Sample processing and scheduling system and control method

Abstract

The invention relates to the technical field of sample processing, and relates to a sample processing and scheduling system and a control method, and the method comprises the steps: controlling a reaction disc assembly to rotate according to a rotation period, and controlling the reaction disc assembly to progressively preset the number of cups in each rotation period; wherein the rotation period comprises a plurality of rotation stages; the duration of the rotation period and the interval duration of the plurality of rotation stages are determined according to the target reaction system; determining a target dilution cup and a target reaction cup in the reaction disc assembly according to the first target rotation period, the number of preset cup positions and the total number of cup positions in the reaction disc assembly; according to the target rotation period of the actions corresponding to sample, reagent, diluent and sample dilution in the sample processing task, the sampling needle assembly and the reagent needle assembly are controlled to execute the corresponding actions on the target dilution cup and the target reaction cup respectively, so that the sample processing task is completed. Therefore, the problems of low sample processing speed and high cost can be effectively solved.

Description

Technical Field

[0001] The present application relates to the field of sample processing technology, and in particular to a sample processing and scheduling system and a control method. Background Art

[0002] When testing samples of medical equipment in the laboratory, it is generally necessary to perform pre-treatment operations such as dilution or hemolysis and re-inspection operations on the samples.

[0003] In the prior art, in the pre-treatment operation of sample dilution, manufacturers usually use the next test cycle to perform pre-operation, that is, the test cycle originally planned to be used for new samples is used to perform pre-treatment such as dilution or hemolysis. This control method reduces the test speed of the entire machine. With each additional pre-treatment operation, the test speed drops by 50%. In addition, when performing re-inspection operations such as sample dilution and re-testing, manufacturers usually achieve this by aspirating the sample again and performing a second dilution operation. This is equivalent to performing two tests. Not only does it increase the amount of samples used and the demand for individual samples, but it also increases the number of uses of components such as sampling needles, reducing the service life of various consumables.

[0004] In short, the existing sample processing speed is low and the cost is high. Summary of the invention

[0005] In view of this, the embodiments of the present application provide a sample processing and scheduling system and control method, which can effectively solve the problems of low sample processing speed and high cost.

[0006] In a first aspect, an embodiment of the present application provides a control method for a sample processing and scheduling system, wherein the sample processing and scheduling system includes a reaction disk assembly, a sampling needle assembly, and a reagent needle assembly; the method includes:

[0007] The reaction disk assembly is controlled to rotate according to a rotation cycle, and each rotation cycle controls the cups in the reaction disk assembly to advance to a preset number of cups; wherein the rotation cycle includes a plurality of rotation stages; the duration of the rotation cycle and the interval duration of the plurality of rotation stages are determined according to the target reaction system;

[0008] Determine a target dilution cup and a target reaction cup in the reaction disc assembly according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disc assembly;

[0009] According to the target rotation cycle of the corresponding actions of sucking and adding samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup to complete the sample processing task.

[0010] In some embodiments, controlling the sampling needle assembly and the reagent needle assembly to perform corresponding actions on the target dilution cup and the target reaction cup includes:

[0011] According to the corresponding execution positions of the sampling needle assembly and the reagent needle assembly, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup; wherein the execution positions of the sampling needle assembly and the reagent needle assembly are determined according to each of the target rotation cycles, the preset number of cup positions, the total number of cup positions, and the number of cup positions rotated in the multiple rotation stages; each of the target rotation cycles is determined according to the target reaction system;

[0012] The sample processing and scheduling system further comprises a wiping assembly; a wiping position of the wiping assembly is fixedly arranged at a preset cup position of the reaction disk assembly.

[0013] In some embodiments, each of the rotation cycles includes three rotation stages; and controlling the reaction disk assembly to rotate according to the rotation cycle includes:

[0014] In each rotation cycle, the reaction disk assembly is controlled to rotate C1 cup positions in the first rotation stage, the reaction disk assembly is controlled to rotate C2 cup positions in the second rotation stage, and the reaction disk assembly is controlled to rotate C3 cup positions in the third rotation stage;

[0015] and / or,

[0016] According to the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup, including:

[0017] In the n1th rotation cycle, the diluent needle is controlled to add diluent to the target dilution cup, and the wiping component is controlled to wipe the target reaction cup at the preset cup position;

[0018] In the n2th rotation cycle, controlling the sampling needle assembly to add the original sample to the target dilution cup at the sample adding position;

[0019] In the n3th rotation cycle, controlling the reagent needle assembly to add reagent to the target reaction cup at the reagent adding position;

[0020] After the retest is determined, after the first rotation phase of the n4th rotation cycle ends, the sampling needle assembly is controlled to absorb the diluted sample for retest from the target dilution cup at the sample absorption and retest position; after the second rotation phase of the n4th rotation cycle ends, the absorbed diluted sample for retest is added to the target reaction cup; wherein the sample absorption and retest position is calculated based on the n1th rotation cycle, the n4th rotation cycle, the preset number of cup positions, the number of cups rotated in the first rotation phase, and the total number of cup positions. wherein n4>n3>n2>n1.

[0021] In some embodiments, the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task is used to control the sampling needle assembly and the reagent needle assembly to perform corresponding actions on the target dilution cup and the target reaction cup, respectively, including:

[0022] After the third rotation stage of the n1th rotation cycle ends, controlling the diluent needle to add diluent to the target dilution cup, and controlling the wiping component to wipe the target reaction cup at the preset cup position;

[0023] After the second rotation phase of the n2th rotation cycle ends, the sampling needle assembly is controlled to add the original sample to the target dilution cup at the sample adding position; wherein the sample adding position is calculated based on the n1th rotation cycle, the n2th rotation cycle, the preset number of cup positions, the number of cups rotated in the third rotation phase, and the total number of cup positions;

[0024] After the first rotation stage of the n3th rotation cycle is completed, the reagent needle assembly is controlled to add reagent to the target reaction cup at the reagent adding position; wherein the reagent adding position is calculated according to the n1th rotation cycle, the n3th rotation cycle, the preset number of cup positions, the number of cups rotated in the second rotation stage, the number of cups rotated in the third rotation stage and the total number of cup positions;

[0025] After determining to retest, after the first rotation stage of the n4th rotation cycle ends, the sampling needle assembly is controlled to absorb the diluted sample for retesting from the target dilution cup at the sample aspirating and retesting position; after the second rotation stage of the n4th rotation cycle ends, the absorbed diluted sample for retesting is added into the target reaction cup; wherein, the sample aspirating and retesting position is calculated based on the n1th rotation cycle, the n4th rotation cycle, the preset number of cup positions, the number of cups rotated in the first rotation stage and the total number of cup positions.

[0026] In some embodiments, the sample processing and scheduling system further comprises a cleaning component; and the method further comprises:

[0027] After the third rotation stage of the n5th rotation cycle ends, the cleaning component is controlled to clean the target dilution cup at the cleaning position; wherein the cleaning position is calculated according to the n1th rotation cycle, the n5th rotation cycle, the preset number of cup positions and the total number of cup positions;

[0028] After the second rotation phase of the n5th rotation cycle ends, the cleaning component is controlled to clean the target reaction cup according to the cleaning position.

[0029] In some embodiments, the cleaning position is calculated using the following formula:

[0030] W=((n5+1-n1)×g+1)%C

[0031] Among them, W is the cup position number corresponding to the cleaning position in the reaction disk assembly, n5 is the sequence number of the n5th rotation cycle, n1 is the sequence number of the n1th rotation cycle, g is the preset number of cup positions, and C is the total number of cup positions in the reaction disk assembly.

[0032] In some embodiments, the preset number of cups is calculated using the following formula:

[0033] g=|(C1+C2+C3)%C|

[0034] Wherein, C1 is the number of cups rotated in the first rotation stage, C2 is the number of cups rotated in the second rotation stage, C3 is the number of cups rotated in the third rotation stage, C is the total number of cup positions in the reaction disk assembly, and g is the preset number of cup positions;

[0035] The sample addition position is calculated using the following formula:

[0036] S=((n2-n1)×g+C3+1)%C

[0037] Wherein, S is the cup position number corresponding to the sample adding position in the reaction disk assembly, n1 is the sequence number of the n1th rotation cycle, and n2 is the sequence number of the n2th rotation cycle;

[0038] The reagent addition position is calculated using the following formula:

[0039] R=((n3-n1)×g+C2+C3)%C

[0040] Wherein, R is the cup position number corresponding to the reagent adding position in the reaction disk assembly, and n3 is the sequence number of the n3th rotation cycle;

[0041] The sample position of the suction weight measurement is calculated using the following formula:

[0042] S1=((n4+1-n1)×g-C1+1)%C

[0043] Wherein, S1 is the cup position number corresponding to the sample position for weight absorption measurement in the reaction disk assembly, and n4 is the sequence number of the n4th rotation cycle.

[0044] In some embodiments, the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, respectively controlling the sampling needle assembly and the reagent needle assembly to perform corresponding actions on the target dilution cup and the target reaction cup, further includes:

[0045] After the third rotation stage of the next rotation cycle of the n3th rotation cycle ends, the sampling needle assembly is controlled to absorb the diluted sample from the target dilution cup at the sample aspiration and re-measurement position, and then the sampling needle is controlled to discharge the diluted sample into the target reaction cup at the sample addition position.

[0046] In some embodiments, the method further comprises:

[0047] Before controlling the reaction disk assembly to rotate, the reaction disk assembly is also controlled to be initialized and reset, specifically including setting the cup number of each cup in the reaction disk assembly to be equal to the cup position number of the reaction disk assembly; controlling the wiping assembly in the sample processing and scheduling system to be in cup position 0;

[0048] And / or, determining the target dilution cup and the target reaction cup in the reaction disc assembly according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disc assembly includes:

[0049] The cup numbers of the target dilution cup and the target reaction cup are calculated according to the following calculation formula:

[0050] x1=(n1×g)%C

[0051] x2=x1-1

[0052] Among them, x1 is the cup number of the target dilution cup; x2 is the cup number of the target reaction cup; n1 is the serial number of the first target rotation cycle; C is the total number of cup positions included in the reaction disk assembly; and g is the preset number of cup positions.

[0053] In a second aspect, an embodiment of the present application provides a sample processing and scheduling system, the system comprising a controller, a sampling needle assembly, a reaction disk assembly and a reagent needle assembly; the controller adopts a control method of a sample processing and scheduling system provided in the first aspect of the present application to implement sample processing tasks.

[0054] The embodiments of the present application have the following beneficial effects:

[0055] In the present application, the reaction disk assembly is controlled to rotate according to a rotation cycle, and each rotation cycle controls the cups in the reaction disk assembly to advance to a preset number of cups; wherein, the rotation cycle includes multiple rotation stages; the duration of the rotation cycle and the interval duration of the multiple rotation stages are determined according to the target reaction system; according to the first target rotation cycle, the preset number of cups, and the total number of cup positions in the reaction disk assembly, the target dilution cup and the target reaction cup are determined in the reaction disk assembly; according to the target rotation cycle of the corresponding actions of aspirating and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup to complete the sample processing task. The present application includes reaction cups and dilution cups, and no additional pre-processing is required. Moreover, when retesting, the diluted sample is directly drawn from the dilution cup without the need for re-dilution operation, and the sample processing speed is high and the cost is low. BRIEF DESCRIPTION OF THE DRAWINGS

[0056] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0057] Figure 1 A schematic diagram of the structure of the sample processing and scheduling system according to an embodiment of the present application is shown;

[0058] Figure 2 A flow chart showing a control method of a sample processing and scheduling system according to an embodiment of the present application;

[0059] Figure 3 A timing diagram showing a control method of a sample processing and scheduling system according to an embodiment of the present application;

[0060] Figure 4 Another timing diagram of the control method of the sample processing and scheduling system according to the embodiment of the present application is shown;

[0061] Figure 5 A schematic diagram showing the execution positions of various components on a reaction disk in a control method of a sample processing and scheduling system according to an embodiment of the present application is shown;

[0062] Figure 6 A structural schematic diagram of a control device of a sample processing and scheduling system according to an embodiment of the present application is shown.

[0063] Description of main component symbols:

[0064] 110 - reaction disk assembly; 120 - sampling needle assembly; 130 - reagent needle assembly; 140 - wiping assembly; 150 - cleaning assembly; 610 - reaction disk control module; 620 - dilution cup reaction cup determination module; 630 - reagent sample operation module. DETAILED DESCRIPTION

[0065] The technical solutions in the embodiments of the present application will be described clearly and completely below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all of the embodiments.

[0066] The components of the embodiments of the present application generally described and shown in the drawings herein may be arranged and designed in various configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the application claimed for protection, but merely represents the selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application.

[0067] Hereinafter, the terms "including", "having" and their cognates that can be used in various embodiments of the present application are intended only to indicate specific features, numbers, steps, operations, elements, components or a combination of the foregoing items, and should not be understood as first excluding the existence of one or more other features, numbers, steps, operations, elements, components or a combination of the foregoing items or increasing the possibility of one or more features, numbers, steps, operations, elements, components or a combination of the foregoing items. In addition, the terms "first", "second", "third" and the like are only used to distinguish descriptions and cannot be understood as indicating or implying relative importance.

[0068] Unless otherwise defined, all terms (including technical terms and scientific terms) used herein have the same meanings as those generally understood by those skilled in the art to which the various embodiments of the present application belong. The terms (such as those defined in generally used dictionaries) will be interpreted as having the same meanings as the contextual meanings in the relevant technical field and will not be interpreted as having idealized meanings or overly formal meanings unless clearly defined in the various embodiments of the present application.

[0069] In conjunction with the accompanying drawings, some embodiments of the present application are described in detail below. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other.

[0070] In the prior art, it is customary to use the test cycle originally planned for new samples for pre-treatment such as dilution or hemolysis, but the speed decreases by 50% each time the pre-treatment is added. In addition, when the sample is diluted and retested, a second dilution operation is required, thereby increasing the amount of sample used and the hospital's requirements for individual blood collection. At the same time, it also increases the number of uses of components such as sampling needles and reduces the service life of various consumables. Therefore, the present application provides a sample processing and scheduling system and control method to increase the sample processing speed and reduce costs.

[0071] like Figure 1 As shown, the present application provides a sample processing and scheduling system, which exemplarily includes a controller, a reaction disk assembly 110, a sampling needle assembly 120, and a reagent needle assembly 130. Further, the system also includes a wiping assembly 140 and a cleaning assembly 150. The controller uses a control method of a sample processing and scheduling system provided by the present application to implement a sample processing task.

[0072] The control method of the sample processing and scheduling system is described below in conjunction with some specific embodiments.

[0073] Figure 2 A flow chart of a control method of a sample processing and scheduling system according to an embodiment of the present application is shown. Exemplarily, the control method of the sample processing and scheduling system includes the following steps:

[0074] S100, controlling the reaction disk assembly 110 to rotate according to a rotation cycle, and controlling each cup in the reaction disk assembly 110 to advance by a preset number of cups in each rotation cycle; wherein the rotation cycle includes a plurality of rotation stages; the duration of the rotation cycle and the interval duration of the plurality of rotation stages are determined according to a target reaction system. Each rotation cycle controls the cups in the reaction disk assembly 110 to advance or retreat by a preset number of cups.

[0075] Exemplarily, each of the rotation cycles includes three rotation stages; the controlling the reaction disk assembly 110 to rotate according to the rotation cycle includes:

[0076] In each rotation cycle, the reaction disk assembly 110 is controlled to rotate C1 cup positions in the first rotation stage, the reaction disk assembly 110 is controlled to rotate C2 cup positions in the second rotation stage, and the reaction disk assembly 110 is controlled to rotate C3 cup positions in the third rotation stage.

[0077] Furthermore, the preset number of cups is calculated using the following formula:

[0078] g=|(C1+C2+C3)%C|

[0079] Wherein, C1 is the number of cups rotated in the first rotation stage, C2 is the number of cups rotated in the second rotation stage, C3 is the number of cups rotated in the third rotation stage, C is the total number of cup positions in the reaction disk assembly 110, and g is the preset number of cup positions. Preferably, g=2, including one reaction cup and one dilution cup.

[0080] The reaction disk assembly 110 advances 2 cups per rotation cycle. That is, the preset number of cups includes two cups, namely, a dilution cup and a reaction cup. If the reaction disk rotates clockwise, the preset number of cups is advanced in the positive direction, (C1+C2+C3)%C=2. If the reaction disk rotates counterclockwise, the preset number of cups is advanced in the negative direction, (C1+C2+C3)%C=-2. When rotating counterclockwise, C1, C2, and C3 all take negative values.

[0081] S200 , determining a target dilution cup and a target reaction cup in the reaction disk assembly 110 according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disk assembly 110 .

[0082] S300, according to the target rotation cycle of the corresponding actions of sucking and adding samples, reagents, diluents, and diluting samples in the sample processing task, respectively control the sampling needle assembly 120 and the reagent needle assembly 130 to perform corresponding actions on the target dilution cup and the target reaction cup to complete the sample processing task.

[0083] Further, in step S300, controlling the sampling needle assembly 120 and the reagent needle assembly 130 to perform corresponding actions on the target dilution cup and the target reaction cup includes:

[0084] According to the corresponding execution positions of the sampling needle assembly 120 and the reagent needle assembly 130, the sampling needle assembly 120 and the reagent needle assembly 130 are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup; wherein the execution positions of the sampling needle assembly 120 and the reagent needle assembly 130 are determined according to each of the target rotation cycles, the preset number of cup positions, the total number of cup positions and the number of cup positions rotated in the multiple rotation stages; each of the target rotation cycles is determined according to the target reaction system. The sample processing and scheduling system also includes a wiping assembly 140; the wiping position of the wiping assembly 140 is fixedly set at the preset cup position of the reaction disk assembly 110. Exemplarily, the wiping position of the wiping assembly 140 is fixedly set at the No. 0 cup position. The total number of cup positions of the reaction disk assembly 110 is C, that is, the total number of cups in the reaction disk assembly 110 is C, and one cup is placed in one cup position. The sample adding position is S, S1 is the sample absorption and re-measurement position, the reagent adding position is R, and the cleaning position is W.

[0085] In one rotation cycle, the reaction disk assembly 110 rotates C1 cup positions for the first time. Figure 3 10a; the second turn C2 cup position, Figure 3 10b; the third turn C3 cup position, Figure 3 10c. Set the wiping position to cup position 0, S, R and W are all relative to the wiping position. The position where the sampling needle assembly 120 performs the injection of the original sample is the sample adding position S, the position where the sampling needle assembly 120 performs the suction and re-testing action is the suction and re-testing sample position S1, the position where the reagent needle assembly 130 performs the reagent injection action is the reagent adding position R, and the position where the cleaning assembly 150 performs the cleaning action is the cleaning position W.

[0086] The present application sets the target rotation periods corresponding to the aspiration and injection of samples, reagents, diluents, and diluted samples according to the different reaction times in the reaction system, that is, sets the subsequent target rotation periods n1, n2, n3, n4, and n5. It can be understood that the method also includes:

[0087] Before controlling the reaction disk assembly 110 to rotate, the reaction disk assembly 110 is also controlled to initialize and reset, specifically including setting the cup number of each cup in the reaction disk assembly 110 to be equal to the cup position number of the reaction disk assembly 110; and controlling the wiping assembly 140 in the sample processing and scheduling system to be at cup position 0. Demonstratively, after the instrument is started and the reset is completed, cup position 0 corresponds to cup No. 0, and cup position 1 corresponds to cup No. 1, that is, starting from cup position 0, the cup positions are arranged in a counterclockwise order. After the reset, it also includes: controlling the wiping assembly to wipe cup No. 0 on cup position 0, and controlling the diluent to add diluent to cup No. 1 on cup position 1. Among them, the wiping assembly is fixed at cup position 0.

[0088] The step of determining a target dilution cup and a target reaction cup in the reaction disk assembly 110 according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disk assembly 110 includes:

[0089] The cup numbers of the target dilution cup and the target reaction cup are calculated according to the following calculation formula:

[0090] x1=(n1×g)%C

[0091] x2=x1-1

[0092] Wherein, x1 is the cup number of the target dilution cup; x2 is the cup number of the target reaction cup; n1 is the serial number of the first target rotation cycle; C is the total number of cup positions included in the reaction disk assembly 110, and g is the preset number of cup positions. Preferably, g=2, including one reaction cup and one dilution cup. That is, x1=(n1×2)%C, x2=x1-1, and the reaction cup and the dilution cup are adjacent.

[0093] Further, each of the rotation cycles includes three rotation stages; and controlling the reaction disk assembly to rotate according to the rotation cycle includes:

[0094] In each rotation cycle, the reaction disk assembly is controlled to rotate C1 cup positions in the first rotation stage, the reaction disk assembly is controlled to rotate C2 cup positions in the second rotation stage, and the reaction disk assembly is controlled to rotate C3 cup positions in the third rotation stage.

[0095] According to the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup, including:

[0096] In the n1th rotation cycle, the diluent needle is controlled to add diluent into the target dilution cup, and the wiping component is controlled to wipe the target reaction cup at the preset cup position.

[0097] In the n2th rotation cycle, the sampling needle assembly is controlled to add the original sample to the target dilution cup at the sample adding position.

[0098] In the n3th rotation cycle, the reagent needle assembly is controlled to add reagent to the target reaction cup at the reagent adding position.

[0099] After determining to retest, in the n4th rotation cycle, the sampling needle assembly is controlled to absorb the diluted sample from the target dilution cup at the retest sample aspiration position; wherein n4>n3>n2>n1.

[0100] Furthermore, before controlling the reaction disk assembly to rotate, the reaction disk assembly is also controlled to initialize and reset. If, after the reset, cup No. 2 is at cup No. 0 and cup No. 3 is at cup No. 1, then after the third rotation stage of the 0th rotation cycle ends, cup No. 0 is at cup No. 0 and cup No. 1 is at cup No. 1. Figure 3 The operation corresponding to step 13a is to wipe cup 0 and add diluent to cup 1. If cup 0 is at cup position 0 and cup 1 is at cup position 1 after resetting, cup 0 is immediately at cup position 0 and cup 1 is at cup position 1 before the 0th rotation cycle, cup 0 is wiped and diluent is added to cup 1.

[0101] Further, in step S300, according to the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly 120 and the reagent needle assembly 130 are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup, including:

[0102] S310, after the third rotation stage of the n1th rotation cycle ends, control the diluent needle to add diluent to the target dilution cup; control the wiping assembly 140 to wipe the target reaction cup. In the counterclockwise direction, the diluent needle is at the next cup position to the wiping position. Exemplarily, after resetting, cup No. 2 is at cup position No. 0 and cup No. 3 is at cup position No. 1, then after the third rotation stage of the 0th rotation cycle ends, cup No. 0 is at cup position No. 0 and cup No. 1 is at cup position No. 1, as shown in FIG. Figure 3 The operation corresponding to 13a.

[0103] S320, after the second rotation phase of the n2th rotation cycle ends, the sampling needle assembly 120 is controlled to add the original sample to the target dilution cup at the sample adding position, such as Figure 3 The operation corresponding to step 11b; wherein the sample adding position is calculated based on the n1th rotation cycle, the n2th rotation cycle, the preset number of cup positions, the number of cups rotated in the third rotation stage and the total number of cup positions.

[0104] Exemplarily, the sample adding position is calculated using the following formula:

[0105] S=((n2-n1)×g+C3+1)%C

[0106] Wherein, S is the cup position number corresponding to the sample adding position in the reaction disk assembly 110 , n1 is the sequence number of the n1th rotation cycle, and n2 is the sequence number of the n2th rotation cycle.

[0107] S330, after the first rotation phase of the n3th rotation cycle ends, the reagent needle assembly 130 is controlled to add reagent to the target reaction cup at the reagent adding position, such as Figure 3 The operation corresponding to 12a in FIG. 12a; wherein the reagent adding position is calculated based on the n1th rotation cycle, the n3th rotation cycle, the preset number of cups, the number of cups rotated in the second rotation stage, the number of cups rotated in the third rotation stage and the total number of cup positions. Exemplarily, the reagent adding position is calculated using the following formula:

[0108] R=((n3-n1)×g+C2+C3)%C

[0109] Wherein, R is the cup position number corresponding to the reagent adding position in the reaction disk assembly 110, and n3 is the sequence number of the n3th rotation cycle.

[0110] S340, after determining to retest, after the first rotation phase of the n4th rotation cycle ends, control the sampling needle assembly to absorb the diluted sample for retesting from the target dilution cup at the retesting sample aspirating position, such as Figure 3The operation corresponding to 11a in 1; after the second rotation stage of the n4th rotation cycle, the diluted sample for re-testing is added to the target reaction cup; wherein the sample position for re-testing is calculated based on the n1th rotation cycle, the n4th rotation cycle, the preset number of cup positions, the number of cups rotated in the first rotation stage and the total number of cup positions. wherein the sample position for re-testing is calculated based on the n1th rotation cycle, the n4th rotation cycle, the preset number of cup positions, the number of cups rotated in the first rotation stage and the total number of cup positions; wherein n4>n3>n2>n1. illustratively, the sample position for re-testing is calculated using the following formula:

[0111] S1=((n4+1-n1)×g-C1+1)%C

[0112] Wherein, S1 is the cup position number corresponding to the sample position for weight absorption and measurement in the reaction disk assembly 110, and n4 is the sequence number of the n4th rotation cycle.

[0113] The method further comprises:

[0114] S350, after the third rotation stage of the next rotation cycle of the n3th rotation cycle ends, control the sampling needle assembly 120 to absorb the diluted sample from the target dilution cup at the sample aspiration and re-measurement position, and then control the sampling needle to discharge the diluted sample into the target reaction cup at the sample addition position.

[0115] Furthermore, the sample processing and scheduling system further comprises a cleaning component 150. The method further comprises:

[0116] S360, after the third rotation stage of the n5th rotation cycle ends, the cleaning component 150 is controlled to clean the target dilution cup at the cleaning position, such as Figure 3 The operation corresponding to 14b in FIG. 14b; wherein the cleaning position is calculated according to the n1th rotation cycle, the n5th rotation cycle, the preset number of cup positions and the total number of cup positions. After the second rotation phase of the n5th rotation cycle ends, the cleaning component 150 is controlled to clean the target reaction cup according to the cleaning position, such as Figure 3 The operation corresponding to 14a.

[0117] Furthermore, the cleaning position is calculated using the following formula:

[0118] W=((n5+1-n1)×g+1)%C

[0119] Among them, W is the cup position number corresponding to the cleaning position in the reaction disk assembly 110, n5 is the sequence number of the n5th rotation cycle, n1 is the sequence number of the n1th rotation cycle, g is the preset number of cup positions, and C is the total number of cup positions in the reaction disk assembly 110.

[0120] The following is an introduction to the control method of the sample processing and scheduling system of the present application with reference to a specific example. In this example, C=60, C1=-22, C2=-41, C3=-59, and each rotation cycle negatively progresses (C1+C2+C3)%C cups, i.e., 2 cups. After the reaction disk is reset, cup position 0 corresponds to cup position 0, the wiping assembly 140 is located at cup position 0, and cup No. 1 corresponds to cup position 1, and the cup positions are arranged in a counterclockwise order. After resetting, wipe cups No. 0 and No. 1 and add diluent. The cup positions are fixed on the reaction disk, and it is the individual cups that rotate. Figure 4 As shown, according to the reaction system, diluent is added before the 0th rotation cycle, sample and reagent are added in the 2nd cycle; diluted sample is added in the 3rd cycle; sample is re-tested in the 21st cycle, first cleaning is performed in the 24th cycle; second cleaning is performed in the 25th cycle; and third cleaning is performed in the 26th cycle. Therefore, n1=0, n2=2, n3=2, n4=21, n5=24. Figure 5 As shown, the wiping position is at cup position 0, the sample adding position is at S, the sample suction and re-measurement position is at S1, the reagent adding position is at R, and the cleaning position is at W. S, R, and W are all relative to the wiping position.

[0121] like Figure 6 As shown, the specific steps include:

[0122] S410, before the 0th rotation cycle, according to x1=(0×2)%60, x2=x1–1, we get n1=0, x1=1, cup 0 is the reaction cup, referred to as reaction cup 0, located at cup position 0; cup 1 is the dilution cup, referred to as dilution cup 1, located at cup position 1. That is, the dilution needle is controlled to add diluent to cup 1 at cup position 1, and the wiping component 140 is controlled to wipe cup 0 at cup position 0. That is, after resetting, wipe cup 0 immediately, and add the dilution cup to cup 1. If in the following example Figure 3 After the third rotation of the 0th rotation cycle shown in 13a, cup No. 0 is wiped and diluent is added to cup No. 1, so cup No. 2 should be stopped at cup No. 0 when resetting. The present application does not limit the cup position and cup number, and only needs to be inferred based on the corresponding relationship between the cup position number and the cup number when resetting.

[0123] S420, after the third rotation stage of the first rotation cycle ends, the reagent needle assembly 130 is controlled to absorb the reagent from the reagent kit. Figure 3 12b.

[0124] S430, if after resetting, cup No. 2 is at cup No. 0 and cup No. 3 is at cup No. 1, then in the second rotation cycle, n2=2, control the sampling needle assembly 120 to absorb the original sample, such as Figure 3 As shown in 11a; after the second rotation stage of the second rotation cycle, the dilution cup 1 rotates to the sample adding position S, and the sampling needle assembly 120 is controlled to discharge the original sample into the dilution cup. That is, the original sample is added to the No. 1 cup, S = ((2-0) × 2-59 + 1) % 60 = 6. That is, the original sample is added to the No. 6 cup position of the reaction disk. And because in the 0th cycle, Figure 3 In operation 13a, the diluent has been added to the dilution cup 1, so the sample dilution operation is now completed.

[0125] S440, if after resetting, cup No. 2 is at cup No. 0 and cup No. 3 is at cup No. 1, then when n3=2, after the first rotation stage of the second rotation cycle, dilution cup 1 rotates to the reagent adding position R, and the reagent needle assembly 130 is controlled to add reagent to dilution cup 1, R=((2-0)×2-41-59)%60=24. That is, the reagent needle assembly 130 is controlled to add reagent to dilution cup 1 at position 24 of the reaction disk.

[0126] S450, after the third rotation stage of the third rotation cycle ends, the sampling needle assembly 120 is controlled to be at the sample suction and retest position to suck the diluted sample from the dilution cup 1. Figure 3 11c when executing the action, Figure 5 At the S1 position in the dilution cup, the diluted sample is drawn from the dilution cup 1. After the diluted sample is drawn from the dilution cup 1, the sampling needle assembly 120 is controlled to Figure 3 At 11d, Figure 5 At position S of the , the diluted sample is discharged into the reaction cup 0. After completing this step, the sample begins to react with the reagent. The reagent Figure 3 During the reaction, the reaction data was continuously read.

[0127] S460, in the 21st rotation cycle, n4 = 21, when the reaction result can be calculated before the 21st cycle, and a judgment is made whether to retest. If retest is required, after the first rotation phase of the 21st cycle, the dilution cup 1 is located at S1 of the reaction disk, and the sampling needle is controlled to draw the retest sample from the dilution cup 1. That is, at this time, after the first rotation of the reaction disk assembly 110 in the 21st cycle, that is, Figure 3 After 10a (after the first rotation phase of the 21-cycle), the sampling needle is controlled to execute Figure 3 11a action, draw the retest sample from dilution cup 1. Draw the retest sample from cup 0, S1 = ((22-0) × 2 + 22 + 1) % 60 = 7. That is, draw the retest sample from cup 7 on the reaction disk. If retest is not required, Figure 3 When 11a is actuated, the sampling needle assembly 120 is controlled to absorb the original sample from the sample tube.

[0128] S470, n5=24, after the second rotation stage of the 24th rotation cycle ends (dilution cup 1: (24×2+22+41+1)%60=52; reaction cup: (24×2+22+41)%60=51), the cleaning component 150 is controlled to perform the first cleaning on the dilution cup 1, such as Figure 3 After the third rotation phase of the 24th rotation cycle ends ( Figure 3 14b) (dilution cup 1: (24×2+22+41+59+1)%60=51; reaction cup: (24×2+22+41+59)%60=50), control the cleaning component 150 at the W position, and perform the first cleaning on the reaction cup 0, such as Figure 3 The operation corresponding to 14b in FIG. 14b. Among them, the cleaning bit W = ((24 + 1-0) × 2 + 1) % 60 = 51. If three cleanings are required in the example, then in the next two cycles, cleaning is performed once in each cycle.

[0129] Figure 6 A schematic diagram of the structure of the control device of the sample processing and scheduling system of the embodiment of the present application is shown. Exemplarily, the control device of the sample processing and scheduling system includes: a reaction disk control module 610, a dilution cup reaction cup determination module 620 and a reagent sample operation module 630.

[0130] The reaction disk control module 610 is used to control the reaction disk assembly 110 to rotate according to a rotation cycle, and each rotation cycle controls each cup in the reaction disk assembly 110 to progressively advance a preset number of cups; wherein the rotation cycle includes multiple rotation stages; the duration of the rotation cycle and the interval duration of the multiple rotation stages are determined according to the target reaction system;

[0131] A dilution cup reaction cup determination module 620, for determining a target dilution cup and a target reaction cup in the reaction disk assembly 110 according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disk assembly 110;

[0132] The reagent sample operation module 630 is used to control the sampling needle assembly 120 and the reagent needle assembly 130 to perform corresponding actions on the target dilution cup and the target reaction cup according to the target rotation cycle of the corresponding actions of sucking and adding samples, reagents, diluents, and diluting samples in the sample processing task, so as to complete the sample processing task.

[0133] It can be understood that the device of this embodiment corresponds to the control method of the sample processing and scheduling system of the above embodiment, and the options in the above embodiment are also applicable to this embodiment, so they will not be described repeatedly here.

[0134] The present application also provides a terminal device, which exemplarily includes a processor and a memory, wherein the memory stores a computer program, and the processor runs the computer program to enable the terminal device to execute the control method of the sample processing and scheduling system or the functions of each module in the control device of the sample processing and scheduling system. The terminal device is a controller in the sample processing and scheduling system.

[0135] Among them, the processor can be an integrated circuit chip with signal processing capabilities. The processor can be a general-purpose processor, including a central processing unit (CPU), a graphics processing unit (GPU) and a network processor (NP), a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA) or at least one of other programmable logic devices, discrete gates or transistor logic devices, and discrete hardware components. The general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc., which can implement or execute the disclosed methods, steps and logic block diagrams in the embodiments of the present application.

[0136] The memory may be, but is not limited to, a random access memory (RAM), a read only memory (ROM), a programmable read-only memory (PROM), an erasable programmable read-only memory (EPROM), an electrically erasable programmable read-only memory (EEPROM), etc. The memory is used to store a computer program, and the processor may execute the computer program accordingly after receiving an execution instruction.

[0137] The present application also provides a computer-readable storage medium for storing the computer program used in the above-mentioned terminal device. For example, the computer-readable storage medium may include, but is not limited to, various media that can store program codes, such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk.

[0138] In several embodiments provided in the present application, it should be understood that the disclosed devices and methods can also be implemented in other ways. The device embodiments described above are merely schematic. For example, the flowcharts and structure diagrams in the accompanying drawings show the possible architecture, functions and operations of the devices, methods and computer program products according to multiple embodiments of the present application. In this regard, each box in the flowchart or block diagram can represent a module, a program segment or a part of a code, and the module, a program segment or a part of a code contains one or more executable instructions for implementing the specified logical function. It should also be noted that in an alternative implementation, the functions marked in the box can also occur in a different order from the order marked in the accompanying drawings. For example, two consecutive boxes can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the structure diagram and / or the flow diagram, and the combination of boxes in the structure diagram and / or the flow diagram, can be implemented with a dedicated hardware-based system that performs a specified function or action, or can be implemented with a combination of dedicated hardware and computer instructions.

[0139] In addition, the functional modules or units in the various embodiments of the present application may be integrated together to form an independent part, or each module may exist separately, or two or more modules may be integrated to form an independent part.

[0140] If the functions are implemented in the form of software function modules and sold or used as independent products, they can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or the part of the technical solution, can be embodied in the form of a software product, which is stored in a storage medium and includes several instructions for a computer device (which can be a smart phone, a personal computer, a server, or a network device, etc.) to perform all or part of the steps of the methods described in the various embodiments of the present application.

[0141] The above description is only a specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application.

Claims

1. A control method for a sample processing and scheduling system, characterized in that: The sample processing and scheduling system includes a reaction disk assembly, a sampling needle assembly and a reagent needle assembly; the method includes: The reaction disk assembly is controlled to rotate according to a rotation cycle, and each rotation cycle controls the cups in the reaction disk assembly to advance to a preset number of cups; wherein the rotation cycle includes a plurality of rotation stages; the duration of the rotation cycle and the interval duration of the plurality of rotation stages are determined according to the target reaction system; Determine a target dilution cup and a target reaction cup in the reaction disc assembly according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disc assembly; According to the target rotation cycle of the corresponding actions of sucking and adding samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup to complete the sample processing task.

2. The control method of the sample processing and scheduling system according to claim 1, characterized in that: The controlling the sampling needle assembly and the reagent needle assembly to perform corresponding actions on the target dilution cup and the target reaction cup includes: According to the corresponding execution positions of the sampling needle assembly and the reagent needle assembly, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup; wherein the execution positions of the sampling needle assembly and the reagent needle assembly are determined according to each of the target rotation cycles, the preset number of cup positions, the total number of cup positions, and the number of cup positions rotated in the multiple rotation stages; each of the target rotation cycles is determined according to the target reaction system; The sample processing and scheduling system further comprises a wiping assembly; a wiping position of the wiping assembly is fixedly arranged at a preset cup position of the reaction disk assembly.

3. The control method of the sample processing and scheduling system according to claim 2, characterized in that: Each of the rotation cycles includes three rotation stages; the step of controlling the reaction disk assembly to rotate according to the rotation cycle includes: In each rotation cycle, the reaction disk assembly is controlled to rotate C1 cup positions in the first rotation stage, the reaction disk assembly is controlled to rotate C2 cup positions in the second rotation stage, and the reaction disk assembly is controlled to rotate C3 cup positions in the third rotation stage; and / or, According to the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup, including: In the n1th rotation cycle, the diluent needle is controlled to add diluent to the target dilution cup, and the wiping component is controlled to wipe the target reaction cup at the preset cup position; In the n2th rotation cycle, controlling the sampling needle assembly to add the original sample to the target dilution cup at the sample adding position; In the n3th rotation cycle, controlling the reagent needle assembly to add reagent to the target reaction cup at the reagent adding position; After determining to retest, in the n4th rotation cycle, the sampling needle assembly is controlled to absorb the diluted sample from the target dilution cup at the retest sample aspiration position; wherein n4>n3>n2>n1.

4. The control method of the sample processing and scheduling system according to claim 3, characterized in that: According to the target rotation period of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup, including: After the third rotation stage of the n1th rotation cycle ends, controlling the diluent needle to add diluent to the target dilution cup, and controlling the wiping component to wipe the target reaction cup at the preset cup position; After the second rotation phase of the n2th rotation cycle ends, the sampling needle assembly is controlled to add the original sample to the target dilution cup at the sample adding position; wherein the sample adding position is calculated based on the n1th rotation cycle, the n2th rotation cycle, the preset number of cup positions, the number of cups rotated in the third rotation phase, and the total number of cup positions; After the first rotation stage of the n3th rotation cycle is completed, the reagent needle assembly is controlled to add reagent to the target reaction cup at the reagent adding position; wherein the reagent adding position is calculated according to the n1th rotation cycle, the n3th rotation cycle, the preset number of cup positions, the number of cups rotated in the second rotation stage, the number of cups rotated in the third rotation stage and the total number of cup positions; After determining to retest, after the first rotation stage of the n4th rotation cycle ends, the sampling needle assembly is controlled to absorb the diluted sample for retesting from the target dilution cup at the sample aspirating and retesting position; after the second rotation stage of the n4th rotation cycle ends, the absorbed diluted sample for retesting is added into the target reaction cup; wherein, the sample aspirating and retesting position is calculated based on the n1th rotation cycle, the n4th rotation cycle, the preset number of cup positions, the number of cups rotated in the first rotation stage and the total number of cup positions.

5. The control method of the sample processing and scheduling system according to claim 3, characterized in that: The sample processing and scheduling system also includes a cleaning component; the method also includes: After the third rotation stage of the n5th rotation cycle ends, the cleaning component is controlled to clean the target dilution cup at the cleaning position; wherein the cleaning position is calculated according to the n1th rotation cycle, the n5th rotation cycle, the preset number of cup positions and the total number of cup positions; After the second rotation phase of the n5th rotation cycle ends, the cleaning component is controlled to clean the target reaction cup according to the cleaning position.

6. The control method of the sample processing and scheduling system according to claim 5, characterized in that: The cleaning position is calculated using the following formula: W=((n5+1-n1)×g+1)%C Among them, W is the cup position number corresponding to the cleaning position in the reaction disk assembly, n5 is the sequence number of the n5th rotation cycle, n1 is the sequence number of the n1th rotation cycle, g is the preset number of cup positions, and C is the total number of cup positions in the reaction disk assembly.

7. The control method of the sample processing and scheduling system according to claim 4, characterized in that: The preset number of cups is calculated using the following formula: g=|(C1+C2+C3)%C| Wherein, C1 is the number of cups rotated in the first rotation stage, C2 is the number of cups rotated in the second rotation stage, C3 is the number of cups rotated in the third rotation stage, C is the total number of cup positions in the reaction disk assembly, and g is the preset number of cup positions; The sample addition position is calculated using the following formula: S=((n2-n1)×g+C3+1)%C Wherein, S is the cup position number corresponding to the sample adding position in the reaction disk assembly, n1 is the sequence number of the n1th rotation cycle, and n2 is the sequence number of the n2th rotation cycle; The reagent addition position is calculated using the following formula: R=((n3-n1)×g+C2+C3)%C Wherein, R is the cup position number corresponding to the reagent adding position in the reaction disk assembly, and n3 is the sequence number of the n3th rotation cycle; The sample position of the suction weight measurement is calculated using the following formula: S1=((n4+1-n1)×g-C1+1)%C Wherein, S1 is the cup position number corresponding to the sample position for weight absorption measurement in the reaction disk assembly, and n4 is the sequence number of the n4th rotation cycle.

8. The control method of the sample processing and scheduling system according to claim 7, characterized in that: According to the target rotation cycle of the corresponding actions of sucking and filling samples, reagents, diluents, and diluting samples in the sample processing task, the sampling needle assembly and the reagent needle assembly are respectively controlled to perform corresponding actions on the target dilution cup and the target reaction cup, and further includes: After the third rotation stage of the next rotation cycle of the n3th rotation cycle ends, the sampling needle assembly is controlled to absorb the diluted sample from the target dilution cup at the sample aspiration and re-measurement position, and then the sampling needle is controlled to discharge the diluted sample into the target reaction cup at the sample addition position to react the diluted sample with the reagent.

9. The control method of the sample processing and scheduling system according to any one of claims 1 to 8, characterized in that: The method further comprises: Before controlling the reaction disk assembly to rotate, the reaction disk assembly is also controlled to be initialized and reset, and the operation of the initialization and reset includes: setting the cup number of each cup in the reaction disk assembly to be equal to the cup position number of the reaction disk assembly, and controlling the wiping assembly in the sample processing and scheduling system to be in cup position 0; And / or, determining the target dilution cup and the target reaction cup in the reaction disc assembly according to the first target rotation cycle, the preset number of cup positions, and the total number of cup positions in the reaction disc assembly includes: calculating the cup numbers of the target dilution cup and the target reaction cup according to the following calculation formula: x1=(n1×g)%C x2=x1-1 Among them, x1 is the cup number of the target dilution cup; x2 is the cup number of the target reaction cup; n1 is the serial number of the first target rotation cycle; C is the total number of cup positions included in the reaction disk assembly; and g is the preset number of cup positions.

10. A sample processing and scheduling system, characterized in that: The system includes a controller, a sampling needle assembly, a reaction disk assembly and a reagent needle assembly; the controller uses the control method of the sample processing and scheduling system as described in any one of claims 1 to 9 to implement the sample processing task.

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