Traditional Chinese medicine antibacterial composition based on paulownia flower extract and silver birch extract

Abstract

The invention relates to the technical field of traditional Chinese medicine bacteriostasis, in particular to a traditional Chinese medicine bacteriostatic composition based on a paulownia flower extract and a silver birch extract. Comprising 10-30 parts of a paulownia flower extract, 10-30 parts of a silver birch extract, 10-30 parts of spina date seeds, 5-20 parts of honeysuckle flowers, 5-15 parts of fructus forsythiae, 10-25 parts of radix scutellariae, 5-15 parts of dandelions, 5-15 parts of herba houttuyniae, 1-5 parts of licorice roots and 2-3 parts of a surfactant. The composition has the beneficial effects that efficient bacteriostasis is achieved, specifically, the composition with the efficient bacteriostasis effect is formed by scientifically proportioning the paulownia flower extract, the silver birch extract and other multiple traditional Chinese medicine ingredients. The composition can generate a remarkable inhibition effect on various pathogenic bacteria, and a new choice is provided for treating various diseases caused by the pathogenic bacteria; compared with traditional antibiotics, the traditional Chinese medicine antibacterial composition provided by the invention has lower toxicity. The components are all from natural plants, are harmless to human bodies, and are not easy to generate drug resistance in the use process.

Description

Technical Field

[0001] The invention relates to the technical field of antibacterial drugs of traditional Chinese medicines, and in particular to a antibacterial drug composition of traditional Chinese medicines based on paulownia flower extract and birch tree extract. Background Art

[0002] In the existing field of oral antibacterial technology, although a variety of antibacterial products or methods have been widely used, with the increasing number of pathogens and the gradual increase in drug resistance, the effectiveness of traditional oral antibacterial products has gradually shown limitations. The oral cavity is an important part of the human body. It is not only closely related to the health of the whole body, but also a gathering place for many pathogens. Common oral problems such as caries, periodontal disease, oral ulcers, etc. are often caused or aggravated by pathogens.

[0003] Traditional oral antibacterial products, such as mouthwash and toothpaste, can inhibit the growth of oral pathogens to a certain extent, but their antibacterial ingredients are mostly chemically synthesized substances, which may have adverse effects on the human body if used for a long time, and the drug resistance of pathogens is also becoming increasingly serious. Therefore, the development of new, efficient, low-toxic and non-resistant oral antibacterial products has become a hot topic in current research.

[0004] Paulownia flower and birch tree are common plant resources in nature, and their extracts have broad application prospects in the field of traditional Chinese medicine. Paulownia flower extract is rich in a variety of active ingredients, and has a variety of pharmacological effects such as antitussive, expectorant, and antiasthmatic. At the same time, its negative charge characteristics can effectively inhibit the adhesion of certain pathogens. Ingredients such as betulin in birch extract have antiviral and hair quality improvement activities, and also show negative charge characteristics, which help to inhibit the adhesion of pathogens. However, the current application of paulownia flower extract and birch extract in oral antibacterial is relatively rare, and there is a lack of systematic research and development.

[0005] Therefore, we propose a traditional Chinese medicine antibacterial composition based on Paulownia flower extract and birch extract to solve the above problems. Summary of the invention

[0006] In view of the problems existing in the prior art, the present invention discloses a traditional Chinese medicine antibacterial composition based on paulownia flower extract and birch extract. The technical scheme adopted is that the traditional Chinese medicine antibacterial composition comprises, by weight, 10-30 parts of paulownia flower extract, 10-30 parts of birch extract, 10-30 parts of spiny jujube seeds, 5-20 parts of honeysuckle, 5-15 parts of forsythia, 10-25 parts of scutellaria, 5-15 parts of dandelion, 5-15 parts of houttuynia cordata, 1-5 parts of licorice and 2-3 parts of a surfactant.

[0007] As a preferred technical solution of the present invention, the traditional Chinese medicine antibacterial composition includes, by weight, 10 parts of Paulownia flower extract, 10 parts of white birch extract, 10 parts of Ziziphus jujuba seeds, 5 parts of honeysuckle, 5 parts of Forsythia suspensa, 10 parts of Scutellaria baicalensis, 5 parts of Taraxacum officinale, 5 parts of Houttuynia cordata, 1 part of Licorice and 2 parts of surfactant.

[0008] As a preferred technical solution of the present invention, the traditional Chinese medicine antibacterial composition includes, by weight, 20 parts of Paulownia flower extract, 20 parts of white birch extract, 20 parts of Ziziphus jujuba seeds, 15 parts of honeysuckle, 10 parts of Forsythia suspensa, 15 parts of Scutellaria baicalensis, 10 parts of Taraxacum officinale, 10 parts of Houttuynia cordata, 3 parts of licorice and 2.5 parts of surfactant.

[0009] As a preferred technical solution of the present invention, the traditional Chinese medicine antibacterial composition includes, by weight, 30 parts of Paulownia flower extract, 30 parts of white birch extract, 30 parts of Ziziphus jujuba seeds, 20 parts of honeysuckle, 15 parts of Forsythia suspensa, 25 parts of Scutellaria baicalensis, 15 parts of Taraxacum officinale, 15 parts of Houttuynia cordata, 5 parts of licorice and 3 parts of surfactant.

[0010] As a preferred technical solution of the present invention, the surfactant is selected from one or more combinations of cetylpyridinium chloride, sodium benzoate, sodium lauryl sulfate, potassium sorbate, sodium lauroyl sarcosinate, propylparaben, betaine, hydrogenated castor oil, methylparaben, benzalkonium bromide, and cetylpyridinium chloride.

[0011] As a preferred technical solution of the present invention, the Chinese medicinal antibacterial composition based on Paulownia flower extract and birch extract is prepared by the following process, specifically by the following steps:

[0012] S1. Extracting effective ingredients from Paulownia flowers by water extraction at a temperature of 95 degrees Celsius for 2 hours, and performing multiple extractions until the extraction is complete;

[0013] S2, extracting the corresponding extracts from Paulownia flower and birch bark by water extraction, the extraction temperature is 100 degrees Celsius, the time is 1 hour, and multiple extractions are performed until the extraction is complete;

[0014] S3, mixing Semen Ziziphi Spinosae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Taraxaci, Herba Houttuyniae, Radix Glycyrrhizae and surfactant according to the above weight parts, extracting effective ingredients by the same extraction method, and mixing them evenly with Paulownia flower extract and birch extract;

[0015] S4, the mixed extract is concentrated, dried, and crushed into powder, and the powdered Chinese herbal antibacterial extract is stored.

[0016] In the Chinese medicinal antibacterial composition based on Paulownia flower extract and birch tree extract of the present invention, the effects and functions of each component are as follows:

[0017] Paulownia flower extract: It can relieve cough and asthma by inhibiting central nervous system activity. It is suitable for treating cough symptoms caused by colds, bronchitis, etc.1. In addition, the volatile oil components in Paulownia flower extract can stimulate the secretion of respiratory mucosa, promote sputum discharge, and help relieve symptoms such as lung heat cough and excessive yellow and thick sputum.

[0018] Birch extract: Betulin, a product extracted from birch bark, is also known as betulin, betulin, and betulin. It has antiviral, inhibits protein dissolution in hair fibers, improves the gloss of damaged hair, and promotes hair growth. It can be used in food, cosmetics, medicine and other fields.

[0019] Chinese jujube kernel: Chinese jujube kernel is sweet, sour and flat in nature. It enters the liver, gallbladder and heart meridians. Chinese jujube kernel has the effects of nourishing the heart and liver, calming the mind, astringing sweat and promoting body fluid.

[0020] Honeysuckle: The medicinal property is sweet and cold, and it enters the lung, stomach, and large intestine meridians. Honeysuckle is sweet and cold, clearing and dispersing, and it enters the lung, stomach, and large intestine meridians. It is good at clearing away heat and toxicity, and it is also good at dispersing wind-heat.

[0021] Forsythia suspensa: It is bitter and slightly cold in nature, and enters the lung, heart, and small intestine meridians. Its bitterness can disperse, its slight coldness can clear, and it is light in nature and floats upward, entering the lung, heart, and small intestine meridians.

[0022] Scutellaria baicalensis: Scutellaria baicalensis is bitter and cold in nature, and enters the lung, gallbladder, spleen, large intestine and small intestine meridians. Scutellaria baicalensis is bitter, cold, clearing and drying, and mainly enters the lung and large intestine meridians, and also enters the gallbladder, spleen and stomach meridians.

[0023] Dandelion: bitter, sweet, cold, enters the liver and stomach meridians, clears away heat and detoxifies, reduces swelling and resolves stagnation, and is a diuretic and relieving stranguria.

[0024] Houttuynia cordata: Houttuynia cordata is pungent and slightly cold, and enters the lung and bladder meridians. Houttuynia cordata is pungent and fragrant, and is slightly cold and can clear away heat, and enters the lung and bladder meridians.

[0025] Licorice: Licorice is sweet and neutral in nature, and enters the heart, lung, spleen, and stomach meridians. Licorice is sweet, nourishing, and moisturizing. It is cool when raw, and warm when roasted. It mainly enters the spleen and lung meridians, and also enters the stomach and heart meridians.

[0026] Both birch bark extract and tung flower extract exhibit negative charge properties, and these negatively charged surfaces can effectively inhibit the adhesion of Porphyromonas gingivalis (Pg bacteria).

[0027] Negative charge characteristics of birch bark extract: Birch bark extract contains phenolic substances. These phenolic compounds contain hydroxyl groups and can form negative ions in aqueous solution, showing negative charge characteristics.

[0028] Negative charge characteristics of tung flower extract: The polyphenol compounds in tung flower extract also contain phenolic hydroxyl groups. These groups can release hydrogen ions to form negative ions, making the tung flower extract negatively charged.

[0029] Regulatory effect of negative charge on bacterial adhesion: Negatively charged surfaces can significantly inhibit the adhesion of Porphyromonas gingivalis, while positive charge may promote its adhesion.

[0030] Beneficial effects of the present invention:

[0031] 1. Highly effective antibacterial effect: The present invention forms a Chinese medicine antibacterial composition with high-efficiency antibacterial effect by scientifically proportioning Paulownia flower extract, birch extract and other Chinese medicine ingredients. The composition can produce significant inhibitory effects on a variety of oral pathogens, effectively alleviating or preventing oral problems caused by pathogens;

[0032] 2. Low toxicity: Compared with traditional antibiotics, the Chinese medicine antibacterial composition provided by the present invention has lower toxicity, and its ingredients are all derived from natural plants, are harmless to the human body, and are not easy to produce drug resistance during use;

[0033] 3. Multi-component synergistic effect: The Chinese herbal antibacterial composition of the present invention not only contains Paulownia flower extract and birch extract, but also contains a variety of Chinese herbal ingredients such as Ziziphus jujuba seeds, honeysuckle, forsythia, scutellaria, dandelion, houttuynia cordata and licorice. These ingredients work together in combination to exert antibacterial effects, thereby improving the overall effect of the composition;

[0034] 4. Negative charge characteristics enhance the antibacterial effect: Both Paulownia flower extract and birch extract exhibit negative charge characteristics. These negatively charged surfaces can effectively inhibit the adhesion of pathogens, further enhancing the antibacterial effect of the composition.

[0035] 5. The Chinese herbal antibacterial composition provided by the present invention is prepared by water extraction, which has a simple process, is easy to operate, and can ensure the effectiveness and stability of the extract. DETAILED DESCRIPTION

[0036] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0037] Embodiment 1

[0038] The invention discloses a traditional Chinese medicine antibacterial composition based on paulownia flower extract and birch extract. The technical scheme adopted is that the traditional Chinese medicine antibacterial composition comprises, by weight, 10 parts of paulownia flower extract, 10 parts of birch extract, 10 parts of spiny jujube seeds, 5 parts of honeysuckle, 5 parts of forsythia, 10 parts of scutellaria, 5 parts of dandelion, 5 parts of houttuynia cordata, 1 part of liquorice and 2 parts of surfactant.

[0039] As a preferred technical solution of the present invention, the surfactant is selected from one or more combinations of cetylpyridinium chloride, sodium benzoate, sodium lauryl sulfate, potassium sorbate, sodium lauroyl sarcosinate, propylparaben, betaine, hydrogenated castor oil, methylparaben, benzalkonium bromide, and cetylpyridinium chloride.

[0040] As a preferred technical solution of the present invention, the Chinese medicinal antibacterial composition based on Paulownia flower extract and birch extract is prepared by the following process, specifically by the following steps:

[0041] S1. Extracting effective ingredients from Paulownia flowers by water extraction at a temperature of 95 degrees Celsius for 2 hours, and performing multiple extractions until the extraction is complete;

[0042] S2, extracting the corresponding extracts from Paulownia flower and birch bark by water extraction, the extraction temperature is 100 degrees Celsius, the time is 1 hour, and multiple extractions are performed until the extraction is complete;

[0043] S3, mixing Semen Ziziphi Spinosae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Taraxaci, Herba Houttuyniae, Radix Glycyrrhizae and surfactant according to the above weight parts, extracting effective ingredients by the same extraction method, and mixing them evenly with Paulownia flower extract and birch extract;

[0044] S4, the mixed extract is concentrated, dried, and crushed into powder, and the powdered Chinese herbal antibacterial extract is stored.

[0045] Embodiment 2

[0046] As a preferred technical solution of the present invention, the traditional Chinese medicine antibacterial composition includes, by weight, 20 parts of Paulownia flower extract, 20 parts of white birch extract, 20 parts of Ziziphus jujuba seeds, 15 parts of honeysuckle, 10 parts of Forsythia suspensa, 15 parts of Scutellaria baicalensis, 10 parts of Taraxacum officinale, 10 parts of Houttuynia cordata, 3 parts of licorice and 2.5 parts of surfactant.

[0047] As a preferred technical solution of the present invention, the surfactant is selected from one or more combinations of cetylpyridinium chloride, sodium benzoate, sodium lauryl sulfate, potassium sorbate, sodium lauroyl sarcosinate, propylparaben, betaine, hydrogenated castor oil, methylparaben, benzalkonium bromide, and cetylpyridinium chloride.

[0048] As a preferred technical solution of the present invention, the Chinese medicinal antibacterial composition based on Paulownia flower extract and birch extract is prepared by the following process, specifically by the following steps:

[0049] S1. Extracting effective ingredients from Paulownia flowers by water extraction at a temperature of 95 degrees Celsius for 2 hours, and performing multiple extractions until the extraction is complete;

[0050] S2, extracting the corresponding extracts from Paulownia flower and birch bark by water extraction, the extraction temperature is 100 degrees Celsius, the time is 1 hour, and multiple extractions are performed until the extraction is complete;

[0051] S3, mixing Semen Ziziphi Spinosae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Taraxaci, Herba Houttuyniae, Radix Glycyrrhizae and surfactant according to the above weight parts, extracting effective ingredients by the same extraction method, and mixing them evenly with Paulownia flower extract and birch extract;

[0052] S4, the mixed extract is concentrated, dried, and crushed into powder, and the powdered Chinese herbal antibacterial extract is stored.

[0053] Embodiment 3

[0054] As a preferred technical solution of the present invention, the traditional Chinese medicine antibacterial composition includes, by weight, 30 parts of Paulownia flower extract, 30 parts of white birch extract, 30 parts of Ziziphus jujuba seeds, 20 parts of honeysuckle, 15 parts of Forsythia suspensa, 25 parts of Scutellaria baicalensis, 15 parts of Taraxacum officinale, 15 parts of Houttuynia cordata, 5 parts of licorice and 3 parts of surfactant.

[0055] As a preferred technical solution of the present invention, the surfactant is selected from one or more combinations of cetylpyridinium chloride, sodium benzoate, sodium lauryl sulfate, potassium sorbate, sodium lauroyl sarcosinate, propylparaben, betaine, hydrogenated castor oil, methylparaben, benzalkonium bromide, and cetylpyridinium chloride.

[0056] As a preferred technical solution of the present invention, the Chinese medicinal antibacterial composition based on Paulownia flower extract and birch extract is prepared by the following process, specifically by the following steps:

[0057] S1. Extracting effective ingredients from Paulownia flowers by water extraction at a temperature of 95 degrees Celsius for 2 hours, and performing multiple extractions until the extraction is complete;

[0058] S2, extracting the corresponding extracts from Paulownia flower and birch bark by water extraction, the extraction temperature is 100 degrees Celsius, the time is 1 hour, and multiple extractions are performed until the extraction is complete;

[0059] S3, mixing Semen Ziziphi Spinosae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Taraxaci, Herba Houttuyniae, Radix Glycyrrhizae and surfactant according to the above weight parts, extracting effective ingredients by the same extraction method, and mixing them evenly with Paulownia flower extract and birch extract;

[0060] S4, the mixed extract is concentrated, dried, and crushed into powder, and the powdered Chinese herbal antibacterial extract is stored.

[0061] Components not described in detail herein are prior art.

[0062] Although the specific embodiments of the present invention are described in detail above, the present invention is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in this field without departing from the purpose of the present invention, and modifications or deformations without creative labor are still within the protection scope of the present invention.

Claims

1. A Chinese medicine antibacterial composition based on Paulownia flower extract and birch extract, characterized in that: The traditional Chinese medicine antibacterial composition comprises, by weight, 10-30 parts of paulownia flower extract, 10-30 parts of white birch extract, 10-30 parts of spiny jujube seeds, 5-20 parts of honeysuckle, 5-15 parts of forsythia, 10-25 parts of scutellaria, 5-15 parts of dandelion, 5-15 parts of houttuynia, 1-5 parts of licorice and 2-3 parts of a surfactant.

2. The Chinese medicinal antibacterial composition based on Paulownia flower extract and birch extract according to claim 1, characterized in that: The traditional Chinese medicine antibacterial composition comprises, by weight, 10 parts of Paulownia flower extract, 10 parts of white birch extract, 10 parts of Ziziphus jujuba seeds, 5 parts of honeysuckle, 5 parts of forsythia, 10 parts of scutellaria, 5 parts of dandelion, 5 parts of houttuynia, 1 part of licorice and 2 parts of surfactant.

3. The Chinese medicinal antibacterial composition based on Paulownia flower extract and birch tree extract according to claim 1, characterized in that: The traditional Chinese medicine antibacterial composition comprises, by weight, 20 parts of paulownia flower extract, 20 parts of white birch extract, 20 parts of spiny jujube seeds, 15 parts of honeysuckle, 10 parts of forsythia, 15 parts of scutellaria, 10 parts of dandelion, 10 parts of houttuynia, 3 parts of licorice and 2.5 parts of surfactant.

4. The Chinese medicinal antibacterial composition based on Paulownia flower extract and birch tree extract according to claim 1, characterized in that: The traditional Chinese medicine antibacterial composition comprises, by weight, 30 parts of paulownia flower extract, 30 parts of white birch extract, 30 parts of spiny jujube seeds, 20 parts of honeysuckle, 15 parts of forsythia, 25 parts of scutellaria, 15 parts of dandelion, 15 parts of houttuynia, 5 parts of licorice and 3 parts of surfactant.

5. The Chinese medicinal antibacterial composition based on Paulownia flower extract and birch tree extract according to any one of claims 1 to 4, characterized in that: The surfactant is selected from one or more combinations of cetylpyridinium chloride, sodium benzoate, sodium lauryl sulfate, potassium sorbate, sodium lauroyl sarcosinate, propylparaben, betaine, hydrogenated castor oil, methylparaben, benzalkonium bromide, and cetylpyridinium chloride.

6. The method for preparing the antibacterial composition of traditional Chinese medicine based on Paulownia flower extract and birch extract according to any one of claims 1 to 5, characterized in that: S1. Extracting effective ingredients from Paulownia flowers by water extraction at a temperature of 95 degrees Celsius for 2 hours, and performing multiple extractions until the extraction is complete; S2, extracting the corresponding extracts from Paulownia flower and birch bark by water extraction, the extraction temperature is 100 degrees Celsius, the time is 1 hour, and multiple extractions are performed until the extraction is complete; S3, mixing Semen Ziziphi Spinosae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Taraxaci, Herba Houttuyniae, Radix Glycyrrhizae and surfactant according to the above weight parts, extracting effective ingredients by the same extraction method, and mixing them evenly with Paulownia flower extract and birch extract; S4, the mixed extract is concentrated, dried, and crushed into powder, and the powdered Chinese herbal antibacterial extract is stored.