Gingiva protecting and tooth whitening strip and preparation method thereof
By using gingival whitening teeth patches prepared with components such as acrylate copolymer gel-forming agents with excellent adhesion effect on teeth, the problem of peroxide whitening agents in existing whitening teeth patches irritating the residual gums and gel layer. Achieving gum protection and residue-free effects.
Patent Information
- Application Number
- CN202411648480.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-18
- Publication Date
- 2025-02-18
AI Technical Summary
The peroxide whitening agent in existing teeth whitening patches irritates the gums, and the gel layer is prone to remain on the tooth surface, affecting user experience and safety.
A gel is prepared by homogenizing the acrylate copolymer with excellent adhesion effect on teeth edges, combined with deionized water, whitening agent, pH adjuster, sweetener, desensitizer, stabilizer and fragrance agent. , and make gum whitening tooth patches through coating and baking.
It effectively avoids the irritation of peroxide whitening agents on the gums, and the tooth patch has excellent tear-free performance, which improves user experience and reduces safety risks.
Smart Images
Figure CN119454516A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of oral care technology, and in particular to a gum protection and whitening tooth patch and a preparation method thereof. Background Art
[0002] With the improvement of living standards, people pay more and more attention to the beauty of teeth. At present, there are a wide variety of teeth whitening products on the market, such as teeth whitening pens, whitening trays, whitening strips, etc., which can achieve teeth whitening effects and are very popular among consumers. In particular, whitening strips are not only effective in whitening teeth, but also easy to operate, low-priced, simple and practical, and are most favored by consumers.
[0003] Whitening tooth strips are composed of a film layer, an elastic gel layer and a backing layer. When in use, peel off the backing layer and stick the elastic gel layer on the tooth surface. The whitening ingredients contained in the gel layer, such as hydrogen peroxide, sodium percarbonate, urea peroxide, phthalimido peroxycaproic acid, etc., release active oxygen to oxidize and decompose the coloring substances on the tooth surface and / or in the tooth body, achieving a bleaching effect. However, the peroxide whitening ingredient will also irritate the gum tissue in the mouth, causing gum discomfort and even redness and swelling.
[0004] In addition, in order to adapt to the different shapes of tooth surfaces, the gel layer of whitening tooth strips must have sufficient flexibility and plasticity. In order to ensure that the tooth strips fit the tooth surface, most whitening tooth strips on the market usually use flexible gelling agents, such as polyvinyl alcohol, cellulose and polyvinyl pyrrolidone. Although flexible gelling agents are conducive to the tooth strips fitting the tooth surface, due to their low intrinsic film strength and poor stability, they are easy to break when the tooth strips are removed after whitening, resulting in the gel layer remaining on the tooth surface, which is commonly known as the "sticky teeth" phenomenon in the industry, affecting the user experience and posing a safety hazard. Summary of the invention
[0005] In order to solve the technical problems that the peroxide whitening agent components in existing whitening tooth strips irritate the gums and the gel layer easily remains on the tooth surface and affects the user experience, the present application provides a gum protecting whitening tooth strip and a preparation method thereof.
[0006] In order to achieve the above purpose, the technical solution of the embodiment of the present application is:
[0007] The first aspect of the present application provides a gum protection and whitening tooth patch, wherein the gum protection and whitening tooth patch comprises the following components in parts by weight:
[0008] Provided are 0.50-30.0 parts of an acrylic copolymer gelling agent having excellent tooth edge sealing effect, 10.0-50.0 parts of deionized water, 0.10-15.0 parts of a whitening agent, 0.010-2.0 parts of a pH adjusting agent, 0.010-0.30 parts of a sweetener, 0.010-5.0 parts of a desensitizing agent, 0.0010-0.10 parts of a stabilizer, and 0.050-1.50 parts of a flavoring agent.
[0009] In combination with the first aspect, preferably, the acrylic copolymer gelling agent having excellent tooth edge sealing effect is prepared by the following method:
[0010] 500.0 mol parts of deionized water, 6.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.15 mol parts of hexadecyltrimethylammonium bromide and 0.15 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and the mixture was mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 65-70° C. at a heating rate of 10° C. per minute, 0.050 mol parts of ammonium persulfate were added, and the mixture was mechanically stirred at a constant temperature of 65-70° C. for 1.0 hour. Then, 7.0 mol parts of acrylic acid, 5.50 mol parts of lauryl acrylate, 5.50 mol parts of dimethylaminoethyl methacrylate, 3.50 mol parts of ethyl acetoacetate, 6.20 mol parts of methyl methacrylate were dropwise added to the glass reactor. A mixed solution consisting of 0.050 mol of ammonium persulfate and 0.020 mol of ammonium persulfate was added, and the temperature of the glass reactor was raised to 80-85° C. at a heating rate of 10° C. per minute, and the temperature was kept at 80-85° C. for 3.0 hours with mechanical stirring, and the reaction was cooled to room temperature, filtered with a 200-mesh nylon cloth, and the material was discharged. The filtrate was washed with 300.0 mol of deionized water for 3 times (100.0 mol each time), and the filtrate was then vacuum dried at 60° C. for 48.0 hours to obtain the acrylic copolymer gelling agent with excellent tooth edge sealing effect.
[0011] In combination with the first aspect, preferably, the conductivity of the deionized water is lower than 0.01 μS / cm.
[0012] In combination with the first aspect, preferably, the whitening agent is one of carbamide peroxide, phthalimide peroxycaproic acid, sodium phytate or sodium hypochlorite.
[0013] In combination with the first aspect, preferably, the pH adjuster is one of sodium tripolyphosphate, dipotassium hydrogen phosphate or potassium dihydrogen phosphate.
[0014] In combination with the first aspect, preferably, the sweetener is a liquorice extract, which contains glycyrrhizic acid not less than 12%.
[0015] In combination with the first aspect, preferably, the desensitizing agent is one of potassium nitrate, strontium citrate or hydroxyapatite.
[0016] In combination with the first aspect, preferably, the stabilizer is one of ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate or tartaric acid.
[0017] In combination with the first aspect, preferably, the flavoring agent is one of menthol, mint flavor, floral flavor or fruity flavor.
[0018] The second aspect of the present application provides a method for preparing the gum protection and whitening tooth patch according to the first aspect, the preparation method comprising:
[0019] The acrylic copolymer gelling agent with excellent tooth edge sealing effect as claimed in claim 2, deionized water, whitening agent, pH regulator, sweetener, desensitizer, stabilizer and flavoring agent are mixed and then homogenized and emulsified to obtain a gel;
[0020] The gel is coated on the PET film substrate by coating, the adhesive is placed in a baking oven for baking, and then a PE soft film is covered on the surface of the gel by embossing to obtain the gum protection and whitening tooth patch.
[0021] Compared with the prior art, the advantages or beneficial effects of the embodiments of the present application include at least:
[0022] The acrylate copolymer gelling agent with excellent tooth edge sealing effect provided in the embodiment of the present application can not only seal the tooth edge well to avoid the damage of the peroxide whitening agent in the tooth paste to the gums, but also has excellent tensile strength and elongation at break, which can make the tooth paste have excellent easy-to-tear and residue-free performance. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] The drawings constituting part of the present application are used to provide a further understanding of the present application. The exemplary embodiments and descriptions of the present application are used to explain the present application and do not constitute an improper limitation on the present application. Among them:
[0024] Figure 1 The present invention provides a structural formula of an acrylic copolymer gelling agent with excellent tooth edge sealing effect. DETAILED DESCRIPTION
[0025] In order to make the purpose, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings. The described embodiments should not be regarded as limiting the present application. All other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of this application.
[0026] In the following description, reference is made to "some embodiments", which describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or different subsets of all possible embodiments, and may be combined with each other without conflict. Unless otherwise defined, all technical and scientific terms used in the embodiments of the present application have the same meaning as those commonly understood by those skilled in the art of the technical field of the embodiments of the present application. The terms used in the embodiments of the present application are only for the purpose of describing the embodiments of the present application and are not intended to limit the present application.
[0027] In the following description of this embodiment, the terms "include", "comprising", "having" and "containing" are all open terms, meaning including but not limited to.
[0028] It should be noted that all raw materials / reagents in the examples of this application can be purchased on the market.
[0029] Purchase or prepare according to conventional methods well known to those skilled in the art; the term "and / or" in the embodiments of the present application is only used to describe the association relationship of associated objects, indicating that there may be three relationships, for example, A and / or B means that A exists alone, B exists alone, and A and B exist at the same time, wherein A and B can be singular or plural, and the character " / " generally indicates that the associated objects before and after are in an "or" relationship.
[0030] In the following description of this embodiment, the term "at least one" refers to one or more, and "plurality" refers to two or more. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, "at least one of a, b or c", or "at least one of a, b and c", can all represent: a, b, c, ab (i.e., a and b), ac, bc, or abc, where a, b, c can be single or multiple, respectively.
[0031] Those skilled in the art should understand that in the following description of the embodiments of the present application, the order of serial numbers does not mean the order of execution, some or all of the steps can be executed in parallel or sequentially, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.
[0032] The terms used in the embodiments of the present application are only for the purpose of describing specific embodiments, and are not intended to limit the present application. The singular forms "a", "an" and "the" used in the embodiments of the present application and the appended claims are also intended to include plural forms, unless the context clearly indicates other meanings.
[0033] It should be understood by those skilled in the art that the numerical ranges in the examples of the present application should be understood to also specifically disclose each intermediate value between the upper and lower limits of the range.
[0034] Each smaller range between and intervening values in a stated range and any other stated value or intervening value in that stated range is encompassed within the application. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
[0035] Unless otherwise stated, the technical / scientific terms used herein have the same meanings as those generally understood by those skilled in the art in the field described in the present application. Although the present application only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the embodiments or test cases of the present application. All documents mentioned in this specification are generally incorporated by reference to disclose and describe the methods and / or materials related to the documents. In the event of a conflict with any incorporated document, the content of the present application shall prevail.
[0036] In a first aspect, an embodiment of the present application provides a gum protection and whitening tooth patch, which comprises the following components in parts by weight:
[0037] Provided are 0.50-30.0 parts of an acrylic copolymer gelling agent having excellent tooth edge sealing effect, 10.0-50.0 parts of deionized water, 0.10-15.0 parts of a whitening agent, 0.010-2.0 parts of a pH adjusting agent, 0.010-0.30 parts of a sweetener, 0.010-5.0 parts of a desensitizing agent, 0.0010-0.10 parts of a stabilizer, and 0.050-1.50 parts of a flavoring agent.
[0038] The acrylic copolymer gelling agent with excellent tooth edge sealing effect provided in the present application can not only seal the tooth edge well to avoid the damage of the peroxide whitening agent in the tooth paste to the gums, but also has excellent tensile strength and elongation at break, which can make the tooth paste have excellent easy-to-tear and residue-free performance.
[0039] In a specific embodiment, the acrylic copolymer gelling agent with excellent tooth edge sealing effect in the embodiment of the present application is prepared by the following method:
[0040] 500.0 mol parts of deionized water, 6.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.15 mol parts of hexadecyltrimethylammonium bromide and 0.15 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and the mixture was mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 65-70° C. at a heating rate of 10° C. per minute, 0.050 mol parts of ammonium persulfate were added, and the mixture was mechanically stirred at a constant temperature of 65-70° C. for 1.0 hour. Then, 7.0 mol parts of acrylic acid, 5.50 mol parts of lauryl acrylate, 5.50 mol parts of dimethylaminoethyl methacrylate, 3.50 mol parts of ethyl acetoacetate, 6.20 mol parts of methyl methacrylate were dropwise added to the glass reactor. A mixed solution consisting of 0.050 mol of ammonium persulfate and 0.020 mol of ammonium persulfate was added, and the temperature of the glass reactor was raised to 80-85° C. at a heating rate of 10° C. per minute, and the temperature was kept at 80-85° C. for 3.0 hours with mechanical stirring, and the reaction was cooled to room temperature, filtered with a 200-mesh nylon cloth, and the material was discharged. The filtrate was washed with 300.0 mol of deionized water for 3 times (100.0 mol each time), and the filtrate was then vacuum dried at 60° C. for 48.0 hours to obtain the acrylic copolymer gelling agent with excellent tooth edge sealing effect.
[0041] It should be noted that the structural formula of the acrylic copolymer gelling agent with excellent tooth edge adhesion effect is as follows Figure 1 shown.
[0042] In a specific embodiment, the conductivity of the deionized water in the embodiment of the present application is lower than 0.01 μS / cm.
[0043] It should be noted that the deionized water acts as a solvent to increase the solubility of the acrylate copolymer gelling agent with excellent tooth edge sealing effect, thereby ensuring that the acrylate copolymer gelling agent with excellent tooth edge sealing effect is completely dissolved.
[0044] In a specific embodiment, the whitening agent in the embodiment of the present application is one of urea peroxide, phthalimide peroxycaproic acid, sodium phytate or sodium hypochlorite.
[0045] It should be noted that whitening agents can whiten teeth by improving the whiteness of the tooth surface through physical stain removal and chemical oxidation.
[0046] In a specific embodiment, the pH adjuster in the embodiment of the present application is one of sodium tripolyphosphate, dipotassium hydrogen phosphate or potassium dihydrogen phosphate.
[0047] It should be noted that the pH adjuster plays a role in stabilizing the distribution of components, avoiding distribution changes between components due to surface segregation effects, which would affect the teeth whitening effect.
[0048] In a specific embodiment, the sweetener in the embodiment of the present application is licorice extract, and the glycyrrhizic acid content thereof is not less than 12%.
[0049] It should be noted that the sweetener serves to increase the sweetness of the gel layer and improve the user experience.
[0050] In a specific embodiment, the desensitizing agent in the embodiment of the present application is one of potassium nitrate, strontium citrate or hydroxyapatite.
[0051] It should be noted that desensitizing agents have a desensitizing effect to prevent users from experiencing allergic reactions.
[0052] In a specific embodiment, the stabilizer in the embodiment of the present application is one of ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid or tartaric acid.
[0053] It should be noted that the stabilizer plays the role of stabilizing the whitening agent to prevent the whitening agent from decomposing during storage, thereby affecting the whitening effect.
[0054] In a specific embodiment, the flavoring agent in the embodiment of the present application is one of menthol, mint flavor, floral flavor or fruity flavor.
[0055] It should be noted that the flavoring agent plays a role in regulating the flavor of the gel layer, providing users with more flavor options.
[0056] In a second aspect, the present application provides a method for preparing the gum protection and whitening tooth patch according to the first aspect, the preparation method comprising:
[0057] The acrylic copolymer gelling agent with excellent tooth edge sealing effect as claimed in claim 2, deionized water, whitening agent, pH regulator, sweetener, desensitizer, stabilizer and flavoring agent are mixed and then homogenized and emulsified to obtain a gel;
[0058] The gel is coated on the PET film substrate by coating, the adhesive is placed in a baking oven for baking, and then a PE soft film is covered on the surface of the gel by embossing to obtain the gum protection and whitening tooth patch.
[0059] It should be noted that 0.50-30.0 parts of an acrylic copolymer gelling agent with excellent tooth edge sealing effect, 10.0-50.0 parts of deionized water, 0.10-15.0 parts of a whitening agent, 0.010-2.0 parts of a pH adjuster, 0.010-0.30 parts of a sweetener, 0.010-5.0 parts of a desensitizing agent, 0.0010-0.10 parts of a stabilizer, and 0.050-1.50 parts of a flavoring agent are added into a vacuum homogenizing emulsifying pot, and the mixture is homogenized and emulsified at 25-30°C and 0.1 MPa for 2.0 hours to obtain a gel, and the gel is evenly coated on a PET film backing by a coating machine, and then the paste is placed in a baking oven at 60°C and baked for 0.5 hours, and then the PE soft film is embossed and covered on the surface of the gel layer by a three-roll calender to obtain the gum protection and whitening tooth patch.
[0060] The technical method of the present application will be further described below in conjunction with specific embodiments.
[0061] Example 1
[0062] This embodiment 1 provides a method for preparing a gum protection and whitening tooth patch 1, and the specific steps are as follows:
[0063] 1) Preparation of an acrylic copolymer gelling agent 1 having excellent tooth edge sealing effect: 500.0 mol parts of deionized water, 6.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.15 mol parts of hexadecyltrimethylammonium bromide and 0.15 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 65° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction was stirred mechanically at a constant temperature of 65° C. for 1.0 hour. Then, 7.0 mol parts of acrylic acid, 5.50 mol parts of lauryl acrylate, 5.50 mol parts of dimethylaminoethyl methacrylate, 3.50 mol parts of methyl methacrylate were added dropwise to the glass reactor. A mixed solution consisting of ethyl acetoacetate, 6.20 molar parts of 2-hydroxypropyl methacrylate and 0.30 molar parts of 4-hydroxybutyl acrylate was added within 1.0 hour, and then 0.050 molar parts of ammonium persulfate were added, and the mixture was reacted at a constant temperature of 65°C with mechanical stirring for 1.0 hour. Then 0.020 molar parts of ammonium persulfate were added, and the glass reactor was heated to 80°C at a heating rate of 10°C per minute, and the mixture was reacted at a constant temperature of 80°C with mechanical stirring for 3.0 hours, cooled to room temperature, filtered with a 200-mesh nylon cloth, and the material was discharged. The filtrate was washed with 300.0 molar parts of deionized water for 3 times, each time with 100.0 molar parts, and then the filtrate was vacuum dried at 60°C for 48.0 hours to obtain an acrylate copolymer gelling agent 1 with excellent tooth edge sealing effect.
[0064] 2) Preparation of gum protection and whitening tooth patch 1: 0.5 parts of an acrylic copolymer gelling agent 1 having excellent tooth edge sealing effect, 10.0 parts of deionized water, 0.10 parts of urea peroxide, 0.010 parts of sodium tripolyphosphate, 0.010 parts of licorice extract, 0.010 parts of potassium nitrate, 0.0010 parts of ethylenediaminetetraacetic acid, and 0.050 parts of menthol were added into a homogenizing and emulsifying pot, and homogenized and emulsified at 25° C. for 2.0 hours to obtain a gel, and the gel was evenly coated on a PET film backing by a coating machine, and then the patch was placed in a baking oven at 60° C. and baked for 0.5 hours, and then a PE soft film was embossed and covered on the surface of the gel layer by a three-roll calender to obtain a gum protection and whitening tooth patch 1.
[0065] Example 2
[0066] This embodiment 2 provides a method for preparing a gum protection and whitening tooth patch 2, and the specific steps are as follows:
[0067] 1) Preparation of acrylic copolymer gelling agent 2 with excellent tooth edge sealing effect: 500.0 mol parts of deionized water, 6.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.15 mol parts of hexadecyltrimethylammonium bromide and 0.15 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and mechanically stirred at room temperature for 0.50 hours. The glass reactor was heated to 70° C. at a heating rate of 10° C. per minute, and 0.050 mol parts of ammonium persulfate were added. The reaction was mechanically stirred at 70° C. for 1.0 hour, and then 7.0 mol parts of acrylic acid, 5.50 mol parts of lauryl acrylate, 5.50 mol parts of dimethylaminoethyl methacrylate, 3.50 mol parts of methyl methacrylate were added dropwise to the glass reactor. A mixed solution consisting of ethyl acetoacetate, 6.20 molar parts of 2-hydroxypropyl methacrylate and 0.30 molar parts of 4-hydroxybutyl acrylate was added within 1.0 hour, and then 0.050 molar parts of ammonium persulfate were added, and the mixture was reacted at a constant temperature of 70°C with mechanical stirring for 1.0 hour. Then 0.020 molar parts of ammonium persulfate were added, and the glass reactor was heated to 85°C at a heating rate of 10°C per minute, and the mixture was reacted at a constant temperature of 85°C with mechanical stirring for 3.0 hours, cooled to room temperature, filtered with a 200-mesh nylon cloth, and the material was discharged. The filtrate was washed with 300.0 molar parts of deionized water 3 times, each time with 100.0 molar parts, and then the filtrate was vacuum dried at 60°C for 48.0 hours to obtain an acrylate copolymer gelling agent 2 with excellent tooth edge sealing effect.
[0068] 2) Preparation of gum protection and whitening tooth patch 2: 30.0 parts of acrylic copolymer gelling agent 2 with excellent tooth edge sealing effect, 50.0 parts of deionized water, 15.0 parts of urea peroxide, 2.0 parts of sodium tripolyphosphate, 0.30 parts of licorice extract, 5.0 parts of potassium nitrate, 0.10 parts of ethylenediaminetetraacetic acid, and 1.50 parts of menthol are added into a homogenizing and emulsifying pot, and homogenized and emulsified at 30°C for 2.0 hours to obtain a gel, and the gel is evenly coated on a PET film backing by a coating machine, and then the patch is placed in a baking oven at 60°C and baked for 0.5 hours, and then a PE soft film is embossed and covered on the surface of the gel layer by a three-roll calender to obtain a gum protection and whitening tooth patch 2.
[0069] Comparative Example 1
[0070] This comparative example 1 provides a method for preparing a whitening tooth paste 3, and the specific steps are as follows:
[0071] 0.5 parts of polyvinyl alcohol film-forming agent with a viscosity of 70.0 mpas, 2.0 parts of polyvinyl pyrrolidone, 0.1 parts of sodium cellulose, 10.0 parts of medical alcohol, 10.0 parts of deionized water, 0.5 parts of glycerol, 0.1 parts of urea peroxide, 0.01 parts of sodium tripolyphosphate, 0.01 parts of sucralose, 0.01 parts of citric acid, 0.01 parts of potassium nitrate, 0.001 parts of ethylenediaminetetraacetic acid, and 0.05 parts of menthol were added into a vacuum homogenizing emulsifying pot, homogenized and emulsified at 25°C and 0.1 MPa for 2.0 hours to obtain a gel, and the gel was evenly coated on a PET film backing by a coating machine, and then the bond was placed in a baking oven at 60°C and baked for 3.0 hours, and then the PE soft film was embossed and covered on the surface of the gel layer by a three-roll calender to obtain a whitening tooth patch 3.
[0072] Comparative Example 2
[0073] This comparative example 2 provides a method for preparing a whitening tooth paste 4, and the specific steps are as follows:
[0074] 50.0 parts of polyvinyl pyrrolidone, 15.0 parts of sodium cellulose, 50.0 parts of medical alcohol, 50.0 parts of deionized water, 15.0 parts of glycerol, 15.0 parts of urea peroxide, 2.0 parts of sodium tripolyphosphate, 0.30 parts of sucralose, 0.40 parts of citric acid, 5.0 parts of potassium nitrate, 0.10 parts of ethylenediaminetetraacetic acid, and 1.50 parts of menthol were added into a vacuum homogenizing emulsifying pot, and homogenized and emulsified at 30°C and 0.1 MPa for 2.0 hours to obtain a gel, and the gel was evenly coated on a PET film backing by a coating machine, and then the patch was placed in a baking oven at 60°C and baked for 3.0 hours, and then the PE soft film was embossed and covered on the surface of the gel layer by a three-roll calender to obtain a whitening tooth patch 4.
[0075] Performance testing
[0076] Test 1: Gum protection performance test of tooth paste
[0077] The test conditions are as follows: Shandong Sairuite SRT-Z029 periodontal probe torque tester was used to test the gums of 50 healthy gum volunteers in each group after using the gum protection and whitening tooth paste. The tooth paste was used once every day from 9:00 to 9:30 and once every day from 15:00 to 15:30, for a total of 2 times a day. After 7 consecutive days of use, the periodontal probe test was performed. The test results are shown in Table 1.
[0078] Test 2: Tooth paste strength performance test
[0079] The experimental conditions are as follows: Shanghai Hengyi tensile and compression testing machine (HY-0580 (DB)) was used for measurement. At room temperature, the tooth paste sample with the bottom lining removed was clamped between the upper and lower clamps for tensile testing under set tensile conditions. The effective initial length between the clamps was 40 mm, and the speed of the clamp movement was 100 m / min. The tensile strength was determined based on the tensile tension at the final break and the size of the initial sample cross-section, that is, the tensile strength at the final break. The elongation at break is the maximum tensile length of the sample between the clamps minus the effective initial length of the sample between the clamps divided by the effective initial length of the sample between the clamps. The sample was tested 10 times and the average value was taken. The test results are shown in Table 1.
[0080] Test 3: Fracture of tooth paste after use
[0081] After the whitening tooth strips prepared in the above examples and comparative examples were removed from the backing, actual application tests were carried out respectively, the tooth strips were attached to the tooth surface, peeled off after 15 minutes, and whether there was a breakage residue was recorded. Each group of samples was tested 10 times and the average value was taken. The test results are shown in Table 1.
[0082] Test 4: Release rate of whitening ingredients from tooth strips
[0083] In an indoor environment at a temperature of 25°C, the whitening tooth strips were pasted on a glass slide and then immersed in a beaker filled with 1L of deionized water, with the glass slide parallel to the beaker wall. The changes in the peroxide concentration in the water were monitored from the time the sample was immersed, and the concentration was measured at 10min, 30min, and 1h using an RQflex reflectometer. After 1h, the whitening tooth strips were dissolved in ethyl acetate, and the dissolved tooth strips were added to a beaker filled with 1L of deionized water, stirred evenly, and the total concentration of the whitening component (peroxide) in the tooth strips was measured. At the same time, the concentration dissolution rate (the value of the peroxide concentration in the water as a percentage of the total concentration) at each measurement time point was calculated.
[0084] Test 5: Whitening effect test of tooth strips
[0085] Maxillary premolars extracted for orthodontic treatment within 30 days were selected, and the tooth surface color difference (L* value) was measured using a spectrocolorimeter. The teeth were then wrapped with whitening tape and immersed in a beaker containing 100 ml of deionized water, and then taken out after immersion at 37°C for 2.0 hours, and the tooth surface color difference (L* value) was measured using a spectrocolorimeter. The whitening effect was evaluated based on the change in L* value (△L) before and after immersion treatment.
[0086] The test results are shown in Table 1:
[0087] Table 1: Whitening strips performance test results
[0088]
[0089] The test results show that the number of people who experienced symptoms of gingival swelling, pain, bleeding, bad breath, and loose teeth in Examples 1-2 was significantly less than that in Comparative Examples 1-2, indicating that the tooth patch has an excellent gum protection effect. In addition, there was no broken residue in Examples 1-2 when peeled off, while there was broken residue in Comparative Example 1-2, and Comparative Example 2 had poor plasticity and poor adhesion to the tooth surface, which shows that the whitening tooth patch prepared in Example 1-2 has excellent residue-free performance. In addition, the dissolution rate of the whitening ingredients in Example 1-2 increased uniformly, indicating that the tooth patch has excellent continuous whitening performance. Finally, the whitening effect of the whitening tooth patch in Example 1-2 is significantly higher than that in Comparative Example 1-2.
[0090] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art who is familiar with the present technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.
Claims
1. A gum protection and whitening tooth patch, characterized in that: The whitening tooth paste comprises the following components in parts by weight: Provided are 0.50-30.0 parts of an acrylic copolymer gelling agent having excellent tooth edge sealing effect, 10.0-50.0 parts of deionized water, 0.10-15.0 parts of a whitening agent, 0.010-2.0 parts of a pH adjusting agent, 0.010-0.30 parts of a sweetener, 0.010-5.0 parts of a desensitizing agent, 0.0010-0.10 parts of a stabilizer, and 0.050-1.50 parts of a flavoring agent.
2. The gum protection and whitening tooth patch according to claim 1, characterized in that: The acrylic copolymer gelling agent with excellent tooth edge sealing effect is prepared by the following method: S1: 500.0 mol parts of deionized water, 6.0 mol parts of trimethylaminoethyl methacrylate chloride, 0.25 mol parts of OP-10, 0.15 mol parts of hexadecyltrimethylammonium bromide and 0.15 mol parts of isooctyl thioglycolate were added to a dry glass reactor in sequence, and mechanically stirred at room temperature for 0.50 hours; S2: heating the glass reactor to 65-70°C at a heating rate of 10°C per minute, adding 0.050 mol of ammonium persulfate, and reacting at a constant temperature of 65-70°C with mechanical stirring for 1.0 hour; S3: Into a glass reactor, a mixed solution consisting of 7.0 molar parts of acrylic acid, 5.50 molar parts of lauryl acrylate, 5.50 molar parts of dimethylaminoethyl methacrylate, 3.50 molar parts of ethyl acetoacetate methacrylate, 6.20 molar parts of 2-hydroxypropyl methacrylate and 0.30 molar parts of 4-hydroxybutyl acrylate was added dropwise, and the mixture was completed within 1.0 hour; S4: Add 0.050 mole of ammonium persulfate, keep the temperature at 65-70°C and mechanically stir to react for 1.0 hour, then add 0.020 mole of ammonium persulfate, heat the glass reactor to 80-85°C at a heating rate of 10°C per minute, keep the temperature at 80-85°C and mechanically stir to react for 3.0 hours, cool to room temperature, filter with 200-mesh nylon cloth, and discharge. S5: The filtrate is washed with 300.0 mol parts of deionized water three times, each time with 100.0 mol parts, and then the filtrate is vacuum dried at 60° C. for 48.0 hours. The filtrate after drying is collected as an acrylic copolymer gelling agent that can be closely fitted to the edge of the tooth.
3. The gum protection and whitening tooth patch according to claim 1, characterized in that: The conductivity of the deionized water is lower than 0.01 μS / cm.
4. The gum protection and whitening tooth patch according to claim 1, characterized in that: The whitening agent is one of carbamide peroxide, phthalimide peroxycaproic acid, sodium phytate or sodium hypochlorite.
5. The gum protection and whitening tooth patch according to claim 1, characterized in that: The pH regulator is one of sodium tripolyphosphate, dipotassium hydrogen phosphate or potassium dihydrogen phosphate.
6. The gum protection and whitening tooth patch according to claim 1, characterized in that: The sweetener is liquorice extract.
7. The gum protection and whitening tooth patch according to claim 1, characterized in that: The desensitizing agent is one of potassium nitrate, strontium citrate or hydroxyapatite.
8. The gum protection and whitening tooth patch according to claim 1, characterized in that: The stabilizer is one of ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetate or tartaric acid.
9. The gum protection and whitening tooth patch according to claim 1, characterized in that: The flavoring agent is one of menthol, mint essence, floral essence or fruity essence.
10. A method for preparing the gum protection and whitening tooth patch according to any one of claims 1 to 9, characterized in that: include: The acrylic copolymer gelling agent with excellent tooth edge sealing effect as claimed in claim 2, deionized water, whitening agent, pH regulator, sweetener, desensitizer, stabilizer and flavoring agent are mixed and then homogenized and emulsified to obtain a gel; The gel is coated on the PET backing film by coating, the patch is placed in a baking oven for baking, and then the PE soft film is covered on the surface of the gel by embossing to obtain the gum protection and whitening tooth patch.