Traditional Chinese medicine mud rubbing device, preparation method thereof, micro-throttling mixing-continuous extrusion device and application

Abstract

The invention discloses a traditional Chinese medicine mud rubbing device, a preparation method thereof, a micro-throttling mixing-continuous extrusion device and application, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine mud rubbing device comprises the following components in percentage by mass: 0.05%-5% of traditional Chinese medicine composition extract powder containing coptis chinensis, 1.2%-3.6% of a thickening agent, 0.5%-2.6% of a cutin stripping agent, 1%-10% of a humectant, 0.01%-0.05% of a perfume product and the balance of water. The traditional Chinese medicine mud rubbing agent keeps the advantages of rapid removal of aged cutin, mildness, no damage to skin, rapid mud formation, tender and smooth skin, no adhesion to body hair, easy washing and the like, and on one hand, the effects of inhibiting bacteria, eliminating dampness, relieving itching and the like are added; on the other hand, the viscosity, large foam removal and bubble removal durability of the product are improved, and the mixing uniformity of the medicine is improved, so that the problem of formability is solved.

Description

Technical Field

[0001] The invention relates to a traditional Chinese medicine clay-rubbing treasure and a preparation method thereof, a micro-throttling mixing-continuous extrusion device and application thereof, and belongs to the technical field of traditional Chinese medicine. Background Art

[0002] Skin health and cleanliness are important issues of general concern. The epidermal cells of the human body are constantly undergoing a cyclical renewal process, which includes regeneration, maturation and eventual death. Dead cells will become part of the stratum corneum, while new cells will gradually advance to the surface of the skin. The renewal rate of skin cells is affected by many factors, including eating habits, sleep patterns, emotional state, age, and warm and humid climates. At present, there are many products that have the effect of exfoliating and cleaning the skin. The principles and methods involved include physical methods, such as scrubs and bath salts, which remove keratin through the friction of tiny particles. This method may damage the epidermis due to excessive friction; chemical methods, such as exfoliating gels and fruit acid products, have the effect of dissolving or softening keratin. This method can penetrate deep into the epidermis of the skin, but it may easily cause skin allergies; in addition, there are enzymatic methods, such as protease cleansing and hydration methods, such as exfoliating creams, etc., but these methods take a long time and affect the efficiency of use.

[0003] The rubbing mud treasure, also known as the rubbing mud bath treasure, can quickly penetrate into the tiny grooves, wrinkles and deep pores of the skin with its innovative formula, effectively absorbing and removing stubborn epidermal dirt and aging keratin. Compared with other skin cleansing products, the gentle mechanical exfoliation of the rubbing mud treasure can well protect the skin tissue and has a highly efficient skin exfoliation effect. At present, the rubbing mud treasure may have the following shortcomings: it is difficult to produce mud fragments after repeated rubbing, and the user experience is not good; the mud fragments produced after rubbing are easy to adhere to the body hair and are difficult to rinse. The above technical problems can still be solved by optimizing the formulation prescription, such as the new rubbing mud bath treasure disclosed in CN104546655A and CN104825345A, which can solve the problems of mud and rinsing. However, like other exfoliating cleansing products, the functional design of Chou Ni Bao is somewhat simple. In fact, the functional design can also be targeted at the accompanying problems of skin keratin, such as solving the possible discomfort problems such as rough skin and itching caused by sweat secretions or hot and humid climate factors on the surface of the skin, so as to expand the application value of Chou Ni Bao.

[0004] Chinese medicine cosmetics are products that combine traditional Chinese medicine theory with modern beauty technology. They have become increasingly popular in the market in recent years. Adding extracts of Chinese medicine compositions to skin care products such as Ruo Ni Bao can play a certain role in antibacterial, anti-inflammatory, heat-clearing and detoxification. Its active ingredients can also promote skin metabolism, enhance skin gloss and have skin care functions. Due to the complexity of its ingredients, rheological and hygroscopic properties, the extracts of Chinese medicine compositions will significantly lead to difficulties in molding, different appearance characteristics, odor changes, etc. of Chinese medicine Ruo Ni Bao. The focus needs to be on improving the uniformity of drug mixing and the persistence of degassing. Therefore, there is a lot of room for functional design and molding process design for Chinese medicine Ruo Ni Bao. Summary of the invention

[0005] Aiming at the exfoliating function of toiletries and its expansion needs, the present invention proposes a Chinese medicine mud-rubbing treasure. The core goal of the invention is to enrich the functional scope of the mud-rubbing treasure and provide a solution to the molding problem of the Chinese medicine mud-rubbing treasure, thereby significantly improving the application value of the product. The Chinese medicine mud-rubbing treasure of the present invention maintains the advantages of rapid removal of aged keratin, gentleness without skin damage, rapid mud-raising, smooth skin, no adhesion to body hair, and easy washing. On the one hand, it has the added effects of inhibiting bacteria, drying dampness and relieving itching; on the other hand, it increases the viscosity of the product, removes large foam, removes the persistence of bubbles, improves the uniformity of drug mixing, etc., thereby solving the molding problem.

[0006] Meanwhile, the invention provides a preparation method of a traditional Chinese medicine rubbing mud treasure.

[0007] At the same time, the present invention provides a micro-throttling mixing-continuous extrusion device for a traditional Chinese medicine mud-rubbing treasure, which can significantly improve the uniformity of drug mixing and the persistence of degassing bubbles.

[0008] At the same time, the invention provides an application of a traditional Chinese medicine mud-rubbing treasure.

[0009] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0010] The Chinese medicine mud-rubbing treasure mentioned in the present invention comprises the following components in percentage by mass: 0.05%-5% of powder of a Chinese medicine composition extract containing coptis root, 1.2%-3.6% of a thickener, 0.5%-2.6% of an exfoliating agent, 1%-10% of a moisturizing agent, 0.01%-0.05% of a perfume product, and the remainder is water.

[0011] The extract powder of the Chinese medicinal composition containing coptis root is extracted by a decoction method, decocted twice by adding 8 times the prescribed amount of water, and then vacuum-microwave dried after combining the decoctions.

[0012] A Chinese medicine composition comprises an optimized ratio of coptis chinensis and a Chinese medicine compatible with coptis chinensis, wherein coptis chinensis and a Chinese medicine compatible with coptis chinensis include Chinese medicine pieces, Chinese medicinal materials and Chinese medicinal plants. The naming of Chinese medicine includes the official name, common name, etc.

[0013] Coptis chinensis is a traditional Chinese herbal medicine with significant antibacterial effects. It is widely used to treat a variety of bacterial infection symptoms. Coptis chinensis contains a variety of alkaloids, such as berberine, jatrorrhizine, coptisine and palmatine, which are the main sources of its antibacterial activity. In daily chemical products such as Ruonibao, the addition of extracts of coptis chinensis combined with other Chinese medicines has antibacterial ingredients and can exert a certain antibacterial effect without the need to add additional preservatives.

[0014] The weight percentage of Coptis chinensis leaf extract is 0.05%-5%, for example, it can be 0.05%, 0.10%, 0.2%, 0.4%, 0.6%, 0.8%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, 3.0%, 3.2%, 3.4%, 3.6%, 3.8%, 4.0%, 4.2%, 4.4%, 4.6%, 4.8% or 5.0%, etc., preferably 1.8-4.5%.

[0015] The weight percentage of the thickener is 1.2%-3.6%, for example, it can be 1.2%, 1.4%, 1.6%, 1.8%, 2.0%, 2.2%, 2.4%, 2.6%, 2.8%, 3.0%, 3.2%, 3.4% or 3.6%, etc.

[0016] The weight percentage of the exfoliating agent is 0.5%-2.6%, for example, it can be 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, etc., preferably 2.0%-2.6%.

[0017] The weight percentage of the moisturizer is 1%-10%, for example, it can be 1%, 2%, 3%, 4%, 5%, 6%, 7%, 9% or 10%.

[0018] The weight percentage of the fragrance product is 0.01%-0.05%, for example, it can be 0.01%, 0.02%, 0.03%, 0.04% and 0.05%.

[0019] The following are preferred embodiments of the present invention, but are not intended to limit the technical solutions provided by the present invention. The objectives and beneficial effects of the present invention can be achieved and realized through the following preferred embodiments:

[0020] Preferably, the Chinese medicine composition contains coptis root, Chinese medicine compatible with coptis root, such as pomegranate peel, peony bark, codonopsis pilosula, calamus, etc., which have been experimentally verified to have significant antibacterial and antimicrobial effects.

[0021] Preferably, the thickener is carbomer. Carbomer can produce efficient thickening effect at a very low dosage (conventional dosage 0.25-0.5%), has high stability to temperature changes, and can prepare products with different viscosity ranges and rheological properties. Among them, carbomer 980 has a higher viscosity than carbomer 940, and has better ion resistance and skin care effect.

[0022] Preferably, the exfoliating agent is hexadecyltrimethylammonium chloride.

[0023] Preferably, the moisturizing agent is at least one of butylene glycol, 1,3-propylene glycol and glycerol, or a combination of two or three thereof, preferably a combination of butylene glycol and glycerol.

[0024] Preferably, the spice product can include jasmine essential oil, osmanthus essential oil, freesia essential oil, etc. After evaluation by volunteers, osmanthus essential oil alone is the best. The spice is used to prepare Lianliudan Rubbing Mud Treasure, and then the molding quality is evaluated. According to the formula in Table 1, a total of 0.4 mL of the composite spice product is absorbed into a container, and volunteers (13) are randomly invited to smell the odor lightly and select 1-3 favorite odors, with the one with more votes being the best.

[0025] Table 1 Experimental design of Chinese medicine rubbing mud treasure spice formula

[0026]

[0027] The present invention provides a method for preparing the above-mentioned traditional Chinese medicine rubbing mud treasure, comprising the following steps:

[0028] 1. Prepare the extract solution of the Chinese medicine composition: dissolve the extract powder of the Chinese medicine composition with at least 8 times the amount of preparation water, and filter to remove impurities. The preparation water refers to purified water that can be used for pharmaceutical preparations, such as high-purity water obtained by distillation, ion exchange, reverse osmosis or other appropriate methods;

[0029] 2. Preparation of the aqueous phase: put a thickener and a moisturizer into a container, add the prepared Chinese medicine composition extract solution in step 1, and allow to fully swell for at least 8 hours;

[0030] 3. Preparation of oil phase: Mix the exfoliating agent and the fragrance product in a certain proportion to prepare the oil phase, with or without adding preservatives;

[0031] 4. Micro-throttling mixing-continuous extrusion process: The "micro-throttling mixing-continuous extrusion" device is used to prepare the Chinese medicine mud treasure. The 70℃~80℃ oil phase enters the insulation barrel from the channel entrance, and the 70℃~80℃ water phase enters from the microchannel entrance. Under the extrusion force of the extrusion rod and the piston, it is quickly stirred by the micro homogenizer and then extruded from the extrusion port.

[0032] The pressure rod and the piston can adjust the extrusion pressure. The insulation barrel is a miniature stainless steel barrel with a diameter of 5 to 6 cm, and the outer layer is covered with insulating material to ensure that the water phase and the oil phase have certain rheological properties before extrusion; the diameter of the insulation barrel is larger than the diameter of the extrusion port, which can play a good role in throttling and controlling flow. The diameter of the channel entrance is about 1 to 1.2 cm, which is suitable for the passage of oil phase with higher viscosity, and can be used with an ordinary peristaltic pump to achieve continuous pumping of the oil phase; the inner diameter of the microchannel entrance (5) is 3 mm to 4 mm, which is suitable for the passage of water phase with lower viscosity, and can be used with an ordinary peristaltic pump to achieve continuous addition of the water phase.

[0033] The micro homogenizer is a spherical cavity with a diameter of about 2 to 2.5 cm. A specially designed stirring paddle is embedded in the spherical cavity. Each blade of the stirring paddle has a left edge and a right edge, and both the left edge and the right edge are spiral (double helix structure); the angle between the lower edge of the blade and the horizontal plane is 25 to 35 degrees. The 6 blades are combined together to form a spherical shape without a central axis, which can simultaneously realize the horizontal rotation mixing and up and down tumbling movement of the material, so that the water phase and the oil phase are mixed more quickly. The stirring paddle is driven by a transmission gear, and the power of the transmission gear can be provided by a low-power motor.

[0034] A micro-throttling mixing-continuous extrusion device for a traditional Chinese medicine mud-rubbing treasure comprises a heat-insulating drum, a piston is built in the heat-insulating drum, an extrusion rod is connected to the top of the piston, a channel inlet of 1 to 1.2 cm is arranged on the side wall of the heat-insulating drum, a pipeline with an inner diameter of 1 to 1.2 cm is connected to the bottom of the heat-insulating drum, a micro-channel inlet with an inner diameter of 3 to 4 mm is connected to the side wall of the pipeline, a micro-homogeneous mixer is arranged on the pipeline below the micro-channel inlet, and the bottom end of the pipeline is an extrusion port.

[0035] The micro homogenizer is a spherical cavity with an inner diameter of 2 to 2.5 cm. A stirring paddle is hinged in the spherical cavity. Each blade of the stirring paddle has a left edge and a right edge. Both the left edge and the right edge are spiral, that is, a double spiral structure. The angle between the lower edge of the stirring paddle and the horizontal plane is 25 to 35 degrees. The 6 blades are combined together to form a spherical shape without a central axis. The stirring paddle is driven by a transmission gear, and the power of the transmission gear is provided by an electric motor.

[0036] The insulation drum is a miniature stainless steel drum with a diameter of 5 to 6 cm, and the outer layer is covered with insulating material;

[0037] The channel inlet and the microchannel inlet are both connected to a peristaltic pump, which is powered by a power supply.

[0038] A Chinese medicine mud-rubbing treasure is used in the preparation of a Chinese medicine mud-rubbing treasure that can quickly remove aged keratin, is mild and does not hurt the skin, quickly creates mud, makes the skin tender and smooth, does not adhere to body hair, is easy to rinse, inhibits bacteria, dries dampness and relieves itching, removes bubbles for a long time, and improves the uniformity of drug mixing.

[0039] As the preparation process of the traditional Chinese medicine Ruonibao of the present invention is optimized, compared with the existing Ruonibao process, many beneficial effects are produced:

[0040] Preferably, the Chinese medicine mud preparation device and process are carried out in a closed environment, and the air in the device is discharged by using the volume of the material itself. Therefore, no air will be introduced during the preparation process, thereby achieving a defoaming effect and preventing volatile components (such as spices or volatile oils, etc.) from volatilizing.

[0041] Preferably, by controlling the flow rates of the oil phase channel and the water phase channel, the content of the Chinese medicinal materials in the Ruonibao can be accurately controlled; by continuously pumping in the materials, continuous and uninterrupted industrial production can be achieved with high production efficiency.

[0042] Preferably, the diameter of the heat-insulating drum of the "micro-throttling mixing-continuous extrusion" device is about 5 to 6 cm, which can meet the needs of experiments and production. When used in process research experiments, it can prevent the waste of raw materials caused by the failure of large-scale feeding experiments in traditional processes.

[0043] Preferably, micro-stirring is adopted, and the stirring paddle blade adopts an arc-shaped micro double-helix structure design, which can make the material rotate and stir in the horizontal direction and tumble in the vertical direction, so that the Chinese medicine material is mixed more evenly.

[0044] Preferably, the micro stirring paddle adopts a decentralized shaft design, in order to reduce the resistance when the material is extruded.

[0045] Preferably, the micro-stirring paddle removes the central axis of the traditional stirring paddle, and secondly, it is more convenient and efficient to clean, and prevents the centrifugal force of the central axis from approaching 0N, which makes it impossible to effectively remove the sticking effect of the material.

[0046] In addition, since the device occupies a small volume, multiple identical devices can be combined and one pump can be used for multiple channels. Flexible assembly can meet different production needs. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 It is a schematic structural diagram of the micro-throttling mixing-continuous extrusion device of the present invention;

[0048] Figure 2 for Figure 1 A top view of

[0049] Figure 3 for Figure 1 Right view of;

[0050] Figure 4 It is a schematic structural diagram of a micro homogenizing mixer of the present invention;

[0051] Figure 5 It is a schematic diagram of the structure of the stirring paddle of the present invention;

[0052] Figure 6 for Figure 5 A top view of

[0053] Figure 7 for Figure 5 Stereoscopic image of

[0054] Figure 8 It is a schematic diagram of the structure of the blades of the stirring paddle of the present invention;

[0055] Fig. 9 It is a structural schematic diagram of the angle between the lower edge of the blade of the stirring paddle of the present invention and the horizontal plane;

[0056] Fig.10 It is the response surface result of the antibacterial effect of the present invention;

[0057] Fig.11 The antibacterial effect diagram of the Lianliudan extract with different prescription amounts of the present invention;

[0058] Fig.12 This is an appearance evaluation of the Lianliudan Mud Rubbing Treasure of the present invention, wherein A: a top view of the Lianliudan Mud Rubbing Treasure; B: a front view of the Lianliudan Mud Rubbing Treasure; Figure C: the state of the Lianliudan Mud Rubbing Treasure before use; D: the state of the Lianliudan Mud Rubbing Treasure after use; E: the state of the Lianliudan Mud Rubbing Treasure after standing at six temperatures (-20℃, 4℃, 25℃, 40℃, 50℃, 60℃) for 24h and centrifuging. DETAILED DESCRIPTION

[0059] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. The following embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0060] Example 1

[0061] A Chinese medicine mud-rubbing treasure, namely, Coptis chinensis mud-rubbing treasure, comprises the following components in percentage by weight:

[0062]

[0063] The coptis root composition contains: 30g coptis root, 20g calamus, 10g eucommia, 10g codonopsis, 10g wormwood, 10g sophora flavescens, 10g liquorice, 10g mint, 10g honeysuckle, and 10g jasmine.

[0064] The preparation method of the extract powder of the Chinese medicinal composition containing Coptis chinensis is as follows: the extract is extracted by decoction method, 8 times of the prescribed amount of water is added and decocted twice, and the decoctions are combined and then vacuum microwave dried to obtain the extract.

[0065] The preparation process of Chinese medicine rubbing mud treasure is as follows:

[0066] (1) The water extract powder of the traditional Chinese medicine composition was dissolved in 8 times the amount of purified water, and then filtered to remove impurities after ultrasonic treatment for 10 minutes. The filtrate was added to the thickener and moisturizer, fully swollen for 8 hours, and then heated to 70°C and stirred until uniform, as the water phase.

[0067] (2) Mix the exfoliating agent and the fragrance product, heat to 70°C and stir evenly to prepare the oil phase.

[0068] (3) Micro-throttling mixing-continuous extrusion process: Applications such as Figure 1 to Figure 3 The micro-throttling mixing-continuous extrusion device is shown to prepare a Chinese medicine mud-rubbing treasure. The 70°C oil phase enters the heat-insulating barrel 3 from the channel inlet 4, the bottom of the heat-insulating barrel 3 is connected to a pipe with an inner diameter of 1 cm, and the pipe is connected to a micro-channel inlet 5. The 70°C water phase enters from the micro-channel inlet 5, and under the extrusion force of the extrusion rod 1 and the piston 2, it is quickly stirred by the micro-homogeneous mixer 6, and then extruded from the outlet 7. After thickening, it is cooled to room temperature to obtain a Chinese medicine mud-rubbing treasure.

[0069] The pressure rod 1 and the piston 2 can adjust the extrusion force. The insulation barrel 3 is a miniature stainless steel barrel with a diameter of 5 cm, and the outer layer is covered with insulating material to ensure that the water phase and the oil phase have certain rheological properties before extrusion; the diameter of the insulation barrel is larger than the diameter of the extrusion port, which can play a good role in throttling and controlling the flow. The diameter of the channel inlet 4 is about 1 cm, which is suitable for the passage of the oil phase with higher viscosity, and can be used with an ordinary peristaltic pump to achieve continuous pumping of the oil phase; the inner diameter of the microchannel inlet 5 is about 3 mm, which is suitable for the passage of the water phase with lower viscosity, and can be used with an ordinary peristaltic pump to achieve continuous addition of the water phase.

[0070] like Figures 4 to 7 As shown, the micro homogenizer 6 is a spherical cavity 62 with a diameter of about 2 cm, and a specially designed stirring paddle 63 is embedded in the spherical cavity 62. Figure 8-Figure 9 As shown, each blade of the stirring paddle 63 has a left edge and a right edge, both of which are spiral (double spiral structure), and the angle between the lower edge of the blade of the stirring paddle 63 and the horizontal plane is 25-35°, preferably 30°. The six blades are combined together to form a spherical shape without a central axis, which can simultaneously realize the rotation and mixing of the materials in the horizontal direction and the tumbling movement up and down, so that the water phase and the oil phase are mixed more quickly. The stirring paddle is driven by the transmission gear 61, and the power of the transmission gear can be provided by a low-power motor.

[0071] The Chinese medicine mud-rubbing treasure of this embodiment is used in the preparation of a Chinese medicine mud-rubbing treasure that can quickly remove aged keratin, is gentle and does not hurt the skin, quickly creates mud, makes the skin smooth and tender, does not adhere to body hair, is easy to rinse, inhibits bacteria, dries dampness and relieves itching, removes bubbles for a long time, and improves the uniformity of drug mixing.

[0072] Example 2

[0073] This embodiment provides a traditional Chinese medicine rubbing mud treasure, namely Lianliudan rubbing mud treasure, which includes the following components in percentage by weight:

[0074]

[0075] The Chinese medicine composition (Lianliudan) contains: 20g of Coptis chinensis, 24.53g of pomegranate peel, 30g of peony bark, 10g of Eucommia ulmoides, 10g of Codonopsis pilosula, 10g of Artemisia argyi, 10g of Schisandra chinensis, and 10g of Licorice.

[0076] The preparation process of Chinese medicine rubbing mud treasure is as follows:

[0077] (1) Dissolve the powder of Lianliudan water extract in 10 times the amount of purified water, treat with ultrasound for 20 minutes, and then filter to remove impurities. Add the filtrate to the thickener and moisturizer, fully swell for 10 hours, and then heat to 80°C and stir until uniform, as the water phase.

[0078] (2) Mix the exfoliating agent and the fragrance product, heat them to 80°C and stir them evenly to prepare the oil phase.

[0079] (3) Micro-throttling mixing-continuous extrusion process: Applications such as Figure 1 to Figure 3 The micro-throttling mixing-continuous extrusion device is shown to prepare a Chinese medicine mud-rubbing treasure. The 80°C oil phase enters the heat-insulating barrel 3 from the channel inlet 4, the bottom of the heat-insulating barrel 3 is connected to a pipe with an inner diameter of 1.2 cm, and the pipe is connected to a micro-channel inlet 5. The 80°C water phase enters from the micro-channel inlet 5, and under the extrusion force of the extrusion rod 1 and the piston 2, it is quickly stirred by the micro-homogeneous mixer 6, and then extruded from the outlet 7. After thickening, it is cooled to room temperature to obtain a Chinese medicine mud-rubbing treasure.

[0080] The pressure rod 1 and the piston 2 can adjust the extrusion force. The insulation barrel 3 is a miniature stainless steel barrel with a diameter of 6 cm, and the outer layer is covered with insulating material to ensure that the water phase and the oil phase have certain rheological properties before extrusion; the diameter of the insulation barrel is larger than the diameter of the extrusion port, which can play a good role in throttling and controlling the flow. The diameter of the channel inlet 4 is about 1.2 cm, which is suitable for the passage of the oil phase with a higher viscosity, and can be used with an ordinary peristaltic pump to achieve continuous pumping of the oil phase; the inner diameter of the microchannel inlet 5 is about 4 mm, which is suitable for the passage of the water phase with a lower viscosity, and can be used with an ordinary peristaltic pump to achieve continuous addition of the water phase.

[0081] like Figures 4 to 9As shown, the micro homogenizer 6 is a spherical cavity 62 with a diameter of about 2.5 cm, and a specially designed stirring paddle 63 is embedded in the spherical cavity 62. Each blade of the stirring paddle 63 has a left edge and a right edge, and the left edge and the right edge are both spiral (double helix structure). The angle between the lower edge of the blade of the stirring paddle 63 and the horizontal plane is 25 to 35°, preferably 25°. The 6 blades are combined together to form a spherical shape without a central axis, which can simultaneously realize the rotation mixing of the material in the horizontal direction and the tumbling motion up and down, so that the water phase and the oil phase are mixed more quickly. The stirring paddle is driven by the transmission gear 61, and the power of the transmission gear can be provided by a low-power motor.

[0082] Optimization and formability evaluation

[0083] (1) Optimization of antibacterial effect of Chinese herbal medicine extracts

[0084] The response surface method was used to select the best antibacterial prescription. The response surface group design is shown in Table 2. Among them, -1, 0, and 1 represent low, medium, and high dose groups, respectively; only the dosage of Coptis chinensis (main drug), Paeonia suffruticosa (minister drug), and Pomegranate peel (minister drug) was investigated. The other drugs in the Lianliudan composition were all adjuvant drugs. The low, medium, and high doses of the three Chinese medicines were 10g, 20g, and 30g, respectively.)

[0085] Table 2 Response surface screening of antibacterial effect of Lianliudan composition formula

[0086]

[0087]

[0088] Inhibition zone test (punch method): Add 200 μL of bacterial solution to the plate, sterilize it by burning it with an applicator over the flame of an alcohol lamp, and after cooling, evenly spread the bacterial solution with an applicator.

[0089] Activation of Staphylococcus aureus strains: For the first activation of freeze-dried powder, shake the powder to the bottom, disinfect the tip with alcohol and knock it open, take 0.2-0.3mL of dissolved solution and add it to the strain tube, gently flick until the powder is evenly mixed, use a sterile pipette to suck out all the dissolved solution, and inoculate all of it on two inclined surfaces for culture. Place it in an aerobic environment at 37℃ and culture it for 24-48 hours. It can be used when the strain grows. (Note: Once the vacuum strain tube is knocked open, all the freeze-dried powder inside must be used)

[0090] Preparation of bacterial solution: Use an inoculation loop to pick up two loops of colonies from the slant culture medium and add them to 1 mL of ultrapure water and mix well.

[0091] Use a cork puncher to punch holes in the culture medium. Add 40 μL of ultrapure water to the blank control well, 40 μL of 1 μg / mL sodium penicillin solution to the positive control well, and 40 μL of the test drug solution to the drug well. Incubate at 37°C for 24 hours. Observe and use a vernier caliper to measure the size of the inhibition zone. Measure the diameter (mm) of each inhibition zone separately, and the edge of the inhibition zone is defined as the absence of obvious bacterial growth. All operations were performed under sterile conditions. The results are shown in Table 3. Fig.11 shown.

[0092] Table 3 Antibacterial zone diameters of different dosages of Lianliudan extracts

[0093]

[0094]

[0095] like Fig.10 As shown, the fitting equation is: Y = 59.05-2.60125A + 7.69750B + 5.12C + 8.2AB + 4.7575AC - 3.385A2 - 5.6475C2 - 7.8475A2B,

[0096] R2=0.9863 (Y: antibacterial effect; A: amount of coptis root added; B: amount of peony bark added; C: amount of pomegranate peel added). According to the response surface equation, the best prescription for antibacterial effect was screened out as follows: coptis root 20g; peony bark 30g; pomegranate peel 24.53g; the antibacterial effect was 67.91%.

[0097] (2) Evaluation of the molding quality of Chinese medicine clay treasure

[0098] Lianliudan mud-rubbing treasure was prepared with osmanthus essential oil. The viscosity, mud-raising property, odor, spreadability, and residual feeling were used as indicators to evaluate the stickiness of the mud-rubbing treasure sample when used on the skin, the difficulty of repeatedly rubbing to produce strips of mud, the comfort of skin odor, the difficulty and uniformity of spreading, and the residual degree of the skin sample after washing with water. The quantitative scoring method and results are shown in Table 4. The appearance is as follows Fig.12 The score of the Chinese medicine rubbing mud treasure of Example 2 is 80.50±4.20, and the rubbing mud treasure has moderate consistency, good rubbing mud property, excellent cleaning performance, a smell close to fragrance and comfort, good spreadability, clear and no residual feeling. In addition, the appearance shows no bubbles or few bubbles.

[0099] Table 4 Evaluation indexes and scores of Lianliudan Crush Ni Bao

[0100]

[0101]

[0102] The Chinese medicine mud-rubbing treasure of this embodiment is used in the preparation of a Chinese medicine mud-rubbing treasure that can quickly remove aged keratin, is gentle and does not hurt the skin, quickly creates mud, makes the skin smooth and tender, does not adhere to body hair, is easy to rinse, inhibits bacteria, dries dampness and relieves itching, removes bubbles for a long time, and improves the uniformity of drug mixing.

[0103] Comparative Example 1

[0104] The difference between this comparative example and Example 2 is only that:

[0105] The preparation process of Chinese medicine rubbing mud treasure is as follows:

[0106] (1) Dissolve the powder of Lianliudan water extract in 10 times the amount of purified water, treat with ultrasound for 20 minutes, and then filter to remove impurities. Add the filtrate to the thickener and moisturizer, fully swell for 10 hours, and then heat to 80°C and stir until uniform, as the water phase.

[0107] (2) Heat the exfoliant to 80° C. and stir evenly, then slowly add the 80° C. water phase while hot and stir continuously, then drop osmanthus essential oil into it, and cool it to room temperature after thickening to obtain a traditional Chinese medicine mud-rubbing treasure.

[0108] Comparative Example 2

[0109] The difference between this comparative example and Example 2 is that each blade of the stirring paddle has two edges, left and right, and only one edge is in a spiral shape, that is, the stirring paddle of this comparative example is a single spiral structure.

[0110] Comparative Example 3

[0111] The only difference between this comparative example and Example 2 is that the stirring paddle is spherical as a whole and has a central axis.

[0112] Comparative Example 4

[0113] The only difference between this comparative example and Example 2 is that the diameter of the channel inlet is 0.9 cm; the inner diameter of the microchannel inlet is 2 mm; and the inner diameter of the pipeline is 0.9 cm.

[0114] The mud bags obtained in Comparative Examples 1 to 4 were evaluated as shown in Table 5.

[0115] Comparative Example 1 scored 8 points for consistency, 13 points for mud rubbing, 10 points for odor, 3 points for spreadability, 3 points for residual feeling, and a total score of 37 points.

[0116] Comparative Example 2 scored 15 points for consistency, 22 points for mud rubbing, 18 points for odor, 5 points for spreadability, 6 points for residual feeling, and a total score of 66 points.

[0117] Comparative Example 3 scored 14 points for consistency, 23 points for mud rubbing, 17 points for odor, 6 points for spreadability, 8 points for residual feeling, and a total score of 68 points.

[0118] Comparative Example 4 scored 11 points for consistency, 21 points for mud rubbing, 18 points for odor, 7 points for spreadability, 8 points for residual feeling, and a total score of 65 points.

[0119] It should be understood that in order to streamline the present disclosure and aid in understanding one or more of the various inventive aspects, in the above description of exemplary embodiments of the present invention, various features of the present invention are sometimes grouped together into a single embodiment, figure, or description thereof. However, this disclosed method should not be interpreted as reflecting the intention that the claimed invention requires more features than those expressly recited in each claim. Rather, as reflected in the claims, inventive aspects lie in less than all of the features of the previously disclosed embodiments. Therefore, the claims that follow the detailed description are hereby expressly incorporated into the detailed description, with each claim itself serving as a separate embodiment of the present invention.

[0120] Although the present invention has been described according to a limited number of embodiments, it will be apparent to those skilled in the art, with the benefit of the above description, that other embodiments may be envisioned within the scope of the invention thus described. In addition, it should be noted that the language used in this specification is selected primarily for readability and teaching purposes, rather than for explaining or defining the subject matter of the present invention. Therefore, many modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the appended claims. The disclosure of the present invention is illustrative, not restrictive, with respect to the scope of the present invention, which is defined by the appended claims.

[0121] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine mud-rubbing treasure, characterized in that: The invention comprises the following components in percentage by mass: 0.05%-5% of extract powder of a Chinese medicinal composition containing coptis root, 1.2%-3.6% of a thickener, 0.5%-2.6% of a keratin peeling agent, 1%-10% of a moisturizing agent, 0.01%-0.05% of a perfume product, and the balance is water.

2. A Chinese medicine mud-rubbing treasure according to claim 1, characterized in that: The extract powder of the Chinese medicinal composition containing Coptis chinensis includes the following medicinal materials in parts by weight: 30g Coptis chinensis, 20g Acorus calamus, 10g Eucommia ulmoides, 10g Codonopsis pilosula, 10g Artemisia argyi, 10g Sophora flavescens, 10g Licorice, 10g Mint, 10g Honeysuckle, and 10g Jasmine.

3. A Chinese medicine mud-rubbing treasure according to claim 1, characterized in that: The extract powder of the Chinese medicinal composition containing Coptis chinensis includes the following medicinal materials in parts by weight: 20g Coptis chinensis, 24.53g pomegranate peel, 30g peony bark, 10g Eucommia ulmoides, 10g Codonopsis pilosula, 10g Artemisia argyi, 10g Schisandra chinensis, and 10g Licorice.

4. A Chinese medicine mud-rubbing treasure according to claim 2 or 3, characterized in that: The preparation method of the extract powder of the Chinese medicinal composition containing coptis root is as follows: extracting by decoction method, adding 8 times of the prescribed amount of water and decoct twice, combining the decoctions and performing vacuum microwave drying to obtain the extract.

5. A Chinese medicine mud-rubbing treasure according to claim 1, characterized in that: The thickener is carbomer; the exfoliating agent is hexadecyltrimethylammonium chloride; the moisturizing agent is at least one of butylene glycol, 1,3-propylene glycol, and glycerin, or a combination of two or three; the fragrance product is at least one of jasmine essential oil, osmanthus essential oil, and freesia essential oil, or a combination of two or three.

6. The method for preparing the Chinese medicine rubbing mud treasure according to claim 1, characterized in that: The following steps are involved: S01, preparation of aqueous phase: dissolve the extract powder of the Chinese medicine composition containing Coptis chinensis with at least 8 times the amount of preparation water, perform ultrasonic treatment for at least 10 minutes, filter and remove impurities, add the filtrate to the thickener and moisturizer, fully swell for more than 8 hours, and then heat to 70-80°C and stir until uniform; S02, preparation of oil phase: mixing the exfoliating agent and the fragrance product, heating to 70-80° C. and stirring evenly to prepare the oil phase; S03, micro-throttling mixing-continuous extrusion process: using a micro-throttling mixing-continuous extrusion device to prepare the Chinese medicine mud treasure; The oil phase at 70-80°C enters the heat-insulating drum (3) from the channel inlet (4), and the water phase at 70-80°C enters from the microchannel inlet (5), and is rapidly stirred by the micro homogenizer (6) under the extrusion force of the extrusion rod (1) and the piston (2), and then extruded from the extrusion port (7); The inner diameter of the channel entrance (4) is 1 to 1.2 cm; The inner diameter of the microchannel inlet (5) is 3-4 mm.

7. The micro-throttling mixing-continuous extrusion device of a traditional Chinese medicine rubbing mud treasure according to claim 1 is characterized in that: The invention comprises a heat-insulating drum (3), wherein a piston (2) is built in the heat-insulating drum (3), the top end of the piston (2) is connected to an extrusion rod (1), a channel inlet (4) of 1 to 1.2 cm is arranged on the side wall of the heat-insulating drum (3), a pipe with an inner diameter of 1 to 1.2 cm is connected to the bottom of the heat-insulating drum (3), a micro-channel inlet (5) with an inner diameter of 3 to 4 mm is connected to the side wall of the pipe, a micro-homogenizing mixer (6) is arranged on the pipe below the micro-channel inlet (5), and the bottom end of the pipe is an extrusion port (7).

8. The micro-throttling mixing-continuous extrusion device for a Chinese medicine rubbing mud treasure according to claim 7, characterized in that: The micro homogenizer (6) is a spherical cavity (62) with an inner diameter of 2 to 2.5 cm. A stirring paddle (63) is hinged in the spherical cavity (62). Each blade of the stirring paddle (63) has a left edge and a right edge. Both the left edge and the right edge are in a spiral shape, i.e., a double spiral structure. The angle between the lower edge of the blade and the horizontal plane is 25 to 35 degrees. The six blades are combined together to form a spherical shape without a central axis. The stirring paddle (63) is driven by a transmission gear (61), and the power of the transmission gear (61) is provided by an electric motor.

9. The micro-throttling mixing-continuous extrusion device of a Chinese medicine rubbing mud treasure according to claim 7, characterized in that: The heat-insulating drum (3) is a miniature stainless steel drum with a diameter of 5 to 6 cm and an outer layer covered with insulating material; The channel inlet (4) and the microchannel inlet (5) are both connected to a peristaltic pump, and the peristaltic pump is powered by a power supply.

10. The use of a Chinese medicine mud-rubbing treasure according to claim 1 in preparing a Chinese medicine mud-rubbing treasure that can quickly remove aged keratin, is gentle and does not hurt the skin, quickly creates mud, makes the skin smooth and tender, does not adhere to body hair, is easy to rinse, inhibits bacteria, dries dampness and relieves itching, removes bubbles for a long time, and improves the uniformity of drug mixing.

Images