Wound hemostasis and repair composite material and preparation method thereof

Abstract

The invention discloses a wound hemostasis and repair composite material and a preparation method thereof, and belongs to the technical field of medical materials, the wound hemostasis and repair composite material comprises the following raw materials in parts by weight: 10-20 parts of chitosan and 8-12 parts of water, the water is deionized water, and the wound hemostasis and repair composite material also comprises a spraying agent, and the spraying agent is one or a mixture of more of trichloromonofluoromethane, difluoromethane and trichlorotetrafluoroethane. The preparation method of the wound hemostasis and repair composite material comprises the following steps: step 1, weighing a specified amount of raw materials, then adding chitosan and water into stirring equipment, and then stirring to obtain a mixture; 2, performing high-pressure sterilization on the mixture; and step 3, after the high-pressure sterilization is completed, cooling to room temperature, checking, and quantitatively subpackaging after the checking is qualified. According to the wound hemostasis and repair composite material and the preparation method thereof, the product acts in a sterile mode, and wound infection is greatly reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of medical materials, and in particular relates to a wound hemostasis and repair composite material and a preparation method thereof. Background Art

[0002] Wounds refer to the damage to normal skin tissue caused by external factors, which brings inconvenience to people's lives and increases their mental stress. When wounds heal, they will also produce a certain amount of exudate, and ordinary wound treatment dressings have a general effect.

[0003] Therefore, in view of this situation, there is an urgent need to design and produce a wound hemostatic repair composite material and a preparation method thereof to meet actual needs. Summary of the invention

[0004] The purpose of the present invention is to provide a wound hemostasis and repair composite material and a preparation method thereof, so as to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solution: a wound hemostasis and repair composite material, comprising chitosan and water, wherein the weight mass proportions of each raw material are: 10-20 parts of chitosan and 8-12 parts of water.

[0006] Preferably, the water is set to be deionized water.

[0007] Preferably, the method further comprises a propellant, wherein the propellant is set to be one or a mixture of trichloromonofluoromethane, difluoromethane, trichlorotetrafluoroethane.

[0008] A method for preparing a wound hemostasis and repair composite material comprises the following steps:

[0009] Step 1, weighing a specified amount of raw materials, then adding chitosan and water into a stirring device, and then stirring to obtain a mixture;

[0010] Step 2: then sterilizing the mixture under high pressure;

[0011] Step 3: After the high pressure sterilization is completed, the mixture is cooled to room temperature and then inspected. After the inspection is qualified, it is quantitatively packaged to obtain a mixture of the same components;

[0012] Step 4: introduce the divided mixture into the spraying device, and then pressurize the spraying agent into the spraying device.

[0013] Preferably, the stirring time is set to 60-100 minutes, and the stirring temperature is set to 30-50 degrees Celsius.

[0014] Preferably, the pressure of high pressure sterilization is set to 100-120 kPa, and the temperature of high pressure sterilization is set to 110-130 degrees Celsius.

[0015] Preferably, the high pressure sterilization time is set to 20-40 minutes.

[0016] Preferably, the cooling time is set to 10-20 minutes.

[0017] A wound hemostasis repair composite material is used in preparing a hemostasis material for a human or animal bone tissue wound, and is used in preparing a material for promoting the healing of a human or animal bone tissue wound.

[0018] Compared with the prior art, the technical effects and advantages of the present invention are as follows:

[0019] The wound hemostasis and repair composite material and its preparation method, chitosan is the only alkaline amino polysaccharide in nature. The macromolecular chitosan is adsorbed on the surface of microbial cells to form a polymer film, which can control evaporation and water loss, has good air permeability, improves the performance of exudate discharge, absorbs wound exudate, and prevents infection. At the same time, chitosan can quickly gather blood on the wound to form a gel-like protective film, which plays a role of physical barrier, and it is not easy to adhere to the wound, so it is easy to change the dressing.

[0020] Chitosan has an analgesic effect because it absorbs protons released by acetic acid at the inflamed site; the positive charge carried by the chitosan molecular chain and the mutual attraction with the negatively charged cell wall acid on the cell surface produce an adhesive effect. The adhesion of chitosan to red blood cells causes cell aggregation, promotes blood coagulation, and has a hemostatic effect.

[0021] The wound surface hemostasis and repair composite material and preparation method thereof act in a sterile manner, greatly reducing wound infection. DETAILED DESCRIPTION

[0022] In the following description, a large number of specific details are provided to provide a more thorough understanding of the present invention. However, it is apparent to those skilled in the art that the present invention can be implemented without one or more of these details. In other examples, in order to avoid confusion with the present invention, some technical features well known in the art are not described.

[0023] Chitosan hemostatic powder is suitable for non-chronic wound care, hemostasis, and use on superficial wounds, and is not for use in the body.

[0024] Embodiment 1

[0025] The invention provides a wound hemostasis and repair composite material, comprising chitosan and water, wherein the weight mass proportions of the raw materials are: 10 parts of chitosan and 8 parts of water, wherein the water is set as deionized water, and the invention also comprises a propellant, wherein the propellant is set as one or a mixture of trichloromonofluoromethane, difluoromethane and trichlorotetrafluoroethane.

[0026] A method for preparing a wound hemostasis and repair composite material comprises the following steps:

[0027] Step 1, weigh a specified amount of raw materials, then add chitosan and water into a stirring device, and then stir, the stirring time is set to 60 minutes, the stirring temperature is set to 30 degrees Celsius, to obtain a mixture;

[0028] Step 2: The mixture is then sterilized under high pressure, the pressure of the high pressure sterilization is set to 100-120 kPa, the temperature of the high pressure sterilization is set to 110 degrees Celsius, and the time of the high pressure sterilization is set to 20 minutes;

[0029] Step 3: After the high pressure sterilization is completed, the mixture is cooled to room temperature for 10 minutes, and then inspected. After the inspection is qualified, quantitative packaging is performed to obtain a mixture of the same components;

[0030] Step 4: Introduce the divided mixture into the spraying equipment. The spraying equipment is similar to a spray tank and can withstand a certain pressure. Then, the spraying agent is pressurized and introduced into the spraying equipment. The pressure is set to about 20 kPa.

[0031] A wound hemostasis repair composite material is used in preparing a hemostasis material for a human or animal bone tissue wound, and is used in preparing a material for promoting the healing of a human or animal bone tissue wound.

[0032] Embodiment 2

[0033] The invention provides a wound hemostasis and repair composite material, comprising chitosan and water, wherein the weight mass proportions of the raw materials are: 20 parts of chitosan and 12 parts of water, wherein the water is set as deionized water, and the invention also comprises a propellant, wherein the propellant is set as one or a mixture of trichloromonofluoromethane, difluoromethane and trichlorotetrafluoroethane.

[0034] A method for preparing a wound hemostasis and repair composite material comprises the following steps:

[0035] Step 1, weigh a specified amount of raw materials, then add chitosan and water into a stirring device, and then stir, the stirring time is set to 100 minutes, the stirring temperature is set to 50 degrees Celsius, to obtain a mixture;

[0036] Step 2: The mixture is then sterilized under high pressure, the pressure of the high pressure sterilization is set to 120 kPa, the temperature of the high pressure sterilization is set to 130 degrees Celsius, and the time of the high pressure sterilization is set to 40 minutes;

[0037] Step 3: After the high pressure sterilization is completed, the mixture is cooled to room temperature for 20 minutes, and then inspected. After the inspection is qualified, quantitative packaging is performed to obtain a mixture of the same components;

[0038] Step 4: Introduce the divided mixture into the spraying equipment. The spraying equipment is similar to a spray tank and can withstand a certain pressure. Then, the spraying agent is pressurized and introduced into the spraying equipment. The pressure is set to about 20 kPa.

[0039] A wound hemostasis repair composite material is used in preparing a hemostasis material for a human or animal bone tissue wound, and is used in preparing a material for promoting the healing of a human or animal bone tissue wound.

[0040] Embodiment 3

[0041] The invention provides a wound hemostasis and repair composite material, comprising chitosan and water, wherein the weight mass proportions of the raw materials are: 15 parts of chitosan and 10 parts of water, wherein the water is set as deionized water, and the invention also comprises a propellant, wherein the propellant is set as one or a mixture of trichloromonofluoromethane, difluoromethane and trichlorotetrafluoroethane.

[0042] A method for preparing a wound hemostasis and repair composite material comprises the following steps:

[0043] Step 1, weigh a specified amount of raw materials, then add chitosan and water into a stirring device, and then stir, the stirring time is set to 80 minutes, the stirring temperature is set to 40 degrees Celsius, to obtain a mixture;

[0044] Step 2: The mixture is then sterilized under high pressure, the pressure of the high pressure sterilization is set to 110 kPa, the temperature of the high pressure sterilization is set to 120 degrees Celsius, and the time of the high pressure sterilization is set to 30 minutes;

[0045] Step 3: After the high pressure sterilization is completed, the mixture is cooled to room temperature for 15 minutes, and then inspected. After the inspection is qualified, quantitative packaging is performed to obtain a mixture of the same components;

[0046] Step 4: Introduce the divided mixture into the spraying equipment. The spraying equipment is similar to a spray tank and can withstand a certain pressure. Then, the spraying agent is pressurized and introduced into the spraying equipment. The pressure is set to about 20 kPa.

[0047] A wound hemostasis repair composite material is used in preparing a hemostasis material for a human or animal bone tissue wound, and is used in preparing a material for promoting the healing of a human or animal bone tissue wound.

[0048] Comparison Example

[0049] The invention provides a wound hemostasis and repair composite material, comprising chitosan and water, wherein the weight mass proportions of the raw materials are: 8 parts of chitosan and 20 parts of water, wherein the water is set as deionized water, and the invention also comprises a propellant, wherein the propellant is set as one or a mixture of trichloromonofluoromethane, difluoromethane and trichlorotetrafluoroethane.

[0050] A method for preparing a wound hemostasis and repair composite material comprises the following steps:

[0051] Step 1, weigh a specified amount of raw materials, then add chitosan and water into a stirring device, and then stir, the stirring time is set to 500 minutes, the stirring temperature is set to 60 degrees Celsius, to obtain a mixture;

[0052] Step 2: The mixture is then sterilized under high pressure, the pressure of the high pressure sterilization is set to 130 kPa, the temperature of the high pressure sterilization is set to 110 degrees Celsius, and the time of the high pressure sterilization is set to 60 minutes;

[0053] Step 3: After the high pressure sterilization is completed, the mixture is cooled to room temperature for 6 minutes, and then inspected. After the inspection is qualified, quantitative packaging is performed to obtain a mixture of the same components;

[0054] Step 4: Introduce the divided mixture into the spraying equipment. The spraying equipment is similar to a spray tank and can withstand a certain pressure. Then, the spraying agent is pressurized and introduced into the spraying equipment. The pressure is set to about 20 kPa.

[0055] A wound hemostasis repair composite material is used in preparing a hemostasis material for a human or animal bone tissue wound, and is used in preparing a material for promoting the healing of a human or animal bone tissue wound.

[0056] Comprehensive comparison of multiple experiments shows that the effects of Example 1, Example 2 and Example 3 are better than those of the control example, and among Example 1, Example 2 and Example 3, Example 3 has better effects than Example 1 and Example 2.

[0057] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A wound hemostasis and repair composite material, characterized in that: Including chitosan and water, the weight and mass proportions of each raw material are: 10-20 parts of chitosan, 8-12 parts of water.

2. The wound hemostasis and repair composite material according to claim 1, characterized in that: The water is set to be deionized water.

3. The wound hemostasis and repair composite material according to claim 1, characterized in that: It also includes a propellant, which is set to be one or a mixture of trichloromonofluoromethane, difluoromethane, and trichlorotetrafluoroethane.

4. A method for preparing the wound hemostasis and repair composite material according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1, weighing a specified amount of raw materials, then adding chitosan and water into a stirring device, and then stirring to obtain a mixture; Step 2: then sterilizing the mixture under high pressure; Step 3: After the high pressure sterilization is completed, the mixture is cooled to room temperature and then inspected. After the inspection is qualified, it is quantitatively packaged to obtain a mixture of the same components; Step 4: introduce the divided mixture into the spraying device, and then pressurize the spraying agent into the spraying device.

5. The method for preparing a wound hemostasis and repair composite material according to claim 4, characterized in that: The stirring time is set to 60-100 minutes, and the stirring temperature is set to 30-50 degrees Celsius.

6. The method for preparing a composite material for wound hemostasis and repair according to claim 4, characterized in that: The pressure of the high pressure sterilization is set to 100-120 kPa, and the temperature of the high pressure sterilization is set to 110-130 degrees Celsius.

7. The method for preparing a composite material for wound hemostasis and repair according to claim 6, characterized in that: The high pressure sterilization time is set to 20-40 minutes.

8. The method for preparing a composite material for wound hemostasis and repair according to claim 1, characterized in that: The cooling time is set to 10-20 minutes.

9. Use of the wound hemostasis and repair composite material according to any one of claims 1 to 3 in preparing a hemostatic material for a human or animal bone tissue wound, and in preparing a material for promoting the healing of a human or animal bone tissue wound.