Intelligent drug delivery system

Abstract

The embodiment of the invention provides an intelligent drug delivery system. The intelligent drug delivery system comprises an MCU control unit, a motor, a drug release pump, a drug storage device and a central venous pressure measuring device. The motor is electrically connected with the MCU control unit, and the output end of the motor is connected with the drug release pump; the liquid medicine input end of the medicine release pump is communicated with the medicine storage device, and the liquid medicine output end of the medicine release pump is communicated with an intravenous injection catheter for intravenous drip of a patient; the signal output end of the central venous pressure measuring device is electrically connected with the MCU through the pressure transmitter. According to the technical scheme, the central venous pressure of a patient is obtained in real time and fed back to the MCU control unit, when the measured value reaches the preset value, the MCU control unit sends a signal to the motor so as to drive the drug release pump to be started and send out a preset amount of drug, and therefore automatic drug delivery is achieved. According to the technical scheme, the dosing opportunity is more accurate, the health of a patient is better facilitated, and meanwhile the working intensity of medical staff is relieved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to an intelligent drug delivery system. Background Art

[0002] During the treatment of heart failure, patients need to use diuretics to excrete the fluid retained in the body through the kidneys. This is suitable for patients with moderate to severe heart failure. The central venous pressure (CVP), a pressure-replacement capacity indicator, is detected to reflect the capacity status in real time (pressure is measured, which reflects capacity. Pressure is linearly related to capacity, and excessive capacity will lead to increased pressure). Diuretics are used accurately according to the capacity status to excrete excess fluid from the body and maintain fluid balance to achieve the purpose of treating heart failure. In the prior art, the method of timed and quantitative drug delivery is commonly used, that is, the nursing staff orally or intravenously injects a quantitative diuretic (such as furosemide or torsemide) into the patient at predetermined intervals.

[0003] In the process of implementing the present invention, the inventors found that there are at least the following problems in the prior art:

[0004] Although this method of manually timing drug delivery is simple, the drug delivery interval is manually determined, which may not completely match the actual needs of patients. There may be a problem that the interval between two doses is too long or too short, so the accuracy is poor. Therefore, how to accurately control the drug delivery time is a problem that needs to be solved. Summary of the invention

[0005] The embodiment of the present invention provides an intelligent drug delivery system to solve the problem in the prior art that the drug delivery time cannot be accurately controlled.

[0006] To achieve the above-mentioned purpose, an embodiment of the present invention provides an intelligent drug delivery system, including an MCU control unit, a motor, a drug release pump, a drug reservoir, and a central venous pressure measuring device for real-time measurement of the patient's central venous pressure; the motor is electrically connected to the MCU control unit, and the output end of the motor is connected to the drug release pump; the drug liquid input end of the drug release pump is connected to the drug reservoir, and the drug liquid output end of the drug release pump is connected to an intravenous injection catheter used for intravenous drip of the patient; the signal output end of the central venous pressure measuring device is electrically connected to the MCU control unit through a pressure transmitter.

[0007] Furthermore, the drug release pump is a peristaltic pump; the peristaltic pump includes a peristaltic tube, the input end of the peristaltic tube extends into the drug reservoir, and the output end of the peristaltic tube is connected to the intravenous injection catheter.

[0008] Furthermore, the drug release pump includes a drug release cartridge and a screw assembly; the drug release cartridge includes a cylinder body and a piston sleeved on the inner side of the cylinder body, and the piston can move in the cylinder body along the axial direction; the screw assembly includes a screw and a screw nut that can move along the axial direction of the screw, the input end of the screw is connected to the motor, the screw nut is connected to the guide rod, and the end of the guide rod is connected to the end of the piston; the cylinder body is provided with a drug inlet port and a drug outlet port, the drug inlet port is connected to the drug storage device, and the drug outlet port is connected to the intravenous injection catheter.

[0009] Furthermore, the intelligent drug delivery system also includes a position sensor for limiting the extreme position of the lead screw nut, and the position sensor is electrically connected to the MCU control unit.

[0010] Furthermore, a ventilation valve is arranged on the top of the medicine storage container, and a filter layer is arranged inside the ventilation valve.

[0011] Furthermore, the medicine storage device is provided with a liquid level sensor, and the liquid level sensor is electrically connected to the MCU control unit.

[0012] Furthermore, a motor drive module and a speed detection circuit are provided between the motor and the MCU control unit.

[0013] Furthermore, a flow rate detection circuit is provided between the drug release pump and the MCU control unit.

[0014] Furthermore, the intelligent drug delivery system also includes an audible and visual alarm electrically connected to the MCU control unit.

[0015] Furthermore, the intelligent drug delivery system also includes a button and an LED screen, and the button and the LED screen are electrically connected to the MCU control unit respectively.

[0016] The above technical solution has the following beneficial effects:

[0017] In the present technical solution, the central venous pressure of the patient is obtained in real time through a central venous pressure measuring device, and the central venous pressure is fed back to the MCU control unit. When the measured value reaches the preset value, the MCU control unit gives a start signal to the motor, so that the motor drives the drug release pump and delivers a predetermined amount of medicine, thereby realizing automatic drug administration. Compared with the manual regular drug administration method in the prior art, the drug administration time of the present technical solution is determined by the patient's central venous pressure measurement value rather than manual subjective judgment. Therefore, the drug administration time is controlled more accurately and is more beneficial to the patient's health. In addition, the automatic drug administration method also reduces the workload of medical staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a schematic diagram of the composition of an intelligent drug delivery system according to an embodiment of the present invention;

[0020] Figure 2 is a schematic diagram of a first implementation of a drug release pump in an embodiment of the present invention;

[0021] Figure 3 is a schematic diagram of a second implementation of a drug release pump in an embodiment of the present invention;

[0022] Figure numbers: 1. Pressure transmitter; 2. Sound and light alarm; 3. Button; 4. LED screen; 5. MCU control unit; 6. Motor drive module; 7. Speed ​​detection circuit; 8. Flow rate detection circuit; 9. Power module; 10. Motor; 11. Drug release pump; 12. Drug reservoir; 13. Liquid level sensor; 14. Lithium battery; 15. Power interface; 16. Intravenous catheter; 17. Central venous pressure measuring device; 18. Peristaltic tube; 19. Extrusion chamber; 20. First check valve; 21. Three-way connector; 22. Breathing valve; 23. Dosing port; 24. Screw; 25. Screw nut; 26. Guide rod; 27. Piston; 28. Cylinder; 29. ​​Second check valve; 30. Drug outlet port; 31. Cavity; 32. Drug inlet port; 33. Third check valve; 34. Position sensor. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0024] like Figure 1As shown, an embodiment of the present invention provides an intelligent drug delivery system, including an MCU control unit 5, a motor 10, a drug release pump 11, a drug reservoir 12, and a central venous pressure measuring device 17 for real-time measurement of the patient's central venous pressure; the motor 10 is electrically connected to the MCU control unit 5, and the output end of the motor 10 is connected to the drug release pump 11; the drug liquid input end of the drug release pump 11 is connected to the inner cavity of the drug reservoir 12, and the drug liquid output end of the drug release pump 11 is connected to an intravenous injection catheter 16 for intravenous drip to the patient; the signal output end of the central venous pressure measuring device 17 is electrically connected to the MCU control unit 5 through the pressure transmitter 1.

[0025] The inventors have found that the timing and dosage of diuretic administration can be determined by detecting the patient's central venous pressure, and there is a direct correlation between the two. Further research has found that a better implementation is: when the central venous pressure exceeds 6mmHg, 10mg of torsemide is administered. Therefore, as long as the patient's central venous pressure is monitored in real time, when the central venous pressure reaches the preset value (6mmHg), the MCU control unit 5 gives a start signal to the motor 10, so that the motor 10 drives the drug release pump 11 and delivers a predetermined amount of medicine (the liquid in the drug reservoir 12 is the pre-diluted diuretic torsemide), and the diuretic can be automatically administered. In this way, the administration time is determined by the actual measured value of the patient's central venous pressure, rather than by manual subjective judgment, so the administration time is controlled very accurately, and this automatic administration method can also reduce the workload of medical staff.

[0026] The drug release pump 11 can be in various forms. In a first embodiment, the drug release pump 11 is a metering pump that can be used in the medical industry. A more preferred solution is that the drug release pump 11 is a peristaltic pump. A peristaltic pump is a pump that compresses a peristaltic tube 18 to push the flow of liquid. The pumping speed is controllable, and the delivered liquid does not contact the parts in the pump (this can prevent the drug liquid from being contaminated). Therefore, it is very suitable for the delivery of drug liquid. Its structure is as follows Figure 2 As shown, it includes a pump body, a plurality of rollers rotating along the central axis in the pump body, and a peristaltic tube 18. The input end of the peristaltic tube 18 extends into the drug reservoir 12, and the output end of the peristaltic tube 18 is connected to the intravenous catheter 16 through the first check valve 20. Its working process is as follows: when the measurement result of the central venous pressure measuring device 17 is sent to the MCU control unit 5 via the pressure transmitter 1, if the MCU control unit 5 determines that medication is required according to the preset conditions, a start signal is given to the motor 10, thereby driving the pump shaft to rotate, and a plurality of rollers fixedly connected to the outside of the pump shaft begin to rotate, sucking the drug solution in the drug reservoir 12 into the peristaltic tube 18 (the drug solution should fill the entire peristaltic tube 18 in advance), and as the roller rotates, the roller compresses the peristaltic tube 18 and causes the extrusion chamber 19 to move along the length direction of the peristaltic tube 18, so that the drug solution in the tube is squeezed (see Figure 2The roller is pushed into the extrusion chamber 19 and the liquid medicine in the extrusion chamber 19 is finally discharged from the outlet of the pipeline when the roller rotates continuously. Then, the liquid medicine in the extrusion chamber 19 is mixed into the intravenous injection liquid through the three-way connector 21 and enters the patient's body along the intravenous injection catheter 16. According to the predetermined relationship between the rotation speed and the flow rate, the time required for the peristaltic pump to work during each drug delivery process can be determined. When the time reaches the set value, the MCU control unit 5 gives a stop signal to stop the peristaltic pump to avoid over-delivery of the drug. In addition, in order to accurately control the output of the liquid medicine, the motor 10 should be able to stop and brake quickly. For this purpose, a servo motor can be selected.

[0027] In order to better achieve accurate quantitative measurement of the drug, the second embodiment of the drug release pump 11 is as follows Figure 3 As shown, the drug release pump 11 includes a drug spraying cartridge and a screw assembly; the drug spraying cartridge includes a barrel 28 and a piston 27 sleeved on the inner side of the barrel 28, and the piston 27 can move in the barrel 28 along the axial direction (preferably, the drug spraying cartridge is arranged in the vertical direction), and a cavity 31 for accommodating liquid medicine is formed between the bottom surface of the piston 27 and the bottom surface of the barrel 28; the screw assembly includes a screw 24 and a screw nut 25 that can move along the axial direction of the screw 24, the input end of the screw 24 is connected to the motor 10, the screw nut 25 is connected to the guide rod 26, and the end of the guide rod 26 is connected to the end of the piston 27; the barrel 28 is provided with a drug inlet port 32 and a drug outlet port 30, the drug inlet port 32 is connected to the drug reservoir 12, and the drug outlet port 30 is connected to the intravenous injection catheter 16.

[0028] The working process is as follows: when the MCU control unit 5 issues an action command, the motor 10 drives the screw 24 to rotate forward, and the screw nut 25 threadedly connected to the screw 24 will not rotate with it due to the limitation of the limit mechanism (not shown in the figure), but will move downward along the axis direction of the screw 24, thereby driving the guide rod 26 to move downward synchronously and pushing the piston 27 to move, so that the volume of the cavity 31 becomes smaller, and the liquid medicine in the cavity 31 is squeezed out from the drug outlet port 30, and then mixed into the intravenous injection liquid through the three-way connector 21, and enters the patient's body along the intravenous injection catheter 16. In this process, due to the action of the third check valve 33, the liquid medicine will not return to the drug storage container 12 from the drug inlet port 32. In the screw assembly, the movement stroke of the screw nut 25 corresponding to each rotation of the screw 24 is fixed, so it is easy to accurately control the position of the screw nut 25 by starting and stopping the motor 10, and the screw nut 25 can be self-locked at any position on the screw 24, so it is very suitable for accurate control of drug administration.

[0029] In actual application, in order to meet the rotation speed requirement, a reducer needs to be configured between the motor 10 and the screw rod 24 .

[0030] Furthermore, the intelligent drug delivery system also includes a position sensor 34 for detecting the extreme position of the screw nut 25. The position sensor 34 can be fixed to the side of the screw 24 by a bracket or the like, and is electrically connected to the MCU control unit 5. The position sensor 34 can be in the form of a photoelectric sensor or the like, and its function of detecting whether the lead screw nut 25 has reached the preset limit position is: the medicine reservoir 12 can be designed to accommodate the amount of liquid medicine for multiple injections, and the preset limit position corresponds to the volume of the cavity 31 of a single injection dose. When the lead screw nut 25 crosses the limit position during the movement along the lead screw 24 during drug spraying, it means that the liquid medicine in the cavity 31 is too small at this time, and the remaining amount of medicine after completing the current injection is insufficient to cope with the next quantitative injection. At this time, a signal should be fed back to the MCU control unit 5. The MCU control unit 5 will give a signal after the current drug spraying (the motor 10 rotates forward) is completed, so that the motor 10 drives the lead screw 24 to rotate in the opposite direction, so that the volume of the cavity 31 increases. At this time, the liquid medicine in the medicine reservoir 12 will be replenished into the cavity 31 to ensure that the liquid medicine is sufficient for the next injection; when the lead screw nut 25 does not cross the preset limit position, it means that the liquid medicine in the cavity 31 is sufficient to meet at least one quantitative injection. For example, after the medicine reservoir 12 is filled with liquid medicine, it can accommodate 550 mL of liquid medicine (assuming that after the diuretic is diluted, each 100 mL of liquid medicine contains 10 mg of the diuretic torsemide), and 100 mL is injected each time. During the first four injections, the screw nut 25 did not reach the position of the position sensor 34, and during the fifth injection, the screw nut 25 triggered the position sensor 34. After the fifth injection is completed (at this time, there is still 50 mL of liquid medicine left in the cavity 31. The purpose of this design is to try to ensure that a small amount of liquid medicine remains in the cavity 31 after the last injection, so as to avoid the piston 27 from moving downward excessively in an accidental situation, causing its bottom surface to collide with the bottom surface of the cylinder 28, thereby causing damage to the equipment), the motor 10 will drive the screw 24 to reverse to replenish the medicine (the time interval between two injections of the patient is usually relatively long, and the time interval is much longer than the time of the replenishing operation, so the operation of replenishing the medicine into the medicine barrel will not affect the patient's treatment). During the replenishing process, due to the action of the second check valve 29, the intravenous injection fluid will not be reversely drawn back into the medicine barrel. At the same time, in order to prevent the piston 27 from moving upward excessively during the medicine replenishing operation, a second position sensor (not shown in the figure) can be arranged above the position sensor 34. When the second position sensor is triggered by the lead screw nut 25, the lead screw 24 stops rotating immediately by feeding back a signal to the MCU control unit 5. The position at this time also corresponds to the full load state of the medicine reservoir 12.

[0031] Furthermore, a breathable valve 22 is provided on the top of the drug storage container 12 to allow the atmosphere inside and outside the container to communicate, making it easier for the drug release pump 11 to extract the drug solution. In order to avoid contamination of the drug solution, a filter layer should be provided inside the breathable valve 22.

[0032] Furthermore, the medicine reservoir 12 is provided with a liquid level sensor 13, which is electrically connected to the MCU control unit 5, and the drug delivery system further includes an audible and visual alarm 2 which is electrically connected to the MCU control unit 5. When the liquid medicine in the medicine reservoir 12 is too low, a signal is fed back to the MCU control unit 5 through the liquid level sensor 13, and then a warning is issued through the audible and visual alarm 2, reminding the medical staff to replenish the medicine in the medicine reservoir 12 through the medicine adding port 23 in time. If the medicine reservoir 12 has not been replenished with liquid medicine, the audible and visual alarm 2 continues to alarm and is locked, that is, the MCU control unit 5 cannot give a signal to the motor 10 to avoid accidents.

[0033] Furthermore, a motor driving module 6 and a speed detection circuit 7 are provided between the motor 10 and the MCU control unit 5 to ensure that the speed of the motor 10 meets the expected requirements.

[0034] Furthermore, a flow rate detection circuit 8 is provided between the drug release pump 11 and the MCU control unit 5, such as a flow meter and a matching flow meter signal processing circuit, to verify the actual output volume of the drug solution.

[0035] Furthermore, the intelligent drug delivery system further includes a button 3 and an LED screen 4, which can realize the setting and realization of specific functions, such as adjusting the speed of the motor 10 and fine-tuning the output amount each time. The button 3 and the LED screen 4 are electrically connected to the MCU control unit 5 respectively.

[0036] Furthermore, the intelligent drug delivery system also includes a power module 9 for supplying power to the motor 10 and the MCU control unit 5 . The power module 9 is electrically connected to the lithium battery 14 , and the lithium battery 14 is connected to the power interface 15 .

[0037] In the above detailed description, various features are grouped together in a single embodiment to simplify the disclosure. This method of disclosure should not be interpreted as reflecting an intention that the embodiments of the claimed subject matter require more features than are clearly stated in each claim. On the contrary, as reflected in the appended claims, the invention is in a state of having less than all the features of the disclosed individual embodiments. Therefore, the appended claims are hereby expressly incorporated into the detailed description, with each claim standing on its own as a separate preferred embodiment of the invention.

[0038] The disclosed embodiments are described above to enable any person skilled in the art to implement or use the present invention. Various modifications of these embodiments are obvious to those skilled in the art, and the general principles defined herein may also be applied to other embodiments without departing from the spirit and scope of the present disclosure. Therefore, the present disclosure is not limited to the embodiments given herein, but is consistent with the broadest scope of the principles and novel features disclosed in this application.

[0039] The specific implementation methods described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific implementation method of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An intelligent drug delivery system, characterized in that: The invention comprises an MCU control unit (5), a motor (10), a drug release pump (11), a drug reservoir (12), and a central venous pressure measuring device (17) for measuring the central venous pressure of a patient in real time; the motor (10) is electrically connected to the MCU control unit (5), and the output end of the motor (10) is connected to the drug release pump (11); the drug liquid input end of the drug release pump (11) is connected to the drug reservoir (12), and the drug liquid output end of the drug release pump (11) is connected to an intravenous injection catheter (16) for intravenous dripping of the patient; and the signal output end of the central venous pressure measuring device (17) is electrically connected to the MCU control unit (5) via a pressure transmitter (1).

2. The intelligent drug delivery system according to claim 1, characterized in that: The drug release pump (11) is a peristaltic pump; the peristaltic pump comprises a peristaltic tube (18), the input end of the peristaltic tube (18) extends into the drug storage container (12), and the output end of the peristaltic tube (18) is connected to the intravenous injection catheter (16).

3. The intelligent drug delivery system according to claim 1, characterized in that: The drug release pump (11) comprises a drug spraying cartridge and a screw assembly; the drug spraying cartridge comprises a barrel (28) and a piston (27) sleeved on the inner side of the barrel (28), and the piston (27) can move in the barrel (28) along the axial direction; the screw assembly comprises a screw (24) and a screw nut (25) that can move along the axial direction of the screw (24), the input end of the screw (24) is connected to the motor (10), the screw nut (25) is connected to the guide rod (26), and the end of the guide rod (26) is connected to the end of the piston (27); the barrel (28) is provided with a drug inlet port (32) and a drug outlet port (30), the drug inlet port (32) is connected to the drug storage device (12), and the drug outlet port (30) is connected to the intravenous injection catheter (16).

4. The intelligent drug delivery system according to claim 3, characterized in that: It also includes a position sensor (34) for limiting the extreme position of the screw nut, and the position sensor (34) is electrically connected to the MCU control unit (5).

5. The intelligent drug delivery system according to claim 1, characterized in that: A ventilation valve (22) is also provided on the top of the medicine storage container (12), and a filter layer is provided inside the ventilation valve (22).

6. The intelligent drug delivery system according to claim 1, characterized in that: The medicine storage device (12) is provided with a liquid level sensor (13), and the liquid level sensor (13) is electrically connected to the MCU control unit (5).

7. The intelligent drug delivery system according to claim 1, characterized in that: A motor drive module (6) and a rotation speed detection circuit (7) are also provided between the motor (10) and the MCU control unit (5).

8. The intelligent drug delivery system according to claim 1, characterized in that: A flow rate detection circuit (8) is also provided between the drug release pump (11) and the MCU control unit (5).

9. The intelligent drug delivery system according to claim 1, characterized in that: It also includes an audible and visual alarm (2) electrically connected to the MCU control unit (5).

10. The intelligent drug delivery system according to claim 1, characterized in that: It also includes a button (3) and an LED screen (4), wherein the button (3) and the LED screen (4) are electrically connected to the MCU control unit (5) respectively.

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