the travel speed of the slide is 1.5m / s, and the driving motor 101 is an 800w stepper motor, thereby being able to meet the application requirements of simulating different heart rates and different degrees of heart failure conditions by simulating the left ventricular cavity 10, thereby ensuring that the simulated left ventricular cavity 10 can more accurately simulate the left ventricular cavity in the human body.

[0062] Specifically, if Figure 1 As shown, the structure and working principle of the simulated left atrial cavity 2 are the same as the structure and working principle of the simulated left ventricular cavity 10, and the only difference is the setting of the working parameters of the reciprocating stroke and reciprocating frequency of the first piston 1031; therefore, in this embodiment, the structure and working principle of the simulated left atrial cavity 2 are not described in detail, and the above description of the structure and working principle of the simulated left ventricular cavity 10 is sufficient to ensure that the simulated left atrial cavity 2 can accurately simulate the left atrial cavity in the human body.

[0063] The structures of the simulated aortic valve 4 and the simulated mitral valve 3 are described in detail below:

[0064] At present, the simulated aortic valves in most in vitro blood circulation simulation test devices simply use a one-way valve structure to simulate the one-way flow function. Although the one-way flow function can be met, the flow resistance and along-the-way loss of the purely mechanical one-way valve structure are large, resulting in low accuracy of the blood pressure information obtained; moreover, the one-way valve structure does not have the physiological characteristics of the aortic valve in the human body, and it is difficult to accurately simulate the aortic valve in the human body.

[0065] In order to solve the above problems, the simulated aortic valve 4 in this embodiment includes a silicone gasket, a first acrylic flange and a second acrylic flange arranged oppositely; wherein the first acrylic flange is connected to the outlet of the first hollow cylinder 1021 simulating the left ventricular cavity 10, and the second acrylic flange is respectively connected to the inlet of the simulated aortic cavity 5 and the outlet of the artificial heart pump 11; the silicone gasket is connected between the first acrylic flange and the second acrylic flange, and the simulated blood 105 is limited to flow through the first acrylic flange through the silicone gasket to the second acrylic flange in one direction. In this embodiment, the thickness of the silicone gasket is about 0.5mm-1mm, and the inner diameter of the silicone gasket is about 25mm.

[0066] By setting up a simulated aortic valve 4 with a three-open structure consisting of a first acrylic flange, a silicone gasket and a second acrylic flange, on the one hand, the unidirectional flow effect of the simulated blood 105 during circulation can be ensured; on the other hand, the silicone gasket can make the simulated aortic valve 4 have the physiological characteristics of the aortic valve in the human body on the valve, so that the aortic valve in the human body can be accurately simulated, thereby ensuring that the test device of the entire artificial heart pump can better restore the blood circulation system in the human body, and ensuring that the test results of the artificial heart pump 11 are more accurate and reliable.

[0067] Specifically, if Figure 1 As shown, the structure and working principle of the simulated mitral valve 3 are the same as those of the simulated aortic valve 4, and their function is to ensure the unidirectional flow of the simulated blood 105 during circulation; here, the structure and working principle of the simulated mitral valve 3 are not described in detail, and the above description of the structure and working principle of the simulated aortic valve 4 can be referred to to ensure that the simulated mitral valve 3 can accurately simulate the mitral valve in the human body.

[0068] The structure of the simulated aorta cavity 5 is described in detail below:

[0069] Specifically, Figure 1 As shown, the simulated aorta cavity 5 includes a second hollow cylinder 51, which is fixedly connected to the test bench, and simulated blood 105 is arranged in the second hollow cylinder 51. In this embodiment, the second hollow cylinder 51 is a sealed cavity made of acrylic material, and the inner diameter of the second hollow cylinder 51 is 140 mm, the height of the second hollow cylinder 51 is 150 mm, and the volume of the second hollow cylinder 51 is about 2300 mL.

[0070] Specifically, in order to simulate the compliance of the aorta in the human body under various conditions, it is necessary to establish a relationship expression between the change in the air volume in the second hollow cylinder 51 and the compliance value of the aorta, that is, a relationship 1 based on the compliance of the aorta:

[0071]

[0072] ΔV in equation 1 air represents the change in the air volume in the second hollow cylinder 51, in mL; ΔP air represents the change in the air pressure in the second hollow cylinder 51, in mmHg, and C represents the compliance value of the aorta. After the simulated left ventricular cavity 10 pumps out the simulated blood 105 to the simulated aorta 13 each time, the air volume and air pressure in the second hollow cylinder 51 will change. Assume that the air volume and air pressure in the second hollow cylinder 51 before pumping blood are V and V, respectively. air1 , Pair1 After pumping blood, the air volume and air pressure in the second hollow cylinder 51 are V air2 , P air2 , then we have the following relation 2:

[0073]

[0074] Since the air in the second hollow cylinder 51 is in a sealed cavity, according to the complete gas state equation, the following equation 3 is obtained:

[0075] P air1 ·V air1 =P air2 ·V air2

[0076] Then the following relation 4 can be obtained from the above relation 2 and relation 3:

[0077] P air1 ·V air1 =(P air1 +ΔP air )·(V air1 -C·ΔP air )

[0078] And simplify the above relationship 4 to obtain the following relationship 5:

[0079] V air1 =C(P air1 +ΔP air )

[0080] Relative to atmospheric pressure P air1 For example, the change in the air pressure in the second hollow cylinder 51 is ΔP air is often very small, so (P air1 +ΔP air ) is approximately regarded as atmospheric pressure, that is, (P air1 +ΔP air ) is a constant; then the above relationship 5 can be used to obtain: there is a linear relationship between the compliance value C of the aorta and the air volume in the second hollow cylinder 51. Therefore, the compliance of the aorta can be directly modified by modifying the air volume in the second hollow cylinder 51, and the only variable that affects the air volume in the second hollow cylinder 51 is the liquid level height of the simulated blood 105 in the second hollow cylinder 51. Therefore, the compliance of the aorta can be changed by modifying the liquid level height of the simulated blood 105 in the second hollow cylinder 51.

[0081] For this reason, Figure 1As shown, the simulated aorta cavity 5 in this embodiment further includes an air pressure regulating valve 52 and a laser rangefinder 53; wherein the air pressure regulating valve 52 is disposed at the top end of the second hollow cylinder 51, and the air pressure regulating valve 52 is used to adjust the air volume in the second hollow cylinder 51, and the air volume in the second hollow cylinder 51 is linearly related to the compliance of the simulated aorta 13; the laser rangefinder 53 is disposed at the top end of the second hollow cylinder 51, and the laser rangefinder 53 is used to detect the liquid level of the simulated blood 105 in the second hollow cylinder 51, and the air volume in the second hollow cylinder 51 corresponds to the liquid level of the simulated blood 105 in the second hollow cylinder 51.

[0082] Specifically, since compliance is the most critical feature of the aorta in the human body, in order to simulate the compliance of the aorta in the human body by simulating the aortic cavity 5, the principle of gas compressibility is used in the second hollow cylinder 51 to adjust the air volume in the second hollow cylinder 51 through the air pressure regulating valve 52. That is, by directly adjusting the liquid level of the simulated blood 105 in the second hollow cylinder 51, the different compliances of the aorta in the human body can be accurately simulated, so as to better restore the blood circulation system in the human body.

[0083] The structure of the simulated vein cavity 6 is described in detail below:

[0084] Specifically, Figure 1 As shown, the simulated venous cavity 6 includes a third hollow cylinder, which is fixedly connected to the test bench and is used to store simulated blood 105; wherein, considering that the total amount of blood in the veins of the human body is about 3.6L, therefore, in this embodiment, the third hollow cylinder is designed as an acrylic sealed cavity with an inner diameter of 180mm and a height of 220mm, so that the total capacity of the entire third hollow cylinder is 5.6L, thereby ensuring that the simulated venous cavity 6 can meet the functional simulation requirements of venous storage of blood during blood circulation. wherein, a one-way valve 8 is connected between the simulated venous cavity 6 and the simulated left atrium cavity 2, and the one-way valve 8 is used to limit the one-way flow of the simulated blood 105 from the simulated venous cavity 6 to the simulated left atrium cavity 2.

[0085] It is worth mentioning that the veins in the human body are organs and tissues that recover and store blood. The compliance of the veins is particularly large compared to the compliance of the aorta and arteries at all levels. Therefore, when designing the simulated aortic cavity 5, the influence of the compliance of the veins can be ignored. It is only necessary to ensure that the simulated venous cavity 6 can simulate the characteristics of venous blood storage.

[0086] The structures of the ultrasonic blood flow meter 15, the electric proportional valve 9, the pressure sensor 12 and the control module are described in detail below:

[0087] Furthermore, since the blood flow information in the simulated vein 14 needs to be obtained during the test; Figure 1 As shown, the test device of the artificial heart pump in this embodiment also includes an ultrasonic blood flow meter 15, which is connected between the simulated aortic cavity 5 and the simulated venous cavity 6, and is used to detect the blood flow in the simulated vein 14; specifically, the ultrasonic blood flow meter 15 includes a detection host and a probe that is communicatively connected to the detection host, and the probe is used to detect the blood flow in the simulated vein 14 and feed it back to the detection host. The detection host specifically refers to all other structures in the ultrasonic blood flow meter 15 except the probe.

[0088] Specifically, the ultrasonic blood flow meter 15 in this embodiment is a flow structure specially used for blood flow measurement. The specific model of the ultrasonic blood flow meter 15 is T402-TB, and the specific range of the probe is ±12.5L / min, so as to meet the blood flow measurement requirements of the ultrasonic blood flow meter 15, so as to realize real-time monitoring of blood flow.

[0089] Furthermore, since the main factor affecting the peripheral resistance of blood circulation in the human body is the vascular radius, if Figure 1 As shown, the test device of the artificial heart pump in this embodiment also includes an electric proportional valve 9, which is connected between the second hollow cylinder 51 simulating the aortic cavity 5 and the third hollow cylinder simulating the venous cavity 6. The electric proportional valve 9 is used to adjust the percentage of its valve opening to simulate the change of the flow resistance of the circulating blood, so that the change of the peripheral resistance during the blood circulation in the human body can be accurately simulated by the electric proportional valve 9. In this embodiment, the specific model of the electric proportional valve 9 is EPV-375B, and the maximum flow coefficient Cv of the electric proportional valve 9 is 1.7.

[0090] Specifically, Figure 1 As shown, the test device of the artificial heart pump also includes a control module and a pressure sensor 12; wherein the control module is respectively connected to the drive motor 101 and the electric proportional valve 9, so that the start and stop of the drive motor 101 and the electric proportional valve 9 can be controlled through the control module, the drive stroke and drive frequency of the drive motor 101 can be controlled, and the percentage of the valve opening of the electric proportional valve 9 can be controlled; the pressure sensor 12 is used to measure blood pressure information, and the pressure sensors 12 are respectively installed in the simulated left ventricular cavity 10, the simulated aorta 13 and the simulated vein 14, so that the blood pressure information of the simulated left ventricular cavity 10, the blood pressure information of the simulated aorta 13 and the blood pressure information of the simulated vein 14 in the blood circulation can be obtained in real time, so that the blood pressure information of each different position can be obtained in real time.

[0091] In this embodiment, the specific model of the pressure sensor 12 is PX300, the measuring range of the pressure sensor 12 is 0-375 mmHg, and the measuring accuracy of the pressure sensor 12 is 0.2%, so that the pressure sensor 12 can meet the blood pressure measurement requirements at various positions.

[0092] It is worth noting that if Figure 1 As shown, silicone tubes are sequentially connected between the simulated left atrium cavity 2, simulated mitral valve 3, simulated left ventricular cavity 10, simulated aortic valve 4, simulated aortic cavity 5, electric proportional valve 9, ultrasonic blood analyzer 15, simulated venous cavity 6, one-way valve 8 and simulated left atrium cavity 2 to form a complete blood circulation system; and silicone tubes are also connected between the simulated left ventricular cavity 10, manual ball valve 7, artificial heart pump 11 and simulated aortic valve 4 to form an auxiliary blood pumping branch. The silicone tube can specifically simulate the aorta and vein in the human body.

[0093] Furthermore, if Figure 1 As shown, the control module includes a control cabinet, a data acquisition card 162, a physiological recorder, an industrial computer 161 and connecting wires; wherein, a controller and a corresponding driver for controlling two drive motors 101 in the simulated left ventricular cavity 10 and the simulated left atrial cavity 2 are placed in the control cabinet, and the industrial computer 161 sends instructions to the controller to complete the action of the drive motor 101 simulating the heart beat; the physiological recorder is connected to the detection host for communication, and the physiological recorder is used to obtain and record the detection information of the probe; the signals of the electric proportional valve 9, the pressure sensor 12 and the two drive motors 101 are transmitted through the digital The data acquisition card 162 obtains and transmits to the industrial computer 161; the physiological recorder separately obtains the detection signal of the detection host of the ultrasonic blood flow meter 15 and transmits it to the industrial computer 161 through the data acquisition card 162; and, in the control interface of the industrial computer 161, the hemodynamic characteristics of the artificial heart pump 11 under different degrees of heart failure and different physiological states can be obtained by modifying the movement stroke and movement frequency of the first piston 1031 in the simulated left ventricular cavity 10 and the simulated left atrial cavity 2, and the percentage of the valve opening of the electric proportional valve 9, thereby achieving the purpose of testing the artificial heart pump 11. The specific model of the physiological recorder in this embodiment is MP160, and the control cabinet and the industrial computer 161 in this embodiment are common control structures in the prior art. Here, the control principle of the control cabinet and the industrial computer 161 will not be described in detail.

[0094] The test device of the artificial heart pump in this embodiment can simulate and produce various key organs in the human body's blood circulation, ensuring that the entire artificial heart pump test device can better restore the blood circulation system in the human body, and can adjust the blood flow pumped out by the simulated left ventricular cavity 10 and the simulated left atrial cavity 2 according to the changes in the natural heart at different degrees of failure and under different physiological conditions, thereby accurately testing the auxiliary pumping effect of the artificial heart pump 11 when the natural heart has different degrees of failure and under different physiological conditions, thereby ensuring the accuracy and reliability of the test results of the artificial heart pump 11.

[0095] The above contents are only preferred embodiments of the present invention. For ordinary technicians in this field, according to the concept of the present invention, there will be changes in the specific implementation methods and application scopes. The content of this specification should not be understood as limiting the present invention.

Claims

1. A test device for an artificial heart pump, characterized in that: The invention comprises a test bench and the following components respectively arranged on the test bench: A simulated left ventricular cavity (10) is used to pump blood to a simulated aorta (13) and can adjust the blood flow rate; A simulated left atrial cavity (2) connected to the inlet of the simulated left ventricular cavity (10), wherein the simulated left atrial cavity (2) is used to return blood to the simulated left ventricular cavity (10) and can adjust the blood flow rate pumped out; a simulated mitral valve (3), connected between the simulated left ventricular cavity (10) and the simulated left atrial cavity (2), the simulated mitral valve (3) being used to limit the simulated blood (105) pumped out of the simulated left atrial cavity (2) to flow unidirectionally to the simulated left ventricular cavity (10); A simulated aortic valve (4) is connected to the outlet of the simulated left ventricular cavity (10), the simulated aortic valve (4) is used to limit the simulated blood (105) pumped out of the simulated left ventricular cavity (10) to flow unidirectionally to the simulated aorta (13), and an artificial heart pump (11) is connected between the outlet of the simulated left ventricular cavity (10) and the outlet of the simulated aortic valve (4), and the artificial heart pump (11) can pump the simulated blood (105) from the simulated left ventricular cavity (10) to the simulated aorta (13); A simulated aortic cavity (5) connected to the outlet of the simulated aortic valve (4), wherein the simulated aortic cavity (5) can simulate the compliance of the aorta; The simulated venous cavity (6) has one end connected to the outlet of the simulated aortic cavity (5) and the other end connected to the inlet of the simulated left atrial cavity (2). The simulated venous cavity (6) can simulate a vein to store blood.

2. The test device for an artificial heart pump according to claim 1, characterized in that: A manual ball valve (7) is connected between the artificial heart pump (11) and the simulated left ventricular chamber (10), and the manual ball valve (7) is used to control the connection or blocking between the artificial heart pump (11) and the simulated left ventricular chamber (10).

3. The test device for an artificial heart pump according to claim 1, characterized in that: The structure of the simulated left atrial cavity (2) is the same as the structure of the simulated left ventricular cavity (10); the simulated left ventricular cavity (10) comprises: A driving motor (101); A first hollow cylinder (1021) is connected to the test bench, wherein simulated blood (105) is arranged in the first hollow cylinder (1021), and a first piston (1031) is sealed and slidably arranged in the first hollow cylinder (1021), and the output shaft of the driving motor (101) is used to connect with the first piston (1031) to drive the first piston (1031) to slide back and forth along the height direction of the first hollow cylinder (1021), so that the first piston (1031) squeezes the simulated blood (105) downward and pumps it out along the outlet of the first hollow cylinder (1021) to the simulated aorta (13), and when the first piston (1031) moves upward to reset, the simulated blood (105) flows from the simulated left atrium cavity (2) into the first hollow cylinder (1021).

4. The test device for an artificial heart pump as claimed in claim 3, characterized in that: The simulated left ventricular cavity (10) further comprises: A slide, the output shaft of the driving motor (101) being connected to the slide, and being used to drive the slide to slide back and forth along the height direction of the first hollow cylinder (1021); A sliding rod (104) has one end connected to the sliding platform, and the other end slides downward and is sealedly inserted into the first hollow cylinder (1021) and connected to the first piston (1031).

5. The test device for an artificial heart pump according to any one of claims 1 to 4, characterized in that: The structure of the simulated mitral valve (3) is the same as that of the simulated aortic valve (4); the simulated aortic valve (4) comprises: A first acrylic flange and a second acrylic flange are arranged opposite to each other, wherein the first acrylic flange is connected to the outlet of the simulated left ventricular cavity (10), and the second acrylic flange is respectively connected to the inlet of the simulated aortic cavity (5) and the outlet of the artificial heart pump (11); A silicone gasket is connected between the first acrylic flange and the second acrylic flange, and the simulated blood (105) is limited to flow through the first acrylic flange through the silicone gasket to the second acrylic flange in a unidirectional manner.

6. The test device for an artificial heart pump according to any one of claims 1 to 4, characterized in that: The simulated aorta cavity (5) comprises: A second hollow cylinder (51) connected to the test bench, wherein simulated blood (105) is arranged in the second hollow cylinder (51); an air pressure regulating valve (52) disposed at the top end of the second hollow cylinder (51), the air pressure regulating valve (52) being used to adjust the air volume in the second hollow cylinder (51), and the air volume in the second hollow cylinder (51) is linearly related to the compliance of the simulated aorta (13); A laser rangefinder (53) is disposed at the top of the second hollow cylinder (51), and is used to detect the liquid level of the simulated blood (105) in the second hollow cylinder (51). The air volume in the second hollow cylinder (51) corresponds to the liquid level of the simulated blood (105) in the second hollow cylinder (51).

7. The test device for an artificial heart pump according to any one of claims 1 to 4, characterized in that: The simulated venous cavity (6) comprises: The third hollow cylinder is connected to the test bench, and the third hollow cylinder is used to store simulated blood (105).

8. The test device for an artificial heart pump according to claim 3 or 4, characterized in that: The test device of the artificial heart pump also includes: An ultrasonic blood flow meter (15) is connected between the simulated aortic cavity (5) and the simulated venous cavity (6), and the ultrasonic blood flow meter (15) is used to detect the blood flow in the simulated vein (14).

9. The test device for an artificial heart pump as claimed in claim 8, characterized in that: The test device of the artificial heart pump also includes: The electric proportional valve (9) is connected between the simulated aortic cavity (5) and the ultrasonic blood flow meter (15). The electric proportional valve (9) is used to adjust the percentage of opening of its valve port to simulate the change of flow resistance of circulating blood.

10. The test device for an artificial heart pump according to claim 9, characterized in that: The test device of the artificial heart pump also includes: A control module, respectively connected to the drive motor (101) and the electric proportional valve (9); The pressure sensor (12) is used to measure blood pressure information. The simulated left ventricular cavity (10), the simulated aorta (13) and the simulated vein (14) are respectively equipped with the pressure sensor (12).

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