Blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system

Abstract

The invention provides a blood pressure data acquisition mechanism, electronic equipment, a medical catheter and an ablation system.The blood pressure data acquisition mechanism comprises a pressure sensor, a first valve, a second valve and a fluid passage, and the opening and closing states of the first valve and the second valve are opposite; one end of the first valve is connected with the fluid passage, the other end of the first valve is used for being connected with a filling pump, and when the first valve is in an open state and the second valve is in a closed state, the filling pump is communicated with the fluid passage so as to provide perfusate for the fluid passage; the pressure sensor is connected with the fluid channel through the second valve, and when the second valve is opened and the first valve is in a closed state, the pressure sensor is communicated with the fluid channel so as to collect blood pressure data in a blood vessel where the target spot is located. According to the invention, the blood pressure data in the blood vessel can be accurately obtained while the injury in the operation process is reduced, so that a good foundation is laid for realizing targeted ablation.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a blood pressure data acquisition mechanism, electronic equipment, a medical catheter and an ablation system. Background Art

[0002] Overactive nerves can have adverse effects on human organs or tissues, leading to a series of cardiovascular diseases. For example, chronic overactivation of the sympathetic nerves can cause excessive secretion of renin, increased sodium ion reabsorption by the kidneys, increased cardiac output and ultimately increased blood pressure. If this vicious cycle is not controlled, it will eventually lead to high-risk cardiovascular events such as heart failure and stroke.

[0003] At present, a method of treating hypertension by performing radiofrequency ablation on the renal artery through a radiofrequency ablation catheter has been proposed, namely, renal sympathetic denervation or RDN (renal denervation, percutaneous renal denervation) surgery. This surgery blocks the sympathetic nervous system around the renal artery through radiofrequency heating, reduces the sympathetic nerve tension, and thus achieves a long-term therapeutic effect of lowering blood pressure. Its principle can be simply summarized in two aspects: (i) by inhibiting the activity of sympathetic afferent nerve fibers, it can inhibit the overexcited sympathetic system of the whole body, thereby inhibiting abnormal vascular contraction, inhibiting abnormal heart rate increase and ultimately achieving the effect of controlling blood pressure; (ii) on the other hand, by inhibiting the activity of renal sympathetic efferent nerves, it can inhibit the excessive release of renin, thereby weakening the effect of the renin-angiotensin-aldosterone system on abnormal increase in systemic blood pressure.

[0004] Among them, RDN surgery is to reach the bilateral renal arteries through the femoral artery through a catheter, and release radiofrequency, ultrasound or microwave energy in the selected area by controlling the catheter to generate local high temperature in the renal artery intima to block the conduction function of some sympathetic nerve fibers on the renal artery wall. At present, RDN surgical treatment still faces a major challenge. Although the clinical results of the second-generation RDN have consistently shown that surgery can significantly reduce patients' blood pressure, in all clinical studies, a small number of patients in the surgical group have experienced an increase in blood pressure instead of a decrease. With the development of RDN surgery in recent years, the development of basic research in the field has gradually revealed the reasons for this phenomenon: (i) Insufficient sympathetic denervation. Almost all studies have shown that only blocking a certain proportion of sympathetic nerves can achieve the effect of lowering blood pressure; (ii) Parasympathetic denervation. In recent years, more and more basic studies have identified evidence of parasympathetic denervation around the renal artery through different methods. Due to the mutual checks and balances between parasympathetic denervation and sympathetic nerves, blind ablation of parasympathetic nerves will cause the originally suppressed sympathetic nerves to gain a dominant role, thereby worsening the symptoms of hypertensive patients.

[0005] During RDN surgery, the energy output at a fixed position causes changes in blood pressure, and its characteristics in some aspects are positively correlated with the types of nerves and their distribution around that position. Therefore, the characteristics of blood pressure changes at the energy output position can be used to judge the types of nerves and their distribution around that position, thereby achieving targeted ablation.

[0006] Therefore, it is particularly important to provide a solution for accurately obtaining blood pressure (blood flow pressure) data in blood vessels (such as renal arteries).

[0007] It should be noted that the information disclosed in the background technology section of the invention is only intended to deepen the understanding of the general background technology of the invention, and should not be regarded as an admission or suggestion in any form that the information constitutes prior art already known to those skilled in the art. Summary of the invention

[0008] The purpose of the present invention is to provide a blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system, which can accurately obtain blood pressure data in blood vessels while reducing damage during surgery, thereby laying a good foundation for achieving targeted ablation.

[0009] To achieve the above-mentioned purpose, the present invention provides a blood pressure data acquisition mechanism, which includes a pressure sensor, a first valve, a second valve and a fluid passage, wherein the switching state of the first valve is opposite to the switching state of the second valve; one end of the first valve is connected to the fluid passage, and the other end of the first valve is used to be connected to a perfusion pump, when the first valve is in an open state and the second valve is in a closed state, the perfusion pump is connected to the fluid passage to provide perfusion fluid to the fluid passage, and the fluid passage can transport the perfusion fluid to a target target point; the pressure sensor is connected to the fluid passage through the second valve, and when the second valve is open and the first valve is in a closed state, the pressure sensor is connected to the fluid passage to collect blood pressure data in the blood vessel where the target target point is located.

[0010] Optionally, the second valve is a three-way valve, and when the second valve is in a closed state, the pressure sensor is connected to the outside atmosphere.

[0011] Optionally, the first valve includes a first knob, a first valve body, and a first valve core located in the first valve body, the first valve core is connected to the first knob, and the first knob can drive the first valve core to rotate to control the switching state of the first valve; the second valve includes a second knob, a second valve body, and a second valve core located in the second valve body, the second valve core is connected to the second knob, and the second knob can drive the second valve core to rotate to control the switching state of the second valve.

[0012] Optionally, the blood pressure data acquisition mechanism also includes a rotating handle, which includes a rotating rod and a third knob connected to one end of the rotating rod, the first knob and the second knob are both engaged with the third knob, and the third knob can drive the first knob and the second knob to rotate to open one of the first valve and the second valve and close the other of the first valve and the second valve.

[0013] Optionally, the rotating handle also includes a handle portion connected to the other end of the rotating rod.

[0014] To achieve the above object, the present invention further provides an electronic device, the electronic device comprising a processor and a memory, the memory storing a computer program, and when the computer program is executed by the processor, the following steps are implemented:

[0015] Acquiring blood pressure data of the target point before and during stimulation, wherein the blood pressure data is acquired by the blood pressure data acquisition mechanism described in any one of the above items;

[0016] Drawing a blood pressure baseline according to the blood pressure data before the target point is stimulated;

[0017] A blood pressure change trend line is drawn based on the blood pressure data during the stimulation of the target point.

[0018] Optionally, drawing a blood pressure baseline according to the blood pressure data before the target point is stimulated includes:

[0019] Acquiring systolic blood pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0020] According to the systolic blood pressure data before the target point is stimulated, a baseline systolic blood pressure value is obtained;

[0021] Draw a systolic blood pressure baseline based on the baseline systolic blood pressure value; or

[0022] Acquiring diastolic pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0023] Obtaining a baseline diastolic blood pressure value according to the diastolic blood pressure data before the target point is stimulated;

[0024] Based on the baseline diastolic blood pressure value, a diastolic blood pressure baseline is plotted.

[0025] Optionally, drawing a blood pressure change trend line according to the blood pressure data during the stimulation of the target point includes:

[0026] Acquiring systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0027] Performing polynomial regression on the systolic blood pressure data during the stimulation of the target point;

[0028] Draw a systolic blood pressure change trend line according to the result of polynomial regression of the systolic blood pressure data during the stimulation of the target point; or

[0029] Acquiring diastolic pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0030] Performing polynomial regression on the diastolic pressure data during the stimulation of the target point;

[0031] According to the result of the polynomial regression of the diastolic pressure data during the stimulation of the target point, a diastolic pressure change trend line is drawn.

[0032] Optionally, obtain systolic blood pressure data by following these steps:

[0033] Dividing the blood pressure data into a plurality of blood pressure data segments according to a preset time window;

[0034] For each of the blood pressure data segments:

[0035] Find out all peak blood pressures in the blood pressure data segment;

[0036] For each peak blood pressure in this blood pressure data segment:

[0037] Finding the left boundary blood pressure and the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment;

[0038] Finding in the blood pressure data segment a first minimum blood pressure between the peak blood pressure and its left boundary blood pressure, and a second minimum blood pressure between the peak blood pressure and its right boundary blood pressure;

[0039] Calculating the left protrusion of the peak blood pressure according to the difference between the peak blood pressure and the first minimum blood pressure;

[0040] Calculating the right protrusion of the peak blood pressure according to the difference between the peak blood pressure and the second minimum blood pressure;

[0041] According to the left protrusion and the right protrusion of the peak blood pressure, whether the peak blood pressure is the systolic blood pressure is determined;

[0042] Based on all of the systolic blood pressures, systolic blood pressure data is obtained.

[0043] Optionally, searching for the left boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0044] Determining whether there is at least one peak blood pressure in the blood pressure data segment located on the left side of the peak blood pressure;

[0045] If not, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure corresponding to the peak blood pressure;

[0046] If so, the peak blood pressures located on the left side of the peak blood pressure are traversed one by one in the blood pressure data segment from right to left until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the left boundary blood pressure corresponding to the peak blood pressure.

[0047] Optionally, searching for the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0048] Determining whether there is at least one peak blood pressure in the blood pressure data segment located on the right side of the peak blood pressure;

[0049] If not, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure corresponding to the peak blood pressure;

[0050] If so, the peak blood pressures located on the right side of the peak blood pressure are traversed one by one in the blood pressure data segment from left to right until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the right boundary blood pressure corresponding to the peak blood pressure.

[0051] Optionally, judging whether the peak blood pressure is systolic pressure according to the left protrusion and the right protrusion of the peak blood pressure includes:

[0052] If the smaller one of the left protrusion and the right protrusion of the peak blood pressure is greater than a preset protrusion threshold, the peak blood pressure is determined to be systolic pressure.

[0053] Optionally, when the computer program is executed by a processor, the following steps are further implemented:

[0054] According to the blood pressure change trend line during the stimulation of the target point, the peak blood pressure and the trough blood pressure during the stimulation of the target point are obtained.

[0055] To achieve the above object, the present invention also provides a medical catheter, which includes a catheter body and a blood pressure data acquisition mechanism as described above, wherein the fluid passage is arranged in the catheter body and the fluid passage extends along the axial direction of the catheter body.

[0056] Optionally, the medical catheter further comprises a handle connected to the proximal end of the catheter body, and the pressure sensor, the first valve and the second valve are all disposed in the handle.

[0057] To achieve the above object, the present invention further provides an ablation system, which includes the electronic device described in any one of the above items or the medical catheter described in any one of the above items.

[0058] Compared with the prior art, the blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system provided by the present invention have the following beneficial effects:

[0059] The blood pressure data acquisition mechanism provided by the present invention includes a pressure sensor, a first valve, a second valve and a fluid passage, wherein the switch state of the first valve is opposite to the switch state of the second valve; one end of the first valve is connected to the fluid passage, and the other end of the first valve is used to connect to a perfusion pump, and when the first valve is in an open state and the second valve is in a closed state, the perfusion pump is connected to the fluid passage to provide perfusion fluid to the fluid passage, and the fluid passage can transport the perfusion fluid to the target target point; the pressure sensor is connected to the fluid passage through the second valve, and when the second valve is opened and the first valve is in a closed state, the pressure sensor is connected to the fluid passage to collect the blood pressure data in the blood vessel where the target target point is located. Since the fluid has the function of pressure transmission, when the second valve is opened and the first valve is in a closed state, the pressure in the blood vessel will be transmitted to the pressure sensor through the liquid (perfusion fluid) in the fluid passage, so that the blood pressure data in the blood vessel can be collected. Since the present invention utilizes a connected pressure sensor and a fluid path to realize the collection of blood pressure data, the number of puncture positions that the patient needs to undergo during the operation can be reduced, and the blood pressure data in the blood vessels can be accurately obtained while reducing the damage during the operation, so as to lay a good foundation for achieving targeted ablation. In addition, since the blood pressure data collection mechanism provided by the present invention can ensure that the collection position of the blood pressure data is closer to the target target (energy interference position), the accuracy of the acquired blood pressure data can be effectively guaranteed.

[0060] Since the electronic device, medical catheter and ablation system provided by the present invention belong to the same inventive concept as the blood pressure data acquisition mechanism provided by the present invention, the electronic device, medical catheter and ablation system provided by the present invention at least have all the beneficial effects of the blood pressure data acquisition mechanism provided by the present invention. Therefore, the relevant content about the beneficial effects of the electronic device, medical catheter and ablation system provided by the present invention can refer to the relevant description of the beneficial effects of the blood pressure data acquisition mechanism provided by the present invention in the above text, and will not be repeated here one by one. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] Figure 1 A schematic diagram of the overall structure of a blood pressure data acquisition mechanism provided by one embodiment of the present invention;

[0062] Figure 2 A schematic diagram of a blood pressure data acquisition mechanism provided by an embodiment of the present invention when the first valve is in an open state and the second valve is in a closed state;

[0063] Figure 3 A schematic diagram of a blood pressure data acquisition mechanism provided by an embodiment of the present invention when the first valve is in a closed state and the second valve is open;

[0064] Figure 4 A schematic diagram of the connection relationship between the rotating handle and the first valve and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention;

[0065] Figure 5 A schematic diagram of the state switching between the first valve and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention;

[0066] Figure 6 A schematic diagram of the cross-sectional structure of a medical catheter provided in one embodiment of the present invention;

[0067] Figure 7 A schematic diagram of a block structure of an electronic device provided in one embodiment of the present invention;

[0068] Figure 8 A schematic diagram of the steps that can be implemented by the electronic device provided by the present invention;

[0069] Fig. 9 A schematic diagram of blood pressure changes before and after stimulation energy intervention provided in a specific example of the present invention;

[0070] Fig.10 A blood pressure variation curve diagram within a single cardiac cycle provided for a specific example of the present invention;

[0071] Fig.11 A schematic diagram of a systolic blood pressure determination process according to an embodiment of the present invention;

[0072] Fig.12a A schematic diagram of protrusion calculation provided for a specific example of the present invention;

[0073] Figure 12b A schematic diagram of protrusion calculation provided for another specific example of the present invention;

[0074] Fig.13 A schematic diagram of the block structure of an ablation system provided in one embodiment of the present invention.

[0075] The reference numerals are described as follows:

[0076] Medical catheter-1000; catheter body-1200; electrical signal path-1210; guide wire-1211; pull wire path-1220; handle-1300;

[0077] Pressure sensor 1110; first valve 1120; first knob 1121; first valve body 1122; first valve core 1123; second valve 1130; second knob 1131; second valve body 1132; second valve core 1133; fluid passage 1140; rotating handle 1150; rotating rod 1151; third knob 1152; handle 1153;

[0078] Equipment components - 2000;

[0079] Electronic device-2100; processor-2110; communication interface-2120; memory-2130; communication bus-2140;

[0080] Energy output device-2200;

[0081] Irrigation pump-3000;

[0082] Vascular - 4000;

[0083] Original blood pressure change curve - 12; blood pressure baseline - 13; systolic blood pressure change trend line - 14; trough blood pressure - 15; peak blood pressure - 16; peak blood pressure - 17a, 17b, 17c. DETAILED DESCRIPTION

[0084] The blood pressure data acquisition mechanism, electronic device, medical catheter and ablation system proposed in the present invention are further described in detail below in conjunction with the accompanying drawings and specific embodiments. According to the following description, the advantages and features of the present invention will be clearer. It should be noted that the drawings are in a very simplified form and use non-precise proportions, which are only used to conveniently and clearly assist in explaining the purpose provided by the present invention. In order to make the purposes, features and advantages of the present invention more obvious and easy to understand, please refer to the accompanying drawings. It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the present invention. Any structural modification, change in proportional relationship or adjustment of size, under the condition of being the same or similar to the effects that can be produced by the present invention and the purposes that can be achieved, should still fall within the scope of the technical content disclosed by the present invention.

[0085] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or device including the elements. The singular forms "a", "an" and "the" include plural objects, the term "or" is generally used in a sense including "and / or", the term "several" is generally used in a sense including "at least one", and the term "at least two" is generally used in a sense including "two or more". In addition, the terms "first", "second" and "third" are used for descriptive purposes only and are not to be understood as indicating or suggesting relative importance or implicitly indicating the number of the indicated technical features.

[0086] In addition, in the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0087] The core idea of ​​the present invention is to provide a blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system, which can accurately obtain blood pressure data in blood vessels while reducing damage during surgery, thereby laying a good foundation for achieving targeted ablation.

[0088] It should be noted that the blood pressure data acquisition mechanism provided by the present invention can be applied to the medical catheter provided by the present invention, and the electronic device and the medical catheter provided by the present invention can be applied to the ablation system provided by the present invention. The electronic device can be integrated with the energy output device in the ablation system, or can be independently provided separately from the energy output device. It should also be noted that, as can be understood by those skilled in the art, the "proximal end" referred to in the present invention refers to the end close to the operator, that is, the end away from the target. In addition, it should be noted that the "blood vessel" referred to in the present invention can be, but is not limited to, blood vessels such as the renal artery and the pulmonary artery.

[0089] To realize the above idea, the present invention provides a blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system, please refer to Figures 1 to 3 ,in, Figure 1 A schematic diagram of the overall structure of a blood pressure data acquisition mechanism provided by one embodiment of the present invention; Figure 2 A schematic diagram of a blood pressure data acquisition mechanism provided by an embodiment of the present invention when the first valve is in an open state and the second valve is in a closed state; Figure 3 This is a schematic diagram of a blood pressure data acquisition mechanism provided by one embodiment of the present invention when the first valve is in a closed state and the second valve is open. Figures 1 to 3As shown, the blood pressure data acquisition mechanism includes a pressure sensor 1110, a first valve 1120, a second valve 1130 and a fluid passage 1140. The on / off state of the first valve 1120 is opposite to the on / off state of the second valve 1130. One end of the first valve 1120 is connected to the fluid passage 1140, and the other end of the first valve 1120 is used to connect to the perfusion pump 3000. When the first valve 1120 is in an open state and the second valve 1130 is in a closed state, the perfusion pump 3000 000 is connected to the fluid pathway 1140 to provide perfusion fluid to the fluid pathway 1140, and the fluid pathway 1140 can transport the perfusion fluid to the target target point; the pressure sensor 1110 is connected to the fluid pathway 1140 through the second valve 1130, and when the second valve 1130 is opened and the first valve 1120 is in a closed state, the pressure sensor 1110 is connected to the fluid pathway 1140 to collect blood pressure data in the blood vessel 4000 where the target target point is located.

[0090] Since the fluid has the function of transmitting pressure, when the second valve 1130 is opened and the first valve 1120 is in a closed state, the pressure in the blood vessel 4000 will be transmitted to the pressure sensor 1110 through the liquid (perfusion fluid) in the fluid passage 1140, so that the blood pressure data in the blood vessel 4000 can be collected. Since the present invention uses the connected pressure sensor 1110 and the fluid passage 1140 to realize the collection of blood pressure data, the number of puncture positions that the patient needs to accept during the operation can be reduced, and the blood pressure data in the blood vessel 4000 can be accurately obtained while reducing the damage during the operation, so as to lay a good foundation for achieving targeted ablation. In addition, since the blood pressure data collection mechanism provided by the present invention can ensure that the collection position of the blood pressure data is closer to the target target (energy interference position), the accuracy of the acquired blood pressure data can be effectively guaranteed.

[0091] Please continue to refer to Figure 2 and Figure 3 ,like Figure 2 and Figure 3 As shown, in some exemplary embodiments, the first valve 1120 is a common valve (two-way valve), the second valve 1130 is a three-way valve, and when the second valve 1130 is in a closed state, the pressure sensor 1110 is connected to the outside atmosphere. Therefore, by setting the second valve 1130 as a three-way valve, and when the second valve 1130 is in a closed state, the pressure sensor 1110 can be connected to the outside atmosphere, so that the pressure sensor 1110 can be calibrated by the standard atmospheric pressure, so that the accuracy of the blood pressure data collected by the pressure sensor 1110 can be further guaranteed.

[0092] Specifically, Figure 2 As shown, when the first valve 1120 is in an open state and the second valve 1130 is in a closed state, the perfusion pump 3000 is connected to the blood vessel 4000 through the fluid passage 1140 and isolated from the pressure sensor 1110. At this time, the perfusion fluid (e.g., saline) can enter the blood vessel 4000 through the fluid passage 1140 under the action of the perfusion pump 3000, thereby realizing the perfusion function of the perfusion fluid (e.g., saline). At the same time, the pressure sensor 1110 can be connected to the atmosphere through the second valve 1130, so that the pressure sensor 1110 can be calibrated by the standard atmospheric pressure. Figure 3 As shown, when the first valve 1120 is in a closed state and the second valve 1130 is in an open state, the pressure sensor 1110 is connected to the blood vessel 4000 through the fluid path 1140 and isolated from the atmosphere and the perfusion pump 3000, and the pressure in the blood vessel 4000 is transmitted to the pressure sensor 1110 through the perfusion fluid (e.g., saline). The pressure sensor 1110 converts the pressure change of the blood pressure into a voltage change (e.g., each +1 mmHg pressure change will result in a +5 μV output voltage change), and transmits it to the electronic device 2100 described below via the wire 1211 in the electrical signal path 1210 described below, and the electronic device 2100 then converts the received voltage change into a pressure change of the blood pressure.

[0093] It should be noted that, as can be understood by those skilled in the art, the state of the second valve 1130 when connecting the pressure sensor 1110 and the fluid passage 1140 is referred to as an open state, and the state of the second valve 1130 when connecting the pressure sensor 1110 and the outside atmosphere is referred to as a closed state.

[0094] Please continue to refer to Figures 1 to 3 ,like Figures 1 to 3 As shown, the first valve 1120 includes a first knob 1121, a first valve body 1122, and a first valve core 1123 located in the first valve body 1122. The first valve core 1123 is connected to the first knob 1121, and the first knob 1121 can drive the first valve core 1123 to rotate to control the on / off state of the first valve 1120. Thus, the operator can rotate the first knob 1121 to drive the first valve core 1123 to rotate, so as to connect or disconnect two connection ports (not shown in the figure, one of which is connected to the perfusion pump 3000, and the other is connected to the fluid passage 1140) on the first valve body 1122, thereby controlling the first valve 1120 to be opened or closed.

[0095] Please continue to refer to Figures 1 to 3,like Figures 1 to 3 As shown, in some exemplary embodiments, the second valve 1130 includes a second knob 1131, a second valve body 1132, and a second valve core 1133 located in the second valve body 1132, the second valve core 1133 is connected to the second knob 1131, and the second knob 1131 can drive the second valve core 1133 to rotate to control the on / off state of the second valve 1130. Thus, the operator can rotate the second knob 1131 to drive the second valve core 1133 to rotate, thereby controlling the second valve 1130 to open or close.

[0096] Specifically, when the second valve 1130 is a three-way valve, a first interface, a second interface and a third interface are provided on the second valve body 1132, wherein the first interface is connected to the pressure sensor 1110, the second interface is connected to the fluid passage 1140, and the third interface is connected to the outside atmosphere. When the second knob 1131 drives the second valve core 1133 to rotate to a position where the first interface is connected to the second interface, the second valve 1130 is in an open state; when the second knob 1131 drives the second valve core 1133 to rotate to a position where the first interface is connected to the third interface, the second valve 1130 is in a closed state.

[0097] Please continue to refer to Figure 1 , Figure 4 and Figure 5 ,in, Figure 4 A schematic diagram of the connection relationship between the rotating handle and the first valve and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention; Figure 5 The state switching principle diagram of the first valve and the second valve in the blood pressure data acquisition mechanism provided in one embodiment of the present invention. Figure 1 , Figure 4 and Figure 5As shown, in some exemplary embodiments, the blood pressure data acquisition mechanism provided by the present invention also includes a rotating handle 1150, wherein the rotating handle 1150 includes a rotating rod 1151 and a third knob 1152 connected to one end of the rotating rod 1151, the first knob 1121 and the second knob 1131 are both engaged with the third knob 1152, and the third knob 1152 can drive the first knob 1121 and the second knob 1131 to rotate to open one of the first valve 1120 and the second valve 1130 and close the other of the first valve 1120 and the second valve 1130. Since the first knob 1121 and the second knob 1131 are both engaged with the third knob 1152 on the rotating handle 1150, when the operator rotates the rotating handle 1150, the first knob 1121 and the second knob 1131 can be driven to rotate in the opposite direction at the same time, thereby controlling the first valve 1120 to open / the second valve 1130 to close or controlling the first valve 1120 to close / the second valve 1130 to open. It can be seen that by setting the rotating handle 1150, the states of the first valve 1120 and the second valve 1130 can be switched simultaneously, which makes it easier to operate.

[0098] Specifically, Figure 4 and Figure 5 As shown, by rotating the rotating handle 1150 counterclockwise, the first valve 1120 can be turned from Figure 4 The open state shown switches to Figure 5 The closed state shown in FIG. Figure 4 The closed state shown switches to Figure 5 Shown in open state.

[0099] Please continue to refer to Figure 1 ,like Figure 1 As shown, in some exemplary embodiments, the rotating handle 1150 further includes a handle portion 1153 connected to the other end of the rotating rod 1151. Thus, the operator can rotate the handle portion 1153 to drive the rotating rod 1151 and the third knob 1152 to rotate, thereby more conveniently driving the first knob 1121 and the second knob 1131 to rotate in the opposite direction.

[0100] It should be noted that, as can be understood by those skilled in the art, in some other embodiments, the first valve 1120 and the second valve 1130 may also be solenoid valves. In this case, there is no need to set the rotating handle 1150 and the first valve 1120 may no longer be provided with the first knob 1121, and the second valve 1130 may no longer be provided with the second knob 1131. Instead, the switching states of the first valve 1120 and the second valve 1130 are controlled by powering on and off.

[0101] Based on the same inventive concept, the present invention also provides a medical catheter, please refer to Figure 6 , which is a schematic diagram of the cross-sectional structure of a medical catheter provided by one embodiment of the present invention. Figure 6 As shown, the medical catheter 1000 includes a catheter body 1200 and the blood pressure data acquisition mechanism described in any one of the above items, and the fluid passage 1140 is arranged in the catheter body 1200, and the fluid passage 1140 is arranged to extend along the axial direction of the catheter body 1200. Since the medical catheter 1000 provided by the present invention includes the blood pressure data acquisition mechanism provided by the present invention, the medical catheter 1000 provided by the present invention can reduce the number of puncture positions that the patient needs to accept during the operation, and thus can accurately obtain the blood pressure data in the blood vessel 4000 while reducing the damage during the operation, so as to lay a good foundation for achieving targeted ablation. In addition, the medical catheter 1000 provided by the present invention can ensure that the collection position of the blood pressure data is closer to the target target (energy interference position), so as to effectively ensure the accuracy of the acquired blood pressure data.

[0102] In some exemplary embodiments, the medical catheter 1000 further includes a handle 1300 connected to the proximal end of the catheter body 1200, and the pressure sensor 1110, the first valve 1120, and the second valve 1130 are all disposed on the handle 1300 (see Figure 1 Thus, by arranging the pressure sensor 1110, the first valve 1120 and the second valve 1130 in the handle 1300 of the medical catheter 1000, the internal space of the handle 1300 can be fully utilized, thereby effectively simplifying the overall structure of the medical catheter 1000.

[0103] It should be noted that, as can be understood by those skilled in the art, one of the interfaces (the third interface) of the second valve 1130 can be connected to the outside atmosphere through a gas pipeline, one end of the gas pipeline connected to the second valve 1130 is located inside the handle 1300, and the other end of the gas pipeline extends to the outside of the handle 1300.

[0104] Please continue to refer to Figure 6 ,like Figure 6 As shown, in some exemplary embodiments, the medical catheter 1000 further includes an electrical signal path 1210 extending along the axial direction of the catheter body 1200, and the electrical signal path 1210 and the fluid path 1140 are isolated from each other. Thus, by providing the electrical signal path 1210 isolated from the fluid path 1140 on the catheter body 1200, a wire 1211 for transmitting an electrical signal can be arranged in the electrical signal path 1210, which not only facilitates wiring, but also prevents the wire 1211 from contacting the liquid in the fluid path 1140, thereby effectively improving the safety of the medical catheter 1000 during use.

[0105] Please continue to refer to Figure 6 ,like Figure 6 As shown, in some exemplary embodiments, the medical catheter 1000 further includes a wire passage 1220 extending along the axial direction of the catheter body 1200. Thus, the wire can be arranged in the wire passage 1220, so that the adjustable bending function of the catheter body 1200 can be achieved by manipulating the wire, thereby improving the maneuverability of the catheter body 1200.

[0106] It should be noted that, as those skilled in the art can understand, when the space of the catheter body 1200 is sufficient, two mutually isolated fluid passages 1140 can be provided on the catheter body 1200, thereby simultaneously obtaining the pressures at two different positions in the blood vessel 4000. It should also be noted that, as those skilled in the art can understand, more structures of the medical catheter 1000 can be adaptively understood by referring to the relevant contents in the field of ablation catheters known to those skilled in the art, and will not be described in detail here.

[0107] Based on the same inventive concept, the present invention also provides an electronic device, please refer to Figure 7 and Figure 8 ,in, Figure 7 A schematic diagram of a block structure of an electronic device provided in one embodiment of the present invention; Figure 8 Schematic diagram of the steps that can be implemented by the electronic device provided by the present invention. Figure 7 and Figure 8 As shown, the electronic device 2100 includes a processor 2110 and a memory 2130. The memory 2130 stores a computer program. When the computer program is executed by the processor 2110, the following steps are implemented:

[0108] Step S100: Obtaining blood pressure data of the target point before and during stimulation.

[0109] Step S200: Draw a blood pressure baseline 13 based on the blood pressure data of the target point before being stimulated.

[0110] Step S300: Draw a blood pressure change trend line based on the blood pressure data during the stimulation of the target point.

[0111] Wherein, the blood pressure data is collected by the blood pressure data collection mechanism described above.

[0112] Since the blood pressure data is collected by adopting the blood pressure data collection mechanism provided by the present invention, the accuracy of the acquired blood pressure data can be effectively guaranteed, and thus the accuracy of the blood pressure baseline 13 drawn based on the blood pressure data before the target target is stimulated and the blood pressure change trend line drawn based on the blood pressure data during the stimulation of the target target can be guaranteed, thereby providing a basis for accurately judging whether the target target is an ablation target, laying a good foundation for achieving targeted ablation, and thus effectively reducing the difficulty of the ablation surgery and shortening the operation time.

[0113] It should be noted that although Figure 8 The example of first executing step S100, then executing step S200, and finally executing step S300 is used for explanation, but as those skilled in the art can understand, this does not constitute a limitation of the present invention. In some other embodiments, step S200 may be executed immediately after obtaining the blood pressure data of the target point before being stimulated, or after executing step S100, step S200 and step S300 may be executed simultaneously.

[0114] In some exemplary embodiments, the step S200: drawing a blood pressure baseline 13 according to the blood pressure data of the target point before being stimulated, comprises:

[0115] Acquiring systolic blood pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0116] According to the systolic blood pressure data before the target point is stimulated, a baseline systolic blood pressure value is obtained;

[0117] Based on the baseline systolic blood pressure value, a systolic blood pressure baseline is plotted.

[0118] Specifically, the systolic blood pressure data of the target point before being stimulated can be obtained based on the blood pressure data within a preset time period before the target point is stimulated (for example, within 10 seconds before being stimulated), and then the baseline systolic blood pressure value can be obtained based on the average of the systolic blood pressure data before the target point is stimulated. The systolic blood pressure baseline (such as Fig. 9 As shown, Fig. 9A schematic diagram of blood pressure changes before and after stimulation energy intervention is provided for a specific example of the present invention, where 12 in the figure represents the original blood pressure change curve).

[0119] In some exemplary embodiments, the step S300: drawing a blood pressure change trend line according to the blood pressure data during the stimulation of the target point, includes:

[0120] Acquiring systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0121] Performing polynomial regression on the systolic blood pressure data during the stimulation of the target point;

[0122] A systolic blood pressure change trend line 14 is drawn according to the result of the polynomial regression of the systolic blood pressure data during the stimulation of the target point.

[0123] Thus, by first obtaining the systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point, and then performing polynomial regression on the systolic blood pressure data during the stimulation of the target point, a continuously changing and smoother systolic blood pressure change trend line 14 (such as Fig. 9 As shown), the influence of extreme systolic pressure on systolic pressure change trend line 14 is avoided, and the interference of data fluctuation on subsequent ablation target judgment is reduced.

[0124] Specifically, polynomial regression can be performed on the systolic blood pressure data during the stimulation of the target point according to the following formula (1):

[0125] sbp=f(t)=w n ×t n +w n-1 ×t n-1 +…+w1×t+w0×b (1)

[0126] Where sbp represents systolic / diastolic blood pressure, t is the stimulation time, w0, w1, ..., w n-1 、w n Represents the weight of each class, and b is a constant term.

[0127] Furthermore, the degree n of the polynomial is determined by the number m of systolic pressure (i.e., how many cardiac cycles have been experienced during the stimulation energy output process, i.e., during the stimulation process of the target point). Specifically, the degree n of the polynomial can be determined according to the following formula (2):

[0128]

[0129] In the formula, int means rounding.

[0130] It should be noted that, since the blood pressure in a single stimulation energy interference process (single stimulation process) generally does not fluctuate (change in direction) more than three times, the maximum value of the degree n of the polynomial is limited to no more than 4.

[0131] Furthermore, the weights w0, w1, ..., w of each class in the polynomial can be determined according to the following formula (3): n-1 、w n :

[0132]

[0133] Where:

[0134]

[0135] Among them, (t1,y1), (t2,y2), …, (t m ,y m ), which are respectively the collection time of m groups of systolic blood pressure and their corresponding pressure values ​​during the stimulation of the target point.

[0136] The w0, w1, ..., w calculated based on formula (3) are n-1 、w m By substituting the weights of each class into the above formula (1), the relationship between systolic pressure and time in the energy interference process can be obtained, and the systolic pressure change trend line 14 can be drawn based on the relationship.

[0137] It should be noted that the specific process of the polynomial regression in the present invention is similar to the traditional linear regression, and both are iterative calculation processes based on minimizing the difference between the actual value and the expected value. For more information on how to perform polynomial regression on the systolic blood pressure data during the stimulation of the target point, please refer to the relevant content in the field of polynomial regression known to those skilled in the art, and will not be described in detail here.

[0138] It should also be noted that, as can be understood by those skilled in the art, in some other embodiments, the systolic blood pressure change trend line 14 may also be drawn in the form of a moving average. Specifically, the systolic blood pressure change trend line 14 is drawn from the first systolic blood pressure after the stimulation energy intervention starts (stimulation starts, t=0s) to the next 10 systolic blood pressures (SBP1 to SBP 1+9 ), (SBP2 to SBP 2+9 ) ..., and so on, respectively calculate their average values, and connect them to obtain the systolic blood pressure change trend line 14. However, the method of drawing the systolic blood pressure change trend line 14 by using the moving average (Moving Average) method is easily affected by extreme systolic blood pressure.

[0139] Furthermore, in the prior art, a detection algorithm is generally used to identify the highest blood pressure (systolic blood pressure) within a single cardiac cycle. Currently, there are a large number of algorithms for implementing such functions, and their basic principles are mostly similar, that is, by selecting the time when the slope changes to determine the peak value (e.g., bp i ≥bp i-1 And bp i ≥bp i+1 , then the signal level at time i can be defined as the peak value, that is, the blood pressure at time i can be defined as the systolic pressure). However, in actual applications, multiple peaks may appear in a single cardiac cycle, for example, Fig.10 As shown ( Fig.10 The blood pressure change curve diagram within a single cardiac cycle provided for a specific example of the present invention shows that both blood pressure 17a and blood pressure 17b meet the conditions for being peak blood pressure, but only blood pressure 17a correctly represents the systolic blood pressure level within the cardiac cycle, and blood pressure 17b can only represent the peak value within a local range.

[0140] Commonly used methods for identifying global peaks within a cycle (such as Fig.10 The blood pressure in 17a) and the local peak value (such as Fig.10 The method of measuring the blood pressure in 17b) includes: 1. directly setting the value range of the peak; 2. specifying the minimum spacing between two peaks; 3. setting the frequency of the peaks that appear within a fixed time; 4. the duration of the peaks, etc. Since the actual situation has the phenomenon of large fluctuations in blood pressure and heart rate, it is inappropriate to directly specify the value range, minimum spacing and frequency of the peaks. And since there is no significant difference in the duration of the local peak and the global peak, the method of determining the systolic blood pressure based on the duration of the peak is also inappropriate.

[0141] In order to solve the above problem, in some exemplary embodiments, the present invention obtains systolic blood pressure data through the following steps:

[0142] Dividing the blood pressure data into a plurality of blood pressure data segments according to a preset time window;

[0143] For each of the blood pressure data segments:

[0144] Find out all peak blood pressures in the blood pressure data segment;

[0145] For each peak blood pressure in this blood pressure data segment:

[0146] Finding the left boundary blood pressure and the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment;

[0147] Finding in the blood pressure data segment a first minimum blood pressure between the peak blood pressure and its left boundary blood pressure, and a second minimum blood pressure between the peak blood pressure and its right boundary blood pressure;

[0148] Calculating the left protrusion of the peak blood pressure according to the difference between the peak blood pressure and the first minimum blood pressure;

[0149] Calculating the right protrusion of the peak blood pressure according to the difference between the peak blood pressure and the second minimum blood pressure;

[0150] According to the left protrusion and the right protrusion of the peak blood pressure, whether the peak blood pressure is the systolic blood pressure is determined;

[0151] Based on all of the systolic blood pressures, systolic blood pressure data is obtained.

[0152] Therefore, the present invention can effectively avoid misjudgment of systolic pressure caused by local peak value in a single cardiac cycle by judging whether the peak blood pressure is systolic pressure according to the prominence of the peak blood pressure, and effectively improve the accuracy of the acquired systolic pressure data.

[0153] It should be noted that, as can be understood by those skilled in the art, the method of determining the peak value by selecting the time when the slope change occurs as described above can be used to find all the peak blood pressures in each blood pressure data segment. In addition, it should be noted that, as can be understood by those skilled in the art, the duration of the preset time window can be set according to actual needs, but the duration of the preset time window should be greater than one cardiac cycle. For example, the duration of the preset time window can be set to 2.5s, and the duration of each blood pressure data segment is 2.5s.

[0154] In some exemplary implementations, searching for the left boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0155] Determining whether there is at least one peak blood pressure in the blood pressure data segment located on the left side of the peak blood pressure;

[0156] If not, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure corresponding to the peak blood pressure;

[0157] If so, the peak blood pressures located on the left side of the peak blood pressure are traversed one by one in the blood pressure data segment from right to left until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the left boundary blood pressure corresponding to the peak blood pressure.

[0158] Therefore, by taking the peak blood pressure that is greater than or equal to the peak blood pressure and located on the left side of the peak blood pressure as the left boundary blood pressure corresponding to the peak blood pressure, misjudgment of the local peak in a single cardiac cycle can be further avoided.

[0159] It should be noted that if all peak blood pressures on the left side of the peak blood pressure in the blood pressure data segment are lower than the peak blood pressure, the first blood pressure in the blood pressure data segment will also be used as the left boundary blood pressure corresponding to the peak blood pressure.

[0160] In some exemplary implementations, searching for the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes:

[0161] Determining whether there is at least one peak blood pressure in the blood pressure data segment located on the right side of the peak blood pressure;

[0162] If not, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure corresponding to the peak blood pressure;

[0163] If so, the peak blood pressures located on the right side of the peak blood pressure are traversed one by one in the blood pressure data segment from left to right until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the right boundary blood pressure corresponding to the peak blood pressure.

[0164] Therefore, by taking the peak blood pressure that is greater than or equal to the peak blood pressure and located on the right side of the peak blood pressure as the right boundary blood pressure corresponding to the peak blood pressure, misjudgment of the local peak in a single cardiac cycle can be further avoided.

[0165] It should be noted that if all peak blood pressures on the right side of the peak blood pressure in the blood pressure data segment are lower than the peak blood pressure, the last blood pressure in the blood pressure data segment will also be used as the right boundary blood pressure corresponding to the peak blood pressure.

[0166] In some exemplary embodiments, judging whether the peak blood pressure is systolic pressure according to the left protrusion and the right protrusion of the peak blood pressure includes:

[0167] If the smaller one of the left protrusion and the right protrusion of the peak blood pressure is greater than a preset protrusion threshold, the peak blood pressure is determined to be systolic pressure.

[0168] Specifically, when the smaller of the left protrusion and the right protrusion of the peak blood pressure is greater than the preset protrusion threshold, it indicates that the protrusions on both sides of the peak blood pressure are close to the overall amplitude of the blood pressure signal, so the peak blood pressure can be determined as systolic pressure. When the smaller of the left protrusion and the right protrusion of the peak blood pressure is less than or equal to the preset protrusion threshold, it indicates that the protrusion on one side of the peak blood pressure is smaller than the overall amplitude of the blood pressure signal, so the peak blood pressure can be determined as a local peak blood pressure, and the peak blood pressure will not be determined as systolic pressure.

[0169] It should be noted that the protrusion threshold can be set according to the overall amplitude of the blood pressure signal, and the present invention does not limit the specific value of the protrusion threshold.

[0170] Please continue to refer to Fig.11 , which is a schematic diagram of a systolic blood pressure determination process provided by one embodiment of the present invention. Fig.11 As shown, for each blood pressure data segment, first, find out all the peak blood pressures in the blood pressure data segment. Then, starting from i=1, the other peak blood pressures (blood pressures other than the i-th peak blood pressure) located on the right side of the i-th peak blood pressure are traversed one by one in the blood pressure data segment from left to right, until the other peak blood pressures currently traversed are greater than or equal to the i-th peak blood pressure, then the other peak blood pressures currently traversed are used as the right side boundary blood pressure j corresponding to the i-th peak blood pressure. Similarly, the other peak blood pressures located on the left side of the i-th peak blood pressure are traversed one by one in the blood pressure data segment from right to left, until the other peak blood pressures currently traversed are greater than or equal to the i-th peak blood pressure, then the other peak blood pressures currently traversed are used as the left side boundary blood pressure k corresponding to the i-th peak blood pressure. Furthermore, if there is no other peak blood pressure on the right side of the ith peak blood pressure or there is no other peak blood pressure greater than or equal to the ith peak blood pressure, the last blood pressure in the blood pressure data segment is used as the right side boundary blood pressure j of the ith peak blood pressure; if there is no other peak blood pressure on the left side of the ith peak blood pressure or there is no other peak blood pressure greater than or equal to the ith peak blood pressure, the first blood pressure in the blood pressure data segment is used as the left side boundary blood pressure k of the ith peak blood pressure. After determining the right side boundary blood pressure j and the left side boundary blood pressure k of the ith peak blood pressure, the right side protrusion of the ith peak blood pressure is calculated according to the following formula (4), and the left side protrusion of the ith peak blood pressure is calculated according to the following formula (5):

[0171] P right =Amplitude i -min(Amplitude i:j ) (4)

[0172] P left=Amplitude i -min(Amplitude k:i ) (5)

[0173] Where P right is the right protrusion of the ith peak blood pressure, P left Amplitude is the left protrusion of the ith peak blood pressure. i is the ith peak blood pressure, min(Amplitude i:j ) is the minimum blood pressure (i.e., the second minimum blood pressure) between the i-th peak blood pressure and its right boundary blood pressure j in the blood pressure data segment, min(Amplitude k:i ) is the minimum blood pressure (i.e., the first minimum blood pressure) between the i-th peak blood pressure and its left boundary blood pressure k in the blood pressure data segment.

[0174] After calculating the right protrusion P of the i-th peak blood pressure right and left protrusion P left Then, the right protrusion P right and left protrusion P left The smaller one of the above is taken as the prominence P of the i-th peak blood pressure. i (That is, P i =min(P right , P left )). If the prominence of the i-th peak blood pressure P i Greater than the preset protrusion threshold P threshold (i.e. P i >P threshold ), the i-th peak blood pressure is determined as the global peak blood pressure, that is, the i-th peak blood pressure is determined as the systolic pressure; otherwise, the i-th peak blood pressure is determined as the local peak blood pressure (non-systolic pressure).

[0175] Please continue to refer to Fig.12a and Figure 12b ,in, Fig.12a A schematic diagram of protrusion calculation provided for a specific example of the present invention; Figure 12b A schematic diagram of the protrusion calculation principle provided for another specific example of the present invention. For the peak blood pressure 17a, since it is greater than the peak blood pressure 17b, the right boundary blood pressure j will be calculated according to Fig.11 The determination process shown in FIG is extended to the next peak blood pressure 17c which is greater than the peak blood pressure 17a. Since there is no other peak blood pressure on its left side, the first blood pressure in the blood pressure data segment in which the peak blood pressure is located is taken as its left boundary blood pressure k. Based on its right boundary blood pressure j and left boundary blood pressure k, the left protrusion degree P of the peak blood pressure 17a can be calculated. left and the right protrusion P right (like Fig.12aAs shown in the figure, both are close to the overall amplitude of the blood pressure signal, so the peak blood pressure 17a can be used as the systolic pressure. On the other hand, since the peak blood pressure 17b is smaller than the peak blood pressures 17a and 17c on both sides, the peak blood pressure 17a can be used as its left boundary blood pressure k, and the peak blood pressure 17c can be used as its right boundary blood pressure j. Based on its right boundary blood pressure j and left boundary blood pressure k, the left protrusion P of the peak blood pressure 17b can be calculated. left and the right protrusion P right (like Figure 12b As shown), due to the left protrusion P of the peak blood pressure 17b left Smaller than the right protrusion P right And the left protrusion P left Compared with the overall amplitude of the blood pressure signal, the peak blood pressure 17b is smaller, so the peak blood pressure 17b is determined to be the local peak blood pressure rather than the systolic pressure.

[0176] In some exemplary embodiments, when the computer program is executed by a processor, the following steps are further implemented:

[0177] According to the blood pressure change trend line during the stimulation of the target point, the peak blood pressure 16 and the trough blood pressure 15 during the stimulation of the target point are obtained.

[0178] Therefore, by obtaining the peak blood pressure 16 and trough blood pressure 15 during the stimulation of the target target point based on the blood pressure change trend line during the stimulation of the target target point, the operator can accurately determine whether the target target point is an ablation target point based on the peak blood pressure 16 and trough blood pressure 15 during the stimulation of the target target point.

[0179] It should be noted that, as can be understood by those skilled in the art, the peak blood pressure 16 refers to the highest blood pressure on the blood pressure change trend line, and the trough blood pressure 15 refers to the lowest blood pressure on the blood pressure change trend line.

[0180] In some other exemplary embodiments, the step S200: drawing the blood pressure baseline 13 according to the blood pressure data of the target point before being stimulated, includes:

[0181] Acquiring diastolic pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated;

[0182] Obtaining a baseline diastolic blood pressure value according to the diastolic blood pressure data before the target point is stimulated;

[0183] Based on the baseline diastolic blood pressure value, a diastolic blood pressure baseline is plotted.

[0184] Specifically, the diastolic pressure data of the target point before stimulation can be obtained based on the blood pressure data within a preset time period before the target point is stimulated (for example, within 10 seconds before stimulation), and then the baseline diastolic pressure value can be obtained based on the average of the diastolic pressure data of the target point before stimulation, and the diastolic pressure baseline can be drawn based on the baseline diastolic pressure value.

[0185] It should be noted that, as can be understood by those skilled in the art, the identification of diastolic pressure can adopt a logic similar to that of systolic pressure, and the specific content of the steps for obtaining systolic pressure data can be referred to above for adaptive understanding, which will not be described in detail here. In addition, a simpler identification method can also be adopted: that is, when the systolic pressure has been identified, the minimum blood pressure between two adjacent systolic pressures is the diastolic pressure.

[0186] In some other exemplary embodiments, the step S300: drawing a blood pressure change trend line according to the blood pressure data during the stimulation of the target point, includes:

[0187] Acquiring diastolic pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point;

[0188] Performing polynomial regression on the diastolic pressure data during the stimulation of the target point;

[0189] According to the result of the polynomial regression of the diastolic pressure data during the stimulation of the target point, a diastolic pressure change trend line is drawn.

[0190] Therefore, by first obtaining the diastolic pressure data of the target target during the stimulation process based on the blood pressure data of the target target during the stimulation process, and then performing polynomial regression on the diastolic pressure data of the target target during the stimulation process, a continuously changing and smoother diastolic pressure change trend line can be drawn according to the result of the polynomial regression, thereby avoiding the influence of extreme diastolic pressure on the diastolic pressure change trend line and reducing the interference of data fluctuations on subsequent ablation target judgment.

[0191] It should be noted that, as can be understood by those skilled in the art, the specific content of how to perform polynomial regression on the diastolic pressure data can be adaptively understood by referring to the relevant content above on how to perform polynomial regression on the systolic pressure data, and will not be elaborated here.

[0192] It should also be noted that, as can be understood by those skilled in the art, in some other embodiments, the diastolic pressure change trend line can also be drawn by using a moving average (MovingAverage) method. Specifically, starting from the first diastolic pressure after the stimulation energy interference starts (start of stimulation, t=0s) to the next 10 diastolic pressures... and so on, their average values ​​are calculated respectively and connected to obtain the diastolic pressure change trend line.

[0193] Please continue to refer to Figure 8 ,like Figure 8 As shown, the electronic device 2100 also includes a communication interface 2120 and a communication bus 2140, wherein the processor 2110, the communication interface 2120, and the memory 2130 communicate with each other through the communication bus 2140. The communication bus 2140 can be a peripheral component interconnect standard (PCI) bus or an extended industry standard architecture (EISA) bus. The communication bus 2140 can be divided into an address bus, a data bus, a control bus, etc. For ease of representation, only one thick line is used in the figure, but it does not mean that there is only one bus or one type of bus. The communication interface 2120 is used for communication between the above-mentioned electronic device 2100 and other devices.

[0194] The processor 2110 referred to in the present invention may be a central processing unit (CPU), or other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA) or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or any conventional processor, etc. The processor 2110 is the control center of the electronic device 2100, and various interfaces and lines are used to connect various parts of the entire electronic device 2100.

[0195] The memory 2130 may be used to store the computer program, and the processor 2110 implements various functions of the electronic device 2100 by running or executing the computer program stored in the memory 2130 and calling the data stored in the memory 2130 .

[0196] The memory 2130 may include non-volatile and / or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable memory (PROM), electrically programmable memory (EPROM), electrically erasable programmable memory (EEPROM) or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. As an illustration and not limitation, random access memory is available in many forms, such as static random access memory (SRAM), dynamic random access memory (DRAM), synchronous random access memory (SDRAM), double data rate synchronous random access memory (DDRSDRAM), enhanced synchronous random access memory (ESDRAM), synchronous link (Synchlink) dynamic random access memory (SLDRAM), memory bus (Rambus) direct random access memory (RDRAM), direct memory bus dynamic random access memory (DRDRAM), and memory bus dynamic random access memory (RDRAM).

[0197] Based on the same inventive concept, the present invention further provides an ablation system, the ablation system comprising the electronic device 2100 and / or the medical catheter 1000 described above. Since the ablation system provided by the present invention comprises the electronic device 2100 and / or the medical catheter 1000 provided by the present invention, the ablation system provided by the present invention at least has all the beneficial effects of the electronic device 2100 and / or the medical catheter 1000 provided by the present invention, and the relevant descriptions of the beneficial effects of the electronic device 2100 and / or the medical catheter 1000 provided by the present invention can be referred to above, and will not be repeated here one by one.

[0198] Please continue to refer to Fig.13 , which is a schematic diagram of the block structure of an ablation system provided by one embodiment of the present invention. Fig.13 As shown, in some exemplary embodiments, the ablation system further includes an energy output device 2200 electrically connected to the electronic device 2100 and the medical catheter 1000, and the energy output device 2200 is configured to provide stimulation energy or ablation energy to the medical catheter 1000 to stimulate or ablate the target.

[0199] Specifically, taking the renal artery as an example, the connection between the device assembly 2000 composed of the electronic device 2100 and the energy output device 2200, the medical catheter 1000 and the human body can be described as the device assembly 2000 outputting ablative and / or non-ablative interference (stimulation) energy to the medical catheter 1000, and the medical catheter 1000 entering the body through unilateral femoral artery puncture to transfer the energy to the blood vessel wall in the renal artery through the metal wire 1211 in the electrical signal path 1210. The impedance and temperature (thermocouple signal) of the blood vessel wall tissue are also fed back to the device assembly 2000 through the metal wire 1211 in the electrical signal path 1210 of the medical catheter 1000. The connection between the perfusion pump 3000, the medical catheter 1000 and the human body can be described as the perfusion pump 3000 uniformly pumping physiological saline into the medical catheter 1000, and the medical catheter 1000 entering the body through unilateral femoral artery puncture to transfer the physiological saline to the renal artery through the fluid path 1140. By switching the connection between the perfusion pump 3000, the fluid pathway 1140 and the human body to the connection between the pressure sensor 1110, the fluid pathway 1140 and the human body, the pressure changes in the blood vessel 4000 can be transmitted to the pressure sensor 1110 through the liquid (e.g., saline) in the fluid pathway 1140, thereby obtaining a dynamic waveform of the real-time pressure changes in the blood vessel 4000. The pressure sensor 1110 can convert the pressure changes in the blood pressure into voltage changes (e.g., every +1 mmHg pressure change will result in a +5 μV output voltage change), and send it to the electronic device 2100. The electronic device 2100 can directly obtain the blood pressure data through the original digital signal (voltage change) fed back by the pressure sensor 1110 and the established conversion relationship (e.g., every +1 mmHg pressure change will result in a +5 μV output voltage change).

[0200] It should be noted that, as can be understood by those skilled in the art, the stimulation energy or ablation energy provided by the energy output device 2200 may be, but is not limited to, radio frequency energy, pulse energy, ultrasonic energy, etc.

[0201] In summary, compared with the prior art, the blood pressure data acquisition mechanism, electronic equipment, medical catheter and ablation system provided by the present invention have the following beneficial effects:

[0202] (1) The present invention collects blood pressure data by using the connected pressure sensor 1110 and fluid passage 1140, thereby reducing the number of puncture positions that the patient needs to undergo during the operation, and accurately obtaining blood pressure data in the blood vessel 4000 while reducing the damage during the operation, so as to lay a good foundation for achieving targeted ablation. In addition, since the blood pressure data collection mechanism provided by the present invention can ensure that the blood pressure data collection position is closer to the target target (energy interference position), the accuracy of the obtained blood pressure data can be effectively guaranteed.

[0203] (2) The present invention performs polynomial regression on the systolic blood pressure data / diastolic blood pressure data during the stimulation of the target point, thereby being able to draw a continuously changing and smoother systolic blood pressure change trend line 14 / diastolic blood pressure change trend line, thereby avoiding the influence of extreme systolic blood pressure / diastolic blood pressure on the systolic blood pressure change trend line 14 / diastolic blood pressure change trend line, and reducing the interference of data fluctuations on subsequent ablation target judgment.

[0204] (3) The present invention can effectively avoid misjudgment of systolic pressure caused by a local peak value in a single cardiac cycle by determining whether the peak blood pressure is systolic pressure based on the prominence of the peak blood pressure, thereby effectively improving the accuracy of the acquired systolic pressure data.

[0205] It should be noted that the computer program code for performing the operation of the present invention can be written in one or more programming languages ​​or a combination thereof, including object-oriented programming languages-such as Java, Smalltalk, C++, and also conventional procedural programming languages-such as "C" language or similar programming languages. The program code can be executed entirely on the user's computer, partially on the user's computer, as an independent software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the case of a remote computer, the remote computer can be connected to the user's computer through any type of network-including a local area network (LAN) or a wide area network (WAN), or can be connected to an external computer (for example, using an Internet service provider to connect through the Internet).

[0206] It should be noted that the devices and methods disclosed in the embodiments of this article can also be implemented in other ways. The device embodiments described above are merely schematic. For example, the flowcharts and block diagrams in the accompanying drawings show the possible architecture, functions and operations of the devices, methods and computer program products according to the multiple embodiments of this article. In this regard, each box in the flowchart or block diagram can represent a module, a part of a program or a code, and the module, a part of a program segment or a code contains one or more executable instructions for implementing the specified logical function. It should also be noted that in some alternative implementations, the functions marked in the box can also occur in a different order from the order marked in the accompanying drawings. For example, two consecutive boxes can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or the flowchart, and the combination of boxes in the block diagram and / or the flowchart, can be implemented by a dedicated hardware-based system for performing a specified function or action, or can be implemented by a combination of dedicated hardware and computer instructions. In addition, the functional modules in the various embodiments of this document may be integrated together to form an independent part, or each module may exist independently, or two or more modules may be integrated to form an independent part.

[0207] It should also be noted that the above description is only a description of the preferred embodiment of the present invention, and is not any limitation on the scope of the present invention. Any changes and modifications made by a person skilled in the art in the field of the present invention based on the above disclosure are within the scope of protection of the present invention. Obviously, a person skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations fall within the scope of the present invention and its equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A blood pressure data collection mechanism, characterized in that: The device comprises a pressure sensor, a first valve, a second valve and a fluid passage, wherein the switch state of the first valve is opposite to the switch state of the second valve; One end of the first valve is connected to the fluid passage, and the other end of the first valve is used to be connected to a perfusion pump. When the first valve is in an open state and the second valve is in a closed state, the perfusion pump is connected to the fluid passage to provide perfusion fluid to the fluid passage, and the fluid passage can transport the perfusion fluid to the target point; The pressure sensor is connected to the fluid path through the second valve. When the second valve is opened and the first valve is in a closed state, the pressure sensor is connected to the fluid path to collect blood pressure data in the blood vessel where the target point is located.

2. The blood pressure data acquisition mechanism according to claim 1, characterized in that: The second valve is a three-way valve. When the second valve is in a closed state, the pressure sensor is connected to the outside atmosphere.

3. The blood pressure data acquisition mechanism according to claim 1, characterized in that: The first valve comprises a first knob, a first valve body and a first valve core located in the first valve body, the first valve core is connected to the first knob, and the first knob can drive the first valve core to rotate to control the on / off state of the first valve; The second valve includes a second knob, a second valve body, and a second valve core located in the second valve body. The second valve core is connected to the second knob. The second knob can drive the second valve core to rotate to control the switching state of the second valve.

4. The blood pressure data acquisition mechanism according to claim 3, characterized in that: It also includes a rotating handle, which includes a rotating rod and a third knob connected to one end of the rotating rod, the first knob and the second knob are both engaged with the third knob, and the third knob can drive the first knob and the second knob to rotate to open one of the first valve and the second valve and close the other of the first valve and the second valve.

5. The blood pressure data acquisition mechanism according to claim 4, characterized in that: The rotating handle also includes a handle portion connected to the other end of the rotating rod.

6. An electronic device, characterized in that: The system comprises a processor and a memory, wherein a computer program is stored in the memory, and when the computer program is executed by the processor, the following steps are implemented: Acquiring blood pressure data of the target point before and during stimulation, wherein the blood pressure data is acquired by the blood pressure data acquisition mechanism according to any one of claims 1 to 5; Drawing a blood pressure baseline according to the blood pressure data before the target point is stimulated; A blood pressure change trend line is drawn based on the blood pressure data during the stimulation of the target point.

7. The electronic device according to claim 6, characterized in that: Drawing a blood pressure baseline according to the blood pressure data before the target point is stimulated includes: Acquiring systolic blood pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated; According to the systolic blood pressure data before the target point is stimulated, a baseline systolic blood pressure value is obtained; Draw a systolic blood pressure baseline based on the baseline systolic blood pressure value; or Acquiring diastolic pressure data of the target point before being stimulated according to the blood pressure data of the target point before being stimulated; Obtaining a baseline diastolic blood pressure value according to the diastolic blood pressure data before the target point is stimulated; Based on the baseline diastolic blood pressure value, a diastolic blood pressure baseline is plotted.

8. The electronic device according to claim 6, characterized in that: Drawing a blood pressure change trend line according to the blood pressure data during the stimulation of the target point includes: Acquiring systolic blood pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point; Performing polynomial regression on the systolic blood pressure data during the stimulation of the target point; Draw a systolic blood pressure change trend line according to the result of polynomial regression of the systolic blood pressure data during the stimulation of the target point; or Acquiring diastolic pressure data during the stimulation of the target point according to the blood pressure data during the stimulation of the target point; Performing polynomial regression on the diastolic pressure data during the stimulation of the target point; According to the result of the polynomial regression of the diastolic pressure data during the stimulation of the target point, a diastolic pressure change trend line is drawn.

9. The electronic device according to claim 7 or 8, characterized in that: To obtain systolic blood pressure data, follow these steps: Dividing the blood pressure data into a plurality of blood pressure data segments according to a preset time window; For each of the blood pressure data segments: Find out all peak blood pressures in the blood pressure data segment; For each peak blood pressure in this blood pressure data segment: Finding the left boundary blood pressure and the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment; Finding in the blood pressure data segment a first minimum blood pressure between the peak blood pressure and its left boundary blood pressure, and a second minimum blood pressure between the peak blood pressure and its right boundary blood pressure; Calculating the left protrusion of the peak blood pressure according to the difference between the peak blood pressure and the first minimum blood pressure; Calculating the right protrusion of the peak blood pressure according to the difference between the peak blood pressure and the second minimum blood pressure; According to the left protrusion and the right protrusion of the peak blood pressure, whether the peak blood pressure is the systolic blood pressure is determined; Based on all of the systolic blood pressures, systolic blood pressure data is obtained.

10. The electronic device according to claim 9, characterized in that: The step of searching for the left boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes: Determining whether there is at least one peak blood pressure in the blood pressure data segment located on the left side of the peak blood pressure; If not, the first blood pressure in the blood pressure data segment is used as the left boundary blood pressure corresponding to the peak blood pressure; If so, the peak blood pressures located on the left side of the peak blood pressure are traversed one by one in the blood pressure data segment from right to left until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the left boundary blood pressure corresponding to the peak blood pressure.

11. The electronic device according to claim 9, characterized in that: The step of searching for the right boundary blood pressure corresponding to the peak blood pressure in the blood pressure data segment includes: Determining whether there is at least one peak blood pressure in the blood pressure data segment located on the right side of the peak blood pressure; If not, the last blood pressure in the blood pressure data segment is used as the right boundary blood pressure corresponding to the peak blood pressure; If so, the peak blood pressures located on the right side of the peak blood pressure are traversed one by one in the blood pressure data segment from left to right until the currently traversed peak blood pressure is greater than or equal to the peak blood pressure. The currently traversed peak blood pressure is then used as the right boundary blood pressure corresponding to the peak blood pressure.

12. The electronic device according to claim 9, characterized in that: The step of judging whether the peak blood pressure is systolic pressure according to the left protrusion and the right protrusion of the peak blood pressure includes: If the smaller one of the left protrusion and the right protrusion of the peak blood pressure is greater than a preset protrusion threshold, the peak blood pressure is determined to be systolic pressure.

13. The electronic device according to claim 6, characterized in that: When the computer program is executed by a processor, the following steps are also implemented: According to the blood pressure change trend line during the stimulation of the target point, the peak blood pressure and the trough blood pressure during the stimulation of the target point are obtained.

14. A medical catheter, characterized in that: The invention comprises a catheter body and the blood pressure data acquisition mechanism according to any one of claims 1 to 5, wherein the fluid passage is arranged in the catheter body and the fluid passage is extended along the axial direction of the catheter body.

15. The medical catheter according to claim 14, characterized in that It also includes a handle connected to the proximal end of the catheter body, and the pressure sensor, the first valve and the second valve are all arranged in the handle.

16. An ablation system, characterized in that: An electronic device comprising any one of claims 6 to 13 or a medical catheter comprising claim 14 or 15.

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