Vascular repair device and vascular repair method

Abstract

The invention provides a blood vessel repairing device and a blood vessel repairing method. The blood vessel repairing device comprises an air inlet pipe and a balloon. The balloon comprises a first surface and a second surface, the first surface and the second surface jointly define an inner cavity, the first surface is configured to enable gas to penetrate through and be capable of blocking liquid, and the second surface is configured to enable part of the liquid to penetrate through and be capable of blocking the gas. The air inlet pipe penetrates through one side of the first surface along the length direction of the blood vessel, and one side of the second surface along the width direction of the blood vessel is suitable for facing the blood vessel. According to the blood vessel repairing device, gas and liquid can be mixed, and then a product with a treatment effect directly acts on a target part, so that treatment is more efficient, and adverse effects caused by oral medicine are avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of blood vessel repair, and in particular to a blood vessel repair device and a blood vessel repair method. Background Art

[0002] Vascular endothelial injury is an important pathological process of coronary heart disease. On the one hand, lipid accumulation under early damaged endothelium leads to the gradual formation of atherosclerotic plaques. Early repair intervention of vascular endothelium can effectively slow down the process of atherosclerosis. On the other hand, vascular endothelial injury is also one of the direct negative effects of interventional treatment, including guidewire passage, stent implantation, balloon dilatation and other processes. Timely repair of endothelial injury after intervention can effectively reduce the incidence of postoperative adverse events. Studies have found that endothelial cell injury is a reversible change that can be repaired in a variety of ways, such as through exercise, taking angiotensin-converting enzyme inhibitors (ACEI Angiotensin-Converting Enzyme Inhibitors), angiotensin receptor antagonists (ARB Angiotensin Receptor Blockers), beta-blockers, etc.

[0003] In the related technology, oral drugs are used to treat vascular endothelial damage, but oral drugs have many disadvantages, such as not directly acting on the target site, having certain systemic side effects, and being highly selective for the target patient group. For example, angiotensin-converting enzyme inhibitors (ACEI) may cause hyperkalemia, renal damage, etc., and are contraindicated in patients with severe renal damage or hyperkalemia; beta-blockers may mask warning symptoms related to hypoglycemia, so they should be used with caution in diabetic patients; in addition, beta-blockers may also cause increased airway resistance, so they are contraindicated in patients with asthma or bronchospastic COPD. Therefore, the development of highly targeted vascular endothelial damage repair tools will effectively reduce the toxic side effects of drugs and achieve more efficient damage repair treatment. Summary of the invention

[0004] The main purpose of the present invention is to provide a vascular repair device and a vascular repair method, which can make the treatment more efficient and avoid the adverse effects of oral medication.

[0005] To achieve the above objectives, the embodiments of the present invention adopt the following technical solutions: Vascular repair devices, including inlet tubes and balloons; The balloon comprises a first surface and a second surface, the first surface and the second surface jointly define an inner cavity, the first surface is configured to allow gas to pass through and to block liquid, and the second surface is configured to allow liquid to partially pass through and to block gas; The air inlet pipe is arranged on one side of the first surface along the length direction of the blood vessel, and one side of the second surface along the width direction of the blood vessel is suitable for facing the blood vessel.

[0006] In some embodiments, the air inlet tube includes an inner tube and an outer tube, the outer tube is sleeved on the outside of the inner tube, the inner tube defines a first guide wire cavity, an air guide cavity is defined between the inner tube and the outer tube, and the air guide cavity is suitable for passing gas. The vascular repair device also includes a guide wire tube, the guide wire tube and the air inlet tube are respectively connected to both sides of the balloon along the length direction, the guide wire tube defines a second guide wire cavity, the first guide wire cavity and the second guide wire cavity are coaxially arranged and are both suitable for inserting a guide wire for interventional treatment.

[0007] In some embodiments, a first annular electrode extending in a circumferential direction is provided on the outer surface of the inner tube, and a second annular electrode extending in a circumferential direction is provided on the inner surface of the outer tube. The first annular electrode and the second annular electrode are configured to ionize the gas in the gas guide cavity and form plasma after being energized.

[0008] In some embodiments, the vascular repair device further includes an air outlet tube, and along the length direction of the blood vessel, the first surface is distributed on both sides of the balloon, and the air inlet tube is arranged through the first surface on one side, and the air outlet tube is arranged through the first surface on the other side.

[0009] In some embodiments, the outlet pipe includes a first pipe and a second pipe, the maximum outflow area of ​​the first pipe is S1, the maximum outflow area of ​​the second pipe is S2, the maximum outflow area of ​​the inlet pipe is S3, and it satisfies: S1+S2≥S3.

[0010] In some embodiments, the air inlet tube includes an inner tube and an outer tube, the outer tube is sleeved on the outer side of the inner tube, the inner tube defines a first guide wire cavity, an air guide cavity is defined between the inner tube and the outer tube, and the air guide cavity is suitable for passing gas, the vascular repair device also includes a guide wire tube, the guide wire tube and the air inlet tube are respectively connected to the two sides of the balloon along the length direction, the guide wire tube defines a second guide wire cavity, the first guide wire cavity and the second guide wire cavity are coaxially arranged and are both suitable for inserting a guide wire for interventional treatment; The air outlet tube includes a first tube and a second tube. Along the direction perpendicular to the length direction, the first tube and the second tube are respectively connected to two sides of the balloon, and the second guide wire cavity is located between the first tube and the second tube.

[0011] In some embodiments, the balloon is oval in shape when viewed along the length of the blood vessel.

[0012] In some embodiments, the balloon includes a grid mesh disposed in the inner cavity, the grid mesh facing the airway along the length of the blood vessel.

[0013] The embodiment of the second aspect of the present invention further provides a blood vessel repair method, using the blood vessel repair device of any of the above embodiments, the blood vessel repair method comprising: Pass the gas into the air inlet pipe; Ionize the gas to form plasma; Mixing the plasma in the inner cavity with physiological saline to form a plasma activation solution; The plasma activated liquid is made to pass through the second surface along the width direction of the blood vessel and reach the endothelium of the blood vessel.

[0014] In some embodiments, the gas is nitrogen, so that the plasma is a nitrogen plasma.

[0015] Compared with the prior art, the present invention has the following beneficial effects: The vascular repair device of the present invention includes an air inlet tube and a balloon. The first surface and the second surface of the balloon jointly define an inner cavity, and the first surface has a property of being air-permeable but water-impermeable, and the second surface has a property of being partially water-permeable but air-impermeable. The air inlet tube is arranged on one side of the first surface along the length direction of the blood vessel, and the side of the second surface along the width direction of the blood vessel is suitable for facing the blood vessel, so that the gas can be introduced into the balloon through the air inlet tube, and the liquid in the balloon will not pass through the first surface into the air inlet tube, and the liquid in the balloon can be mixed with the gas and then transported to the vascular endothelium through the second surface. Compared with the use of oral drugs to treat vascular endothelial damage in the related art, the vascular repair device of the present invention can mix gas and liquid, and then directly apply the product with therapeutic efficacy to the target site, making the treatment more efficient and avoiding the adverse effects of oral drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0017] Figure 1 It is a first side schematic diagram of a blood vessel repair device provided in a first embodiment of the present invention; Figure 2 It is a second side schematic diagram of the blood vessel repair device provided in the first embodiment of the present invention; Figure 3 It is a third side schematic diagram of the blood vessel repair device provided in the first embodiment of the present invention; Figure 4 A first side schematic diagram of a blood vessel repair device and a blood vessel provided in a second embodiment of the present invention; Figure 5 A second side schematic diagram of a blood vessel repair device provided in a second embodiment of the present invention; Figure 6 A schematic diagram of the material flow direction of the blood vessel repair device provided in the second embodiment of the present invention; Figure 7 This is a flow chart of the blood vessel repair method provided in an embodiment of the second aspect of the present invention.

[0018] Description of Figure Numbers: Vascular repair device 100; Air inlet pipe 110; inner pipe 111; outer pipe 112; first guide wire cavity 113; air guide cavity 114; first annular electrode 115; second annular electrode 116; Balloon 120; first surface 121; second surface 122; inner cavity 123; grid 124; An air outlet pipe 130; a first pipe 131; a second pipe 132; Liquid supply pipe 140; Guide wire tube 150; second guide wire cavity 151; Blood vessels 200; Length direction X; Width direction Y.

[0019] The realization of the purpose, functional features and advantages of the present invention will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] It should be noted that if the embodiments of the present invention involve directional indications (such as up, down, left, right, front, back, etc.), the directional indications are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0022] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present invention, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features limited to "first" and "second" may explicitly or implicitly include at least one of the features. In addition, if "and / or", "and / or" or "and / or" appears in the full text, its meaning includes three parallel schemes. Taking "A and / or B" as an example, it includes scheme A, or scheme B, or a scheme that satisfies both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in the field to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0023] In the related technology, oral drugs are used to treat vascular endothelial damage, but oral drugs have many disadvantages, such as not directly acting on the target site, having certain systemic side effects, and being highly selective for the target patient group. For example, angiotensin-converting enzyme inhibitors (ACEI) may cause hyperkalemia, renal damage, etc., and are contraindicated in patients with severe renal damage or hyperkalemia; beta-blockers may mask warning symptoms related to hypoglycemia, so they should be used with caution in diabetic patients; in addition, beta-blockers may also cause increased airway resistance, so they are contraindicated in patients with asthma or bronchospastic COPD. Therefore, the development of highly targeted vascular endothelial damage repair tools will effectively reduce the toxic side effects of drugs and achieve more efficient damage repair treatment.

[0024] In view of this, see Figure 1-Figure 6 In an embodiment of the present invention, a vascular repair device 100 is provided. The vascular repair device 100 includes an air inlet tube 110 and a balloon 120 .

[0025] For details, see Figure 1-Figure 3 According to the requirements, the air inlet pipe 110 can be of any shape and material. In order to facilitate the installation to the patient's part, the air inlet pipe 110 can be a hose.

[0026] See also Figure 1-Figure 3The balloon 120 includes a first surface 121 and a second surface 122, and the first surface 121 and the second surface 122 together define an inner cavity 123. The first surface 121 is configured to allow gas to pass through and to block liquid, and the second surface 122 is configured to allow liquid to partially pass through and to block gas. The air inlet pipe 110 is provided on one side of the first surface 121 along the length direction X of the blood vessel 200, and the second surface 122 is adapted to face the blood vessel 200 on one side along the width direction Y of the blood vessel 200. It can be understood that the first surface 121 and the second surface 122 are both surface structures of the balloon 120, and can be a membrane structure. The first surface 121 and the second surface 122 can define the inner cavity 123 of the balloon 120 itself. In some embodiments, the balloon 120 can be entirely composed of the first surface 121 and the second surface 122; in other embodiments, the balloon 120 includes other surface structures (whose materials can be the same as or different from those of the first balloon 120) in addition to the first surface 121 and the second surface 122. Based on this, by specially setting the properties of the first surface 121 and the second surface 122, the gas can be introduced into the balloon 120 from the air inlet pipe 110, and the liquid in the balloon 120 (which can be stored in the balloon 120 itself or introduced into the balloon 120 through other structures) will not pass through the first surface 121 into the air inlet pipe 110, and the liquid in the balloon 120 can be mixed with the gas (including reacting with the gas) and then transported to the vicinity of the endothelium of the blood vessel 200 through the second surface 122. According to the above functional description, the balloon 120 can be in any suitable structural shape, which is not limited here.

[0027] Based on the above configuration, a specific implementation method is described below. Figure 1-Figure 3In some embodiments, the air inlet 110 can transport gaseous nitrogen plasma from the first surface 121 to the inner cavity 123. The inner cavity 123 is connected to an infusion tube to transport saline to the inner cavity 123. The nitrogen plasma is mixed with the saline to form a plasma activated liquid. After the balloon 120 is squeezed, the plasma activated liquid is further transported from the second surface 122 to the endothelium of the blood vessel 200, so that the nitrogen plasma activated liquid acts on the endothelium of the blood vessel 200 to produce a therapeutic effect. Among them, the plasma activated liquid refers to a liquid with physical and chemical activities produced by the interaction between plasma and liquid. Plasma is the fourth state of matter, which contains a large number of active particles such as ions, electrons, excited atoms and molecules, and free radicals. When plasma contacts liquid, these active particles will be transferred to the liquid, causing the properties of the liquid to change, thereby forming a plasma activated liquid. Previous studies have shown that active substances contained in plasma of appropriate concentrations, such as active nitrogen substances, can promote the formation of human umbilical vein endothelial cells (HUVEC) pipelines; there are also studies that plasma treatment can promote the regeneration of blood vessels 200. For ease of description, the following description will be based on the application of the vascular repair device 100 to the above-described implementation.

[0028] It should be noted that the vascular repair device 100 and the vascular repair method of the present invention can be applied to any treatment method that requires delivering substances to the endothelium of the blood vessel 200. The specific form of treatment can be repairing injuries, treating diseases, palliative treatment, etc.

[0029] It can be seen that the vascular repair device 100 of the present invention includes an air inlet tube 110 and a balloon 120. The first surface 121 and the second surface 122 of the balloon 120 jointly define an inner cavity 123, and the first surface 121 has the property of being air-permeable and water-impermeable, and the second surface 122 has the property of being partially water-permeable and air-impermeable. The air inlet tube 110 is arranged on one side of the first surface 121 along the length direction X of the blood vessel 200, and the side of the second surface 122 along the width direction Y of the blood vessel 200 is suitable for facing the blood vessel 200, so that the gas can be introduced into the balloon 120 from the air inlet tube 110, and the liquid in the balloon 120 will not pass through the first surface 121 into the air inlet tube 110, and the liquid in the balloon 120 can be mixed with the gas and then transported to the endothelium of the blood vessel 200 through the second surface 122. Compared with the related art that uses oral drugs to treat endothelial damage in blood vessels 200, the vascular repair device 100 of the present invention can mix gas and liquid, and then directly apply the product with therapeutic efficacy to the target site, making the treatment more efficient and avoiding the adverse effects of oral drugs. The treatment based on the vascular repair device 100 of the present invention will generally serve as a secondary prevention measure, which helps to control risk factors, prevent disease progression and improve prognosis. For patients who have already developed coronary heart disease and other atherosclerotic vascular 200 diseases, preventive treatment for endothelial damage repair can be performed regularly. Timely endothelial repair treatment after interventional surgery helps to effectively reduce the occurrence of adverse events such as dissection tears and new lipid accumulation; it also helps to promptly repair the intimal cracks at the stent, which helps to achieve more rapid stent endothelialization and less acute events such as stent thrombosis.

[0030] For the specific configuration of the air intake pipe 110, see Figure 4In some embodiments, the air inlet tube 110 includes an inner tube 111 and an outer tube 112, and the outer tube 112 is sleeved on the outer side of the inner tube 111. Through the above arrangement, the inner tube 111 can define a first guidewire cavity 113, and the vascular repair device 100 also includes a guidewire tube 150, which is connected to the air inlet tube 110 at both sides of the balloon 120 along the length direction X, and the guidewire tube 150 defines a second guidewire cavity 151, and the first guidewire cavity 113 and the second guidewire cavity 151 are coaxially arranged and are both suitable for inserting a guidewire for interventional treatment. Among them, the first guidewire cavity 113 is the cavity of the inner tube 111 itself, and the first guidewire cavity 113 and the second guidewire cavity 151 can be suitable for guidewires to pass through at the same time. The size of the first guidewire cavity 113 and the second guidewire cavity 151 can adapt to the size of the commonly used guidewires in cardiovascular interventional surgery 200, and can enter the target blood vessel 200 through the radial artery or femoral artery in an OTW (Over the Wire) manner. In the interventional treatment of endothelial injury of the blood vessel 200, the guidewire can mainly play a guiding role and a supporting role. The guiding role is that the guidewire can enter from the peripheral blood vessel 200 (such as the radial artery or the femoral artery), follow the natural direction of the blood vessel 200, pass through the complex branches and bends of the blood vessel 200, and open up a path for subsequent various instruments (vascular repair device 100 or other auxiliary instruments); the supporting role is that the guidewire can provide a certain support force in the blood vessel 200 to prevent the subsequent catheter and other instruments from being folded or twisted when passing through the curved blood vessel 200. At the same time, the guidewire can also provide stable support for various instruments. An air guide cavity 114 is defined between the inner tube 111 and the outer tube 112, and the air guide cavity 114 is suitable for passing gas. The air guide cavity 114 is a cavity formed between the outer surface of the inner tube 111 and the inner surface of the outer tube 112, through which gas can pass, and the gas can be passed through other structures of the vascular repair device 100, or through an external device. By setting the inner tube 111 and the outer tube 112, and forming the first guide wire cavity 113 and the air guide cavity 114, the structure of the vascular repair device 100 can be made more concise and more practical.

[0031] Based on the inner tube 111 and the outer tube 112 defined in the above embodiment, in order to generate the plasma required for treatment, see Figure 4In some embodiments, the outer surface of the inner tube 111 is provided with a first annular electrode 115, and the inner surface of the outer tube 112 is provided with a second annular electrode 116. The first annular electrode 115 and the second annular electrode 116 are both annular, that is, they extend in the direction of the circumferential length direction X. The first annular electrode 115 and the second annular electrode 116 are configured to ionize the gas in the gas guide cavity 114 and form plasma after being energized. Through the above-mentioned setting, when in use, the gas can be first introduced into the gas guide cavity 114. When the gas reaches the position where the first annular electrode 115 and the second annular electrode 116 are located, the nitrogen can be ionized into plasma through the energization of the two electrodes. Thereafter, the plasma can enter the inner cavity 123 of the balloon 120 and mix with physiological saline to form a plasma activation solution. According to requirements, in other embodiments, other electrodes of any suitable shape can also be provided, and they can also ionize to form plasma. In some other embodiments, the plasma may not be formed in the air inlet pipe 110 , but may be directly transported into the air inlet pipe 110 , thereby the plasma may be formed by other structures disposed outside.

[0032] In order to further process the gas in the balloon 120 (the gas in the balloon 120 described in the present invention includes unionized gas and plasma), see Figure 4 In some embodiments, the vascular repair device 100 further includes an air outlet pipe 130. To facilitate the gas to pass through the balloon 120 and be discharged from the air outlet pipe 130, the first surface 121 is distributed on both sides of the balloon 120 along the length direction X of the blood vessel 200, and the air inlet pipe 110 is provided on the first surface 121 on one side, and the air outlet pipe 130 is provided on the first surface 121 on the other side. Through the above arrangement, the gas can be discharged from the inner cavity 123 of the balloon 120, so that the gas in the inner cavity 123 will not be squeezed and maintain a flowing state, thereby achieving a better treatment effect. According to requirements, in other embodiments, along the length direction X, the air outlet pipe 130 and the air inlet pipe 110 can be connected to the same side of the balloon 120.

[0033] For further information, see Figure 4 , Figure 5 or Figure 6In some embodiments, the outlet pipe 130 includes a first pipe 131 and a second pipe 132. The shape and structure of the first pipe 131 and the second pipe 132 may be the same or different. In some embodiments, the maximum outflow area of ​​the first pipe 131 is S1, the maximum outflow area of ​​the second pipe 132 is S2, and the maximum outflow area of ​​the inlet pipe 110 is S3, and it satisfies: S1+S2≥S3. It can be understood that the above-mentioned limitation makes the total outflow area of ​​the outlet pipe 130 equal to or greater than the outflow area of ​​the inlet pipe 110. By controlling the size of the inlet / outlet pipe 130, the pressure on the membrane of the inlet / outlet end balloon 120 can be controlled to ensure air permeability and watertightness. At the same time, if the total size of the outlet pipe 130 is too small, it is easy to make the gas in the balloon 120 difficult to discharge normally, and affect the ionization plasma effect at the inlet pipe 110 and the gas transportation effect. According to the needs, in other embodiments, S1+S2<S3.

[0034] In addition, see Figure 4 , Figure 5 or Figure 6 In some embodiments, along the direction perpendicular to the length direction X, the first tube 131 and the second tube 132 are respectively connected to the two sides of the balloon 120, the air inlet tube 110 is located between the first tube 131 and the second tube 132, and the guide wire tube 150 is located between the first tube 131 and the second tube 132. The above arrangement can, on the one hand, form an escape space between the first tube 131 and the second tube 132 on the opposite side of the guide wire tube 150, thereby facilitating the guide wire or other instruments to pass through the escape space; on the other hand, by arranging the air inlet tube 110 between the first tube 131 and the second tube 132 (the axis of the air inlet tube 110 can also coincide with the axis of the balloon 120), the position where the gas enters the balloon 120 can be approximately located near the axis of the balloon 120, that is, the gas is introduced into the balloon 120 from the middle part, so that the gas distribution and gas movement in the balloon 120 are more uniform, and it is conducive to the mixing of plasma and physiological saline. More specifically, in some embodiments, the first tube 131 and the second tube 132 are symmetrically arranged with the axis of the air inlet tube 110 (or the balloon 120 ) as the center.

[0035] See also Figure 4 In some embodiments, the balloon 120 is elliptical when viewed along the length direction X of the blood vessel 200. The above facilities enable the two sides of the balloon 120 with a longer dimension to be attached to the blood vessel 200 in a direction perpendicular to the length direction X. The second surface 122 of the above embodiment can be provided on the two sides of the balloon 120 with a longer dimension, and the plasma activated liquid derived from the sides can act on the endothelium of the blood vessel 200 more efficiently; while the two sides with a shorter dimension maintain a distance from the inner wall of the blood vessel 200, and the distance can facilitate the passage of blood.

[0036] See also Figure 4In some embodiments, the balloon 120 includes a grid 124 disposed in the inner cavity 123, and the grid 124 faces the air inlet pipe 110 along the length direction X of the blood vessel 200. The grid 124 can play a role in breaking up gas and bubbles, and larger bubbles can be broken into nanometer-scale small bubbles. Therefore, the grid 124 can be disposed in the air inlet pipe 110 (and downstream of the first annular electrode 115 and the second annular electrode 116), or the grid 124 can be disposed in the balloon 120, specifically, on the side of the balloon 120 close to the air inlet pipe 110 along the length direction X.

[0037] See also Figure 4 In some embodiments, the vascular repair device 100 further includes a liquid supply tube 140 , which is connected to the inner cavity 123 of the balloon 120 . The liquid supply tube 140 can serve as an inlet and outlet of physiological saline in the inner cavity 123 and is used for flushing and pressurizing the balloon 120 .

[0038] See also Figure 1-Figure 7 The embodiment of the second aspect of the present invention further provides a blood vessel repair method, wherein the blood vessel repair device 100 of any of the above embodiments, see Figure 7 The vascular repair method includes but is not limited to the following steps: S101: introducing gas into the air inlet pipe 110; S102: Ionize gas to form plasma; S103: mixing the plasma in the inner cavity 123 with physiological saline to form a plasma activation solution; S104 : The plasma activated liquid is made to pass through the second surface 122 along the width direction Y of the blood vessel 200 and reach the endothelium of the blood vessel 200 .

[0039] The above steps are further described below. In step S101, the gas can be introduced by other structures of the vascular repair device 100, or by an external device. In step S102, the method of ionizing the gas and forming plasma can be specifically referred to the relevant description of the first annular electrode 115 and the second annular electrode 116 in the previous embodiment. In step S103, the liquid supply tube 140 described in the previous embodiment can be used to provide physiological saline to the inner cavity 123.

[0040] In step S104 , the plasma activated liquid in the inner cavity 123 may be squeezed toward the endothelium of the blood vessel 200 by pressurizing the balloon 120 .

[0041] Previous studies have shown that active substances contained in plasma at an appropriate concentration, such as active nitrogen substances, can promote the formation of human umbilical vein endothelial cells (HUVEC) tubes; other studies have shown that plasma treatment can promote angiogenesis 200. Therefore, in some embodiments, the gas is nitrogen, so that the plasma is nitrogen plasma.

[0042] The following is a specific implementation of a vascular repair method in an embodiment: the balloon 120 is initially in a deflated state. After the vascular repair device 100 is inserted into the blood vessel 200, physiological saline is injected to prop up the balloon 120, so that part of the balloon 120 can be attached to the blood vessel 200, and the other part is separated from the blood vessel 200 to form a space for blood to flow through. Then nitrogen gas is introduced into the gas guide cavity 114 between the inner tube 111 and the outer tube 112, and the first annular electrode 115 and the second annular electrode 116 discharge together to ionize the gas to generate gaseous plasma. The gaseous plasma passes through the first surface 121 that is air-permeable and water-impermeable, enters the interior of the balloon 120, blends into the physiological saline inside the balloon 120, diffuses and reacts, and forms a plasma activation liquid; since the gas passes through the grid structure after entering the balloon 120, the larger bubbles are broken, forming nano-scale small bubbles; since the introduced nitrogen is not completely ionized to generate plasma, part of the nitrogen directly enters the balloon 120 and passes through the grid, thus forming nitrogen nanobubbles. The plasma activated liquid is pressurized to pass through the water-permeable and air-impermeable second surface 122 and is transported into the blood vessel 200 .

[0043] Thanks to the improvements made to the vascular repair device 100 in the above embodiments, the vascular repair method in the second embodiment of the present invention has the same technical effects as the vascular repair device 100 in the above embodiments, which will not be described in detail here.

[0044] The above are only preferred embodiments of the present invention, and are not intended to limit the patent scope of the present invention. All equivalent structural changes made using the contents of the present invention's specification and drawings, or directly / indirectly applied in other related technical fields, are included in the patent protection scope of the present invention.

Claims

1. A vascular repair device, characterized in that: include: Intake pipe; The balloon comprises a first surface and a second surface, wherein the first surface and the second surface together define an inner cavity, the first surface is configured to allow gas to pass through and to block liquid, and the second surface is configured to allow liquid to partially pass through and to block gas; The air inlet pipe is disposed on one side of the first surface along the length direction of the blood vessel, and the one side of the second surface along the width direction of the blood vessel is suitable for facing the blood vessel.

2. The vascular repair device according to claim 1, characterized in that: The air inlet tube includes an inner tube and an outer tube, the outer tube is sleeved on the outside of the inner tube, the inner tube defines a first guide wire cavity, an air guide cavity is defined between the inner tube and the outer tube, and the air guide cavity is suitable for passing gas. The vascular repair device also includes a guide wire tube, the guide wire tube and the air inlet tube are respectively connected to the two sides of the balloon along the length direction, the guide wire tube defines a second guide wire cavity, the first guide wire cavity and the second guide wire cavity are coaxially arranged and are both suitable for inserting a guide wire for interventional treatment.

3. The vascular repair device according to claim 2, characterized in that: The outer surface of the inner tube is provided with a first annular electrode extending in a circumferential manner, and the inner surface of the outer tube is provided with a second annular electrode extending in a circumferential manner. The first annular electrode and the second annular electrode are configured to ionize the gas in the gas guide cavity and form plasma after being energized.

4. The vascular repair device according to claim 1, characterized in that: The blood vessel repair device also includes an air outlet pipe. Along the length direction of the blood vessel, the first surface is distributed on both sides of the balloon, and the air inlet pipe is penetrated through the first surface on one side, and the air outlet pipe is penetrated through the first surface on the other side.

5. The vascular repair device according to claim 4, characterized in that: The outlet pipe includes a first pipe and a second pipe, the maximum outflow area of ​​the first pipe is S1, the maximum outflow area of ​​the second pipe is S2, the maximum outflow area of ​​the inlet pipe is S3, and the following condition is satisfied: S1+S2≥S3.

6. The vascular repair device according to claim 4, characterized in that: The air inlet tube includes an inner tube and an outer tube, the outer tube is sleeved on the outer side of the inner tube, the inner tube defines a first guide wire cavity, an air guide cavity is defined between the inner tube and the outer tube, and the air guide cavity is suitable for passing gas, the vascular repair device also includes a guide wire tube, the guide wire tube and the air inlet tube are respectively connected to the two sides of the balloon along the length direction, the guide wire tube defines a second guide wire cavity, the first guide wire cavity and the second guide wire cavity are coaxially arranged and are both suitable for inserting a guide wire for interventional treatment; The air outlet tube includes a first tube and a second tube. Along the direction perpendicular to the length direction, the first tube and the second tube are respectively connected to two sides of the balloon, and the guide wire tube is located between the first tube and the second tube.

7. The vascular repair device according to claim 1, characterized in that: Observing along the length direction of the blood vessel, the balloon is elliptical.

8. The vascular repair device according to claim 1, characterized in that: The balloon includes a grid net arranged in the inner cavity, and the grid net faces the air inlet tube along the length direction of the blood vessel.

9. A method for repairing blood vessels, characterized in that: Using the vascular repair device according to any one of claims 1 to 9, the vascular repair method comprises: Passing the gas into the air inlet pipe; ionizing the gas to form a plasma; Mixing the plasma in the inner cavity with the physiological saline to form a plasma activation solution; The plasma activated liquid is made to pass through the second surface along the width direction of the blood vessel and reach the endothelium of the blood vessel.

10. The blood vessel repair method according to claim 9, characterized in that: The gas is nitrogen gas, so that the plasma is nitrogen plasma.

Images