High-precision magnetic nano temperature estimation method and system based on Fokker-Planck

Abstract

The invention provides a high-precision magnetic nano temperature estimation method and system based on Fokker-Planck. The method comprises: constructing a magnetic nanoparticle temperature estimationmodel through a Fokker-Planck formula, measuring the magnetization response harmonic amplitude and phase information of the magnetic nanoparticles multiple times through a magnetic field informationdetection device, and fitting model parameters in the magnetic nanoparticle temperature estimation model; placing a sample to be detected in the magnetic field information detection device, measuringand substituting the harmonic amplitude and phase information of the sample under the excitation of an external magnetic field into the preset magnetic nanoparticle temperature estimation model, and solving the magnetic nanoparticle temperature information. According to the invention, the temperature information of the magnetic nanoparticles under the excitation of a medium-high frequency magneticfield can be accurately obtained. The problem that the conventional Langevin Function is not suitable on occasions of medium-high frequency excitation is solved, the application fields of magnetic nano temperature measurement and magnetic nano particle imaging technologies are expanded, and the measurement precision and the time-space resolution are improved.

Description

technical field [0001] The invention relates to the technical field of nanomagnetic detection technology and non-invasive temperature measurement, in particular to a high-precision magnetic nanometer temperature estimation method and system based on Fokker-Planck, which is suitable for magnetic nanometer temperature measurement or magnetic Nanoparticle imaging technology solves the bottleneck in the application field caused by the low excitation magnetic field of magnetic nanometer temperature measurement. Background technique [0002] Magnetic nanoparticle tumor hyperthermia is considered to be a green therapy for tumors and cancers due to its advantages of strong targeting, non-invasiveness, safety and less toxic side effects. Temperature is a very critical physical parameter in magnetic nano-tumor hyperthermia. However, the real-time and accurate measurement of temperature information in the cancerous tumor area is an important prerequisite and basis for precise applicat...

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Problems solved by technology

[0005] Aiming at the influence of the Brownian or Neel magnetization phenomenon on the harmonic amplitude information of the magnetization response under the medium-high frequency magnetic field excitation, the Langevin function cannot accurately describe the magnetization response information of the magnetic nanoparticle size under the medium-high frequency excitation. For the technical problem of low measurement accuracy, the present invention proposes a high-precision magnetic nanometer temperature estimation method and system based on Fokker-Planck, which compensates the harmonic amplitude information of the magnetization response through the harmonic amplitude and phase information in the magnetization response , so that it can accurately describe the harmonic information of the magnetic nanoparticle magnetization response under the excitation of the medium and high frequency magnetic field, and then realize the estimation of the temperature information under the excitation of the medium and high frequency magnetic field, and overcome the magnetic nanometer temperature measurement accuracy and spatial resolution caused by the low excitation frequency in the past It is expected to realize real-time temperature information measurement under the excitation of medium and high frequency magnetic fields, so as to meet the measurement accuracy, real-time performance and performance of magnetic nanometer temperature measurement and magnetic nanoparticle imaging technology required by medical biological diagnosis and industrial fields. Requirements for indicators such as spatial resolution

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