129results about "Measurements of magnetic particles" patented technology

A ferromagnetic thin-film based magnetic field detection system having a substrate supporting a magnetic field sensor in a channel with a first electrical conductor supported on the substrate positioned at least in part along the channel gap and in direct contact with at least some surface of the magnetic field sensor ands a second electrical conductor supported on the substrate positioned at least in part along the channel gap in a region thereof adjacent to, but separated from, the magnetic field sensor.

The invention discloses a magnetic nano temperature imaging method. The method includes applying a constant direct-current magnetic field and a constant alternating-current magnetic field to an area where magnetic nanoparticle samples are positioned at the same time, collecting alternating-current magnetized strength signals of magnetic nanoparticles, and detecting out each odd harmonic amplitude value; replacing a constant direct-current gradient field by a combined direct-current magnetic field containing a gradient magnetic field, collecting alternating-current magnetized strength signals of the magnetic nanoparticles, and detecting out each odd harmonic amplitude value; calculating difference of the harmonic amplitude values of the two times; utilizing Taylor series of a Langevin function to unfold and establish a relation formula of the odd harmonic amplitude values and temperature, and solving the relation formula to acquire in-vivo temperature; changing the direct-current gradient field to a next position until temperature measuring of the whole one-dimensional space is completed. Different exciting magnetic fields are applied to the magnetic nanoparticles, so that temperature imaging of the one-dimensional space is converted into solving of point temperature of each minizone, and a temperature field of the one-dimensional space can be precisely and quickly acquired without knowing concentration of the magnetic nanoparticles.

A magnetic sensor device (300) for sensing magnetic particles (15), the magnetic sensor device (300) comprising a magnetic field generator unit (12) adapted for generating a magnetic field, an excitation signal source (302) adapted for supplying the magnetic field generator unit (12) with a static electric excitation signal, an excitation switch unit (303) adapted for switching between different modes of electrically coupling the excitation signal source (302) to the magnetic field generator unit (12), and a sensing unit (11) adapted for sensing a signal indicative of the presence of the magnetic particles (15) in the generated magnetic field.

Sequencing-by-synthesis (SBS) method is provided that includes providing a detection apparatus that includes an array of magnetically-responsive sensors. Each of the magnetically-responsive sensors islocated proximate to a respective designated space to detect a magnetic property therefrom. The detection apparatus also includes a plurality of nucleic acid template strands located within corresponding designated spaces. The method also includes conducting a plurality of SBS events to grow a complementary strand by incorporating nucleotides along each template strand. At least some of the nucleotides are attached to corresponding magnetic particles having respective magnetic properties. Each of the plurality of SBS events includes detecting changes in electrical resistance at the magnetically-responsive sensors caused by the respective magnetic properties of the magnetic particles. The method also includes determining genetic characteristics of the complementary strands based on the detected changes in electrical resistance.

A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.

A sensor device for sensing magnetic particles, the sensor device including a substrate and a sensing unit provided on and / or in and / or near the substrate. The sensing unit is configured to sense a detection signal indicative of the presence of the magnetic particles. The sensor device further includes a magnetic field control unit which may be provided off the substrate and is configured to generate a time-dependent magnetic field for interaction with the magnetic particles.

The present invention can provide a method of determining the presence, location, quantity, or a combination thereof, of a biological substance, comprising: (a) exposing a sample to a plurality of targeted nanoparticles, where each targeted nanoparticle comprises a paramagnetic nanoparticle conjugated with one or more targeting agents that preferentially bind with the biological substance, under conditions that facilitate binding of the targeting agent to at least one of the one or more biological substances; (b) subjecting the sample to a magnetic field of sufficient strength to induce magnetization of the nanoparticles; (c) measuring a magnetic field of the sample after decreasing the magnetic field applied in step b below a threshold; (d) determining the presence, location, quantity, or a combination thereof, of the one or more biologic substances from the magnetic field measured in step (c).

A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scanned to optimize scan time, scanning power, amplifier heating, SAR, dB / dt, and / or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.