Drug-containing medical dressing, preparation method and packaging device

Abstract

The invention belongs to the technical field of medical dressings, and relates to a medicine-containing medical dressing, a preparation method and a packaging device. The dressing comprises a drug-containing base material and functional liquid, the drug-containing base material is used after being infiltrated by the functional liquid, and has excellent repairing, regenerating, healing promoting and moisturizing properties. The preparation method comprises the following steps: performing spinning forming on raw materials, soaking the raw materials in traditional Chinese medicine liquid containing jade muscle powder and rhizoma atractylodis macrocephalae, and drying to obtain a medicine-containing base material; the preparation method comprises the following steps: firstly adding the thickening agent into purified water, uniformly mixing, then adding the pH regulator, the emulsifier, the humectant and the recombinant collagen, mixing, and regulating the pH value and viscosity to obtain the functional liquid. The preparation method adopts a physical mixing process, the process is simple, and large-scale production is easy to realize. According to the packaging device, the medicine-containing base material and the functional liquid can be subjected to dry-wet separated packaging, and the packaging device is instant in soaking when used and convenient to carry; the cup body of the device is wide in top and narrow in bottom, so that functional liquid can be fully absorbed, waste is avoided, the liquid consumption is reduced, and the product cost is reduced.

Description

Technical Field

[0001] The invention belongs to the technical field of medical dressings, and relates to a medicated medical dressing, a preparation method and a packaging device. Background Art

[0002] With the rise of medical aesthetics, consumers are increasingly accepting of daily medical aesthetics projects such as photoelectric and water-light needles. However, these projects are invasive during the operation, and the skin is in an open state after the operation, requiring external medical dressings to speed up wound repair. The mainstream materials in medical dressings on the market are hyaluronic acid and collagen. Hyaluronic acid has a better moisturizing effect, while collagen focuses on postoperative repair, so it is very popular among consumers. Collagen is a biological polymer and the main component of animal connective tissue. It is also the most abundant and widely distributed functional protein in mammals. There are also recombinant collagen obtained by fermentation and other methods on the market. The price is relatively expensive, so the amount added to various cosmetics and dressings is relatively small; in addition, because this type of product has few additives and concentrated ingredient effects, many consumers will also choose this type of dressing in the daily maintenance of damaged skin barriers, but the packaging is large and not easy to carry.

[0003] In recent years, the development of the Chinese medicine industry has been supported by national policies, and market demand has continued to grow. At the same time, innovation and technological progress have brought new development opportunities to the industry. The modernization of Chinese medicine is not only a continuation of traditional medicine, but also an innovation and development in the field of global health. "Surgery Authentic" records that "Yujisan" is an external Chinese medicine for the treatment of rheumatic freckles, wine thorns, white dandruff, and skin itching. It is generally used as an ointment to apply to the diseased part of the skin. After the improvement, "Yujisan" added white silkworm, polygonatum and coix seed to enhance its efficacy. It is generally used as a mud mask in modern times; Baizhu has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis. Modern pharmacological research also has anti-inflammatory, analgesic, anti-aging and other effects. It is generally used in combination with other Chinese medicines as an internal preparation. However, there is no relevant research on the use of "Yujisan" and Baizhu as external medical dressings. Summary of the invention

[0004] Based on this, the purpose of the present invention is to provide a medicated medical dressing, which has the effects of reducing swelling and relieving pain, antibacterial and anti-inflammatory, promoting wound healing, moisturizing, whitening and brightening, and anti-aging and wrinkle removal.

[0005] The invention also provides a preparation method and a packaging device for the dressing.

[0006] To achieve the above object, the present invention adopts the following technical solutions: The invention provides a medicated medical dressing, comprising a medicated base material and a functional liquid; the drug components of the medicated base material include a mixture of 2-5 parts of Yujisan and 1-3 parts of Atractylodes macrocephala, or a solvent extract of the mixture; the effective components of the functional liquid include recombinant collagen, a moisturizer, an emulsifier, a thickener and a pH regulator; the medicated base material is used after being soaked in the functional liquid; the components are measured in parts by weight.

[0007] Furthermore, the drug-containing substrate is obtained by spinning the raw materials into shape, soaking them in a traditional Chinese medicine solution, and drying them; the raw materials include tencel, cuprammonium fiber, carboxymethyl cellulose, silk or pure cotton fiber; the traditional Chinese medicine solution contains 87-98 parts of purified water, 1-3 parts of non-ionic dispersant and 1-10 parts of drug ingredients; the particle size of the mixture is ≤75μm, and preferably contains 3 parts of Yujisan and 1 part of Atractylodes; the solvent extract contains water extract and alcohol extract, and the water extract and alcohol extract are preferably mixed in a mass ratio of 1:1; the components are measured in parts by weight.

[0008] Furthermore, the Yuji Powder comprises 50-77 parts of mung beans, 4-6 parts of angelica dahurica, 4-10 parts of white aconite root, 3-4 parts of talc, 4-10 parts of white bombyx batryticatus, 4-10 parts of polygonatum odoratum and 4-10 parts of coix seed; the non-ionic dispersant comprises one or more of Tween 20, Tween 80, Span 20, Span 80 or polyethylene glycol; the components are measured in parts by weight.

[0009] Furthermore, the soaking time of the traditional Chinese medicine liquid is 20-40S, and the drying adopts a gradient drying method. The gradient drying process is: the drying temperatures are 50°C, 45°C, and 40°C in sequence, and each period lasts 60±10s.

[0010] Furthermore, the functional liquid contains 90.05-96.87 parts of purified water, 3-9 parts of moisturizer, 0-0.15 parts of emulsifier, 0.05-0.20 parts of pH adjuster, 0.07-0.40 parts of thickener, and 0.01-0.20 parts of recombinant collagen, and the components are calculated in parts by weight.

[0011] Furthermore, the moisturizer includes any one or more of grape seed oil, allantoin, squalane, glycerin, sodium hyaluronate or propylene glycol; the emulsifier includes any one or more of Tween 20, Tween 60, Tween 80 or triethanolamine; the pH adjuster includes any one or more of citric acid, sodium hydroxide or triethanolamine; the thickener includes xanthan gum, carbomer 940 or carbomer 980; the recombinant collagen includes recombinant type III collagen, the molecular weight of which is 49-59KD, preferably medical grade.

[0012] Furthermore, the pH value of the functional liquid is 5-8, and the viscosity is ≤1000mPa.s.

[0013] The present invention also provides a method for preparing a medicated medical dressing, comprising the steps of spinning a raw material into a shape, soaking the raw material in a traditional Chinese medicine solution, and drying the raw material to obtain the medicated base material; first adding a thickener to purified water and mixing the mixture, then adding a pH adjuster, an emulsifier, a moisturizer, and recombinant collagen to mix the mixture, and adjusting the pH value and viscosity to obtain the functional liquid; and packaging the medicated base material and the functional liquid to obtain the medicated medical dressing.

[0014] Furthermore, the preferred mixing method of the thickener in the purified water is stirring and mixing, and the preferred mixing conditions are as follows: temperature of 30-45° C., stirring speed of 150-300 rpm, and time of 30-60 min.

[0015] The present invention further provides a packaging device for packaging the medicated medical dressing of the present invention, comprising a cup body, the cup mouth of the cup body is covered with an easy-tear cover, the surface of the easy-tear cover is covered with a cup cover, a functional liquid holding cavity is formed between the cup body and the easy-tear cover; and a medicated substrate holding cavity is formed between the easy-tear cover and the cup cover.

[0016] Furthermore, the cup body is preferably in the shape of a truncated cone that is wider at the top and narrower at the bottom, the diameter of the tear-away cover is larger than the diameter of the cup mouth, the diameter of the lower edge of the cup cover matches the diameter of the cup mouth, and after being sealed with the cup mouth by threads or snap-fitting, a medicated substrate accommodating cavity is formed between the tear-away cover and the cup mouth.

[0017] Furthermore, the cup body and the cup cover are made of polyethylene (PE); the easy-tear cover includes a composite layered structure, preferably a three-layer structure, which includes a polyethylene terephthalate layer (PET), an aluminum foil layer (Al), and a polyethylene layer (PE) from the outside to the inside.

[0018] Finally, the present invention provides an application of a packaging device in the packaging of medicated medical dressings, which is achieved by filling the functional liquid into the cup body, sealing and sterilizing the cup body with the easy-tear cover, compressing and packaging the medicated substrate, placing it on the easy-tear cover, and covering the cup with the cover.

[0019] Furthermore, the drug-containing base material and the functional liquid are separately packaged, and the separate packaging is preferably a dry-wet separation packaging.

[0020] Furthermore, the sterilization method is preferably electron beam irradiation sterilization, and the sterilization dose is preferably 6-12 KGy.

[0021] The beneficial effects of the present invention are: 1. The medicated medical dressing provided by the present invention has a medicated base material which is spun and soaked in a traditional Chinese medicine solution, then cooled and dried in sections, cut with a cutter of a certain shape, and compressed into a base material with a smaller volume through a compression process, which is convenient for independent packaging; 2. The medicated medical dressing provided by the present invention contains Yujisan and Atractylodes macrocephala in its medicated base material. Yujisan has the effects of dispelling wind and relieving pain, reducing swelling and relieving itching, relieving inflammation and relieving pain, promoting diuresis and removing dampness, anti-aging and antibacterial. Atractylodes macrocephala has the effects of drying dampness and promoting diuresis, and modern pharmacological research also has the effects of whitening and removing spots, promoting wound healing, antibacterial and anti-inflammatory, and moisturizing.

[0022] 3. The functional liquid of the medicated medical dressing provided by the present invention does not contain preservatives, which reduces the risk of skin irritation and allergies. In addition, the functional liquid contains type III collagen, which determines the elasticity and fineness of the skin. Type III collagen has good biological properties and has the effects of promoting wound healing, whitening and brightening, anti-aging and wrinkle removal, and moisturizing.

[0023] 4. The present invention provides a packaging device for medicated medical dressings, which can achieve dry-wet separation of medicated substrates and functional liquids. When in use, it can be soaked immediately to avoid the shedding of Chinese medicine during storage and ensure the biological activity of the effective ingredients; it is also easy to carry and convenient for use in various scenarios such as business trips, travel, and entertainment. The cup body of the device is wide at the top and narrow at the bottom, so that the functional liquid can be fully absorbed, avoiding waste, reducing the amount of functional liquid used, and reducing product costs.

[0024] 5. The present invention provides a packaging device for medicated medical dressings. During the packaging process, only the functional liquid can be sterilized by irradiation, and the medicated substrate does not need to be aseptically treated, thereby fully retaining the efficacy of the effective ingredients of traditional Chinese medicine in the medicated substrate. The medicated medical dressing has the effects of reducing swelling and relieving pain, antibacterial and anti-inflammatory, promoting wound healing, moisturizing, whitening and brightening, and anti-aging and anti-wrinkle.

[0025] 6. The preparation method of the medicated medical dressing provided by the present invention adopts a physical mixing process, has a simple process, and is easy to realize large-scale production. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solution of the present invention, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0027] Attached Figure 1 It is a front view of the packaging device in the present invention; Attached Figure 2It is an exploded view of the components of the packaging device of the present invention when the packaging device contains a medicated medical dressing; Attached Figure 3 It is a cross-sectional view of the packaging device of the present invention when it contains a medicated medical dressing. DETAILED DESCRIPTION

[0028] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. The embodiments mentioned are all implemented on the premise of the technical solutions of the present invention, and detailed implementation processes are given, but it should be stated that the protection scope of the present invention is not limited to the following embodiments.

[0029] The medicated medical dressing provided by the present invention mainly comprises a medicated base material and a functional liquid, and the medicated base material is used after being infiltrated with the functional liquid. The preparation of the medicated medical dressing in the embodiment of the present invention mainly comprises the following process: S1, by spinning Tencel, cuprammonium fiber, carboxymethyl cellulose, silk or pure cotton fiber, the liquid absorption of the substrate membrane obtained after spinning is ≥15mL / g, the square meter mass is ≥20g / square meter, and the thickness is 0.15-0.30mm. The substrate membrane is soaked in the traditional Chinese medicine solution for 20-40S, and the drug-containing substrate is obtained after gradient drying, that is, the temperature is lowered by 50℃, 45℃, and 40℃ in stages, and each section lasts for 60±10s. After drying, it is cut with a cutter of a certain shape, and compressed into a smaller volume through a compression process for easy packaging. The traditional Chinese medicine solution contains 87-98 parts of purified water, 1-3 parts of non-ionic dispersant and 1-10 parts of drug ingredients. The drug ingredients include a mixture of Yujisan and Atractylodes macrocephala, or a solvent extract of the mixture; the components are measured by weight.

[0030] The mixture of Yujisan and Atractylodes macrocephala is an ultrafine powder, the particle size of which is ≤75μm, and contains 3 parts of Yujisan and 1 part of Atractylodes macrocephala. The ultrafine powder can be directly mixed with Yujisan and Atractylodes macrocephala powders of corresponding particle sizes; or Yujisan and Atractylodes macrocephala Chinese medicine slices can be purchased, mixed, crushed with a low-temperature pulverizer, and sieved to obtain the ultrafine powder.

[0031] The solvent extract of the mixture contains water extract and alcohol extract, and the water extract and the alcohol extract are preferably mixed in a mass ratio of 1:1. Weigh 100g of the mixture, add 10 times the amount of purified water, reflux extract at 80°C for 8h, filter, reflux extract 3 times in total, collect the filtrate, and concentrate under reduced pressure to obtain a water extract, and collect the residue at the same time; the residue is reflux extracted 3 times with 8 times the amount of 75% ethanol at 50°C, 2h each time, filter each time, collect the filtrate, and remove the ethanol by distillation under reduced pressure to obtain an alcohol extract.

[0032] Yujisan includes 50-77 parts of mung beans, 4-6 parts of angelica dahurica, 4-10 parts of white aconite, 3-4 parts of talc, 4-10 parts of white bombyx batryticatus, 4-10 parts of polygonatum odoratum and 4-10 parts of coix seed; the non-ionic dispersant includes one or more of Tween 20, Tween 80, Span 20, Span 80 or polyethylene glycol; the components are measured in parts by weight.

[0033] The gradient drying method adopted by the present invention can improve drying efficiency, improve product quality, and save energy and protect the environment. A higher temperature can promote rapid evaporation of water, thereby accelerating the drying speed; a higher temperature is used in the initial stage to quickly remove surface water, and as the drying proceeds, the temperature is gradually reduced to prevent the components from being overheated and damaged; by reasonably utilizing the temperature gradient, energy waste is avoided, and the smooth progress of the drying process is ensured.

[0034] S2, dissolving the thickener in purified water, setting the temperature to 30°C-45°C, the stirring speed to 150-300rpm, and the dissolution time to 30-60min; then adding the pH adjuster, emulsifier, moisturizer, and recombinant collagen in sequence, stirring for 10-30min respectively; adjusting the pH value to 5-8 and the viscosity to ≤1000mPa.s to obtain a functional liquid.

[0035] The functional liquid contains 90.05-96.87 parts of purified water, 3-9 parts of moisturizer, 0-0.15 parts of emulsifier, 0.05-0.20 parts of pH regulator, 0.07-0.40 parts of thickener and 0.01-0.20 parts of recombinant collagen, and the components are calculated in parts by weight.

[0036] The moisturizer includes any one or more of grape seed oil, allantoin, squalane, glycerin, sodium hyaluronate or propylene glycol; the emulsifier includes any one or more of Tween 20, Tween 60, Tween 80 or triethanolamine; the pH adjuster includes any one or more of citric acid, sodium hydroxide or triethanolamine; the thickener includes xanthan gum, carbomer 940 or carbomer 980; and the recombinant collagen includes recombinant type III collagen.

[0037] The pH value of the skin surface is usually between 4.5 and 6.5, which is slightly acidic. This acidic environment helps protect the skin, prevent the invasion of harmful external substances, and maintain the health of the skin; the pH value of functional liquids is usually set between 5-8. This range can ensure that the functional liquid is not too alkaline, thereby avoiding irritation or damage to the skin.

[0038] Appropriate viscosity can make the dressing fit the skin better, reduce the dripping of functional liquid, and ensure that every drop of functional liquid can be fully absorbed by the skin, thereby improving the use effect of the mask. Functional liquid that is too viscous may irritate the skin surface and easily cause skin pores to become clogged.

[0039] S3, prepare the packaging device for dry and wet separation, such as Figure 1-3 As shown, the packaging device for packaging the medicated medical dressing in the present invention includes a cup body, the cup mouth of the cup body is covered with an easy-tear cover, the surface of the easy-tear cover is covered with a cup cover, a functional liquid holding cavity is formed between the cup body and the easy-tear cover; and a medicated substrate holding cavity is formed between the easy-tear cover and the cup cover.

[0040] The preferred cup body is a truncated cone that is wide at the top and narrow at the bottom. The diameter of the tear-away cover is larger than the diameter of the cup mouth. The diameter of the lower edge of the cup cover matches the diameter of the cup mouth. After being sealed with the cup mouth by threads or snap-fitting, a medicated substrate accommodating cavity is formed between the tear-away cover and the cup mouth.

[0041] The preferred cup bottom diameter is 2-3cm, the cup mouth diameter is 3.5-4.5cm, and the cup body height is 2-4cm; the easy-tear cover diameter is 3.55-4.55cm; the cup cover lower edge diameter is 3.5-4.5cm, the cup cover upper edge diameter is 3.3-4.3cm, and the cup cover height is 1-2cm; the cup body thickness is 0.1-0.3cm. The cup body and cup cover are made of polyethylene (PE); the easy-tear cover includes a composite layered structure, preferably a three-layer structure, which is a polyethylene terephthalate layer (PET), an aluminum foil layer (Al), and a polyethylene layer (PE) from the outside to the inside.

[0042] S4, the functional liquid is filled into the cup body by a filling machine, sealed with an easy-tear cover and sterilized; then the drug-containing substrate is compressed and packaged and placed on the easy-tear cover, and finally the cup cover is covered to complete the discrete packaging of the drug-containing medical dressing. The sterilization method is preferably electron beam irradiation sterilization, and the sterilization dose is preferably 6-12KGy.

[0043] The raw materials used in the examples and comparative examples of the present invention can be directly commercially available raw materials.

[0044] Example 1 1) Weigh 60g of the mixture powder, 10g of Span 80 and 15g of Tween 20 respectively, put them into 915g of purified water, stir them with a magnetic stirrer to obtain the Chinese medicine solution; 2) Spinning carboxymethyl cellulose through a certain process to obtain a substrate membrane cloth, soaking the substrate membrane cloth in the traditional Chinese medicine solution of step 1) for 30 seconds, cooling and drying in stages, the temperatures are set to 50°C, 45°C, and 40°C in sequence, and the drying temperature of each stage is 60 seconds, cutting with a cutter of a certain shape, compressing it into a smaller substrate through a compression process, and packaging it in a plastic bag to obtain a drug-containing substrate; 3) Dissolve 0.15g of Carbomer 940 in 91.63g of purified water, set the temperature to 40°C, set the mechanical stirring speed to 200rpm, and the dissolution time to 30min; add 0.11g of triethanolamine, 0.01g of citric acid, 3g of propylene glycol, 5g of glycerol, and 0.1g of recombinant type III collagen in sequence, and stir for 10min to obtain a functional liquid with a pH value of 6.14 and a viscosity of 503mPa.; 4) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized with a 7KGy electron beam; the drug-containing substrate obtained in step 2) is placed on the easy-tear cover, and the cup cover is closed to obtain the drug-containing medical dressing.

[0045] 5) Open the lid of the medicated medical dressing cup in step 4), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0046] Example 2 1) Weigh 20g of the mixture ultrafine powder, 5g of Span 20 and 5g of Tween 80 respectively, put them into 970g of purified water, stir them with a magnetic stirrer to obtain the Chinese medicine solution; 2) Spinning the cuprammonium fiber through a certain process to obtain a substrate membrane cloth, soaking the substrate membrane cloth in the traditional Chinese medicine solution of step 1) for 30 seconds, cooling and drying in stages, the temperatures are set to 50°C, 45°C, and 40°C in sequence, and the drying temperature of each stage is 60 seconds, cutting with a cutter of a certain shape, compressing it into a smaller substrate through a compression process, and packaging it in a plastic bag to obtain a drug-containing substrate; 3) Dissolve 0.2g xanthan gum in 93.53g purified water, set the temperature to 40°C, set the mechanical stirring speed to 150rpm, and the dissolution time to 40min; add 0.1g sodium hydroxide, 0.02g citric acid, 0.1g Tween 80, 1g propylene glycol, 2g sodium hyaluronate, 3g glycerol, and 0.05g recombinant type III collagen in sequence, and stir for 20min to obtain a functional liquid with a pH value of 6.35 and a viscosity of 832mPa.s; 4) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized with an 8KGy electron beam; the drug-containing substrate obtained in step 2) is placed on the easy-tear cover, and the cup cover is closed to obtain the drug-containing medical dressing.

[0047] 5) Open the lid of the medicated medical dressing cup in step 4), take out the medicated substrate, tear off the easy-tear cover, and soak the medicated substrate in a functional liquid to fully infiltrate the cytotoxicity, repair and regeneration, and moisturizing properties.

[0048] Example 3 1) Weigh 40g of the mixture powder, 5g of Span 80 and 10g of Tween 20 respectively, put them into 945g of purified water, stir them with a magnetic stirrer to obtain the Chinese medicine solution; 2) The Tencel is spun through a certain process to obtain a substrate membrane cloth, which is then soaked in the Chinese medicine solution of step 1) for 30 seconds, and then dried in stages with the temperature set to 50°C, 45°C, and 40°C in sequence, with each stage drying at 60 seconds, and then cut with a cutter of a certain shape, compressed into a smaller substrate through a compression process, and packaged in a plastic bag to obtain a drug-containing substrate; 3) Dissolve 0.08g of Carbomer 980 in 93.6g of purified water, set the temperature to 30°C, set the mechanical stirring speed to 150rpm, and the dissolution time to 35min; add 0.06g of triethanolamine, 0.01g of citric acid, 0.1g of Tween 80, 4g of glycerol, 2g of squalane, and 0.15g of recombinant type III collagen in sequence, and stir for 20min to obtain a functional liquid with a pH value of 5.92 and a viscosity of 493mPa.s; 4) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized with a 10KGy electron beam; the drug-containing substrate obtained in step 2) is placed on the easy-tear cover, and the cup cover is closed to obtain the drug-containing medical dressing.

[0049] 5) Open the lid of the medicated medical dressing cup in step 4), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0050] Example 4 1) Weigh 50g of the mixture powder, 5g of Span 20 and 1.5g of Tween 80 respectively, put them into 943.5g of purified water, stir them with a magnetic stirrer to obtain the Chinese medicine solution; 2) Spinning the pure cotton fiber through a certain process to obtain a substrate membrane cloth, soaking the substrate membrane cloth in the traditional Chinese medicine solution of step 1) for 30 seconds, cooling and drying in stages, the temperatures are set to 50°C, 45°C, and 40°C in sequence, and the drying temperature of each stage is 60 seconds, cutting with a cutter of a certain shape, compressing it into a smaller substrate through a compression process, and packaging it in a plastic bag to obtain a drug-containing substrate; 3) Dissolve 0.18g of Carbomer 940 in 91.37g of purified water, set the temperature to 45°C, set the mechanical stirring speed to 200rpm, and the dissolution time to 40min; add 0.13g of triethanolamine, 0.02g of citric acid, 3g of propylene glycol, 5g of glycerol, 0.15g of urea capsule, and 0.15g of recombinant type III collagen in sequence, and stir for 20min to obtain a functional liquid with a pH value of 6.61 and a viscosity of 925mPa.s; 4) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized with a 10KGy electron beam; the drug-containing substrate obtained in step 2) is placed on the easy-tear cover, and the cup cover is closed to obtain the drug-containing medical dressing.

[0051] 5) Open the lid of the medicated medical dressing cup in step 4), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0052] Example 5 1) Weigh 80g of the mixture ultra-fine powder and 30g of polyethylene glycol respectively, put them into 890g of purified water, and mix them by magnetic stirring to obtain the Chinese medicine solution; 2) The silk is spun through a certain process to obtain a substrate membrane cloth, the substrate membrane cloth is soaked in the traditional Chinese medicine solution of step 1) for 30 seconds, and the temperature is lowered and dried in stages, and the temperature is set to 50°C, 45°C, and 40°C in sequence, and the drying temperature of each stage is 60 seconds, and a certain shape of cutter is used for cutting, and a compression process is used to compress it into a smaller substrate, and it is packaged in a plastic bag to obtain a drug-containing substrate; 3) Dissolve 0.35g xanthan gum in 90.84g purified water, set the temperature to 45°C, set the mechanical stirring speed to 200rpm, and the dissolution time to 50min; add 0.15g sodium hydroxide, 0.01g citric acid, 0.5g Tween 80, 3g propylene glycol, 5g grape seed oil, and 0.15g recombinant type III collagen in sequence, and stir for 20min to obtain a functional liquid with a pH value of 6.83 and a viscosity of 958mPa.s; 4) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized with a 10KGy electron beam; the drug-containing substrate obtained in step 2) is placed on the easy-tear cover, and the cup cover is closed to obtain the drug-containing medical dressing.

[0053] 5) Open the lid of the medicated medical dressing cup in step 4), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0054] Example 6 1) Weigh 5g of water extract, 5g of alcohol extract, 1g of Span 80, and 1g of Tween 20 respectively, put them into 988g of purified water, and mix them by magnetic stirring to obtain the Chinese medicine solution; 2) Spinning carboxymethyl cellulose through a certain process to obtain a substrate membrane cloth, soaking the substrate membrane cloth in the traditional Chinese medicine solution of step 1) for 30 seconds, cooling and drying in stages, the temperatures are set to 50°C, 45°C, and 40°C in sequence, and the drying temperature of each stage is 60 seconds, cutting with a cutter of a certain shape, compressing it into a smaller substrate through a compression process, and packaging it in a plastic bag to obtain a drug-containing substrate; 3) Dissolve 0.15g of Carbomer 940 in 91.63g of purified water, set the temperature to 40°C, set the mechanical stirring speed to 200rpm, and the dissolution time to 30min; add 0.11g of triethanolamine, 0.01g of citric acid, 3g of propylene glycol, 5g of glycerol, and 0.1g of recombinant type III collagen in sequence, and stir for 10min to obtain a functional liquid with a pH value of 6.14 and a viscosity of 503mPa.s; 4) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized with a 7KGy electron beam; the drug-containing substrate obtained in step 2) is placed on the easy-tear cover, and the cup cover is screwed on to obtain the drug-containing medical dressing.

[0055] 5) Open the lid of the medicated medical dressing cup in step 4), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0056] Comparative Example 1 1) Spinning the cuprammonium fiber through a certain process to obtain a substrate membrane cloth, cutting the substrate membrane cloth with a cutter of a certain shape, compressing it into a smaller substrate through a compression process, and packaging it in a plastic bag to obtain the substrate; 2) Dissolve 0.15g of Carbomer 940 in 91.63g of purified water, set the temperature to 40°C, set the mechanical stirring speed to 200rpm, and the dissolution time to 30min; add 0.11g of triethanolamine, 0.01g of citric acid, 3g of propylene glycol, 5g of glycerol, and 0.1g of recombinant type III collagen in sequence, and stir for 10min to obtain a functional liquid with a pH value of 6.13 and a viscosity of 518mPa.s; 3) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized by 10KGy electron beam; the substrate obtained in step 1) is placed on the easy-tear cover, and the cup is covered with a lid to obtain a blank medical dressing.

[0057] 4) Open the lid of the medicated medical dressing cup in step 3), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0058] Comparative Example 2 1) Spinning the cuprammonium fiber through a certain process to obtain a substrate membrane cloth, cutting the substrate membrane cloth with a cutter of a certain shape, compressing it into a smaller substrate through a compression process, and packaging it in a plastic bag to obtain the substrate; 2) Dissolve 0.15g of Carbomer 940 in 91.73g of purified water, set the temperature to 40°C, set the mechanical stirring speed to 200rpm, and the dissolution time to 30min; add 0.11g of triethanolamine, 0.01g of citric acid, 3g of propylene glycol, and 5g of glycerol in sequence, and stir for 10min respectively to obtain a functional liquid with a pH value of 6.15 and a viscosity of 513mPa.s; 3) The functional liquid is filled into the cup body in a certain proportion, sealed with an easy-tear cover, and sterilized by 10KGy electron beam; the substrate obtained in step 1) is placed on the easy-tear cover, and the cup is covered with a lid to obtain a blank medical dressing.

[0059] 4) Open the lid of the medicated medical dressing cup in step 3), take out the medicated substrate, tear off the easy-tear cover, soak the medicated substrate in the functional liquid to fully infiltrate it, and then conduct cytotoxicity, repair and regeneration, and moisturizing performance tests.

[0060] Implementation effect analysis The dressings obtained in Examples 1-6 and Comparative Examples 1-2 were tested for cytotoxicity, repair and regeneration, and moisturizing properties. The test results are shown in the following table.

[0061] 1. Cytotoxicity test: The test is carried out in accordance with the standard "GB / T 16886.5-2017 Biological Evaluation of Medical Devices Part 5: In vitro Cytotoxicity Test".

[0062] 2. Repair and regeneration evaluation: This evaluation method is the lactic acid stinging test and the stratum corneum thickness test. The lactic acid stinging test is tested according to the standard "T / BDCA 0005-2023 Cosmetic Soothing Efficacy Test Human Lactic Acid Stinging Test Test Method"; the stratum corneum thickness test is tested using an optical coherence tomography scanner (OCT). Recruit 10 subjects (18-40 years old) for the test and take the average value.

[0063] 3. Moisturizing performance test: According to the standard of "QB / T4256-2011 Cosmetic Moisturizing Efficacy Evaluation Guide", the moisture content of the stratum corneum of the skin was tested using a skin moisture tester. Ten subjects (18-40 years old) were recruited for the test and the average value was taken.

[0064] The data in the table show that compared with the control example in which the substrate was not treated with the Chinese medicine liquid containing Yujisan and Atractylodes macrocephala and no recombinant collagen was added, the test results of the embodiment were better than the control example, and had obvious repair and regeneration, healing ability and moisturizing performance.

[0065] In Examples 1-6, the subjects who used the medicated substrate had a lower lactic acid stinging sensation than those who used the samples of Comparative Examples 1 and 2, and the stratum corneum thickness test results were better than those of the samples of Comparative Examples 1 and 2, that is, after using the medicated substrate containing Yujisan and Atractylodes macrocephala, the repair and regeneration function of the medicated medical dressing was significantly improved; at the same time, the skin water content was better than the comparative example, that is, the moisturizing performance was significantly improved. Therefore, adding recombinant type III collagen and moisturizer to the functional liquid can effectively improve its repair, regeneration and moisturizing performance, while the medicated substrate can significantly improve the repair, regeneration and moisturizing performance of the medicated medical dressing.

[0066] In summary, the medicated medical dressing provided by the present invention comprises Yujisan and Atractylodes macrocephala in its medicated base material. Yujisan has the effects of dispelling wind and relieving pain, reducing swelling and relieving itching, reducing inflammation and relieving pain, promoting diuresis and infiltrating dampness, anti-aging and antibacterial. According to Chinese prescriptions, the ingredients of Yujisan are mung bean, angelica dahurica, white aconite, talc, white silkworm, polygonatum odoratum and coix seed. Among them, mung bean has the effects of clearing away heat and detoxifying, reducing swelling and relieving itching, promoting wound healing and beautifying the skin; angelica dahurica has the effects of dispelling cold, dispelling wind and relieving pain, anti-inflammatory and analgesic, can moisturize the skin, effectively remove spots and pigmentation, and can also dilate blood vessels, effectively improving the symptoms of blood circulation; white aconite has the effects of detoxifying and dispersing knots, sedation, analgesia, anti-inflammatory and antibacterial; talc has the effects of antibacterial and protecting the skin and mucous membranes; white silkworm has the effects of dispelling wind and relieving pain, and modern pharmacological research also has the effects of sedation, antibacterial, whitening and lightening spots; polygonatum odoratum has the effects of nourishing yin and moisturizing dryness, delaying aging and anti-oxidation; coix seed has the effects of promoting diuresis and infiltrating dampness, sedation and analgesia. Atractylodes has the effect of drying dampness and promoting diuresis. Modern pharmacological research also shows that it has the effects of whitening and removing freckles, promoting wound healing, anti-bacterial and anti-inflammatory, and moisturizing.

[0067] The functional liquid of the medicated medical dressing provided by the present invention contains type III collagen, which determines the elasticity and fineness of the skin. Type III collagen has good biological properties and has the effects of promoting wound healing, whitening and brightening, anti-aging and wrinkle removal, and moisturizing.

[0068] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A medicated medical dressing, characterized in that: It comprises a drug-containing base material and a functional liquid; the drug ingredients of the drug-containing base material include a mixture of 2-5 parts of Yujisan and 1-3 parts of Atractylodes macrocephala, or a solvent extract of the mixture; the effective ingredients of the functional liquid include recombinant collagen, a moisturizer, an emulsifier, a thickener and a pH regulator; the drug-containing base material is used after being soaked in the functional liquid; the components are measured in parts by weight.

2. The medicated medical dressing according to claim 1, characterized in that: The drug-containing substrate is obtained by spinning the raw materials into shape, soaking them in traditional Chinese medicine liquid, and drying them; the raw materials include tencel, cuprammonium fiber, carboxymethyl cellulose, silk or pure cotton fiber; the traditional Chinese medicine liquid contains 87-98 parts of purified water, 1-3 parts of non-ionic dispersant and 1-10 parts of drug ingredients; the particle size of the mixture is ≤75μm; the solvent extract contains water extract and alcohol extract; the components are measured by weight.

3. The medicated medical dressing according to claim 2, characterized in that: The Yuji Powder comprises 50-77 parts of mung beans, 4-6 parts of angelica dahurica, 4-10 parts of white aconite root, 3-4 parts of talc, 4-10 parts of white bombyx batryticatus, 4-10 parts of polygonatum odoratum and 4-10 parts of coix seed; the non-ionic dispersant comprises one or more of Tween 20, Tween 80, Span 20, Span 80 or polyethylene glycol; the components are measured in parts by weight.

4. The medicated medical dressing according to claim 2, characterized in that: The soaking time of the traditional Chinese medicine liquid is 20-40 seconds, and the drying adopts a gradient drying method. The gradient drying process is: the drying temperatures are 50° C., 45° C., and 40° C. in sequence, and each period lasts for 60±10 seconds.

5. The medicated medical dressing according to claim 1, characterized in that: The functional liquid contains 90.05-96.87 parts of purified water, 3-9 parts of moisturizer, 0-0.15 parts of emulsifier, 0.05-0.20 parts of pH regulator, 0.07-0.40 parts of thickener, and 0.01-0.20 parts of recombinant collagen, and the components are calculated by weight.

6. The medicated medical dressing according to claim 1, characterized in that: The moisturizer includes any one or more of grape seed oil, allantoin, squalane, glycerin, sodium hyaluronate or propylene glycol; the emulsifier includes any one or more of Tween 20, Tween 60, Tween 80 or triethanolamine; the pH adjuster includes any one or more of citric acid, sodium hydroxide or triethanolamine; the thickener includes xanthan gum, carbomer 940 or carbomer 980; and the recombinant collagen includes recombinant type III collagen.

7. The medicated medical dressing according to claim 1, characterized in that: The pH value of the functional liquid is 5-8, and the viscosity is ≤1000mPa.s.

8. A method for preparing the medicated medical dressing according to any one of claims 1 to 7, characterized in that: The drug-containing base material is obtained by spinning the raw material into shape, soaking it in a traditional Chinese medicine solution, and drying it; the functional liquid is obtained by first adding a thickener to purified water and mixing it, then adding a pH adjuster, an emulsifier, a moisturizer, and recombinant collagen to mix, and adjusting the pH value and viscosity; the drug-containing base material and the functional liquid are packaged to obtain a drug-containing medical dressing.

9. A packaging device, characterized in that: Used to package the medicated medical dressing according to any one of claims 1 to 7, comprising a cup body, the mouth of the cup body is covered with an easy-tear cover, the surface of the easy-tear cover is covered with a cup cover, a functional liquid holding cavity is formed between the cup body and the easy-tear cover; and a medicated substrate holding cavity is formed between the easy-tear cover and the cup cover.

10. Use of the packaging device according to claim 9 in packaging of medicated medical dressings, characterized in that: The functional liquid is filled into the cup body, sealed and sterilized with the easy-tear cover, and then the drug-containing base material is compressed and packaged and placed on the easy-tear cover, and the cup cover is covered to obtain the cup body.

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