Four-yellow rice wine liniment for treating arthralgia caused by damp-heat stasis and preparation method of four-yellow rice wine liniment

Abstract

The invention provides a four-yellow rice wine liniment for treating arthralgia caused by damp-heat stasis. The four-yellow rice wine liniment is prepared from four Chinese herbal medicines, namely rheum officinale, scutellaria baicalensis, coptis chinensis and golden cypress. The four herbal medicines are soaked in 75% ethanol for 10 days to extract medicinal components, and then a proper amount of honey is added to improve lubricity and comfort. The four-yellow wine liniment has the effects of clearing heat, activating blood, dredging channels, detoxifying, diminishing swelling and relieving pain, and has a remarkable curative effect on arthralgia caused by damp-heat stasis. After the four-yellow wine liniment is applied, the symptoms such as joint swelling, stiffness and pain can be effectively relieved, and the liniment has no obvious toxic or side effect. As a liniment, the liniment is convenient to use and easy to accept by patients, effectively improves the joint function and improves the life quality of the patients. Therefore, the four-yellow wine liniment disclosed by the invention has a wide prospect in clinical application.

Description

[0001] Technical field: The present invention relates to the field of traditional Chinese medicine, and in particular to a four-yellow wine liniment for treating joint pain of damp-heat and blood stasis type. Background Art

[0002] Joint pain is a common disease in modern society. As people age, their joints may become painful due to wear and tear or other factors such as disease. Among them, gouty arthritis, joint injury, osteoarthritis, rheumatism, rheumatoid arthritis, etc. are common diseases that cause joint pain. This pain may seriously affect the patient's daily life, thereby reducing the quality of life.

[0003] Shenzhen is located close to the ocean, with a large average annual rainfall and high humidity. Shenzhen also has a subtropical climate with a high average annual temperature, especially in summer, when the temperature is high and the humidity is high, so it is easy for dampness and heat to accumulate in the body. In addition, modern people, especially residents in coastal areas of Guangdong, like to eat seafood, which is easy to cause dampness and heat. Dampness and heat are considered a kind of pathogenic evil in traditional Chinese medicine. Hot and humid weather can easily lead to the accumulation of dampness and heat in the body. Dampness and heat evil qi will block the meridians, leading to poor circulation of qi and blood, blood stasis, and pain when it is blocked. Secondly, dampness and heat evil qi is particularly good at invading joints, causing redness, swelling, heat and pain in the joints, and limited activity. If the course of the disease develops further, symptoms such as joint deformation and loss of activity may occur. From the perspective of traditional Chinese medicine, joint pain is a manifestation of blocked meridians and poor qi and blood circulation, and dampness and heat are the main causes of blocked meridians and poor qi and blood circulation. Therefore, dampness and heat stasis type joint pain is a common joint disease in clinical practice. According to traditional Chinese medicine theory, dampness and heat stasis is caused by the accumulation of moisture and heat toxins in the body in the joints, leading to joint inflammatory reactions and pain.

[0004] At present, Western medicine mainly treats joint pain through oral or injectable medications, physical therapy, and even surgery. However, these methods usually have significant side effects. For example, anti-inflammatory analgesics can affect the kidneys and gastrointestinal tract, glucocorticoids may cause weight gain, and immunosuppressants may reduce immunity.

[0005] Against this background, TCM's external treatment method has shown its unique advantages. TCM has a history of thousands of years of medical treatment, and has a complete theoretical system and diverse treatment methods. Compared with Western medicine's internal medicine, TCM's external treatment method is safer and has fewer side effects. More importantly, TCM's external treatment method focuses on the exploration and regulation of the cause of the disease, rather than simply eliminating the symptoms. For example, TCM believes that the main cause of joint pain is the invasion of wind, cold, dampness, and heat, or liver and kidney deficiency, blood stasis, etc. Therefore, during treatment, it is necessary not only to eliminate local symptoms, but also to regulate the condition of the entire human body, so that the wind, cold, and dampness in the body can be eliminated, and blood stasis can be relieved.

[0006] External treatment of joint pain by traditional Chinese medicine has high clinical application value and has been widely recognized in practice. The principle of using Chinese herbal liniment to treat joint pain of damp-heat and blood stasis type is that the liniment made by external Chinese herbal medicine has the functions of dredging meridians, dissipating damp-heat, promoting blood circulation and removing blood stasis, improving blood circulation in joints, and promoting the discharge of damp-heat and blood stasis, thereby relieving joint pain and redness and swelling. Chinese herbal liniment generally appears in the form of external ointment or potion. When used, the ointment can be applied to the affected area and gently massaged until absorbed, or the potion can be soaked with gauze and applied to the affected area. The present invention is aimed at the characteristics of common clinical damp-heat and blood stasis type joint pain caused by various reasons, and a Chinese herbal four-yellow wine liniment extracted with ethanol has been developed. The present invention relates to a four-yellow wine Chinese herbal liniment for treating damp-heat and blood stasis type joint pain, which is made of four Chinese herbal medicines: rhubarb, scutellaria, coptis and phellodendron. The four-yellow wine liniment of the invention has the effects of removing dampness and heat, promoting blood circulation and removing blood stasis, relaxing muscles and tendons, and can effectively alleviate the symptoms of joint pain of dampness, heat and blood stasis type. Summary of the invention

[0007] This invention is mainly to provide a Chinese medicine external ointment - Sihuangjiu ointment, to treat damp-heat and blood stasis type joint pain, and to provide an effective Chinese herbal medicine treatment plan, which can improve joint pain and redness and swelling to a certain extent, so as to achieve the purpose of improving joint function.

[0008] The object of the present invention is achieved in the following ways:

[0009] A four-yellow wine liniment for treating joint pain of damp-heat and blood stasis type, the liniment is composed of raw materials in the following weight ratio (as shown in the attached figure of the specification): equal parts (50-100 parts) of scutellaria baicalensis, rhubarb, coptis chinensis and phellodendron amurense, soaked in 75% ethanol (1000-2000 parts) for 10 days, and then added with a small amount of honey. The above-mentioned compatibility prescription is the external Chinese medicine prescription of the Chinese medicine preparation of the present invention for treating joint pain of damp-heat and blood stasis type.

[0010] Furthermore, the Chinese herbal ointment composition for treating joint pain of damp-heat and blood stasis type as described above has a weight ratio of: 50-100 parts of Scutellaria baicalensis, 50-100 parts of Rhubarb, 50-100 parts of Coptis chinensis, and 50-100 parts of Phellodendron amurense.

[0011] Furthermore, the Chinese herbal ointment composition for treating joint pain of damp-heat and blood stasis type as described above, targeting the pathogenesis of damp-heat, has a weight ratio of: 50-100 parts of Scutellaria baicalensis, 50-100 parts of Coptis chinensis, and 50-100 parts of Phellodendron chinense.

[0012] Furthermore, the Chinese herbal ointment composition for treating joint pain of damp-heat and blood stasis type as described above, targeting the pathogenesis of blood stasis and heat, has a weight ratio of: 50-100 parts of Scutellaria baicalensis, 50-100 parts of Coptis chinensis, 50-100 parts of Phellodendron chinense, and 50-100 parts of Rhubarb.

[0013] Furthermore, the Chinese medicine ointment composition for treating damp-heat and blood stasis type joint pain as described above, with respect to the drug extract ethanol used, on the one hand, increases the permeability of the Chinese medicine in the skin, and on the other hand, assists in warming the meridians, promoting blood circulation and relieving pain, and its weight ratio is: 1000-2000 parts of 75% ethanol.

[0014] Furthermore, the Chinese medicine ointment composition for treating damp-heat and blood stasis type joint pain as described above, with respect to the ethanol used, on the one hand, increases the permeability of Chinese medicine in the skin, and on the other hand, assists in warming the meridians, promoting blood circulation and relieving pain, and its weight ratio is: 1000-2000 parts of 75% ethanol.

[0015] Furthermore, the Chinese herbal ointment composition for treating damp-heat and blood stasis type joint pain as described above, with respect to the honey used, on the one hand, prolongs the volatilization time of ethanol when the ointment is applied to the affected area, and on the other hand, assists in relieving pain, and its weight ratio is: 100-200 parts.

[0016] Furthermore, the Chinese herbal ointment composition for treating damp-heat and blood stasis type joint pain as described above is in the form of an alcoholic beverage, a tincture, a powder or an ointment.

[0017] Furthermore, the Chinese medicine liniment composition for treating damp-heat and blood stasis type joint pain as described above is used as an effective ingredient in the preparation of related drugs for treating damp-heat and blood stasis type joint pain.

[0018] The prescription explanation and potential medicinal principle of the Chinese medicinal wine liniment preparation of the present invention are described as follows:

[0019] (1) The creative exploration process of the technical solution of the present invention

[0020] In the scheme for treating various joint pains, in addition to the oral drugs with limited efficacy, the external treatment of traditional Chinese medicine can often achieve very good efficacy. At present, the external Chinese medicine preparations commonly used in clinical practice include solid types such as pills, powders, pills, ingots, tea, koji, roasted, ironed, lines, strips, sticks, cakes, nails, semi-solid preparations such as ointments, pastes, medicines, glues, and liquid preparations such as soups, wine, dew, drinks, tinctures, lacquers, and pastes. Among them, the wine liniment is welcomed by the majority of patients because of its rapid onset, non-toxic, easy to preserve, good transdermal properties, and local non-irritation. Guangdong is located in the south of the Five Ridges, and the climate is hot and humid, which makes the patient's body susceptible to damp-heat evil troubles. Dampness is a tangible evil that easily blocks the qi machine, and over time it is easy to cause blood stasis, thereby forming the pathological symptoms of dampness, heat, and blood stasis. Therefore, the Department of Traditional Chinese Medicine of Shenzhen Bao'an District People's Hospital has achieved definite therapeutic effects by applying the modified Sihuang Powder (rhubarb, scutellaria, coptis, and phellodendron) to treat various joint pains caused by damp heat (described below). However, Sihuang Powder has some defects, including the need for temporary preparation before use, easy drying and shedding, the drug ingredients cannot be fully absorbed by the skin, and it is inconvenient to apply it to certain parts, resulting in poor patient compliance and affecting the overall efficacy. Therefore, the team of doctors in the Department of Traditional Chinese Medicine soaked Sihuang Powder in ethanol and made it into Sihuang Wine Liniment. The liniment is simple to make and has low production cost. It is used for damp-heat stasis type joint pain caused by osteoarthritis, gouty arthritis, rheumatoid arthritis, joint injuries, etc. Patients said that the effect is rapid, the analgesic effect is good, it is easy to apply, it is non-irritating to the skin, it is easy to accept, and it is easy to carry, apply at any time, and easy to store. It has been used in clinical practice and is safe, effective and welcomed by the majority of patients. Because this therapy has obvious Chinese medicine characteristics, a wide range of indications, and a large number of patient sources, it is conducive to the construction and development of specialties, and therefore has both economic and social benefits.

[0021] (2) Clinical development in medical institutions at home and abroad

[0022] At present, Sihuang Powder, which is mainly composed of rhubarb, scutellaria, coptis and phellodendron, has been clinically used to treat a variety of diseases, including fractures, gouty arthritis, phlebitis, perineal edema, pelvic inflammatory disease, bedsores, osteoarthritis, etc. [1-10] Pharmacological studies have shown that rhubarb in Sihuang Powder can improve microcirculation, inhibit the production of lipid peroxides, reduce the content and activity of malondialdehyde, inhibit the activity of myeloperoxidase, and reduce oxidative stress and inflammatory response.

[11] , while regulating immune balance

[12] The coptis root, phellodendron chinense, and scutellaria baicalensis in Sihuang powder can reduce the uric acid level in mice, play a role in reducing swelling and anti-inflammation, and the berberine in coptis root can reduce the swelling, pain score, pro-inflammatory cytokine levels, and joint elastase activity in rats caused by urate crystals. [13-14]It can be seen that Sihuangsan, which is composed of rhubarb, coptis root, phellodendron, and scutellaria, may play a therapeutic role by reducing the level of uric acid in gouty joints and inhibiting the inflammatory response mediated by urate crystals.

[0023] Traditional Chinese medicine liniment refers to a solution, emulsion or suspension made of ethanol, oil or appropriate solvents of traditional Chinese medicine. It is a liquid preparation for rubbing on undamaged skin and is generally made by soaking and percolation. Liniment should be non-toxic and non-irritating to local areas. Commonly used solvents for liniment include water, ethanol, liquid paraffin, glycerin or vegetable oil. In addition, some of the drugs contained in the liniment are absorbed by the epidermis. Sometimes they must be added to flannel or other soft materials and gently wrapped on the affected area. The flannel or other soft materials used must be clean and slowly release the drugs to play a therapeutic role. Because most of the effective drug ingredients in traditional Chinese medicine have been extracted from the liniment, it can be directly absorbed through the skin when applied to the skin. This is a feature that cannot be compared with Sihuang powder, and it has an irreplaceable role in relieving joint pain. Some studies have used Sanhuang liniment (rhubarb, phellodendron, scutellaria combined with sophora flavescens) to treat external symptoms of dampness and toxicity infiltration, which has the effect of clearing heat and swelling, relieving itching and moisture.

[15] .

[0024] Shenzhen is warm and humid all year round, which is easy to gather dampness and produce evil. The dampness is lingering and sticky, which troubles the human body for a long time, and is easy to block the Qi. Over time, Qi stagnation turns into heat, which is easy to cause dampness and heat stagnation. However, Qi is the leader of blood. The stagnation of Qi for a long time will inevitably lead to blood stagnation and even blood stasis. Therefore, the invasion of dampness and heat into the joints often leads to repeated attacks of pain, which is difficult to heal. If it is not taken care of, the dampness and heat cannot be eliminated, the blood stasis is not removed, and the tendons and veins are blocked, which will cause joint swelling and deformation, and activity disorders, thus affecting the quality of life of patients. Therefore, the four-yellow wine liniment produced by our department is an excellent dosage form for joint pain caused by various arthritis, including but not limited to, and is especially suitable for joint pain caused by dampness and heat. At present, the four-yellow wine liniment developed for Shenzhen and even the whole country has not been carried out in domestic hospitals. Beneficial Effects

[0025]

References

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[15] Li Wenlong, Lv Weizhong, Li Jishuang. Clinical observation on the treatment of chronic eczema with Sanhuang ointment[J]. Guangming Chinese Medicine, 2022, 37(04): 571-573. (3) Analysis of the efficacy and formula of the Chinese medicine components of the present invention In view of the characteristics of joint pain attacks, this research team used Sihuang Powder and added ethanol to extract its medicinal ingredients. This not only retained the medicinal efficacy of the original Chinese medicinal materials, but also introduced ethanol to increase skin permeability and sterilization properties. Analysis: Since dampness and heat are the pathological factors of joint pain, clearing away heat and drying dampness are the main functions of this medicine. Taking into account that dampness is sticky, it blocks the Qi and causes blood stasis, which causes pain, so it needs to be supplemented with methods of promoting blood circulation and removing blood stasis. Rhizoma Coptidis, Radix Scutellariae, and Radix Phellodendri are bitter and cold in nature, clearing away heat and dampness, purging fire and detoxifying, and cooling blood. Studies have shown that Rhizoma Coptidis and its main component berberine have antipyretic and significant anti-inflammatory effects, and can also resist platelet aggregation. Radix Scutellariae is used to treat sores, carbuncles, and swellings. Studies have shown that baicalin and baicalein have inhibitory effects on acute and chronic inflammation, and can reduce the permeability of capillaries and reduce the release of allergic mediators. Radix Scutellariae decoction alcohol precipitation, baicalin, and total flavonoids of Radix Scutellariae have obvious antipyretic effects. Radix Phellodendri is good at purging phase fire and relieving bone steaming, and can also clear heat and dampness, purge fire and detoxify. Studies have shown that Radix Phellodendri and its berberine component have significant anti-inflammatory hyperplasia, anti-arrhythmia, antihypertensive, sedative, and anti-gout effects. Phellodendron chinense, Scutellaria baicalensis and Coptis chinensis are bitter and cold in nature and can clear away heat and dampness, purge fire and detoxify. They are often used together to treat various symptoms caused by damp-heat and fire toxicity. Rhubarb is bitter and cold, and it enters the spleen, stomach, large intestine, liver, and pericardium meridians. Efficacy: It can clear away heat and fire, cool blood and detoxify, remove blood stasis and promote menstruation, and relieve dampness and jaundice. External use can clear away heat and fire, cool blood and detoxify, and can also promote blood circulation and remove blood stasis. When used in combination with coptis root, scutellaria baicalensis, and phellodendron, it can strengthen the heat and dampness removal, and can also promote blood circulation and dredge collaterals, which will relieve pain. Beneficial Effects In order to accurately illustrate the clinically significant effects of the Chinese medicine ointment formula applied in the present invention, since April 2023, Sihuangjiu ointment has been clinically used to treat more than 33 patients with various types of damp-heat and blood stasis type joint pain, including 21 males and 12 females, aged between 32-68 years old. These patients had used oral non-steroidal anti-inflammatory drugs before hospitalization and could not control the pain symptoms, or the pain could not be significantly relieved. They all showed varying degrees of increased skin temperature in the affected area, obvious heat sensation, joint swelling, pain, tenderness, and severe pain when pressed. Among them, there were 16 patients with gouty arthritis, 8 patients with knee joint injury, 4 patients with knee osteoarthritis, 2 patients with rheumatoid arthritis, and 3 patients with frozen shoulder. These patients were treated with Sihuangjiu ointment (1 time / day or 2 times / day) after admission. Among the 33 patients, the relief rate of joint pain was 78% after applying Sihuangjiu Liniment once, 92% after applying it twice, and 97% after applying it three times. While the pain symptoms of these patients were relieved, the swelling and heat in the joints were also significantly relieved. At the same time, no adverse reactions occurred in the 33 patients after treatment with Sihuangjiu Liniment. The specific beneficial technical effects summarized based on clinical practice are as follows: (1) The Chinese medicine wine liniment of the present invention has been scientifically formulated and used in an exploratory manner, overcoming some of the shortcomings of the use of Sihuang powder in the early clinical stage, and improving the clinical efficacy. The Chinese medicine formula is ingenious and concise, and clinical application has verified that the Chinese medicine wine liniment can quickly and effectively improve the local joint symptoms of patients with damp-heat and blood stasis type joint pain, enhance joint function to a certain extent, and long-term use can improve joint function and avoid the side effects of taking chemical drugs such as non-steroidal anti-inflammatory drugs, thereby promoting patient recovery. (2) The four-yellow wine liniment of the present invention is used clinically to treat patients with damp-heat and blood stasis type joint pain. It can not only effectively improve the patients' joint pain, swelling, increased skin temperature and other symptoms, but also is easy to use and has almost no adverse reactions, thereby improving the treatment effect and rehabilitation effect of such patients. Figure 1 This is the drug composition and production flow chart of Sihuangjiu Ointment. The Chinese medicine preparation described in the present invention has been applied in the clinical practice treatment of joint pain in which the team of the present invention participated, and a large case sample is used for the treatment of all joint pains that meet the damp-heat or blood stasis syndrome. The Chinese medicine prescription of the present invention is formed by closely following the potential medicine of traditional Chinese medicine syndrome differentiation and treatment. For this reason, the clinical efficacy data of certain representative patients with damp-heat and blood stasis type joint pain are selected to illustrate the implementable process of the present invention, but the embodiments of the present invention are not limited to this. Example 1 Preparation of the Chinese medicine composition of the four yellow wine liniment of the present invention A. Composition ratio: equal parts of Scutellaria baicalensis, Rhubarb, Coptis chinensis, and Phellodendron chinense. B. Preparation method: select 50-100 parts of each of Scutellaria baicalensis, Rhubarb, Coptis chinensis and Phellodendron amurense in the above "A", wash and slice them, put them in a sealed container, add sufficient 75% ethanol (1000-2000 parts) for soaking, seal and store for 10 days, then take out the exudate, add appropriate amount of honey and stir evenly, and the obtained is the four-yellow wine ointment of the present invention. C. Usage: Take an appropriate amount of Sihuangjiu Liniment, apply it directly or soak a sterile gauze with the liniment and apply it to the area of ​​joint pain, once a day. If the symptoms are severe, apply it twice a day. Use it for 3 consecutive days as a course of treatment. Clinically validated: Through clinical tests, 33 patients with various types of joint pain were treated with the four-yellow wine liniment of the present invention, and the effective rate reached 98%, and no adverse reactions occurred. It is easy to use, indicating that the four-yellow wine liniment of the present invention has a high practical value for treating damp-heat and blood stasis type joint pain. Example 2 Clinical case efficacy of patients with gouty arthritis Tang, male, age: 38 years old. The patient was diagnosed with "gouty arthritis for more than 2 years" and was admitted to the hospital. The patient was admitted to the hospital on May 16, 2023. The current symptoms were: the patient had a painful face, swollen and painful right knee joint, refused to press, the skin temperature of the affected area was significantly higher than the left knee, the right lower limb was not active, lame, dry mouth, sticky mouth, fatigue, red tongue, thickened and blue veins under the tongue, greasy and slightly yellow tongue coating, stringy and slippery pulse, and oral Febuxostat, celecoxib capsules or diclofenac sodium sustained-release tablets had no significant relief of pain symptoms. According to traditional Chinese medicine, damp-heat stasis was observed, and the four yellow wine liniment prepared in the above "Example 1" of the present invention was soaked in gauze and applied to the affected joints, 2 times / day, for 3 consecutive days, and no analgesics such as non-steroidal anti-inflammatory drugs were taken during the period. Three days later, the patient's right knee joint pain symptoms were significantly relieved, skin temperature decreased, and swelling significantly subsided. Chinese medicine was continued to be taken orally to consolidate the therapeutic effect. Example 3 Clinical Case Efficacy of Rheumatoid Arthritis Patients Ji, gender: female, age: 56 years old. Due to the aggravation of swollen and painful joints of both fingers for 7 days, the patient was diagnosed with "rheumatoid arthritis" in an external hospital for more than 5 years and was admitted to the hospital. The symptoms of admission were: swollen and tender joints of both fingers, hot sensation when touched, and poor flexion and extension, which affected daily life. The patient complained that the pain symptoms were relieved after taking other oral analgesics such as diclofenac sodium sustained-release tablets and applying the self-purchased "plaster" at home, but it recurred soon after, with dry mouth, bitter mouth, painful face, dark red tongue, thick and greasy yellow fur, and smooth pulse. TCM syndrome differentiation of damp-heat and blood stasis. The four yellow wine liniment prepared by the above-mentioned "Example 1" of the present invention was applied externally, twice a day, for 3 consecutive days. After the first day of using the four yellow wine liniment, the patient complained that the pain was relieved. After the third day, the patient complained that the swelling and pain of the joints of both fingers were significantly relieved, and the flexion and extension activities were smoother than before, and he could hold objects daily. After discharge, he continued to take Chinese medicine for oral administration to consolidate the therapeutic effect. In summary, the Sihuangjiu liniment for treating damp-heat and blood stasis type joint pain proposed in the present invention not only has significant therapeutic effects, but is also made from Chinese herbal medicine, so it is safe, non-toxic, and easy to use, which greatly meets the actual needs of patients with various types of joint pain. Please review and approve. Description of the drawings: The ointment is prepared by mixing the Chinese medicinal pieces of scutellaria baicalensis, rhubarb, coptis chinensis and phellodendron amurense in equal parts (50-100 parts) by weight, soaking them in 75% medical ethanol (1000-2000 parts) for 10 days, filtering the residues with a Chinese medicinal filter cloth, taking the filtrate, and adding a proper amount of commercially available honey to prepare the four-yellow wine ointment.

Claims

1. Claim 1: A four-yellow wine liniment for treating joint pain of damp-heat stasis type, characterized in that: The ointment is composed of equal parts of Scutellaria baicalensis, Rhubarb, Coptis chinensis and Phellodendron amurense, and is soaked in 75% ethanol for 10 days and then added with a small amount of honey.

2. Claim 2: The four-yellow wine liniment according to claim 1, characterized in that: The preparation method of the ointment comprises: taking equal parts of scutellaria baicalensis, rhubarb, coptis chinensis and phellodendron chinense, soaking them in 75% ethanol for 10 days, and then adding appropriate amount of honey.

3. Claim 3: The four-yellow wine liniment according to claim 1 or 2, characterized in that: For diseases caused by damp-heat, the Chinese medicine composition further includes raw materials in the following weight ratio: 50-100 parts of Coptis chinensis, 50-100 parts of Phellodendron chinense, and 50-100 parts of Scutellaria baicalensis.

4. Claim 4: The four-yellow wine liniment according to claim 1 or 2, characterized in that: For diseases caused by blood stasis and heat, the Chinese medicine composition further includes raw materials in the following weight ratio: 50-100 parts of rhubarb, 50-100 parts of coptis chinensis, and 50-100 parts of phellodendron chinense.

5. Claim 5: The four-yellow wine liniment according to claim 1 or 2, characterized in that: The 75% ethanol used as the Chinese medicinal material extract has a weight ratio of 1000-2000 parts. It can not only be directly applied to the skin, but also has good permeability, and has the effects of promoting blood circulation, dispersing blood stasis, unblocking meridians and relieving pain.

6. Claim 6: The four-yellow wine liniment according to claim 1 or 2, characterized in that: The honey used, due to its sticky, nourishing and soothing properties, can not only slow down the rapid evaporation of ethanol when the medicinal ointment is applied to the affected area, but also has the characteristics of moisturizing the skin and relieving pain.

7. Claim 7: The four yellow wine liniment according to claims 1 to 6, characterized in that: Sihuangjiu ointment has a significant therapeutic effect on joint pain of damp-heat and blood stasis type. The efficacy in clinical trials was as high as 98%, and no adverse reactions occurred.

8. Claim 8: The four-yellow wine liniment according to any one of claims 1 to 7, characterized in that: Since Sihuangjiu Ointment is made from natural Chinese herbal medicine, it is safe to use and does not produce toxic side effects.

9. Claim 9: The four-yellow wine liniment according to any one of claims 1 to 8, characterized in that: The method of using Sihuangjiu Ointment is to apply it directly to the affected area. It has the advantages of being easy to use and having quick effects.

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