Simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging

Abstract

A simulation test device for human blood vessel magnetic imaging based on magnetic nanoparticles can realize accurate imaging of a specific area through directional distribution of the magnetic nanoparticles, facilitates development of magnetic nanoparticle magnetization response research and experimental verification of a magnetic source imaging technology, realizes cardiovascular magnetic plane images based on the magnetic nanoparticles, and has a good application prospect. The device is characterized by comprising a sensor array placing base with a sensor array placing clamping groove, a sensor placed in the clamping groove is a double-beam atom magnetometer, a silica gel hose simulating human blood vessel winding is arranged below the sensor array, one end of the silica gel hose is connected with the inlet end of a high-power pulsating pump, and the other end of the silica gel hose is connected with the outlet end of the high-power pulsating pump. One end of the double-beam atomic magnetometer is connected with the DBR laser, the other end of the double-beam atomic magnetometer is connected with the outlet end of the high-power pulsating pump, the double-beam atomic magnetometer is connected with the DBR laser through the laser beam splitter, the double-beam atomic magnetometer is located in the magnetic shielding cylinder and connected with the upper computer through the electric control board, and the outlet end of the high-power pulsating pump is provided with a magnetic source device which comprises a magnetic nanoparticle injection device and a magnetized magnet.

Description

Technical Field

[0001] The invention belongs to the technical field of magnetic field measurement, and in particular relates to a simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging. Background Art

[0002] The size of magnetic nanoparticles is very small, and the single-domain magnetic moment is highly unstable. In the absence of an external magnetic field, the magnetic moment can spontaneously flip under the action of thermal energy, showing no net magnetization, but under the action of an external magnetic field, the nanoparticles will show strong magnetization characteristics. Superparamagnetic iron oxide nanoparticles, as a negative contrast agent, can effectively shorten the transverse relaxation time of local magnetic resonance signals in cardiac magnetic resonance imaging and significantly improve imaging contrast. At the same time, they have low toxicity, safety and long-term availability in the body, making them have broad application prospects in clinical diagnosis.

[0003] As an instrument that measures magnetic fields by using the characteristics of atoms' response to external magnetic fields, atomic magnetometers have extremely high sensitivity and the ability to detect extremely weak magnetic fields. They are now widely used in medical imaging, geophysical exploration, and basic physics research. The dual-beam atomic magnetometer selectively excites atoms in a specific spin state through a circularly polarized pump beam, so that the atomic spins are arranged in a directional manner to form a spin polarization state. When atoms in a polarized state are exposed to an external magnetic field, the direction of the atomic spin will precess due to the force exerted by the magnetic field on the atomic torque. By measuring the Larmor frequency of the precession, the strength of the external magnetic field can be measured. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the related art. To this end, the present invention provides a simulation test device based on magnetic nanoparticle human vascular magnetic imaging. Through the directional distribution of magnetic nanoparticles, accurate imaging of specific areas can be achieved, which is conducive to the research on the magnetization response of magnetic nanoparticles and the experimental verification of magnetic source imaging technology, and the realization of cardiovascular magnetic planar images based on magnetic nanoparticles.

[0005] The technical solution of the present invention is as follows:

[0006] A simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging, characterized in that it comprises a sensor array placement base with a sensor array placement slot, the sensor placed in the slot is a double-beam atomic magnetometer, below the sensor array is a silicone hose wrapped around a simulated human blood vessel, one end of the silicone hose is connected to the inlet end of a high-power pulsating pump, the other end of the silicone hose is connected to the outlet end of the high-power pulsating pump, the double-beam atomic magnetometer is connected to a DBR laser through a laser beam splitter, the double-beam atomic magnetometer is located in a magnetic shielding cylinder, the double-beam atomic magnetometer is connected to a host computer through an electric control board, and a magnetic source device is provided at the outlet end of the high-power pulsating pump, the magnetic source device comprises a magnetic nanoparticle injection device for injecting magnetic nanoparticles into the silicone hose and a magnetizing magnet for magnetizing the magnetic nanoparticles.

[0007] The silicone hose is wound into a mosquito coil structure.

[0008] The sensor array is arranged in 2*4.

[0009] The magnetic shielding tube is composed of five layers of permalloy, the innermost layer and the outermost layer of the five cylindrical permalloy layers are both provided with magnetic field compensation coils, the side wall of the magnetic shielding tube is provided with a pipe inlet hole, and the sensor array placement base is placed on the partition inside the magnetic shielding tube.

[0010] The laser beam splitter splits the laser into two beams, one beam is used as detection light, and the other beam is used as pump light.

[0011] The electric control board includes a transimpedance amplifier, a photoelectric signal collector, a digital signal processor, a gas chamber heating controller and a linear power amplifier module, and the host computer is used to display time domain and frequency domain images.

[0012] The high-power pulsating pump is used to simulate heart pulsation, and includes a periodic pulsating circulation module, a liquid temperature control module and a pressure monitoring module. The periodic pulsating circulation module has an open atrium for receiving and storing liquid. The output port of the open atrium is connected to the silicone hose through an outlet ball valve controlled by a first voice coil motor, and the input port of the open atrium is connected to the silicone hose through an inlet ball valve controlled by a second voice coil motor.

[0013] The high-power pulsating pump is externally connected to a flow meter to monitor the simulated blood flow in real time.

[0014] The technical effects of the present invention are as follows: The present invention is a simulation test device based on magnetic nanoparticle human vascular magnetic imaging, relying on atomic magnetometer technology, array sensor system, magnetic nanoparticle preparation and functionalization technology and magnetic source imaging technology, and can utilize the superparamagnetic mechanism of magnetic nanoparticles to carry out magnetic nanoparticle magnetization response research and experimental verification of magnetic source imaging technology, and realize cardiovascular magnetic planar images based on magnetic nanoparticles.

[0015] The present invention can achieve precise imaging of specific areas through the directional distribution of magnetic nanoparticles, and can provide higher spatial resolution than traditional imaging technology. It is particularly suitable for detailed observation of magnetic field changes or structures in small areas and allows real-time dynamic imaging. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The present invention is a schematic diagram of the structure of a simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging.

[0017] Figure 2 yes Figure 1 Schematic diagram of the structural principle of medium and large power pulsating pumps.

[0018] Figure 3 This is a schematic diagram of the 2*4 sensor slot components inside the magnetic shielding barrel used in the experiment.

[0019] Figure 4 yes Figure 1 Schematic diagram of the structure of the silicone hose.

[0020] Figure 5 This is a schematic diagram of the cross-sectional structure of the magnetic shielding cylinder used in the experiment.

[0021] The description of the accompanying drawings is as follows: 1-high-power pulsating pump; 2-magnetized magnet; 3-magnetic nanoparticles; 4-silicone hose; 5-magnetic shielding tube; 6-dual-beam atomic magnetometer; 7-electric control board; 8-host computer; 9-laser beam splitter; 10-DBR laser (DBR, distributed Bragg reflector); 11-2*4 sensor array mounting base; 12-2*4 sensor array mounting slot; 13-first voice coil motor; 14-open atrium; 15-tube inlet hole; 16-outlet ball valve, 17-inlet ball valve; 18-second voice coil motor; 19-fluid direction. DETAILED DESCRIPTION

[0022] Below is the attached figure ( Figure 1-Figure 5 ) and Examples illustrate the present invention.

[0023] Figure 1The present invention is a schematic diagram of the structure of a simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging. Figure 2 yes Figure 1 Schematic diagram of the structural principle of medium and large power pulsating pumps. Figure 3 This is a schematic diagram of the 2*4 sensor slot components inside the magnetic shielding barrel used in the experiment. Figure 4 yes Figure 1 Schematic diagram of the structure of the silicone hose. Figure 5 This is a schematic diagram of the cross-sectional structure of the magnetic shielding cylinder used in the experiment. Figures 1 to 5 As shown, a simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging comprises a sensor array placement base (e.g., a 2*4 sensor array placement base 11) having a sensor array placement slot (e.g., a 2*4 sensor array placement slot 12), the sensor placed in the slot is a double-beam atomic magnetometer 6, below the sensor array is a silicone hose 4 wrapped around a simulated human blood vessel, one end of the silicone hose 4 is connected to the inlet end of a high-power pulsating pump 1, the other end of the silicone hose 4 is connected to the outlet end of the high-power pulsating pump 1, the double-beam atomic magnetometer 6 is connected to a DBR laser 10 via a laser beam splitter 9, the double-beam atomic magnetometer 6 is located in a magnetic shielding tube 5, the double-beam atomic magnetometer 6 is connected to a host computer 8 via an electric control board 7, and a magnetic source device is provided at the outlet end of the high-power pulsating pump 1, the magnetic source device comprises a magnetic nanoparticle injection device for injecting magnetic nanoparticles 3 into the silicone hose 4 and a magnetizing magnet 2 for magnetizing the magnetic nanoparticles 3.

[0024] like Figure 4 As shown, the silicone hose 4 is wound into a mosquito coil structure. Figure 3 As shown, the sensor array is arranged in 2*4, that is, 2*4 sensors are placed in a 2*4 sensor array placement slot. Figure 5 As shown, the magnetic shielding tube 5 is composed of five layers of permalloy, and the innermost layer and the outermost layer of the five cylindrical permalloy layers are both provided with magnetic field compensation coils. The side wall of the magnetic shielding tube is provided with a pipe inlet hole 15, and the sensor array placement base (for example, a 2*4 sensor array placement base 11) is placed on the partition inside the magnetic shielding tube 5.

[0025] The laser beam splitter 9 splits the laser into two beams, one as detection light and the other as pump light. The electric control board 7 includes a transimpedance amplifier, an optoelectronic signal collector, a digital signal processor, a gas chamber heating controller and a linear power amplifier module. The host computer 8 is used to display time domain and frequency domain images.

[0026] The high-power pulsating pump 1 is used to simulate heart pulsation, and includes a periodic pulsating circulation module, a liquid temperature control module and a pressure monitoring module. The periodic pulsating circulation module has an open atrium 14 for receiving and storing liquid. The output port of the open atrium 14 is connected to the silicone hose 4 through an outlet ball valve 16 controlled by a first voice coil motor 13, and the input port of the open atrium 14 is connected to the silicone hose 4 through an inlet ball valve 17 controlled by a second voice coil motor 18. The high-power pulsating pump 1 is externally connected to a flow meter to monitor the simulated blood flow in real time.

[0027] The present invention belongs to the field of magnetic field measurement technology, and in particular, relates to a simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging. The present invention aims to solve at least one of the technical problems existing in the related art. To this end, the present invention provides a simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging.

[0028] A simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging comprises the following steps:

[0029] S1: Test device system construction, including heart pulsation simulation device, magnetic shielding system, signal acquisition system, laser pumping and detection system;

[0030] S2: Build three groups of Helmholtz coils in the x, y, and z directions that are perpendicular to each other. The Helmholtz coils are located outside the mixed atomic vapor chamber and the non-magnetic heating system and inside the magnetic shielding system.

[0031] S3: Design a cylindrical magnetic shielding barrel to shield the Earth's magnetic field and create a weak magnetic environment;

[0032] S4: Based on the SHS-1800 high-flow pulsating pump (manufacturer: Shanghai Puren Medical Technology Co., Ltd.), the heart pulsation and human blood circulation functions are simulated, and the simulated blood flow is monitored in real time through an external flow meter;

[0033] S5: The magnetic properties of magnetic nanoparticles after magnetization are measured by a 2*4 dual-beam atomic magnetometer array, and the signal processing is realized through the electronic control board, and the time domain and frequency domain images are displayed in real time to the host computer.

[0034] The mixed atomic vapor chamber is an atomic gas chamber filled with alkali metal and inert gas.

[0035] The laser pumping and detection system comprises two vertically arranged lasers, and the two lasers are used for polarizing alkali metal atoms and detecting the spin states of alkali metal atoms respectively.

[0036] The non-magnetic heating system adopts non-magnetic materials to heat the mixed atomic vapor chamber.

[0037] The polarization state is realized by an electric control board, which mainly includes modules such as a transimpedance amplifier, a photoelectric signal collector, a digital signal processor, a gas chamber heating controller, and a linear power amplifier.

[0038] The magnetic shielding system is composed of five layers of cylindrical Permalloy, and the innermost layer and the outermost layer of the five layers of cylindrical Permalloy are provided with magnetic field compensation coils.

[0039] Figure 1 It shows the composition of each module of the present invention, wherein a high-power pulsating pump 1 is used to simulate heart pulsation; a magnetized magnet 2 is used to apply an external magnetic field to magnetize nanoparticles; magnetic nanoparticles 3 are used as the magnetic source of the device; a silicone hose 4 is used to simulate human blood vessels, and the winding method is a mosquito coil; a magnetic shielding tube 5 is used to shield the external interference magnetic field, and the tube is composed of five layers of Permalloy; a dual-beam atomic magnetometer 6 is used as a magnetic field sensor to detect the magnetic signal of nanoparticles; an electric control board 7 is a core component for signal processing; a host computer 8 is used to display time domain and frequency domain images; a laser beam splitter 9: splits the laser into two beams, one beam is used as a detection light, and the other beam is used as a pump light; a DBR laser 10 is used to provide a laser light source. Figure 2 The driving pump principle used in the simulated heart is shown, wherein the voice coil motor 13 is used to control the pulsating flow; and the open atrium 14 is used to receive and store liquid. Figure 3 The figure shows the 2*4 sensor slot components inside the magnetic shielding barrel used in the experiment. The slot is used to place the dual-beam atomic magnetometer, and the space at the bottom is reserved for placing the mosquito coil-type silicone tube to achieve real-time monitoring of the simulated blood vessels. Figure 3 A 2*4 sensor array placement slot 12 is provided on the 2*4 sensor array placement base 11 , and the silicone hose 4 is coiled below the 2*4 sensor array placement slot 12 . Figure 4 It shows the mosquito coil-shaped silicone tube used in the experiment, which is used to achieve long-term retention of magnetic nanoparticles and make the detection signal clearer. Figure 5 The cross-sectional structure diagram of the magnetic shielding cylinder used in the experiment is shown, in which the through holes on both sides are the entry holes for the silicone tube, and the slot component for placing a 2*4 sensor array above the partition. Figure 5 The 2*4 sensor array placement base 11 is set on the partition, the pipe inlet hole 15 is located on the left and right side walls of the magnetic shielding tube 5 below the partition, and the silicone hose 4 is located in the 2*4 sensor array placement base 11.

[0040] A simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging comprises the following steps:

[0041] S1: Test equipment construction, including heart pulsation simulation system, non-magnetic heating system, magnetic shielding system, signal acquisition system, laser pumping and detection system;

[0042] S2: Turn on the high-power pulsating pump and wait for two minutes before injecting the magnetic nanoparticles;

[0043] In this step, the cardiac pulsation simulation system is implemented by a high-power pulsating pump model SHS-1800 (manufacturer: Shanghai Purin Medical Technology Co., Ltd.), whose maximum output power can reach 850W, and the internal modules include a periodic pulsating circulation module, a liquid temperature control module and a pressure monitoring module; the periodic circulation module includes an open atrium, 2 built-in ball valves, a voice coil motor and a compliance module, and the periodic pulsating flow of the liquid can be achieved by controlling the movement of the motor. The liquid temperature control module uses a temperature sensor model NTC3950-10K (manufacturer: Shenzhen Ruitan Technology Co., Ltd.), and the pressure monitoring module uses a UATH pressure sensor (manufacturer: Shenzhen Langtai Electronic Technology Co., Ltd.).

[0044] Using superparamagnetic iron oxide nanoparticles as a magnetic source, they pinpoint where blood is flowing.

[0045] S3: The pulsating pump is connected to an external flow meter to measure the flow of the fluid in the silicone tube in real time.

[0046] S4: Turn on the magnetometer switch to put the magnetometer into working state, and cooperate with the electronic control board to monitor the distribution of magnetic field signals of magnetic nanoparticles in time domain and frequency domain in real time.

[0047] Magnetic shielding barrels are used to shield the Earth's magnetic field and create a weak magnetic environment required for the normal operation of the magnetometer. In order to guide the magnetic field lines more evenly and reduce the local magnetic field enhancement or weakening effect, the magnetic shielding barrel is designed to be cylindrical. High magnetic permeability Permalloy material is used in the barrel to guide the magnetic field lines to prevent them from entering the protected area. The outer shell of the barrel is composed of multiple layers of shielding materials, each layer of material has a different magnetic permeability to increase the shielding effect. It is also equipped with an active magnetic compensation coil to monitor and generate a reverse magnetic field in real time to offset the impact of external magnetic field changes on the internal space.

[0048] A high-precision vibration isolation platform is used to isolate external vibrations and provide a stable working environment for the magnetometer.

[0049] Through the directional distribution of magnetic nanoparticles, the test device can achieve precise imaging of specific areas and can provide higher spatial resolution than traditional imaging techniques. It is particularly suitable for detailed observation of magnetic field changes or structures in small areas and allows real-time dynamic imaging.

[0050] The contents not described in detail in the specification of the present invention belong to the prior art known to the professional and technical personnel in the field. It is pointed out here that the above description helps those skilled in the art to understand the invention, but does not limit the protection scope of the invention. Any equivalent replacement, modification and / or simplification of the above description without departing from the essence of the invention falls within the protection scope of the invention.

Claims

1. A simulation test device based on magnetic nanoparticle human vascular magnetic imaging, characterized in that: The invention comprises a sensor array placement base with a sensor array placement card slot, wherein the sensor placed in the card slot is a double-beam atomic magnetometer, and below the sensor array is a silicone hose wrapped around a simulated human blood vessel, one end of the silicone hose is connected to the inlet end of a high-power pulsating pump, and the other end of the silicone hose is connected to the outlet end of the high-power pulsating pump, the double-beam atomic magnetometer is connected to a DBR laser through a laser beam splitter, the double-beam atomic magnetometer is located in a magnetic shielding cylinder, and the double-beam atomic magnetometer is connected to a host computer through an electric control board, and a magnetic source device is arranged at the outlet end of the high-power pulsating pump, and the magnetic source device comprises a magnetic nanoparticle injection device for injecting magnetic nanoparticles into the silicone hose and a magnetizing magnet for magnetizing the magnetic nanoparticles.

2. The simulation test device based on magnetic nanoparticle human vascular magnetic imaging according to claim 1, characterized in that: The silicone hose is wound into a mosquito coil structure.

3. The simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging according to claim 1, characterized in that: The sensor array is arranged in 2*4.

4. The simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging according to claim 1, characterized in that: The magnetic shielding tube is composed of five layers of permalloy, the innermost layer and the outermost layer of the five cylindrical permalloy layers are both provided with magnetic field compensation coils, the side wall of the magnetic shielding tube is provided with a pipe inlet hole, and the sensor array placement base is placed on the partition inside the magnetic shielding tube.

5. The simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging according to claim 1, characterized in that: The laser beam splitter splits the laser into two beams, one beam is used as detection light, and the other beam is used as pump light.

6. The simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging according to claim 1, characterized in that: The electric control board includes a transimpedance amplifier, a photoelectric signal collector, a digital signal processor, a gas chamber heating controller and a linear power amplifier module, and the host computer is used to display time domain and frequency domain images.

7. The simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging according to claim 1, characterized in that: The high-power pulsating pump is used to simulate heart pulsation, and includes a periodic pulsating circulation module, a liquid temperature control module and a pressure monitoring module. The periodic pulsating circulation module has an open atrium for receiving and storing liquid. The output port of the open atrium is connected to the silicone hose through an outlet ball valve controlled by a first voice coil motor, and the input port of the open atrium is connected to the silicone hose through an inlet ball valve controlled by a second voice coil motor.

8. The simulation test device based on magnetic nanoparticle human blood vessel magnetic imaging according to claim 1, characterized in that: The high-power pulsating pump is externally connected to a flow meter to monitor the simulated blood flow in real time.

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