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Open type magnetic particle three-dimensional imaging system and method based on array type receiving coil

A receiving coil and three-dimensional imaging technology, which is applied in the field of biomedical imaging, can solve problems affecting imaging accuracy and achieve the effects of improving imaging accuracy, improving traversal efficiency, and increasing imaging speed

Active Publication Date: 2021-09-24
INST OF AUTOMATION CHINESE ACAD OF SCI
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Problems solved by technology

When the imaging field of view increases, it is obvious to increase the receiving coil to obtain a larger detection range; but the sensitivity uniformity of the large receiving coil is not as good as that of the small receiving coil, which will also affect the final imaging accuracy

Method used

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  • Open type magnetic particle three-dimensional imaging system and method based on array type receiving coil
  • Open type magnetic particle three-dimensional imaging system and method based on array type receiving coil
  • Open type magnetic particle three-dimensional imaging system and method based on array type receiving coil

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no. 3 example

[0088] The third embodiment of the present invention, refer to image 3 , the application provides an open magnetic particle three-dimensional imaging method based on an array receiving coil, the method comprising the following steps:

[0089] Step S100, passing a direct current into the magnetic field-free imaging unit, so that no magnetic field lines are generated at the center of the imaging field of view of the non-magnetic field line imaging unit, and the non-magnetic field line imaging unit includes an array receiving coil;

[0090] Step S200, controlling the spatial position of the non-magnetic field lines by adjusting the current, and controlling the non-magnetic field lines to traverse the imaging field of view, so as to complete the three-dimensional scanning detection of the imaging field of view;

[0091] Step S300, detecting the induced voltage signal through the array receiving coil, sequentially filtering the base frequency and amplifying the voltage signal, and...

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Abstract

The invention relates to the field of biomedical imaging and particularly relates to an open type magnetic particle three-dimensional imaging system and method based on array type receiving coils, and aims to solve a problem of contradiction between imaging precision and imaging speed in the prior art. The system comprises a non-magnetic field line generation module, a non-magnetic field line driving module, a signal detection module, a current excitation module, a signal conditioning module and an image reconstruction module. The imaging method comprises the following steps that a non-magnetic field line is constructed; the spatial position of the non-magnetic field line is adjusted by adjusting the current; an array type receiving coil of the signal detection module is used for detecting an induced voltage signal, then the induced voltage signal is processed by the signal conditioning module to obtain a signal without a fundamental frequency component, a direct current component in the voltage signal is filtered out by a digital filtering technology, and then Fourier transform is carried out on the voltage signal to obtain a frequency spectrum sequence of the voltage signal; and a measurement matrix of the array type receiving coil is constructed, and magnetic particle concentration space distribution is calculated by using the frequency spectrum sequence and the measurement matrix to realize three-dimensional high-precision rapid imaging.

Description

technical field [0001] The invention belongs to the field of biomedical imaging, and in particular relates to an open magnetic particle three-dimensional imaging system and method based on array receiving coils. Background technique [0002] Magnetic particles, which are nanoscale particles with superparamagnetism, have been widely studied and applied as new medical imaging tracers. Magnetic particle imaging is a quantitative imaging technique that uses field free region (FFR) time-space encoding to excite and receive magnetization response signals of magnetic particles, and then reconstruct the concentration distribution of magnetic particles in the human body. It has submillimeter resolution and has important research and application value in clinical problems such as tumor detection, magnetic particle hyperthermia, and targeted drug delivery. [0003] The first task of magnetic particle imaging is to construct FFR and encode it in time and space. The currently used FFR ...

Claims

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Application Information

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IPC IPC(8): G01R33/12A61B5/0515
CPCG01R33/1276A61B5/0515A61B5/725A61B5/7257
Inventor 田捷刘晏君惠辉张浩然杨鑫
Owner INST OF AUTOMATION CHINESE ACAD OF SCI
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